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Aliases for STRADB Gene

Aliases for STRADB Gene

  • STE20-Related Kinase Adaptor Beta 2 3 5
  • Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein 3 4
  • Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 2 2 3
  • Pseudokinase ALS2CR2 3 4
  • STRAD Beta 3 4
  • ALS2CR2 3 4
  • CALS-21 3 4
  • ILPIP 3 4
  • STE20-Related Kinase Adapter Protein Beta 3
  • ILP-Interacting Protein ILPIPA 3
  • ILP-Interacting Protein 4
  • PRO1038 3
  • ILPIPA 3
  • PAPK 3

External Ids for STRADB Gene

Previous HGNC Symbols for STRADB Gene

  • ALS2CR2

Previous GeneCards Identifiers for STRADB Gene

  • GC02P202025
  • GC02P202252
  • GC02P194164

Summaries for STRADB Gene

Entrez Gene Summary for STRADB Gene

  • This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for STRADB Gene

STRADB (STE20-Related Kinase Adaptor Beta) is a Protein Coding gene. Diseases associated with STRADB include Juvenile Amyotrophic Lateral Sclerosis. Among its related pathways are LKB1 signaling events and mTOR signalling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STRADA.

UniProtKB/Swiss-Prot for STRADB Gene

  • Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).

Gene Wiki entry for STRADB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRADB Gene

Genomics for STRADB Gene

Regulatory Elements for STRADB Gene

Enhancers for STRADB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F201431 1.5 FANTOM5 Ensembl ENCODE 12.2 +45.0 45043 2.6 HDAC1 PKNOX1 ARNT TBL1XR1 SIN3A DMAP1 RARA GATA4 GATA2 MIXL1 STRADB TMEM237 ALS2CR12 RNU6-651P ALS2 ENSG00000202008 TRAK2
GH02F201251 1.7 FANTOM5 Ensembl ENCODE 10.6 -129.4 -129368 13.4 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF207 FOS CASP8 ALS2CR12 STRADB ENSG00000273209 PPIL3 CASP10 CLK1 CFLAR FAM126B
GH02F201450 1.1 ENCODE 10.3 +64.3 64323 3.4 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 CASP8 AOX1 STRADB TMEM237 ALS2CR11 ENO1P4 ALS2CR12 TRAK2 GC02P201507
GH02F201208 1 Ensembl ENCODE 10.1 -178.7 -178746 1.8 ZNF384 BMI1 ZNF366 ETV6 CREM CHD2 RFX1 MTA2 TRIM22 EP300 CASP10 CASP8 STRADB LOC105373835 ORC2 PPIL3 MTND5P25 GC02M201164
GH02F201464 0.9 Ensembl ENCODE 10.9 +78.3 78266 3.2 SCRT1 HLF ZIC2 JUND POLR2A SMARCA4 SCRT2 GLIS1 FOS CASP8 STRADB ENO1P4 ALS2CR11 TMEM237 ALS2CR12 TRAK2 GC02P201507
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STRADB on UCSC Golden Path with GeneCards custom track

Genomic Location for STRADB Gene

Chromosome:
2
Start:
201,387,858 bp from pter
End:
201,480,851 bp from pter
Size:
92,994 bases
Orientation:
Plus strand

Genomic View for STRADB Gene

Genes around STRADB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRADB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRADB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRADB Gene

Proteins for STRADB Gene

  • Protein details for STRADB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0K7-STRAB_HUMAN
    Recommended name:
    STE20-related kinase adapter protein beta
    Protein Accession:
    Q9C0K7
    Secondary Accessions:
    • Q5BKY7
    • Q9P1L0

    Protein attributes for STRADB Gene

    Size:
    418 amino acids
    Molecular mass:
    47026 Da
    Quaternary structure:
    • Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Interacts with BIRC4/XIAP. These two proteins are likely to coexist in a complex with TAK1, TRAF6, TAB1 and TAB2.

    Alternative splice isoforms for STRADB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRADB Gene

Post-translational modifications for STRADB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STRADB Gene

Antibody Products

  • Abcam antibodies for STRADB

No data available for DME Specific Peptides for STRADB Gene

Domains & Families for STRADB Gene

Gene Families for STRADB Gene

Protein Domains for STRADB Gene

Suggested Antigen Peptide Sequences for STRADB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0K7

UniProtKB/Swiss-Prot:

STRAB_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STRADB: view

Function for STRADB Gene

Molecular function for STRADB Gene

UniProtKB/Swiss-Prot Function:
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).

Gene Ontology (GO) - Molecular Function for STRADB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 NOT protein kinase activity IDA 14517248
GO:0005515 protein binding IPI 14676191
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with STRADB: view
genes like me logo Genes that share phenotypes with STRADB: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STRADB

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STRADB Gene

Localization for STRADB Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRADB Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STRADB gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for STRADB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 14517248
GO:0005737 cytoplasm IEA,IDA 14517248
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STRADB: view

Pathways & Interactions for STRADB Gene

genes like me logo Genes that share pathways with STRADB: view

Gene Ontology (GO) - Biological Process for STRADB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0006468 NOT protein phosphorylation IDA 14517248
GO:0006611 protein export from nucleus IDA 14517248
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest TAS --
genes like me logo Genes that share ontologies with STRADB: view

No data available for SIGNOR curated interactions for STRADB Gene

Transcripts for STRADB Gene

Unigene Clusters for STRADB Gene

STE20-related kinase adaptor beta:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRADB Gene

No ASD Table

Relevant External Links for STRADB Gene

GeneLoc Exon Structure for
STRADB
ECgene alternative splicing isoforms for
STRADB

Expression for STRADB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STRADB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STRADB Gene

This gene is overexpressed in Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for STRADB Gene

This gene is overexpressed in Urine (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STRADB Gene



Protein tissue co-expression partners for STRADB Gene

NURSA nuclear receptor signaling pathways regulating expression of STRADB Gene:

STRADB

SOURCE GeneReport for Unigene cluster for STRADB Gene:

Hs.652338

mRNA Expression by UniProt/SwissProt for STRADB Gene:

Q9C0K7-STRAB_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, testis, liver and colon.
genes like me logo Genes that share expression patterns with STRADB: view

Primer Products

Orthologs for STRADB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRADB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRADB 34
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia STRADB 34 35
  • 93.24 (n)
cow
(Bos Taurus)
Mammalia STRADB 34 35
  • 93.22 (n)
mouse
(Mus musculus)
Mammalia Stradb 34 16 35
  • 89.71 (n)
rat
(Rattus norvegicus)
Mammalia Stradb 34
  • 89 (n)
oppossum
(Monodelphis domestica)
Mammalia STRADB 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRADB 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves STRADB 34 35
  • 73.38 (n)
lizard
(Anolis carolinensis)
Reptilia STRADB 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stradb 34
  • 67.28 (n)
zebrafish
(Danio rerio)
Actinopterygii STRADB 35
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Stlk 35
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea strd-1 35
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SKM1 35
  • 13 (a)
ManyToMany
CLA4 35
  • 10 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToMany
Species where no ortholog for STRADB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRADB Gene

ENSEMBL:
Gene Tree for STRADB (if available)
TreeFam:
Gene Tree for STRADB (if available)

Paralogs for STRADB Gene

Paralogs for STRADB Gene

(3) SIMAP similar genes for STRADB Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for STRADB Gene

genes like me logo Genes that share paralogs with STRADB: view

Variants for STRADB Gene

Sequence variations from dbSNP and Humsavar for STRADB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_041335 A metastatic melanoma sample
rs1009276 -- 201,458,233(-) TCTGC(A/G)TATTA intron-variant
rs10174023 -- 201,467,509(+) TATTT(C/T)TTAGG intron-variant
rs10176809 -- 201,467,919(+) aacct(C/T)tgagt intron-variant
rs1019299 -- 201,473,007(+) CCCAC(A/G)GGAAC reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for STRADB Gene

Variant ID Type Subtype PubMed ID
nsv979164 CNV duplication 23825009
nsv3111 CNV insertion 18451855
esv3593979 CNV loss 21293372
esv3575325 CNV gain 25503493

Variation tolerance for STRADB Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STRADB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STRADB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRADB Gene

Disorders for STRADB Gene

MalaCards: The human disease database

(1) MalaCards diseases for STRADB Gene - From: GeneCards

Disorder Aliases PubMed IDs
juvenile amyotrophic lateral sclerosis
  • amyotrophic lateral sclerosis, juvenile
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for STRADB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STRADB
genes like me logo Genes that share disorders with STRADB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STRADB Gene

Publications for STRADB Gene

  1. Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. (PMID: 11161814) Hadano S. … Hayden M.R. (Genomics 2001) 2 3 4 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. (PMID: 14511394) Hawley S.A. … Hardie D.G. (J. Biol. 2003) 2 3 64

Products for STRADB Gene

Sources for STRADB Gene

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