Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STRN Gene

protein-coding   GIFtS: 63
GCID: GC02M036987

Striatin, Calmodulin Binding Protein

(Previous names: striatin, calmodulin-binding protein)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Striatin, Calmodulin Binding Protein1 2
Striatin, Calmodulin-Binding Protein1 2
SG2NA2
striatin2

External Ids:    HGNC: 114241   Entrez Gene: 68012   Ensembl: ENSG000001158087   OMIM: 6147655   UniProtKB: O438153   

Export aliases for STRN gene to outside databases

Previous GC identifers: GC02M037041 GC02M037222 GC02M037050 GC02M036924 GC02M036815


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for STRN Gene: 
STRN (striatin, calmodulin binding protein) is a protein-coding gene. Diseases associated with STRN include cherubism, and striatonigral degeneration, and among its related super-pathways are Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling. GO annotations related to this gene include calmodulin binding and estrogen receptor binding. An important paralog of this gene is STRN3.

UniProtKB/Swiss-Prot: STRN_HUMAN, O43815
Function: Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in
dendritic Ca(2+) signaling

Gene Wiki entry for STRN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STRN gene promoter:
         RFX1   Elk-1   p53   AML1a   HSF1 (long)   RORalpha1   SRY   POU2F1   POU2F1a   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTRN promoter sequence
   Search SABiosciences Chromatin IP Primers for STRN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STRN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.2   Ensembl cytogenetic band:  2p22.2   HGNC cytogenetic band: 2p22.2

STRN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STRN gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M036987:  view genomic region     (about GC identifiers)

Start:
37,064,841 bp from pter      End:
37,193,615 bp from pter
Size:
128,775 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STRN_HUMAN, O43815 (See protein sequence)
Recommended Name: Striatin  
Size: 780 amino acids; 86132 Da
Subunit: Interacts with protein phosphatase 2A (PP2A) (Potential). Interacts with CTTNBP2; this interaction may
regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with
CTTNBP2 (By similarity)
Subcellular location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Cell
projection, dendritic spine (By similarity). Note=CTTNBP2-binding may regulate dendritic spine distribution (By
similarity)
Secondary accessions: Q3KP65 Q53TQ8 Q9NP38
Alternative splicing: 2 isoforms:  O43815-1   O43815-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STRN: NX_O43815

Explore proteomics data for STRN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43815

  • STRN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STRN Protein Expression
    REFSEQ proteins: NP_003153.2  
    ENSEMBL proteins: 
     ENSP00000263918   ENSP00000368513  

    Human Recombinant Protein Products for STRN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for STRN
    OriGene Protein Over-expression Lysate for STRN
    OriGene MassSpec for STRN 
    OriGene Custom Protein Services for STRN
    GenScript Custom Purified and Recombinant Proteins Services for STRN
    Novus Biologicals STRN Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STRN 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159colocalizes with protein phosphatase type 2A complex IDA18782753
    GO:0005737cytoplasm IEA--
    GO:0005923tight junction IDA18502210
    GO:0014069postsynaptic density ISS--
    GO:0016020membrane ISS--

    STRN for ontologies           About GeneDecksing



    STRN Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of STRN
    Browse R&D Systems for Antibodies
    OriGene Antibodies for STRN
    OriGene Custom Antibody Services for STRN
    GenScript Custom Superior Antibodies Services for STRN
    Novus Biologicals STRN Antibody
    Abcam antibodies for STRN
    Cloud-Clone Corp. Antibodies for STRN 
    ThermoFisher Antibodies for STRN
    LSBio Antibodies in human, mouse, rat for STRN 

    Assay Products for STRN: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STRN
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STRN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STRN 
    Cloud-Clone Corp. CLIAs for STRN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR013258 Striatin_N

    Graphical View of Domain Structure for InterPro Entry O43815

    ProtoNet protein and cluster: O43815

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: STRN_HUMAN, O43815
    Similarity: Belongs to the WD repeat striatin family
    Similarity: Contains 6 WD repeats


    STRN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STRN_HUMAN, O43815
    Function: Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in
    dendritic Ca(2+) signaling

         Genatlas biochemistry entry for STRN:
    striatin,calmodulin-binding protein belonging to the WD40 repeats family,expressed in neurons,striatum,motor and
    olfactory system

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17540176
    GO:0005516calmodulin binding NAS10748158
    GO:0030331estrogen receptor binding IPI15569929
    GO:0032403protein complex binding IDA18782753
    GO:0051721protein phosphatase 2A binding IDA18782753
         
    STRN for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for STRN:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for STRN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STRN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STRN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STRN 

    miRNA
    Products:
        
    miRTarBase miRNAs that target STRN:
    hsa-mir-30a (MIRT005191)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STRN
    8/244 QIAGEN miScript miRNA Assays for microRNAs that regulate STRN (see all 244):
    hsa-miR-140-5p hsa-miR-100* hsa-miR-26a-2* hsa-miR-146a hsa-miR-3921 hsa-miR-342-3p hsa-miR-502-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidSTRN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STRN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STRN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STRN
    Sirion Biotech Customized adenovirus for overexpression of STRN

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for STRN (see all 7)
    OriGene ORF clones in mouse, rat for STRN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STRN (NM_003162)
    Sino Biological Human cDNA Clone for STRN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRN
    Sirion Biotech Customized lentivirus for stable overexpression of STRN 
                         Customized lentivirus expression plasmids for stable overexpression of STRN 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STRN
    Search LifeMap BioReagents cell lines for STRN
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STRN About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling0.98
    2Plasma membrane estrogen receptor signaling
    Plasma membrane estrogen receptor signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for STRN
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling


    1 GeneGo (Thomson Reuters) Pathway for STRN
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    1 BioSystems Pathway for STRN
        Plasma membrane estrogen receptor signaling




    STRN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STRN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/45 Interacting proteins for STRN (O438151, 3 ENSP000002639184) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1AP301531, 3, ENSP000003248044EBI-1046642,EBI-302388 I2D: score=3 STRING: ENSP00000324804
    CTTNBP2NLQ9P2B41, 3, ENSP000002712774EBI-1046642,EBI-1774273 I2D: score=2 STRING: ENSP00000271277
    STK24Q9Y6E01, 3, ENSP000003657304EBI-1046642,EBI-740175 I2D: score=2 STRING: ENSP00000365730
    TRAF3IP3Q9Y2281, 3, ENSP000000103384EBI-1046642,EBI-765817 I2D: score=2 STRING: ENSP00000010338
    PDCD10Q9BUL81, 3EBI-1046642,EBI-740195 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007626locomotory behavior ISS--
    GO:0008285negative regulation of cell proliferation IMP18502210
    GO:0016055Wnt receptor signaling pathway IMP18502210
    GO:0016358dendrite development ISS--
    GO:0070830tight junction assembly NAS18502210

    STRN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STRN

    Search CenterWatch for drugs/clinical trials and news about STRN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STRN gene: 
    NM_003162.3  

    Unigene Cluster for STRN:

    Striatin, calmodulin binding protein
    Hs.127486  [show with all ESTs]
    Unigene Representative Sequence: NM_003162
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263918(uc002rpn.3 uc010ezx.3) ENST00000495595 ENST00000379213

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STRN
    8/244 QIAGEN miScript miRNA Assays for microRNAs that regulate STRN (see all 244):
    hsa-miR-140-5p hsa-miR-100* hsa-miR-26a-2* hsa-miR-146a hsa-miR-3921 hsa-miR-342-3p hsa-miR-502-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidSTRN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STRN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STRN
    Clone
    Products:
         
    OriGene clones in human, mouse for STRN (see all 7)
    OriGene ORF clones in mouse, rat for STRN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STRN (NM_003162)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRN
    Sirion Biotech Customized lentivirus for stable overexpression of STRN 
                         Customized lentivirus expression plasmids for stable overexpression of STRN 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for STRN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STRN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STRN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STRN

    Additional mRNA sequence: 

    AF085351.1 AJ223814.1 AK026934.1 AK307836.1 BC015406.1 BC106878.2 BC106879.2 

    13 DOTS entries:

    DT.212806  DT.409113  DT.113369  DT.40127446  DT.97808073  DT.113368  DT.91641443  DT.108356 
    DT.206063  DT.121016209  DT.102826548  DT.120931990  DT.75123805 

    24/57 AceView cDNA sequences (see all 57):

    BX380993 BP349169 AW450184 NM_003162 BP345434 CA942062 AK026934 AI828854 
    CA445013 AI087874 AI539832 AL135549 BC015406 AI954529 AA283050 BC036416 
    BM561196 BQ082421 BE877605 AW573206 BE882384 BX282409 AJ223814 AW004608 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STRN expression in normal human tissues (normalized intensities)      STRN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCAGATGA
    STRN Expression
    About this image


    STRN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
             Olfactory Bulb   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Ventral Horn   
     
     Hair
             hair follicle bulge   
     
     Breast (Uncategorized)
             breast epithelium   
     
     Blood (Hematopoietic System)
             cd3+ t cells   

    See STRN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STRN

    SOURCE GeneReport for Unigene cluster: Hs.127486

    UniProtKB/Swiss-Prot: STRN_HUMAN, O43815
    Tissue specificity: Preferentially expressed in brain

        SABiosciences Custom PCR Arrays for STRN
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for STRN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STRN
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STRN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STRN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for STRN gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Strn1 , 5 striatin, calmodulin binding protein1, 5 89.83(n)1
    96.79(a)1
      17 (49.54 cM)5
    2689801  NM_011500.21  NP_035630.21 
     786499135 
    chicken
    (Gallus gallus)
    Aves STRN1 striatin, calmodulin binding protein 82.71(n)
    86.58(a)
      421470  XM_419519.3  XP_419519.3 
    lizard
    (Anolis carolinensis)
    Reptilia STRN6
    Uncharacterized protein
    78(a)
    1 ↔ 1
    1(232677672-232733975)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ730740.12   -- 77.91(n)    BQ730740.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1583571 zgc:158357 69.7(n)
    75.13(a)
      791160  NM_001080642.1  NP_001074111.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cka6
    Connector of kinase to AP-1
    46(a)
    1 → many
    2L(8030721-8040826)
    worm
    (Caenorhabditis elegans)
    Secernentea cash-16
    Protein CASH-1
    41(a)
    1 → many
    V(10362261-10365377)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP466
    Member of the NineTeen Complex (NTC) that contains...
    14(a)
    1 → many
    XVI(266180-267535)


    ENSEMBL Gene Tree for STRN (if available)
    TreeFam Gene Tree for STRN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STRN gene
    STRN32  STRN42  
    2 SIMAP similar genes for STRN using alignment to 2 protein entries:     STRN_HUMAN (see all proteins):
    STRN3    STRN4

    STRN for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for STRN
    PGOHUM00000249952 PGOHUM00000240171 PGOHUM00000240172 PGOHUM00000251364 PGOHUM00000249996


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3024 SNPs in STRN are shown (see all 3024)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs599993701,2
    C--36960150(+) CACAC-/ACACAC
            
    TTCTC
    1 -- int11Minor allele frequency- ACACAC:0.00NA 2
    rs1385909791,2
    C--37064350(+) TTCGG-/GTTT  
            
    GTTTT
    1 -- ds50010--------
    rs1841659941,2
    --37064354(+) GGTTTG/TTTTTT 1 -- ds50010--------
    rs603580581,2
    F--37064359(+) GTTTTT/CTTTGG 1 -- ds50011Minor allele frequency- C:0.06WA 118
    rs1883157601,2
    --37064410(+) CGATCC/TGGACT 1 -- ds50010--------
    rs1906653231,2
    --37064419(+) CTCCAC/GCTGCT 1 -- ds50010--------
    rs1164548711,2
    C,F--37064501(+) AAATTC/GTATGT 1 -- ds50010--------
    rs1459167411,2
    C--37064574(+) CTGCCA/TCAGCC 1 -- ds50010--------
    rs1868438411,2
    --37064604(+) CAGGCA/GTGAGC 1 -- ds50010--------
    rs1917292001,2
    --37064776(+) GAACAA/TGGGCA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for STRN (37064841 - 37193615 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for STRN:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2719925CNV Deletion23290073
    nsv828942CNV Loss20364138
    nsv456363CNV Gain19166990
    nsv828931CNV Gain20364138
    nsv428395CNV Gain18775914


    Human Gene Mutation Database (HGMD): STRN
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing STRN
    DNA2.0 Custom Variant and Variant Library Synthesis for STRN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614765    OMIM disorders: --

    12 diseases for STRN:    About MalaCards
    cherubism    striatonigral degeneration    olivopontocerebellar atrophy    cerebral cavernous malformations 3
    cavernous malformation    cerebral cavernous malformation    multiple system atrophy    cerebritis
    myocardial infarction    schizophrenia    endotheliitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for STRN:
    Multiple system atrophy

    STRN for disorders           About GeneDecksing

    Genetic Association Database (GAD): STRN
    Human Genome Epidemiology (HuGE) Navigator: STRN (2 documents)

    Export disorders for STRN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STRN gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with STRN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain. (PubMed id 9693043)1, 2, 3, 9 Moqrich A.... Castets F. (1998)
    2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. (2009)
    3. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (2008)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons. (PubMed id 8769426)1, 3 Castets F....Monneron A. (1996)
    7. The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. (PubMed id 18502210)1, 9 Breitman M....Rosin-Arbesfeld R. (2008)
    8. Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha. (PubMed id 15569929)1, 9 Lu Q....Karas R.H. (2004)
    9. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. (PubMed id 10681496)1, 9 Moreno C.S....Pallas D.C. (2000)
    10. A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein. (PubMed id 18782753)1, 9 Goudreault M....Gingras A.C. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6801 HGNC: 11424 AceView: STRN Ensembl:ENSG00000115808 euGenes: HUgn6801
    ECgene: STRN H-InvDB: STRN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STRN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STRN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STRN gene:
    Search GeneIP for patents involving STRN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of STRN
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for STRN   OriGene RNAi products in human, mouse, rat for STRN  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for STRN  
     OriGene MassSpec something-or-other for STRN   OriGene clones in human, mouse for STRN  
     OriGene qSTAR qPCR primer pairs in human, mouse for STRN   OriGene Purified Protein for STRN  
     OriGene ORF clones in mouse, rat for STRN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for STRN   OriGene Custom Protein Services for STRN  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STRN
     QIAGEN SeqTarget long-range PCR primers for resequencing STRN
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STRN
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STRN
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STRN
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STRN
     GenScript Custom Purified and Recombinant Proteins Services for STRN GenScript cDNA clones with any tag delivered in your preferred vector for STRN
     GenScript Custom Assay Services for STRN GenScript Custom Superior Antibodies Services for STRN
     GenScript Custom overexpressing Cell Line Services for STRN CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in STRN promoter
     Search Chromatin IP Primers for STRN
     RT2 qPCR Primer Assay in human, mouse, rat STRN
     GNC Network for STRN
     SABiosciences Custom PCR Arrays for STRN
     Search Tocris compounds for STRN
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for STRN
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     STRN antibodies
     STRN lysates
     Antibodies for STRN
     See all of Abcam's Antibodies, Kits and Proteins for STRN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for STRN
     Antibodies for STRN
     ELISAs for STRN
     CLIAs for STRN
     Search LifeMap BioReagents cell lines for STRN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRN
     SwitchGear 3'UTR luciferase reporter plasmids for STRN
     SwitchGear Promoter luciferase reporter plasmids for STRN
     ThermoFisher Antibodies for STRN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRN
     inGenious Targeting Laboratory - Custom generated mouse model solutions for STRN
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STRN
    Customized:
     lentivirus for stable overexpression of STRN
     lentivirus expression plasmids for stable overexpression of STRN
     adenovirus for overexpression of STRN
     LSBio Antibodies in human, mouse, rat for STRN
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      STRN gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4