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Aliases for STOX2 Gene

Aliases for STOX2 Gene

  • Storkhead Box 2 2 3 5
  • KIAA1392 4

External Ids for STOX2 Gene

Previous GeneCards Identifiers for STOX2 Gene

  • GC04P185202
  • GC04P185063
  • GC04P184827
  • GC04P180581
  • GC04P183853

Summaries for STOX2 Gene

Entrez Gene Summary for STOX2 Gene

  • This gene encodes a Storkhead-box_winged-helix domain containing protein. This protein is differentially expressed in decidual tissue and may be involved in the susceptibility to pre-eclampsia with fetal growth restriction. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for STOX2 Gene

STOX2 (Storkhead Box 2) is a Protein Coding gene. An important paralog of this gene is STOX1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STOX2 Gene

Genomics for STOX2 Gene

Regulatory Elements for STOX2 Gene

Enhancers for STOX2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STOX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for STOX2 Gene

183,796,331 bp from pter
184,023,526 bp from pter
227,196 bases
Plus strand

Genomic View for STOX2 Gene

Genes around STOX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STOX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STOX2 Gene

Proteins for STOX2 Gene

  • Protein details for STOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Storkhead-box protein 2
    Protein Accession:
    Secondary Accessions:
    • A6H8U4
    • Q9NPS8

    Protein attributes for STOX2 Gene

    926 amino acids
    Molecular mass:
    102671 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA92630.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STOX2 Gene


neXtProt entry for STOX2 Gene

Proteomics data for STOX2 Gene at MOPED

Post-translational modifications for STOX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STOX2 Gene

No data available for DME Specific Peptides for STOX2 Gene

Domains & Families for STOX2 Gene

Protein Domains for STOX2 Gene


Suggested Antigen Peptide Sequences for STOX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STOX2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for STOX2 Gene

Function for STOX2 Gene

Phenotypes for STOX2 Gene

genes like me logo Genes that share phenotypes with STOX2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STOX2 Gene

Localization for STOX2 Gene

Subcellular locations from

Jensen Localization Image for STOX2 Gene COMPARTMENTS Subcellular localization image for STOX2 gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for STOX2 Gene

Pathways & Interactions for STOX2 Gene

SuperPathways for STOX2 Gene

No Data Available

Interacting Proteins for STOX2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000311257 for STOX2 Gene via STRING

Gene Ontology (GO) - Biological Process for STOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009790 embryo development IEP 20643876
genes like me logo Genes that share ontologies with STOX2: view

No data available for Pathways by source and SIGNOR curated interactions for STOX2 Gene

Drugs & Compounds for STOX2 Gene

No Compound Related Data Available

Transcripts for STOX2 Gene

Unigene Clusters for STOX2 Gene

Storkhead box 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STOX2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP3: - -

Relevant External Links for STOX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STOX2 Gene

mRNA expression in normal human tissues for STOX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STOX2 Gene

This gene is overexpressed in Amniocyte (57.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STOX2 Gene

SOURCE GeneReport for Unigene cluster for STOX2 Gene Hs.21958

genes like me logo Genes that share expression patterns with STOX2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for STOX2 Gene

Orthologs for STOX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for STOX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STOX2 35
  • 89.27 (n)
  • 94.49 (a)
STOX2 36
  • 94 (a)
(Canis familiaris)
Mammalia STOX2 35
  • 91.32 (n)
  • 95.9 (a)
STOX2 36
  • 96 (a)
(Mus musculus)
Mammalia Stox2 35
  • 88.41 (n)
  • 95.57 (a)
Stox2 16
Stox2 36
  • 96 (a)
(Pan troglodytes)
Mammalia STOX2 35
  • 99.71 (n)
  • 100 (a)
STOX2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Stox2 35
  • 89.09 (n)
  • 95.14 (a)
(Monodelphis domestica)
Mammalia STOX2 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia STOX2 36
  • 89 (a)
(Gallus gallus)
Aves STOX2 35
  • 78.74 (n)
  • 87.59 (a)
STOX2 36
  • 78 (a)
(Anolis carolinensis)
Reptilia STOX2 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stox2 35
  • 74.44 (n)
  • 79.56 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34676 35
(Danio rerio)
Actinopterygii Dr.16351 35
stox2a 35
  • 64.8 (n)
  • 68.8 (a)
STOX2 (2 of 2) 36
  • 61 (a)
stox2a 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta ko 36
  • 11 (a)
(Caenorhabditis elegans)
Secernentea ham-1 36
  • 18 (a)
Species with no ortholog for STOX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STOX2 Gene

Gene Tree for STOX2 (if available)
Gene Tree for STOX2 (if available)

Paralogs for STOX2 Gene

Paralogs for STOX2 Gene

genes like me logo Genes that share paralogs with STOX2: view

Variants for STOX2 Gene

Sequence variations from dbSNP and Humsavar for STOX2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs976712 -- 183,795,152(+) gccca(C/T)gctgt upstream-variant-2KB
rs892835 -- 183,928,303(-) GACCA(C/T)GGGGG intron-variant
rs892836 -- 183,859,884(-) AATCC(C/T)AATAT intron-variant
rs892837 -- 183,859,179(-) AGCGA(G/T)GAGCA intron-variant
rs892838 -- 183,859,119(-) CTATG(A/C)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STOX2 Gene

Variant ID Type Subtype PubMed ID
nsv881675 CNV Gain 21882294
nsv822878 CNV Gain 20364138
nsv830166 CNV Gain 17160897
esv2608282 CNV Deletion 19546169
esv2728882 CNV Deletion 23290073
esv1964372 CNV Deletion 18987734
esv4197 CNV Deletion 18987735
esv2728883 CNV Deletion 23290073
esv2728885 CNV Deletion 23290073
esv2728886 CNV Deletion 23290073
nsv4637 CNV Insertion 18451855

Variation tolerance for STOX2 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.27; 52.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STOX2 Gene

Disorders for STOX2 Gene

Relevant External Links for STOX2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STOX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STOX2 Gene

Publications for STOX2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PMID: 23400010) Del-Aguila J.L. … Boerwinkle E. (Pharmacogenomics J. 2013) 3
  4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for STOX2 Gene

Sources for STOX2 Gene