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STON2 Gene

protein-coding   GIFtS: 50
GCID: GC14M081736

Stonin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Stonin 21 2     Homolog Of Stoned B2
STN22 3 5     Stoned B Homolog 22
STNB2 3 5     stonin-22
Stoned B Homolog 2 (Drosophila)1     Stoned B3
STNB22     

External Ids:    HGNC: 306521   Entrez Gene: 854392   Ensembl: ENSG000001400227   OMIM: 6084675   UniProtKB: Q8WXE93   

Export aliases for STON2 gene to outside databases

Previous GC identifers: GC14M080807 GC14M061904


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STON2 Gene:
This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein
product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific
proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling
through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for STON2 Gene:
STON2 (stonin 2) is a protein-coding gene. Diseases associated with STON2 include schizophrenia, and obesity. An important paralog of this gene is GTF2A1L.

UniProtKB/Swiss-Prot: STON2_HUMAN, Q8WXE9
Function: Adapter protein involved in endocytic machinery. May be involved in the vesicle recycling. May
facilitate clathrin-coated vesicle uncoating




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STON2 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   Arnt   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTON2 promoter sequence
   Search Chromatin IP Primers for STON2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STON2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31.1   Ensembl cytogenetic band:  14q31.1   HGNC cytogenetic band: 14q31.1

STON2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STON2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M081736:  view genomic region     (about GC identifiers)

Start:
81,727,000 bp from pter      End:
81,902,809 bp from pter
Size:
175,810 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: STON2_HUMAN, Q8WXE9 (See protein sequence)
Recommended Name: Stonin-2  
Size: 905 amino acids; 101165 Da
Subunit: Interacts with the second C2 domain of synaptotagmins SYT1 and SYT2. Interacts with EPS15, EPS15R and
ITSN1. Interacts indirectly with the AP-2 adapter complex
Sequence caution: Sequence=AAK57558.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAK57558.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAK76362.1; Type=Frameshift;
Positions=122; Sequence=BAD92185.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for STON2:
2JXC (3D)    
Secondary accessions: G3V2T7 Q17R24 Q59H11 Q6NT47 Q96RI7 Q96RU6
Alternative splicing: 2 isoforms:  Q8WXE9-1   Q8WXE9-3   (No experimental confirmation available. Ref.3 (BAD92185) sequence is in conflict in position: 899:V->L)

Explore the universe of human proteins at neXtProt for STON2: NX_Q8WXE9

Explore proteomics data for STON2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STON2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243359.1  NP_149095.2  

    ENSEMBL proteins: 
     ENSP00000450857   ENSP00000450577   ENSP00000267540   ENSP00000450990   ENSP00000451383  

    STON2 Human Recombinant Protein Products:

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    Abcam antibodies for STON2
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    STON2 Assay Products:

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    Cloud-Clone Corp. CLIAs for STON2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR028565 MHD
     IPR008968 Clathrin_mu_C
     IPR027807 Stoned-like
     IPR012320 SHD
     IPR022699 Stonin2_N

    Graphical View of Domain Structure for InterPro Entry Q8WXE9

    ProtoNet protein and cluster: Q8WXE9

    UniProtKB/Swiss-Prot: STON2_HUMAN, Q8WXE9
    Domain: The Asn-Pro-Phe (NPF) motifs, which are found in proteins involved in the endocytic pathway, mediate the
    interaction with the EH domain of SYT1, SYT2, EPS15, EPS15R and ITSN1
    Similarity: Belongs to the Stoned B family
    Similarity: Contains 1 MHD (mu homology) domain
    Similarity: Contains 1 SHD (stonin homology) domain


    STON2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STON2_HUMAN, Q8WXE9
    Function: Adapter protein involved in endocytic machinery. May be involved in the vesicle recycling. May
    facilitate clathrin-coated vesicle uncoating

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11454741
         
    STON2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for STON2:
     Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ston2):
     behavior/neurological  nervous system 

    STON2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ston2tm1Vha for STON2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STON2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STON2

    miRNA
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    miRTarBase miRNAs that target STON2:
    hsa-mir-148b-3p (MIRT019363), hsa-mir-146a-5p (MIRT021263)

    Block miRNA regulation of human, mouse, rat STON2 using miScript Target Protectors
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STON2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STON2_HUMAN, Q8WXE9: Cytoplasm. Membrane. Note=Some fraction is membrane-associated
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0008021synaptic vesicle IEA--
    GO:0030131clathrin adaptor complex IEA--
    GO:0030136clathrin-coated vesicle ----

    STON2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STON2
    Interactions:

        GeneGlobe Interaction Network for STON2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STON2 (Q8WXE91, 2, 3 ENSP000002675404) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPS15P425661, 2, 3, ENSP000003607984EBI-539742,EBI-396684 MINT-6180038 MINT-6180111 MINT-6180129 MINT-6180018 MINT-6179779 MINT-6179905 MINT-6180093 MINT-6179941 MINT-6180075 MINT-6179996 MINT-6179890 MINT-6179923 MINT-6179875 MINT-6179857 MINT-6179977 MINT-6180056 I2D: score=4 STRING: ENSP00000360798
    EPS15L1Q9UBC22, 3, ENSP000002480704MINT-6180146 I2D: score=3 STRING: ENSP00000248070
    EHD1Q9H4M92, 3, ENSP000003205164MINT-6180161 I2D: score=1 STRING: ENSP00000320516
    NEDD8Q158432, 3, ENSP000002504954MINT-8092276 MINT-8092289 I2D: score=1 STRING: ENSP00000250495
    SYT1P215792, 3, ENSP000002612054MINT-6179779 I2D: score=3 STRING: ENSP00000261205
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006897endocytosis IEA--
    GO:0016192vesicle-mediated transport ----
    GO:0030100regulation of endocytosis ISS14726597

    STON2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STON2

    1 Novoseek inferred chemical compound relationship for STON2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 14.1 2 14726597 (1)



    STON2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STON2 gene (2 alternative transcripts): 
    NM_001256430.1  NM_033104.3  

    Unigene Cluster for STON2:

    Stonin 2
    Hs.14248  [show with all ESTs]
    Unigene Representative Sequence: NM_033104
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555447(uc001xvk.1) ENST00000553821 ENST00000555284(uc010tvt.2)
    ENST00000267540(uc010tvu.2) ENST00000556280 ENST00000555226(uc010atc.1)
    ENST00000557055 ENST00000554710
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STON2
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for STON2
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      QuantiTect SYBR Green Assays in human, mouse, rat STON2
      QuantiFast Probe-based Assays in human, mouse, rat STON2

    Additional mRNA sequence: 

    AB208948.1 AF255309.1 AF380833.1 AF449430.1 AK094799.1 AK309171.1 BC069359.1 BC069389.1 
    BC069502.1 BC069587.1 BC117493.1 BC117495.1 BX648249.1 

    10 DOTS entries:

    DT.100022341  DT.97816547  DT.91677889  DT.95332383  DT.109251  DT.92064265  DT.91668927  DT.404626 
    DT.312335  DT.91640997 

    Selected AceView cDNA sequences (see all 78):

    BM728825 BC069359 AI860620 N76626 BF934438 AI742489 BI018881 BX090979 
    AI991413 AF449430 BC069389 BM700378 BU742736 NM_033104 AF255309 BU681220 
    BG402869 AK094799 AA984839 BG403314 AI859804 BC069502 BX482291 BU738031 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for STON2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
    SP1:                    -     -     -                           
    SP2:                                -                           
    SP3:                                                            


    ECgene alternative splicing isoforms for STON2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STON2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTTGGAT
    STON2 Expression
    About this image

    STON2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STON2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.14248

    UniProtKB/Swiss-Prot: STON2_HUMAN, Q8WXE9
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STON2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STON2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ston21 , 5 stonin 21, 5 85.38(n)1
    88.75(a)1
      12 (45.02 cM)5
    1088001  NM_175367.61  NP_780576.11 
     916385425 
    chicken
    (Gallus gallus)
    Aves STON21 stonin 2 72.14(n)
    73.19(a)
      423390  XM_421302.3  XP_421302.2 
    lizard
    (Anolis carolinensis)
    Reptilia STON26
    stonin 2
    64(a)
    1 ↔ 1
    1(17791858-17879714)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc70h072 Transcribed sequence with weak similarity to protein more 75.76(n)    57051796 
    fruit fly
    (Drosophila melanogaster)
    Insecta stnB6
    stoned B
    16(a)
    1 → many
    X(22382558-22406483)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-416
    Protein UNC-41, isoform a (unc-41) mRNA, complete ...
    11(a)
    1 → many
    V(9966404-9976226) WBGene00006777


    ENSEMBL Gene Tree for STON2 (if available)
    TreeFam Gene Tree for STON2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STON2 gene
    GTF2A1L2  GTF2A12  STON12  STON1-GTF2A1L2  
    2 SIMAP similar genes for STON2 using alignment to 7 protein entries:     STON2_HUMAN (see all proteins):
    STON1    STON1-GTF2A1L

    STON2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STON2 (see all 3435)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1469887611,2
    C,Funtested181837403(+) TATACG/AAACAT 4 /S /L mis12Minor allele frequency- A:0.00NA EU 5875
    rs128805511,2
    C,F,H--81726571(+) CACAGG/ATACGC 2 -- int116Minor allele frequency- A:0.10NS EA NA WA 1964
    rs1145512881,2
    F--81726574(+) AGGTAC/TGCTGT 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1447263781,2
    --81726742(+) ATCTCG/TATCTC 2 -- int10--------
    rs758036471,2
    C--81726828(+) CTATCC/TTGAAT 2 -- int10--------
    rs1488932471,2
    --81726962(+) CTTCAC/TATGTC 2 -- int10--------
    rs1151210531,2
    F--81727014(+) TTTTTT/CATTAA 2 -- ut311Minor allele frequency- C:0.05WA 118
    rs1904940041,2
    --81727257(+) CACTGG/TATCTT 2 -- ut310--------
    rs1434560371,2
    --81727368(+) TTTGAC/TTAATC 2 -- ut310--------
    rs796938201,2
    C--81727383(+) GAATAC/TGGTAG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for STON2 (81727000 - 81902809 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for STON2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748931CNV Deletion23290073
    esv2748932CNV Deletion23290073
    esv270981CNV Insertion20981092
    esv273749CNV Insertion20981092
    esv1012064CNV Insertion17803354
    esv1001220CNV Insertion20482838
    nsv902119CNV Loss21882294
    nsv832841CNV Gain17160897

    Human Gene Mutation Database (HGMD): STON2
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing STON2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608467    OMIM disorders: --

    2 diseases for STON2:    About MalaCards
    schizophrenia    obesity


    STON2 for disorders           About GeneDecksing


    Export disorders for STON2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STON2 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with STON2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery. (PubMed id 11381094)1, 2, 3, 9 Martina J.A.... Bonifacino J.S. (J. Cell Biol. 2001)
    2. Human stoned B interacts with AP-2 and synaptotagmin and facilitates clathrin-coated vesicle uncoating. (PubMed id 11454741)1, 2, 3 Walther K.... Haucke V. (EMBO Rep. 2001)
    3. Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity. (PubMed id 18200045)1, 2 Rumpf J....Groemping Y. (EMBO J. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    6. Functional dissection of the interactions of stonin 2 with the adaptor complex AP-2 and synaptotagmin. (PubMed id 14726597)1, 9 Walther K....Haucke V. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    7. Stonin 2 is an AP-2-dependent endocytic sorting adaptor for synaptotagmin internalization and recycling. (PubMed id 16459302)1, 9 Diril M.K....Haucke V. (Dev. Cell 2006)
    8. Stonins--specialized adaptors for synaptic vesicle recycling and beyond? (PubMed id 19732400)1, 9 Maritzen T....Haucke V. (Traffic 2010)
    9. Cortical surface area correlates with STON2 gene Ser307Pro polymorphism in first-episode treatment-naA^ve patients with schizophrenia. (PubMed id 23785397)1 Xiang B....Hu X. (PLoS ONE 2013)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85439 HGNC: 30652 AceView: STN2 Ensembl:ENSG00000140022 euGenes: HUgn85439
    ECgene: STON2 H-InvDB: STON2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STON2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STON2 gene:
    Search GeneIP for patents involving STON2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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