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Aliases for STRN Gene

Aliases for STRN Gene

  • Striatin, Calmodulin Binding Protein 2 3
  • Striatin, Calmodulin-Binding Protein 2 3
  • Striatin 3
  • SG2NA 3

External Ids for STRN Gene

Previous GeneCards Identifiers for STRN Gene

  • GC02M037041
  • GC02M037222
  • GC02M037050
  • GC02M036987
  • GC02M036924

Summaries for STRN Gene

GeneCards Summary for STRN Gene

STRN (Striatin, Calmodulin Binding Protein) is a Protein Coding gene. Among its related pathways are Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling and Plasma membrane estrogen receptor signaling. GO annotations related to this gene include calmodulin binding and estrogen receptor binding. An important paralog of this gene is STRN4.

UniProtKB/Swiss-Prot for STRN Gene

  • Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling

Gene Wiki entry for STRN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRN Gene

Genomics for STRN Gene

Regulatory Elements for STRN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STRN Gene

Start:
36,837,698 bp from pter
End:
36,966,530 bp from pter
Size:
128,833 bases
Orientation:
Minus strand

Genomic View for STRN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRN Gene

Proteins for STRN Gene

  • Protein details for STRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43815-STRN_HUMAN
    Recommended name:
    Striatin
    Protein Accession:
    O43815
    Secondary Accessions:
    • Q3KP65
    • Q53TQ8
    • Q9NP38

    Protein attributes for STRN Gene

    Size:
    780 amino acids
    Molecular mass:
    86132 Da
    Quaternary structure:
    • Interacts with protein phosphatase 2A (PP2A) (Potential). Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity).

    Alternative splice isoforms for STRN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRN Gene

Proteomics data for STRN Gene at MOPED

Post-translational modifications for STRN Gene

  • Ubiquitination at Lys353 and Lys456
  • Modification sites at PhosphoSitePlus

Other Protein References for STRN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STRN Gene

Domains for STRN Gene

Gene Families for STRN Gene

HGNC:
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for STRN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43815

UniProtKB/Swiss-Prot:

STRN_HUMAN :
  • O43815
Family:
  • Belongs to the WD repeat striatin family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with STRN: view

Function for STRN Gene

Molecular function for STRN Gene

GENATLAS Biochemistry: striatin,calmodulin-binding protein belonging to the WD40 repeats family,expressed in neurons,striatum,motor and olfactory system
UniProtKB/Swiss-Prot Function: Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling

Gene Ontology (GO) - Molecular Function for STRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17540176
GO:0005516 calmodulin binding NAS 10748158
GO:0030331 estrogen receptor binding IPI 15569929
GO:0032403 protein complex binding IDA 18782753
GO:0051721 protein phosphatase 2A binding IDA 18782753
genes like me logo Genes that share ontologies with STRN: view

Phenotypes for STRN Gene

GenomeRNAi human phenotypes for STRN:
genes like me logo Genes that share phenotypes with STRN: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STRN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for STRN Gene

Localization for STRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRN Gene

Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, dendritic spine. Note=CTTNBP2-binding may regulate dendritic spine distribution. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STRN Gene COMPARTMENTS Subcellular localization image for STRN gene
Compartment Confidence
cytoskeleton 4
cytosol 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for STRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 colocalizes_with protein phosphatase type 2A complex IDA 18782753
GO:0005737 cytoplasm IEA --
GO:0005923 bicellular tight junction IDA 18502210
GO:0014069 postsynaptic density ISS --
GO:0016020 membrane ISS --
genes like me logo Genes that share ontologies with STRN: view

Pathways for STRN Gene

genes like me logo Genes that share pathways with STRN: view

Pathways by source for STRN Gene

1 BioSystems pathway for STRN Gene

Gene Ontology (GO) - Biological Process for STRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007626 locomotory behavior ISS --
GO:0008285 negative regulation of cell proliferation IMP 18502210
GO:0016055 Wnt signaling pathway IMP 18502210
GO:0016358 dendrite development ISS --
GO:0070830 bicellular tight junction assembly NAS 18502210
genes like me logo Genes that share ontologies with STRN: view

Transcripts for STRN Gene

Unigene Clusters for STRN Gene

Striatin, calmodulin binding protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STRN

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for STRN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRN Gene

No ASD Table

Relevant External Links for STRN Gene

GeneLoc Exon Structure for
STRN
ECgene alternative splicing isoforms for
STRN

Expression for STRN Gene

mRNA expression in normal human tissues for STRN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STRN Gene

SOURCE GeneReport for Unigene cluster for STRN Gene Hs.127486

mRNA Expression by UniProt/SwissProt for STRN Gene

O43815-STRN_HUMAN
Tissue specificity: Preferentially expressed in brain.
genes like me logo Genes that share expressions with STRN: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for STRN Gene

Orthologs for STRN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRN 35
  • 99.74 (n)
  • 99.87 (a)
STRN 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STRN 35
  • 94.06 (n)
  • 97.44 (a)
STRN 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STRN 35
  • 95.07 (n)
  • 97.93 (a)
STRN 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Strn 35
  • 89.83 (n)
  • 96.79 (a)
Strn 16
Strn 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STRN 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRN 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Strn 35
  • 89.53 (n)
  • 96.67 (a)
chicken
(Gallus gallus)
Aves STRN 35
  • 82.4 (n)
  • 86.22 (a)
STRN 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRN 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20192 35
strn 35
  • 76.35 (n)
  • 81.62 (a)
zebrafish
(Danio rerio)
Actinopterygii STRN 36
  • 68 (a)
OneToOne
zgc:158357 35
  • 69.84 (n)
  • 75.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cka 36
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cash-1 36
  • 43 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COP1 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10811 36
  • 51 (a)
OneToOne
Species with no ortholog for STRN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRN Gene

ENSEMBL:
Gene Tree for STRN (if available)
TreeFam:
Gene Tree for STRN (if available)

Paralogs for STRN Gene

Paralogs for STRN Gene

Selected SIMAP similar genes for STRN Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STRN: view

Variants for STRN Gene

Sequence variations from dbSNP and Humsavar for STRN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1504 -- 36,838,875(+) GTACA(G/T)GATCC utr-variant-3-prime
rs711244 -- 36,841,285(-) CAGAA(A/G)GAATC utr-variant-3-prime
rs723673 -- 36,850,033(-) CATAT(C/T)GTGGC intron-variant
rs723674 -- 36,849,872(-) CAGCA(G/T)GACAT intron-variant
rs763678 -- 36,849,894(-) AGAGA(C/G)GGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STRN Gene

Variant ID Type Subtype PubMed ID
nsv428395 CNV Gain 18775914
nsv456363 CNV Gain 19166990
nsv828931 CNV Gain 20364138
nsv828942 CNV Loss 20364138
esv2719925 CNV Deletion 23290073

Relevant External Links for STRN Gene

HapMap Linkage Disequilibrium report
STRN
Human Gene Mutation Database (HGMD)
STRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRN Gene

Disorders for STRN Gene

(1) University of Copenhagen DISEASES for STRN Gene

Relevant External Links for STRN

Genetic Association Database (GAD)
STRN
Human Genome Epidemiology (HuGE) Navigator
STRN
genes like me logo Genes that share disorders with STRN: view

No data available for UniProtKB/Swiss-Prot for STRN Gene

Publications for STRN Gene

  1. Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain. (PMID: 9693043) Moqrich A. … Castets F. (Genomics 1998) 2 3 4 23
  2. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. (PMID: 10681496) Moreno C.S. … Pallas D.C. (J. Biol. Chem. 2000) 3 23
  3. Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha. (PMID: 15569929) Lu Q. … Karas R.H. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 23
  4. The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. (PMID: 18502210) Breitman M. … Rosin-Arbesfeld R. (Biochim. Biophys. Acta 2008) 3 23
  5. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M. … Gingras A.C. (Mol. Cell. Proteomics 2009) 3 23

Products for STRN Gene

Sources for STRN Gene

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