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Aliases for STRADA Gene

Aliases for STRADA Gene

  • STE20-Related Kinase Adaptor Alpha 2 3
  • STRAD 3 4 6
  • LYK5 3 4 6
  • Serologically Defined Breast Cancer Antigen NY-BR-96 3 4
  • STE20-Like Pseudokinase 2 3
  • STRAD Alpha 3 4
  • STE20-Related Kinase Adapter Protein Alpha 3
  • STE20-Related Adapter Protein 4
  • Protein Kinase LYK5 3
  • NY-BR-96 3
  • PMSE 3
  • Stlk 3

External Ids for STRADA Gene

Summaries for STRADA Gene

Entrez Gene Summary for STRADA Gene

  • The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]

GeneCards Summary for STRADA Gene

STRADA (STE20-Related Kinase Adaptor Alpha) is a Protein Coding gene. Diseases associated with STRADA include polyhydramnios, megalencephaly, and symptomatic epilepsy and polyhydramnios. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include protein serine/threonine kinase activity and kinase binding. An important paralog of this gene is OXSR1.

UniProtKB/Swiss-Prot for STRADA Gene

  • Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

Gene Wiki entry for STRADA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRADA Gene

Genomics for STRADA Gene

Genomic Location for STRADA Gene

Start:
63,702,832 bp from pter
End:
63,741,970 bp from pter
Size:
39,139 bases
Orientation:
Minus strand

Genomic View for STRADA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STRADA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRADA Gene

Regulatory Elements for STRADA Gene

Proteins for STRADA Gene

  • Protein details for STRADA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTN6-STRAA_HUMAN
    Recommended name:
    STE20-related kinase adapter protein alpha
    Protein Accession:
    Q7RTN6
    Secondary Accessions:
    • B4DDE3
    • B4DW17
    • J3KTC9
    • Q5JPI2
    • Q7Z4K9
    • Q8NC31
    • Q8NCF1
    • Q9H272

    Protein attributes for STRADA Gene

    Size:
    431 amino acids
    Molecular mass:
    48369 Da
    Quaternary structure:
    • Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

    Three dimensional structures from OCA and Proteopedia for STRADA Gene

    Alternative splice isoforms for STRADA Gene

neXtProt entry for STRADA Gene

Proteomics data for STRADA Gene at MOPED

Post-translational modifications for STRADA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys239

No data available for DME Specific Peptides for STRADA Gene

Domains for STRADA Gene

Gene Families for STRADA Gene

Protein Domains for STRADA Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7RTN6

UniProtKB/Swiss-Prot:

STRAA_HUMAN
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.:
    • Q7RTN6
  • Contains 1 protein kinase domain.:
    • Q7RTN6
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.:
    • Q7RTN6
genes like me logo Genes that share domains with STRADA: view

Function for STRADA Gene

Molecular function for STRADA Gene

UniProtKB/Swiss-Prot Function: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

Gene Ontology (GO) - Molecular Function for STRADA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 NOT protein kinase activity IDA 12805220
GO:0004674 protein serine/threonine kinase activity --
GO:0004702 NOT receptor signaling protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 12805220
genes like me logo Genes that share ontologies with STRADA: view
genes like me logo Genes that share phenotypes with STRADA: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for STRADA Gene

Localization for STRADA Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRADA Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STRADA Gene COMPARTMENTS Subcellular localization image for STRADA gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for STRADA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12805220
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STRADA: view

Pathways for STRADA Gene

genes like me logo Genes that share pathways with STRADA: view

Gene Ontology (GO) - Biological Process for STRADA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 NOT mitotic cell cycle IBA --
GO:0006468 NOT protein phosphorylation IDA 12805220
GO:0006611 protein export from nucleus IDA 12805220
GO:0007050 cell cycle arrest TAS --
GO:0008286 insulin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with STRADA: view

Transcripts for STRADA Gene

Unigene Clusters for STRADA Gene

STE20-related kinase adaptor alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STRADA Gene

No ASD Table

Relevant External Links for STRADA Gene

GeneLoc Exon Structure for
STRADA
ECgene alternative splicing isoforms for
STRADA

Expression for STRADA Gene

mRNA expression in normal human tissues for STRADA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STRADA Gene

SOURCE GeneReport for Unigene cluster for STRADA Gene Hs.514402

genes like me logo Genes that share expressions with STRADA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STRADA Gene

Orthologs for STRADA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRADA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRADA 35
  • 96.2 (n)
  • 95.44 (a)
STRADA 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STRADA 35
  • 89.1 (n)
  • 95.44 (a)
STRADA 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STRADA 35
  • 92.81 (n)
  • 96.75 (a)
STRADA 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Strada 35
  • 88.71 (n)
  • 95.13 (a)
Strada 16
Strada 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STRADA 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRADA 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Strada 35
  • 88.17 (n)
  • 93.06 (a)
chicken
(Gallus gallus)
Aves STRADA 35
  • 76.07 (n)
  • 86.03 (a)
STRADA 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRADA 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia strada 35
  • 72.46 (n)
  • 78.63 (a)
zebrafish
(Danio rerio)
Actinopterygii strada 35
  • 69.88 (n)
  • 71.58 (a)
strada 36
  • 70 (a)
OneToOne
wufj99g05 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007805 35
  • 51.83 (n)
  • 40.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Stlk 35
  • 42.89 (n)
  • 37.54 (a)
Stlk 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea strd-1 35
  • 44.75 (n)
  • 35.8 (a)
strd-1 36
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLA4 36
  • 10 (a)
ManyToMany
SKM1 36
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for STRADA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRADA Gene

ENSEMBL:
Gene Tree for STRADA (if available)
TreeFam:
Gene Tree for STRADA (if available)

Paralogs for STRADA Gene

Paralogs for STRADA Gene

Pseudogenes.org Pseudogenes for STRADA Gene

genes like me logo Genes that share paralogs with STRADA: view

Variants for STRADA Gene

Sequence variations from dbSNP and Humsavar for STRADA Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs721575 -- 63,705,560(-) aagat(A/G)gctca intron-variant
rs1043127 -- 63,713,850(-) TTTTT(A/C)TGCCA intron-variant
rs1271517 -- 63,728,499(-) TGGTA(A/G)ACCTG intron-variant
rs1470697 -- 63,722,480(+) GGTCT(C/T)CAGAT intron-variant
rs1877318 -- 63,742,600(-) AAACT(C/T)CTCCC upstream-variant-2KB

Relevant External Links for STRADA Gene

HapMap Linkage Disequilibrium report
STRADA
Human Gene Mutation Database (HGMD)
STRADA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for STRADA Gene

Disorders for STRADA Gene

(1) OMIM Diseases for STRADA Gene (608626)

UniProtKB/Swiss-Prot

STRAA_HUMAN
  • Note=A homozygous 7-kb deletion involving STRADA is a cause of a syndrome characterized by polyhydramnios, megalencephaly and symptomatic epilepsy.

(2) University of Copenhagen DISEASES for STRADA Gene

genes like me logo Genes that share disorders with STRADA: view

Publications for STRADA Gene

  1. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. (PMID: 12805220) Baas A.F. … Clevers H.C. (EMBO J. 2003) 2 3 4 23
  2. Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5. (PMID: 17522105) Puffenberger E.G. … Morton D.H. (Brain 2007) 4 23
  3. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PMID: 12747765) Scanlan M.J. … Old L.J. (Cancer Immun. 2001) 3 4
  4. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. (PMID: 14517248) Boudeau J. … Alessi D.R. (EMBO J. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for STRADA Gene

Sources for STRADA Gene

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