Aliases for STRBP Gene
Aliases for STRBP Gene
External Ids for STRBP Gene
- HGNC: 16462
- Entrez Gene: 55342
- Ensembl: ENSG00000165209
- OMIM: 611138
- UniProtKB: Q96SI9
Previous HGNC Symbols for STRBP Gene
- ILF3L
Previous GeneCards Identifiers for STRBP Gene
- GC09M116991
- GC09M117533
- GC09M119340
- GC09M121263
- GC09M122966
- GC09M124926
- GC09M125871
- GC09M095498
Summaries for STRBP Gene
GeneCards Summary for STRBP Gene
STRBP (Spermatid Perinuclear RNA Binding Protein) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and single-stranded RNA binding. An important paralog of this gene is ZFR.
UniProtKB/Swiss-Prot for STRBP Gene
-
Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3-UTR and adenovirus VA RNA (By similarity).
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRBP Gene
Genomics for STRBP Gene
Regulatory Elements for STRBP Gene
Enhancers for STRBP Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around STRBP on UCSC Golden Path with GeneCards custom track
Promoters for STRBP Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around STRBP on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the STRBP gene promoter:
Regulatory Element Products
Genomic Location for STRBP Gene
- Chromosome:
- 9
- Start:
- 123,109,494 bp from pter
- End:
- 123,268,576 bp from pter
- Size:
- 159,083 bases
- Orientation:
- Minus strand
Genomic View for STRBP Gene
Genes around STRBP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q33.3 by Ensembl
- 9q33.3 by Entrez Gene
- 9q33.1-q33.3 by HGNC
STRBP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STRBP Gene
Proteins for STRBP Gene
-
Protein details for STRBP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96SI9-STRBP_HUMAN
- Recommended name:
- Spermatid perinuclear RNA-binding protein
- Protein Accession:
- Q96SI9
- Q32NB9
- Q9BUE1
- Q9BXG4
- Q9H0B4
- Q9H7V1
- Q9NUK4
Protein attributes for STRBP Gene
- Size:
- 672 amino acids
- Molecular mass:
- 73653 Da
- Quaternary structure:
-
- Interacts with EIF2AK2. Associates with microtubules; it is unsure whether such interaction is direct or indirect.
- SequenceCaution:
-
- Sequence=AAI08732.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA92120.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14873.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for STRBP Gene
Post-translational modifications for STRBP Gene
Other Protein References for STRBP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for STRBP
- Novus Biologicals Antibodies for STRBP
- Invitrogen Antibodies for STRBP
- antibodies-online Antibodies for STRBP: See all 8
- GeneTex STRBP antibody for STRBP
-
Santa Cruz Biotechnology (SCBT) Antibodies for STRBP
Protein Products
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- Novus Biologicals proteins for STRBP
- antibodies-online Proteins for STRBP: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for STRBP
Assay Products
- antibodies-online Kits for STRBP: See all 7
No data available for DME Specific Peptides for STRBP Gene
Domains & Families for STRBP Gene
Protein Domains for STRBP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for STRBP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96SI9- Domain:
-
- Contains 2 DRBM (double-stranded RNA-binding) domains.
- Contains 1 DZF domain.
No data available for Gene Families for STRBP Gene
Function for STRBP Gene
Molecular function for STRBP Gene
- UniProtKB/Swiss-Prot Function:
- Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3-UTR and adenovirus VA RNA (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003725 | double-stranded RNA binding | IEA | -- |
Phenotypes for STRBP Gene
- MGI mutant phenotypes for STRBP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for STRBP:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for STRBP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for STRBP gene
- Search ViGene Biosciences for STRBP
CRISPR Products
-
OriGene CRISPR knockouts for STRBP
-
Santa Cruz Biotechnology (SCBT) CRISPR for STRBP
- GenScript: Design CRISPR guide RNA sequences for STRBP
miRNA for STRBP Gene
- miRTarBase miRNAs that target STRBP
-
- hsa-mir-375 (MIRT019861)
- hsa-mir-130b-3p (MIRT020149)
- hsa-mir-155-5p (MIRT020761)
- hsa-mir-33a-5p (MIRT028221)
- hsa-mir-21-5p (MIRT030912)
- hsa-mir-92b-3p (MIRT040658)
- hsa-mir-3148 (MIRT402814)
- hsa-mir-6124 (MIRT402817)
- hsa-mir-3591-5p (MIRT541030)
- hsa-mir-3941 (MIRT541031)
- hsa-mir-142-3p (MIRT541032)
- hsa-mir-216b-3p (MIRT541033)
- hsa-mir-4280 (MIRT541034)
- hsa-mir-603 (MIRT541035)
- hsa-mir-362-3p (MIRT541036)
- hsa-mir-329-3p (MIRT541037)
- hsa-mir-8485 (MIRT541038)
- hsa-mir-7977 (MIRT560034)
- hsa-mir-1468-3p (MIRT560035)
- hsa-mir-20a-3p (MIRT560036)
- hsa-mir-545-3p (MIRT560037)
- hsa-mir-4686 (MIRT560038)
- hsa-mir-8063 (MIRT560039)
- hsa-mir-34c-3p (MIRT560040)
- hsa-mir-548p (MIRT560041)
- hsa-mir-34b-3p (MIRT560042)
- hsa-mir-5096 (MIRT666032)
- hsa-mir-3978 (MIRT666033)
- hsa-mir-211-5p (MIRT666034)
- hsa-mir-204-5p (MIRT666035)
- hsa-mir-7106-3p (MIRT666036)
- hsa-mir-4685-3p (MIRT666037)
- hsa-mir-570-3p (MIRT666038)
- hsa-mir-4287 (MIRT666039)
- hsa-mir-6832-3p (MIRT666040)
- hsa-mir-6736-3p (MIRT666041)
- hsa-mir-3613-5p (MIRT720990)
- hsa-mir-4742-3p (MIRT720991)
- hsa-mir-6826-5p (MIRT720992)
- hsa-mir-1183 (MIRT720993)
miRNA Products
- Search ViGene Biosciences for STRBP
Clone Products
- OriGene clones in human for STRBP
- OriGene ORF clones in human,mouse,rat for STRBP
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for STRBP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for STRBP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for STRBP gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STRBP Gene
Localization for STRBP Gene
Subcellular locations from UniProtKB/Swiss-Prot for STRBP Gene
- Cytoplasm. Note=Microtubule-associated that localizes to the manchette in developing spermatids. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 3 |
| cytosol | 2 |
| extracellular | 1 |
No data available for Gene Ontology (GO) - Cellular Components for STRBP Gene
Pathways & Interactions for STRBP Gene
More details on SuperPathways for STRBP
No Data Available
Interacting Proteins for STRBP Gene
Selected Interacting proteins:
Q96SI9-STRBP_HUMAN
ENSP00000321347
for STRBP Gene via
MINT
STRING
UniProtKB
I2D
No data available for Pathways by source and SIGNOR curated interactions for STRBP Gene
Transcripts for STRBP Gene
mRNA/cDNA for STRBP Gene
- (5) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (263) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for STRBP Gene
CRISPR Products
-
OriGene CRISPR knockouts for STRBP
-
Santa Cruz Biotechnology (SCBT) CRISPR for STRBP
- GenScript: Design CRISPR guide RNA sequences for STRBP
miRNA Products
- Search ViGene Biosciences for STRBP
Clone Products
- OriGene clones in human for STRBP
- OriGene ORF clones in human,mouse,rat for STRBP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - |
Expression for STRBP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
This gene is overexpressed in Blymphocyte (9.6), Lung (9.3), Testis (8.6), and Fetal Brain (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STRBP Gene
SOURCE GeneReport for Unigene cluster for STRBP Gene Hs.694157
- Elite partner
Primer Products
-
OriGene qPCR primer pairs and template standards for STRBP
-
OriGene qPCR primer pairs for STRBP
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STRBP Gene
Orthologs for STRBP Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | STRBP 35 |
|
||
| STRBP 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | STRBP 35 |
|
||
| STRBP 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Strbp 35 |
|
||
| Strbp 16 |
|
||||
| Strbp 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | STRBP 35 |
|
||
| STRBP 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Strbp 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | STRBP 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | STRBP 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | STRBP 35 |
|
||
| STRBP 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | STRBP 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.15971 35 |
|
||
| strbp 35 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | strbp 35 |
|
||
| strbp 36 |
|
OneToOne | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8316 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | Y95B8A.8 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
ManyToMany |
- Species with no ortholog for STRBP:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for STRBP Gene
(4) SIMAP similar genes for STRBP Gene using alignment to 5 proteins:
Variants for STRBP Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035662 | A breast cancer sample | ||||
| rs700091 | -- | 123,118,549(-) | GACTT(C/T)TTTGC | intron-variant, nc-transcript-variant | |
| rs700092 | -- | 123,118,650(-) | AGAAA(C/T)ACTTG | intron-variant, nc-transcript-variant | |
| rs700093 | -- | 123,141,982(-) | aggcc(A/C)aagga | intron-variant | |
| rs700094 | -- | 123,148,915(-) | AATCA(A/G)TTCAG | intron-variant |
Residual Variation Intolerance Score:
13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.29;
25.74% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STRBP Gene
Disorders for STRBP Gene
Relevant External Links for STRBP
No disorders were found for STRBP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STRBP Gene
Publications for STRBP Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
- Screening of LRRK2 interactants by yeast 2-hybrid analysis. (PMID: 19001729) Zheng X.Y. … Zhang Z.H. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2008) 3 23
- Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities. (PMID: 11336498) Pires-daSilva A. … Gruss P. (Dev. Biol. 2001) 3 23
- Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
- Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
Products for STRBP Gene
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- Custom Antibody ServicesOriGene Antibodies for STRBP
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- Custom Assay Services
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- OriGene qPCR primer pairs for STRBP
- OriGene qPCR primer pairs and template standards for STRBP
- OriGene CRISPR knockouts for STRBP
- OriGene clones in human for STRBP
- OriGene ORF clones in human,mouse,rat for STRBP
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for STRBP: See all 8
- antibodies-online Kits for STRBP: See all 7
- antibodies-online Proteins for STRBP: See all 5
- Search antibodies-online for peptides
- GeneTex STRBP antibody for STRBP
- Search GeneTex for Proteins for STRBP
- ViGene Biosciences adenoviral particle packaged cDNA for STRBP gene
- ViGene Biosciences lentiviral particle packaged cDNA for STRBP gene
- ViGene Biosciences lentiviral particle packaged cDNA for STRBP gene
- ViGene Biosciences ready-to-package AAV shRNAs for STRBP gene
- ViGene Biosciences ready-to-package AAV shRNAs for STRBP gene
- ViGene Biosciences ready-to-package AAV shRNAs for STRBP gene
- Search ViGene Biosciences for STRBP
- Search ViGene Biosciences for STRBP
- Santa Cruz Biotechnology (SCBT) Antibodies for STRBP
- Search Santa Cruz Biotechnology (SCBT) for STRBP siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for STRBP
Sources for STRBP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon