Aliases for STRBP Gene
Aliases for STRBP Gene
External Ids for STRBP Gene
- HGNC: 16462
- Entrez Gene: 55342
- Ensembl: ENSG00000165209
- OMIM: 611138
- UniProtKB: Q96SI9
Previous HGNC Symbols for STRBP Gene
- ILF3L
Previous GeneCards Identifiers for STRBP Gene
- GC09M116991
- GC09M117533
- GC09M119340
- GC09M121263
- GC09M122966
- GC09M124926
- GC09M125871
- GC09M095498
Summaries for STRBP Gene
GeneCards Summary for STRBP Gene
STRBP (Spermatid Perinuclear RNA Binding Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include single-stranded RNA binding. An important paralog of this gene is ILF3.
UniProtKB/Swiss-Prot for STRBP Gene
-
Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3-UTR and adenovirus VA RNA (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRBP Gene
Genomics for STRBP Gene
GeneHancer (GH) Regulatory Elements for STRBP Gene
Promoters and enhancers for STRBP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around STRBP on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for STRBP Gene
Genomic Locations for STRBP Gene
- chr9:123,109,494-123,268,576
- (GRCh38/hg38)
- Size:
- 159,083 bases
- Orientation:
- Minus strand
- chr9:125,871,779-126,030,855
- (GRCh37/hg19)
Genomic View for STRBP Gene
Genes around STRBP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q33.3 by Ensembl
- 9q33.3 by Entrez Gene
- 9q33.1-q33.3 by HGNC
STRBP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STRBP Gene
Proteins for STRBP Gene
-
Protein details for STRBP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96SI9-STRBP_HUMAN
- Recommended name:
- Spermatid perinuclear RNA-binding protein
- Protein Accession:
- Q96SI9
- Q32NB9
- Q9BUE1
- Q9BXG4
- Q9H0B4
- Q9H7V1
- Q9NUK4
Protein attributes for STRBP Gene
- Size:
- 672 amino acids
- Molecular mass:
- 73653 Da
- Quaternary structure:
-
- Interacts with EIF2AK2. Associates with microtubules; it is unsure whether such interaction is direct or indirect.
- SequenceCaution:
-
- Sequence=AAI08732.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA92120.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14873.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for STRBP Gene
Post-translational modifications for STRBP Gene
- Ubiquitination at isoforms=2339
Other Protein References for STRBP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for STRBP
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Protein Products
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- antibodies-online: Search results for 5 available STRBP Proteins ranked by validation data
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Quality Products:
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-
Abcam proteins for STRBP
Assay Products
- antibodies-online: Search results for 5 available STRBP Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for STRBP Gene
Domains & Families for STRBP Gene
Gene Families for STRBP Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for STRBP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for STRBP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for STRBP Gene
Function for STRBP Gene
Molecular function for STRBP Gene
- UniProtKB/Swiss-Prot Function:
- Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3-UTR and adenovirus VA RNA (By similarity).
Phenotypes From GWAS Catalog for STRBP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | IDA,HDA | 22658674 |
| GO:0003725 | double-stranded RNA binding | IEA | -- |
| GO:0003727 | single-stranded RNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for STRBP Gene
- MGI mutant phenotypes for STRBP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for STRBP:
Animal Model Products
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-
-
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-
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CRISPR Products
-
OriGene CRISPR knockouts for STRBP
- genomics-online: gRNA clones - Search results for 104 available STRBP gene related products
- Overview of 104 available STRBP gene related products
- Applied Biological Materials CRISPR for STRBP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STRBP
- GenScript: Design CRISPR guide RNA sequences for STRBP
miRNA for STRBP Gene
- miRTarBase miRNAs that target STRBP
-
- hsa-mir-375 (MIRT019861)
- hsa-mir-130b-3p (MIRT020149)
- hsa-mir-155-5p (MIRT020761)
- hsa-mir-33a-5p (MIRT028221)
- hsa-mir-21-5p (MIRT030912)
- hsa-mir-92b-3p (MIRT040658)
- hsa-mir-3148 (MIRT402814)
- hsa-mir-6124 (MIRT402817)
- hsa-mir-3591-5p (MIRT541030)
- hsa-mir-3941 (MIRT541031)
- hsa-mir-142-3p (MIRT541032)
- hsa-mir-216b-3p (MIRT541033)
- hsa-mir-4280 (MIRT541034)
- hsa-mir-603 (MIRT541035)
- hsa-mir-362-3p (MIRT541036)
- hsa-mir-329-3p (MIRT541037)
- hsa-mir-8485 (MIRT541038)
- hsa-mir-7977 (MIRT560034)
- hsa-mir-1468-3p (MIRT560035)
- hsa-mir-20a-3p (MIRT560036)
- hsa-mir-545-3p (MIRT560037)
- hsa-mir-4686 (MIRT560038)
- hsa-mir-8063 (MIRT560039)
- hsa-mir-34c-3p (MIRT560040)
- hsa-mir-548p (MIRT560041)
- hsa-mir-34b-3p (MIRT560042)
- hsa-mir-5096 (MIRT666032)
- hsa-mir-3978 (MIRT666033)
- hsa-mir-211-5p (MIRT666034)
- hsa-mir-204-5p (MIRT666035)
- hsa-mir-7106-3p (MIRT666036)
- hsa-mir-4685-3p (MIRT666037)
- hsa-mir-570-3p (MIRT666038)
- hsa-mir-4287 (MIRT666039)
- hsa-mir-6832-3p (MIRT666040)
- hsa-mir-6736-3p (MIRT666041)
- hsa-mir-3613-5p (MIRT720990)
- hsa-mir-4742-3p (MIRT720991)
- hsa-mir-6826-5p (MIRT720992)
- hsa-mir-1183 (MIRT720993)
miRNA Products
- Search ViGene Biosciences for STRBP
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STRBP
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- genomics-online: shRNA clones - Search results for 104 available STRBP gene related products
- Overview of 104 available STRBP gene related products
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ViGene Biosciences ready-to-package AAV shRNAs for STRBP gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for STRBP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STRBP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for STRBP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for STRBP
-
ViGene Biosciences adenoviral particle packaged cDNA for STRBP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for STRBP gene
-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STRBP Gene
Localization for STRBP Gene
Subcellular locations from UniProtKB/Swiss-Prot for STRBP Gene
- Cytoplasm. Note=Microtubule-associated that localizes to the manchette in developing spermatids. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 3 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0015630 | microtubule cytoskeleton | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for STRBP Gene
Pathways & Interactions for STRBP Gene
No Data Available
Interacting Proteins for STRBP Gene
Selected Interacting proteins:
Q96SI9-STRBP_HUMAN
ENSP00000321347
for STRBP Gene via
IID
UniProtKB
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | IEA | -- |
| GO:0007286 | spermatid development | IEA | -- |
| GO:0007638 | mechanosensory behavior | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for STRBP Gene
Transcripts for STRBP Gene
mRNA/cDNA for STRBP Gene
- (11) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (263) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for STRBP Gene
CRISPR Products
-
OriGene CRISPR knockouts for STRBP
- genomics-online: gRNA clones - Search results for 104 available STRBP gene related products
- Overview of 104 available STRBP gene related products
- Applied Biological Materials CRISPR for STRBP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STRBP
- GenScript: Design CRISPR guide RNA sequences for STRBP
miRNA Products
- Search ViGene Biosciences for STRBP
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STRBP
- Browse OriGene Inhibitory RNA Products For STRBP
- genomics-online: shRNA clones - Search results for 104 available STRBP gene related products
- Overview of 104 available STRBP gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for STRBP gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for STRBP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STRBP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for STRBP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - |
Expression for STRBP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
This gene is overexpressed in Blymphocyte (9.6), Lung (9.3), Testis (8.6), and Fetal Brain (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STRBP Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of STRBP Gene:
STRBPSOURCE GeneReport for Unigene cluster for STRBP Gene:
Hs.694157Evidence on tissue expression from TISSUES for STRBP Gene
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for STRBP
-
OriGene qPCR primer pairs for STRBP
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STRBP Gene
Orthologs for STRBP Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | STRBP 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | STRBP 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | STRBP 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | STRBP 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Strbp 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Strbp 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | STRBP 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | STRBP 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | STRBP 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | strbp 33 |
|
||
| Str.15971 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | strbp 33 34 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8316 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | Y95B8A.8 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany |
- Species where no ortholog for STRBP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for STRBP Gene
(4) SIMAP similar genes for STRBP Gene using alignment to 5 proteins:
Variants for STRBP Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035662 | A breast cancer sample | p.Gly280Arg | |||
| rs1000007828 | -- | 123,162,001(-) | C/T | intron_variant | |
| rs1000011260 | -- | 123,235,886(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000018521 | -- | 123,128,650(-) | T/A | intron_variant | |
| rs1000029776 | -- | 123,208,111(-) | TGT/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1008345 | CNV | loss | 20482838 |
| esv25223 | CNV | loss | 19812545 |
| esv2658555 | CNV | deletion | 23128226 |
| esv3621689 | CNV | loss | 21293372 |
| nsv615271 | CNV | loss | 21841781 |
| nsv6706 | CNV | insertion | 18451855 |
| nsv831717 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.29;
25.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STRBP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- STRBP
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRBP Gene
Disorders for STRBP Gene
Additional Disease Information for STRBP
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for STRBP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STRBP Gene
Publications for STRBP Gene
- Screening of LRRK2 interactants by yeast 2-hybrid analysis. (PMID: 19001729) Zheng XY … Zhang ZH (Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2008) 3 22 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
Products for STRBP Gene
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- Invitrogen Antibodies for STRBP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for STRBP
- VectorBuilder custom plasmid, inducible vectors for STRBP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STRBP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 14 available STRBP Antibodies ranked by validation data
- Compare Top STRBP Antibodies
- antibodies-online: Search results for 5 available STRBP Elisa Kits ranked by validation data
- Compare Top STRBP Elisa Kits
- Quality Products:
- antibodies-online: Search results for 5 available STRBP Proteins ranked by validation data
- Compare Top STRBP Proteins
- Quality Products:
- GeneTex STRBP antibody for STRBP
- Search GeneTex for Proteins for STRBP
- ViGene Biosciences adenoviral particle packaged cDNA for STRBP gene
- ViGene Biosciences lentiviral particle packaged cDNA for STRBP gene
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- Search ViGene Biosciences for STRBP
- Horizon Cell Lines for STRBP
- genomics-online: cdna clones - Search results for 104 available STRBP gene related products
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- Overview of 104 available STRBP gene related products
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- Overview of 104 available STRBP gene related products
- genomics-online: primer clones - Search results for 104 available STRBP gene related products
- Overview of 104 available STRBP gene related products
- genomics-online: shRNA clones - Search results for 104 available STRBP gene related products
- Overview of 104 available STRBP gene related products
Sources for STRBP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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