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Aliases for STRIP2 Gene

Aliases for STRIP2 Gene

  • Striatin Interacting Protein 2 2 3 5
  • Family With Sequence Similarity 40, Member B 2 3
  • Protein FAM40B 3 4
  • FAM40B 3 4
  • FAR11 Factor Arrest 11 Homolog B (Yeast) 2
  • FAR11 Factor Arrest 11 Homolog B 3
  • Homolog Of Yeast FAR11 Protein 2 3
  • Striatin-Interacting Protein 2 3
  • KIAA1170 4
  • FAR11B 3

External Ids for STRIP2 Gene

Previous HGNC Symbols for STRIP2 Gene

  • FAM40B

Previous GeneCards Identifiers for STRIP2 Gene

  • GC07P129074

Summaries for STRIP2 Gene

GeneCards Summary for STRIP2 Gene

STRIP2 (Striatin Interacting Protein 2) is a Protein Coding gene. An important paralog of this gene is STRIP1.

UniProtKB/Swiss-Prot for STRIP2 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRIP2 Gene

Genomics for STRIP2 Gene

Regulatory Elements for STRIP2 Gene

Enhancers for STRIP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G129367 1.2 Ensembl ENCODE 10.4 -66.2 -66227 2.0 ATF1 WRNIP1 ZNF143 ZNF207 DEK JUNB REST TBX21 ZNF579 STAT3 STRIP2 LOC105375500 GC07M129358
GH07G129221 1.2 Ensembl ENCODE 8.3 -212.3 -212258 1.0 HDGF ATF1 CREB3L1 MLX DMAP1 ZNF2 ZNF143 FOS YY2 REST AHCYL2 ENSG00000273270 STRIP2 ENSG00000243230
GH07G129480 0.6 ENCODE 16.3 +46.6 46631 1.1 CBX3 CBX5 ZBED1 CEBPB CEBPG TRIM28 STRIP2 AHCYL2 ENSG00000243230 RNU7-16P ENSG00000244036 TSPAN33 GC07P129478 GC07P129486
GH07G129455 0.6 FANTOM5 16 +21.5 21548 0.4 BCOR CBFB HLF ZMYM3 ZNF121 EED ETV6 IKZF2 STRIP2 RNU7-16P AHCYL2 ENSG00000243230 SMKR1 GC07P129449 SNRPGP3
GH07G129298 0.9 ENCODE 10.2 -136.0 -136019 0.2 HDGF SIN3A RAD21 GLIS2 SCRT2 ZNF143 RELB ZNF263 ZNF654 SMAD5 AHCYL2 ENSG00000243230 STRIP2 GC07M129240 LOC105375500
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STRIP2 on UCSC Golden Path with GeneCards custom track

Promoters for STRIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000217852 167 1601 FOXA2 CREB3L1 AGO1 ARID4B SIN3A DMAP1 FOS SP3 NFYC REST

Genomic Location for STRIP2 Gene

Chromosome:
7
Start:
129,434,433 bp from pter
End:
129,488,399 bp from pter
Size:
53,967 bases
Orientation:
Plus strand

Genomic View for STRIP2 Gene

Genes around STRIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRIP2 Gene

Proteins for STRIP2 Gene

  • Protein details for STRIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULQ0-STRP2_HUMAN
    Recommended name:
    Striatin-interacting protein 2
    Protein Accession:
    Q9ULQ0
    Secondary Accessions:
    • Q8WUZ4

    Protein attributes for STRIP2 Gene

    Size:
    834 amino acids
    Molecular mass:
    95360 Da
    Quaternary structure:
    • Component of striatin-interacting phosphatase and kinase (STRIPAK) complex (By similarity). Interacts with CTTNBP2NL.
    SequenceCaution:
    • Sequence=BAA86484.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for STRIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRIP2 Gene

Post-translational modifications for STRIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STRIP2 Gene

Domains & Families for STRIP2 Gene

Gene Families for STRIP2 Gene

Protein Domains for STRIP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STRIP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULQ0

UniProtKB/Swiss-Prot:

STRP2_HUMAN :
  • Belongs to the STRIP family.
Family:
  • Belongs to the STRIP family.
genes like me logo Genes that share domains with STRIP2: view

Function for STRIP2 Gene

Molecular function for STRIP2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Gene Ontology (GO) - Molecular Function for STRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with STRIP2: view

Phenotypes for STRIP2 Gene

genes like me logo Genes that share phenotypes with STRIP2: view

Animal Model Products

CRISPR Products

miRNA for STRIP2 Gene

miRTarBase miRNAs that target STRIP2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STRIP2 Gene

Localization for STRIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRIP2 Gene

Cytoplasm. Note=Enriched in lamellipodia.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STRIP2 gene
Compartment Confidence
cytosol 5
nucleus 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for STRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 21834987
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with STRIP2: view

Pathways & Interactions for STRIP2 Gene

SuperPathways for STRIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP 21834987
GO:0008360 regulation of cell shape IMP 21834987
GO:0016477 cell migration IMP 21834987
genes like me logo Genes that share ontologies with STRIP2: view

No data available for Pathways by source and SIGNOR curated interactions for STRIP2 Gene

Drugs & Compounds for STRIP2 Gene

No Compound Related Data Available

Transcripts for STRIP2 Gene

Unigene Clusters for STRIP2 Gene

Striatin interacting protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRIP2 Gene

No ASD Table

Relevant External Links for STRIP2 Gene

GeneLoc Exon Structure for
STRIP2
ECgene alternative splicing isoforms for
STRIP2

Expression for STRIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STRIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STRIP2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.2), Brain - Caudate (basal ganglia) (x7.9), Brain - Putamen (basal ganglia) (x7.4), and Muscle - Skeletal (x6.2).

Protein differential expression in normal tissues from HIPED for STRIP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.1) and Heart (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STRIP2 Gene



Protein tissue co-expression partners for STRIP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of STRIP2 Gene:

STRIP2

SOURCE GeneReport for Unigene cluster for STRIP2 Gene:

Hs.489988

Evidence on tissue expression from TISSUES for STRIP2 Gene

  • Nervous system(4.4)
  • Kidney(4.1)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with STRIP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STRIP2 Gene

Orthologs for STRIP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRIP2 34 35
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia STRIP2 34 35
  • 93.05 (n)
cow
(Bos Taurus)
Mammalia STRIP2 34 35
  • 92.57 (n)
mouse
(Mus musculus)
Mammalia Strip2 34 16 35
  • 90.25 (n)
oppossum
(Monodelphis domestica)
Mammalia STRIP2 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC500066 34
  • 84.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STRIP2 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves STRIP2 35
  • 79 (a)
OneToOne
FAM40B 34
  • 76.57 (n)
lizard
(Anolis carolinensis)
Reptilia STRIP2 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia strip2 34
  • 69.2 (n)
Str.15326 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8705 34
zebrafish
(Danio rerio)
Actinopterygii strip2 35
  • 72 (a)
OneToOne
LOC556392 34
  • 70.39 (n)
Dr.14188 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10622 34
fruit fly
(Drosophila melanogaster)
Insecta CG11526 35
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea farl-11 34 35
  • 50.28 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAR11 35
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1783 34
Species where no ortholog for STRIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRIP2 Gene

ENSEMBL:
Gene Tree for STRIP2 (if available)
TreeFam:
Gene Tree for STRIP2 (if available)

Paralogs for STRIP2 Gene

Paralogs for STRIP2 Gene

(3) SIMAP similar genes for STRIP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STRIP2: view

Variants for STRIP2 Gene

Sequence variations from dbSNP and Humsavar for STRIP2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000001238 -- 129,440,456(+) CCTAC(A/T)TCTTT intron-variant
rs1000014712 -- 129,439,361(+) GAAAA(A/T)TTTAA intron-variant
rs1000119000 -- 129,454,689(+) ACAAG(A/G)GCTGG intron-variant
rs1000195978 -- 129,451,062(+) CTCCC(A/G/T)AGTAG intron-variant, upstream-variant-2KB
rs1000222626 -- 129,446,619(+) GAACC(A/G)TCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STRIP2 Gene

Variant ID Type Subtype PubMed ID
esv2674446 CNV deletion 23128226
esv3614998 CNV loss 21293372
nsv831128 CNV gain 17160897
nsv966886 CNV duplication 23825009

Variation tolerance for STRIP2 Gene

Residual Variation Intolerance Score: 7.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.30; 70.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STRIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STRIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRIP2 Gene

Disorders for STRIP2 Gene

Relevant External Links for STRIP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STRIP2

No disorders were found for STRIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STRIP2 Gene

Publications for STRIP2 Gene

  1. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M. … Gingras A.C. (Mol. Cell. Proteomics 2009) 2 3 4 64
  2. TORC2 signaling is antagonized by protein phosphatase 2A and the Far complex in Saccharomyces cerevisiae. (PMID: 22298706) Pracheil T. … Liu Z. (Genetics 2012) 2 3 64
  3. The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling. (PMID: 22782902) Lisa-SantamarA-a P. … Revuelta J.L. (J. Biol. Chem. 2012) 2 3 64
  4. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for STRIP2 Gene

Sources for STRIP2 Gene

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