Aliases for STRA6 Gene
External Ids for STRA6 Gene
The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
GeneCards Summary for STRA6 Gene
STRA6 (Stimulated By Retinoic Acid 6) is a Protein Coding gene. Diseases associated with STRA6 include diaphragmatic eventration and microphthalmia, syndromic 9. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include receptor activity and vitamin transporter activity.
UniProtKB/Swiss-Prot for STRA6 Gene
May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex (By similarity).