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Aliases for STRAP Gene

Aliases for STRAP Gene

  • Serine/Threonine Kinase Receptor Associated Protein 2 3 5
  • Unr-Interacting Protein 2 3 4
  • MAP Activator With WD Repeats 3 4
  • WD-40 Repeat Protein PT-WD 3 4
  • UNRIP 3 4
  • MAWD 3 4
  • Serine-Threonine Kinase Receptor-Associated Protein 3
  • PT-WD 3

External Ids for STRAP Gene

Previous GeneCards Identifiers for STRAP Gene

  • GC12P015927
  • GC12P015928
  • GC12P016035
  • GC12P015804

Summaries for STRAP Gene

GeneCards Summary for STRAP Gene

STRAP (Serine/Threonine Kinase Receptor Associated Protein) is a Protein Coding gene. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and TGF-beta receptor signaling activates SMADs. GO annotations related to this gene include poly(A) RNA binding and kinase activity. An important paralog of this gene is EIF3I.

UniProtKB/Swiss-Prot for STRAP Gene

  • The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.

Gene Wiki entry for STRAP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRAP Gene

Genomics for STRAP Gene

Regulatory Elements for STRAP Gene

Enhancers for STRAP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G015881 1.1 ENCODE 8 +0.4 415 3.2 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 STRAP GC12M015893
GH12G015771 0.7 ENCODE dbSUPER 11.2 -111.6 -111633 0.1 ZBTB40 NFE2L2 EPS8 STRAP RNU6-251P ENSG00000255565 GC12M015672
GH12G015698 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.5 -181.5 -181479 5.3 HDGF FOXA2 RAD21 GATA2 ZNF366 RELB FOS ETV6 IKZF2 CREM EPS8 RNU6-251P STRAP ENSG00000256564 GC12M015672 ENSG00000255565
GH12G015725 1.2 Ensembl ENCODE dbSUPER 6.1 -156.1 -156083 1.9 PKNOX1 ZNF362 MTA2 ZNF10 GFI1B ZBTB40 EP300 YY1 FOXA1 PRDM6 RNU6-251P EPS8 STRAP ENSG00000255565 GC12M015672
GH12G015855 1 Ensembl ENCODE 7.1 -26.2 -26185 1.1 CTCF TAF1 MAX ZNF384 RAD21 YY1 RELA ZNF664 ZNF143 HNF4G EPS8 RNU6-251P STRAP ENSG00000256953
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STRAP on UCSC Golden Path with GeneCards custom track

Promoters for STRAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000049300 247 2400 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143

Genomic Location for STRAP Gene

Chromosome:
12
Start:
15,882,354 bp from pter
End:
15,903,478 bp from pter
Size:
21,125 bases
Orientation:
Plus strand

Genomic View for STRAP Gene

Genes around STRAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRAP Gene

Proteins for STRAP Gene

  • Protein details for STRAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3F4-STRAP_HUMAN
    Recommended name:
    Serine-threonine kinase receptor-associated protein
    Protein Accession:
    Q9Y3F4
    Secondary Accessions:
    • B2R5S5
    • B4DNJ6
    • Q5TZT4
    • Q9NTK0
    • Q9UQC8

    Protein attributes for STRAP Gene

    Size:
    350 amino acids
    Molecular mass:
    38438 Da
    Quaternary structure:
    • Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with GEMIN6 and GEMIN7. Associates with the SMN complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1.

    Alternative splice isoforms for STRAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRAP Gene

Post-translational modifications for STRAP Gene

  • Ubiquitination at isoforms=259, isoforms=2156, and Lys298
  • Modification sites at PhosphoSitePlus

Other Protein References for STRAP Gene

No data available for DME Specific Peptides for STRAP Gene

Domains & Families for STRAP Gene

Gene Families for STRAP Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y3F4

UniProtKB/Swiss-Prot:

STRAP_HUMAN :
  • Belongs to the WD repeat STRAP family.
Family:
  • Belongs to the WD repeat STRAP family.
genes like me logo Genes that share domains with STRAP: view

Function for STRAP Gene

Molecular function for STRAP Gene

UniProtKB/Swiss-Prot Function:
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.

Gene Ontology (GO) - Molecular Function for STRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 17314099
genes like me logo Genes that share ontologies with STRAP: view
genes like me logo Genes that share phenotypes with STRAP: view

Animal Model Products

CRISPR Products

miRNA for STRAP Gene

miRTarBase miRNAs that target STRAP

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STRAP Gene

Localization for STRAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRAP Gene

Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STRAP gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
mitochondrion 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 17929853
GO:0005829 cytosol TAS --
GO:0032797 SMN complex IDA 18984161
genes like me logo Genes that share ontologies with STRAP: view

Pathways & Interactions for STRAP Gene

genes like me logo Genes that share pathways with STRAP: view

Pathways by source for STRAP Gene

SIGNOR curated interactions for STRAP Gene

Is activated by:

Gene Ontology (GO) - Biological Process for STRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0000387 spliceosomal snRNP assembly IDA 18984161
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0010633 negative regulation of epithelial cell migration IMP 23687415
genes like me logo Genes that share ontologies with STRAP: view

Drugs & Compounds for STRAP Gene

No Compound Related Data Available

Transcripts for STRAP Gene

Unigene Clusters for STRAP Gene

Serine/threonine kinase receptor associated protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRAP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1:
SP2:
SP3: -
SP4: -

Relevant External Links for STRAP Gene

GeneLoc Exon Structure for
STRAP
ECgene alternative splicing isoforms for
STRAP

Expression for STRAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STRAP Gene

Protein differential expression in normal tissues from HIPED for STRAP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.4) and Bone (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STRAP Gene



Protein tissue co-expression partners for STRAP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STRAP Gene:

STRAP

SOURCE GeneReport for Unigene cluster for STRAP Gene:

Hs.743971

Evidence on tissue expression from TISSUES for STRAP Gene

  • Nervous system(5)
  • Eye(4.6)
  • Liver(4.5)
  • Blood(4.3)
  • Lung(3.9)
  • Intestine(3.5)
  • Kidney(3.4)
  • Skin(3.2)
  • Pancreas(3.1)
  • Heart(2.4)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with STRAP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STRAP Gene

Orthologs for STRAP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STRAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRAP 34 35
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia STRAP 34 35
  • 95.05 (n)
cow
(Bos Taurus)
Mammalia STRAP 34 35
  • 94.1 (n)
oppossum
(Monodelphis domestica)
Mammalia STRAP 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Strap 34 16 35
  • 90.57 (n)
rat
(Rattus norvegicus)
Mammalia Strap 34
  • 90 (n)
chicken
(Gallus gallus)
Aves STRAP 34 35
  • 79.14 (n)
lizard
(Anolis carolinensis)
Reptilia STRAP 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia strap 34
  • 74.95 (n)
zebrafish
(Danio rerio)
Actinopterygii strap 34 35
  • 74.1 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005029 34
  • 56.6 (n)
fruit fly
(Drosophila melanogaster)
Insecta wmd 35 34
  • 56.57 (n)
OneToMany
CG10459 35
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF34 35
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G15470 34
  • 55.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4206 35
  • 57 (a)
OneToOne
Species where no ortholog for STRAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STRAP Gene

ENSEMBL:
Gene Tree for STRAP (if available)
TreeFam:
Gene Tree for STRAP (if available)

Paralogs for STRAP Gene

Paralogs for STRAP Gene

(4) SIMAP similar genes for STRAP Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for STRAP Gene

genes like me logo Genes that share paralogs with STRAP: view

Variants for STRAP Gene

Sequence variations from dbSNP and Humsavar for STRAP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000018911 -- 15,882,158(+) ACTCG(A/G)CCGCG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000082506 -- 15,881,985(+) AAGAC(A/G)AATTG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000121931 -- 15,902,824(+) TTTTC(A/G)TTCCT intron-variant
rs1000125332 -- 15,888,169(+) GAAAA(A/G)ATAGC intron-variant
rs1000169718 -- 15,900,310(+) GCGGA(A/T)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STRAP Gene

Variant ID Type Subtype PubMed ID
esv2760899 CNV gain 21179565

Variation tolerance for STRAP Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STRAP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STRAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRAP Gene

Disorders for STRAP Gene

Relevant External Links for STRAP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STRAP

No disorders were found for STRAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STRAP Gene

Publications for STRAP Gene

  1. Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization. (PMID: 16159890) Grimmler M. … Fischer U. (Hum. Mol. Genet. 2005) 3 4 22 64
  2. Serine-threonine kinase receptor-associated protein inhibits apoptosis signal-regulating kinase 1 function through direct interaction. (PMID: 19880523) Jung H. … Ha H. (J. Biol. Chem. 2010) 3 22 64
  3. MMP28 gene expression is regulated by Sp1 transcription factor acetylation. (PMID: 20144149) Swingler T.E. … Clark I.M. (Biochem. J. 2010) 3 22 64
  4. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. (PMID: 18984161) Chari A. … Fischer U. (Cell 2008) 3 4 64
  5. NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling. (PMID: 17314099) Seong H.A. … Ha H. (J. Biol. Chem. 2007) 3 22 64

Products for STRAP Gene

Sources for STRAP Gene

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