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STOX1 Gene

protein-coding   GIFtS: 51
GCID: GC10P070587

Storkhead Box 1

(Previous name: chromosome 10 open reading frame 24)
(Previous symbol: C10orf24)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Storkhead Box 11 2
C10orf241 2 3
Winged-Helix Domain-Containing Protein2 3
PEE42 5
Chromosome 10 Open Reading Frame 241
Storkhead-Box Protein 12

External Ids:    HGNC: 235081   Entrez Gene: 2197362   Ensembl: ENSG000001657307   OMIM: 6093975   UniProtKB: Q6ZVD73   

Export aliases for STOX1 gene to outside databases

Previous GC identifers: GC10P070258 GC10P064588


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STOX1 Gene:
The protein encoded by this gene may function as a DNA binding protein. Mutations in this gene are associated with
pre-eclampsia/eclampsia 4 (PEE4). Alternatively spliced transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for STOX1 Gene:
STOX1 (storkhead box 1) is a protein-coding gene. Diseases associated with STOX1 include preeclampsia/eclampsia 4, and eclampsia. An important paralog of this gene is STOX2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STOX1 gene promoter:
         Elk-1   Spz1   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for STOX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STOX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q21.3   HGNC cytogenetic band: 10q22.1

STOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STOX1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P070587:  view genomic region     (about GC identifiers)

Start:
70,587,294 bp from pter      End:
70,655,209 bp from pter
Size:
67,916 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: STOX1_HUMAN, Q6ZVD7 (See protein sequence)
Recommended Name: Storkhead-box protein 1  
Size: 989 amino acids; 110962 Da
Subunit: Binds DNA (By similarity)
Sequence caution: Sequence=AAH63627.1; Type=Erroneous initiation; Sequence=BAB71600.1; Type=Erroneous initiation;
Sequence=BAB71607.1; Type=Erroneous initiation; Sequence=BAC85925.1; Type=Erroneous initiation;
Sequence=BAC87173.1; Type=Erroneous initiation;
Secondary accessions: A2A3Q9 A5D6Y7 B0QZA4 B0QZA5 B0QZA6 Q4F8Q6 Q5I946 Q5I947 Q5I948 Q5VX38
Q5VX39 Q6ZRY3 Q96LR3 Q96LS0
Alternative splicing: 3 isoforms:  Q6ZVD7-1   Q6ZVD7-2   Q6ZVD7-3   

Explore the universe of human proteins at neXtProt for STOX1: NX_Q6ZVD7

Explore proteomics data for STOX1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STOX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001123631.1  NP_001123632.1  NP_001123633.1  NP_001123634.1  NP_689922.3  

    ENSEMBL proteins: 
     ENSP00000298596   ENSP00000382121   ENSP00000382118   ENSP00000382115   ENSP00000394509  

    STOX1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for STOX1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for STOX1
    GenScript Custom Purified and Recombinant Proteins Services for STOX1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STOX1

    STOX1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for STOX1
    OriGene Custom Antibody Services for STOX1
    Novus Biologicals STOX1 Antibody
    Abcam antibodies for STOX1
    Cloud-Clone Corp. Antibodies for STOX1
    ThermoFisher Antibodies for STOX1
    LSBio Antibodies in human, mouse, rat for STOX1

    STOX1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STOX1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STOX1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STOX1
    Cloud-Clone Corp. CLIAs for STOX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019391 Storkhead-box_winged-helix

    Graphical View of Domain Structure for InterPro Entry Q6ZVD7

    ProtoNet protein and cluster: Q6ZVD7


    STOX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    STOX1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STOX1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STOX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STOX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STOX1

    miRNA
    Products:
        
    miRTarBase miRNAs that target STOX1:
    hsa-mir-335-5p (MIRT017203)

    Block miRNA regulation of human, mouse, rat STOX1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate STOX1:
    hsa-miR-150
    SwitchGear 3'UTR luciferase reporter plasmidSTOX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STOX1
    Predesigned siRNA for gene silencing in human, mouse, rat STOX1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STOX1

    Clone
    Products:
         
    OriGene clones in human, mouse for STOX1 (see all 28)
    OriGene ORF clones in mouse, rat for STOX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): STOX1 (NM_152709)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STOX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STOX1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STOX1
    Browse ESI BIO Cell Lines and PureStem Progenitors for STOX1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STOX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STOX1_HUMAN, Q6ZVD7: Isoform A: Cytoplasm. Nucleus. Note=Either found in the cytoplasm or in the nucleus. Nuclear
    expression of isoform A seems to be restricted to polyploid trophoblast cells
    STOX1_HUMAN, Q6ZVD7: Isoform B: Nucleus
    STOX1_HUMAN, Q6ZVD7: Isoform C: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    STOX1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STOX1
    Interactions:

        Search GeneGlobe Interaction Network for STOX1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for STOX1 (ENSP000002985964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GCLMENSP000003592584STRING: ENSP00000359258
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STOX1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STOX1 gene (5 alternative transcripts): 
    NM_001130159.2  NM_001130160.2  NM_001130161.2  NM_001130162.2  NM_152709.4  

    Unigene Cluster for STOX1:

    Storkhead box 1
    Hs.37636  [show with all ESTs]
    Unigene Representative Sequence: NM_152709
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298596(uc001joq.3 uc001jor.3 uc009xpy.3 uc021prw.1)
    ENST00000399169(uc001jos.2) ENST00000399165 ENST00000399162 ENST00000421961


    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STOX1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate STOX1:
    hsa-miR-150
    SwitchGear 3'UTR luciferase reporter plasmidSTOX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STOX1
    Predesigned siRNA for gene silencing in human, mouse, rat STOX1
    Clone
    Products:
         
    OriGene clones in human, mouse for STOX1 (see all 28)
    OriGene ORF clones in mouse, rat for STOX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): STOX1 (NM_152709)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STOX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STOX1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for STOX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STOX1
      QuantiTect SYBR Green Assays in human, mouse, rat STOX1
      QuantiFast Probe-based Assays in human, mouse, rat STOX1

    Additional mRNA sequence: 

    AK057891.1 AK124681.1 AK127878.1 AY842014.1 AY842015.1 AY842016.1 AY842017.1 BC063627.1 
    BC140011.1 

    5 DOTS entries:

    DT.97824045  DT.40111832  DT.212012  DT.100735659  DT.212013 

    Selected AceView cDNA sequences (see all 31):

    BX110231 AW130781 AA453046 AA704430 AK057864 CB241839 AK057891 N34830 
    AK127878 BC063627 AW086180 AK124681 AA442072 BM450800 CK429168 BE904845 
    AA682477 BG677965 AW340422 BQ045446 AA699315 AA470379 H58963 H58917 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for STOX1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
    SP1:                                      -         
    SP2:                          -                     
    SP3:                                                
    SP4:        -                                       
    SP5:                    -     -                     


    ECgene alternative splicing isoforms for STOX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STOX1 expression in normal human tissues (normalized intensities)      STOX1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGAATTGA
    STOX1 Expression
    About this image


    STOX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
     
     Brain (Nervous System)
             N2/LSB/S/F8/CHIR-induced cells
    STOX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STOX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37636
        Custom PCR Arrays for STOX1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for STOX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STOX1
    QuantiTect SYBR Green Assays in human, mouse, rat STOX1
    QuantiFast Probe-based Assays in human, mouse, rat STOX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STOX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STOX1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stox11 , 5 storkhead box 11, 5 71.22(n)1
    61.33(a)1
      10 (32.45 cM)5
    2160211  NM_001033260.11  NP_001028432.11 
     626590435 
    chicken
    (Gallus gallus)
    Aves STOX11 storkhead box 1 53.6(n)
    38.3(a)
      100858074  XM_003641470.2  XP_003641518.2 
    lizard
    (Anolis carolinensis)
    Reptilia STOX16
    storkhead box 1
    38(a)
    1 ↔ 1
    GL343215.1(1829839-1868401)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia stox11 storkhead box 1 54.94(n)
    44.95(a)
      100495850  XM_002936869.2  XP_002936915.2 
    zebrafish
    (Danio rerio)
    Actinopterygii CB891025.12   -- 78.71(n)   378731  CB891025.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ko6
    knockout
    14(a)
    1 → many
    3L(21068681-21124259)
    worm
    (Caenorhabditis elegans)
    Secernentea ham-16
    Protein HAM-1 (ham-1) mRNA, complete cds
    21(a)
    1 → many
    IV(12542034-12545724) WBGene00001820


    ENSEMBL Gene Tree for STOX1 (if available)
    TreeFam Gene Tree for STOX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STOX1 gene
    STOX22  

    STOX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STOX1 (see all 1581)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs13416671,2,,4
    C,F,O,A,HPre-eclampsia/eclampsia 4 (PEE4)4 other171015682(-) TGGGTG/AATGTT 10 /H /Y mis1 tfbs338Minor allele frequency- A:0.35NA EA NS WA EU 6383
    rs412785321,2,,4
    C,FPre-eclampsia/eclampsia 4 (PEE4)4 --71019846(+) CCTAAA/TTTCAG 8 N I mis1 int12Minor allele frequency- T:0.01NA EU 1325
    VAR_0237844
    Pre-eclampsia/eclampsia 4 (PEE4)4--see VAR_0237842 R P mis40--------
    rs105093051,2,,4
    C,F,Hpathogenic171019196(+) TATGAA/CGTGTA 8 E D mis1 int1109Minor allele frequency- N:0.00NS EA NA PA EU CA WA CSA 8260
    rs15738391,2
    C,F--64588439(-) GCTCTT/CCGCAG 5 -- us2k18Minor allele frequency- C:0.35MN WA NA CSA EA 550
    rs16189321,2
    C,F,A--64588440(-) GGCTCC/TCCGCA 5 -- us2k14Minor allele frequency- T:0.02MN WA NA CSA 189
    rs612306521,2
    C--64600337(+) CTTTG-/AGAAAG 5 -- int11Minor allele frequency- A:0.50CSA 2
    rs113327001,2
    C--64603576(+) AGAGAT/-GGAAT 5 -- int11Minor allele frequency- -:0.50CSA 2
    rs24901661,2
    C--64610234(+) TTTTTA/TAAAAA 5 -- int13Minor allele frequency- T:0.22WA NA 240
    rs2003556951,2
    --64633743(+) TCTTT-/CTTTTT 5 -- int10--------

    HapMap Linkage Disequilibrium report for STOX1 (70587294 - 70655209 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STOX1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2590445CNV Deletion19546169
    dgv151e199CNV Deletion23128226
    esv2738073CNV Deletion23290073
    esv1719721CNV Deletion17803354
    esv1165433CNV Deletion17803354
    esv2738062CNV Deletion23290073
    nsv516725CNV Loss19592680
    nsv437688CNV Loss16327808
    nsv8685CNV Loss18304495
    esv25403CNV Loss19812545

    Human Gene Mutation Database (HGMD): STOX1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STOX1
    DNA2.0 Custom Variant and Variant Library Synthesis for STOX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609397   
    OMIM disorders: 609404  
    UniProtKB/Swiss-Prot: STOX1_HUMAN, Q6ZVD7
  • Pre-eclampsia/eclampsia 4 (PEE4) [MIM:609404]: A hypertensive disorder of pregnancy characterized by new
    hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant
    proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected.
    Preeclampsia is one of the causes of maternal mortality and morbidity worldwide. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 9 diseases for STOX1:    About MalaCards
    preeclampsia/eclampsia 4    eclampsia    pre-eclampsia    choriocarcinoma
    alzheimer's disease    hypertension    multiple myeloma    myeloma
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for STOX1:
    pre-eclampsia

    STOX1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): STOX1
    Human Genome Epidemiology (HuGE) Navigator: STOX1 (2 documents)

    Export disorders for STOX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STOX1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with STOX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family. (PubMed id 15806103)1, 2, 9 van Dijk M.... Oudejans C.B.M. (Nat. Genet. 2005)
    2. Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample. (PubMed id 17290274)1, 4 Kivinen K....Kere J. (Eur. J. Hum. Genet. 2007)
    3. STOX1 gene in pre-eclampsia and intrauterine growth restriction. (PubMed id 17617193)1, 4 Berends A.L....Steegers E.A. (BJOG 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    7. Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. (PubMed id 22993228)1 Williams F.M....Spector T.D. (Ann. Rheum. Dis. 2013)
    8. Transcription factor STOX1A promotes mitotic entry by binding to the CCNB1 promotor. (PubMed id 22253775)1 Abel D.v....Oudejans C.B. (PLoS ONE 2012)
    9. Direct downregulation of CNTNAP2 by STOX1A is associated with Alzheimer's disease. (PubMed id 22728895)1 van Abel D....Oudejans C.B. (J. Alzheimers Dis. 2012)
    10. STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease. (PubMed id 22995177)1 van Abel D....Oudejans C.B. (Neurosci. Lett. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 219736 HGNC: 23508 AceView: C10orf24 Ensembl:ENSG00000165730 euGenes: HUgn219736
    ECgene: STOX1 H-InvDB: STOX1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STOX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STOX1 gene:
    Search GeneIP for patents involving STOX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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