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Aliases for STRIP2 Gene

Aliases for STRIP2 Gene

  • Striatin Interacting Protein 2 2 3
  • Family With Sequence Similarity 40, Member B 2 3
  • Protein FAM40B 3 4
  • FAM40B 3 4
  • FAR11 Factor Arrest 11 Homolog B (Yeast) 2
  • FAR11 Factor Arrest 11 Homolog B 3
  • Homolog Of Yeast FAR11 Protein 2 3
  • Striatin-Interacting Protein 2 3
  • KIAA1170 4
  • FAR11B 3

External Ids for STRIP2 Gene

Previous Symbols for STRIP2 Gene

  • FAM40B

Summaries for STRIP2 Gene

GeneCards Summary for STRIP2 Gene

STRIP2 (Striatin Interacting Protein 2) is a Protein Coding gene. An important paralog of this gene is STRIP1.

UniProtKB/Swiss-Prot for STRIP2 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRIP2 Gene

Genomics for STRIP2 Gene

Genomic Location for STRIP2 Gene

Start:
129,433,890 bp from pter
End:
129,488,399 bp from pter
Size:
54,510 bases
Orientation:
Plus strand

Genomic View for STRIP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STRIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRIP2 Gene

No data available for Regulatory Elements for STRIP2 Gene

Proteins for STRIP2 Gene

  • Protein details for STRIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULQ0-STRP2_HUMAN
    Recommended name:
    Striatin-interacting protein 2
    Protein Accession:
    Q9ULQ0
    Secondary Accessions:
    • Q8WUZ4

    Protein attributes for STRIP2 Gene

    Size:
    834 amino acids
    Molecular mass:
    95360 Da
    Quaternary structure:
    • Component of striatin-interacting phosphatase and kinase (STRIPAK) complex (By similarity). Interacts with CTTNBP2NL.
    SequenceCaution:
    • Sequence=BAA86484.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for STRIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRIP2 Gene

Proteomics data for STRIP2 Gene at MOPED

Post-translational modifications for STRIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys738

Other Protein References for STRIP2 Gene

No data available for DME Specific Peptides for STRIP2 Gene

Domains for STRIP2 Gene

Protein Domains for STRIP2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

STRP2_HUMAN
Family:
  • Belongs to the STRIP family.:
    • Q9ULQ0
genes like me logo Genes that share domains with STRIP2: view

No data available for Gene Families for STRIP2 Gene

Function for STRIP2 Gene

Molecular function for STRIP2 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Gene Ontology (GO) - Molecular Function for STRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with STRIP2: view

Phenotypes for STRIP2 Gene

GenomeRNAi human phenotypes for STRIP2:
genes like me logo Genes that share phenotypes with STRIP2: view

miRNA for STRIP2 Gene

miRTarBase miRNAs that target STRIP2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for STRIP2 Gene

Localization for STRIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRIP2 Gene

Cytoplasm. Note=Enriched in lamellipodia.

Gene Ontology (GO) - Cellular Components for STRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with STRIP2: view

Pathways for STRIP2 Gene

SuperPathways for STRIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP 21834987
GO:0008360 regulation of cell shape IMP 21834987
GO:0016477 cell migration IMP 21834987
genes like me logo Genes that share ontologies with STRIP2: view

No data available for Pathways by source for STRIP2 Gene

Transcripts for STRIP2 Gene

Unigene Clusters for STRIP2 Gene

Striatin interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STRIP2 Gene

No ASD Table

Relevant External Links for STRIP2 Gene

GeneLoc Exon Structure for
STRIP2
ECgene alternative splicing isoforms for
STRIP2

Expression for STRIP2 Gene

mRNA expression in normal human tissues for STRIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STRIP2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (8.2), Brain - Caudate (basal ganglia) (7.9), Brain - Putamen (basal ganglia) (7.4), and Muscle - Skeletal (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for STRIP2 Gene

SOURCE GeneReport for Unigene cluster for STRIP2 Gene Hs.489988

genes like me logo Genes that share expressions with STRIP2: view

Orthologs for STRIP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRIP2 36
  • 99.72 (n)
  • 99.88 (a)
STRIP2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STRIP2 36
  • 92.57 (n)
  • 97.41 (a)
STRIP2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STRIP2 36
  • 93.05 (n)
  • 97.72 (a)
STRIP2 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Strip2 36
  • 90.25 (n)
  • 95.56 (a)
Strip2 16
Strip2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STRIP2 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRIP2 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC500066 36
  • 84.72 (n)
  • 88.57 (a)
chicken
(Gallus gallus)
Aves FAM40B 36
  • 76.57 (n)
  • 82.08 (a)
STRIP2 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRIP2 37
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8705 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15326 36
strip2 36
  • 69.2 (n)
  • 74.11 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10622 36
zebrafish
(Danio rerio)
Actinopterygii Dr.14188 36
LOC556392 36
  • 70.39 (n)
  • 74.97 (a)
strip2 37
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11526 37
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea farl-11 36
  • 50.28 (n)
  • 44.15 (a)
farl-11 37
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAR11 37
  • 13 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1783 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 48 (a)
OneToMany
Species with no ortholog for STRIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRIP2 Gene

ENSEMBL:
Gene Tree for STRIP2 (if available)
TreeFam:
Gene Tree for STRIP2 (if available)

Paralogs for STRIP2 Gene

Paralogs for STRIP2 Gene

Selected SIMAP similar genes for STRIP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STRIP2: view

Variants for STRIP2 Gene

Sequence variations from dbSNP and Humsavar for STRIP2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs581829 -- 129,454,354(-) CTCAG(A/G)GATGG intron-variant
rs582396 -- 129,475,568(+) ttttt(A/C)ttttt intron-variant
rs586978 -- 129,437,528(+) AGTTT(G/T)TGTGT intron-variant
rs587499 -- 129,437,690(+) ACAGC(A/C)ACAAC intron-variant
rs598412 -- 129,487,895(+) TTAAC(A/G)TTTTG utr-variant-3-prime

Relevant External Links for STRIP2 Gene

HapMap Linkage Disequilibrium report
STRIP2

No data available for Structural Variations from Database of Genomic Variants (DGV) for STRIP2 Gene

Disorders for STRIP2 Gene

No disorders were found for STRIP2 Gene.

No data available for UniProtKB/Swiss-Prot for STRIP2 Gene

Publications for STRIP2 Gene

  1. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M. … Gingras A.C. (Mol. Cell. Proteomics 2009) 2 3 4
  2. TORC2 signaling is antagonized by protein phosphatase 2A and the Far complex in Saccharomyces cerevisiae. (PMID: 22298706) Pracheil T. … Liu Z. (Genetics 2012) 2 3
  3. The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling. (PMID: 22782902) Lisa-SantamarA-a P. … Revuelta J.L. (J. Biol. Chem. 2012) 2 3
  4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for STRIP2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate STRIP2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for STRIP2
    • Block miRNA regulation of STRIP2 using miScript Target Protectors

    Sources for STRIP2 Gene

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