Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STRA13 Gene

Aliases for STRA13 Gene

  • Stimulated By Retinoic Acid 13 2 3
  • FAAP10 3 4 6
  • CENPX 3 4 6
  • MHF2 3 4 6
  • Stimulated By Retinoic Acid Gene 13 Protein Homolog 3 4
  • Retinoic Acid-Inducible Gene D9 Protein Homolog 3 4
  • Fanconi Anemia-Associated Polypeptide Of 10 KDa 3 4
  • FANCM-Interacting Histone Fold Protein 2 3 4
  • CENP-X 3 4
  • D9 3 6
  • Stimulated By Retinoic Acid 13 Homolog (Mouse) 2
  • Stimulated By Retinoic Acid 13 Homolog 3
  • Centromere Protein X 3

External Ids for STRA13 Gene

Previous GeneCards Identifiers for STRA13 Gene

  • GC03U990073
  • GC17M080512
  • GC17M080655
  • GC17M077569
  • GC17M079977
  • GC17M075376

Summaries for STRA13 Gene

GeneCards Summary for STRA13 Gene

STRA13 (Stimulated By Retinoic Acid 13) is a Protein Coding gene. Among its related pathways are Fanconi anemia pathway (KEGG). GO annotations related to this gene include double-stranded DNA binding.

UniProtKB/Swiss-Prot for STRA13 Gene

  • DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRA13 Gene

Genomics for STRA13 Gene

Regulatory Elements for STRA13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STRA13 Gene

Start:
82,018,702 bp from pter
End:
82,024,107 bp from pter
Size:
5,406 bases
Orientation:
Minus strand

Genomic View for STRA13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STRA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRA13 Gene

Proteins for STRA13 Gene

  • Protein details for STRA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MT69-CENPX_HUMAN
    Recommended name:
    Centromere protein X
    Protein Accession:
    A8MT69
    Secondary Accessions:
    • O00281
    • O00282
    • Q96DD4
    • Q96F51

    Protein attributes for STRA13 Gene

    Size:
    81 amino acids
    Molecular mass:
    8959 Da
    Quaternary structure:
    • Belongs to the multisubunit FA complex composed of APITD1/CENPS, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and STRA13/CENPX. Interacts with APITD1/CENPS, FANCM and FAAP24. Component of a discrete APITD1/CENPS complex composed of at least APITD1/CENPS and STRA13/CENPX; this complex binds DNA. The heterodimer composed of APITD1/CENPS and STRA13/CENPX can dimerize to form a heterotetramer. Component of a heterotetrameric CENP-T-W-S-X complex composed of APITD1/CENPS, STRA13/CENPX, CENPT and CENPW.

    Three dimensional structures from OCA and Proteopedia for STRA13 Gene

    Alternative splice isoforms for STRA13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRA13 Gene

Proteomics data for STRA13 Gene at MOPED

Post-translational modifications for STRA13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STRA13 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for STRA13

No data available for DME Specific Peptides for STRA13 Gene

Domains for STRA13 Gene

Protein Domains for STRA13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STRA13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MT69

UniProtKB/Swiss-Prot:

CENPX_HUMAN :
  • A8MT69
Family:
  • Belongs to the CENPX family.
genes like me logo Genes that share domains with STRA13: view

No data available for Gene Families for STRA13 Gene

Function for STRA13 Gene

Molecular function for STRA13 Gene

GENATLAS Biochemistry:
stimulated by retinoic acid 13,dysregulated in leukemogenesis and solid tumor,expressed (in mouse) in the neuroectoderm and also in a number of mesodermal and endodermal derivatives,functioning as a repressor of activated transcription and interacting with general factors of the basal transcription machinery, putatively involved in the control of differentiation of several cell lineages during mouse development
UniProtKB/Swiss-Prot Function:
DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation.

Gene Ontology (GO) - Molecular Function for STRA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 20347429
GO:0003690 contributes_to double-stranded DNA binding IDA 20347428
GO:0005515 protein binding IPI 20347429
GO:0046982 protein heterodimerization activity --
genes like me logo Genes that share ontologies with STRA13: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for STRA13 Gene

Localization for STRA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRA13 Gene

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STRA13 Gene COMPARTMENTS Subcellular localization image for STRA13 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for STRA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005654 nucleoplasm TAS --
GO:0043240 Fanconi anaemia nuclear complex IDA 20347428
GO:0071821 FANCM-MHF complex IDA 20347428
genes like me logo Genes that share ontologies with STRA13: view

Pathways for STRA13 Gene

SuperPathways for STRA13 Gene

Superpath Contained pathways
1 Fanconi anemia pathway (KEGG)
genes like me logo Genes that share pathways with STRA13: view

Pathways by source for STRA13 Gene

1 KEGG pathway for STRA13 Gene

Gene Ontology (GO) - Biological Process for STRA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 resolution of meiotic recombination intermediates IMP 20347428
GO:0006281 DNA repair IEA --
GO:0006334 nucleosome assembly TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0031297 replication fork processing IMP 20347428
genes like me logo Genes that share ontologies with STRA13: view

Transcripts for STRA13 Gene

Unigene Clusters for STRA13 Gene

Stimulated by retinoic acid 13:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STRA13

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRA13 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - -
SP2: -
SP3: - - -
SP4:
SP5: -
SP6: - - - - - - - -
SP7: - - -
SP8: - - - -
SP9: - -
SP10: -

Relevant External Links for STRA13 Gene

GeneLoc Exon Structure for
STRA13
ECgene alternative splicing isoforms for
STRA13

Expression for STRA13 Gene

mRNA expression in normal human tissues for STRA13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for STRA13 Gene

This gene is overexpressed in CD4 Tcells (29.6), Fetal ovary (27.5), and Fetal Liver (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STRA13 Gene

SOURCE GeneReport for Unigene cluster for STRA13 Gene Hs.37616

genes like me logo Genes that share expressions with STRA13: view

Expression partners for STRA13 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STRA13 Gene

Orthologs for STRA13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STRA13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STRA13 35
  • 81.58 (n)
  • 80.26 (a)
STRA13 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stra13 35
  • 81.2 (n)
  • 83.33 (a)
Stra13 16
Stra13 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STRA13 35
  • 99.18 (n)
  • 98.77 (a)
STRA13 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC688314 35
  • 76 (n)
  • 81.33 (a)
dog
(Canis familiaris)
Mammalia STRA13 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRA13 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii stra13 36
  • 52 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for STRA13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STRA13 Gene

ENSEMBL:
Gene Tree for STRA13 (if available)
TreeFam:
Gene Tree for STRA13 (if available)

Paralogs for STRA13 Gene

No data available for Paralogs for STRA13 Gene

Variants for STRA13 Gene

Sequence variations from dbSNP and Humsavar for STRA13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4246443 -- 82,020,718(-) CCTCC(A/G)TCCAT intron-variant
rs4432307 -- 82,020,947(-) GGGCC(A/G)CCTCA intron-variant
rs4969469 -- 82,020,129(-) CCCTG(C/T)GCAGG intron-variant
rs4969470 -- 82,020,094(-) GCCCA(C/T)GCATC intron-variant
rs4969471 -- 82,019,937(-) GGGGC(C/G)TGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STRA13 Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3337n71 CNV Loss 21882294
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
nsv909160 CNV Gain 21882294
nsv909161 CNV Loss 21882294
dgv3343n71 CNV Loss 21882294
nsv909166 CNV Loss 21882294
nsv457975 CNV Loss 19166990
nsv909167 CNV Gain+Loss 21882294
dgv3344n71 CNV Loss 21882294
dgv3345n71 CNV Loss 21882294
dgv3346n71 CNV Loss 21882294
dgv3347n71 CNV Loss 21882294

Relevant External Links for STRA13 Gene

HapMap Linkage Disequilibrium report
STRA13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRA13 Gene

Disorders for STRA13 Gene

(1) University of Copenhagen DISEASES for STRA13 Gene

Relevant External Links for STRA13

Genetic Association Database (GAD)
STRA13
Human Genome Epidemiology (HuGE) Navigator
STRA13
genes like me logo Genes that share disorders with STRA13: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for STRA13 Gene

Publications for STRA13 Gene

  1. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban H.J. … Park K.J. (BMC Genet. 2010) 3 48
  2. E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha. (PMID: 8839844) Scott L.M. … Collins S.J. (Blood 1996) 2 3
  3. The CENP-S complex is essential for the stable assembly of outer kinetochore structure. (PMID: 19620631) Amano M. … Fukagawa T. (J. Cell Biol. 2009) 3 4
  4. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. (PMID: 20347428) Yan Z. … Wang W. (Mol. Cell 2010) 3
  5. MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. (PMID: 20347429) Singh T.R. … Meetei A.R. (Mol. Cell 2010) 3

Products for STRA13 Gene

Sources for STRA13 Gene

Back to Top

Content