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Aliases for STON1-GTF2A1L Gene

Aliases for STON1-GTF2A1L Gene

  • STON1-GTF2A1L Readthrough 2 3 5
  • Stoned B/TFIIA Alpha/Beta Like Factor 2
  • Stoned B/TFIIA-Alpha/Beta-Like Factor 3
  • SALF 3

External Ids for STON1-GTF2A1L Gene

Previous GeneCards Identifiers for STON1-GTF2A1L Gene

  • GC02P048650
  • GC02P048652
  • GC02P048653
  • GC02P048759
  • GC02P048762
  • GC02P048766
  • GC02P048769
  • GC02P048775
  • GC02P048778
  • GC02P048784
  • GC02P048787

Summaries for STON1-GTF2A1L Gene

Entrez Gene Summary for STON1-GTF2A1L Gene

  • STON1-GTF2A1L mRNAs are infrequent but naturally occurring read-through products of the neighboring STON1 and GTF2A1L genes. These transcripts encode fusion proteins composed of the vast majority of each of the individual elements, stonin 1 and general transcription factor IIA, 1-like. Alternative splicing results in multiple transcript variants. The significance of these read-through variants and the function of the resulting protein products have not yet been determined. [provided by RefSeq, Oct 2010]

GeneCards Summary for STON1-GTF2A1L Gene

STON1-GTF2A1L (STON1-GTF2A1L Readthrough) is a Protein Coding gene. An important paralog of this gene is GTF2A1L.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STON1-GTF2A1L Gene

Genomics for STON1-GTF2A1L Gene

Regulatory Elements for STON1-GTF2A1L Gene

Promoters for STON1-GTF2A1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STON1-GTF2A1L on UCSC Golden Path with GeneCards custom track

Genomic Location for STON1-GTF2A1L Gene

Chromosome:
2
Start:
48,529,925 bp from pter
End:
48,776,517 bp from pter
Size:
246,593 bases
Orientation:
Plus strand

Genomic View for STON1-GTF2A1L Gene

Genes around STON1-GTF2A1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STON1-GTF2A1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STON1-GTF2A1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STON1-GTF2A1L Gene

Proteins for STON1-GTF2A1L Gene

  • Protein details for STON1-GTF2A1L Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYG5
    Recommended name:
    Protein STON1-GTF2A1L
    Protein Accession:
    A0A0A6YYG5

    Protein attributes for STON1-GTF2A1L Gene

    Size:
    1135 amino acids
    Molecular mass:
    127325 Da
    Quaternary structure:
    No Data Available
  • Protein details for STON1-GTF2A1L Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYH4
    Recommended name:
    Protein STON1-GTF2A1L
    Protein Accession:
    A0A0A6YYH4

    Protein attributes for STON1-GTF2A1L Gene

    Size:
    1158 amino acids
    Molecular mass:
    129227 Da
    Quaternary structure:
    No Data Available
  • Protein details for STON1-GTF2A1L Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q53S48
    Recommended name:
    Protein STON1-GTF2A1L
    Protein Accession:
    Q53S48

    Protein attributes for STON1-GTF2A1L Gene

    Size:
    1182 amino acids
    Molecular mass:
    132083 Da
    Quaternary structure:
    No Data Available

neXtProt entry for STON1-GTF2A1L Gene

Proteomics data for STON1-GTF2A1L Gene at MOPED

Protein Expression for STON1-GTF2A1L Gene

Post-translational modifications for STON1-GTF2A1L Gene

No Post-translational modifications

Other Protein References for STON1-GTF2A1L Gene

No data available for DME Specific Peptides for STON1-GTF2A1L Gene

Domains & Families for STON1-GTF2A1L Gene

Protein Domains for STON1-GTF2A1L Gene

Suggested Antigen Peptide Sequences for STON1-GTF2A1L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STON1-GTF2A1L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for STON1-GTF2A1L Gene

Function for STON1-GTF2A1L Gene

Phenotypes for STON1-GTF2A1L Gene

genes like me logo Genes that share phenotypes with STON1-GTF2A1L: view

Animal Model Products

CRISPR Products

miRNA for STON1-GTF2A1L Gene

miRTarBase miRNAs that target STON1-GTF2A1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STON1-GTF2A1L Gene

Localization for STON1-GTF2A1L Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for STON1-GTF2A1L Gene

Pathways & Interactions for STON1-GTF2A1L Gene

SuperPathways for STON1-GTF2A1L Gene

No Data Available

Interacting Proteins for STON1-GTF2A1L Gene

Gene Ontology (GO) - Biological Process for STON1-GTF2A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with STON1-GTF2A1L: view

No data available for Pathways by source and SIGNOR curated interactions for STON1-GTF2A1L Gene

Drugs & Compounds for STON1-GTF2A1L Gene

No Compound Related Data Available

Transcripts for STON1-GTF2A1L Gene

Alternative Splicing Database (ASD) splice patterns (SP) for STON1-GTF2A1L Gene

No ASD Table

Relevant External Links for STON1-GTF2A1L Gene

GeneLoc Exon Structure for
STON1-GTF2A1L
ECgene alternative splicing isoforms for
STON1-GTF2A1L

Expression for STON1-GTF2A1L Gene

mRNA expression in normal human tissues for STON1-GTF2A1L Gene

mRNA differential expression in normal tissues according to GTEx for STON1-GTF2A1L Gene

This gene is overexpressed in Colon - Sigmoid (x7.6), Esophagus - Gastroesophageal Junction (x6.3), Esophagus - Muscularis (x5.2), and Bladder (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB for STON1-GTF2A1L Gene



genes like me logo Genes that share expression patterns with STON1-GTF2A1L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for STON1-GTF2A1L Gene

Orthologs for STON1-GTF2A1L Gene

This gene was present in the common ancestor of animals.

Orthologs for STON1-GTF2A1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia GTF2A1L 36
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ston1 36
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia STON1 36
  • 73 (a)
OneToMany
chicken
(Gallus gallus)
Aves STON1 36
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii gtf2a1l 36
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta stnB 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-41 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5149 36
  • 25 (a)
OneToMany
Species with no ortholog for STON1-GTF2A1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for STON1-GTF2A1L Gene

ENSEMBL:
Gene Tree for STON1-GTF2A1L (if available)
TreeFam:
Gene Tree for STON1-GTF2A1L (if available)

Paralogs for STON1-GTF2A1L Gene

Paralogs for STON1-GTF2A1L Gene

(4) SIMAP similar genes for STON1-GTF2A1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STON1-GTF2A1L: view

Variants for STON1-GTF2A1L Gene

Sequence variations from dbSNP and Humsavar for STON1-GTF2A1L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1404051 -- 48,683,977(-) CCTTG(G/T)CTTCC intron-variant
rs1524150 -- 48,681,564(-) AAATT(A/C)TTATT intron-variant
rs2177486 -- 48,605,323(+) GATCA(A/G)CACAA intron-variant
rs4245817 -- 48,614,441(+) CGGAC(C/T)GGGTG intron-variant
rs4245820 -- 48,769,405(+) AGGAC(A/G)GCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STON1-GTF2A1L Gene

Variant ID Type Subtype PubMed ID
nsv833981 CNV Loss 17160897
esv2631205 CNV Deletion 19546169
esv990475 CNV Deletion 20482838
esv2354047 CNV Deletion 18987734
esv2720033 CNV Deletion 23290073
esv3660 CNV Deletion 18987735
esv8396 CNV Loss 19470904
esv2678523 CNV Deletion 23128226
esv1633121 CNV Deletion 17803354
esv2720034 CNV Deletion 23290073
esv1496764 CNV Deletion 17803354
esv1298688 CNV Deletion 17803354
nsv829197 CNV Gain 20364138
nsv833992 CNV Gain 17160897
esv275164 CNV Gain+Loss 21479260
nsv874004 CNV Loss 21882294
nsv2719 CNV Loss 18451855
esv991713 CNV Deletion 20482838
esv2720035 CNV Deletion 23290073
esv2676191 CNV Deletion 23128226
esv997251 CNV Loss 20482838
esv24510 CNV Loss 19812545
nsv817851 CNV Gain 17921354
esv2668681 CNV Deletion 23128226

Variation tolerance for STON1-GTF2A1L Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.79; 95.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STON1-GTF2A1L Gene

HapMap Linkage Disequilibrium report
STON1-GTF2A1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STON1-GTF2A1L Gene

Disorders for STON1-GTF2A1L Gene

Relevant External Links for STON1-GTF2A1L

Genetic Association Database (GAD)
STON1-GTF2A1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STON1-GTF2A1L

No disorders were found for STON1-GTF2A1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STON1-GTF2A1L Gene

Publications for STON1-GTF2A1L Gene

  1. Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis. (PMID: 10364255) Upadhyaya A.B. … DeJong J. (J. Biol. Chem. 1999) 2 3 23 67
  2. TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general transcription factors during spermatogenesis in the mouse. (PMID: 11159353) Han S. … DeJong J. (Biol. Reprod. 2001) 2 3
  3. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T. … Xu R. (Neurobiol. Aging 2014) 3
  4. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. (PMID: 22885925) Shi Y. … Chen Z.J. (Nat. Genet. 2012) 3
  5. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. (PMID: 21151128) Chen Z.J. … Zhao Y. (Nat. Genet. 2011) 3

Products for STON1-GTF2A1L Gene

Sources for STON1-GTF2A1L Gene

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