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Aliases for STPG4 Gene

Aliases for STPG4 Gene

  • Sperm-Tail PG-Rich Repeat Containing 4 2 3 5
  • Sperm-Tail PG-Rich Repeat-Containing Protein 4 3 4
  • Gonad-Specific Expression Gene Protein 3 4
  • C2orf61 3 4
  • GSE 3 4
  • Chromosome 2 Open Reading Frame 61 2
  • Uncharacterized Protein C2orf61 3
  • Protein STPG4 3

External Ids for STPG4 Gene

Previous HGNC Symbols for STPG4 Gene

  • C2orf61

Previous GeneCards Identifiers for STPG4 Gene

  • GC02M047066

Summaries for STPG4 Gene

GeneCards Summary for STPG4 Gene

STPG4 (Sperm-Tail PG-Rich Repeat Containing 4) is a Protein Coding gene. An important paralog of this gene is ENSG00000273269.

UniProtKB/Swiss-Prot for STPG4 Gene

  • Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC).

Additional gene information for STPG4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STPG4 Gene

Genomics for STPG4 Gene

Regulatory Elements for STPG4 Gene

Enhancers for STPG4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H047065 2.5 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.6 +82.4 82442 15.3 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 TTC7A CALM2 LOC100506142 ENSG00000233845 STPG4 MSH6 MCFD2 ENSG00000225187
GH02H046870 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +280.5 280484 9.2 HDGF FOXA2 PKNOX1 SIN3A YBX1 ZNF2 YY1 ZNF766 ZNF207 FOS TTC7A SOCS5 MSH6 MCFD2 STPG4 MSH2 GC02M046879 ENSG00000226548
GH02H047322 1.5 Ensembl ENCODE dbSUPER 10.5 -168.0 -167979 1.2 HDGF PKNOX1 ATF1 ARNT ZFP64 ARID4B SIN3A BRCA1 ZNF2 TCF12 MSH6 TTC7A ENSG00000228925 RPL18AP6 STPG4 SOCS5 FBXO11 LOC100506142 ENSG00000225187 LOC101927043
GH02H047268 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.7 -116.8 -116828 6.7 HDGF FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNF143 FOS MSH6 ENSG00000228925 FBXO11 SOCS5 ENSG00000233845 ENSG00000225187 CALM2 RPL18AP6 MSH2 STPG4
GH02H047038 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.9 +113.3 113314 6.8 MLX ARID4B SIN3A YY1 FOS ZHX2 REST PPARG KAT8 NFIL3 STPG4 ENSG00000233845 ENSG00000225187
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STPG4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for STPG4 Gene

Genomic Locations for STPG4 Gene
chr2:47,045,538-47,155,378
(GRCh38/hg38)
Size:
109,841 bases
Orientation:
Minus strand
chr2:47,272,677-47,382,517
(GRCh37/hg19)

Genomic View for STPG4 Gene

Genes around STPG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STPG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STPG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STPG4 Gene

Proteins for STPG4 Gene

  • Protein details for STPG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N801-STPG4_HUMAN
    Recommended name:
    Protein STPG4
    Protein Accession:
    Q8N801
    Secondary Accessions:
    • H7C2Z2

    Protein attributes for STPG4 Gene

    Size:
    248 amino acids
    Molecular mass:
    27807 Da
    Quaternary structure:
    • Interacts with histone H3. Interacts with histone H4.

    Alternative splice isoforms for STPG4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STPG4 Gene

Post-translational modifications for STPG4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STPG4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STPG4 Gene

Domains & Families for STPG4 Gene

Gene Families for STPG4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STPG4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STPG4: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for STPG4 Gene

Function for STPG4 Gene

Molecular function for STPG4 Gene

UniProtKB/Swiss-Prot Function:
Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC).

Phenotypes From GWAS Catalog for STPG4 Gene

Gene Ontology (GO) - Molecular Function for STPG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding ISS --
genes like me logo Genes that share ontologies with STPG4: view
genes like me logo Genes that share phenotypes with STPG4: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STPG4 Gene

Localization for STPG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STPG4 Gene

Cytoplasm. Nucleus. Note=Localizes in female and male zygote pronucleus. Associates preferentially with the paternal chromatin during zygote development. {ECO:0000250 UniProtKB:Q9DAG5}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STPG4 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STPG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001939 female pronucleus ISS --
GO:0001940 male pronucleus ISS --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0042585 germinal vesicle ISS --
genes like me logo Genes that share ontologies with STPG4: view

Pathways & Interactions for STPG4 Gene

SuperPathways for STPG4 Gene

No Data Available

Interacting Proteins for STPG4 Gene

Gene Ontology (GO) - Biological Process for STPG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016569 covalent chromatin modification IEA --
GO:0044727 DNA demethylation of male pronucleus ISS --
GO:1901537 positive regulation of DNA demethylation ISS --
genes like me logo Genes that share ontologies with STPG4: view

No data available for Pathways by source and SIGNOR curated interactions for STPG4 Gene

Drugs & Compounds for STPG4 Gene

No Compound Related Data Available

Transcripts for STPG4 Gene

mRNA/cDNA for STPG4 Gene

(2) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STPG4 Gene

No ASD Table

Relevant External Links for STPG4 Gene

GeneLoc Exon Structure for
STPG4
ECgene alternative splicing isoforms for
STPG4

Expression for STPG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of STPG4 Gene:

STPG4
genes like me logo Genes that share expression patterns with STPG4: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for STPG4 Gene

Orthologs for STPG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STPG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf61 33
  • 99.42 (n)
C2orf61 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C2orf61 34
  • 89 (a)
OneToOne
C10H2orf61 33
  • 85.7 (n)
mouse
(Mus musculus)
Mammalia 1700011E24Rik 33 34
  • 77.69 (n)
Stpg4 16
rat
(Rattus norvegicus)
Mammalia LOC681766 33
  • 76.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C2orf61 34
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C2orf61 34
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C2orf61 34
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497472 33
  • 53.27 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100332264 33
  • 45.85 (n)
C2orf61 34
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4094 34
  • 30 (a)
OneToOne
Species where no ortholog for STPG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STPG4 Gene

ENSEMBL:
Gene Tree for STPG4 (if available)
TreeFam:
Gene Tree for STPG4 (if available)

Paralogs for STPG4 Gene

Paralogs for STPG4 Gene

genes like me logo Genes that share paralogs with STPG4: view

Variants for STPG4 Gene

Sequence variations from dbSNP and Humsavar for STPG4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000000482 -- 47,087,805(+) TGTAG(G/T)GCGCG intron-variant
rs1000068033 -- 47,129,037(+) CAGTG(G/T)ATTCT intron-variant, utr-variant-3-prime
rs1000074800 -- 47,089,294(+) TTCAC(C/T)GGCAG intron-variant
rs1000082160 -- 47,149,482(+) CTAGT(A/G)TAATT intron-variant
rs1000093617 -- 47,095,877(+) GGAGA(C/G)GGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STPG4 Gene

Variant ID Type Subtype PubMed ID
nsv963228 CNV duplication 23825009
nsv581754 CNV gain 21841781
nsv581749 CNV loss 21841781
nsv498921 CNV loss 21111241
nsv457352 CNV loss 19166990
nsv2716 CNV deletion 18451855
nsv1004828 CNV gain 25217958
esv3892059 CNV loss 25118596
esv3590623 CNV loss 21293372
esv3590622 CNV gain 21293372
esv3590621 CNV loss 21293372
esv2762549 CNV loss 21179565
esv2669653 CNV deletion 23128226
esv2471188 CNV insertion 19546169

Variation tolerance for STPG4 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STPG4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STPG4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STPG4 Gene

Disorders for STPG4 Gene

Relevant External Links for STPG4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STPG4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STPG4

No disorders were found for STPG4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STPG4 Gene

Publications for STPG4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2016) 3 60
  3. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber MJ … Krauss RM (PloS one 2010) 3 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for STPG4 Gene

Sources for STPG4 Gene

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