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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STRA8 Gene

protein-coding   GIFtS: 44
GCID: GC07P134916

Stimulated By Retinoic Acid 8

(Previous names: stimulated by retinoic acid gene 8 homolog (mouse), stimulated...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Stimulated By Retinoic Acid 81 2
Stimulated By Retinoic Acid 8 Homolog (Mouse)1
Stimulated By Retinoic Acid Gene 8 Homolog (Mouse)1
Stimulated By Retinoic Acid 8 Homolog2
Stimulated By Retinoic Acid Gene 8 Homolog2
Stimulated By Retinoic Acid Gene 8 Protein Homolog2

External Ids:    HGNC: 306531   Entrez Gene: 3466732   Ensembl: ENSG000001468577   OMIM: 6099875   UniProtKB: Q7Z7C73   

Export aliases for STRA8 gene to outside databases

Previous GC identifers: GC07P134568 GC07P129219


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STRA8 Gene:
This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved
in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between
the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought
that this gene may play a role in spermatogenesis in humans. (provided by RefSeq, Nov 2010)

GeneCards Summary for STRA8 Gene: 
STRA8 (stimulated by retinoic acid 8) is a protein-coding gene. Diseases associated with STRA8 include spermatocytoma, and male infertility. GO annotations related to this gene include protein dimerization activity.

UniProtKB/Swiss-Prot: STRA8_HUMAN, Q7Z7C7
Function: Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female
germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STRA8 gene promoter:
         NF-YB   GATA-3   NF-YA   Lmo2   CP1C   CP1A   NF-Y   CBF-C   GATA-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTRA8 promoter sequence
   Search SABiosciences Chromatin IP Primers for STRA8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STRA8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q33

STRA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STRA8 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P134916:  view genomic region     (about GC identifiers)

Start:
134,916,731 bp from pter      End:
134,943,244 bp from pter
Size:
26,514 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 134,261,076-134,287,597     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STRA8_HUMAN, Q7Z7C7 (See protein sequence)
Recommended Name: Stimulated by retinoic acid gene 8 protein homolog  
Size: 330 amino acids; 36908 Da
Subcellular location: Cytoplasm (By similarity)

Explore the universe of human proteins at neXtProt for STRA8: NX_Q7Z7C7

Explore proteomics data for STRA8 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z7C7

  • STRA8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STRA8 Protein Expression
    REFSEQ proteins: NP_872295.1  
    ENSEMBL proteins: 
     ENSP00000275764  

    Human Recombinant Protein Products for STRA8: 
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    Cloud-Clone Corp. Proteins for STRA8 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    STRA8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z7C7

    ProtoNet protein and cluster: Q7Z7C7

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH


    STRA8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STRA8_HUMAN, Q7Z7C7
    Function: Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female
    germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0046983protein dimerization activity IEA--
         
    STRA8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for STRA8:
     Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Stra8):
     endocrine/exocrine gland  reproductive system 

    STRA8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for STRA8: Stra8tm1.1Nbg Stra8tm1Dcp

       inGenious Targeting Laboratory - Custom generated mouse model solutions for STRA8 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STRA8

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IEA--
    GO:0006260DNA replication IEA--
    GO:0007066female meiosis sister chromatid cohesion IEA--
    GO:0007129synapsis IEA--
    GO:0007131reciprocal meiotic recombination IEA--

    STRA8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STRA8

    Search CenterWatch for drugs/clinical trials and news about STRA8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STRA8 gene: 
    NM_182489.1  

    Unigene Cluster for STRA8:

    Stimulated by retinoic acid 8
    Hs.592279
    Unigene Representative Sequence: AF513502
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000275764(uc011kpx.2)
    miRNA
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRA8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRA8
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                         Customized lentivirus expression plasmids for stable overexpression of STRA8 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STRA8

    Additional mRNA sequence: AF513502.1 

    1 DOTS entry:

    DT.100700752 

    2 AceView cDNA sequences:

    NM_182489 AF513502 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STRA8 expression in normal human tissues (normalized intensities)      STRA8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCAGTGCA
    STRA8 Expression
    About this image


    STRA8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
     
     Inner Cell Mass (Early Embryonic Tissues)
             ES-J1
     
     Gonad
             XX Germ Cells Ovigerous Cord
     
     Spleen (Hematopoietic System)
             Spleen
     
     Testis (Reproductive System)

    See STRA8 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.592279

    UniProtKB/Swiss-Prot: STRA8_HUMAN, Q7Z7C7
    Tissue specificity: Expressed specifically in testis

        SABiosciences Custom PCR Arrays for STRA8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRA8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for STRA8 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stra81 , 5 stimulated by retinoic acid gene 81, 5 75.83(n)1
    64.95(a)1
      6 (15.20 cM)5
    208991  NM_009292.11  NP_033318.11 
     349201635 
    chicken
    (Gallus gallus)
    Aves STRA81 stimulated by retinoic acid gene 8 homolog (mouse) 65.9(n)
    54.59(a)
      417938  XM_416179.3  XP_416179.3 
    lizard
    (Anolis carolinensis)
    Reptilia STRA86
    stimulated by retinoic acid 8
    44(a)
    1 ↔ 1
    5(27969423-27998089)


    ENSEMBL Gene Tree for STRA8 (if available)
    TreeFam Gene Tree for STRA8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/569 SNPs in STRA8 are shown (see all 569)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394995241,2
    --134914776(+) CTCATA/CATCGG 1 -- us2k10--------
    rs102691481,2
    C,F,H--134914808(+) TGATCC/GTACGT 1 -- us2k120Minor allele frequency- G:0.13NS EA NA WA 2660
    rs1496927201,2
    --134914812(+) CCTACA/GTCCTT 1 -- us2k10--------
    rs1831416351,2
    --134914821(+) TTGAAA/CTATTA 1 -- us2k10--------
    rs171683191,2
    C,F,H--134914953(+) AAAAGA/GAGTGA 1 -- us2k1 trp319Minor allele frequency- G:0.11NA NS EA 2176
    rs1880758521,2
    --134915095(+) ACAGAC/TGACGA 1 -- us2k10--------
    rs2926271,2
    C,F,O,A,H--134915164(+) AGCCCA/GTTTGA 1 -- us2k130Minor allele frequency- G:0.08MN NA NS EA WA CSA 2494
    rs1929709811,2
    --134915280(+) CTCAAA/GCACAA 1 -- us2k10--------
    rs1484130751,2
    C--134915359(+) CCCTAC/TAGCAG 1 -- us2k10--------
    rs1842662731,2
    --134915361(+) CTATAA/GCAGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for STRA8 (134916731 - 134943244 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STRA8:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676296CNV Deletion23128226
    nsv523974CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for STRA8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609987    OMIM disorders: --

    6 diseases for STRA8:    About MalaCards
    spermatocytoma    male infertility    teratoma    teratocarcinoma
    azoospermia    infertility

    2 diseases from the University of Copenhagen DISEASES database for STRA8:
    Male infertility     Infertility

    STRA8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): STRA8
    Human Genome Epidemiology (HuGE) Navigator: STRA8 (1 document)

    Export disorders for STRA8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STRA8 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with STRA8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8. (PubMed id 12489526)1, 2, 3 Miyamoto T.... Ishikawa M. (2002)
    2. Evaluation of 172 candidate polymorphisms for associa tion with oligozoospermia or azoospermia in a large cohort of men of European d escent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (2010)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    4. Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population. (PubMed id 23320086)1 Lu C....Wang X. (2013)
    5. Meiosis initiation in the human ovary requires intrin sic retinoic acid synthesis. (PubMed id 20670969)1 Le Bouffant R....Livera G. (2010)
    6. Xeno-free culture of human spermatogonial stem cells supported by human embryonic stem cell-derived fibroblast-like cells. (PubMed id 19734913)1 Chen B....Wang Z. (2009)
    7. [Genetics and male infertility] (PubMed id 20088251)1 Stouffs K....Lissens W. (2009)
    8. Global gene expression in the human fetal testis and ovary. (PubMed id 19369649)1 Houmard B....Griswold M. (2009)
    9. Stra8 and its inducer, retinoic acid, regulate meioti c initiation in both spermatogenesis and oogenesis in mice. (PubMed id 18799751)1 Anderson E.L....Page D.C. (2008)
    10. Exploration of human ORFeome: high-throughput prepara tion of ORF clones and efficient characterization of their protein products. (PubMed id 18316326)1 Nagase T....Ohara O. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 346673 HGNC: 30653 AceView: LOC346673 Ensembl:ENSG00000146857 euGenes: HUgn346673
    ECgene: STRA8 H-InvDB: STRA8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STRA8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STRA8 gene:
    Search GeneIP for patents involving STRA8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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