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Aliases for STRIP1 Gene

Aliases for STRIP1 Gene

  • Striatin Interacting Protein 1 2 3 5
  • Family With Sequence Similarity 40, Member A 2 3
  • Protein FAM40A 3 4
  • FAM40A 3 4
  • FAR11 Factor Arrest 11 Homolog A (Yeast) 2
  • FAR11 Factor Arrest 11 Homolog A 3
  • Homolog Of Yeast FAR11 Protein 1 3
  • KIAA1761 4
  • FAR11A 3

External Ids for STRIP1 Gene

Previous HGNC Symbols for STRIP1 Gene

  • FAM40A

Previous GeneCards Identifiers for STRIP1 Gene

  • GC01P110575
  • GC01P110577
  • GC01P110579

Summaries for STRIP1 Gene

Entrez Gene Summary for STRIP1 Gene

  • This gene encodes a member of the striatin-interacting phosphatase and kinase complex, which is involved in localization of the Golgi body. The encoded protein participates in cytosketelal organization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for STRIP1 Gene

STRIP1 (Striatin Interacting Protein 1) is a Protein Coding gene. An important paralog of this gene is STRIP2.

UniProtKB/Swiss-Prot for STRIP1 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.

Gene Wiki entry for STRIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRIP1 Gene

Genomics for STRIP1 Gene

Regulatory Elements for STRIP1 Gene

Promoters for STRIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STRIP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for STRIP1 Gene

Chromosome:
1
Start:
110,031,577 bp from pter
End:
110,074,641 bp from pter
Size:
43,065 bases
Orientation:
Plus strand

Genomic View for STRIP1 Gene

Genes around STRIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRIP1 Gene

Proteins for STRIP1 Gene

  • Protein details for STRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VSL9-STRP1_HUMAN
    Recommended name:
    Striatin-interacting protein 1
    Protein Accession:
    Q5VSL9
    Secondary Accessions:
    • Q0V925
    • Q5VSL8
    • Q658K2
    • Q6ZV31
    • Q8N598
    • Q96SN2
    • Q9C0A2

    Protein attributes for STRIP1 Gene

    Size:
    837 amino acids
    Molecular mass:
    95576 Da
    Quaternary structure:
    • Component of striatin-interacting phosphatase and kinase (STRIPAK) complex (By similarity). Interacts with CDC42BPB (PubMed:25743393). Interacts with CTTNBP2NL (PubMed:18782753).
    SequenceCaution:
    • Sequence=AAH32644.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STRIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRIP1 Gene

Proteomics data for STRIP1 Gene at MOPED

Post-translational modifications for STRIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STRIP1 Gene

No data available for DME Specific Peptides for STRIP1 Gene

Domains & Families for STRIP1 Gene

Protein Domains for STRIP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STRIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VSL9

UniProtKB/Swiss-Prot:

STRP1_HUMAN :
  • Belongs to the STRIP family.
Family:
  • Belongs to the STRIP family.
genes like me logo Genes that share domains with STRIP1: view

No data available for Gene Families for STRIP1 Gene

Function for STRIP1 Gene

Molecular function for STRIP1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.

Gene Ontology (GO) - Molecular Function for STRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with STRIP1: view

Phenotypes for STRIP1 Gene

genes like me logo Genes that share phenotypes with STRIP1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STRIP1 Gene

Localization for STRIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRIP1 Gene

Cytoplasm. Note=Enriched on the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STRIP1 Gene COMPARTMENTS Subcellular localization image for STRIP1 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with STRIP1: view

Pathways & Interactions for STRIP1 Gene

SuperPathways for STRIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STRIP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for STRIP1 Gene

Drugs & Compounds for STRIP1 Gene

No Compound Related Data Available

Transcripts for STRIP1 Gene

Unigene Clusters for STRIP1 Gene

Striatin interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STRIP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: -
SP3: - - -
SP4:
SP5:
SP6: -
SP7:
SP8: -
SP9:

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22a · 22b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for STRIP1 Gene

GeneLoc Exon Structure for
STRIP1
ECgene alternative splicing isoforms for
STRIP1

Expression for STRIP1 Gene

mRNA expression in normal human tissues for STRIP1 Gene

Protein differential expression in normal tissues from HIPED for STRIP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.3) and CD8 Tcells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STRIP1 Gene



SOURCE GeneReport for Unigene cluster for STRIP1 Gene Hs.584996

genes like me logo Genes that share expression patterns with STRIP1: view

Protein tissue co-expression partners for STRIP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STRIP1 Gene

Orthologs for STRIP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRIP1 36
  • 100 (a)
OneToOne
FAM40A 35
  • 99.52 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia STRIP1 35
  • 92.35 (n)
  • 98.81 (a)
STRIP1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STRIP1 36
  • 98 (a)
OneToOne
FAM40A 35
  • 92.38 (n)
  • 97.84 (a)
mouse
(Mus musculus)
Mammalia Strip1 16
Strip1 36
  • 98 (a)
OneToOne
Strip1 35
  • 91.12 (n)
  • 97.97 (a)
oppossum
(Monodelphis domestica)
Mammalia STRIP1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRIP1 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Strip1 35
  • 91.76 (n)
  • 97.85 (a)
chicken
(Gallus gallus)
Aves STRIP1 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRIP1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia strip1 35
  • 75.88 (n)
  • 89.77 (a)
zebrafish
(Danio rerio)
Actinopterygii strip1 36
  • 85 (a)
OneToMany
strip1 36
  • 85 (a)
OneToMany
fam40a 35
  • 75 (n)
  • 86.56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007902 35
  • 58.62 (n)
  • 56.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11526 35
  • 58.14 (n)
  • 55.19 (a)
CG11526 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea farl-11 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAR11 38
FAR11 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for STRIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRIP1 Gene

ENSEMBL:
Gene Tree for STRIP1 (if available)
TreeFam:
Gene Tree for STRIP1 (if available)

Paralogs for STRIP1 Gene

Paralogs for STRIP1 Gene

(3) SIMAP similar genes for STRIP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STRIP1: view

Variants for STRIP1 Gene

Sequence variations from dbSNP and Humsavar for STRIP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1834 -- 110,039,158(-) CAAGA(A/C)ACCAG intron-variant, upstream-variant-2KB
rs394645 -- 110,030,574(+) TCACT(C/T)TGCAT upstream-variant-2KB
rs450959 -- 110,030,692(+) CAGCC(A/C)CTATG upstream-variant-2KB
rs866362 -- 110,045,611(+) ATGGA(A/G)ATTGT intron-variant
rs904022 -- 110,054,927(+) TTTCT(C/T)TGGAT downstream-variant-500B

Variation tolerance for STRIP1 Gene

Residual Variation Intolerance Score: 6.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STRIP1 Gene

HapMap Linkage Disequilibrium report
STRIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for STRIP1 Gene

Disorders for STRIP1 Gene

Relevant External Links for STRIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STRIP1

No disorders were found for STRIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STRIP1 Gene

Publications for STRIP1 Gene

  1. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M. … Gingras A.C. (Mol. Cell. Proteomics 2009) 2 3 4 67
  2. The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling. (PMID: 22782902) Lisa-SantamarA-a P. … Revuelta J.L. (J. Biol. Chem. 2012) 2 3
  3. TORC2 signaling is antagonized by protein phosphatase 2A and the Far complex in Saccharomyces cerevisiae. (PMID: 22298706) Pracheil T. … Liu Z. (Genetics 2012) 2 3
  4. Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae. (PMID: 12588993) Kemp H.A. … Sprague G.F. (Mol. Cell. Biol. 2003) 2 3
  5. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3

Products for STRIP1 Gene

Sources for STRIP1 Gene

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