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Aliases for STRN Gene

Aliases for STRN Gene

  • Striatin 2 3 5
  • Striatin, Calmodulin-Binding Protein 2 3
  • Striatin, Calmodulin Binding Protein 3
  • SG2NA 3

External Ids for STRN Gene

Previous GeneCards Identifiers for STRN Gene

  • GC02M037041
  • GC02M037222
  • GC02M037050
  • GC02M036987
  • GC02M036924

Summaries for STRN Gene

GeneCards Summary for STRN Gene

STRN (Striatin) is a Protein Coding gene. Diseases associated with STRN include cherubism and cavernous malformation. Among its related pathways are DAG and IP3 signaling and Plasma membrane estrogen receptor signaling. GO annotations related to this gene include protein complex binding and estrogen receptor binding. An important paralog of this gene is STRN4.

UniProtKB/Swiss-Prot for STRN Gene

  • Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.

Gene Wiki entry for STRN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRN Gene

Genomics for STRN Gene

Regulatory Elements for STRN Gene

Promoters for STRN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STRN on UCSC Golden Path with GeneCards custom track

Genomic Location for STRN Gene

Chromosome:
2
Start:
36,837,698 bp from pter
End:
36,966,557 bp from pter
Size:
128,860 bases
Orientation:
Minus strand

Genomic View for STRN Gene

Genes around STRN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRN Gene

Proteins for STRN Gene

  • Protein details for STRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43815-STRN_HUMAN
    Recommended name:
    Striatin
    Protein Accession:
    O43815
    Secondary Accessions:
    • Q3KP65
    • Q53TQ8
    • Q9NP38

    Protein attributes for STRN Gene

    Size:
    780 amino acids
    Molecular mass:
    86132 Da
    Quaternary structure:
    • Interacts with protein phosphatase 2A (PP2A) (Potential). Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity).

    Alternative splice isoforms for STRN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRN Gene

Proteomics data for STRN Gene at MOPED

Post-translational modifications for STRN Gene

  • Ubiquitination at Lys 353
  • Modification sites at PhosphoSitePlus

Other Protein References for STRN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for STRN Gene

Domains & Families for STRN Gene

Suggested Antigen Peptide Sequences for STRN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43815

UniProtKB/Swiss-Prot:

STRN_HUMAN :
  • Belongs to the WD repeat striatin family.
  • Contains 6 WD repeats.
Family:
  • Belongs to the WD repeat striatin family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with STRN: view

Function for STRN Gene

Molecular function for STRN Gene

GENATLAS Biochemistry:
striatin,calmodulin-binding protein belonging to the WD40 repeats family,expressed in neurons,striatum,motor and olfactory system
UniProtKB/Swiss-Prot Function:
Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.

Gene Ontology (GO) - Molecular Function for STRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding NAS 9693043
genes like me logo Genes that share ontologies with STRN: view
genes like me logo Genes that share phenotypes with STRN: view

Animal Model Products

miRNA for STRN Gene

miRTarBase miRNAs that target STRN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STRN Gene

Localization for STRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRN Gene

Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, dendritic spine. Note=CTTNBP2-binding may regulate dendritic spine distribution. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STRN Gene COMPARTMENTS Subcellular localization image for STRN gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for STRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043025 neuronal cell body ISS --
genes like me logo Genes that share ontologies with STRN: view

Pathways & Interactions for STRN Gene

genes like me logo Genes that share pathways with STRN: view

Pathways by source for STRN Gene

1 BioSystems pathway for STRN Gene

Gene Ontology (GO) - Biological Process for STRN Gene

None

No data available for SIGNOR curated interactions for STRN Gene

Drugs & Compounds for STRN Gene

No Compound Related Data Available

Transcripts for STRN Gene

Unigene Clusters for STRN Gene

Striatin, calmodulin binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STRN Gene

No ASD Table

Relevant External Links for STRN Gene

GeneLoc Exon Structure for
STRN
ECgene alternative splicing isoforms for
STRN

Expression for STRN Gene

mRNA expression in normal human tissues for STRN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STRN Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.5) and Lymph node (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STRN Gene



SOURCE GeneReport for Unigene cluster for STRN Gene Hs.127486

mRNA Expression by UniProt/SwissProt for STRN Gene

O43815-STRN_HUMAN
Tissue specificity: Preferentially expressed in brain.
genes like me logo Genes that share expression patterns with STRN: view

Protein tissue co-expression partners for STRN Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for STRN Gene

Orthologs for STRN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STRN 35
  • 94.06 (n)
  • 97.44 (a)
STRN 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STRN 35
  • 95.07 (n)
  • 97.93 (a)
STRN 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Strn 35
  • 89.83 (n)
  • 96.79 (a)
Strn 16
Strn 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STRN 35
  • 99.74 (n)
  • 99.87 (a)
STRN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Strn 35
  • 89.53 (n)
  • 96.67 (a)
oppossum
(Monodelphis domestica)
Mammalia STRN 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRN 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves STRN 35
  • 82.4 (n)
  • 86.22 (a)
STRN 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRN 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20192 35
strn 35
  • 76.35 (n)
  • 81.62 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:158357 35
  • 69.84 (n)
  • 75.46 (a)
STRN 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cka 36
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cash-1 36
  • 43 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COP1 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10811 36
  • 51 (a)
OneToOne
Species with no ortholog for STRN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRN Gene

ENSEMBL:
Gene Tree for STRN (if available)
TreeFam:
Gene Tree for STRN (if available)

Paralogs for STRN Gene

Paralogs for STRN Gene

(2) SIMAP similar genes for STRN Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STRN: view

Variants for STRN Gene

Sequence variations from dbSNP and Humsavar for STRN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1504 -- 36,838,875(+) GTACA(G/T)GATCC utr-variant-3-prime
rs723673 -- 36,850,033(-) CATAT(C/T)GTGGC intron-variant
rs723674 -- 36,849,872(-) CAGCA(G/T)GACAT intron-variant
rs763678 -- 36,849,894(-) AGAGA(C/G)GGATG intron-variant
rs888083 -- 36,889,930(-) TGTGT(A/G)TACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STRN Gene

Variant ID Type Subtype PubMed ID
nsv428395 CNV Gain 18775914
nsv456363 CNV Gain 19166990
nsv828931 CNV Gain 20364138
nsv828942 CNV Loss 20364138
esv2719925 CNV Deletion 23290073

Variation tolerance for STRN Gene

Residual Variation Intolerance Score: 6.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STRN Gene

HapMap Linkage Disequilibrium report
STRN
Human Gene Mutation Database (HGMD)
STRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRN Gene

Disorders for STRN Gene

MalaCards: The human disease database

(2) MalaCards diseases for STRN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cherubism
  • crbm
cavernous malformation
- elite association - COSMIC cancer census association via MalaCards
Search STRN in MalaCards View complete list of genes associated with diseases

Relevant External Links for STRN

Genetic Association Database (GAD)
STRN
Human Genome Epidemiology (HuGE) Navigator
STRN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STRN
genes like me logo Genes that share disorders with STRN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STRN Gene

Publications for STRN Gene

  1. Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain. (PMID: 9693043) Moqrich A. … Castets F. (Genomics 1998) 2 3 4 23 67
  2. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M. … Gingras A.C. (Mol. Cell. Proteomics 2009) 3 23
  3. The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. (PMID: 18502210) Breitman M. … Rosin-Arbesfeld R. (Biochim. Biophys. Acta 2008) 3 23
  4. Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha. (PMID: 15569929) Lu Q. … Karas R.H. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 23
  5. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. (PMID: 10681496) Moreno C.S. … Pallas D.C. (J. Biol. Chem. 2000) 3 23

Products for STRN Gene

Sources for STRN Gene

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