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Aliases for STRIP2 Gene

Aliases for STRIP2 Gene

  • Striatin Interacting Protein 2 2 3 5
  • Family With Sequence Similarity 40, Member B 2 3
  • Protein FAM40B 3 4
  • FAM40B 3 4
  • FAR11 Factor Arrest 11 Homolog B (Yeast) 2
  • FAR11 Factor Arrest 11 Homolog B 3
  • Homolog Of Yeast FAR11 Protein 2 3
  • KIAA1170 4
  • FAR11B 3

External Ids for STRIP2 Gene

Previous HGNC Symbols for STRIP2 Gene

  • FAM40B

Previous GeneCards Identifiers for STRIP2 Gene

  • GC07P129074

Summaries for STRIP2 Gene

GeneCards Summary for STRIP2 Gene

STRIP2 (Striatin Interacting Protein 2) is a Protein Coding gene. An important paralog of this gene is STRIP1.

UniProtKB/Swiss-Prot for STRIP2 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRIP2 Gene

Genomics for STRIP2 Gene

Regulatory Elements for STRIP2 Gene

Promoters for STRIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STRIP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for STRIP2 Gene

Chromosome:
7
Start:
129,434,433 bp from pter
End:
129,488,399 bp from pter
Size:
53,967 bases
Orientation:
Plus strand

Genomic View for STRIP2 Gene

Genes around STRIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRIP2 Gene

Proteins for STRIP2 Gene

  • Protein details for STRIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULQ0-STRP2_HUMAN
    Recommended name:
    Striatin-interacting protein 2
    Protein Accession:
    Q9ULQ0
    Secondary Accessions:
    • Q8WUZ4

    Protein attributes for STRIP2 Gene

    Size:
    834 amino acids
    Molecular mass:
    95360 Da
    Quaternary structure:
    • Component of striatin-interacting phosphatase and kinase (STRIPAK) complex (By similarity). Interacts with CTTNBP2NL.
    SequenceCaution:
    • Sequence=BAA86484.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for STRIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRIP2 Gene

Proteomics data for STRIP2 Gene at MOPED

Post-translational modifications for STRIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STRIP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STRIP2 Gene

Domains & Families for STRIP2 Gene

Protein Domains for STRIP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STRIP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULQ0

UniProtKB/Swiss-Prot:

STRP2_HUMAN :
  • Belongs to the STRIP family.
Family:
  • Belongs to the STRIP family.
genes like me logo Genes that share domains with STRIP2: view

No data available for Gene Families for STRIP2 Gene

Function for STRIP2 Gene

Molecular function for STRIP2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Phenotypes for STRIP2 Gene

genes like me logo Genes that share phenotypes with STRIP2: view

Animal Model Products

miRNA for STRIP2 Gene

miRTarBase miRNAs that target STRIP2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STRIP2 Gene

Localization for STRIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRIP2 Gene

Cytoplasm. Note=Enriched in lamellipodia.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STRIP2 Gene COMPARTMENTS Subcellular localization image for STRIP2 gene
Compartment Confidence
cytosol 3
nucleus 2
golgi apparatus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for STRIP2 Gene

Pathways & Interactions for STRIP2 Gene

SuperPathways for STRIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008360 regulation of cell shape IMP 21834987
genes like me logo Genes that share ontologies with STRIP2: view

No data available for Pathways by source and SIGNOR curated interactions for STRIP2 Gene

Drugs & Compounds for STRIP2 Gene

No Compound Related Data Available

Transcripts for STRIP2 Gene

Unigene Clusters for STRIP2 Gene

Striatin interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STRIP2 Gene

No ASD Table

Relevant External Links for STRIP2 Gene

GeneLoc Exon Structure for
STRIP2
ECgene alternative splicing isoforms for
STRIP2

Expression for STRIP2 Gene

mRNA expression in normal human tissues for STRIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STRIP2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.2), Brain - Caudate (basal ganglia) (x7.9), Brain - Putamen (basal ganglia) (x7.4), and Muscle - Skeletal (x6.2).

Protein differential expression in normal tissues from HIPED for STRIP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.1) and Heart (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STRIP2 Gene



SOURCE GeneReport for Unigene cluster for STRIP2 Gene Hs.489988

genes like me logo Genes that share expression patterns with STRIP2: view

Protein tissue co-expression partners for STRIP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for STRIP2 Gene

Orthologs for STRIP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRIP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STRIP2 35
  • 92.57 (n)
  • 97.41 (a)
STRIP2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STRIP2 35
  • 93.05 (n)
  • 97.72 (a)
STRIP2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Strip2 35
  • 90.25 (n)
  • 95.56 (a)
Strip2 16
Strip2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STRIP2 35
  • 99.72 (n)
  • 99.88 (a)
STRIP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC500066 35
  • 84.72 (n)
  • 88.57 (a)
oppossum
(Monodelphis domestica)
Mammalia STRIP2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRIP2 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM40B 35
  • 76.57 (n)
  • 82.08 (a)
STRIP2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRIP2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15326 35
strip2 35
  • 69.2 (n)
  • 74.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8705 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14188 35
LOC556392 35
  • 70.39 (n)
  • 74.97 (a)
strip2 36
  • 72 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10622 35
fruit fly
(Drosophila melanogaster)
Insecta CG11526 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea farl-11 35
  • 50.28 (n)
  • 44.15 (a)
farl-11 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAR11 36
  • 13 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1783 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToMany
Species with no ortholog for STRIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRIP2 Gene

ENSEMBL:
Gene Tree for STRIP2 (if available)
TreeFam:
Gene Tree for STRIP2 (if available)

Paralogs for STRIP2 Gene

Paralogs for STRIP2 Gene

(3) SIMAP similar genes for STRIP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STRIP2: view

Variants for STRIP2 Gene

Sequence variations from dbSNP and Humsavar for STRIP2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2242030 - 129,458,324(-) AGGTT(C/T)GTTCT nc-transcript-variant, reference, missense
rs581829 -- 129,454,354(-) CTCAG(A/G)GATGG intron-variant
rs582396 -- 129,475,568(+) ttttt(A/C)ttttt intron-variant
rs586978 -- 129,437,528(+) AGTTT(G/T)TGTGT intron-variant
rs587499 -- 129,437,690(+) ACAGC(A/C)ACAAC intron-variant

Variation tolerance for STRIP2 Gene

Residual Variation Intolerance Score: 7.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.30; 70.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STRIP2 Gene

HapMap Linkage Disequilibrium report
STRIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for STRIP2 Gene

Disorders for STRIP2 Gene

Relevant External Links for STRIP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STRIP2

No disorders were found for STRIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STRIP2 Gene

Publications for STRIP2 Gene

  1. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M. … Gingras A.C. (Mol. Cell. Proteomics 2009) 2 3 4 67
  2. TORC2 signaling is antagonized by protein phosphatase 2A and the Far complex in Saccharomyces cerevisiae. (PMID: 22298706) Pracheil T. … Liu Z. (Genetics 2012) 2 3
  3. The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling. (PMID: 22782902) Lisa-SantamarA-a P. … Revuelta J.L. (J. Biol. Chem. 2012) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3

Products for STRIP2 Gene

Sources for STRIP2 Gene

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