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Aliases for STRA8 Gene

Aliases for STRA8 Gene

  • Stimulated By Retinoic Acid 8 2 3 5
  • Stimulated By Retinoic Acid Gene 8 Homolog (Mouse) 2
  • Stimulated By Retinoic Acid 8 Homolog (Mouse) 2

External Ids for STRA8 Gene

Previous GeneCards Identifiers for STRA8 Gene

  • GC07P134568
  • GC07P134916
  • GC07P129219

Summaries for STRA8 Gene

Entrez Gene Summary for STRA8 Gene

  • This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]

GeneCards Summary for STRA8 Gene

STRA8 (Stimulated By Retinoic Acid 8) is a Protein Coding gene. Diseases associated with STRA8 include Male Reproductive System Disease and Reproductive System Disease. GO annotations related to this gene include protein dimerization activity.

UniProtKB/Swiss-Prot for STRA8 Gene

  • Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. Can associate with DNA (possibly in an indirect manner), and in vitro can activate DNA transcription (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRA8 Gene

Genomics for STRA8 Gene

Regulatory Elements for STRA8 Gene

Enhancers for STRA8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F135253 1.4 FANTOM5 Ensembl ENCODE 12.1 +22.5 22510 2.2 JUND MCM3 JUN SIN3A NFE2 ZIC2 SPI1 TCF7L2 NFE2L2 WDR91 STRA8 ENSG00000231794 TMEM140 CNOT4 GC07P135285
GH07F135260 0.7 Ensembl ENCODE 11.8 +29.4 29381 1.1 PKNOX1 INSM2 FEZF1 ZNF366 EGR2 OVOL3 CEBPB ZEB2 ZNF488 TSHZ1 STRA8 WDR91 ENSG00000231794 GC07P135285
GH07F135206 0.7 ENCODE 11.1 -24.9 -24902 1.6 PKNOX1 ATF1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ENSG00000231794 WDR91 STRA8 C7orf49 TMEM140 AGBL3 MIR6509
GH07F135203 1.1 Ensembl ENCODE 11 -27.3 -27296 3.1 ZSCAN5A SREBF2 INSM2 ZIC2 ZEB1 ZNF324 ZNF366 ZBTB48 ZNF239 PRDM10 ENSG00000231794 STRA8 WDR91 AGBL3 C7orf49 MIR6509
GH07F134830 0.5 FANTOM5 5.3 -401.8 -401770 0.3 CTCF ARNT SIN3A BMI1 RAD21 GATA3 GATA2 ZNF366 SCRT2 SMC3 STRA8 GC07M134784 PIR46779
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around STRA8 on UCSC Golden Path with GeneCards custom track

Genomic Location for STRA8 Gene

Chromosome:
7
Start:
135,231,979 bp from pter
End:
135,258,661 bp from pter
Size:
26,683 bases
Orientation:
Plus strand

Genomic View for STRA8 Gene

Genes around STRA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRA8 Gene

Proteins for STRA8 Gene

  • Protein details for STRA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7C7-STRA8_HUMAN
    Recommended name:
    Stimulated by retinoic acid gene 8 protein homolog
    Protein Accession:
    Q7Z7C7

    Protein attributes for STRA8 Gene

    Size:
    330 amino acids
    Molecular mass:
    36908 Da
    Quaternary structure:
    • Interacts with XPO1.

neXtProt entry for STRA8 Gene

Post-translational modifications for STRA8 Gene

Other Protein References for STRA8 Gene

No data available for DME Specific Peptides for STRA8 Gene

Domains & Families for STRA8 Gene

Protein Domains for STRA8 Gene

Suggested Antigen Peptide Sequences for STRA8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STRA8: view

No data available for Gene Families and UniProtKB/Swiss-Prot for STRA8 Gene

Function for STRA8 Gene

Molecular function for STRA8 Gene

UniProtKB/Swiss-Prot Function:
Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. Can associate with DNA (possibly in an indirect manner), and in vitro can activate DNA transcription (By similarity).

Gene Ontology (GO) - Molecular Function for STRA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with STRA8: view
genes like me logo Genes that share phenotypes with STRA8: view

Animal Models for STRA8 Gene

MGI Knock Outs for STRA8:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for STRA8 Gene

Localization for STRA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRA8 Gene

Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. Nuclear export is XPO1-dependent. {ECO:0000250 UniProtKB:P70278}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STRA8 Gene COMPARTMENTS Subcellular localization image for STRA8 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for STRA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 22899867
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with STRA8: view

Pathways & Interactions for STRA8 Gene

SuperPathways for STRA8 Gene

No Data Available

Interacting Proteins for STRA8 Gene

Gene Ontology (GO) - Biological Process for STRA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0006260 DNA replication IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007066 female meiosis sister chromatid cohesion IEA --
genes like me logo Genes that share ontologies with STRA8: view

No data available for Pathways by source and SIGNOR curated interactions for STRA8 Gene

Transcripts for STRA8 Gene

mRNA/cDNA for STRA8 Gene

(5) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRA8 Gene

No ASD Table

Relevant External Links for STRA8 Gene

GeneLoc Exon Structure for
STRA8
ECgene alternative splicing isoforms for
STRA8

Expression for STRA8 Gene

mRNA expression in normal human tissues for STRA8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STRA8 Gene

This gene is overexpressed in Testis (x15.0), Kidney - Cortex (x12.1), and Skin - Not Sun Exposed (Suprapubic) (x4.6).

Protein differential expression in normal tissues from HIPED for STRA8 Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STRA8 Gene



Protein tissue co-expression partners for STRA8 Gene

NURSA nuclear receptor signaling pathways regulating expression of STRA8 Gene:

STRA8

SOURCE GeneReport for Unigene cluster for STRA8 Gene:

Hs.592279

mRNA Expression by UniProt/SwissProt for STRA8 Gene:

Q7Z7C7-STRA8_HUMAN
Tissue specificity: Expressed specifically in testis and fetal ovaries.
genes like me logo Genes that share expression patterns with STRA8: view

Primer Products

Orthologs for STRA8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STRA8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRA8 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia STRA8 34 35
  • 81.76 (n)
rat
(Rattus norvegicus)
Mammalia Stra8 34
  • 79.98 (n)
cow
(Bos Taurus)
Mammalia STRA8 34 35
  • 79.45 (n)
mouse
(Mus musculus)
Mammalia Stra8 34 16 35
  • 79.08 (n)
oppossum
(Monodelphis domestica)
Mammalia STRA8 35
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRA8 35
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves STRA8 34 35
  • 65.9 (n)
lizard
(Anolis carolinensis)
Reptilia STRA8 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stra8 34
  • 52.12 (n)
Species where no ortholog for STRA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for STRA8 Gene

ENSEMBL:
Gene Tree for STRA8 (if available)
TreeFam:
Gene Tree for STRA8 (if available)

Paralogs for STRA8 Gene

No data available for Paralogs for STRA8 Gene

Variants for STRA8 Gene

Sequence variations from dbSNP and Humsavar for STRA8 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1019619 -- 135,258,018(+) GCACG(C/G)TGTCT intron-variant
rs10225934 -- 135,239,000(+) TTCCT(G/T)CCCTG intron-variant
rs10230595 -- 135,240,636(+) AGGCC(C/T)GCCAC reference, missense
rs10231873 -- 135,235,733(+) caccg(C/T)gccca intron-variant
rs10242159 -- 135,239,753(+) TCAGA(C/T)GTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STRA8 Gene

Variant ID Type Subtype PubMed ID
esv2676296 CNV deletion 23128226
esv3615116 CNV loss 21293372
nsv1075059 CNV deletion 25765185
nsv523974 CNV loss 19592680

Variation tolerance for STRA8 Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STRA8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STRA8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRA8 Gene

Disorders for STRA8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for STRA8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
male reproductive system disease
  • genital diseases, male
reproductive system disease
  • genital system disease
- elite association - COSMIC cancer census association via MalaCards
Search STRA8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STRA8

Genetic Association Database (GAD)
STRA8
Human Genome Epidemiology (HuGE) Navigator
STRA8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STRA8
genes like me logo Genes that share disorders with STRA8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STRA8 Gene

Publications for STRA8 Gene

  1. Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8. (PMID: 12489526) Miyamoto T. … Ishikawa M. (J. Assist. Reprod. Genet. 2002) 2 3 4 64
  2. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston K.I. … Carrell D.T. (Hum. Reprod. 2010) 3 46 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  4. Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts. (PMID: 26742488) Abby E. … Livera G. (Nat Commun 2016) 4 64
  5. Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population. (PMID: 23320086) Lu C. … Wang X. (PLoS ONE 2013) 3 64

Products for STRA8 Gene

Sources for STRA8 Gene

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