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STRBP Gene

protein-coding   GIFtS: 47

GC09M124926
spermatid perinuclear RNA binding protein
(Previous names: spermatid perinuclear RNA-binding protein, interleukin enhancer binding factor 3-like )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ILF3L)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp434N214 2
FLJ11307 1, 2
FLJ14223 2
FLJ14984 2
ILF3L 2
MGC21529 2
MGC3405 2
SPNR 1, 2, 3, 5
p74 2, 5
Descriptions
interleukin enhancer binding factor 3-like 1, 2
spermatid perinuclear RNA binding protein 2
spermatid perinuclear RNA-binding protein 1, 2
External Ids
HGNC: 164621
Entrez Gene: 553422
UniProtKB: Q96SI93
Ensembl: ENSG000001652097
Search outside databases for aliases for STRBP gene

Previous GC identifers: GC09M116991 GC09M117533 GC09M119340 GC09M121263 GC09M122966

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: STRBP_HUMAN, Q96SI9
Function: Involved in spermatogenesis and sperm function. Plays a role in regulation of cell
growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to
poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA
PRM1 3'-UTR and adenovirus VA RNA (By similarity)

Gene Wiki entry for STRBP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the STRBP gene  

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q33.1-q33.3

STRBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M124926:     (about GC identifiers)

Start:
124,927,139 bp from pter
End:
125,070,718 bp from pter
Size:
143,580 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000009.10  NT_008470.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: STRBP_HUMAN, Q96SI9 (See protein sequence)
Recommended Name: Spermatid perinuclear RNA-binding protein  
Size: 672 amino acids; 73653 Da
Subunit: Interacts with EIF2AK2 (By similarity). Associates with microtubules; it is unsure whether
such interaction is direct or indirect (By similarity)
Subcellular location: Cytoplasm (By similarity). Note=Microtubule-associated that localizes to the
manchette in developing spermatids (By similarity)
Sequence caution: Sequence=AAI08732.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.
Potential poly-A sequence;
PDB structures from and Proteopedia :
2DMY (3D)    
Secondary accessions: Q32NB9 Q9BUE1 Q9BXG4 Q9H0B4 Q9H7V1 Q9NUK4
Alternative splicing: 2 isoforms:  Q96SI9-1   Q96SI9-2   

REFSEQ proteins: NP_060857.2  

ENSEMBL proteins: 
ENSP00000384292 ENSP00000354271 ENSP00000321347 ENSP00000362741 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (STRBP)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
GO:0005634 nucleus IDA11256614
GO:0005737 cytoplasm IEA--
GO:0015630 microtubule cytoskeleton IEA--
About this table

Antibodies for STRBP: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for STRBP
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for STRBP

Assays for STRBP: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro domains/families:
 IPR001159 Ds-RNA_bd
 IPR014720 dsRNA-bd-like
 IPR006561 DZF


   GeneDecks  STRBP for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q96SI9

ProtoNet protein and cluster: Q96SI9

1 Blocks protein family: IPB001159 Double-stranded RNA binding (DsRBD) domain

UniProtKB/Swiss-Prot: STRBP_HUMAN, Q96SI9
Similarity: Contains 2 DRBM (double-stranded RNA-binding) domains
Similarity: Contains 1 DZF domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (STRBP)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (STRBP)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018387

              Applied Biosystems Silencer® siRNAs for STRBP

              Sigma-Aldrich siRNA for STRBP  
                     Sigma-Aldrich shRNA for STRBP  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018387
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018387
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_018387 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_018387

UniProtKB/Swiss-Prot: STRBP_HUMAN, Q96SI9
Function: Involved in spermatogenesis and sperm function. Plays a role in regulation of cell
growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to
poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA
PRM1 3'-UTR and adenovirus VA RNA (By similarity)

7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Strbp):

behavior/neurologicalendocrine/exocrine glandgrowth/sizelethality-postnatallife span-post-weaning/aging
nervous systemreproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003677 DNA binding IEA--
GO:0003725 double-stranded RNA binding IEA--
GO:0003727 single-stranded RNA binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for  STRBP  (Your Favorite Gene powered by Ingenuity) 
 TR/RXR Activation

   GeneDecks  STRBP for the pathways selected above  
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  --

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0006928 cell motion IEA--
GO:0007275 multicellular organismal development IEA--
GO:0007283 spermatogenesis IEA--
GO:0007286 spermatid development IEA--
GO:0007638 mechanosensory behavior IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for STRBP

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (STRBP)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (STRBP)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018387

              Sigma-Aldrich siRNA for STRBP  
                     Sigma-Aldrich shRNA for STRBP  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_018387  

REFSEQ mRNAs for STRBP gene: 

NM_018387.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_018387  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018387
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018387
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_018387 

Additional cDNA sequence: 

AF251293.1 AF333337.1 AJ420426.1 AK002169.1 AK024285.1 AK024960.1 AK025613.1 AK025814.1 
AK027890.1 AK123844.1 AL136866.1 AL833947.1 AL834150.1 BC002693.2 BC015678.2 BC017732.1 
BC034918.1 BC108731.1 BX648949.1 CR596677.1 CR621060.1 CR749230.1 

19 DOTS entries:

DT.444482  DT.415090  DT.99931232  DT.100782399  DT.100782400  DT.100782398  DT.100709160  DT.92436090 
DT.121150632  DT.95371425  DT.99948231  DT.121150622  DT.40227886  DT.426264  DT.70102331  DT.91680706 
DT.95371424  DT.95371429  DT.99972566 

24/263 AceView cDNA sequences (see all 263 ):

CR621060 BG113333 AU132215 BM728734 BG315203 BM704833 NM_018387 AI052160 
BM721286 BG107710 AI283608 AW183150 AA860278 BE244997 AK027890 AI025833 
CB135362 BM677019 AA741505 BM904147 BX118038 AI912060 BE388898 CR596677 

highest scoring ESTs for STRBP:

AA984061 AI820049 AK027890 AL136866 AL833947 AL834150 BC017732 BI118160 BQ225405 BU179067 

Unigene Cluster for STRBP:

Spermatid perinuclear RNA binding protein
Hs.708072  [show with all ESTs]
Unigene Representative Sequence: CR749230


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for STRBP

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1:        -                                                                                                                           
SP2:                                                                                                                                    
SP3:                                                                                                  -                                 
SP4:                                                                                                  -                                 

About this scheme

ECgene alternative splicing isoforms for STRBP

4 Ensembl transcripts including schematic representations:
ENST00000407982  ENST00000360998  ENST00000348403  ENST00000373638  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

STRBP expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for STRBP

1 / 2 / 3

10 probe-sets matching STRBP gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
55053_at2, 3 U95-B 1 1.00 1.00 0.92 1.06 AI820049 0.80 1.00 0.91 1
48628_at2, 3 U95-C 1 0.75 1.00 0.96 0.94 AA984061 0.80 1.00 0.91 1

223246_s_at2, 3 U133-B 1 1.00 1.00 -- -- BC002693 0.60 1.00 0.82 1

233252_s_at2, 3 U133-B 1 1.00 1.00 -- -- AK024960 0.40 1.00 0.76 1

223245_at2, 3 U133-B 1 1.00 1.00 -- -- AK024285 0.60 1.00 0.82 1

233251_at*2, 3 U133-B 1 1.00 1.00 -- -- AK024960 0.40 1.00 0.76 1

223246_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

233252_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

223245_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

233251_at*2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  STRBP for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.708072
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for STRBP gene from 5/9 species (see all 9 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
STRBP1   -- spermatid perinuclear RNA binding protein 96.23(n)
98.66(a)
480733  XM_537853.2  XP_537853.1 
chimpanzee
(Pan troglodytes)
STRBP1   -- spermatid perinuclear RNA binding protein 99.85(n)
100(a)
464719  XM_001140028.1  XP_001140028.1 
cow
(Bos taurus)
STRBP1   -- spermatid perinuclear RNA binding protein 96.48(n)
98.51(a)
516282  NM_001075739.1  NP_001069207.1 
rat
(Rattus norvegicus)
Strbp1   -- spermatid perinuclear RNA binding protein 91.69(n)
95.81(a)
84476  NM_053416.1  NP_445868.1 
mouse
(Mus musculus)
Strbp1, 5 25
spermatid perinuclear RNA binding protein1, 5 94(n)1
98.96(a)1
207441  NM_009261.21  NP_033287.21 
 AI8387095  AI8525135  (see all 25)
About this table        Species with no ortholog for STRBP

ENSEMBL Gene Tree for STRBP
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for STRBP gene
ILF22  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/476 NCBI SNPs in STRBP are shown (see all 476 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 138)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 9 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs37398391,2
C,F,H125071671(-) CCGGTG/ATACAG 1 -- ng315Minor allele frequency- A:0.39EA EU WA 1898
rs37398381,2
F,H125071917(-) TGGGTT/CTTTTA 1 -- ng312Minor allele frequency- C:0.01EU WA 240
--
rs109858911,2
C124927444(+) TTTCCC/TTAGAA 1 -- ut310--------
rs8037361,2
A,C,F,H124960197(-) TTTGGC/TCAGAT 1 G/G syn18Minor allele frequency- T:0.44MN NA EU EA WA 744
rs8037371,2
A,C,F,H,O124959549(-) CAGCTG/AATGTA 1 -- int112Minor allele frequency- A:0.04EU EA WA NS NA 662
rs24168991,2
A,C,F,H,O125054924(+) TATTTG/TAACAT 1 -- int17Minor allele frequency- T:0.37NA EU EA WA 560
rs25400741,2
A,C,F,H,O125011317(-) GATATG/ATAGTA 1 -- int17Minor allele frequency- A:0.36EU EA WA NA 558
rs8037281,2
A,C,F,H,O125009476(-) CCAACA/TTTGTT 1 -- int111Minor allele frequency- T:0.19EU EA WA NA 978
rs70443471,2
A,C,F,H124928107(+) TCTCAG/ATGTGG 1 -- int14Minor allele frequency- A:0.36EU EA WA 416
rs78759201,2
A,C,F,H125013485(+) AAAGAG/AGGTGA 1 -- int1 trp311Minor allele frequency- A:0.11EU EA WA NA 972
About this table

HapMap Linkage Disequilibrium images for STRBP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 611138

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/19 PubMed articles for STRBP gene (see all 19 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55342 HGNC: 16462 AceView: STRBPandC9orf45 Ensembl:ENSG00000165209 euGenes: HUgn55342
ECgene: STRBP H-InvDB: STRBP
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for STRBP:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for STRBP-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for STRBP Antibodies for STRBP
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for STRBP Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search Novus for antibodies for STRBP

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