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STRN Gene

protein-coding   GIFtS: 63
GCID: GC02M036987

Striatin, Calmodulin Binding Protein

(Previous names: striatin, calmodulin-binding protein)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Striatin, Calmodulin Binding Protein1 2
Striatin, Calmodulin-Binding Protein1 2
SG2NA2
striatin2

External Ids:    HGNC: 114241   Entrez Gene: 68012   Ensembl: ENSG000001158087   OMIM: 6147655   UniProtKB: O438153   

Export aliases for STRN gene to outside databases

Previous GC identifers: GC02M037041 GC02M037222 GC02M037050 GC02M036924 GC02M036815


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STRN Gene:
STRN (striatin, calmodulin binding protein) is a protein-coding gene. GO annotations related to this gene include calmodulin binding and estrogen receptor binding. An important paralog of this gene is STRN3.

UniProtKB/Swiss-Prot: STRN_HUMAN, O43815
Function: Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in
dendritic Ca(2+) signaling

Gene Wiki entry for STRN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STRN gene promoter:
         RFX1   Elk-1   p53   AML1a   HSF1 (long)   RORalpha1   SRY   POU2F1   POU2F1a   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTRN promoter sequence
   Search Chromatin IP Primers for STRN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STRN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.2   Ensembl cytogenetic band:  2p22.2   HGNC cytogenetic band: 2p22.2

STRN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STRN gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M036987:  view genomic region     (about GC identifiers)

Start:
37,064,841 bp from pter      End:
37,193,615 bp from pter
Size:
128,775 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: STRN_HUMAN, O43815 (See protein sequence)
Recommended Name: Striatin  
Size: 780 amino acids; 86132 Da
Subunit: Interacts with protein phosphatase 2A (PP2A) (Potential). Interacts with CTTNBP2; this interaction may
regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with
CTTNBP2 (By similarity)
Secondary accessions: Q3KP65 Q53TQ8 Q9NP38
Alternative splicing: 2 isoforms:  O43815-1   O43815-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STRN: NX_O43815

Explore proteomics data for STRN at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys353, Lys456
  • Modification sites at PhosphoSitePlus

  • See STRN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003153.2  
    ENSEMBL proteins: 
     ENSP00000263918   ENSP00000368513  

    STRN Human Recombinant Protein Products:

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    OriGene Purified Protein for STRN
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    Novus Biologicals STRN Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STRN

     
    Search eBioscience for Proteins for STRN 

     
    antibodies-online proteins for STRN (2 products) 

     
    antibodies-online peptides for STRN

    STRN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of STRN
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    Abcam antibodies for STRN
    Cloud-Clone Corp. Antibodies for STRN
    ThermoFisher Antibodies for STRN
    antibodies-online antibodies for STRN (19 products) 

    STRN Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for STRN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STRN
    Cloud-Clone Corp. CLIAs for STRN
    Search eBioscience for ELISAs for STRN 
    antibodies-online kits for STRN (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR013258 Striatin_N

    Graphical View of Domain Structure for InterPro Entry O43815

    ProtoNet protein and cluster: O43815

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: STRN_HUMAN, O43815
    Similarity: Belongs to the WD repeat striatin family
    Similarity: Contains 6 WD repeats


    Find genes that share domains with STRN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STRN_HUMAN, O43815
    Function: Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in
    dendritic Ca(2+) signaling

         Genatlas biochemistry entry for STRN:
    striatin,calmodulin-binding protein belonging to the WD40 repeats family,expressed in neurons,striatum,motor and
    olfactory system

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17540176
    GO:0005516calmodulin binding NAS10748158
    GO:0030331estrogen receptor binding IPI15569929
    GO:0032403protein complex binding IDA18782753
    GO:0051721protein phosphatase 2A binding IDA18782753
         
    Find genes that share ontologies with STRN           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STRN:
     Decreased viability 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for STRN

    miRNA
    Products:
        
    miRTarBase miRNAs that target STRN:
    hsa-mir-197-3p (MIRT048077), hsa-mir-155-5p (MIRT020667), hsa-mir-30a-5p (MIRT005191), hsa-mir-484 (MIRT041939), hsa-mir-342-3p (MIRT043722)

    Block miRNA regulation of human, mouse, rat STRN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STRN (see all 244):
    hsa-miR-140-5p hsa-miR-100* hsa-miR-26a-2* hsa-miR-146a hsa-miR-3921 hsa-miR-342-3p hsa-miR-502-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidSTRN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STRN
    Predesigned siRNA for gene silencing in human, mouse, rat STRN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STRN

    Clone
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    OriGene clones in human, mouse for STRN (see all 6)
    OriGene ORF clones in mouse, rat for STRN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STRN (NM_003162)
    Sino Biological Human cDNA Clone for STRN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRN

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for STRN
    Browse ESI BIO Cell Lines and PureStem Progenitors for STRN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STRN_HUMAN, O43815: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Cell
    projection, dendritic spine (By similarity). Note=CTTNBP2-binding may regulate dendritic spine distribution (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol2
    nucleus2
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159colocalizes with protein phosphatase type 2A complex IDA18782753
    GO:0005737cytoplasm IEA--
    GO:0005923tight junction IDA18502210
    GO:0014069postsynaptic density ISS--
    GO:0016020membrane ISS--

    Find genes that share ontologies with STRN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STRN About    
    See pathways by source

    SuperPathContained pathways About
    1Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling0.32
    2Plasma membrane estrogen receptor signaling
    Plasma membrane estrogen receptor signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for STRN
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    1 BioSystems Pathway for STRN
        Plasma membrane estrogen receptor signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STRN
    Interactions:

        GeneGlobe Interaction Network for STRN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STRN (O438151, 3 ENSP000002639184) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1AP301531, 3, ENSP000003248044EBI-1046642,EBI-302388 I2D: score=3 STRING: ENSP00000324804
    CTTNBP2NLQ9P2B41, 3, ENSP000002712774EBI-1046642,EBI-1774273 I2D: score=2 STRING: ENSP00000271277
    STK24Q9Y6E01, 3, ENSP000003657304EBI-1046642,EBI-740175 I2D: score=2 STRING: ENSP00000365730
    TRAF3IP3Q9Y2281, 3, ENSP000000103384EBI-1046642,EBI-765817 I2D: score=2 STRING: ENSP00000010338
    PDCD10Q9BUL81, 3EBI-1046642,EBI-740195 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007626locomotory behavior ISS--
    GO:0008285negative regulation of cell proliferation IMP18502210
    GO:0016055Wnt signaling pathway IMP18502210
    GO:0016358dendrite development ISS--
    GO:0070830tight junction assembly NAS18502210

    Find genes that share ontologies with STRN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STRN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STRN gene: 
    NM_003162.3  

    Unigene Cluster for STRN:

    Striatin, calmodulin binding protein
    Hs.127486  [show with all ESTs]
    Unigene Representative Sequence: NM_003162
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263918(uc002rpn.3 uc010ezx.3) ENST00000495595 ENST00000379213

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STRN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STRN (see all 244):
    hsa-miR-140-5p hsa-miR-100* hsa-miR-26a-2* hsa-miR-146a hsa-miR-3921 hsa-miR-342-3p hsa-miR-502-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidSTRN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STRN
    Predesigned siRNA for gene silencing in human, mouse, rat STRN
    Clone
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    OriGene clones in human, mouse for STRN (see all 6)
    OriGene ORF clones in mouse, rat for STRN
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    GenScript: all cDNA clones in your preferred vector: STRN (NM_003162)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRN
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for STRN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STRN
      QuantiTect SYBR Green Assays in human, mouse, rat STRN
      QuantiFast Probe-based Assays in human, mouse, rat STRN

    Additional mRNA sequence: 

    AF085351.1 AJ223814.1 AK026934.1 AK307836.1 BC015406.1 BC106878.2 BC106879.2 

    13 DOTS entries:

    DT.212806  DT.409113  DT.113369  DT.40127446  DT.97808073  DT.113368  DT.91641443  DT.108356 
    DT.206063  DT.121016209  DT.102826548  DT.120931990  DT.75123805 

    Selected AceView cDNA sequences (see all 57):

    AI828854 BC015406 BX380993 BP345434 AI539832 CA942062 NM_003162 AW450184 
    AA283050 AL135549 BP349169 CA445013 AK026934 AI087874 AI954529 BQ082421 
    BC036416 AW573206 BM468045 BX327916 CA843441 AI217332 AW004608 CA946832 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STRN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCAGATGA
    STRN Expression
    About this image


    STRN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
    STRN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STRN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.127486

    UniProtKB/Swiss-Prot: STRN_HUMAN, O43815
    Tissue specificity: Preferentially expressed in brain

        Custom PCR Arrays for STRN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for STRN gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Strn1 , 5 striatin, calmodulin binding protein1, 5 89.83(n)1
    96.79(a)1
      17 (49.54 cM)5
    2689801  NM_011500.21  NP_035630.21 
     786499135 
    chicken
    (Gallus gallus)
    Aves STRN1 striatin, calmodulin binding protein 82.4(n)
    86.22(a)
      421470  XM_004935419.1  XP_004935476.1 
    lizard
    (Anolis carolinensis)
    Reptilia STRN6
    striatin, calmodulin binding protein
    78(a)
    1 ↔ 1
    1(232677672-232733975)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ730740.12   -- 77.91(n)    BQ730740.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1583571 zgc:158357 69.84(n)
    75.46(a)
      791160  NM_001080642.1  NP_001074111.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cka6
    Connector of kinase to AP-1
    48(a)
    1 ↔ 1
    2L(8030721-8040826)
    worm
    (Caenorhabditis elegans)
    Secernentea cash-16
    Protein CASH-1 (cash-1) mRNA, complete cds
    43(a)
    1 ↔ 1
    V(10362261-10366014) WBGene00010631
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COP16
    Alpha subunit of COPI vesicle coatomer complex, wh...
    9(a)
    1 → many
    IV(194571-198176) YDL145C


    ENSEMBL Gene Tree for STRN (if available)
    TreeFam Gene Tree for STRN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STRN gene
    STRN32  COPA2  STRN42  
    2 SIMAP similar genes for STRN using alignment to 2 protein entries:     STRN_HUMAN (see all proteins):
    STRN3    STRN4

    Find genes that share paralogs with STRN           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for STRN
    PGOHUM00000249952 PGOHUM00000240171 PGOHUM00000240172 PGOHUM00000251364 PGOHUM00000249996


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STRN (see all 3024)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs599993701,2
    C--36960150(+) CACAC-/ACACAC
            
    TTCTC
    1 -- int11Minor allele frequency- ACACAC:0.00NA 2
    rs1385909791,2
    C--37064350(+) TTCGG-/GTTT  
            
    GTTTT
    1 -- ds50010--------
    rs1841659941,2
    --37064354(+) GGTTTG/TTTTTT 1 -- ds50010--------
    rs603580581,2
    F--37064359(+) GTTTTT/CTTTGG 1 -- ds50011Minor allele frequency- C:0.06WA 118
    rs1883157601,2
    --37064410(+) CGATCC/TGGACT 1 -- ds50010--------
    rs1906653231,2
    --37064419(+) CTCCAC/GCTGCT 1 -- ds50010--------
    rs1164548711,2
    C,F--37064501(+) AAATTC/GTATGT 1 -- ds50010--------
    rs1459167411,2
    C--37064574(+) CTGCCA/TCAGCC 1 -- ds50010--------
    rs1868438411,2
    --37064604(+) CAGGCA/GTGAGC 1 -- ds50010--------
    rs1917292001,2
    --37064776(+) GAACAA/TGGGCA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for STRN (37064841 - 37193615 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for STRN:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719925CNV Deletion23290073
    nsv828942CNV Loss20364138
    nsv456363CNV Gain19166990
    nsv828931CNV Gain20364138
    nsv428395CNV Gain18775914

    Human Gene Mutation Database (HGMD): STRN
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing STRN
    DNA2.0 Custom Variant and Variant Library Synthesis for STRN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614765    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for STRN:
    Multiple system atrophy

    Find genes that share disorders with STRN           About GenesLikeMe

    Genetic Association Database (GAD): STRN
    Human Genome Epidemiology (HuGE) Navigator: STRN (2 documents)

    Export disorders for STRN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STRN gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with STRN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain. (PubMed id 9693043)1, 2, 3, 9 Moqrich A.... Castets F. (Genomics 1998)
    2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    3. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons. (PubMed id 8769426)1, 3 Castets F....Monneron A. (J. Cell Biol. 1996)
    7. The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. (PubMed id 18502210)1, 9 Breitman M....Rosin-Arbesfeld R. (Biochim. Biophys. Acta 2008)
    8. Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha. (PubMed id 15569929)1, 9 Lu Q....Karas R.H. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    9. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. (PubMed id 10681496)1, 9 Moreno C.S....Pallas D.C. (J. Biol. Chem. 2000)
    10. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PubMed id 18782753)1, 9 Goudreault M.... Gingras A.C. (Mol. Cell. Proteomics 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6801 HGNC: 11424 AceView: STRN Ensembl:ENSG00000115808 euGenes: HUgn6801
    ECgene: STRN H-InvDB: STRN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STRN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STRN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STRN gene:
    Search GeneIP for patents involving STRN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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