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STON1 Gene

protein-coding   GIFtS: 42
GCID: GC02P048788

Stonin 1

  Search for STON1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Stonin 11 2     Stoned B Homolog 1 (Drosophila)1
SALF2 3 5     STNB12
SBLF2 3 5     Stoned B Homolog 12
STN12 3 5     stoned-b12
Stoned B-Like Factor2 3     stonin-12

External Ids:    HGNC: 170031   Entrez Gene: 110372   Ensembl: ENSG000002432447   OMIM: 6053575   UniProtKB: Q9Y6Q23   

Export aliases for STON1 gene to outside databases

Previous GC identifers: GC02P048661 GC02P048611 GC02P048760 GC02P048763 GC02P048767 GC02P048773 GC02P048776 GC02P048779 GC02P048785


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STON1 Gene:
Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner
surface of the plasma membrane. This gene encodes one of two human homologs of the Drosophila melanogaster stoned
B protein. This protein is related to components of the endocytic machinery and exhibits a modular structure
consisting of an N-terminal proline-rich domain, a central region of homology specific to the human stoned B-like
proteins, and a C-terminal region homologous to the mu subunits of adaptor protein (AP) complexes. Read-through
transcription of this gene into the neighboring downstream gene, which encodes TFIIA-alpha/beta-like factor,
generates a transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each
individual gene product. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Oct
2010)

GeneCards Summary for STON1 Gene:
STON1 (stonin 1) is a protein-coding gene. An important paralog of this gene is STON2.

UniProtKB/Swiss-Prot: STON1_HUMAN, Q9Y6Q2
Function: May be involved in the endocytic machinery (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the STON1 gene promoter:
         c-Fos   Sox5   AML1a   AP-1   LCR-F1   HNF-3beta   HNF-1A   PPAR-alpha   HNF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTON1 promoter sequence
   Search Chromatin IP Primers for STON1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STON1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.3   Ensembl cytogenetic band:  2p16.3   HGNC cytogenetic band: 2p16.3

STON1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STON1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P048788:  view genomic region     (about GC identifiers)

Start:
48,756,522 bp from pter      End:
48,826,025 bp from pter
Size:
69,504 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: STON1_HUMAN, Q9Y6Q2 (See protein sequence)
Recommended Name: Stonin-1  
Size: 735 amino acids; 83141 Da
Miscellaneous: In contrast to other members of the family, it does not contain NPF (Asn-Pro-Phe) sites and thereby
does not interact with EPS15, EPS15R and ITSN1
Sequence caution: Sequence=AAD39617.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. The biological
existence and relevance of this product of both SALF and GTF2A1LF (AC Q9UNN4) genes, which codes for a chimeric
protein of 1182 residues is uncertain;
Secondary accessions: A8MXJ1 B5MCF5 B7ZL16 Q96JE3 Q9BYX3
Alternative splicing: 3 isoforms:  Q9Y6Q2-1   Q9Y6Q2-2   Q9Y6Q2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STON1: NX_Q9Y6Q2

Explore proteomics data for STON1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STON1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001185524.1  NP_006864.2  

    ENSEMBL proteins: 
     ENSP00000385273   ENSP00000384615   ENSP00000399868   ENSP00000310969  

    STON1 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for STON1

    STON1 Assay Products:

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    Cloud-Clone Corp. CLIAs for STON1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR028565 MHD
     IPR008968 Clathrin_mu_C
     IPR027807 Stoned-like
     IPR012320 SHD
     IPR017110 Stonin

    Graphical View of Domain Structure for InterPro Entry Q9Y6Q2

    ProtoNet protein and cluster: Q9Y6Q2

    1 Blocks protein domain: IPB004855 Transcription factor IIA

    UniProtKB/Swiss-Prot: STON1_HUMAN, Q9Y6Q2
    Similarity: Belongs to the Stoned B family
    Similarity: Contains 1 MHD (mu homology) domain
    Similarity: Contains 1 SHD (stonin homology) domain


    STON1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STON1_HUMAN, Q9Y6Q2
    Function: May be involved in the endocytic machinery (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    STON1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STON1
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate STON1 (see all 25):
    hsa-miR-576-3p hsa-miR-16-2* hsa-miR-4328 hsa-miR-520d-5p hsa-miR-3942-5p hsa-miR-421 hsa-miR-499-5p hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidSTON1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STON1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STON1_HUMAN, Q9Y6Q2: Cytoplasm. Membrane. Note=Some fraction is membrane-associated
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030131clathrin adaptor complex IEA--

    STON1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STON1
    Interactions:

        Search GeneGlobe Interaction Network for STON1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STON1 (ENSP000003109694) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AFTPHENSP000002388554STRING: ENSP00000238855
    AP1B1ENSP000003501994STRING: ENSP00000350199
    AP1G1ENSP000003771484STRING: ENSP00000377148
    AP1G2ENSP000003124424STRING: ENSP00000312442
    AP1M1ENSP000003889964STRING: ENSP00000388996
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006897endocytosis IEA--
    GO:0016192vesicle-mediated transport ----
    GO:0030100regulation of endocytosis IDA11454741

    STON1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STON1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STON1 gene (2 alternative transcripts): 
    NM_001198595.1  NM_006873.3  

    Unigene Cluster for STON1:

    Stonin 1
    Hs.44385  [show with all ESTs]
    Unigene Representative Sequence: AK023617
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484110 ENST00000404752(uc010fbm.3) ENST00000406226(uc002rwo.4)
    ENST00000444932 ENST00000309835
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate STON1 (see all 25):
    hsa-miR-576-3p hsa-miR-16-2* hsa-miR-4328 hsa-miR-520d-5p hsa-miR-3942-5p hsa-miR-421 hsa-miR-499-5p hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidSTON1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STON1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat STON1
      QuantiTect SYBR Green Assays in human, mouse, rat STON1
      QuantiFast Probe-based Assays in human, mouse, rat STON1

    Additional mRNA sequence: 

    AK023617.1 AL080210.1 

    2 DOTS entries:

    DT.70104014  DT.112774 

    Selected AceView cDNA sequences (see all 139):

    NM_006872 BM676739 AY026319 BU738931 CN480994 BC025991 AW294274 CD558013 
    BF792128 AU138011 AW068983 CR604481 BP374692 AF255310 AA366842 NM_172196 
    BF436701 AW129964 AA496951 NM_172311 NM_006873 AK023617 CA419207 BQ639031 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STON1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    STON1 Expression
    About this image

    STON1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STON1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.44385

    UniProtKB/Swiss-Prot: STON1_HUMAN, Q9Y6Q2
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STON1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STON1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ston11 , 5 stonin 11, 5 80.22(n)1
    77.34(a)1
      17 (58.10 cM)5
    770571  NM_029858.21  NP_084134.21 
     885976845 
    chicken
    (Gallus gallus)
    Aves STON11 stonin 1 68.69(n)
    67.68(a)
      100534590  NM_001204865.2  NP_001191794.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    60(a)
    1 → many
    1(255548147-255564441)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ston11 stonin 1 61.6(n)
    57.52(a)
      100493990  NM_001204867.1  NP_001191796.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gtf2a1l6
    general transcription factor IIA, 1-like
    23(a)
    1 → many
    13(91414-100201) ENSDARG00000063670
    fruit fly
    (Drosophila melanogaster)
    Insecta stnB6
    stoned B
    12(a)
    1 → many
    X(22382558-22406483)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-416
    Protein UNC-41, isoform a (unc-41) mRNA, complete ...
    9(a)
    1 → many
    V(9966404-9976226) WBGene00006777


    ENSEMBL Gene Tree for STON1 (if available)
    TreeFam Gene Tree for STON1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STON1 gene
    STON22  GTF2A1L2  GTF2A12  STON1-GTF2A1L2  
    3 SIMAP similar genes for STON1 using alignment to 4 protein entries:     STON1_HUMAN (see all proteins):
    ALF    STON1-GTF2A1L    STON2

    STON1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    4 SNPs for STON1    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs9403891,2,4
    ----see VAR_0201832 mis40--------
    rs38283411,2,4
    ----see VAR_0201842 mis40--------
    rs170392501,2,4
    ----see VAR_0521562 mis40--------
    rs37922341,2,4
    ----see VAR_0201852 mis40--------

    HapMap Linkage Disequilibrium report for STON1 (48756522 - 48826025 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STON1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2631205CNV Deletion19546169
    esv3660CNV Deletion18987735
    esv990475CNV Deletion20482838
    esv1496764CNV Deletion17803354
    esv2720033CNV Deletion23290073
    esv2678523CNV Deletion23128226
    esv1298688CNV Deletion17803354
    esv2354047CNV Deletion18987734
    esv2720034CNV Deletion23290073
    esv1633121CNV Deletion17803354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STON1
    DNA2.0 Custom Variant and Variant Library Synthesis for STON1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605357    OMIM disorders: --


    STON1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): STON1

    Export disorders for STON1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STON1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with STON1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis. (PubMed id 10364255)1, 2, 3 Upadhyaya A.B.... DeJong J. (J. Biol. Chem. 1999)
    2. Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery. (PubMed id 11381094)1, 2, 9 Martina J.A.... Bonifacino J.S. (J. Cell Biol. 2001)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Functional dissection of a eukaryotic dicistronic gene: transgenic stonedB, but not stonedA, restores normal synaptic properties to Drosophila stoned mutants. (PubMed id 14504226)1, 3 Estes P.S....Ramaswami M. (Genetics 2003)
    5. TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general transcription factors during spermatogenesis in the mouse. (PubMed id 11159353)1, 2 Han S.... DeJong J. (Biol. Reprod. 2001)
    6. Stonins--specialized adaptors for synaptic vesicle recycling and beyond? (PubMed id 19732400)1, 9 Maritzen T....Haucke V. (Traffic 2010)
    7. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11037 HGNC: 17003 AceView: ALF Ensembl:ENSG00000243244 euGenes: HUgn11037
    ECgene: STON1 H-InvDB: STON1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STON1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STON1 gene:
    Search GeneIP for patents involving STON1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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