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Aliases for STRN Gene

Aliases for STRN Gene

  • Striatin 2 3 3 5
  • Protein Phosphatase 2 Regulatory Subunit Balpha 2 3
  • Striatin, Calmodulin-Binding Protein 2
  • Striatin, Calmodulin Binding Protein 3
  • PPP2R6A 3
  • SG2NA 3
  • STRN1 3

External Ids for STRN Gene

Previous GeneCards Identifiers for STRN Gene

  • GC02M037041
  • GC02M037222
  • GC02M037050
  • GC02M036987
  • GC02M036924

Summaries for STRN Gene

GeneCards Summary for STRN Gene

STRN (Striatin) is a Protein Coding gene. Diseases associated with STRN include Cherubism. Among its related pathways are Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling and Plasma membrane estrogen receptor signaling. GO annotations related to this gene include protein complex binding and estrogen receptor binding. An important paralog of this gene is STRN3.

UniProtKB/Swiss-Prot for STRN Gene

  • Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.

Gene Wiki entry for STRN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRN Gene

Genomics for STRN Gene

Regulatory Elements for STRN Gene

Enhancers for STRN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F036930 1.2 Ensembl ENCODE 21.5 +35.4 35357 1.6 DNMT3B ZNF664 ZNF335 ZNF316 MLLT1 NFE2 ZBTB33 EMSY EGR2 STRN GC02P036908
GH02F037019 1 Ensembl ENCODE 20.2 -54.2 -54175 2.1 JUND JUN NR2F2 STRN GC02M036982 HEATR5B
GH02F037000 0.5 ENCODE 19.5 -34.3 -34265 1.6 SCRT1 PAF1 SCRT2 STRN GC02M036982 HEATR5B
GH02F037004 0.9 Ensembl ENCODE 18 -38.7 -38684 0.7 HDGF TBL1XR1 SIN3A ZNF2 RAD21 ETV6 CREM ZNF263 ZNF654 CBFB STRN GC02M036982 HEATR5B
GH02F036926 0.2 Ensembl 16.9 +39.8 39757 1.6 HDGF PKNOX1 ZNF146 JUNB CEBPB FEZF1 TSHZ1 ZNF843 IKZF1 TARDBP STRN CEBPZOS GC02P036908
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around STRN on UCSC Golden Path with GeneCards custom track

Promoters for STRN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000588176 357 3201 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for STRN Gene

Chromosome:
2
Start:
36,837,698 bp from pter
End:
36,966,557 bp from pter
Size:
128,860 bases
Orientation:
Minus strand

Genomic View for STRN Gene

Genes around STRN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRN Gene

Proteins for STRN Gene

  • Protein details for STRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43815-STRN_HUMAN
    Recommended name:
    Striatin
    Protein Accession:
    O43815
    Secondary Accessions:
    • Q3KP65
    • Q53TQ8
    • Q9NP38

    Protein attributes for STRN Gene

    Size:
    780 amino acids
    Molecular mass:
    86132 Da
    Quaternary structure:
    • Interacts with protein phosphatase 2A (PP2A) (Potential). Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity).

    Alternative splice isoforms for STRN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRN Gene

Post-translational modifications for STRN Gene

  • Ubiquitination at Lys 353
  • Modification sites at PhosphoSitePlus

Other Protein References for STRN Gene

No data available for DME Specific Peptides for STRN Gene

Domains & Families for STRN Gene

Suggested Antigen Peptide Sequences for STRN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43815

UniProtKB/Swiss-Prot:

STRN_HUMAN :
  • Belongs to the WD repeat striatin family.
  • Contains 6 WD repeats.
Family:
  • Belongs to the WD repeat striatin family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with STRN: view

Function for STRN Gene

Molecular function for STRN Gene

GENATLAS Biochemistry:
striatin,calmodulin-binding protein belonging to the WD40 repeats family,expressed in neurons,striatum,motor and olfactory system
UniProtKB/Swiss-Prot Function:
Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.

Gene Ontology (GO) - Molecular Function for STRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17540176
GO:0005516 calmodulin binding NAS 9693043
GO:0030331 estrogen receptor binding IPI 15569929
GO:0032403 protein complex binding IDA 18782753
GO:0051721 protein phosphatase 2A binding IDA 18782753
genes like me logo Genes that share ontologies with STRN: view
genes like me logo Genes that share phenotypes with STRN: view

Animal Models for STRN Gene

MGI Knock Outs for STRN:
  • Strn tm1a(KOMP)Wtsi

Animal Model Products

miRNA for STRN Gene

miRTarBase miRNAs that target STRN

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STRN Gene

Localization for STRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRN Gene

Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, dendritic spine. Note=CTTNBP2-binding may regulate dendritic spine distribution. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STRN Gene COMPARTMENTS Subcellular localization image for STRN gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for STRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 colocalizes_with protein phosphatase type 2A complex IDA 18782753
GO:0005737 cytoplasm IEA --
GO:0005923 bicellular tight junction IDA 18502210
GO:0014069 postsynaptic density ISS --
GO:0016020 membrane ISS --
genes like me logo Genes that share ontologies with STRN: view

Pathways & Interactions for STRN Gene

genes like me logo Genes that share pathways with STRN: view

Pathways by source for STRN Gene

1 BioSystems pathway for STRN Gene

Gene Ontology (GO) - Biological Process for STRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007626 locomotory behavior ISS --
GO:0008285 negative regulation of cell proliferation IMP 18502210
GO:0016055 Wnt signaling pathway IMP 18502210
GO:0016358 dendrite development ISS --
GO:0070830 bicellular tight junction assembly NAS 18502210
genes like me logo Genes that share ontologies with STRN: view

No data available for SIGNOR curated interactions for STRN Gene

Transcripts for STRN Gene

Unigene Clusters for STRN Gene

Striatin, calmodulin binding protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRN Gene

No ASD Table

Relevant External Links for STRN Gene

GeneLoc Exon Structure for
STRN
ECgene alternative splicing isoforms for
STRN

Expression for STRN Gene

mRNA expression in normal human tissues for STRN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STRN Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.5) and Lymph node (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STRN Gene



Protein tissue co-expression partners for STRN Gene

NURSA nuclear receptor signaling pathways regulating expression of STRN Gene:

STRN

SOURCE GeneReport for Unigene cluster for STRN Gene:

Hs.127486

mRNA Expression by UniProt/SwissProt for STRN Gene:

O43815-STRN_HUMAN
Tissue specificity: Preferentially expressed in brain.
genes like me logo Genes that share expression patterns with STRN: view

Primer Products

No data available for mRNA differential expression in normal tissues for STRN Gene

Orthologs for STRN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRN 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia STRN 34 35
  • 95.07 (n)
cow
(Bos Taurus)
Mammalia STRN 34 35
  • 94.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STRN 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Strn 34 16 35
  • 89.83 (n)
rat
(Rattus norvegicus)
Mammalia Strn 34
  • 89.53 (n)
oppossum
(Monodelphis domestica)
Mammalia STRN 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves STRN 34 35
  • 82.4 (n)
lizard
(Anolis carolinensis)
Reptilia STRN 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia strn 34
  • 76.35 (n)
Str.20192 34
zebrafish
(Danio rerio)
Actinopterygii zgc:158357 34
  • 69.84 (n)
STRN 35
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cka 35
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cash-1 35
  • 43 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COP1 35
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10811 35
  • 51 (a)
OneToOne
Species where no ortholog for STRN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRN Gene

ENSEMBL:
Gene Tree for STRN (if available)
TreeFam:
Gene Tree for STRN (if available)

Paralogs for STRN Gene

Paralogs for STRN Gene

(2) SIMAP similar genes for STRN Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for STRN Gene

genes like me logo Genes that share paralogs with STRN: view

Variants for STRN Gene

Sequence variations from dbSNP and Humsavar for STRN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1015599 -- 36,841,712(-) AAAAA(C/T)ATAAG utr-variant-3-prime
rs1015600 -- 36,841,129(-) AATAC(G/T)TAGGA utr-variant-3-prime
rs10164516 -- 36,922,516(+) cctgt(C/T)tcaaa intron-variant
rs10166161 -- 36,963,552(+) CTGCA(A/G)ACTCT intron-variant
rs10166375 -- 36,875,121(+) TTGAT(A/G)AAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STRN Gene

Variant ID Type Subtype PubMed ID
dgv3790n100 CNV gain 25217958
esv2719925 CNV deletion 23290073
nsv1144895 CNV deletion 24896259
nsv428395 CNV gain 18775914
nsv456363 CNV gain 19166990
nsv472064 CNV novel sequence insertion 20440878
nsv581470 CNV gain 21841781
nsv828931 CNV gain 20364138
nsv828942 CNV loss 20364138
nsv961027 CNV duplication 23825009
nsv963787 CNV duplication 23825009

Variation tolerance for STRN Gene

Residual Variation Intolerance Score: 6.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STRN Gene

Human Gene Mutation Database (HGMD)
STRN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRN Gene

Disorders for STRN Gene

MalaCards: The human disease database

(1) MalaCards diseases for STRN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cherubism
  • crbm
- elite association - COSMIC cancer census association via MalaCards
Search STRN in MalaCards View complete list of genes associated with diseases

Relevant External Links for STRN

Genetic Association Database (GAD)
STRN
Human Genome Epidemiology (HuGE) Navigator
STRN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STRN
genes like me logo Genes that share disorders with STRN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STRN Gene

Publications for STRN Gene

  1. Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain. (PMID: 9693043) Moqrich A. … Castets F. (Genomics 1998) 2 3 4 22 64
  2. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M. … Gingras A.C. (Mol. Cell. Proteomics 2009) 3 22 64
  3. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 46 64
  4. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 46 64
  5. The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. (PMID: 18502210) Breitman M. … Rosin-Arbesfeld R. (Biochim. Biophys. Acta 2008) 3 22 64

Products for STRN Gene

Sources for STRN Gene

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