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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STRADA Gene

protein-coding   GIFtS: 54
GCID: GC17M061780

STE20-Related Kinase Adaptor Alpha

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
STE20-Related Kinase Adaptor Alpha1 2     NY-BR-962
LYK52 3 5     PMSE2
STRAD2 3 5     Stlk2
STE20-Like Pseudokinase1 2     Protein Kinase LYK52
Serologically Defined Breast Cancer Antigen NY-BR-962 3     STE20-Related Kinase Adapter Protein Alpha2
STRAD Alpha2 3     STE20-Related Adapter Protein3

External Ids:    HGNC: 301721   Entrez Gene: 923352   Ensembl: ENSG000002661737   OMIM: 6086265   UniProtKB: Q7RTN63   

Export aliases for STRADA gene to outside databases

Previous GC identifers: GC17M059134 GC17M057148


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STRADA Gene:
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical
for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with
serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39
(CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and
excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in
this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome.
Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript
variants have been described but their full-length nature is not known. (provided by RefSeq, Sep 2009)

GeneCards Summary for STRADA Gene: 
STRADA (STE20-related kinase adaptor alpha) is a protein-coding gene. Diseases associated with STRADA include polyhydramnios, and megalencephaly, and among its related super-pathways are Insulin receptor signalling cascade and Energy dependent regulation of mTOR by LKB1-AMPK. GO annotations related to this gene include kinase binding and protein serine/threonine kinase activity. An important paralog of this gene is STRADB.

UniProtKB/Swiss-Prot: STRAA_HUMAN, Q7RTN6
Function: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and
activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a
pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation

Gene Wiki entry for STRADA (LYK5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STRADA gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   AML1a   POU2F2   AREB6   POU2F1   POU2F1a   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTRADA promoter sequence
   Search SABiosciences Chromatin IP Primers for STRADA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STRADA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q23.3

STRADA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STRADA gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M061780:  view genomic region     (about GC identifiers)

Start:
61,780,192 bp from pter      End:
61,819,330 bp from pter
Size:
39,139 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STRAA_HUMAN, Q7RTN6 (See protein sequence)
Recommended Name: STE20-related kinase adapter protein alpha  
Size: 431 amino acids; 48369 Da
Subunit: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25
(CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its
catalytic activity
Subcellular location: Nucleus. Cytoplasm
3 PDB 3D structures from and Proteopedia for STRADA:
1UPK (3D)        2WTK (3D)        3GNI (3D)    
Secondary accessions: B4DDE3 B4DW17 J3KTC9 Q5JPI2 Q7Z4K9 Q8NC31 Q8NCF1 Q9H272
Alternative splicing: 6 isoforms:  Q7RTN6-1   Q7RTN6-2   Q7RTN6-3   Q7RTN6-4   Q7RTN6-5   Q7RTN6-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STRADA: NX_Q7RTN6

Explore proteomics data for STRADA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7RTN6

  • STRADA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STRADA Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001003786.1  NP_001003787.1  NP_001003788.1  NP_001159441.1  NP_001159442.1  NP_699166.2  

    ENSEMBL proteins: 
     ENSP00000245865   ENSP00000365000   ENSP00000376677   ENSP00000336655   ENSP00000464213  
     ENSP00000398841   ENSP00000462922   ENSP00000462530   ENSP00000464547   ENSP00000463872  
     ENSP00000464085   ENSP00000463203   ENSP00000462384   ENSP00000464139   ENSP00000462496  
     ENSP00000463238  
    Reactome Protein details: Q7RTN6
    Human Recombinant Protein Products for STRADA: 
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    Novus Biologicals STRADA Proteins
    Novus Biologicals STRADA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12805220
    GO:0005737cytoplasm IDA12805220
    GO:0005829cytosol TAS--

    STRADA for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: STE20-related kinase adaptor alpha 
    STLK subfamily

    2 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q7RTN6

    ProtoNet protein and cluster: Q7RTN6

    UniProtKB/Swiss-Prot: STRAA_HUMAN, Q7RTN6
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    STRADA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STRAA_HUMAN, Q7RTN6
    Function: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and
    activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a
    pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672NOT protein kinase activity IDA12805220
    GO:0004674contributes to protein serine/threonine kinase activity IDA19892943
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12805220
    GO:0005524ATP binding IEA--
         
    STRADA for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for STRADA:
     Decreased substrate adherent c  Decreased telomerase activity  Increased G1 DNA content  Synthetic lethal with Ras 
     Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for STRADA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STRADA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STRADA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STRADA 

    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate STRADA (see all 9):
    hsa-miR-3647-3p hsa-miR-4282 hsa-miR-432 hsa-miR-373* hsa-miR-375 hsa-miR-590-3p hsa-miR-616* hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidSTRADA 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRADA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STRADA About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1IRS-related events
    Insulin receptor signalling cascade0.94
    IGF1R signaling cascade0.92
    IRS-related events0.94
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    IRS-related events triggered by IGF1R0.93
    PI3K Cascade0.86
    IRS-mediated signalling0.92
    Signaling by Insulin receptor0.79
    2Energy dependent regulation of mTOR by LKB1-AMPK
    Energy dependent regulation of mTOR by LKB1-AMPK0.82
    mTOR signalling0.63
    Regulation of AMPK activity via LKB10.82
    PKB-mediated events0.61
    3Signaling by GPCR
    Signal Transduction0.55
    4Translation Insulin regulation of translation
    mTOR signaling pathway0.34
    5LKB1 signaling events
    LKB1 signaling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for STRADA
        AMPK signaling
    Integrated Pancreatic Cancer Pathway
    LKB1 signaling events

    5/13        Reactome Pathways for STRADA (see all 13)
        PI3K Cascade
    Regulation of AMPK activity via LKB1
    IGF1R signaling cascade
    mTOR signalling
    Energy dependent regulation of mTOR by LKB1-AMPK


    1         Kegg Pathway  (Kegg details for STRADA):
        mTOR signaling pathway


    STRADA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STRADA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/25 Interacting proteins for STRADA (Q7RTN61, 2, 3 ENSP000003366554) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK11Q158311, 2, 3, ENSP000003248564EBI-1109114,EBI-306838 MINT-56666 MINT-56665 I2D: score=6 STRING: ENSP00000324856
    CAB39Q9Y3762, 3, ENSP000002584184MINT-8186774 MINT-8186758 MINT-8186742 I2D: score=3 STRING: ENSP00000258418
    SMAD4Q134853I2D: score=1 
    STK25O005063I2D: score=1 
    ACACBENSP000003670794STRING: ENSP00000367079
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468NOT protein phosphorylation IDA12805220
    GO:0006611protein export from nucleus IDA12805220
    GO:0007050cell cycle arrest TAS--
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0032147activation of protein kinase activity IDA12805220

    STRADA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STRADA (STRAA)

    Search CenterWatch for drugs/clinical trials and news about STRADA / STRAA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STRADA gene (6 alternative transcripts): 
    NM_001003786.2  NM_001003787.2  NM_001003788.2  NM_001165969.1  NM_001165970.1  NM_153335.5  

    Unigene Cluster for STRADA:

    STE20-related kinase adaptor alpha
    Hs.514402  [show with all ESTs]
    Unigene Representative Sequence: BC043641
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000245865(uc002jbr.3) ENST00000375840 ENST00000583085 ENST00000392950(uc002jbm.3 uc002jbn.3 uc010wpq.2 uc010wpr.2 uc002jbo.3 uc002jbp.3 uc010ddw.3)
    ENST00000336174 ENST00000582026 ENST00000447001 ENST00000582137 ENST00000580039
    ENST00000579340 ENST00000578008 ENST00000578801 ENST00000581243 ENST00000581505
    ENST00000577375 ENST00000580338 ENST00000579549 ENST00000582030
    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate STRADA (see all 9):
    hsa-miR-3647-3p hsa-miR-4282 hsa-miR-432 hsa-miR-373* hsa-miR-375 hsa-miR-590-3p hsa-miR-616* hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidSTRADA 3' UTR sequence
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRADA
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    Additional mRNA sequence: 

    AF308302.1 AK074771.1 AK075005.1 AK092342.1 AK293160.1 AK301331.1 AL832407.1 AY290821.2 
    BC043641.1 

    24/28 DOTS entries (see all 28):

    DT.86840052  DT.75122243  DT.100810170  DT.444727  DT.92428548  DT.100810162  DT.120925597  DT.65286068 
    DT.100832950  DT.100810163  DT.120925397  DT.120925514  DT.100810159  DT.120925556  DT.100810164  DT.95365775 
    DT.100810172  DT.120925562  DT.40127556  DT.91863466  DT.100739525  DT.120925503  DT.40309429  DT.92428543 

    15 AceView cDNA sequences:

    AL832407 CR601269 AY290821 NM_001003787 AK074771 CR601658 NM_001003786 NM_153335 
    NM_001003788 CR593241 AF308302 BK001542 AK128173 BC043641 AK075005 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STRADA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCCTTCGC
    STRADA Expression
    About this image


    See STRADA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STRADA

    SOURCE GeneReport for Unigene cluster: Hs.514402
        SABiosciences Custom PCR Arrays for STRADA
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRADA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for STRADA gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Strada1 , 5 STE20-related kinase adaptor alpha1, 5 88.71(n)1
    95.13(a)1
      11 (68.89 cM)5
    721491  NM_001252448.11  NP_001239377.11 
     1061633305 
    chicken
    (Gallus gallus)
    Aves STRADA1 STE20-related kinase adaptor alpha 76.07(n)
    86.03(a)
      419957  NM_001012844.1  NP_001012862.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    STRADA6
    Uncharacterized protein

    85(a)
    possible ortholog
    1 ↔ 1
    AAWZ02036400(8712-25166)
    6(60809611-60826424)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377317842   -- 72.73(n)    137731784 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj99g052 wufj99g05 70.4(n)   334550  BC047830.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Stlk1 Ste20-like kinase 42.89(n)
    37.54(a)
      3355135  NM_001042977.2  NP_001036442.1 
    worm
    (Caenorhabditis elegans)
    Secernentea strd-16
    Protein STRD-1, isoform a
    25(a)
    1 → many
    III(10947442-10951169)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPS16
    Putative protein serine/threonine kinase expressed...
    17(a)
    1 → many
    IV(1485566-1487038)


    ENSEMBL Gene Tree for STRADA (if available)
    TreeFam Gene Tree for STRADA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STRADA gene
    STRADB2  OXSR12  STK392  
    14 SIMAP similar genes for STRADA using alignment to 11 protein entries:     STRAA_HUMAN (see all proteins):
    STRADB    BRAF    STK25    OXSR1    STK4    STK3
    MST4    MAP4K5    MARK2    STK24    PAK3    PAK1
    MAP4K1    MINK1

    STRADA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STRADA
    PGOHUM00000245090


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/876 SNPs in STRADA are shown (see all 876)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs611515021,2
    C--61781336(+) AGAAC-/CAGAAC
            
    GAAGG
    6 -- cds10--------
    rs93034651,2
    C,A--61785251(+) acgccC/Tggcta 6 -- int10--------
    rs58214011,2
    C--61790360(+) AAAAA-/A/AA  
            
    GAAAA
    6 -- int11CSA 2
    rs1130312241,2
    C,F--61793648(+) GATGGG/AGTTTT 6 -- int11Minor allele frequency- A:0.50CSA 2
    rs1118462041,2
    F--61794863(+) TTAGAG/CAGACT 6 -- int11Minor allele frequency- C:0.50CSA 2
    rs1117258441,2
    C--61798002(+) GGCAGC/TGGGCA 6 -- int10--------
    rs1123550801,2
    C,F--61798817(+) CTCACG/ACCTGT 6 -- int11Minor allele frequency- A:0.50WA 2
    rs2000122231,2
    C--61801806(+) TTTTT-/TGAGAC 6 -- int10--------
    rs1130896801,2
    F--61802893(+) TTTTAG/ATAGAG 6 -- int11Minor allele frequency- A:0.50CSA 2
    rs58214021,2
    C--61805369(+) CTCAC-/GGGGGG 6 -- int10--------

    HapMap Linkage Disequilibrium report for STRADA (61780192 - 61819330 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for STRADA: --

    Human Gene Mutation Database (HGMD): STRADA
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing STRADA
    DNA2.0 Custom Variant and Variant Library Synthesis for STRADA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608626   
    OMIM disorders: 611087  
    UniProtKB/Swiss-Prot: STRAA_HUMAN, Q7RTN6
  • Note=A homozygous 7-kb deletion involving STRADA is a cause of a syndrome characterized by
    polyhydramnios, megalencephaly and symptomatic epilepsy

  • 9 diseases for STRADA:    About MalaCards
    polyhydramnios    megalencephaly    polyhydramnios, megalencephaly, and symptomatic epilepsy    epilepsy syndrome
    peutz-jeghers syndrome    breast cancer    gout    pancreatic cancer
    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for STRADA:
    Peutz-Jeghers syndrome     Polyhydramnios

    STRADA for disorders           About GeneDecksing


    Export disorders for STRADA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STRADA gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with STRADA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. (PubMed id 12805220)1, 2, 3, 9 Baas A.F.... Clevers H.C. (2003)
    2. Structure of the LKB1-STRAD-MO25 complex reveals an a llosteric mechanism of kinase activation. (PubMed id 19892943)1, 2 Zeqiraj E....van Aalten D.M. (2009)
    3. Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization. (PubMed id 17921699)1, 3 Marignani P.A....Resta N. (2007)
    4. Crystal structure of MO25 alpha in complex with the C-terminus of the pseudo kinase STE20-related adaptor. (PubMed id 14730349)1, 2 Milburn C.C.... van Aalten D.M. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. (PubMed id 14517248)1, 2 Boudeau J.... Alessi D.R. (2003)
    7. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PubMed id 12747765)1, 2 Scanlan M.J.... Old L.J. (2001)
    8. Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5. (PubMed id 17522105)2, 9 Puffenberger E.G.... Morton D.H. (2007)
    9. Sequence and structural analyses of nuclear export sig nals in the NESdb database. (PubMed id 22833565)1 Xu D....Chook Y.M. (2012)
    10. Molecular chaperone complexes with antagonizing activi ties regulate stability and activity of the tumor suppressor LKB1. (PubMed id 21860411)1 Gaude H....Forcet C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92335 HGNC: 30172 AceView: LYK5 Ensembl:ENSG00000266173 euGenes: HUgn92335
    ECgene: STRADA Kegg: 92335 H-InvDB: STRADA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STRADA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STRADA gene:
    Search GeneIP for patents involving STRADA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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