STRBP Gene
protein-coding GIFtS: 47
GC09M124926
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spermatid perinuclear RNA binding protein (Previous names: spermatid perinuclear RNA-binding protein, interleukin enhancer binding factor 3-like ) Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: ILF3L)
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Aliases & Descriptions for STRBP
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
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| Aliases |
|---|
| DKFZp434N214 2 | | FLJ11307 1, 2 | | FLJ14223 2 | | FLJ14984 2 | | ILF3L 2 | | MGC21529 2 | | MGC3405 2 | | SPNR 1, 2, 3, 5 | | p74 2, 5 |
| | | Descriptions |
|---|
| interleukin enhancer binding factor 3-like 1, 2 | | spermatid perinuclear RNA binding protein 2 | | spermatid perinuclear RNA-binding protein 1, 2 |
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| | Search outside databases for aliases for STRBP genePrevious GC identifers: GC09M116991 GC09M117533 GC09M119340 GC09M121263 GC09M122966 |
Summaries for STRBP(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: STRBP_HUMAN, Q96SI9Function: Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity)Gene Wiki entry for STRBP |
Genomic Location for STRBP
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the STRBP gene 
Entrez Gene cytogenetic band: 9q33.3 Ensembl cytogenetic band: 9q33.2 HGNC cytogenetic band: 9q33.1-q33.3STRBP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M124926:
(about GC identifiers)
Start:
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124,927,139 bp from pter |
End:
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125,070,718 bp from pter |
Size:
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143,580 bases |
Orientation:
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minus strand |
RefSeq DNA sequence:- NC_000009.10 NT_008470.18
| Proteins for STRBP
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: STRBP_HUMAN, Q96SI9 (See
protein sequence)Recommended Name: Spermatid perinuclear RNA-binding protein Size: 672 amino acids; 73653 Da
Subunit: Interacts with EIF2AK2 (By similarity). Associates with microtubules; it is unsure whether such interaction is direct or indirect (By similarity)
Subcellular location: Cytoplasm (By similarity). Note=Microtubule-associated that localizes to the manchette in developing spermatids (By similarity)
Sequence caution: Sequence=AAI08732.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
PDB structures from and Proteopedia :2DMY (3D)
 
Secondary accessions: Q32NB9 Q9BUE1 Q9BXG4 Q9H0B4 Q9H7V1 Q9NUK4Alternative splicing: 2 isoforms: Q96SI9-1 Q96SI9-2 REFSEQ proteins: NP_060857.2
ENSEMBL proteins: ENSP00000384292 ENSP00000354271 ENSP00000321347 ENSP00000362741
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for STRBP: Assays for STRBP: | Protein
Domains/ Families for STRBP(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96SI9
ProtoNet protein and cluster: Q96SI9 1 Blocks protein family: IPB001159 Double-stranded RNA binding (DsRBD) domain
UniProtKB/Swiss-Prot: STRBP_HUMAN, Q96SI9Similarity: Contains 2 DRBM (double-stranded RNA-binding) domainsSimilarity: Contains 1 DZF domain | Gene Function for STRBP
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018387
Applied Biosystems Silencer® siRNAs for STRBP
Sigma-Aldrich siRNA for STRBP  Sigma-Aldrich shRNA for STRBP  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018387                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018387                                  untagged cDNA clones in CMV expression vector (see all 2): NM_018387 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018387
UniProtKB/Swiss-Prot: STRBP_HUMAN, Q96SI9Function: Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity)7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Strbp):
3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0003677 | DNA binding |
IEA | -- | | GO:0003725 | double-stranded RNA binding |
IEA | -- | | GO:0003727 | single-stranded RNA binding |
IEA | -- | About this table | Pathways & Interactions for STRBP
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for STRBP (Your Favorite Gene powered by Ingenuity) 
--5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): About this table
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Drugs & Compounds for STRBP(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
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Browse Tocris compounds for STRBP
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Transcripts for STRBP(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018387
Sigma-Aldrich siRNA for STRBP  Sigma-Aldrich shRNA for STRBP  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_018387 REFSEQ mRNAs for STRBP gene: NM_018387.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018387               OriGene GFP tagged cDNA clone in CMV expression vector: NM_018387                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018387                                  untagged cDNA clones in CMV expression vector (see all 2): NM_018387  Additional cDNA sequence: AF251293.1 AF333337.1 AJ420426.1 AK002169.1 AK024285.1 AK024960.1 AK025613.1 AK025814.1 AK027890.1 AK123844.1 AL136866.1 AL833947.1 AL834150.1 BC002693.2 BC015678.2 BC017732.1 BC034918.1 BC108731.1 BX648949.1 CR596677.1 CR621060.1 CR749230.1 19 DOTS entries: DT.444482 DT.415090 DT.99931232 DT.100782399 DT.100782400 DT.100782398 DT.100709160 DT.92436090 DT.121150632 DT.95371425 DT.99948231 DT.121150622 DT.40227886 DT.426264 DT.70102331 DT.91680706 DT.95371424 DT.95371429 DT.99972566 24/263 AceView cDNA sequences (see all 263
):CR621060 BG113333 AU132215 BM728734 BG315203 BM704833 NM_018387 AI052160 BM721286 BG107710 AI283608 AW183150 AA860278 BE244997 AK027890 AI025833 CB135362 BM677019 AA741505 BM904147 BX118038 AI912060 BE388898 CR596677
highest scoring ESTs for STRBP:AA984061 AI820049 AK027890 AL136866 AL833947 AL834150 BC017732 BI118160 BQ225405 BU179067 Unigene Cluster for STRBP: Spermatid perinuclear RNA binding protein Hs.708072 [show with all ESTs]Unigene Representative Sequence: CR749230
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for STRBP
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | |
| SP1: | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for STRBP
4 Ensembl transcripts including schematic representations: ENST00000407982
ENST00000360998
ENST00000348403
ENST00000373638
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Expression for STRBP
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| STRBP expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for STRBP
1 / 2 / 3 10 probe-sets matching STRBP gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.708072
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Orthologs for STRBP
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for STRBP gene from 5/9 species (see all 9
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About this table Species with no ortholog for STRBP
ENSEMBL Gene Tree for STRBP | Paralogs for STRBP(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for STRBP gene
- ILF22
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SNPs/Variants for STRBP(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
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HapMap Linkage Disequilibrium images for STRBP (up to first 250kb)
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Disorders & Mutations for STRBP
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
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OMIM: 611138
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Medical News for STRBP(Possibly Related Articles in
Doctor's Guide)
About This Section
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Publications for STRBP (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/19 PubMed articles for STRBP gene (see all 19
):- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)3, 4 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)3, 4 Wiemann S.... Poustka A. (2001)
- Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities. (PubMed id 11336498)1, 3 Pires-daSilva A....Gruss P. (2001)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)4 Sjoeblom T.... Velculescu V.E. (2006)
- The LIFEdb database in 2006. (PubMed id 16381901)3 Mehrle A....Wiemann S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)3 Rual J.F....Vidal M. (2005)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)3 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
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Search for STRBP
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing STRBP
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing STRBP
(According to HUGE)
About This Section
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Specialized Databases showing STRBP(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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| About This Section
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| Services for STRBP(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for STRBP:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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