STPG1 Gene
protein-coding GIFtS: 36
GCID: GC01M024684
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sperm-tail PG-rich repeat containing 1(Previous name: chromosome 1 open reading frame 201 )
(Previous symbol: C1orf201)
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Aliases
for STPG1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sperm-Tail PG-Rich Repeat Containing 11 2 | | Chromosome 1 Open Reading Frame 2011 | | C1orf2011 2 3 | | O(6)-Methylguanine-Induced Apoptosis 22 | | MAPO21 2 3 | | O6-Methylguanine-Induced Apoptosis 22 | | Sperm-Tail PG-Rich Repeat-Containing Protein 12 3 | | UPF0490 Protein C1orf2012 | | FLJ333401 | | |
Export aliases for STPG1 gene to outside databases |
Summaries
for STPG1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: STPG1_HUMAN, Q5TH74Function: May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine
|
Genomic Views
for STPG1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for STPG1
Other transcription factors
Search SABiosciences Chromatin IP Primers for STPG1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STPG1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.11STPG1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M024684: view genomic region
(about GC identifiers)
Start:
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24,683,489 bp from pter |
End:
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24,743,424 bp from pter |
Size:
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59,936 bases |
Orientation:
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minus strand |
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Proteins
for STPG1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STPG1_HUMAN, Q5TH74 (See
protein sequence)Recommended Name: O(6)-methylguanine-induced apoptosis 2 Size: 334 amino acids; 36786 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: Q49AP0 Q6P3R4 Q86VU9 Q8WVQ3Alternative splicing: 3 isoforms: Q5TH74-1 Q5TH74-2 Q5TH74-3 Explore the universe of human proteins at neXtProt for STPG1: NX_Q5TH74
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TH74
STPG1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001185941.1 NP_001185942.1 NP_001185943.1 NP_835223.1
ENSEMBL proteins: ENSP00000363530 ENSP00000003583 ENSP00000416176 ENSP00000392225 ENSP00000337461 ENSP00000408712
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
STPG1 for ontologies About GeneDecksing
STPG1 Antibody Products:
Assay Products for STPG1: |
Protein
Domains /
Families
for STPG1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STPG1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5TH74ProtoNet protein and cluster: Q5TH74 UniProtKB/Swiss-Prot: STPG1_HUMAN, Q5TH74Similarity: Belongs to the STPG1 familySimilarity: Contains 7 STPGR (Sperm-tail PG-rich) repeats |
Function
for STPG1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STPG1_HUMAN, Q5TH74Function: May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STPG1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STPG1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for STPG1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STPG1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STPG1 |
|
Pathways & Interactions
for STPG1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STPG1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for STPG1 (ENSP000000035834) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006915 | apoptotic process |
IEA | -- |
STPG1 for ontologies About GeneDecksing
|
Drugs & Compounds
for STPG1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STPG1
Search CenterWatch for drugs/clinical trials and news about STPG1
|
Transcripts
for STPG1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STPG1 gene (4 alternative transcripts): NM_001199012.1 NM_001199013.1 NM_001199014.1 NM_178122.4 Unigene Cluster for STPG1: Sperm-tail PG-rich repeat containing 1 Hs.403187 [show with all ESTs]Unigene Representative Sequence: BC03431513 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374409(uc010oej.2 uc001bjd.3) ENST00000003583 ENST00000468303(uc001bjb.3 uc001bjc.3 uc001bja.3)
ENST00000497384(uc001bjf.3) ENST00000438866 ENST00000435187 ENST00000483261
ENST00000498488 ENST00000483528 ENST00000475760 ENST00000492753 ENST00000337248
ENST00000440416
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STPG1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STPG1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for STPG1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STPG1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STPG1 |
Additional cDNA sequence: AK025957.1 BC017650.1 BC034315.1 BC035061.1 BC040212.1 BC047705.1 BC063891.1 12 DOTS entries: DT.101982039 DT.205911 DT.101961506 DT.95266759 DT.121450451 DT.92421926 DT.95266760 DT.97835688 DT.65288409 DT.100751347 DT.121450484 DT.75180554 24/95 AceView cDNA sequences (see all 95): BM725202 BM724790 AA490105 BC047705 BI917854 AI916378 BX370610 BC063891 BF434813 CR591554 NM_178122 BM666616 BC034315 AK025957 BQ772871 N26531 AI247349 AA458597 AI991525 BM905986 AI672547 BV200576 BM701768 AA421237
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for STPG1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b |
|---|
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| SP1: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for STPG1
|
Expression
for STPG1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See STPG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STPG1
SOURCE GeneReport for Unigene cluster: Hs.403187
SABiosciences Custom PCR Arrays for STPG1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STPG1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat STPG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STPG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STPG1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STPG1 |
Orthologs
for STPG1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for STPG1 gene from 3/16 species (see all 16) About this table
ENSEMBL Gene Tree for STPG1 (if available)
TreeFam Gene Tree for STPG1 (if available) |
Paralogs
for STPG1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for STPG1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STPG1 (24683489 - 24743424 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for STPG1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STPG1 |
|
Disorders
/ Diseases
for STPG1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for STPG1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STPG1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with STPG1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O(6)-methylguanine. (PubMed id 23028632)1, 2, 3 Fujikane R.... Hidaka M. (2012)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for STPG1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STPG1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STPG1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STPG1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STPG1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STPG1 gene:
Search GeneIP for patents involving STPG1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STPG1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STPG1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STPG1 | | | OriGene Protein Over-expression Lysate for STPG1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for STPG1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STPG1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STPG1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for STPG1 | | OriGene Custom Protein Services for STPG1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STPG1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STPG1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STPG1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STPG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STPG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STPG1 |
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 |  |  |  | |
| | | | Search Tocris compounds for STPG1 |
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 | | | STPG1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STPG1 |
|  |  |  | | | | Search ThermoFisher Antibodies for STPG1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STPG1 |
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