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Aliases for STPG1 Gene

Aliases for STPG1 Gene

  • Sperm Tail PG-Rich Repeat Containing 1 2 3 5
  • Sperm-Tail PG-Rich Repeat-Containing Protein 1 3 4
  • O6-Methylguanine-Induced Apoptosis 2 2 3
  • C1orf201 3 4
  • MAPO2 3 4
  • O(6)-Methylguanine-Induced Apoptosis 2 3
  • Chromosome 1 Open Reading Frame 201 2
  • UPF0490 Protein C1orf201 3

External Ids for STPG1 Gene

Previous HGNC Symbols for STPG1 Gene

  • C1orf201

Previous GeneCards Identifiers for STPG1 Gene

  • GC01M024684
  • GC01M024685

Summaries for STPG1 Gene

GeneCards Summary for STPG1 Gene

STPG1 (Sperm Tail PG-Rich Repeat Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for STPG1 Gene

  • May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STPG1 Gene

Genomics for STPG1 Gene

Regulatory Elements for STPG1 Gene

Enhancers for STPG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G024438 1.2 ENCODE dbSUPER 29.3 -21.7 -21697 0.6 PKNOX1 ATF1 TCF12 GATA2 FOS JUNB REST ZNF592 ZNF579 SMARCA4 STPG1 NIPAL3 NCMAP LOC105376871 GRHL3 GC01P024477
GH01G024414 1.7 Ensembl ENCODE dbSUPER 19.1 -0.3 -337 5.3 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D ZNF610 ELOA STPG1 ENSG00000261349 NIPAL3 RCAN3 SYF2 NCMAP GC01P024477
GH01G024390 1.5 Ensembl ENCODE dbSUPER 17.9 +24.4 24358 3.4 HDGF WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 FOS SP5 STPG1 NIPAL3 IFNLR1 LOC105376871 GRHL3 NCMAP PIR44101
GH01G024439 1 dbSUPER 26.4 -25.0 -24984 4.7 HDGF FOXA2 MLX ARID4B DMAP1 FEZF1 YY1 SLC30A9 ZNF766 FOS STPG1 NIPAL3 RCAN3 NCMAP LOC105376871 GRHL3 GC01P024477
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STPG1 on UCSC Golden Path with GeneCards custom track

Promoters for STPG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003194 934 1201 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143

Genomic Location for STPG1 Gene

24,356,999 bp from pter
24,416,934 bp from pter
59,936 bases
Minus strand

Genomic View for STPG1 Gene

Genes around STPG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STPG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STPG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STPG1 Gene

Proteins for STPG1 Gene

  • Protein details for STPG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    O(6)-methylguanine-induced apoptosis 2
    Protein Accession:
    Secondary Accessions:
    • Q49AP0
    • Q6P3R4
    • Q86VU9
    • Q8WVQ3

    Protein attributes for STPG1 Gene

    334 amino acids
    Molecular mass:
    36786 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STPG1 Gene


neXtProt entry for STPG1 Gene

Post-translational modifications for STPG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STPG1 Gene

Domains & Families for STPG1 Gene

Protein Domains for STPG1 Gene


Suggested Antigen Peptide Sequences for STPG1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the STPG1 family.
  • Belongs to the STPG1 family.
genes like me logo Genes that share domains with STPG1: view

No data available for Gene Families for STPG1 Gene

Function for STPG1 Gene

Molecular function for STPG1 Gene

UniProtKB/Swiss-Prot Function:
May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine.
genes like me logo Genes that share phenotypes with STPG1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STPG1 Gene

Localization for STPG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STPG1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STPG1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for STPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with STPG1: view

Pathways & Interactions for STPG1 Gene

SuperPathways for STPG1 Gene

No Data Available

Interacting Proteins for STPG1 Gene

Gene Ontology (GO) - Biological Process for STPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with STPG1: view

No data available for Pathways by source and SIGNOR curated interactions for STPG1 Gene

Drugs & Compounds for STPG1 Gene

No Compound Related Data Available

Transcripts for STPG1 Gene

Unigene Clusters for STPG1 Gene

Sperm-tail PG-rich repeat containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for STPG1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - -
SP2: - - - -
SP3: -
SP4: -

Relevant External Links for STPG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STPG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STPG1 Gene

mRNA differential expression in normal tissues according to GTEx for STPG1 Gene

This gene is overexpressed in Testis (x5.1).

Protein differential expression in normal tissues from HIPED for STPG1 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STPG1 Gene

Protein tissue co-expression partners for STPG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STPG1 Gene:


SOURCE GeneReport for Unigene cluster for STPG1 Gene:


Evidence on tissue expression from TISSUES for STPG1 Gene

  • Nervous system(4.2)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with STPG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STPG1 Gene

Orthologs for STPG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STPG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STPG1 34 35
  • 99.3 (n)
(Canis familiaris)
Mammalia STPG1 34 35
  • 84.33 (n)
(Bos Taurus)
Mammalia STPG1 34 35
  • 83.83 (n)
(Rattus norvegicus)
Mammalia Stpg1 34
  • 76.22 (n)
(Mus musculus)
Mammalia Stpg1 34 16 35
  • 75.48 (n)
(Monodelphis domestica)
Mammalia STPG1 35
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia STPG1 35
  • 54 (a)
(Anolis carolinensis)
Reptilia STPG1 35
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stpg1 34
  • 56.88 (n)
(Danio rerio)
Actinopterygii stpg1 34 35
  • 50.69 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
Species where no ortholog for STPG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STPG1 Gene

Gene Tree for STPG1 (if available)
Gene Tree for STPG1 (if available)

Paralogs for STPG1 Gene

No data available for Paralogs for STPG1 Gene

Variants for STPG1 Gene

Sequence variations from dbSNP and Humsavar for STPG1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035614 A breast cancer sample
rs6694170 Benign 24,364,186(+) CCAGG(A/G/T)AAACT intron-variant, reference, missense, stop-gained
rs1000024751 -- 24,357,255(+) GTGAT(A/G)TGTGA intron-variant, utr-variant-3-prime
rs1000111264 -- 24,398,670(+) GTCAA(C/T)ATACA intron-variant
rs1000140329 -- 24,383,053(+) ACTAT(C/T)GACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STPG1 Gene

Variant ID Type Subtype PubMed ID
nsv469575 CNV loss 16826518
nsv834447 CNV loss 17160897

Variation tolerance for STPG1 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.25; 88.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STPG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STPG1 Gene

Disorders for STPG1 Gene

Relevant External Links for STPG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STPG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STPG1 Gene

Publications for STPG1 Gene

  1. The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O(6)-methylguanine. (PMID: 23028632) Fujikane R. … Hidaka M. (PLoS ONE 2012) 2 3 4 64
  2. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 4 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  4. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for STPG1 Gene

Sources for STPG1 Gene

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