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Aliases for STRADA Gene

Aliases for STRADA Gene

  • STE20-Related Kinase Adaptor Alpha 2 3 5
  • Serologically Defined Breast Cancer Antigen NY-BR-96 3 4
  • STE20-Like Pseudokinase 2 3
  • STRAD Alpha 3 4
  • STRAD 3 4
  • LYK5 3 4
  • STE20-Related Adapter Protein 4
  • Protein Kinase LYK5 3
  • NY-BR-96 3
  • PMSE 3
  • Stlk 3

External Ids for STRADA Gene

Previous GeneCards Identifiers for STRADA Gene

  • GC17M059134
  • GC17M061780
  • GC17M057148

Summaries for STRADA Gene

Entrez Gene Summary for STRADA Gene

  • The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]

GeneCards Summary for STRADA Gene

STRADA (STE20-Related Kinase Adaptor Alpha) is a Protein Coding gene. Diseases associated with STRADA include polyhydramnios, megalencephaly, and symptomatic epilepsy and polyhydramnios. Among its related pathways are Signaling by GPCR and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is OXSR1.

UniProtKB/Swiss-Prot for STRADA Gene

  • Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

Gene Wiki entry for STRADA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRADA Gene

Genomics for STRADA Gene

Regulatory Elements for STRADA Gene

Promoters for STRADA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STRADA on UCSC Golden Path with GeneCards custom track

Genomic Location for STRADA Gene

Chromosome:
17
Start:
63,702,832 bp from pter
End:
63,741,970 bp from pter
Size:
39,139 bases
Orientation:
Minus strand

Genomic View for STRADA Gene

Genes around STRADA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRADA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRADA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRADA Gene

Proteins for STRADA Gene

  • Protein details for STRADA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTN6-STRAA_HUMAN
    Recommended name:
    STE20-related kinase adapter protein alpha
    Protein Accession:
    Q7RTN6
    Secondary Accessions:
    • B4DDE3
    • B4DW17
    • J3KTC9
    • Q5JPI2
    • Q7Z4K9
    • Q8NC31
    • Q8NCF1
    • Q9H272

    Protein attributes for STRADA Gene

    Size:
    431 amino acids
    Molecular mass:
    48369 Da
    Quaternary structure:
    • Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

    Three dimensional structures from OCA and Proteopedia for STRADA Gene

    Alternative splice isoforms for STRADA Gene

neXtProt entry for STRADA Gene

Proteomics data for STRADA Gene at MOPED

Post-translational modifications for STRADA Gene

  • Ubiquitination at Lys 239
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for STRADA Gene

Domains & Families for STRADA Gene

Gene Families for STRADA Gene

Protein Domains for STRADA Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7RTN6

UniProtKB/Swiss-Prot:

STRAA_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STRADA: view

Function for STRADA Gene

Molecular function for STRADA Gene

UniProtKB/Swiss-Prot Function:
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

Gene Ontology (GO) - Molecular Function for STRADA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030295 protein kinase activator activity IDA 19892943
genes like me logo Genes that share ontologies with STRADA: view
genes like me logo Genes that share phenotypes with STRADA: view

Human Phenotype Ontology for STRADA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for STRADA Gene

miRTarBase miRNAs that target STRADA

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for STRADA Gene

Localization for STRADA Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRADA Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STRADA Gene COMPARTMENTS Subcellular localization image for STRADA gene
Compartment Confidence
nucleus 5
cytosol 4

No data available for Gene Ontology (GO) - Cellular Components for STRADA Gene

Pathways & Interactions for STRADA Gene

genes like me logo Genes that share pathways with STRADA: view

Pathways by source for STRADA Gene

Gene Ontology (GO) - Biological Process for STRADA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006611 protein export from nucleus IDA 12805220
GO:0071902 positive regulation of protein serine/threonine kinase activity IDA 19892943
genes like me logo Genes that share ontologies with STRADA: view

No data available for SIGNOR curated interactions for STRADA Gene

Drugs & Compounds for STRADA Gene

No Compound Related Data Available

Transcripts for STRADA Gene

Unigene Clusters for STRADA Gene

STE20-related kinase adaptor alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STRADA Gene

No ASD Table

Relevant External Links for STRADA Gene

GeneLoc Exon Structure for
STRADA
ECgene alternative splicing isoforms for
STRADA

Expression for STRADA Gene

mRNA expression in normal human tissues for STRADA Gene

Protein differential expression in normal tissues from HIPED for STRADA Gene

This gene is overexpressed in Plasma (17.2), Testis (17.2), and Ovary (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STRADA Gene



SOURCE GeneReport for Unigene cluster for STRADA Gene Hs.514402

genes like me logo Genes that share expression patterns with STRADA: view

Protein tissue co-expression partners for STRADA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STRADA Gene

Orthologs for STRADA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRADA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRADA 35
  • 96.2 (n)
  • 95.44 (a)
STRADA 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STRADA 36
  • 95 (a)
OneToOne
STRADA 35
  • 89.1 (n)
  • 95.44 (a)
dog
(Canis familiaris)
Mammalia STRADA 35
  • 92.81 (n)
  • 96.75 (a)
STRADA 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Strada 16
Strada 36
  • 95 (a)
OneToOne
Strada 35
  • 88.71 (n)
  • 95.13 (a)
oppossum
(Monodelphis domestica)
Mammalia STRADA 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRADA 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Strada 35
  • 88.17 (n)
  • 93.06 (a)
chicken
(Gallus gallus)
Aves STRADA 36
  • 86 (a)
OneToOne
STRADA 35
  • 76.07 (n)
  • 86.03 (a)
lizard
(Anolis carolinensis)
Reptilia STRADA 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia strada 35
  • 72.46 (n)
  • 78.63 (a)
zebrafish
(Danio rerio)
Actinopterygii strada 36
  • 70 (a)
OneToOne
strada 35
  • 69.88 (n)
  • 71.58 (a)
wufj99g05 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007805 35
  • 51.83 (n)
  • 40.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Stlk 36
  • 33 (a)
OneToMany
Stlk 35
  • 42.89 (n)
  • 37.54 (a)
worm
(Caenorhabditis elegans)
Secernentea strd-1 35
  • 44.75 (n)
  • 35.8 (a)
strd-1 36
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLA4 36
  • 10 (a)
ManyToMany
SKM1 36
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for STRADA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRADA Gene

ENSEMBL:
Gene Tree for STRADA (if available)
TreeFam:
Gene Tree for STRADA (if available)

Paralogs for STRADA Gene

Paralogs for STRADA Gene

Pseudogenes.org Pseudogenes for STRADA Gene

genes like me logo Genes that share paralogs with STRADA: view

Variants for STRADA Gene

Sequence variations from dbSNP and Humsavar for STRADA Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs35808156 - 63,726,695(+) CCACC(A/G)CTAAA intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs56271007 - 63,714,053(+) AGCTA(A/C)TCATG intron-variant, nc-transcript-variant, reference, missense
rs55695051 - 63,714,042(+) CTCTG(A/G)CAGAA intron-variant, nc-transcript-variant, reference, missense
rs1470697 -- 63,722,480(+) GGTCT(C/T)CAGAT intron-variant
rs1271517 -- 63,728,499(-) TGGTA(A/G)ACCTG intron-variant

Variation tolerance for STRADA Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STRADA Gene

HapMap Linkage Disequilibrium report
STRADA
Human Gene Mutation Database (HGMD)
STRADA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for STRADA Gene

Disorders for STRADA Gene

MalaCards: The human disease database

(6) MalaCards diseases for STRADA Gene - From: OMIM, ClinVar, GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
polyhydramnios, megalencephaly, and symptomatic epilepsy
  • polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome
polyhydramnios
scheuermann's disease
  • juvenile osteochondritis of the spine
megalencephaly
  • macrencephaly
spinocerebellar ataxia 40
  • spinocerebellar ataxia type 40
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

STRAA_HUMAN
  • Note=A homozygous 7-kb deletion involving STRADA is a cause of a syndrome characterized by polyhydramnios, megalencephaly and symptomatic epilepsy.

Relevant External Links for STRADA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STRADA
genes like me logo Genes that share disorders with STRADA: view

No data available for Genatlas for STRADA Gene

Publications for STRADA Gene

  1. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. (PMID: 12805220) Baas A.F. … Clevers H.C. (EMBO J. 2003) 2 3 4 23 67
  2. Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization. (PMID: 17921699) Marignani P.A. … Resta N. (Cancer Biol. Ther. 2007) 2 3
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. (PMID: 25241761) Chen T.C. … Huang C.Y. (J. Proteome Res. 2014) 3

Products for STRADA Gene

Sources for STRADA Gene

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