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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STPG2 Gene

protein-coding   GIFtS: 30
GCID: GC04M098105

Sperm-Tail PG-Rich Repeat Containing 2

(Previous name: chromosome 4 open reading frame 37)
(Previous symbol: C4orf37)
  Search for STPG2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sperm-Tail PG-Rich Repeat Containing 21 2
C4orf371 2 3
Chromosome 4 Open Reading Frame 371
Sperm-Tail PG-Rich Repeat-Containing Protein 22

External Ids:    HGNC: 287121   Entrez Gene: 2855552   Ensembl: ENSG000001631167   UniProtKB: Q8N4123   

Export aliases for STPG2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for STPG2 Gene: 
STPG2 (sperm-tail PG-rich repeat containing 2) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for STPG2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for STPG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STPG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.3-q23   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q22.3-q23

STPG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STPG2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M098105:  view genomic region     (about GC identifiers)

Start:
98,105,244 bp from pter      End:
99,064,391 bp from pter
Size:
959,148 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STPG2_HUMAN, Q8N412 (See protein sequence)
Recommended Name: Sperm-tail PG-rich repeat-containing protein 2  
Size: 459 amino acids; 50660 Da

Explore the universe of human proteins at neXtProt for STPG2: NX_Q8N412

Explore proteomics data for STPG2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N412

  • STPG2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STPG2 Protein Expression
    REFSEQ proteins: NP_777612.1  
    ENSEMBL proteins: 
     ENSP00000428346   ENSP00000295268  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR010736 SHIPPO-rpt

    Graphical View of Domain Structure for InterPro Entry Q8N412

    ProtoNet protein and cluster: Q8N412

    UniProtKB/Swiss-Prot: STPG2_HUMAN, Q8N412
    Similarity: Contains 9 STPGR (Sperm-tail PG-rich) repeats


    STPG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STPG2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STPG2

    Search CenterWatch for drugs/clinical trials and news about STPG2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for STPG2 gene: 
    NM_174952.2  

    Unigene Cluster for STPG2:

    Sperm-tail PG-rich repeat containing 2
    Hs.680226  [show with all ESTs]
    Unigene Representative Sequence: BX648305
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522676 ENST00000506482 ENST00000295268(uc003htt.2)
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    Additional mRNA sequence: 

    BC036870.1 BX648305.1 

    2 DOTS entries:

    DT.99932648  DT.91976114 

    4 AceView cDNA sequences:

    BX648305 BG211405 BC036870 NM_174952 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See STPG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STPG2

    SOURCE GeneReport for Unigene cluster: Hs.680226
        SABiosciences Custom PCR Arrays for STPG2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STPG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for STPG2 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stpg21 , 5 RIKEN cDNA B930007M17 gene5
    sperm tail PG rich repeat containing 21
    76.19(n)1
    62.44(a)1
      3 (64.68 cM)5
    3814761  NM_198659.21  NP_941061.11 
     1392056945 
    lizard
    (Anolis carolinensis)
    Reptilia STPG26
    sperm-tail PG-rich repeat containing 2
    36(a)
    1 ↔ 1
    GL343307.1(880156-1130310)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1539871 zgc:153987 51.04(n)
    42.49(a)
      768205  NM_001077347.1  NP_001070815.1 


    ENSEMBL Gene Tree for STPG2 (if available)
    TreeFam Gene Tree for STPG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STPG2 gene

    STPG2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STPG2
    PGOHUM00000234950


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/11118 SNPs in STPG2 are shown (see all 11118)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106226641,2
    C--94750184(+) AATAA-/AT    
       A
    /TAA
    CTATC
    2 -- cds10--------
    rs1432442631,2
    --98479550(+) GGTGAC/TTCGCC 1 -- ds50010--------
    rs1130986891,2
    C--98479669(+) AAGCCAGCT/-  
            
    AGCTG
    1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs1932199601,2
    --98479690(+) TGCTAC/TGCTAT 1 -- ds50010--------
    rs1466858451,2
    --98479777(+) AGCCCA/GTGTGG 1 -- ds50010--------
    rs1401422511,2
    --98480083(+) TGAGCA/GAATGC 1 -- ut310--------
    rs1856416851,2
    --98480089(+) AATGCC/TTGAAC 1 -- ut310--------
    rs1132286291,2
    F--98480135(+) GAATAC/AATTTT 1 -- ut313Minor allele frequency- A:0.50CSA 8
    rs1398052251,2
    C,F--98480255(+) TCTTTT/CTCTCC 2 /K /R mis11Minor allele frequency- C:0.00NA 4454
    rs1839499971,2
    C--98480280(+) AATAAC/GAATGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for STPG2 (98105244 - 98355244 bp, first 250kb of STPG2)

    Structural Variations
          Database of Genomic Variants (DGV) variations for STPG2: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STPG2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with STPG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Exceptional complex chromosomal rearrangement and micr odeletions at the 4q22.3q23 and 14q31.1q31.3 regions in a patient with azoosperm ia. (PubMed id 23031811)1, 3 Yakut S....Luleci G. (2013)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285555 HGNC: 28712 AceView: MGC46496 Ensembl:ENSG00000163116 euGenes: HUgn285555
    ECgene: STPG2 H-InvDB: STPG2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STPG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STPG2 gene:
    Search GeneIP for patents involving STPG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STPG2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for STPG2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STPG2
    Customized:
     lentivirus for stable overexpression of STPG2
     lentivirus expression plasmids for stable overexpression of STPG2
     adenovirus for overexpression of STPG2
     Search LSBio for Antibodies for STPG2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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