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Aliases for STRBP Gene

Aliases for STRBP Gene

  • Spermatid Perinuclear RNA Binding Protein 2 3
  • SPNR 3 4 6
  • Spermatid Perinuclear RNA-Binding Protein 2 3
  • P74 3 6
  • Interleukin Enhancer Binding Factor 3-Like 2
  • Epididymis Luminal Protein 162 3
  • HEL162 3
  • ILF3L 3

External Ids for STRBP Gene

Previous Symbols for STRBP Gene

  • ILF3L

Summaries for STRBP Gene

GeneCards Summary for STRBP Gene

STRBP (Spermatid Perinuclear RNA Binding Protein) is a Protein Coding gene. GO annotations related to this gene include double-stranded RNA binding and single-stranded RNA binding. An important paralog of this gene is ZFR2.

UniProtKB/Swiss-Prot for STRBP Gene

  • Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3-UTR and adenovirus VA RNA (By similarity).

Gene Wiki entry for STRBP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRBP Gene

Genomics for STRBP Gene

Genomic Location for STRBP Gene

Start:
123,109,500 bp from pter
End:
123,268,576 bp from pter
Size:
159,077 bases
Orientation:
Minus strand

Genomic View for STRBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STRBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRBP Gene

Regulatory Elements for STRBP Gene

Proteins for STRBP Gene

  • Protein details for STRBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SI9-STRBP_HUMAN
    Recommended name:
    Spermatid perinuclear RNA-binding protein
    Protein Accession:
    Q96SI9
    Secondary Accessions:
    • Q32NB9
    • Q9BUE1
    • Q9BXG4
    • Q9H0B4
    • Q9H7V1
    • Q9NUK4

    Protein attributes for STRBP Gene

    Size:
    672 amino acids
    Molecular mass:
    73653 Da
    Quaternary structure:
    • Interacts with EIF2AK2. Associates with microtubules; it is unsure whether such interaction is direct or indirect.
    SequenceCaution:
    • Sequence=AAI08732.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA92120.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14873.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STRBP Gene

    Alternative splice isoforms for STRBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRBP Gene

Proteomics data for STRBP Gene at MOPED

Post-translational modifications for STRBP Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys339 and Lys526

No data available for DME Specific Peptides for STRBP Gene

Domains for STRBP Gene

Protein Domains for STRBP Gene

Suggested Antigen Peptide Sequences for STRBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96SI9

UniProtKB/Swiss-Prot:

STRBP_HUMAN
Domain:
  • Contains 2 DRBM (double-stranded RNA-binding) domains.:
    • Q96SI9
  • Contains 1 DZF domain.:
    • Q96SI9
genes like me logo Genes that share domains with STRBP: view

No data available for Gene Families for STRBP Gene

Function for STRBP Gene

Molecular function for STRBP Gene

UniProtKB/Swiss-Prot Function: Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3-UTR and adenovirus VA RNA (By similarity).

Gene Ontology (GO) - Molecular Function for STRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003725 double-stranded RNA binding IEA --
GO:0003727 single-stranded RNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with STRBP: view
genes like me logo Genes that share phenotypes with STRBP: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for STRBP Gene

Localization for STRBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRBP Gene

Cytoplasm. Note=Microtubule-associated that localizes to the manchette in developing spermatids. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STRBP Gene COMPARTMENTS Subcellular localization image for STRBP gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for STRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0015630 microtubule cytoskeleton IEA --
genes like me logo Genes that share ontologies with STRBP: view

Pathways for STRBP Gene

SuperPathways for STRBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for STRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component --
GO:0007275 multicellular organismal development IEA --
GO:0007286 spermatid development IEA --
GO:0007638 mechanosensory behavior IEA --
genes like me logo Genes that share ontologies with STRBP: view

No data available for Pathways by source for STRBP Gene

Transcripts for STRBP Gene

Unigene Clusters for STRBP Gene

Spermatid perinuclear RNA binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STRBP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2:
SP3: -
SP4: -

Relevant External Links for STRBP Gene

GeneLoc Exon Structure for
STRBP
ECgene alternative splicing isoforms for
STRBP

Expression for STRBP Gene

mRNA expression in normal human tissues for STRBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STRBP Gene

SOURCE GeneReport for Unigene cluster for STRBP Gene Hs.694157

genes like me logo Genes that share expressions with STRBP: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STRBP Gene

Orthologs for STRBP Gene

This gene was present in the common ancestor of animals.

Orthologs for STRBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRBP 35
  • 99.9 (n)
  • 100 (a)
STRBP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STRBP 35
  • 96.43 (n)
  • 98.51 (a)
STRBP 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STRBP 35
  • 96.28 (n)
  • 98.66 (a)
STRBP 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Strbp 35
  • 94.05 (n)
  • 98.96 (a)
Strbp 16
Strbp 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STRBP 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRBP 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Strbp 35
  • 93.8 (n)
  • 98.81 (a)
chicken
(Gallus gallus)
Aves STRBP 35
  • 85.44 (n)
  • 92.25 (a)
STRBP 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRBP 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15971 35
strbp 35
  • 76.4 (n)
  • 83.38 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8316 35
zebrafish
(Danio rerio)
Actinopterygii strbp 35
  • 70.73 (n)
  • 79.1 (a)
strbp 36
  • 75 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y95B8A.8 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
Species with no ortholog for STRBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRBP Gene

ENSEMBL:
Gene Tree for STRBP (if available)
TreeFam:
Gene Tree for STRBP (if available)

Paralogs for STRBP Gene

Paralogs for STRBP Gene

Selected SIMAP similar genes for STRBP Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STRBP: view

Variants for STRBP Gene

Sequence variations from dbSNP and Humsavar for STRBP Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs700093 -- 123,141,982(-) aggcc(A/C)aagga intron-variant
rs700094 -- 123,148,915(-) AATCA(A/G)TTCAG intron-variant
rs700095 -- 123,159,986(+) TTTTC(A/C)TGGTA intron-variant
rs700096 -- 123,160,002(-) TGGTG(C/T)CCCCT intron-variant
rs715410 -- 123,157,843(+) CAACA(A/T)GAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STRBP Gene

Variant ID Type Subtype PubMed ID
nsv893825 CNV Gain 21882294
nsv831717 CNV Gain 17160897
esv2658555 CNV Deletion 23128226
nsv6706 CNV Insertion 18451855
nsv893826 CNV Loss 21882294
esv25223 CNV Loss 19812545
esv1008345 CNV Loss 20482838

Relevant External Links for STRBP Gene

HapMap Linkage Disequilibrium report
STRBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRBP Gene

Disorders for STRBP Gene

Relevant External Links for STRBP

Genetic Association Database (GAD)
STRBP
genes like me logo Genes that share disorders with STRBP: view

No data available for UniProtKB/Swiss-Prot for STRBP Gene

Publications for STRBP Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Screening of LRRK2 interactants by yeast 2-hybrid analysis. (PMID: 19001729) Zheng X.Y. … Zhang Z.H. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2008) 3 23
  5. Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities. (PMID: 11336498) Pires-daSilva A. … Gruss P. (Dev. Biol. 2001) 3 23

Products for STRBP Gene

Sources for STRBP Gene

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