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Aliases for STRADB Gene

Aliases for STRADB Gene

  • STE20-Related Kinase Adaptor Beta 2 3
  • ALS2CR2 3 4 6
  • ILPIP 3 4 6
  • Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein 3 4
  • Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 2 2 3
  • Pseudokinase ALS2CR2 3 4
  • STRAD Beta 3 4
  • CALS-21 3 4
  • STE20-Related Kinase Adapter Protein Beta 3
  • ILP-Interacting Protein ILPIPA 3
  • ILP-Interacting Protein 4
  • PRO1038 3
  • ILPIPA 3
  • PAPK 3

External Ids for STRADB Gene

Previous HGNC Symbols for STRADB Gene

  • ALS2CR2

Previous GeneCards Identifiers for STRADB Gene

  • GC02P202025
  • GC02P202252
  • GC02P194164

Summaries for STRADB Gene

Entrez Gene Summary for STRADB Gene

  • This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for STRADB Gene

STRADB (STE20-Related Kinase Adaptor Beta) is a Protein Coding gene. Diseases associated with STRADB include lateral sclerosis. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include protein kinase activity. An important paralog of this gene is OXSR1.

UniProtKB/Swiss-Prot for STRADB Gene

  • Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).

Gene Wiki entry for STRADB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRADB Gene

Genomics for STRADB Gene

Regulatory Elements for STRADB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STRADB Gene

Start:
201,387,858 bp from pter
End:
201,480,851 bp from pter
Size:
92,994 bases
Orientation:
Plus strand

Genomic View for STRADB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STRADB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRADB Gene

Proteins for STRADB Gene

  • Protein details for STRADB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0K7-STRAB_HUMAN
    Recommended name:
    STE20-related kinase adapter protein beta
    Protein Accession:
    Q9C0K7
    Secondary Accessions:
    • Q5BKY7
    • Q9P1L0

    Protein attributes for STRADB Gene

    Size:
    418 amino acids
    Molecular mass:
    47026 Da
    Quaternary structure:
    • Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Interacts with BIRC4/XIAP. These two proteins are likely to coexist in a complex with TAK1, TRAF6, TAB1 and TAB2.

    Alternative splice isoforms for STRADB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRADB Gene

Proteomics data for STRADB Gene at MOPED

Post-translational modifications for STRADB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STRADB Gene

Antibody Products

No data available for DME Specific Peptides for STRADB Gene

Domains for STRADB Gene

Gene Families for STRADB Gene

Protein Domains for STRADB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STRADB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0K7

UniProtKB/Swiss-Prot:

STRAB_HUMAN :
  • Q9C0K7
Domain:
  • The protein kinase domain is predicted to be catalytically inactive
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STRADB: view

Function for STRADB Gene

Molecular function for STRADB Gene

UniProtKB/Swiss-Prot Function: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).

Gene Ontology (GO) - Molecular Function for STRADB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 NOT protein kinase activity IDA 14517248
GO:0004702 NOT receptor signaling protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 14676191
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with STRADB: view

Phenotypes for STRADB Gene

genes like me logo Genes that share phenotypes with STRADB: view

Animal Model Products

CRISPR Products

miRNA for STRADB Gene

miRTarBase miRNAs that target STRADB

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for STRADB Gene

Localization for STRADB Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRADB Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STRADB Gene COMPARTMENTS Subcellular localization image for STRADB gene
Compartment Confidence
nucleus 5
cytosol 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for STRADB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14517248
GO:0005737 cytoplasm IDA 14517248
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STRADB: view

Pathways for STRADB Gene

genes like me logo Genes that share pathways with STRADB: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for STRADB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 NOT mitotic cell cycle IBA --
GO:0000902 cell morphogenesis IEA --
GO:0006468 NOT protein phosphorylation IDA 14517248
GO:0006611 protein export from nucleus IDA 14517248
GO:0007050 cell cycle arrest TAS --
genes like me logo Genes that share ontologies with STRADB: view

Transcripts for STRADB Gene

Unigene Clusters for STRADB Gene

STE20-related kinase adaptor beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STRADB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRADB Gene

No ASD Table

Relevant External Links for STRADB Gene

GeneLoc Exon Structure for
STRADB
ECgene alternative splicing isoforms for
STRADB

Expression for STRADB Gene

mRNA expression in normal human tissues for STRADB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STRADB Gene

This gene is overexpressed in Whole Blood (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for STRADB Gene

SOURCE GeneReport for Unigene cluster for STRADB Gene Hs.652338

mRNA Expression by UniProt/SwissProt for STRADB Gene

Q9C0K7-STRAB_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, testis, liver and colon.
genes like me logo Genes that share expressions with STRADB: view

In Situ Assay Products

Orthologs for STRADB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRADB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRADB 35
  • 99.6 (n)
  • 99.76 (a)
cow
(Bos Taurus)
Mammalia STRADB 35
  • 93.22 (n)
  • 94.26 (a)
STRADB 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STRADB 35
  • 93.24 (n)
  • 93.96 (a)
STRADB 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stradb 35
  • 89.71 (n)
  • 90.91 (a)
Stradb 16
Stradb 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STRADB 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRADB 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stradb 35
  • 89 (n)
  • 89.71 (a)
chicken
(Gallus gallus)
Aves STRADB 35
  • 73.38 (n)
  • 71.84 (a)
STRADB 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRADB 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stradb 35
  • 67.28 (n)
  • 62.47 (a)
zebrafish
(Danio rerio)
Actinopterygii STRADB 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Stlk 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea strd-1 36
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLA4 36
  • 10 (a)
ManyToMany
SKM1 36
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for STRADB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRADB Gene

ENSEMBL:
Gene Tree for STRADB (if available)
TreeFam:
Gene Tree for STRADB (if available)

Paralogs for STRADB Gene

Paralogs for STRADB Gene

Selected SIMAP similar genes for STRADB Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for STRADB Gene

genes like me logo Genes that share paralogs with STRADB: view

Variants for STRADB Gene

Sequence variations from dbSNP and Humsavar for STRADB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1009276 -- 201,458,233(-) TCTGC(A/G)TATTA intron-variant
rs1019299 -- 201,473,007(+) CCCAC(A/G)GGAAC reference, synonymous-codon, utr-variant-5-prime
rs2023501 -- 201,469,280(-) TGATA(A/G)CCATG intron-variant
rs2080327 -- 201,461,495(-) ATAAA(C/T)ATTTC intron-variant
rs2110748 -- 201,480,753(-) CCCTT(G/T)TTTAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for STRADB Gene

Variant ID Type Subtype PubMed ID
nsv3111 CNV Insertion 18451855

Relevant External Links for STRADB Gene

HapMap Linkage Disequilibrium report
STRADB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRADB Gene

Disorders for STRADB Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for STRADB Gene including...

Search for STRADB Gene in MalaCards »
genes like me logo Genes that share disorders with STRADB: view

No data available for UniProtKB/Swiss-Prot for STRADB Gene

Publications for STRADB Gene

  1. Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. (PMID: 11161814) Hadano S. … Hayden M.R. (Genomics 2001) 2 3 4
  2. ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. (PMID: 12048196) Sanna M.G. … Ulevitch R.J. (J. Biol. Chem. 2002) 3 4
  3. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. (PMID: 14511394) Hawley S.A. … Hardie D.G. (J. Biol. 2003) 2 3
  4. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. (PMID: 14517248) Boudeau J. … Alessi D.R. (EMBO J. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for STRADB Gene

Sources for STRADB Gene

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