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STRC Gene

protein-coding   GIFtS: 44
GCID: GC15M043892

Stereocilin


(Previous symbol: DFNB16)
  See STRC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
stereocilin1 2
DFNB161 2 5

External Ids:    HGNC: 160351   Entrez Gene: 1614972   Ensembl: ENSG000002428667   OMIM: 6064405   UniProtKB: Q7RTU93   

Export aliases for STRC gene to outside databases

Previous GC identifers: GC15U990014 GC15M036787 GC15M041470 GC15M041607 GC15M041679


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STRC Gene:
This gene encodes a protein that is associated with the hair bundle of the sensory hair cells in the inner ear.
The hair bundle is composed of stiff microvilli called stereocilia and is involved with mechanoreception of sound
waves. This gene is part of a tandem duplication on chromosome 15; the second copy is a pseudogene. Mutations in
this gene cause autosomal recessive non-syndromic deafness. (provided by RefSeq, Jul 2008)

GeneCards Summary for STRC Gene:
STRC (stereocilin) is a protein-coding gene. Diseases associated with STRC include catsper-related male infertility, and deafness-infertility syndrome. An important paralog of this gene is OTOA.

UniProtKB/Swiss-Prot: STRC_HUMAN, Q7RTU9
Function: Essential to the formation of horizontal top connectors between outer hair cell stereocilia (By
similarity)

Gene Wiki entry for STRC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STRC gene promoter:
         ER-alpha   GR   NF-1/L   NF-1   Pax-5   p300   Hand1   GR-alpha   E47   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for STRC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STRC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.3   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q15.3

STRC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STRC gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M043892:  view genomic region     (about GC identifiers)

Start:
43,891,596 bp from pter      End:
44,010,458 bp from pter
Size:
118,863 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: STRC_HUMAN, Q7RTU9 (See protein sequence)
Recommended Name: Stereocilin precursor  
Size: 1775 amino acids; 192967 Da

Explore the universe of human proteins at neXtProt for STRC: NX_Q7RTU9

Explore proteomics data for STRC at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn65, Asn202, Asn297, Asn366, Asn427, Asn476, Asn540, Asn565, Asn656, Asn824,
                                 Asn916, Asn964, Asn1179, Asn1274
  • Modification sites at PhosphoSitePlus

  • See STRC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_714544.1  
    ENSEMBL proteins: 
     ENSP00000401513   ENSP00000415991   ENSP00000394866   ENSP00000394755   ENSP00000407303  
     ENSP00000440413  

    STRC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for STRC
    GenScript Custom Purified and Recombinant Proteins Services for STRC
    Novus Biologicals STRC Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STRC

     
    Search eBioscience for Proteins for STRC 

     
    antibodies-online proteins for STRC (2 products) 

     
    Search antibodies-online for peptides for STRC

    STRC Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for STRC
    Novus Biologicals STRC Antibody
    Abcam antibodies for STRC
    Cloud-Clone Corp. Antibodies for STRC
    Search ThermoFisher Antibodies for STRC
    Search LSBio for Antibodies for STRC
    Search antibodies-online for antibodies for STRC 

    STRC Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STRC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STRC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STRC
    Cloud-Clone Corp. CLIAs for STRC
    Search eBioscience for ELISAs for STRC 
    antibodies-online kits for STRC (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR026664 Stereocilin_related
     IPR026061 Stereocilin

    Graphical View of Domain Structure for InterPro Entry Q7RTU9

    ProtoNet protein and cluster: Q7RTU9

    UniProtKB/Swiss-Prot: STRC_HUMAN, Q7RTU9
    Similarity: Belongs to the stereocilin family


    Find genes that share domains with STRC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STRC_HUMAN, Q7RTU9
    Function: Essential to the formation of horizontal top connectors between outer hair cell stereocilia (By
    similarity)

    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Strc):

     hearing/vestibular/ear  nervous system 

    Find genes that share phenotypes with STRC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Strctm1Ugds for STRC

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STRC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STRC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STRC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STRC

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat STRC using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate STRC:
    hsa-miR-4325 hsa-miR-664
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STRC
    Predesigned siRNA for gene silencing in human, mouse, rat STRC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STRC

    Clone
    Products:
         
    OriGene clones in human, mouse for STRC (see all 5)
    OriGene ORF clones in mouse, rat for STRC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STRC (NM_153700)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRC

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STRC
    Browse ESI BIO Cell Lines and PureStem Progenitors for STRC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STRC_HUMAN, Q7RTU9: Cell surface (By similarity). Cell projection, kinocilium (By similarity). Cell projection,
    stereocilium (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009986cell surface IEA--
    GO:0032420stereocilium IEA--
    GO:0032426stereocilium bundle tip ISS--
    GO:0060091kinocilium ISS--

    Find genes that share ontologies with STRC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STRC
    Interactions:

        Search GeneGlobe Interaction Network for STRC

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0050910detection of mechanical stimulus involved in sensory perception of sound IEA--
    GO:0060088auditory receptor cell stereocilium organization ISS--

    Find genes that share ontologies with STRC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STRC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STRC gene: 
    NM_153700.2  

    Unigene Cluster for STRC:

    Stereocilin
    Hs.657395  [show with all ESTs]
    Unigene Representative Sequence: NM_153700
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450892(uc001zsf.3) ENST00000471703 ENST00000448437 ENST00000485556(uc001zse.3)
    ENST00000428650 ENST00000440125(uc010bdl.3 uc010udz.1) ENST00000460952
    ENST00000493750 ENST00000455136 ENST00000483250 ENST00000470279 ENST00000432436(uc001zsg.1)
    ENST00000541030
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STRC using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate STRC:
    hsa-miR-4325 hsa-miR-664
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STRC
    Predesigned siRNA for gene silencing in human, mouse, rat STRC
    Clone
    Products:
         
    OriGene clones in human, mouse for STRC (see all 5)
    OriGene ORF clones in mouse, rat for STRC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STRC (NM_153700)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRC
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for STRC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STRC
      QuantiTect SYBR Green Assays in human, mouse, rat STRC
      QuantiFast Probe-based Assays in human, mouse, rat STRC

    Additional mRNA sequence: 

    AK090757.1 AK122814.1 AK124582.1 AK126721.1 AK296993.1 AK308370.1 BC129931.1 BC129932.1 

    11 DOTS entries:

    DT.65287568  DT.101980208  DT.121025327  DT.91663512  DT.101980209  DT.121024855  DT.91998301  DT.98083425 
    DT.95356186  DT.121025062  DT.40217998 

    14 AceView cDNA sequences:

    AK122814 BQ082401 AK124582 BK000138 NM_153700 BG413427 BQ082385 AK090757 
    BX419118 BX452064 AX746602 AK126721 BQ082357 BG015585 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STRC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATAAATAT
    STRC Expression
    About this image

    STRC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STRC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657395
        Custom PCR Arrays for STRC
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for STRC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STRC
    QuantiTect SYBR Green Assays in human, mouse, rat STRC
    QuantiFast Probe-based Assays in human, mouse, rat STRC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for STRC gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Strc1 , 5 stereocilin1, 5 86.46(n)1
    88.16(a)1
      2 (60.37 cM)5
    1404761  NM_080459.21  NP_536707.21 
     1213637285 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia strc1 stereocilin 49.08(n)
    39.16(a)
      100493095  XM_002932262.2  XP_002932308.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000044991 stereocilin-like 46.7(n)
    36.87(a)
      100004499  XM_001343756.3  XP_001343792.4 


    ENSEMBL Gene Tree for STRC (if available)
    TreeFam Gene Tree for STRC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STRC gene
    OTOA2  
    1 SIMAP similar gene for STRC using alignment to 8 protein entries:     STRC_HUMAN (see all proteins):
    STRCP1

    Find genes that share paralogs with STRC           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for STRC
    PGOHUM00000262904


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    5 SNPs for STRC    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs29207911,2,4
    ----see VAR_0513892 mis40--------
    rs39877841,2
    ----43903199(-) cacac-/ACA   
      C
    /CACA
    ACAAC
    1 -- int10--------
    rs3724951381,2
    ----43903846(+) ATCCCC/TAGTAA 1 -- int10--------
    rs1397871811,2
    ----43904780(+) GATGGC/TATGGG 1 -- int10--------
    rs752870041,2
    ----43894857(+) TTTTTG/TTTTGA 1 -- int11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for STRC (43891596 - 44010458 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STRC (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749626CNV Deletion23290073
    esv2421427CNV Deletion20811451
    nsv509569CNV Insertion20534489
    nsv1514CNV Loss18451855
    dgv2374n71CNV Loss21882294
    dgv2373n71CNV Loss21882294
    nsv428304CNV Loss18775914
    esv33424CNV Loss17666407
    nsv437799CNV Loss16327808
    nsv9250CNV Loss18304495

    Human Gene Mutation Database (HGMD): STRC
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STRC
    DNA2.0 Custom Variant and Variant Library Synthesis for STRC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606440   
    OMIM disorders: 603720  
    UniProtKB/Swiss-Prot: STRC_HUMAN, Q7RTU9
  • Deafness, autosomal recessive, 16 (DFNB16) [MIM:603720]: A form of non-syndromic sensorineural hearing
    loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to
    the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Deafness-infertility syndrome (DIS) [MIM:611102]: Characterized by deafness and infertility and is caused
    by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 9 diseases for STRC:    
    About MalaCards
    catsper-related male infertility    deafness-infertility syndrome    deafness, autosomal recessive 16    dfnb16 nonsyndromic hearing loss and deafness
    deafness and male infertility    deafness and hereditary hearing loss    sensorineural hearing loss    male infertility
    deafness, autosomal recessive 76

    2 diseases from the University of Copenhagen DISEASES database for STRC:
    Nonsyndromic deafness     Sensorineural hearing loss

    Find genes that share disorders with STRC           About GenesLikeMe


    Export disorders for STRC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STRC gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with STRC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus. (PubMed id 11687802)1, 2, 3, 9 Verpy E.... Petit C. (Nat. Genet. 2001)
    2. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (Nature 2006)
    3. A new locus for non-syndromal, autosomal recessive, sensorineural hearing loss (DFNB16) maps to human chromosome 15q21-q22. (PubMed id 9429146)1, 3 Campbell D.A....Mueller R.F. (J. Med. Genet. 1997)
    4. Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear. (PubMed id 12445334)1, 9 Jovine L....Wassarman P.M. (BMC Cell Biol. 2002)
    5. Genome-wide SNP genotyping identifies the Stereocilin (STRC) gene as a major contributor to pediatric bilateral sensorineural hearing impairment. (PubMed id 22147502)1 Francey L.J....Krantz I.D. (Am. J. Med. Genet. A 2012)
    6. Sensorineural deafness and male infertility: a contiguous gene deletion syndrome. (PubMed id 17098888)2 Zhang Y.... Smith R.J.H. (J. Med. Genet. 2007)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Hereditary deafness and phenotyping in humans. (PubMed id 12324385)1 Bitner-Glindzicz M. (Br. Med. Bull. 2002)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Deafness locus DFNB16 is located on chromosome 15q13-q21 within a 5-cM interval flanked by markers D15S994 and D15S132. (PubMed id 10090914)1 Villamar M....Moreno F. (Am. J. Hum. Genet. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 161497 HGNC: 16035 AceView: STRC Ensembl:ENSG00000242866 euGenes: HUgn161497
    ECgene: STRC H-InvDB: STRC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STRC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STRC gene:
    Search GeneIP for patents involving STRC

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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