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Aliases for STRADA Gene

Aliases for STRADA Gene

  • STE20-Related Kinase Adaptor Alpha 2 3 5
  • Serologically Defined Breast Cancer Antigen NY-BR-96 3 4
  • STE20-Like Pseudokinase 2 3
  • STRAD Alpha 3 4
  • STRAD 3 4
  • LYK5 3 4
  • STE20-Related Kinase Adapter Protein Alpha 3
  • STE20-Related Adapter Protein 4
  • Protein Kinase LYK5 3
  • NY-BR-96 3
  • PMSE 3
  • Stlk 3

External Ids for STRADA Gene

Previous GeneCards Identifiers for STRADA Gene

  • GC17M059134
  • GC17M061780
  • GC17M057148
  • GC17M063703

Summaries for STRADA Gene

Entrez Gene Summary for STRADA Gene

  • The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]

GeneCards Summary for STRADA Gene

STRADA (STE20-Related Kinase Adaptor Alpha) is a Protein Coding gene. Diseases associated with STRADA include Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy and Polyhydramnios. Among its related pathways are RET signaling and mTOR signaling pathway (KEGG). GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STRADB.

UniProtKB/Swiss-Prot for STRADA Gene

  • Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

Gene Wiki entry for STRADA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRADA Gene

Genomics for STRADA Gene

Regulatory Elements for STRADA Gene

Enhancers for STRADA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G063674 2 VISTA Ensembl ENCODE dbSUPER 11.2 +66.0 66005 3.5 HDGF ZFP64 SIN3A GATA2 ZNF207 FOS DEK ZHX2 REST ZNF592 FTSJ3 LIMD2 STRADA ENSG00000125695 TACO1 LOC101927898 EEF1DP7
GH17G062789 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +949.8 949829 5.9 HDGF PKNOX1 FOXA2 SIN3A YBX1 FEZF1 ZBTB7B ZNF207 FOS SP3 DDX42 INTS2 MED13 MIR633 STRADA MARCH10 GC17M062789 GC17M062752
GH17G063783 1.4 ENCODE dbSUPER 11.8 -44.2 -44156 4.3 HDGF FOXA2 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 FTSJ3 PSMC5 ENSG00000125695 STRADA MAP3K3 PIR56411 CCDC47
GH17G063694 1.3 ENCODE dbSUPER 12.3 +42.7 42715 10.2 HDGF PKNOX1 AGO1 WRNIP1 ARID4B SIN3A ZNF48 ZBTB7B GLIS2 ELK1 FTSJ3 CSH2 STRADA ENSG00000125695 PSMC5 TCAM1P PIR54058 GC17M063699 GC17M063698
GH17G063704 1 ENCODE dbSUPER 12.4 +35.2 35247 3.8 MTA2 NR2F1 CEBPB TRIM22 MAFG NFXL1 TBX21 ZNF316 NBN ETV6 FTSJ3 CSH2 STRADA ENSG00000125695 PSMC5 TACO1 LIMD2 PIR56154
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STRADA on UCSC Golden Path with GeneCards custom track

Promoters for STRADA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000096836 170 2401 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF610

Genomic Location for STRADA Gene

Chromosome:
17
Start:
63,682,336 bp from pter
End:
63,741,986 bp from pter
Size:
59,651 bases
Orientation:
Minus strand

Genomic View for STRADA Gene

Genes around STRADA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRADA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRADA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRADA Gene

Proteins for STRADA Gene

  • Protein details for STRADA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTN6-STRAA_HUMAN
    Recommended name:
    STE20-related kinase adapter protein alpha
    Protein Accession:
    Q7RTN6
    Secondary Accessions:
    • B4DDE3
    • B4DW17
    • J3KTC9
    • Q5JPI2
    • Q7Z4K9
    • Q8NC31
    • Q8NCF1
    • Q9H272

    Protein attributes for STRADA Gene

    Size:
    431 amino acids
    Molecular mass:
    48369 Da
    Quaternary structure:
    • Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

    Three dimensional structures from OCA and Proteopedia for STRADA Gene

    Alternative splice isoforms for STRADA Gene

neXtProt entry for STRADA Gene

Post-translational modifications for STRADA Gene

  • Ubiquitination at isoforms=2, 3, 4, 5, 6239
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STRADA Gene

Domains & Families for STRADA Gene

Gene Families for STRADA Gene

Protein Domains for STRADA Gene

Graphical View of Domain Structure for InterPro Entry

Q7RTN6

UniProtKB/Swiss-Prot:

STRAA_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STRADA: view

Function for STRADA Gene

Molecular function for STRADA Gene

UniProtKB/Swiss-Prot Function:
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

Gene Ontology (GO) - Molecular Function for STRADA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 NOT protein kinase activity IEA,IDA 12805220
GO:0005515 protein binding IPI 12805220
GO:0005524 ATP binding IEA --
GO:0019900 kinase binding IPI 19892943
GO:0030295 protein kinase activator activity IDA 19892943
genes like me logo Genes that share ontologies with STRADA: view
genes like me logo Genes that share phenotypes with STRADA: view

Human Phenotype Ontology for STRADA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for STRADA Gene

miRTarBase miRNAs that target STRADA

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for STRADA Gene

Localization for STRADA Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRADA Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STRADA gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for STRADA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 12805220
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 12805220
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STRADA: view

Pathways & Interactions for STRADA Gene

genes like me logo Genes that share pathways with STRADA: view

Pathways by source for STRADA Gene

Gene Ontology (GO) - Biological Process for STRADA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 NOT protein phosphorylation IDA,IEA 12805220
GO:0006611 protein export from nucleus IDA 12805220
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest TAS --
GO:0032147 activation of protein kinase activity IDA 12805220
genes like me logo Genes that share ontologies with STRADA: view

No data available for SIGNOR curated interactions for STRADA Gene

Drugs & Compounds for STRADA Gene

No Compound Related Data Available

Transcripts for STRADA Gene

Unigene Clusters for STRADA Gene

STE20-related kinase adaptor alpha:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRADA Gene

No ASD Table

Relevant External Links for STRADA Gene

GeneLoc Exon Structure for
STRADA
ECgene alternative splicing isoforms for
STRADA

Expression for STRADA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STRADA Gene

Protein differential expression in normal tissues from HIPED for STRADA Gene

This gene is overexpressed in Plasma (17.2), Testis (17.2), and Ovary (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STRADA Gene



Protein tissue co-expression partners for STRADA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STRADA Gene:

STRADA

SOURCE GeneReport for Unigene cluster for STRADA Gene:

Hs.514402

Evidence on tissue expression from TISSUES for STRADA Gene

  • Lymph node(4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for STRADA Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • cheek
  • chin
  • eye
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • skull
Pelvis:
  • placenta
  • uterus
General:
  • skin
genes like me logo Genes that share expression patterns with STRADA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STRADA Gene

Orthologs for STRADA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRADA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRADA 34 35
  • 96.2 (n)
dog
(Canis familiaris)
Mammalia STRADA 34 35
  • 92.81 (n)
oppossum
(Monodelphis domestica)
Mammalia STRADA 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STRADA 34 35
  • 89.1 (n)
mouse
(Mus musculus)
Mammalia Strada 34 16 35
  • 88.71 (n)
rat
(Rattus norvegicus)
Mammalia Strada 34
  • 88.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STRADA 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves STRADA 34 35
  • 76.07 (n)
lizard
(Anolis carolinensis)
Reptilia STRADA 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia strada 34
  • 72.46 (n)
zebrafish
(Danio rerio)
Actinopterygii strada 34 35
  • 69.88 (n)
wufj99g05 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007805 34
  • 51.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta Stlk 34 35
  • 42.89 (n)
worm
(Caenorhabditis elegans)
Secernentea strd-1 34 35
  • 44.75 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SKM1 35
  • 13 (a)
ManyToMany
CLA4 35
  • 10 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToMany
Species where no ortholog for STRADA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRADA Gene

ENSEMBL:
Gene Tree for STRADA (if available)
TreeFam:
Gene Tree for STRADA (if available)

Paralogs for STRADA Gene

Paralogs for STRADA Gene

Pseudogenes.org Pseudogenes for STRADA Gene

genes like me logo Genes that share paralogs with STRADA: view

Variants for STRADA Gene

Sequence variations from dbSNP and Humsavar for STRADA Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs886037929 Pathogenic 63,706,650(-) AAGGA(-/A)TATGC nc-transcript-variant, reference, frameshift-variant
rs1057519011 Uncertain significance 63,706,701(-) TACAG(A/T)GTGGG nc-transcript-variant, reference, missense
rs56163554 Uncertain significance 63,714,097(+) GAGCT(C/T)GCATC intron-variant, nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs1000046317 -- 63,724,837(+) TTCCA(A/G)CTAAA intron-variant
rs1000048620 -- 63,711,621(+) CAGCC(C/T)AAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STRADA Gene

Variant ID Type Subtype PubMed ID
nsv575854 CNV loss 21841781

Variation tolerance for STRADA Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STRADA Gene

Human Gene Mutation Database (HGMD)
STRADA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STRADA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRADA Gene

Disorders for STRADA Gene

MalaCards: The human disease database

(4) MalaCards diseases for STRADA Gene - From: OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
polyhydramnios, megalencephaly, and symptomatic epilepsy
  • polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome
polyhydramnios
scheuermann disease
  • scheuermann's disease
megalencephaly
  • macroencephaly
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

STRAA_HUMAN
  • Note=A homozygous 7-kb deletion involving STRADA is a cause of a syndrome characterized by polyhydramnios, megalencephaly and symptomatic epilepsy.

Relevant External Links for STRADA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STRADA
genes like me logo Genes that share disorders with STRADA: view

No data available for Genatlas for STRADA Gene

Publications for STRADA Gene

  1. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. (PMID: 12805220) Baas A.F. … Clevers H.C. (EMBO J. 2003) 2 3 4 22 64
  2. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. (PMID: 19892943) Zeqiraj E. … van Aalten D.M. (Science 2009) 3 4 64
  3. Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization. (PMID: 17921699) Marignani P.A. … Resta N. (Cancer Biol. Ther. 2007) 2 3 64
  4. Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5. (PMID: 17522105) Puffenberger E.G. … Morton D.H. (Brain 2007) 4 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for STRADA Gene

Sources for STRADA Gene

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