Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STRA6 Gene

protein-coding   GIFtS: 54
GCID: GC15M074471

Stimulated By Retinoic Acid 6

(Previous names: stimulated by retinoic acid gene 6 homolog (mouse), stimulated...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Stimulated By Retinoic Acid 61 2     MCOPCB82
MCOPS92 5     Stimulated By Retinoic Acid 6 Homolog2
Stimulated By Retinoic Acid 6 Homolog (Mouse)1     Stimulated By Retinoic Acid Gene 6 Homolog2
Stimulated By Retinoic Acid Gene 6 Homolog (Mouse)1     Stimulated By Retinoic Acid Gene 6 Protein Homolog2

External Ids:    HGNC: 306501   Entrez Gene: 642202   Ensembl: ENSG000001378687   OMIM: 6107455   UniProtKB: Q9BX793   

Export aliases for STRA6 gene to outside databases

Previous GC identifers: GC15M072260 GC15M051265


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STRA6 Gene:
The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein
acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the
complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia
type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene.
(provided by RefSeq, Dec 2008)

GeneCards Summary for STRA6 Gene: 
STRA6 (stimulated by retinoic acid 6) is a protein-coding gene. Diseases associated with STRA6 include diaphragmatic eventration, and microphthalmia syndromic 9, and among its related super-pathways are Retinoid metabolism and transport and Signaling by GPCR. GO annotations related to this gene include vitamin transporter activity and receptor activity.

UniProtKB/Swiss-Prot: STRA6_HUMAN, Q9BX79
Function: May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein
(RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be
metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases
cellular retinol uptake from the retinol-RBP complex (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STRA6 gene promoter:
         IRF-2   CP2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   HNF-4alpha2   POU3F2   HNF-4alpha1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTRA6 promoter sequence
   Search SABiosciences Chromatin IP Primers for STRA6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STRA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24.1

STRA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STRA6 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M074471:  view genomic region     (about GC identifiers)

Start:
74,471,807 bp from pter      End:
74,504,608 bp from pter
Size:
32,802 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STRA6_HUMAN, Q9BX79 (See protein sequence)
Recommended Name: Stimulated by retinoic acid gene 6 protein homolog  
Size: 667 amino acids; 73503 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAB14122.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAH13848.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAD97655.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K7F1 B7Z5M9 B7Z862 D3DW54 F5GYI8 I3L1G8 Q6PJF8 Q71RB9 Q7L9G1 Q7Z3U9
Q8TB21 Q9BX78 Q9H9U8
Alternative splicing: 6 isoforms:  Q9BX79-1   Q9BX79-2   Q9BX79-3   Q9BX79-4   Q9BX79-5   Q9BX79-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STRA6: NX_Q9BX79

Explore proteomics data for STRA6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BX79

  • STRA6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STRA6 Protein Expression
    REFSEQ proteins (8 alternative transcripts): 
    NP_001136089.1  NP_001136090.1  NP_001136091.1  NP_001136092.1  NP_001185969.1  NP_001185970.1  NP_001185971.1  NP_071764.3  

    ENSEMBL proteins: 
     ENSP00000378537   ENSP00000413012   ENSP00000326085   ENSP00000410221   ENSP00000400403  
     ENSP00000440238   ENSP00000456609   ENSP00000458827   ENSP00000459546   ENSP00000461799  
     ENSP00000407176   ENSP00000458204   ENSP00000458734  
    Reactome Protein details: Q9BX79
    Human Recombinant Protein Products for STRA6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for STRA6
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for STRA6
    GenScript Custom Purified and Recombinant Proteins Services for STRA6
    Novus Biologicals STRA6 Protein
    Novus Biologicals STRA6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STRA6 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0043234protein complex IDA--

    STRA6 for ontologies           About GeneDecksing



    STRA6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for STRA6
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for STRA6
    GenScript Custom Superior Antibodies Services for STRA6
    Novus Biologicals STRA6 Antibodies
    Abcam antibodies for STRA6
    Cloud-Clone Corp. Antibodies for STRA6 
    ThermoFisher Antibody for STRA6
    LSBio Antibodies in human, mouse, rat for STRA6 

    Assay Products for STRA6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STRA6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STRA6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STRA6 
    Cloud-Clone Corp. CLIAs for STRA6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026612 STRA6

    Graphical View of Domain Structure for InterPro Entry Q9BX79

    ProtoNet protein and cluster: Q9BX79


    STRA6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STRA6_HUMAN, Q9BX79
    Function: May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein
    (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be
    metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases
    cellular retinol uptake from the retinol-RBP complex (By similarity)
    Induction: Up-regulated in the colorectal cancer cell line WiDr by the administration of retinoic acid and in
    tumors with frequent defects in Wnt-1 signaling

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0051183vitamin transporter activity IEA--
         
    STRA6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for STRA6:
     Decreased viability with pacli  Large cells 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Stra6):
     growth/size  homeostasis/metabolism  nervous system  vision/eye 

    STRA6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Stra6tm1Nbg for STRA6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for STRA6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STRA6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STRA6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STRA6 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STRA6
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate STRA6:
    hsa-miR-1287 hsa-miR-1231 hsa-miR-544b hsa-miR-149 hsa-miR-130b* hsa-miR-323b-5p
    SwitchGear 3'UTR luciferase reporter plasmidSTRA6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STRA6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STRA6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STRA6
    Sirion Biotech Customized adenovirus for overexpression of STRA6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for STRA6 (see all 34)
    OriGene ORF clones in mouse, rat for STRA6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): STRA6 (NM_022369)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRA6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRA6
    Sirion Biotech Customized lentivirus for stable overexpression of STRA6 
                         Customized lentivirus expression plasmids for stable overexpression of STRA6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STRA6
    Search LifeMap BioReagents cell lines for STRA6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRA6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STRA6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Visual phototransduction
    Visual phototransduction0.48
    Diseases associated with visual transduction0.47
    2Signaling by GPCR
    Signal Transduction0.55
    3the visual cycle I (vertebrates)
    The canonical retinoid cycle in rods (twilight vision)0.50
    4The retinoid cycle in cones (daylight vision)
    Retinoid cycle disease events0.36
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/6        Reactome Pathways for STRA6 (see all 6)
        Diseases associated with visual transduction
    Retinoid cycle disease events
    Signal Transduction
    The canonical retinoid cycle in rods (twilight vision)
    Visual phototransduction



    STRA6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STRA6

    Gene Ontology (GO): 5/38 biological process terms (GO ID links to tree view) (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0001568blood vessel development IMP17273977
    GO:0001822kidney development IMP17273977
    GO:0003184pulmonary valve morphogenesis IMP17273977
    GO:0003281ventricular septum development IMP17273977

    STRA6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STRA6

    Search CenterWatch for drugs/clinical trials and news about STRA6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STRA6 gene (8 alternative transcripts): 
    NM_001142617.1  NM_001142618.1  NM_001142619.1  NM_001142620.1  NM_001199040.1  NM_001199041.1  NM_001199042.1  NM_022369.3  

    Unigene Cluster for STRA6:

    Stimulated by retinoic acid 6
    Hs.24553  [show with all ESTs]
    Unigene Representative Sequence: NM_001199042
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000395105(uc010ulh.2 uc002axk.3 uc002axj.3) ENST00000423167
    ENST00000323940(uc002axm.3 uc002axn.3) ENST00000449139(uc021sqg.1 uc010uli.2)
    ENST00000416286 ENST00000545137(uc002axi.3) ENST00000574439(uc002axl.3 uc010bji.3)
    ENST00000535552 ENST00000563965 ENST00000574278 ENST00000572785 ENST00000575272
    ENST00000569936(uc010bjj.1) ENST00000572975 ENST00000432245(uc010bjk.3)
    ENST00000573724 ENST00000573456 ENST00000573214
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STRA6
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate STRA6:
    hsa-miR-1287 hsa-miR-1231 hsa-miR-544b hsa-miR-149 hsa-miR-130b* hsa-miR-323b-5p
    SwitchGear 3'UTR luciferase reporter plasmidSTRA6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STRA6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STRA6
    Clone
    Products:
         
    OriGene clones in human, mouse for STRA6 (see all 34)
    OriGene ORF clones in mouse, rat for STRA6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): STRA6 (NM_022369)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRA6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRA6
    Sirion Biotech Customized lentivirus for stable overexpression of STRA6 
                         Customized lentivirus expression plasmids for stable overexpression of STRA6 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STRA6
    OriGene qSTAR qPCR primer pairs in human, mouse for STRA6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STRA6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STRA6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STRA6

    Additional mRNA sequence: 

    AF352728.1 AF352729.1 AF370419.2 AK022603.1 AK056125.1 AK091152.1 AK092227.1 AK291966.1 
    AK298921.1 AK298928.1 AK299191.1 AK302932.1 AK309676.1 AK310878.1 AY358748.1 AY359089.1 
    BC015881.2 BC025256.1 BX537413.1 

    23 DOTS entries:

    DT.101982463  DT.208763  DT.100716853  DT.97841594  DT.100786351  DT.121072519  DT.75127321  DT.100021046 
    DT.121072545  DT.91840944  DT.91819609  DT.121072550  DT.95270686  DT.100694046  DT.100768898  DT.102824834 
    DT.102824835  DT.121072511  DT.121072530  DT.91687192  DT.91869057  DT.100676509  DT.91957371 

    24/120 AceView cDNA sequences (see all 120):

    BQ919038 BQ430926 AY359089 AK092227 AF352728 CB216953 BC025256 BP346274 
    CD671143 BX366707 BX378695 BX489378 CN482134 BF314749 AK022603 NM_022369 
    BC015881 BF313403 AI150687 BX281238 AI684707 AU124712 BP345683 AI242434 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for STRA6 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
    SP1:                                      -     -     -           -           -           -                                   -           -                     
    SP2:                                                  -           -           -           -                                   -           -                     
    SP3:                                                              -           -           -     -                             -           -                     
    SP4:                                                                                                                                                            
    SP5:                                      -     -     -           -           -           -                                                                     

    ExUns: 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b
    SP1:              -     -                 -     -                                             
    SP2:              -     -                 -     -                                             
    SP3:              -     -                 -     -                                             
    SP4:              -     -           -     -     -           -                                 
    SP5:                                                                                          


    ECgene alternative splicing isoforms for STRA6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STRA6 expression in normal human tissues (normalized intensities)      STRA6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCAGACCA
    STRA6 Expression
    About this image


    STRA6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Uncategorized (Extraembryonic Tissues)    fully expand to see all 4 entries
             PureStem Progenitor EN7
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Human Iris Pigment Epithelial Cells (HIPEpiC)   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Spinal Ventral Columns
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             Human Iris Pigment Epithelial Cells (HIPEpiC)   

    See STRA6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STRA6

    SOURCE GeneReport for Unigene cluster: Hs.24553

    UniProtKB/Swiss-Prot: STRA6_HUMAN, Q9BX79
    Tissue specificity: Broad expression. In adult eye expressed in sclera, retina, retinal pigment epithelium, and
    trabecular meshwork but not in choroid and iris

        SABiosciences Custom PCR Arrays for STRA6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for STRA6
    OriGene qSTAR qPCR primer pairs in human, mouse for STRA6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STRA6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STRA6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STRA6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for STRA6 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stra61 , 5 stimulated by retinoic acid gene 61, 5 79(n)1
    74.29(a)1
      9 (31.63 cM)5
    208971  NM_009291.21  NP_033317.21 
     580637885 
    chicken
    (Gallus gallus)
    Aves STRA61 stimulated by retinoic acid gene 6 homolog (mouse) 63.27(n)
    52.98(a)
      415301  XM_413689.3  XP_413689.3 
    lizard
    (Anolis carolinensis)
    Reptilia STRA66
    stimulated by retinoic acid 6
    17(a)
    1 ↔ 1
    GL343666.1(207905-233798)
    zebrafish
    (Danio rerio)
    Actinopterygii stra61 stimulated by retinoic acid gene 6 homolog (mouse) 55.77(n)
    44.77(a)
      724007  NM_001045312.1  NP_001038777.1 


    ENSEMBL Gene Tree for STRA6 (if available)
    TreeFam Gene Tree for STRA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/804 SNPs in STRA6 are shown (see all 804)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0371694
    Microphthalmia, syndromic, 9 (MCOPS9)4--see VAR_0371692 P L mis40--------
    VAR_0371744
    Microphthalmia, syndromic, 9 (MCOPS9)4--see VAR_0371742 T M mis40--------
    VAR_0371684
    Microphthalmia, syndromic, 9 (MCOPS9)4--see VAR_0371682 P L mis40--------
    VAR_0668494
    Microphthalmia, syndromic, 9 (MCOPS9)4--see VAR_0668492 G K mis40--------
    VAR_0371754
    Microphthalmia, syndromic, 9 (MCOPS9)4--see VAR_0371752 R C mis40--------
    rs1182039621,2,4
    C,FMicrophthalmia, syndromic, 9 (MCOPS9)4 pathogenic154530555(-) TACCCA/CCTATC 14 T P mis11Minor allele frequency- C:0.00NA 4256
    rs1182039601,2
    Cpathogenic154521464(-) CTACAC/TGCTGC 14 T M mis11Minor allele frequency- T:0.00NA 4550
    rs1182039581,2
    Cpathogenic154532200(-) TCTCCC/TGCTGA 14 P L mis10--------
    VAR_0602034
    ----see VAR_0602032 G E mis40--------
    VAR_0602054
    ----see VAR_0602052 R P mis40--------

    HapMap Linkage Disequilibrium report for STRA6 (74471807 - 74504608 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for STRA6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833054CNV Loss17160897
    dgv2405n71CNV Loss21882294
    nsv471253CNV Loss18288195
    dgv2404n71CNV Loss21882294
    nsv833053CNV Loss17160897
    nsv510938CNV Complex20534489


    Human Gene Mutation Database (HGMD): STRA6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing STRA6
    DNA2.0 Custom Variant and Variant Library Synthesis for STRA6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610745   
    OMIM disorders: 601186  
    UniProtKB/Swiss-Prot: STRA6_HUMAN, Q9BX79
  • Microphthalmia, syndromic, 9 (MCOPS9) [MIM:601186]: A rare clinical entity including as main
    characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia. Microphthalmia is a
    disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular
    tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that
    include non-ocular abnormalities. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Note=Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye
    characterized by an abnormally small ocular globe

  • 16 diseases for STRA6:    About MalaCards
    diaphragmatic eventration    microphthalmia syndromic 9    alveolar capillary dysplasia    microphthalmia
    imperforate anus    anophthalmia/microphthalmia    congenital heart defect    congenital diaphragmatic hernia
    hernia    coloboma    choroiditis    intrahepatic cholangiocarcinoma
    cholangiocarcinoma    mental retardation    retinitis    colorectal cancer

    3 diseases from the University of Copenhagen DISEASES database for STRA6:
    Diaphragmatic eventration     Congenital diaphragmatic hernia     Microphthalmia

    STRA6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): STRA6
    Human Genome Epidemiology (HuGE) Navigator: STRA6 (3 documents)

    Export disorders for STRA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STRA6 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with STRA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of STRA6 and SKI sequence variants in patients with anophthalmia/microphthalmia. (PubMed id 19112531)1, 2, 4 White T.... Young T.L. (2008)
    2. First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: A new dimension to the STRA6 phenotype. (PubMed id 21901792)1, 2 Casey J.... Ennis S. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Case-control analysis of SNPs in GLUT4, RBP4 and STRA 6: association of SNPs in STRA6 with type 2 diabetes in a South Indian populati on. (PubMed id 20625434)1, 4 Nair A.K....Anilkumar G. (2010)
    5. Phenotypic spectrum of STRA6 mutations: from Matthew-Wood syndrome to non-lethal anophthalmia. (PubMed id 19309693)1, 2 Chassaing N.... Calvas P. (2009)
    6. Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation. (PubMed id 17273977)1, 2 Pasutto F.... Rauch A. (2007)
    7. Matthew-Wood syndrome is caused by truncating mutations in the retinol-binding protein receptor gene STRA6. (PubMed id 17503335)1, 2 Golzio C....Etchevers H.C. (2007)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    10. Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid. (PubMed id 11358845)1, 2 Szeto W....Pennica D. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64220 HGNC: 30650 AceView: FLJ12541 Ensembl:ENSG00000137868 euGenes: HUgn64220
    ECgene: STRA6 H-InvDB: STRA6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STRA6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STRA6 gene:
    Search GeneIP for patents involving STRA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for STRA6 (STRA6)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for STRA6 (STRA6)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for STRA6  
     OriGene qPCR primer pairs and template standards for STRA6   OriGene Protein Over-expression Lysate for STRA6  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for STRA6  
     OriGene qSTAR qPCR primer pairs in human, mouse for STRA6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for STRA6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for STRA6   OriGene Custom Protein Services for STRA6  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STRA6
     QIAGEN SeqTarget long-range PCR primers for resequencing STRA6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STRA6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STRA6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STRA6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STRA6
     GenScript Custom Purified and Recombinant Proteins Services for STRA6 GenScript cDNA clones with any tag delivered in your preferred vector for STRA6
     GenScript Custom Assay Services for STRA6 GenScript Custom Superior Antibodies Services for STRA6
     GenScript Custom overexpressing Cell Line Services for STRA6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in STRA6 promoter
     Search Chromatin IP Primers for STRA6
     RT2 qPCR Primer Assay in human, mouse, rat STRA6
     Search GNC Networks for STRA6
     SABiosciences Custom PCR Arrays for STRA6
     Search Tocris compounds for STRA6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     STRA6 antibodies
     STRA6 proteins
     STRA6 lysates
     Antibodies for STRA6
     See all of Abcam's Antibodies, Kits and Proteins for STRA6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for STRA6
     Antibodies for STRA6
     ELISAs for STRA6
     CLIAs for STRA6
     Search LifeMap BioReagents cell lines for STRA6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRA6
     SwitchGear 3'UTR luciferase reporter plasmids for STRA6
     SwitchGear Promoter luciferase reporter plasmids for STRA6
     ThermoFisher Antibody for STRA6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRA6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for STRA6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STRA6
    Customized:
     lentivirus for stable overexpression of STRA6
     lentivirus expression plasmids for stable overexpression of STRA6
     adenovirus for overexpression of STRA6
     LSBio Antibodies in human, mouse, rat for STRA6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      STRA6 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4