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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STRN Gene

protein-coding   GIFtS: 60
GCID: GC02M036987

striatin, calmodulin binding protein

(Previous names: striatin, calmodulin-binding protein )
 Explore 10 diseases affiliated with
STRN via our new
 Human Malady Compendium 
Biological research products
for STRN
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Striatin, Calmodulin Binding Protein1 2
SG2NA1 2
Striatin, Calmodulin-Binding Protein1 2
Striatin1

External Ids:    HGNC: 114241   Entrez Gene: 68012   Ensembl: ENSG000001158087   OMIM: 6147655   UniProtKB: O438153   

Export aliases for STRN gene to outside databases

Previous GC identifers: GC02M037041 GC02M037222 GC02M037050 GC02M036924 GC02M036815


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: STRN_HUMAN, O43815
Function: Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in
dendritic Ca(2+) signaling

Gene Wiki entry for STRN


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STRN gene promoter:
         RFX1   Elk-1   p53   AML1a   HSF1 (long)   RORalpha1   SRY   POU2F1   POU2F1a   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTRN promoter sequence
   Search SABiosciences Chromatin IP Primers for STRN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STRN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.2   Ensembl cytogenetic band:  2p22.2   HGNC cytogenetic band: 2p22.2

STRN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STRN gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M036987:  view genomic region     (about GC identifiers)

Start:
37,070,783 bp from pter      End:
37,193,615 bp from pter
Size:
122,833 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STRN_HUMAN, O43815 (See protein sequence)
Recommended Name: Striatin  
Size: 780 amino acids; 86132 Da
Subunit: Interacts with protein phosphatase 2A (PP2A) (Potential)
Subcellular location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
Secondary accessions: Q3KP65 Q53TQ8 Q9NP38
Alternative splicing: 2 isoforms:  O43815-1   O43815-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STRN: NX_O43815

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43815

  • STRN Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003153.2  
    ENSEMBL proteins: 
     ENSP00000263918   ENSP00000368513  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: STRN
    OriGene Protein Over-expression Lysate: STRN
    OriGene Custom Protein Services for STRN 
    GenScript Custom Purified and Recombinant Proteins Services for STRN
    Novus Biologicals STRN Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for STRN

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159colocalizes with protein phosphatase type 2A complex IDA18782753
    GO:0005737cytoplasm IEA--
    GO:0005923tight junction IDA18502210
    GO:0014069postsynaptic density ISS--
    GO:0016020membrane ISS--


    STRN for ontologies           About GeneDecksing



    STRN Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of STRN
    Browse R&D Systems for Antibodies
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    Novus Biologicals STRN Antibody
    Search for Antibodies for STRN at Abcam  
    Uscn Antibodies for STRN
    ThermoFisher Antibody for STRN

    Assay Products for STRN: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STRN
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for STRN


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    STRN for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR013258 Striatin_N

    Graphical View of Domain Structure for InterPro Entry O43815

    ProtoNet protein and cluster: O43815

    1 Blocks protein family: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: STRN_HUMAN, O43815
    Similarity: Belongs to the WD repeat striatin family
    Similarity: Contains 6 WD repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: STRN_HUMAN, O43815
    Function: Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in
    dendritic Ca(2+) signaling

         Genatlas biochemistry entry for STRN:
    striatin,calmodulin-binding protein belonging to the WD40 repeats family,expressed in neurons,striatum,motor and
    olfactory system

    miRNA
    Products:
        
    miRTarBase miRNAs that target STRN:
    hsa-mir-30a (MIRT005191)

    OriGene 3'-UTR Clone: STRN
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STRN
    8/244 QIAGEN miScript miRNA Assays for microRNAs that regulate STRN (see all 244):
    hsa-miR-140-5p hsa-miR-100* hsa-miR-26a-2* hsa-miR-146a hsa-miR-3921 hsa-miR-342-3p hsa-miR-502-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidSTRN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STRN (see all 7)
    OriGene shRNA RFP: STRN
    OriGene siRNA: STRN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STRN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STRN

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STRN (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STRN
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: STRN (NM_003162)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRN 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for STRN
    Search LifeMap BioReagents cell lines for STRN

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRN

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005516calmodulin binding NAS10748158
    GO:0019904protein domain specific binding ----
    GO:0030331estrogen receptor binding IPI15569929
    GO:0032403protein complex binding IDA18782753


    STRN for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for STRN:
     Decreased viability 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling1.00
    Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling0.98
    2Plasma membrane estrogen receptor signaling
    Plasma membrane estrogen receptor signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for STRN
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling


    1 GeneGo (Thomson Reuters) Pathway for STRN
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    1 BioSystems Pathway for STRN 
        Plasma membrane estrogen receptor signaling



    STRN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STRN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/45 Interacting proteins for STRN (O438151, 3 ENSP000002639184) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1AP301531, 3, ENSP000003248044EBI-1046642,EBI-302388 I2D: score=3 STRING: ENSP00000324804
    CTTNBP2NLQ9P2B41, 3, ENSP000002712774EBI-1046642,EBI-1774273 I2D: score=2 STRING: ENSP00000271277
    STK24Q9Y6E01, 3, ENSP000003657304EBI-1046642,EBI-1054809 I2D: score=2 STRING: ENSP00000365730
    TRAF3IP3Q9Y2281, 3, ENSP000000103384EBI-1046642,EBI-765817 I2D: score=2 STRING: ENSP00000010338
    PDCD10Q9BUL81, 3EBI-1046642,EBI-2556229 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007626locomotory behavior ISS--
    GO:0008285negative regulation of cell proliferation IMP18502210
    GO:0016055Wnt receptor signaling pathway IMP18502210
    GO:0016358dendrite development ISS--
    GO:0070830tight junction assembly NAS18502210


    STRN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STRN
    Search CenterWatch for drugs/clinical trials and news about STRN 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STRN gene: 
    NM_003162.3  

    Unigene Cluster for STRN:

    Striatin, calmodulin binding protein
    Hs.127486  [show with all ESTs]
    Unigene Representative Sequence: NM_003162
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263918(uc002rpn.3 uc010ezx.3) ENST00000495595 ENST00000379213


    miRNA
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    OriGene 3'-UTR Clone: STRN
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STRN
    8/244 QIAGEN miScript miRNA Assays for microRNAs that regulate STRN (see all 244):
    hsa-miR-140-5p hsa-miR-100* hsa-miR-26a-2* hsa-miR-146a hsa-miR-3921 hsa-miR-342-3p hsa-miR-502-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidSTRN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STRN (see all 7)
    OriGene shRNA RFP: STRN
    OriGene siRNA: STRN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STRN
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STRN (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STRN
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: STRN (NM_003162)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRN 
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STRN
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STRN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STRN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STRN

    Additional cDNA sequence: 

    AF085351.1 AJ223814.1 AK026934.1 AK307836.1 BC015406.1 BC106878.2 BC106879.2 

    13 DOTS entries:

    DT.212806  DT.409113  DT.113369  DT.40127446  DT.97808073  DT.113368  DT.91641443  DT.108356 
    DT.206063  DT.121016209  DT.102826548  DT.120931990  DT.75123805 

    24/57 AceView cDNA sequences (see all 57):

    AA283050 AI539832 BP349169 AW450184 AL135549 NM_003162 CA942062 CA445013 
    BP345434 AI828854 AI954529 BC015406 BX380993 AI087874 AK026934 BX327915 
    BQ082421 BM468045 AI217332 BF112161 CA946832 AW573206 BX327916 BE882384 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STRN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTCAGATGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See STRN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STRN

    SOURCE GeneReport for Unigene cluster: Hs.127486

    UniProtKB/Swiss-Prot: STRN_HUMAN, O43815
    Tissue specificity: Preferentially expressed in brain

        SABiosciences Custom PCR Arrays for STRN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for STRN gene from 6/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves STRN1 striatin, calmodulin binding protein 82.71(n)
    86.58(a)
      421470  XM_419519.3  XP_419519.3 
    lizard
    (Anolis carolinensis)
    Reptilia STRN6
    --
    84(a)
    1 ↔ 1
    1(232677672-232733975)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ730740.12   -- 77.91(n)    BQ730740.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1583571 zgc:158357 69.7(n)
    75.13(a)
      791160  NM_001080642.1  NP_001074111.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cka6
    Connector of kinase to AP-1
    45(a)
    1 → many
    2L(8030721-8040826)
    worm
    (Caenorhabditis elegans)
    Secernentea cash-16
    CKA And Striatin Homolog family member (cash-1)
    39(a)
    1 → many
    V(10362238-10365354)


    ENSEMBL Gene Tree for STRN (if available)
    TreeFam Gene Tree for STRN (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STRN gene
    STRN32  STRN42  
    2 SIMAP similar genes for STRN using alignment to 2 protein entries:     STRN_HUMAN (see all proteins):
    STRN3    STRN4

    STRN for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for STRN
    PGOHUM00000249952 PGOHUM00000240171 PGOHUM00000240172 PGOHUM00000251364 PGOHUM00000249996


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2574 NCBI SNPs in STRN are shown (see all 2574    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1385909791,2
    C,--37064350(+) TTCGG-/GTTT  
            
    GTTTT
    1 -- ds50010--------
    rs1841659941,2
    --37064354(+) GGTTTG/TTTTTT 1 -- ds50010--------
    rs603580581,2
    F,--37064359(+) GTTTTT/CTTTGG 1 -- ds50011Minor allele frequency- C:0.06WA 118
    rs1883157601,2
    --37064410(+) CGATCC/TGGACT 1 -- ds50010--------
    rs1906653231,2
    --37064419(+) CTCCAC/GCTGCT 1 -- ds50010--------
    rs1164548711,2
    C,--37064501(+) AAATTC/GTATGT 1 -- ds50010--------
    rs1459167411,2
    --37064574(+) CTGCCA/TCAGCC 1 -- ds50010--------
    rs1868438411,2
    --37064604(+) CAGGCA/GTGAGC 1 -- ds50010--------
    rs1917292001,2
    --37064776(+) GAACAA/TGGGCA 1 -- ds50010--------
    rs1841782631,2
    --37064831(+) TGCAAA/TTCACT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for STRN (37070783 - 37193615 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for STRN
         4 CNVs: 89584 78502 89585 89586
    Human Gene Mutation Database (HGMD): STRN

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STRN
    DNA2.0 Custom Variant and Variant Library Synthesis for STRN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    STRN for disorders           About GeneDecksing

    OMIM gene information: 614765    OMIM disorders: --

    10 diseases for STRN:    About MalaCards
    cerebral cavernous malformations    cavernous malformation    cerebral cavernous malformations 3    striatonigral degeneration
    olivopontocerebellar atrophy    multiple system atrophy    cherubism    cerebritis
    schizophrenia    neuronitis

    1 disease from the University of Copenhagen DISEASES database for STRN:
    Multiple system atrophy
    Human Genome Epidemiology (HuGE) Navigator: STRN (2 documents)

    Export disorders for STRN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STRN gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with STRN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain. (PubMed id 9693043)1, 2, 3, 9 Moqrich A.... Castets F. (1998)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons. (PubMed id 8769426)1, 3 Castets F....Monneron A. (1996)
    5. The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. (PubMed id 18502210)1, 9 Breitman M....Rosin-Arbesfeld R. (2008)
    6. Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha. (PubMed id 15569929)1, 9 Lu Q....Karas R.H. (2004)
    7. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. (PubMed id 10681496)1, 9 Moreno C.S....Pallas D.C. (2000)
    8. A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein. (PubMed id 18782753)1, 9 Goudreault M....Gingras A.C. (2009)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6801 HGNC: 11424 AceView: STRN Ensembl:ENSG00000115808 euGenes: HUgn6801
    ECgene: STRN H-InvDB: STRN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STRN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STRN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STRN gene:
    Search GeneIP for patents involving STRN

    GeneCards and IP:
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     Regulatory tfbs in STRN promoter
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