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Aliases for STRBP Gene

Aliases for STRBP Gene

  • Spermatid Perinuclear RNA Binding Protein 2 3 5
  • Spermatid Perinuclear RNA-Binding Protein 2 3
  • SPNR 3 4
  • Interleukin Enhancer Binding Factor 3-Like 2
  • Epididymis Luminal Protein 162 3
  • HEL162 3
  • ILF3L 3
  • P74 3

External Ids for STRBP Gene

Previous HGNC Symbols for STRBP Gene

  • ILF3L

Previous GeneCards Identifiers for STRBP Gene

  • GC09M116991
  • GC09M117533
  • GC09M119340
  • GC09M121263
  • GC09M122966
  • GC09M124926
  • GC09M125871
  • GC09M095498

Summaries for STRBP Gene

GeneCards Summary for STRBP Gene

STRBP (Spermatid Perinuclear RNA Binding Protein) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and single-stranded RNA binding. An important paralog of this gene is ILF3.

UniProtKB/Swiss-Prot for STRBP Gene

  • Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3-UTR and adenovirus VA RNA (By similarity).

Gene Wiki entry for STRBP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRBP Gene

Genomics for STRBP Gene

Regulatory Elements for STRBP Gene

Enhancers for STRBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F123355 1.3 Ensembl ENCODE 15.9 -89.9 -89945 6.2 HDGF ATF1 CREB3L1 MLX ZFP64 ARID4B ZNF48 GLIS2 GATA2 KDM4B STRBP MIR601 DENND1A MIR600 MIR600HG CRB2 GC09P123401
GH09F123304 1.3 Ensembl ENCODE 11.2 -36.3 -36325 1.5 PKNOX1 ATF1 ARNT ZNF48 GLIS2 ELK1 GATA2 KLF7 KLF13 NCOA1 ZBTB26 ENSG00000261094 STRBP ZBTB6 MIR600 MIR600HG GC09M123300 LOC105376265
GH09F123302 1.1 Ensembl ENCODE 11.4 -34.3 -34316 1.1 HDGF HDAC1 TBL1XR1 ZBTB40 NCOA1 ZEB2 ELF1 SMARCA4 GLIS1 ZNF341 STRBP MIR600 MIR600HG GC09M123300 LOC105376265
GH09F123224 1 Ensembl ENCODE 11.6 +42.9 42930 2.2 CTCF CHD4 ZMYM3 RAD21 RELA CBX5 EED SMC3 CREM ZNF652 STRBP MIR600 MIR600HG RABGAP1 GC09M123162 PIR44660
GH09F123173 1.1 Ensembl ENCODE 10.5 +93.3 93285 4.2 TBP PKNOX1 MXI1 TBL1XR1 BMI1 RELA YY1 CBX5 POLR2A SCRT2 MIR600 MIR600HG STRBP RABGAP1 PIR44660 GC09M123162
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STRBP on UCSC Golden Path with GeneCards custom track

Promoters for STRBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001313742 176 2001 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GLIS2 ELK1 ZNF143

Genomic Location for STRBP Gene

Chromosome:
9
Start:
123,109,494 bp from pter
End:
123,268,576 bp from pter
Size:
159,083 bases
Orientation:
Minus strand

Genomic View for STRBP Gene

Genes around STRBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRBP Gene

Proteins for STRBP Gene

  • Protein details for STRBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SI9-STRBP_HUMAN
    Recommended name:
    Spermatid perinuclear RNA-binding protein
    Protein Accession:
    Q96SI9
    Secondary Accessions:
    • Q32NB9
    • Q9BUE1
    • Q9BXG4
    • Q9H0B4
    • Q9H7V1
    • Q9NUK4

    Protein attributes for STRBP Gene

    Size:
    672 amino acids
    Molecular mass:
    73653 Da
    Quaternary structure:
    • Interacts with EIF2AK2. Associates with microtubules; it is unsure whether such interaction is direct or indirect.
    SequenceCaution:
    • Sequence=AAI08732.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA92120.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14873.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STRBP Gene

    Alternative splice isoforms for STRBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRBP Gene

Post-translational modifications for STRBP Gene

  • Ubiquitination at Lys 339
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STRBP Gene

Domains & Families for STRBP Gene

Protein Domains for STRBP Gene

Suggested Antigen Peptide Sequences for STRBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96SI9

UniProtKB/Swiss-Prot:

STRBP_HUMAN :
  • Contains 2 DRBM (double-stranded RNA-binding) domains.
Domain:
  • Contains 2 DRBM (double-stranded RNA-binding) domains.
  • Contains 1 DZF domain.
genes like me logo Genes that share domains with STRBP: view

No data available for Gene Families for STRBP Gene

Function for STRBP Gene

Molecular function for STRBP Gene

UniProtKB/Swiss-Prot Function:
Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3-UTR and adenovirus VA RNA (By similarity).

Gene Ontology (GO) - Molecular Function for STRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0003725 double-stranded RNA binding IEA --
GO:0003727 single-stranded RNA binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with STRBP: view
genes like me logo Genes that share phenotypes with STRBP: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STRBP Gene

Localization for STRBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRBP Gene

Cytoplasm. Note=Microtubule-associated that localizes to the manchette in developing spermatids. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STRBP gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 2

Gene Ontology (GO) - Cellular Components for STRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0015630 microtubule cytoskeleton IEA --
genes like me logo Genes that share ontologies with STRBP: view

Pathways & Interactions for STRBP Gene

SuperPathways for STRBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for STRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0007286 spermatid development IEA --
GO:0007638 mechanosensory behavior IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with STRBP: view

No data available for Pathways by source and SIGNOR curated interactions for STRBP Gene

Transcripts for STRBP Gene

Unigene Clusters for STRBP Gene

Spermatid perinuclear RNA binding protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRBP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2:
SP3: -
SP4: -

Relevant External Links for STRBP Gene

GeneLoc Exon Structure for
STRBP
ECgene alternative splicing isoforms for
STRBP

Expression for STRBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STRBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STRBP Gene

This gene is overexpressed in Blymphocyte (9.6), Lung (9.3), Testis (8.6), and Fetal Brain (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STRBP Gene



Protein tissue co-expression partners for STRBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STRBP Gene:

STRBP

SOURCE GeneReport for Unigene cluster for STRBP Gene:

Hs.694157
genes like me logo Genes that share expression patterns with STRBP: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STRBP Gene

Orthologs for STRBP Gene

This gene was present in the common ancestor of animals.

Orthologs for STRBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRBP 34 35
  • 99.9 (n)
oppossum
(Monodelphis domestica)
Mammalia STRBP 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STRBP 34 35
  • 96.43 (n)
dog
(Canis familiaris)
Mammalia STRBP 34 35
  • 96.28 (n)
mouse
(Mus musculus)
Mammalia Strbp 34 16 35
  • 94.05 (n)
rat
(Rattus norvegicus)
Mammalia Strbp 34
  • 93.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STRBP 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves STRBP 34 35
  • 85.44 (n)
lizard
(Anolis carolinensis)
Reptilia STRBP 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia strbp 34
  • 76.4 (n)
Str.15971 34
zebrafish
(Danio rerio)
Actinopterygii strbp 34 35
  • 70.73 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8316 34
worm
(Caenorhabditis elegans)
Secernentea Y95B8A.8 35
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
ManyToMany
Species where no ortholog for STRBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRBP Gene

ENSEMBL:
Gene Tree for STRBP (if available)
TreeFam:
Gene Tree for STRBP (if available)

Paralogs for STRBP Gene

Paralogs for STRBP Gene

(4) SIMAP similar genes for STRBP Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STRBP: view

Variants for STRBP Gene

Sequence variations from dbSNP and Humsavar for STRBP Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_035662 A breast cancer sample
rs1001774 -- 123,116,679(+) CATCA(C/G)AGAGA intron-variant, upstream-variant-2KB
rs1009852 -- 123,231,151(+) TCAGT(A/G)TTTTT intron-variant
rs10114885 -- 123,156,155(+) AAAGA(A/G)TGGTT intron-variant
rs10121252 -- 123,174,261(+) TAACA(A/C)CCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STRBP Gene

Variant ID Type Subtype PubMed ID
esv1008345 CNV loss 20482838
esv25223 CNV loss 19812545
esv2658555 CNV deletion 23128226
nsv831717 CNV gain 17160897
nsv6706 CNV insertion 18451855
nsv615271 CNV loss 21841781
esv3621689 CNV loss 21293372

Variation tolerance for STRBP Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STRBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STRBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRBP Gene

Disorders for STRBP Gene

Relevant External Links for STRBP

Genetic Association Database (GAD)
STRBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STRBP

No disorders were found for STRBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STRBP Gene

Publications for STRBP Gene

  1. Screening of LRRK2 interactants by yeast 2-hybrid analysis. (PMID: 19001729) Zheng X.Y. … Zhang Z.H. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2008) 3 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for STRBP Gene

Sources for STRBP Gene

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