STRA8 Gene
protein-coding GIFtS : 43
GCID: GC07 P134916
stimulated by retinoic acid 8 (Previous names: stimulated by retinoic acid gene 8 homolog (mouse), stimulated... )
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Aliasesfor STRA8 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Stimulated By Retinoic Acid 8 1 2 Stimulated By Retinoic Acid 8 Homolog (Mouse)1 Stimulated By Retinoic Acid Gene 8 Homolog (Mouse)1 Stimulated By Retinoic Acid 8 Homolog2 Stimulated By Retinoic Acid Gene 8 Homolog2 Stimulated By Retinoic Acid Gene 8 Protein Homolog2
Export aliases for STRA8 gene to outside databases Previous GC identifers: GC07P134568 GC07P129219
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Summariesfor STRA8 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for STRA8 : This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. (provided by RefSeq, Nov 2010) UniProtKB/Swiss-Prot: STRA8_HUMAN, Q7Z7C7 Function : Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germcells, required for premeiotic DNA replication and subsequent events in meiotic prophase (By similarity)
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Genomic Viewsfor STRA8 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the STRA8 gene promoter: NF-YB GATA-3 NF-YA Lmo2 CP1C CP1A NF-Y CBF-C GATA-1 GATA-2 Other transcription factors Search SABiosciences Chromatin IP Primers for STRA8 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STRA8
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7q33 Ensembl cytogenetic band: 7q33 HGNC cytogenetic band: 7q33 STRA8 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07P134916: view genomic region
(about GC identifiers )
Start:
134,916,731 bp from pter
End:
134,943,244 bp from pter
Size:
26,514 bases
Orientation:
plus strand
1 alternative location : Chr 7+,CRA_TCAG 134,261,076-134,287,597
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Proteinsfor STRA8 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: STRA8_HUMAN, Q7Z7C7 (See
protein sequence )Recommended Name: Stimulated by retinoic acid gene 8 protein homolog Size : 330 amino acids; 36908 Da
Subcellular location : Cytoplasm (By similarity)Explore the universe of human proteins at neXtProt for STRA8: NX_Q7Z7C7 Post-translational modifications:
Phosphorylated (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q7Z7C7 STRA8 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_872295.1 ENSEMBL proteins: ENSP00000275764 Human Recombinant Protein Products for STRA8: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005737 cytoplasm
IEA --
STRA8 for ontologies About GeneDecksing STRA8 Antibody Products: Assay Products for STRA8:
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Protein
Domains / Familiesfor STRA8 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
STRA8 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q7Z7C7 ProtoNet protein and cluster: Q7Z7C7
1 Blocks protein family : IPB001092 Basic helix-loop-helix dimerization domain bHLH
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Functionfor STRA8 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: STRA8_HUMAN, Q7Z7C7 Function : Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germcells, required for premeiotic DNA replication and subsequent events in meiotic prophase (By similarity)
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0046983 protein dimerization activity
IEA --
STRA8 for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for STRA8 : 2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Stra8) :
STRA8 for phenotypes About GeneDecksing Animal Models: Mouse knock-outs for STRA8: Stra8 tm1.1Nbg Stra8 tm1Dcp Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for STRA8 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for STRA8OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: STRA8 (NM_182489 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STRA8 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat STRA8
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRA8
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Pathways & Interactionsfor STRA8 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STRA8 Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13 ): About this table
STRA8 for ontologies About GeneDecksing
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Drugs & Compoundsfor STRA8 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for STRA8 Search CenterWatch for drugs/clinical trials and news about STRA8
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Transcriptsfor STRA8 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for STRA8 gene: NM_182489.1 Unigene Cluster for STRA8:
Stimulated by retinoic acid 8 Hs.592279 Unigene Representative Sequence: AF513502 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000275764 (uc011kpx.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for STRA8 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for STRA8OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: STRA8 (NM_182489 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STRA8 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat STRA8
Additional cDNA sequence: AF513502.1
1 DOTS entry : DT.100700752
2 AceView cDNA sequences :
NM_182489 AF513502 GeneLoc Exon Structure
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Expression for STRA8 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section STRA8 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTGCAGTGCAAbout this image STRA8 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See STRA8 Protein Expression from SPIRE MOPED and PaxDB SOURCE GeneReport for Unigene cluster: Hs.592279 UniProtKB/Swiss-Prot: STRA8_HUMAN, Q7Z7C7 Tissue specificity : Expressed specifically in testis SABiosciences Custom PCR Arrays for STRA8 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for STRA8Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat STRA8 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat STRA8 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat STRA8 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRA8
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Orthologsfor STRA8 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for STRA8 gene from 3/9 species (see all 9 ) About this table
ENSEMBL Gene Tree for STRA8 (if available)TreeFam Gene Tree for STRA8 (if available)
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Paralogsfor STRA8 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor STRA8 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 7 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for STRA8 (134916731 - 134943244 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for STRA8: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing STRA8
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Disorders
/ Diseasesfor STRA8 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
STRA8 for disorders About GeneDecksing
OMIM gene information: 609987
OMIM disorders : --5 diseases for STRA8 : About MalaCards male infertility teratoma teratocarcinoma infertility azoospermia 2 diseases from the University of Copenhagen DISEASES database for STRA8 :Male infertility Spermatocytoma Human Genome Epidemiology (HuGE) Navigator: STRA8 (1 document)Export disorders for STRA8 gene to outside databases
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Publicationsfor STRA8 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for STRA8 gene integrated from 9 sources : (articles sorted by number of sources associating them with STRA8) Utopia : connect your pdf to the dynamic world of online information
Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8. (PubMed id 12489526) 1 , 2 , 3 Miyamoto T.... Ishikawa M. (2002) Human chromosome 7: DNA sequence and biology. (PubMed id 12690205) 1 , 2 Scherer S.W.... Tsui L.-C. (2003) Meiosis initiation in the human ovary requires intrin sic retinoic acid synthesis. (PubMed id 20670969) 1 Le Bouffant R....Livera G. (2010) Evaluation of 172 candidate polymorphisms for associa tion with oligozoospermia or azoospermia in a large cohort of men of European d escent. (PubMed id 20378615) 1 Aston K.I....Carrell D.T. (2010) Xeno-free culture of human spermatogonial stem cells supported by human embryonic stem cell-derived fibroblast-like cells. (PubMed id 19734913) 1 Chen B....Wang Z. (2009) [Genetics and male infertility] (PubMed id 20088251) 1 Stouffs K....Lissens W. (2009) Global gene expression in the human fetal testis and ovary. (PubMed id 19369649) 1 Houmard B....Griswold M. (2009) Stra8 and its inducer, retinoic acid, regulate meioti c initiation in both spermatogenesis and oogenesis in mice. (PubMed id 18799751) 1 Anderson E.L....Page D.C. (2008) Exploration of human ORFeome: high-throughput prepara tion of ORF clones and efficient characterization of their protein products. (PubMed id 18316326) 1 Nagase T....Ohara O. (2008)
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External Searches for STRA8 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing STRA8 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing STRA8 gene
(According to HUGE )
About This Section --
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Specialized Databases showing STRA8 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for STRA8 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for STRA8 gene: Search GeneIP for patents involving STRA8 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor STRA8 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for STRA8 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for STRA8 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for STRA8 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for STRA8 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for STRA8 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for STRA8 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for STRA8 OriGene Custom Protein Services for STRA8 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STRA8 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing STRA8 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STRA8 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat STRA8 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat STRA8 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat STRA8
Search Tocris compounds for STRA8
STRA8 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRA8
Search ThermoFisher Antibodies for STRA8
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat STRA8
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Aliases for STRA8
Databases for STRA8
Disorders / Diseases for STRA8
Domains / Families for STRA8
Drugs / Compounds for STRA8
Expression for STRA8
Function for STRA8
Genomic Views for STRA8
Intellectual Property for STRA8
Orthologs for STRA8
Paralogs for STRA8
Pathways / Interactions for STRA8
Products for STRA8
Proteins for STRA8
Publications for STRA8
Search Box for STRA8
Summaries for STRA8
Transcripts for STRA8
Variants for STRA8
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