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STRAP Gene

protein-coding   GIFtS: 57
GCID: GC12P016035

Serine/Threonine Kinase Receptor Associated Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Threonine Kinase Receptor Associated Protein1 2     MAP Activator With WD Repeats2 3
UNR-Interacting Protein1 2 3     WD-40 Repeat Protein PT-WD2 3
MAWD2 3 5     PT-WD2
UNRIP2 3 5     Serine-Threonine Kinase Receptor-Associated Protein2

External Ids:    HGNC: 307961   Entrez Gene: 111712   Ensembl: ENSG000000237347   OMIM: 6059865   UniProtKB: Q9Y3F43   

Export aliases for STRAP gene to outside databases

Previous GC identifers: GC12P015927 GC12P015928 GC12P015804


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STRAP Gene:
STRAP (serine/threonine kinase receptor associated protein) is a protein-coding gene. GO annotations related to this gene include receptor binding. An important paralog of this gene is EIF3I.

UniProtKB/Swiss-Prot: STRAP_HUMAN, Q9Y3F4
Function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the
building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most
spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG
that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the
cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by
the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from
the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their
transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively
regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its
autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein

Gene Wiki entry for STRAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the STRAP gene promoter:
         p53   HOXA3   NRSF form 1   Lmo2   Pax-2a   NRSF form 2   Cdc5   c-Ets-1   AREB6   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTRAP promoter sequence
   Search Chromatin IP Primers for STRAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STRAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p13.1

STRAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STRAP gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P016035:  view genomic region     (about GC identifiers)

Start:
16,035,288 bp from pter      End:
16,056,412 bp from pter
Size:
21,125 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: STRAP_HUMAN, Q9Y3F4 (See protein sequence)
Recommended Name: Serine-threonine kinase receptor-associated protein  
Size: 350 amino acids; 38438 Da
Subunit: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6,
GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4,
GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and
SNRPG. Interacts directly with GEMIN6 and GEMIN7. Associates with the SMN complex in the cytoplasm but not in the
nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1
Secondary accessions: B2R5S5 Q5TZT4 Q9NTK0 Q9UQC8

Explore the universe of human proteins at neXtProt for STRAP: NX_Q9Y3F4

Explore proteomics data for STRAP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys59, Lys122, Lys156, Lys298, Lys317
  • Modification sites at PhosphoSitePlus

  • See STRAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009109.3  
    ENSEMBL proteins: 
     ENSP00000445693   ENSP00000025399   ENSP00000392270   ENSP00000445814   ENSP00000439761  
    Reactome Protein details: Q9Y3F4

    STRAP Human Recombinant Protein Products:

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    OriGene Purified Protein for STRAP
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    OriGene MassSpec for STRAP
    OriGene Custom Protein Services for STRAP
    GenScript Custom Purified and Recombinant Proteins Services for STRAP
    Novus Biologicals STRAP Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STRAP

     
    Search eBioscience for Proteins for STRAP 

     
    antibodies-online proteins for STRAP (4 products) 

     
    antibodies-online peptides for STRAP

    STRAP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals STRAP Antibodies
    Abcam antibodies for STRAP
    Cloud-Clone Corp. Antibodies for STRAP
    ThermoFisher Antibody for STRAP
    antibodies-online antibodies for STRAP (32 products) 

    STRAP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for STRAP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STRAP
    Cloud-Clone Corp. CLIAs for STRAP
    Search eBioscience for ELISAs for STRAP 
    antibodies-online kits for STRAP (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y3F4

    ProtoNet protein and cluster: Q9Y3F4

    UniProtKB/Swiss-Prot: STRAP_HUMAN, Q9Y3F4
    Similarity: Belongs to the WD repeat STRAP family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with STRAP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STRAP_HUMAN, Q9Y3F4
    Function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the
    building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most
    spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG
    that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the
    cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by
    the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from
    the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their
    transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively
    regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its
    autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0005515protein binding IPI17314099
    GO:0016301kinase activity ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with STRAP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STRAP:
     Increased TP53 protein express 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Strap):
     cardiovascular system  embryogenesis  mortality/aging  nervous system 

    Find genes that share phenotypes with STRAP           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for STRAP

    miRNA
    Products:
        
    miRTarBase miRNAs that target STRAP:
    hsa-mir-374b-5p (MIRT036801), hsa-mir-16-5p (MIRT031678), hsa-mir-34a-5p (MIRT025462)

    Block miRNA regulation of human, mouse, rat STRAP using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate STRAP:
    hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidSTRAP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STRAP
    Predesigned siRNA for gene silencing in human, mouse, rat STRAP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STRAP

    Clone
    Products:
         
    OriGene clones in human, mouse for STRAP (see all 6)
    OriGene ORF clones in mouse, rat for STRAP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STRAP (NM_007178)
    Sino Biological Human cDNA Clone for STRAP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRAP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STRAP
    Browse ESI BIO Cell Lines and PureStem Progenitors for STRAP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRAP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STRAP_HUMAN, Q9Y3F4: Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the
    nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion4
    plasma membrane4
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex ----
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with STRAP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STRAP About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Loss of Function of SMAD2/3 in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    2TGF-beta receptor signaling activates SMADs
    Downregulation of TGF-beta receptor signaling0.82
    TGF-beta receptor signaling activates SMADs0.82
    3Signaling by GPCR
    Signal Transduction0.58
    4TGF-beta Receptor Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    5TGF-beta receptor signaling
    TGF-beta receptor signaling


    Find genes that share SuperPaths with STRAP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for STRAP
        TGF-beta Receptor Signaling Pathway
    TGF-beta receptor signaling


    1 Reactome Pathway for STRAP
        Downregulation of TGF-beta receptor signaling


    1 Kegg Pathway  (Kegg details for STRAP):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STRAP
    Interactions:

        GeneGlobe Interaction Network for STRAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STRAP (Q9Y3F41, 2, 3 ENSP000003922704) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C6orf203Q9P0P82, 3, ENSP000003109514MINT-65850 I2D: score=4 STRING: ENSP00000310951
    NME1P155311, 3, ENSP000000130344EBI-727414,EBI-741141 I2D: score=2 STRING: ENSP00000013034
    SNRPD2P623162, 3, ENSP000003423744MINT-58577 I2D: score=2 STRING: ENSP00000342374
    SNRPEP623042, 3, ENSP000004005914MINT-58579 I2D: score=2 STRING: ENSP00000400591
    CHEK2O960172, 3, ENSP000003720234MINT-6806274 I2D: score=1 STRING: ENSP00000372023
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0000387spliceosomal snRNP assembly IDA18984161
    GO:0006397mRNA processing ----
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0008380RNA splicing ----

    Find genes that share ontologies with STRAP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STRAP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STRAP gene: 
    NM_007178.3  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541731 ENST00000025399 ENST00000419869(uc001rdc.4 uc010shw.2 uc001rdd.4)
    ENST00000536737 ENST00000538718 ENST00000539887 ENST00000538352
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STRAP using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate STRAP:
    hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidSTRAP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STRAP
    Predesigned siRNA for gene silencing in human, mouse, rat STRAP
    Clone
    Products:
         
    OriGene clones in human, mouse for STRAP (see all 6)
    OriGene ORF clones in mouse, rat for STRAP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STRAP (NM_007178)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRAP
    Primer
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    OriGene qPCR primer pairs and template standards for STRAP
    OriGene qSTAR qPCR primer pairs in human, mouse for STRAP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STRAP
      QuantiTect SYBR Green Assays in human, mouse, rat STRAP
      QuantiFast Probe-based Assays in human, mouse, rat STRAP

    Selected AceView cDNA sequences (see all 839):

    AA847813 AI090177 BE018364 BP375769 CR593028 BE276863 AU118889 AA458854 
    BU192785 BM785893 BU150576 CR622806 AA481155 AI283939 CR605637 AI628519 
    AW615774 AL711067 CR614164 CR618413 AW130626 AU106793 BQ930095 BU527609 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for STRAP    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c
    SP1:                                                                                          
    SP2:                                                                                          
    SP3:        -                                                                                 
    SP4:                                                                    -                     


    ECgene alternative splicing isoforms for STRAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STRAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAAGTAAC
    STRAP Expression
    About this image


    STRAP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    STRAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STRAP Protein Expression
        Custom PCR Arrays for STRAP
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for STRAP
    OriGene qSTAR qPCR primer pairs in human, mouse for STRAP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STRAP
    QuantiTect SYBR Green Assays in human, mouse, rat STRAP
    QuantiFast Probe-based Assays in human, mouse, rat STRAP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STRAP gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Strap1 , 5 serine/threonine kinase receptor associated protein1, 5 90.57(n)1
    97.71(a)1
      6 (67.27 cM)5
    209011  NM_011499.31  NP_035629.21 
     1377350785 
    chicken
    (Gallus gallus)
    Aves STRAP1 serine/threonine kinase receptor associated protein 79.14(n)
    87.14(a)
      418175  NM_001006247.2  NP_001006247.2 
    lizard
    (Anolis carolinensis)
    Reptilia STRAP6
    serine/threonine kinase receptor associated protei...
    86(a)
    1 ↔ 1
    GL343336.1(852298-866952)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia strap1 serine/threonine kinase receptor associated protein 74.95(n)
    83.74(a)
      100145616  NM_001127023.1  NP_001120495.1 
    zebrafish
    (Danio rerio)
    Actinopterygii strap1 serine/threonine kinase receptor associated protein 74.1(n)
    84.08(a)
      393274  NM_200304.1  NP_956598.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wmd1 wing morphogenesis defect 56.57(n)
    60.88(a)
      37727  NM_137960.2  NP_611804.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIF346
    eIF3i subunit of the core complex of translation i...
    24(a)
    1 → many
    XIII(557481-558524) YMR146C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G154701 AT1G15470 55.36(n)
    50.87(a)
      838117  NM_101416.2  NP_563978.1 


    ENSEMBL Gene Tree for STRAP (if available)
    TreeFam Gene Tree for STRAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STRAP gene
    EIF3I2  
    4 SIMAP similar genes for STRAP using alignment to 5 protein entries:     STRAP_HUMAN (see all proteins):
    WDR61    KATNB1    PF20    POC1B

    Find genes that share paralogs with STRAP           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for STRAP
    PGOHUM00000240621


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STRAP (see all 487)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1166969691,2
    F--15902264(+) GTTACC/GTGAAC 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs79564611,2
    C,F,A,H--15902383(+) TCTATG/CAGGTT 1 -- us2k1 tfbs312Minor allele frequency- C:0.15NS EA NA WA CSA 1089
    rs1474093851,2
    C--15902518(+) TATCA-/ATTAC 
            
    ATTAA
    1 -- us2k10--------
    rs79574271,2
    C,F,A,H--15902564(+) CCTACC/ACAATT 1 -- us2k18Minor allele frequency- A:0.11NS EA WA CSA 661
    rs775663751,2
    C,F--15902708(+) TATCAG/ATATCT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs71359061,2
    C,F,A,H--15902719(+) GACCAC/GTTGTG 1 -- us2k112Minor allele frequency- G:0.34NS EA NA WA 786
    rs1847981081,2
    --15902775(+) ATCTAC/TTTAAT 1 -- us2k10--------
    rs1897004221,2
    --15902790(+) AAACAC/GTCATG 1 -- us2k10--------
    rs733195011,2
    C,F--15902822(+) TTCACT/CTTTCT 1 -- us2k12Minor allele frequency- C:0.04WA 120
    rs1122960411,2
    F--15902848(+) ATGACC/AAAGCC 1 -- us2k11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for STRAP (16035288 - 16056412 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for STRAP: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STRAP
    DNA2.0 Custom Variant and Variant Library Synthesis for STRAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605986    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for STRAP:
    Muscular atrophy     Spinal muscular atrophy

    Find genes that share disorders with STRAP           About GenesLikeMe

    3 Novoseek inferred disease relationships for STRAP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 22.9 2 17316412 (1), 17108118 (1)
    tumors 0 2 17314099 (1), 17916563 (1)
    cancer 0 3 17309779 (1), 17108118 (1)


    Export disorders for STRAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STRAP gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with STRAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization. (PubMed id 16159890)1, 2, 9 Grimmler M.... Fischer U. (Hum. Mol. Genet. 2005)
    2. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. (PubMed id 18984161)1, 2 Chari A....Fischer U. (Cell 2008)
    3. Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine- threonine kinase receptor-associated protein. (PubMed id 16251192)1, 2 Seong H.A.... Ha H. (J. Biol. Chem. 2005)
    4. Unrip is a component of SMN complexes active in snRNP assembly. (PubMed id 15848170)1, 2 Carissimi C.... Pellizzoni L. (FEBS Lett. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    7. Molecular cloning and characterization of human MAWD, a novel protein containing WD-40 repeats frequently overexpressed in breast cancer. (PubMed id 10646843)1, 2 Matsuda S.... Hamaguchi M. (Cancer Res. 2000)
    8. unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA. (PubMed id 10049359)1, 2 Hunt S.L.... Jackson R.J. (Genes Dev. 1999)
    9. Serine-threonine kinase receptor-associated protein inhibits apoptosis signal-regulating kinase 1 function through direct interaction. (PubMed id 19880523)1, 9 Jung H....Ha H. (J. Biol. Chem. 2010)
    10. NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function. (PubMed id 17916563)1, 9 Jung H....Ha H. (J. Biol. Chem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11171 HGNC: 30796 AceView: STRAP Ensembl:ENSG00000023734 euGenes: HUgn11171
    ECgene: STRAP Kegg: 11171 H-InvDB: STRAP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STRAP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STRAP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STRAP gene:
    Search GeneIP for patents involving STRAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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