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Aliases for STOML3 Gene

Aliases for STOML3 Gene

  • Stomatin Like 3 2 3 5
  • Stomatin (EPB72)-Like 3 2 3
  • EPB72-Like 3 2 3
  • SLP-3 3 4
  • Erythrocyte Band 7 Integral Membrane Protein 3
  • Stomatin-Like Protein 3 3
  • Protein 7.2b 3
  • Epb7.2l 3
  • SRO 3

External Ids for STOML3 Gene

Previous GeneCards Identifiers for STOML3 Gene

  • GC13M033526
  • GC13M038476
  • GC13M037338
  • GC13M038438
  • GC13M039540
  • GC13M020339

Summaries for STOML3 Gene

GeneCards Summary for STOML3 Gene

STOML3 (Stomatin Like 3) is a Protein Coding gene. Diseases associated with STOML3 include Gliosarcoma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. An important paralog of this gene is STOM.

UniProtKB/Swiss-Prot for STOML3 Gene

  • Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STOML3 Gene

Genomics for STOML3 Gene

Regulatory Elements for STOML3 Gene

Enhancers for STOML3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G039035 1.1 ENCODE 6 -47.3 -47308 5.8 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 SIN3A DMAP1 ZNF2 YY1 LHFP NHLRC3 STOML3 LOC105370169
GH13G039022 0.8 ENCODE 7.1 -33.6 -33589 4.5 CTCF PKNOX1 SIN3A FEZF1 CEBPG RBBP5 RAD21 ZIC2 ZNF664 CTBP1 STOML3 LHFP PROSER1 GC13M038977
GH13G038979 0.7 ENCODE 6.3 +10.5 10458 2.1 MXI1 HLF REST CEBPG EP300 ZNF589 POLR2A SMARCA4 ZNF547 ZNF584 NHLRC3 PROSER1 STOML3 LHFP GC13P038946
GH13G038951 0.6 ENCODE 0.3 +39.3 39308 0.2 ZBTB21 ZBTB48 SCRT2 ZNF629 ZNF350 CEBPG FEZF1 ZNF398 GC13P038946 STOML3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STOML3 on UCSC Golden Path with GeneCards custom track

Genomic Location for STOML3 Gene

Chromosome:
13
Start:
38,965,925 bp from pter
End:
38,991,066 bp from pter
Size:
25,142 bases
Orientation:
Minus strand

Genomic View for STOML3 Gene

Genes around STOML3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STOML3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STOML3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STOML3 Gene

Proteins for STOML3 Gene

  • Protein details for STOML3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAV4-STML3_HUMAN
    Recommended name:
    Stomatin-like protein 3
    Protein Accession:
    Q8TAV4
    Secondary Accessions:
    • B4E285
    • Q5JS35

    Protein attributes for STOML3 Gene

    Size:
    291 amino acids
    Molecular mass:
    32135 Da
    Quaternary structure:
    • Homodimer. Interacts with PIEZO1 and PIEZO2.

    Alternative splice isoforms for STOML3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STOML3 Gene

Post-translational modifications for STOML3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STOML3 Gene

No data available for DME Specific Peptides for STOML3 Gene

Domains & Families for STOML3 Gene

Protein Domains for STOML3 Gene

Suggested Antigen Peptide Sequences for STOML3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TAV4

UniProtKB/Swiss-Prot:

STML3_HUMAN :
  • Belongs to the band 7/mec-2 family.
Family:
  • Belongs to the band 7/mec-2 family.
genes like me logo Genes that share domains with STOML3: view

No data available for Gene Families for STOML3 Gene

Function for STOML3 Gene

Molecular function for STOML3 Gene

UniProtKB/Swiss-Prot Function:
Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.

Gene Ontology (GO) - Molecular Function for STOML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with STOML3: view
genes like me logo Genes that share phenotypes with STOML3: view

Animal Models for STOML3 Gene

MGI Knock Outs for STOML3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STOML3 Gene

Localization for STOML3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STOML3 Gene

Cell membrane; Single-pass type III membrane protein. Note=Detected in lipid rafts. {ECO:0000250 UniProtKB:Q6PE84}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STOML3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for STOML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane TAS --
GO:0005929 cilium IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STOML3: view

Pathways & Interactions for STOML3 Gene

genes like me logo Genes that share pathways with STOML3: view

Pathways by source for STOML3 Gene

Gene Ontology (GO) - Biological Process for STOML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0008150 biological_process ND --
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with STOML3: view

No data available for SIGNOR curated interactions for STOML3 Gene

Drugs & Compounds for STOML3 Gene

No Compound Related Data Available

Transcripts for STOML3 Gene

mRNA/cDNA for STOML3 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for STOML3 Gene

Stomatin (EPB72)-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STOML3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for STOML3 Gene

GeneLoc Exon Structure for
STOML3
ECgene alternative splicing isoforms for
STOML3

Expression for STOML3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STOML3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STOML3 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x8.2), Brain - Hippocampus (x8.0), Brain - Hypothalamus (x7.9), Cervix - Endocervix (x7.8), Fallopian Tube (x7.4), and Lung (x4.4).

Protein differential expression in normal tissues from HIPED for STOML3 Gene

This gene is overexpressed in Adipocyte (63.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STOML3 Gene



Protein tissue co-expression partners for STOML3 Gene

NURSA nuclear receptor signaling pathways regulating expression of STOML3 Gene:

STOML3

SOURCE GeneReport for Unigene cluster for STOML3 Gene:

Hs.327794

Evidence on tissue expression from TISSUES for STOML3 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with STOML3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STOML3 Gene

Orthologs for STOML3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STOML3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STOML3 34 35
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia STOML3 34 35
  • 90.15 (n)
cow
(Bos Taurus)
Mammalia STOML3 34 35
  • 89.72 (n)
oppossum
(Monodelphis domestica)
Mammalia STOML3 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stoml3 34 16 35
  • 85.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STOML3 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves STOML3 34 35
  • 74.25 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia stoml3 34
  • 65.33 (n)
zebrafish
(Danio rerio)
Actinopterygii stoml3a 34 35
  • 63.48 (n)
stoml3b 35
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG42540 35
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sto-2 35
  • 45 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU03388 34
  • 47.18 (n)
Species where no ortholog for STOML3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STOML3 Gene

ENSEMBL:
Gene Tree for STOML3 (if available)
TreeFam:
Gene Tree for STOML3 (if available)

Paralogs for STOML3 Gene

Paralogs for STOML3 Gene

(3) SIMAP similar genes for STOML3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STOML3: view

Variants for STOML3 Gene

Sequence variations from dbSNP and Humsavar for STOML3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000220299 -- 38,974,232(+) ATTTC(C/T)ATTAA intron-variant
rs1000268875 -- 38,980,645(+) GTTGT(C/T)GCATA intron-variant
rs1000454134 -- 38,986,315(+) CAGGC(A/C)TGAGC intron-variant
rs1000495020 -- 38,975,461(+) GAGCA(A/T)CGTGG intron-variant
rs1000535114 -- 38,972,728(+) TGAAA(C/G)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STOML3 Gene

Variant ID Type Subtype PubMed ID
esv1348054 CNV insertion 17803354
esv3328890 CNV insertion 20981092
nsv1069746 CNV deletion 25765185
nsv509503 CNV insertion 20534489

Variation tolerance for STOML3 Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STOML3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STOML3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STOML3 Gene

Disorders for STOML3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STOML3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gliosarcoma
  • glioblastoma with sarcomatous component
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for STOML3

Genetic Association Database (GAD)
STOML3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STOML3
genes like me logo Genes that share disorders with STOML3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STOML3 Gene

Publications for STOML3 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Stomatin-related olfactory protein, SRO, specifically expressed in the murine olfactory sensory neurons. (PMID: 12122055) Kobayakawa K. … Sakano H. (J. Neurosci. 2002) 2 3 64
  4. Amplification of the STOML3, FREM2, and LHFP genes is associated with mesenchymal differentiation in gliosarcoma. (PMID: 22538188) Nagaishi M. … Ohgaki H. (Am. J. Pathol. 2012) 3 64
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64

Products for STOML3 Gene

Sources for STOML3 Gene

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