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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STRADB Gene

protein-coding   GIFtS: 51
GCID: GC02P202252

STE20-related kinase adaptor beta

(Previous names: amyotrophic lateral sclerosis 2 (juvenile) chromosome region,...)
(Previous symbol: ALS2CR2)
 Explore 4 diseases affiliated with
STRADB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STRADB    

Aliases
for STRADB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
STE20-Related Kinase Adaptor Beta1 2     Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein2 3
ALS2CR21 2 3 5     Pseudokinase ALS2CR22 3
ILPIP1 2 3 5     STRAD Beta2 3
CALS-211 2 3     ILP-Interacting Protein ILPIPA2
ILPIPA1 2     STE20-Related Kinase Adapter Protein Beta2
PAPK1 2     ILP-Interacting Protein3
Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 21 2     

External Ids:    HGNC: 132051   Entrez Gene: 554372   Ensembl: ENSG000000821467   OMIM: 6073335   UniProtKB: Q9C0K73   

Export aliases for STRADB gene to outside databases

Previous GC identifers: GC02P202025 GC02P194164


Summaries
for STRADB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for STRADB:
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site
residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a
component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell
polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to
the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene
can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the
anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on
chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: STRAB_HUMAN, Q9C0K7
Function: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates
STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate,
promoting conformational change of STK11/LKB1 in an active conformation (By similarity)

Gene Wiki entry for STRADB (ALS2CR2)


Genomic Views
for STRADB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STRADB gene promoter:
         LHX3b/Lhx3b   POU2F1   POU2F1a   Bach2   FOXO4   LHX3a/Lhx3a   CUTL1   LyF-1   ITF-2   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STRADB promoter sequence
   Search SABiosciences Chromatin IP Primers for STRADB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STRADB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.1

STRADB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STRADB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P202252:  view genomic region     (about GC identifiers)

Start:
 202,252,581 bp from pter      End:
 202,345,574 bp from pter
Size:
 92,994 bases      Orientation:
 plus strand

Proteins
for STRADB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STRAB_HUMAN, Q9C0K7 (See protein sequence)
Recommended Name: STE20-related kinase adapter protein beta  
Size: 418 amino acids; 47026 Da
Subunit: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25
(CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic
activity. Interacts with BIRC4/XIAP. These two proteins are likely to coexist in a complex with TAK1, TRAF6, TAB1 and
TAB2
Subcellular location: Nucleus. Cytoplasm
Caution: Ser-184 is present instead of the conserved Asp which is expected to be an active site residue
Secondary accessions: Q5BKY7 Q9P1L0
Alternative splicing: 3 isoforms:  Q9C0K7-1   Q9C0K7-2   Q9C0K7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STRADB: NX_Q9C0K7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9C0K7

    • STRADB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001193793.1  NP_061041.2  

    ENSEMBL proteins: 
     ENSP00000409552   ENSP00000194530   ENSP00000404359   ENSP00000376080   ENSP00000413574  
     ENSP00000443981  
    Reactome Protein details: Q9C0K7
    Human Recombinant Protein Products: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: STRADB
    OriGene Custom Protein Services for STRADB 
    GenScript Custom Purified and Recombinant Proteins Services for STRADB
    Novus Biologicals STRADB Proteins
    Novus Biologicals STRADB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA14517248
    GO:0005737cytoplasm IDA14517248
    GO:0005829cytosol TAS--


    STRADB for ontologies           About GeneDecksing



    STRADB Antibody Products: 
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    OriGene Antibodies (see all 2): STRADB
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    Novus Biologicals STRADB Antibodies
    Search for Antibodies for STRADB at Abcam  
    Browse Antibodies at Uscn
    ThermoFisher Antibody for STRADB

    Assay Products for STRADB: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for STRADB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STRADB for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9C0K7

    ProtoNet protein and cluster: Q9C0K7

    UniProtKB/Swiss-Prot: STRAB_HUMAN, Q9C0K7
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for STRADB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STRAB_HUMAN, Q9C0K7
    Function: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates
    STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate,
    promoting conformational change of STK11/LKB1 in an active conformation (By similarity)

    miRNA
    Products:            		miRTarBase miRNAs that target STRADB:
    hsa-mir-26a (MIRT004339)

    OriGene 3'-UTR Clone: STRADB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STRADB
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate STRADB (see all 18):
    hsa-miR-140-5p hsa-miR-498 hsa-miR-148b hsa-miR-15a hsa-miR-1297 hsa-miR-424 hsa-miR-15b* hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmid: STRADB 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STRADB (see all 4)
    OriGene shRNA RFP: STRADB
    OriGene siRNA: STRADB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STRADB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for STRADB

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STRADB (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STRADB
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): STRADB (NM_018571)
    Sino Biological Human cDNA Clone for STRADB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRADB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRADB 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for STRADB
    Search LifeMap BioReagents cell lines for STRADB

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRADB

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672NOT protein kinase activity IDA14517248
    GO:0005515protein binding IPI--
    GO:0005524ATP binding NAS--


    STRADB for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for STRADB:
     Synthetic lethal with c-Myc af  Weaker migration 


    Pathways & Interactions
    for STRADB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1IRS-related events
    		IRS-related events1.00
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		IRS-mediated signalling0.98
    		IGF1R signaling cascade0.90
    		Insulin receptor signalling cascade0.94
    		PI3K Cascade0.84
    		IRS-related events triggered by IGF1R0.93
    		Signaling by Insulin receptor0.74
    2Energy dependent regulation of mTOR by LKB1-AMPK
    		Energy dependent regulation of mTOR by LKB1-AMPK1.00
    		Regulation of AMPK activity via LKB10.82
    3mTOR signalling
    		mTOR signalling1.00
    		PKB-mediated events0.96
    4AMPK signaling
    		AMPK signaling1.00
    5LKB1 signaling events
    		LKB1 signaling events1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for STRADB 
        AMPK signaling
    LKB1 signaling events

    5/13        Reactome Pathways for STRADB (see all 13)
        PI3K Cascade
    Regulation of AMPK activity via LKB1
    IGF1R signaling cascade
    mTOR signalling
    Energy dependent regulation of mTOR by LKB1-AMPK



    STRADB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STRADB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for STRADB (Q9C0K71, 2, 3 ENSP000001945304) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK11Q158311, 3, ENSP000003248564EBI-306893,EBI-306838 I2D: score=5 STRING: ENSP00000324856
    CAB39Q9Y3761, 3, ENSP000002584184EBI-306893,EBI-306905 I2D: score=2 STRING: ENSP00000258418
    MAP3K7O433183, ENSP000003583354I2D: score=3 STRING: ENSP00000358335
    XIAPP981703, ENSP000003478584I2D: score=3 STRING: ENSP00000347858
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis IEA--
    GO:0006468NOT protein phosphorylation IDA14517248
    GO:0006611protein export from nucleus IDA14517248
    GO:0007050cell cycle arrest TAS--
    GO:0007254JNK cascade IEA--


    STRADB for ontologies           About GeneDecksing



    Drugs & Compounds
    for STRADB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STRADB
    Search CenterWatch for drugs/clinical trials and news about STRADB / STRAB 

    Transcripts
    for STRADB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STRADB gene (2 alternative transcripts): 
    NM_001206864.1  NM_018571.5  

    Unigene Cluster for STRADB:

    STE20-related kinase adaptor beta
    Hs.652338  [show with all ESTs]
    Unigene Representative Sequence: NM_001206864
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000458269 ENST00000194530(uc021vvb.1 uc002uyd.4) ENST00000488196
    ENST00000447698 ENST00000392249 ENST00000484098 ENST00000498648 ENST00000468123
    ENST00000415688 ENST00000466770 ENST00000539670

    miRNA
    Products:             		 OriGene 3'-UTR Clone: STRADB
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STRADB
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate STRADB (see all 18):
    hsa-miR-140-5p hsa-miR-498 hsa-miR-148b hsa-miR-15a hsa-miR-1297 hsa-miR-424 hsa-miR-15b* hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmid: STRADB 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STRADB (see all 4)
    OriGene shRNA RFP: STRADB
    OriGene siRNA: STRADB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STRADB
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STRADB (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STRADB
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): STRADB (NM_018571)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRADB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRADB 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STRADB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STRADB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STRADB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STRADB

    Additional cDNA sequence: 

    AB038950.1 AK024720.1 AK027637.1 AK290457.1 AY093697.1 BC008302.1 BC090871.1 

    17 DOTS entries:

    DT.100816727  DT.95096921  DT.120970385  DT.120970419  DT.415958  DT.100816726  DT.121412629  DT.92431355 
    DT.92431361  DT.100663057  DT.120970449  DT.120970334  DT.120970380  DT.120970434  DT.430895  DT.95096922 
    DT.86859036 

    24/143 AceView cDNA sequences (see all 143):

    BQ676362 AL599064 BM993954 BE218019 BQ680065 BX089880 NM_018571 AK027637 
    AA294905 BG941123 AA843432 AA371276 CB148941 BM682304 BC008302 H98822 
    BQ440949 BI517858 BM263589 AL599171 AF116618 BG910321 BG249014 CA426448 

    GeneLoc Exon Structure


    Expression
    for STRADB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STRADB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTCTTCAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See STRADB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STRADB

    SOURCE GeneReport for Unigene cluster: Hs.652338

    UniProtKB/Swiss-Prot: STRAB_HUMAN, Q9C0K7
    Tissue specificity: Highly expressed in heart, skeletal muscle, testis, liver and colon

        SABiosciences Expression via Pathway-Focused PCR Array including STRADB: 
              mTOR Signaling in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STRADB
    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STRADB
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRADB

    Orthologs
    for STRADB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for STRADB gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves STRADB1 STE20-related kinase adaptor beta 73.38(n)
    71.84(a)    		   424083  XM_421938.2  XP_421938.2 
    lizard
    (Anolis carolinensis)    		 Reptilia STRADB6
    		 --
    		 68(a)
    		 1 ↔ 1
    		 GL343478.1(270650-285047)
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01074399.16
    		 --
    		 53(a)
    		 1 ↔ 1
    		 6(4109491-4118565)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Stlk6
    		 Ste20-like kinase
    		 25(a)
    		 1 → many
    		 2R(434181-452786)
    worm
    (Caenorhabditis elegans)    		 Secernentea strd-16
    		 STRAD (yeast STE20 Related Adaptor protein) homolo...
    		 23(a)
    		 1 → many
    		 III(10947343-10951070)


    ENSEMBL Gene Tree for STRADB (if available)
    TreeFam Gene Tree for STRADB (if available) 

    Paralogs
    for STRADB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STRADB gene
    OXSR12  STRADA2  STK392  
    3 SIMAP similar genes for STRADB using alignment to 4 protein entries:     STRAB_HUMAN (see all proteins):
    STRADA    STK25    MAP4K5

    STRADB for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STRADB
    PGOHUM00000260293


    Genomic Variants
    for STRADB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/389 NCBI SNPs in STRADB are shown (see all 389)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1399000781,2
    		Cother202344861(+) ATGTGA/GTTTTC 3 D G ut31 mis10--------
    rs1131049581,2
    		C,--202314410(+) TGTTGC/TCCAGG 3 -- us2k1 int11Minor allele frequency- T:0.50NA 2
    rs1931547501,2
    		--202314514(+) AGGCGC/TGTGCC 3 -- us2k1 int10--------
    rs1446742791,2
    		--202314700(+) AGTGAA/GCCACA 3 -- us2k1 int10--------
    rs1478828711,2
    		--202314713(+) GCCCGA/GCCAAA 3 -- int1 us2k10--------
    rs1489206701,2
    		--202314786(+) TGTCTC/TTCACA 3 -- us2k1 int10--------
    rs621892541,2
    		C,--202314833(+) CATTAC/TTTAAT 3 -- us2k1 int16Minor allele frequency- T:0.40NA WA EA 364
    rs748452301,2
    		C,--202314957(+) ACATGG/TTGAAA 3 -- int1 us2k10--------
    rs1899032491,2
    		--202315041(+) GCTGAA/GGCAGG 3 -- int1 us2k10--------
    rs67176411,2
    		C,F,A,H,--202315207(+) TTTCTC/TACCTC 3 -- int1 us2k1 tfbs321Minor allele frequency- T:0.47NS EA NA WA CSA 2515

    HapMap Linkage Disequilibrium report for STRADB (202252581 - 202345574 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for STRADB: --

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    Disorders / Diseases
    for STRADB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STRADB for disorders           About GeneDecksing

    OMIM gene information: 607333    OMIM disorders: --

    4 diseases for STRADB:    About MalaCards
    amyotrophic lateral sclerosis    lateral sclerosis    amyotrophic lateral sclerosis (als)    neuronitis


    Export disorders for STRADB gene to outside databases

    Publications
    for STRADB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STRADB gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with STRADB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. (PubMed id 11161814)1, 2, 3 Hadano S.... Hayden M.R. (2001)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. (PubMed id 14517248)1, 2 Boudeau J.... Alessi D.R. (2003)
    6. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. (PubMed id 14511394)1, 3 Hawley S.A....Hardie D.G. (2003)
    7. ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. (PubMed id 12048196)1, 2 Sanna M.G.... Ulevitch R.J. (2002)
    8. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    10. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)1 Wang J....He F. (2008)

    External Searches for STRADB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing STRADB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55437 HGNC: 13205 AceView: ALS2CR2 Ensembl:ENSG00000082146 euGenes: HUgn55437
    ECgene: STRADB H-InvDB: STRADB

    Other Databases showing STRADB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STRADB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STRADB Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for STRADB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STRADB gene:
    Search GeneIP for patents involving STRADB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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