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Aliases for STPG4 Gene

Aliases for STPG4 Gene

  • Sperm-Tail PG-Rich Repeat Containing 4 2 3
  • C2orf61 3 4 5
  • Chromosome 2 Open Reading Frame 61 2 5
  • Uncharacterized Protein C2orf61 3

External Ids for STPG4 Gene

Previous HGNC Symbols for STPG4 Gene

  • C2orf61

Summaries for STPG4 Gene

GeneCards Summary for STPG4 Gene

STPG4 (Sperm-Tail PG-Rich Repeat Containing 4) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STPG4 Gene

Genomics for STPG4 Gene

Regulatory Elements for STPG4 Gene

Enhancers for STPG4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G047268 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.7 -95.7 -95695 6.7 HDGF FOXA2 ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 CBX5 ZNF207 ENSG00000228925 SOCS5 CALM2 RPL18AP6 MSH2 ENSG00000233845 STPG4 PIR36995 ENSG00000226087
GH02G047038 2 FANTOM5 Ensembl ENCODE dbSUPER 4.8 +134.4 134447 6.8 HDGF FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000228925 SOCS5 ENSG00000233845 RPL18AP6 STPG4 ENSG00000225187
GH02G047169 1.7 Ensembl ENCODE dbSUPER 5 +2.7 2660 8.4 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 SOCS5 ENSG00000228925 RPL18AP6 ENSG00000225187 ATP6V1E2 STPG4
GH02G047031 1.6 Ensembl ENCODE dbSUPER 4.7 +141.9 141875 6.6 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 CALM2 STPG4 EPCAM BCYRN1 ENSG00000233845 GC02M046968
GH02G047036 1.1 ENCODE dbSUPER 4.4 +146.3 146256 1.2 ELF3 FOXA2 ARID4B RAD21 THRB RARA SCRT2 ZNF143 FOS MIXL1 ENSG00000225187 CALM2 STPG4 ENSG00000233845 GC02M046968
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STPG4 on UCSC Golden Path with GeneCards custom track

Promoters for STPG4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000116785 1011 3401 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for STPG4 Gene

Chromosome:
2
Start:
47,065,941 bp from pter
End:
47,176,511 bp from pter
Size:
110,571 bases
Orientation:
Minus strand

Genomic View for STPG4 Gene

Genes around STPG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STPG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STPG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STPG4 Gene

Proteins for STPG4 Gene

  • Protein details for STPG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N801-CB061_HUMAN
    Recommended name:
    Uncharacterized protein C2orf61
    Protein Accession:
    Q8N801
    Secondary Accessions:
    • H7C2Z2

    Protein attributes for STPG4 Gene

    Size:
    248 amino acids
    Molecular mass:
    27807 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STPG4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STPG4 Gene

Post-translational modifications for STPG4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STPG4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STPG4 Gene

Domains & Families for STPG4 Gene

Protein Domains for STPG4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STPG4: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for STPG4 Gene

Function for STPG4 Gene

genes like me logo Genes that share phenotypes with STPG4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STPG4 Gene

Localization for STPG4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STPG4 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for STPG4 Gene

Pathways & Interactions for STPG4 Gene

SuperPathways for STPG4 Gene

No Data Available

Interacting Proteins for STPG4 Gene

Gene Ontology (GO) - Biological Process for STPG4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for STPG4 Gene

Transcripts for STPG4 Gene

mRNA/cDNA for STPG4 Gene

(2) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STPG4 Gene

No ASD Table

Relevant External Links for STPG4 Gene

GeneLoc Exon Structure for
STPG4
ECgene alternative splicing isoforms for
STPG4

Expression for STPG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of STPG4 Gene:

STPG4
genes like me logo Genes that share expression patterns with STPG4: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for STPG4 Gene

Orthologs for STPG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STPG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf61 34
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia C10H2orf61 34
  • 85.7 (n)
mouse
(Mus musculus)
Mammalia 1700011E24Rik 34
  • 77.69 (n)
Stpg4 16
rat
(Rattus norvegicus)
Mammalia LOC681766 34
  • 76.45 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497472 34
  • 53.27 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100332264 34
  • 45.85 (n)
Species where no ortholog for STPG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STPG4 Gene

ENSEMBL:
Gene Tree for STPG4 (if available)
TreeFam:
Gene Tree for STPG4 (if available)

Paralogs for STPG4 Gene

No data available for Paralogs for STPG4 Gene

Variants for STPG4 Gene

Sequence variations from dbSNP and Humsavar for STPG4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000000482 -- 47,087,805(+) TGTAG(G/T)GCGCG intron-variant
rs1000068033 -- 47,129,037(+) CAGTG(G/T)ATTCT intron-variant, utr-variant-3-prime
rs1000074800 -- 47,089,294(+) TTCAC(C/T)GGCAG intron-variant
rs1000082160 -- 47,149,482(+) CTAGT(A/G)TAATT intron-variant
rs1000093617 -- 47,095,877(+) GGAGA(C/G)GGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STPG4 Gene

Variant ID Type Subtype PubMed ID
esv2471188 CNV insertion 19546169
esv2669653 CNV deletion 23128226
esv2762549 CNV loss 21179565
esv3590621 CNV loss 21293372
esv3590622 CNV gain 21293372
esv3590623 CNV loss 21293372
esv3892059 CNV loss 25118596
nsv1004828 CNV gain 25217958
nsv2716 CNV deletion 18451855
nsv457352 CNV loss 19166990
nsv498921 CNV loss 21111241
nsv581749 CNV loss 21841781
nsv581754 CNV gain 21841781
nsv963228 CNV duplication 23825009

Variation tolerance for STPG4 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STPG4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STPG4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STPG4 Gene

Disorders for STPG4 Gene

Relevant External Links for STPG4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STPG4

No disorders were found for STPG4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STPG4 Gene

Publications for STPG4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64

Products for STPG4 Gene

Sources for STPG4 Gene

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