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Aliases for STRBP Gene

Aliases for STRBP Gene

  • Spermatid Perinuclear RNA Binding Protein 2 3 5
  • SPNR 3 4
  • Interleukin Enhancer Binding Factor 3-Like 2
  • Spermatid Perinuclear RNA-Binding Protein 2
  • Epididymis Luminal Protein 162 3
  • HEL162 3
  • ILF3L 3
  • P74 3

External Ids for STRBP Gene

Previous HGNC Symbols for STRBP Gene

  • ILF3L

Previous GeneCards Identifiers for STRBP Gene

  • GC09M116991
  • GC09M117533
  • GC09M119340
  • GC09M121263
  • GC09M122966
  • GC09M124926
  • GC09M125871
  • GC09M095498

Summaries for STRBP Gene

GeneCards Summary for STRBP Gene

STRBP (Spermatid Perinuclear RNA Binding Protein) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and single-stranded RNA binding. An important paralog of this gene is ZFR.

UniProtKB/Swiss-Prot for STRBP Gene

  • Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3-UTR and adenovirus VA RNA (By similarity).

Gene Wiki entry for STRBP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRBP Gene

Genomics for STRBP Gene

Regulatory Elements for STRBP Gene

Promoters for STRBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STRBP on UCSC Golden Path with GeneCards custom track

Genomic Location for STRBP Gene

Chromosome:
9
Start:
123,109,494 bp from pter
End:
123,268,576 bp from pter
Size:
159,083 bases
Orientation:
Minus strand

Genomic View for STRBP Gene

Genes around STRBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRBP Gene

Proteins for STRBP Gene

  • Protein details for STRBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SI9-STRBP_HUMAN
    Recommended name:
    Spermatid perinuclear RNA-binding protein
    Protein Accession:
    Q96SI9
    Secondary Accessions:
    • Q32NB9
    • Q9BUE1
    • Q9BXG4
    • Q9H0B4
    • Q9H7V1
    • Q9NUK4

    Protein attributes for STRBP Gene

    Size:
    672 amino acids
    Molecular mass:
    73653 Da
    Quaternary structure:
    • Interacts with EIF2AK2. Associates with microtubules; it is unsure whether such interaction is direct or indirect.
    SequenceCaution:
    • Sequence=AAI08732.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA92120.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14873.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STRBP Gene

    Alternative splice isoforms for STRBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRBP Gene

Proteomics data for STRBP Gene at MOPED

Post-translational modifications for STRBP Gene

  • Ubiquitination at Lys 339
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STRBP Gene

Domains & Families for STRBP Gene

Protein Domains for STRBP Gene

Suggested Antigen Peptide Sequences for STRBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96SI9

UniProtKB/Swiss-Prot:

STRBP_HUMAN :
  • Contains 2 DRBM (double-stranded RNA-binding) domains.
Domain:
  • Contains 2 DRBM (double-stranded RNA-binding) domains.
  • Contains 1 DZF domain.
genes like me logo Genes that share domains with STRBP: view

No data available for Gene Families for STRBP Gene

Function for STRBP Gene

Molecular function for STRBP Gene

UniProtKB/Swiss-Prot Function:
Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3-UTR and adenovirus VA RNA (By similarity).

Gene Ontology (GO) - Molecular Function for STRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003725 double-stranded RNA binding IEA --
genes like me logo Genes that share ontologies with STRBP: view
genes like me logo Genes that share phenotypes with STRBP: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STRBP Gene

Localization for STRBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRBP Gene

Cytoplasm. Note=Microtubule-associated that localizes to the manchette in developing spermatids. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STRBP Gene COMPARTMENTS Subcellular localization image for STRBP gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for STRBP Gene

Pathways & Interactions for STRBP Gene

SuperPathways for STRBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for STRBP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for STRBP Gene

Drugs & Compounds for STRBP Gene

No Compound Related Data Available

Transcripts for STRBP Gene

Unigene Clusters for STRBP Gene

Spermatid perinuclear RNA binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STRBP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2:
SP3: -
SP4: -

Relevant External Links for STRBP Gene

GeneLoc Exon Structure for
STRBP
ECgene alternative splicing isoforms for
STRBP

Expression for STRBP Gene

mRNA expression in normal human tissues for STRBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STRBP Gene

This gene is overexpressed in Blymphocyte (9.6), Lung (9.3), Testis (8.6), and Fetal Brain (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STRBP Gene



SOURCE GeneReport for Unigene cluster for STRBP Gene Hs.694157

genes like me logo Genes that share expression patterns with STRBP: view

Protein tissue co-expression partners for STRBP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STRBP Gene

Orthologs for STRBP Gene

This gene was present in the common ancestor of animals.

Orthologs for STRBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRBP 35
  • 99.9 (n)
  • 100 (a)
STRBP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STRBP 36
  • 99 (a)
OneToOne
STRBP 35
  • 96.43 (n)
  • 98.51 (a)
dog
(Canis familiaris)
Mammalia STRBP 35
  • 96.28 (n)
  • 98.66 (a)
STRBP 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Strbp 16
Strbp 35
  • 94.05 (n)
  • 98.96 (a)
Strbp 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STRBP 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRBP 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Strbp 35
  • 93.8 (n)
  • 98.81 (a)
chicken
(Gallus gallus)
Aves STRBP 35
  • 85.44 (n)
  • 92.25 (a)
STRBP 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRBP 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15971 35
strbp 35
  • 76.4 (n)
  • 83.38 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8316 35
zebrafish
(Danio rerio)
Actinopterygii strbp 36
  • 75 (a)
OneToOne
strbp 35
  • 70.73 (n)
  • 79.1 (a)
worm
(Caenorhabditis elegans)
Secernentea Y95B8A.8 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
Species with no ortholog for STRBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRBP Gene

ENSEMBL:
Gene Tree for STRBP (if available)
TreeFam:
Gene Tree for STRBP (if available)

Paralogs for STRBP Gene

Paralogs for STRBP Gene

(4) SIMAP similar genes for STRBP Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STRBP: view

Variants for STRBP Gene

Sequence variations from dbSNP and Humsavar for STRBP Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_035662 A breast cancer sample
rs700095 -- 123,159,986(+) TTTTC(A/C)TGGTA intron-variant
rs700096 -- 123,160,002(-) TGGTG(C/T)CCCCT intron-variant
rs1116218 -- 123,200,916(-) ataac(A/G)agcag intron-variant
rs803723 -- 123,181,840(-) TACTG(A/G/T)TTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STRBP Gene

Variant ID Type Subtype PubMed ID
nsv893825 CNV Gain 21882294
nsv831717 CNV Gain 17160897
esv2658555 CNV Deletion 23128226
nsv6706 CNV Insertion 18451855
nsv893826 CNV Loss 21882294
esv25223 CNV Loss 19812545
esv1008345 CNV Loss 20482838

Variation tolerance for STRBP Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STRBP Gene

HapMap Linkage Disequilibrium report
STRBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRBP Gene

Disorders for STRBP Gene

Relevant External Links for STRBP

Genetic Association Database (GAD)
STRBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STRBP

No disorders were found for STRBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STRBP Gene

Publications for STRBP Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Screening of LRRK2 interactants by yeast 2-hybrid analysis. (PMID: 19001729) Zheng X.Y. … Zhang Z.H. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2008) 3 23
  3. Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities. (PMID: 11336498) Pires-daSilva A. … Gruss P. (Dev. Biol. 2001) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3

Products for STRBP Gene

Sources for STRBP Gene

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