Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



STRADA Gene

protein-coding   GIFtS: 54
GCID: GC17M061780

STE20-Related Kinase Adaptor Alpha

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
STE20-Related Kinase Adaptor Alpha1 2     NY-BR-962
LYK52 3 5     PMSE2
STRAD2 3 5     Stlk2
STE20-Like Pseudokinase1 2     Protein Kinase LYK52
Serologically Defined Breast Cancer Antigen NY-BR-962 3     STE20-Related Kinase Adapter Protein Alpha2
STRAD Alpha2 3     STE20-Related Adapter Protein3

External Ids:    HGNC: 301721   Entrez Gene: 923352   Ensembl: ENSG000002661737   OMIM: 6086265   UniProtKB: Q7RTN63   

Export aliases for STRADA gene to outside databases

Previous GC identifers: GC17M059134 GC17M057148


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for STRADA Gene:
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical
for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with
serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39
(CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and
excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in
this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome.
Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript
variants have been described but their full-length nature is not known. (provided by RefSeq, Sep 2009)

GeneCards Summary for STRADA Gene:
STRADA (STE20-related kinase adaptor alpha) is a protein-coding gene. Diseases associated with STRADA include polyhydramnios, and polyhydramnios, megalencephaly, and symptomatic epilepsy. GO annotations related to this gene include kinase binding and protein serine/threonine kinase activity. An important paralog of this gene is STRADB.

UniProtKB/Swiss-Prot: STRAA_HUMAN, Q7RTN6
Function: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and
activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a
pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation

Gene Wiki entry for STRADA (LYK5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STRADA gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   AML1a   POU2F2   AREB6   POU2F1   POU2F1a   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTRADA promoter sequence
   Search Chromatin IP Primers for STRADA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STRADA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q23.3

STRADA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STRADA gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M061780:  view genomic region     (about GC identifiers)

Start:
61,780,192 bp from pter      End:
61,819,330 bp from pter
Size:
39,139 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: STRAA_HUMAN, Q7RTN6 (See protein sequence)
Recommended Name: STE20-related kinase adapter protein alpha  
Size: 431 amino acids; 48369 Da
Subunit: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25
(CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its
catalytic activity
3 PDB 3D structures from and Proteopedia for STRADA:
1UPK (3D)        2WTK (3D)        3GNI (3D)    
Secondary accessions: B4DDE3 B4DW17 J3KTC9 Q5JPI2 Q7Z4K9 Q8NC31 Q8NCF1 Q9H272
Alternative splicing: 6 isoforms:  Q7RTN6-1   Q7RTN6-2   Q7RTN6-3   Q7RTN6-4   Q7RTN6-5   Q7RTN6-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STRADA: NX_Q7RTN6

Explore proteomics data for STRADA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys239
  • Modification sites at PhosphoSitePlus

  • See STRADA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001003786.1  NP_001003787.1  NP_001003788.1  NP_001159441.1  NP_001159442.1  NP_699166.2  

    ENSEMBL proteins: 
     ENSP00000245865   ENSP00000365000   ENSP00000376677   ENSP00000336655   ENSP00000464213  
     ENSP00000398841   ENSP00000462922   ENSP00000462530   ENSP00000464547   ENSP00000463872  
     ENSP00000464085   ENSP00000463203   ENSP00000462384   ENSP00000464139   ENSP00000462496  
     ENSP00000463238  
    Reactome Protein details: Q7RTN6

    STRADA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for STRADA
    OriGene Protein Over-expression Lysate for STRADA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for STRADA
    GenScript Custom Purified and Recombinant Proteins Services for STRADA
    Novus Biologicals STRADA Proteins
    Novus Biologicals STRADA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    STRADA Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for STRADA
    OriGene Custom Antibody Services for STRADA
    Novus Biologicals STRADA Antibodies
    Abcam antibodies for STRADA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for STRADA
    LSBio Antibodies in human, mouse, rat for STRADA

    STRADA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STRADA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STRADA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: STE20-related kinase adaptor alpha
    STLK subfamily

    2 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q7RTN6

    ProtoNet protein and cluster: Q7RTN6

    UniProtKB/Swiss-Prot: STRAA_HUMAN, Q7RTN6
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    STRADA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STRAA_HUMAN, Q7RTN6
    Function: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and
    activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a
    pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672NOT protein kinase activity IDA12805220
    GO:0004674contributes to protein serine/threonine kinase activity IDA19892943
    GO:0004702NOT receptor signaling protein serine/threonine kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12805220
         
    STRADA for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for STRADA:
     Decreased substrate adherent c  Decreased telomerase activity  Increased G1 DNA content  Synthetic lethal with Ras 
     Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STRADA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STRADA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STRADA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STRADA

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat STRADA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STRADA (see all 9):
    hsa-miR-3647-3p hsa-miR-4282 hsa-miR-432 hsa-miR-373* hsa-miR-375 hsa-miR-590-3p hsa-miR-616* hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidSTRADA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STRADA
    Predesigned siRNA for gene silencing in human, mouse, rat STRADA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STRADA

    Clone
    Products:
         
    OriGene clones in human, mouse for STRADA (see all 32)
    OriGene ORF clones in mouse, rat for STRADA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): STRADA (NM_001003788)
    Sino Biological Human cDNA Clone for STRADA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRADA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRADA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STRADA
    Browse ESI BIO Cell Lines and PureStem Progenitors for STRADA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRADA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    STRAA_HUMAN, Q7RTN6: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12805220
    GO:0005737cytoplasm IDA12805220
    GO:0005829cytosol TAS--

    STRADA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for STRADA About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    PI3K Cascade0.87
    IRS-related events0.94
    Signaling by Insulin receptor0.80
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    PKB-mediated events0.41
    IRS-mediated signalling0.92
    mTOR signalling0.39
    2Signaling by GPCR
    Signal Transduction0.58
    3Translation Insulin regulation of translation
    mTOR signaling pathway0.34
    4LKB1 signaling events
    LKB1 signaling events
    5Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STRADA
        AMPK Enzyme Complex Pathway

    3 BioSystems Pathways for STRADA
        AMPK signaling
    Integrated Pancreatic Cancer Pathway
    LKB1 signaling events


    1 Reactome Pathway for STRADA
        Regulation of AMPK activity via LKB1


    1 Kegg Pathway  (Kegg details for STRADA):
        mTOR signaling pathway


    STRADA for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STRADA
    Interactions:

        GeneGlobe Interaction Network for STRADA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STRADA (Q7RTN61, 2, 3 ENSP000003366554) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAB39Q9Y3761, 2, 3, ENSP000002584184EBI-1109114,EBI-306905 MINT-8186774 MINT-8186758 MINT-8186742 I2D: score=3 STRING: ENSP00000258418
    STK11Q158311, 2, 3, ENSP000003248564EBI-1109114,EBI-306838 MINT-56666 MINT-56665 I2D: score=6 STRING: ENSP00000324856
    STK25O005063, ENSP000003257484I2D: score=1 STRING: ENSP00000325748
    SMAD4Q134853I2D: score=1 
    ACACBENSP000003670794STRING: ENSP00000367079
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468NOT protein phosphorylation IDA12805220
    GO:0006611protein export from nucleus IDA12805220
    GO:0007050cell cycle arrest TAS--
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0032147activation of protein kinase activity IDA12805220

    STRADA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STRADA (STRAA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for STRADA gene (6 alternative transcripts): 
    NM_001003786.2  NM_001003787.2  NM_001003788.2  NM_001165969.1  NM_001165970.1  NM_153335.5  

    Unigene Cluster for STRADA:

    STE20-related kinase adaptor alpha
    Hs.514402  [show with all ESTs]
    Unigene Representative Sequence: BC043641
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000245865(uc002jbr.3) ENST00000375840 ENST00000583085 ENST00000392950(uc002jbm.3 uc002jbn.3 uc010wpq.2 uc010wpr.2 uc002jbo.3 uc002jbp.3 uc010ddw.3)
    ENST00000336174 ENST00000582026 ENST00000447001 ENST00000582137 ENST00000580039
    ENST00000579340 ENST00000578008 ENST00000578801 ENST00000581243 ENST00000581505
    ENST00000577375 ENST00000580338 ENST00000579549 ENST00000582030
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STRADA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STRADA (see all 9):
    hsa-miR-3647-3p hsa-miR-4282 hsa-miR-432 hsa-miR-373* hsa-miR-375 hsa-miR-590-3p hsa-miR-616* hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidSTRADA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STRADA
    Predesigned siRNA for gene silencing in human, mouse, rat STRADA
    Clone
    Products:
         
    OriGene clones in human, mouse for STRADA (see all 32)
    OriGene ORF clones in mouse, rat for STRADA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): STRADA (NM_001003788)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRADA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRADA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STRADA
    OriGene qSTAR qPCR primer pairs in human, mouse for STRADA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STRADA
      QuantiTect SYBR Green Assays in human, mouse, rat STRADA
      QuantiFast Probe-based Assays in human, mouse, rat STRADA

    Additional mRNA sequence: 

    AF308302.1 AK074771.1 AK075005.1 AK092342.1 AK293160.1 AK301331.1 AL832407.1 AY290821.2 
    BC043641.1 

    Selected DOTS entries (see all 28):

    DT.86840052  DT.75122243  DT.100810170  DT.444727  DT.92428548  DT.100810162  DT.120925597  DT.65286068 
    DT.100832950  DT.100810163  DT.120925397  DT.120925514  DT.100810159  DT.120925556  DT.100810164  DT.95365775 
    DT.100810172  DT.120925562  DT.40127556  DT.91863466  DT.100739525  DT.120925503  DT.40309429  DT.92428543 

    15 AceView cDNA sequences:

    AL832407 NM_001003786 AY290821 CR593241 NM_153335 NM_001003788 CR601658 NM_001003787 
    AK074771 CR601269 AK075005 BK001542 AF308302 AK128173 BC043641 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    STRADA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCCTTCGC
    STRADA Expression
    About this image

    STRADA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STRADA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514402
        Custom PCR Arrays for STRADA
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for STRADA
    OriGene qSTAR qPCR primer pairs in human, mouse for STRADA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STRADA
    QuantiTect SYBR Green Assays in human, mouse, rat STRADA
    QuantiFast Probe-based Assays in human, mouse, rat STRADA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRADA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for STRADA gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Strada1 , 5 STE20-related kinase adaptor alpha1, 5 88.71(n)1
    95.13(a)1
      11 (68.89 cM)5
    721491  NM_001252448.11  NP_001239377.11 
     1061633305 
    chicken
    (Gallus gallus)
    Aves STRADA1 STE20-related kinase adaptor alpha 76.07(n)
    86.03(a)
      419957  NM_001012844.1  NP_001012862.1 
    lizard
    (Anolis carolinensis)
    Reptilia STRADA6
    STE20-related kinase adaptor alpha
    85(a)
    1 ↔ 1
    6(60809611-60826424)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377317842   -- 72.73(n)    137731784 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj99g052 wufj99g05 70.4(n)   334550  BC047830.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Stlk1 Ste20-like kinase 42.89(n)
    37.54(a)
      3355135  NM_001259209.2  NP_001246138.1 
    worm
    (Caenorhabditis elegans)
    Secernentea strd-11 strd-1 44.75(n)
    35.8(a)
      176526  NM_001027731.3  NP_001022902.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SKM16
    CLA46
    Member of the PAK family of serine/threonine prote...
    Cdc42p-activated signal transducing kinase of the ...
    13(a)
    10(a)
    many ↔ many
    many ↔ many
    XV(104326-106293) YOL113W
    XIV(68915-71443) YNL298W


    ENSEMBL Gene Tree for STRADA (if available)
    TreeFam Gene Tree for STRADA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for STRADA gene
    STRADB2  OXSR12  STK392  
    14 SIMAP similar genes for STRADA using alignment to 11 protein entries:     STRAA_HUMAN (see all proteins):
    STRADB    BRAF    STK25    OXSR1    STK4    STK3
    MST4    MAP4K5    MARK2    STK24    PAK3    PAK1
    MAP4K1    MINK1

    STRADA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STRADA
    PGOHUM00000245090


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for STRADA (see all 876)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs611515021,2
    C--61781336(+) AGAAC-/CAGAAC
            
    GAAGG
    6 -- cds10--------
    rs93034651,2
    C,A--61785251(+) acgccC/Tggcta 6 -- int10--------
    rs58214011,2
    C--61790360(+) AAAAA-/A/AA  
            
    GAAAA
    6 -- int11CSA 2
    rs1130312241,2
    C,F--61793648(+) GATGGG/AGTTTT 6 -- int11Minor allele frequency- A:0.50CSA 2
    rs1118462041,2
    F--61794863(+) TTAGAG/CAGACT 6 -- int11Minor allele frequency- C:0.50CSA 2
    rs1117258441,2
    C--61798002(+) GGCAGC/TGGGCA 6 -- int10--------
    rs1123550801,2
    C,F--61798817(+) CTCACG/ACCTGT 6 -- int11Minor allele frequency- A:0.50WA 2
    rs2000122231,2
    C--61801806(+) TTTTT-/TGAGAC 6 -- int10--------
    rs1130896801,2
    F--61802893(+) TTTTAG/ATAGAG 6 -- int11Minor allele frequency- A:0.50CSA 2
    rs58214021,2
    C--61805369(+) CTCAC-/GGGGGG 6 -- int10--------

    HapMap Linkage Disequilibrium report for STRADA (61780192 - 61819330 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for STRADA: --
    Human Gene Mutation Database (HGMD): STRADA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STRADA
    DNA2.0 Custom Variant and Variant Library Synthesis for STRADA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608626   
    OMIM disorders: 611087  
    UniProtKB/Swiss-Prot: STRAA_HUMAN, Q7RTN6
  • Note=A homozygous 7-kb deletion involving STRADA is a cause of a syndrome characterized by
    polyhydramnios, megalencephaly and symptomatic epilepsy

  • 12 diseases for STRADA:    
    About MalaCards
    polyhydramnios    polyhydramnios, megalencephaly, and symptomatic epilepsy    megalencephaly    epilepsy syndrome
    peutz-jeghers syndrome    breast cancer    gout    pancreatic cancer
    pancreatitis    multiple myeloma    myeloma    malaria

    2 diseases from the University of Copenhagen DISEASES database for STRADA:
    Peutz-Jeghers syndrome     Polyhydramnios

    STRADA for disorders           About GeneDecksing


    Export disorders for STRADA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for STRADA gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with STRADA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. (PubMed id 12805220)1, 2, 3, 9 Baas A.F.... Clevers H.C. (EMBO J. 2003)
    2. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. (PubMed id 19892943)1, 2 Zeqiraj E.... van Aalten D.M. (Science 2009)
    3. Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization. (PubMed id 17921699)1, 3 Marignani P.A....Resta N. (amp 2007)
    4. Crystal structure of MO25 alpha in complex with the C-terminus of the pseudo kinase STE20-related adaptor. (PubMed id 14730349)1, 2 Milburn C.C.... van Aalten D.M. (Nat. Struct. Mol. Biol. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. (PubMed id 14517248)1, 2 Boudeau J.... Alessi D.R. (EMBO J. 2003)
    7. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PubMed id 12747765)1, 2 Scanlan M.J.... Old L.J. (Cancer Immun. 2001)
    8. Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5. (PubMed id 17522105)2, 9 Puffenberger E.G.... Morton D.H. (Brain 2007)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PubMed id 24035498)1 Tan M.K....Harper J.W. (Mol. Cell 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 92335 HGNC: 30172 AceView: LYK5 Ensembl:ENSG00000266173 euGenes: HUgn92335
    ECgene: STRADA Kegg: 92335 H-InvDB: STRADA

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for STRADA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for STRADA gene:
    Search GeneIP for patents involving STRADA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for STRADA   OriGene RNAi products in human, mouse, rat for STRADA  
     OriGene qPCR primer pairs and template standards for STRADA   OriGene Protein Over-expression Lysate for STRADA  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for STRADA  
     OriGene qSTAR qPCR primer pairs in human, mouse for STRADA   OriGene Purified Protein for STRADA  
     OriGene ORF clones in mouse, rat for STRADA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for STRADA   OriGene Custom Protein Services for STRADA  

     
     
     Block miRNA regulation of human, mouse, rat STRADA using miScript Target Protectors SeqTarget long-range PCR primers for resequencing STRADA
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STRADA Predesigned siRNA for gene silencing in human, mouse, rat STRADA
     QuantiFast Probe-based Assays in human, mouse, rat STRADA QuantiTect SYBR Green Assays in human, mouse, rat STRADA
     Custom PCR Arrays for STRADA Search Chromatin IP Primers for STRADA
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STRADA  GeneGlobe Interaction Network for STRADA
     Regulatory tfbs in STRADA promoter
     GenScript Custom Purified and Recombinant Proteins Services for STRADA GenScript cDNA clones with any tag delivered in your preferred vector for STRADA
     GenScript Custom Assay Services for STRADA GenScript Custom overexpressing Cell Line Services for STRADA
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for STRADA (STRAA)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for STRADA
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     STRADA antibodies
     STRADA proteins
     STRADA lysates
     Antibodies for STRADA
     See all of Abcam's Antibodies, Kits and Proteins for STRADA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for STRADA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRADA
     SwitchGear 3'UTR luciferase reporter plasmids for STRADA
     SwitchGear Promoter luciferase reporter plasmids for STRADA
     ThermoFisher Antibody for STRADA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRADA
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STRADA
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STRADA
     LSBio Antibodies in human, mouse, rat for STRADA
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      STRADA gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4