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STRADB Gene

protein-coding   GIFtS: 53
GCID: GC02P202252

STE20-Related Kinase Adaptor Beta

(Previous names: amyotrophic lateral sclerosis 2 (juvenile) chromosome region,...)
(Previous symbol: ALS2CR2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
STE20-Related Kinase Adaptor Beta1 2     STRAD Beta2 3
ALS2CR21 2 3 5     ILPIPA2
ILPIP2 3 5     PAPK2
Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 21 2     ILP-Interacting Protein ILPIPA2
Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2
Protein2 3
     STE20-Related Kinase Adapter Protein Beta2
Pseudokinase ALS2CR22 3     ILP-Interacting Protein3
CALS-212 3     

External Ids:    HGNC: 132051   Entrez Gene: 554372   Ensembl: ENSG000000821467   OMIM: 6073335   UniProtKB: Q9C0K73   

Export aliases for STRADB gene to outside databases

Previous GC identifers: GC02P202025 GC02P194164


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STRADB Gene:
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active
site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This
protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase
that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this
kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase.
The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein,
and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction
pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, May 2011)

GeneCards Summary for STRADB Gene:
STRADB (STE20-related kinase adaptor beta) is a protein-coding gene. Diseases associated with STRADB include amyotrophic lateral sclerosis 2, juvenile, and lateral sclerosis. GO annotations related to this gene include protein kinase activity. An important paralog of this gene is OXSR1.

UniProtKB/Swiss-Prot: STRAB_HUMAN, Q9C0K7
Function: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and
activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a
pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity)

Gene Wiki entry for STRADB (ALS2CR2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STRADB gene promoter:
         LHX3b/Lhx3b   POU2F1   POU2F1a   Bach2   FOXO4   LHX3a/Lhx3a   CUTL1   LyF-1   ITF-2   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTRADB promoter sequence
   Search Chromatin IP Primers for STRADB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STRADB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.1

STRADB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STRADB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P202252:  view genomic region     (about GC identifiers)

Start:
202,252,581 bp from pter      End:
202,345,574 bp from pter
Size:
92,994 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: STRAB_HUMAN, Q9C0K7 (See protein sequence)
Recommended Name: STE20-related kinase adapter protein beta  
Size: 418 amino acids; 47026 Da
Subunit: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25
(CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its
catalytic activity. Interacts with BIRC4/XIAP. These two proteins are likely to coexist in a complex with TAK1,
TRAF6, TAB1 and TAB2
Caution: Ser-184 is present instead of the conserved Asp which is expected to be an active site residue
Secondary accessions: Q5BKY7 Q9P1L0
Alternative splicing: 3 isoforms:  Q9C0K7-1   Q9C0K7-2   Q9C0K7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STRADB: NX_Q9C0K7

Explore proteomics data for STRADB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STRADB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001193793.1  NP_061041.2  

    ENSEMBL proteins: 
     ENSP00000409552   ENSP00000194530   ENSP00000404359   ENSP00000376080   ENSP00000413574  
    Reactome Protein details: Q9C0K7

    STRADB Human Recombinant Protein Products:

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    Novus Biologicals STRADB Proteins
    Novus Biologicals STRADB Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: STE20-related kinase adaptor beta
    STLK subfamily

    2 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9C0K7

    ProtoNet protein and cluster: Q9C0K7

    UniProtKB/Swiss-Prot: STRAB_HUMAN, Q9C0K7
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    STRADB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STRAB_HUMAN, Q9C0K7
    Function: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and
    activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a
    pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672NOT protein kinase activity IDA14517248
    GO:0004702NOT receptor signaling protein serine/threonine kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI14676191
    GO:0005524ATP binding IEA--
         
    STRADB for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for STRADB:
     Synthetic lethal with c-Myc af  Weaker migration 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STRADB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STRADB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STRADB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STRADB

    miRNA
    Products:
        
    miRTarBase miRNAs that target STRADB:
    hsa-mir-26a-5p (MIRT004339), hsa-mir-24-3p (MIRT030416), hsa-mir-193b-3p (MIRT016295)

    Block miRNA regulation of human, mouse, rat STRADB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STRADB (see all 18):
    hsa-miR-140-5p hsa-miR-498 hsa-miR-148b hsa-miR-15a hsa-miR-1297 hsa-miR-424 hsa-miR-15b* hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidSTRADB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STRADB
    Predesigned siRNA for gene silencing in human, mouse, rat STRADB

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for STRADB

    Clone
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    OriGene clones in human, mouse for STRADB (see all 6)
    OriGene ORF clones in mouse, rat for STRADB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): STRADB (NM_018571)
    Sino Biological Human cDNA Clone for STRADB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRADB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRADB

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRADB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STRAB_HUMAN, Q9C0K7: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA14517248
    GO:0005737cytoplasm IDA14517248
    GO:0005829cytosol TAS--

    STRADB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STRADB About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    PI3K Cascade0.87
    IRS-related events0.94
    Signaling by Insulin receptor0.80
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    PKB-mediated events0.41
    IRS-mediated signalling0.92
    mTOR signalling0.39
    2Signaling by GPCR
    Signal Transduction0.58
    3LKB1 signaling events
    LKB1 signaling events
    4AMPK signaling
    AMPK signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for STRADB
        AMPK signaling
    LKB1 signaling events


    1 Reactome Pathway for STRADB
        Regulation of AMPK activity via LKB1



    STRADB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including STRADB: 
              mTOR Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for STRADB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STRADB (Q9C0K71, 2, 3 ENSP000001945304) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK11Q158311, 3, ENSP000003248564EBI-306893,EBI-306838 I2D: score=5 STRING: ENSP00000324856
    CAB39Q9Y3761, 3, ENSP000002584184EBI-306893,EBI-306905 I2D: score=2 STRING: ENSP00000258418
    MAP3K7O433183, ENSP000003583354I2D: score=3 STRING: ENSP00000358335
    XIAPP981703, ENSP000003478584I2D: score=3 STRING: ENSP00000347858
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis IEA--
    GO:0006468NOT protein phosphorylation IDA14517248
    GO:0006611protein export from nucleus IDA14517248
    GO:0007050cell cycle arrest TAS--
    GO:0007254JNK cascade IEA--

    STRADB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STRADB (STRAB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STRADB gene (2 alternative transcripts): 
    NM_001206864.1  NM_018571.5  

    Unigene Cluster for STRADB:

    STE20-related kinase adaptor beta
    Hs.652338  [show with all ESTs]
    Unigene Representative Sequence: NM_001206864
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000458269 ENST00000194530(uc021vvb.1 uc002uyd.4) ENST00000488196
    ENST00000447698 ENST00000392249 ENST00000484098 ENST00000498648 ENST00000468123
    ENST00000415688 ENST00000466770
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STRADB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STRADB (see all 18):
    hsa-miR-140-5p hsa-miR-498 hsa-miR-148b hsa-miR-15a hsa-miR-1297 hsa-miR-424 hsa-miR-15b* hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidSTRADB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STRADB
    Predesigned siRNA for gene silencing in human, mouse, rat STRADB
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): STRADB (NM_018571)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRADB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRADB
    Primer
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    OriGene qPCR primer pairs and template standards for STRADB
    OriGene qSTAR qPCR primer pairs in human, mouse for STRADB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STRADB
      QuantiTect SYBR Green Assays in human, mouse, rat STRADB
      QuantiFast Probe-based Assays in human, mouse, rat STRADB

    Additional mRNA sequence: 

    AB038950.1 AK024720.1 AK027637.1 AK290457.1 AY093697.1 BC008302.1 BC090871.1 

    17 DOTS entries:

    DT.100816727  DT.95096921  DT.120970385  DT.120970419  DT.415958  DT.100816726  DT.121412629  DT.92431355 
    DT.92431361  DT.100663057  DT.120970449  DT.120970334  DT.120970380  DT.120970434  DT.430895  DT.95096922 
    DT.86859036 

    Selected AceView cDNA sequences (see all 143):

    BQ676362 BG941123 CB148941 AA371276 AA843432 BM682304 NM_018571 BX089880 
    AK027637 BQ440949 BM993954 BE218019 H98822 BQ680065 AA294905 BC008302 
    AL599064 BQ648474 BU685878 AA455287 R43945 AI360412 BQ647804 N31310 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STRADB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCTTCAA
    STRADB Expression
    About this image


    STRADB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Brain (Nervous System)
             Cerebral Cortex
    STRADB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STRADB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.652338

    UniProtKB/Swiss-Prot: STRAB_HUMAN, Q9C0K7
    Tissue specificity: Highly expressed in heart, skeletal muscle, testis, liver and colon

        Pathway & Disease-focused RT2 Profiler PCR Array including STRADB: 
              mTOR Signaling in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for STRADB
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    QuantiFast Probe-based Assays in human, mouse, rat STRADB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRADB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for STRADB gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stradb1 , 5 STE20-related kinase adaptor beta1, 5 89.71(n)1
    90.91(a)1
      1 (29.20 cM)5
    2271541  NM_172656.51  NP_766244.41 
     589735225 
    chicken
    (Gallus gallus)
    Aves STRADB1 STE20-related kinase adaptor beta 73.38(n)
    71.84(a)
      424083  XM_004942611.1  XP_004942668.1 
    lizard
    (Anolis carolinensis)
    Reptilia STRADB6
    STE20-related kinase adaptor beta
    64(a)
    1 ↔ 1
    GL343478.1(254311-285098)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia stradb1 STE20-related kinase adaptor beta 67.28(n)
    62.47(a)
      100495317  XM_002936539.2  XP_002936585.2 
    zebrafish
    (Danio rerio)
    Actinopterygii STRADB6
    STE20-related kinase adaptor beta
    52(a)
    1 ↔ 1
    6(4109491-4118565) ENSDARG00000088225
    fruit fly
    (Drosophila melanogaster)
    Insecta Stlk6
    Ste20-like kinase
    29(a)
    1 → many
    2R(434181-452786)
    worm
    (Caenorhabditis elegans)
    Secernentea strd-16
    Protein STRD-1, isoform a (strd-1) mRNA, complete ...
    25(a)
    1 → many
    III(10947446-10951169) WBGene00013132
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SKM16
    CLA46
    Member of the PAK family of serine/threonine prote...
    Cdc42p-activated signal transducing kinase of the ...
    13(a)
    10(a)
    many ↔ many
    many ↔ many
    XV(104326-106293) YOL113W
    XIV(68915-71443) YNL298W


    ENSEMBL Gene Tree for STRADB (if available)
    TreeFam Gene Tree for STRADB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STRADB gene
    OXSR12  STRADA2  STK392  
    3 SIMAP similar genes for STRADB using alignment to 4 protein entries:     STRAB_HUMAN (see all proteins):
    STRADA    STK25    MAP4K5

    STRADB for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STRADB
    PGOHUM00000260293


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STRADB (see all 499)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0413354
    A metastatic melanoma sample4--see VAR_0413352 G E mis40--------
    rs1399000781,2
    Cuntested1201733914(+) ATGTGA/GTTTTC 3 D G mis1 ut310--------
    rs1931547501,2
    --201703566(+) AGGCGC/TGTGCC 2 -- us2k10--------
    rs1446742791,2
    C--201703752(+) AGTGAA/GCCACA 2 -- us2k10--------
    rs1478828711,2
    --201703765(+) GCCCGA/GCCAAA 2 -- us2k10--------
    rs1489206701,2
    --201703838(+) TGTCTC/TTCACA 2 -- us2k10--------
    rs621892541,2
    C--201703885(+) CATTAC/TTTAAT 2 -- us2k16Minor allele frequency- T:0.40NA WA EA 364
    rs748452301,2
    C--201704009(+) ACATGG/TTGAAA 2 -- us2k10--------
    rs1899032491,2
    --201704093(+) GCTGAA/GGCAGG 2 -- us2k10--------
    rs67176411,2
    C,F,A,H--201704259(+) TTTCTC/TACCTC 2 -- us2k1 tfbs321Minor allele frequency- T:0.47NS EA NA WA CSA 2515

    HapMap Linkage Disequilibrium report for STRADB (202252581 - 202345574 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for STRADB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3111CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STRADB
    DNA2.0 Custom Variant and Variant Library Synthesis for STRADB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607333    OMIM disorders: --

    7 diseases for STRADB:    
    About MalaCards
    amyotrophic lateral sclerosis 2, juvenile    lateral sclerosis    polyploidy    amyotrophic lateral sclerosis
    thyroiditis    cerebritis    endotheliitis


    STRADB for disorders           About GeneDecksing


    Export disorders for STRADB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STRADB gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with STRADB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. (PubMed id 11161814)1, 2, 3 Hadano S.... Hayden M.R. (Genomics 2001)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. (PubMed id 14517248)1, 2 Boudeau J.... Alessi D.R. (EMBO J. 2003)
    6. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. (PubMed id 14511394)1, 3 Hawley S.A....Hardie D.G. (J. Biol. 2003)
    7. ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. (PubMed id 12048196)1, 2 Sanna M.G.... Ulevitch R.J. (J. Biol. Chem. 2002)
    8. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    9. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (Nature 2010)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55437 HGNC: 13205 AceView: ALS2CR2 Ensembl:ENSG00000082146 euGenes: HUgn55437
    ECgene: STRADB H-InvDB: STRADB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STRADB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STRADB gene:
    Search GeneIP for patents involving STRADB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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