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Aliases for STOML3 Gene

Aliases for STOML3 Gene

  • Stomatin (EPB72)-Like 3 2 3
  • SLP-3 3 4
  • SRO 3 6
  • Erythrocyte Band 7 Integral Membrane Protein 3
  • Stomatin-Like Protein 3 3
  • Protein 7.2b 3
  • Epb7.2l 3

External Ids for STOML3 Gene

Summaries for STOML3 Gene

GeneCards Summary for STOML3 Gene

STOML3 (Stomatin (EPB72)-Like 3) is a Protein Coding gene. Diseases associated with STOML3 include mesenchymal cell neoplasm. An important paralog of this gene is STOML2.

UniProtKB/Swiss-Prot for STOML3 Gene

  • Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STOML3 Gene

Genomics for STOML3 Gene

Genomic Location for STOML3 Gene

Start:
38,965,925 bp from pter
End:
38,991,066 bp from pter
Size:
25,142 bases
Orientation:
Minus strand

Genomic View for STOML3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STOML3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STOML3 Gene

Regulatory Elements for STOML3 Gene

Proteins for STOML3 Gene

  • Protein details for STOML3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAV4-STML3_HUMAN
    Recommended name:
    Stomatin-like protein 3
    Protein Accession:
    Q8TAV4
    Secondary Accessions:
    • B4E285
    • Q5JS35

    Protein attributes for STOML3 Gene

    Size:
    291 amino acids
    Molecular mass:
    32135 Da
    Quaternary structure:
    • Homodimer. Interacts with PIEZO1 and PIEZO2.

    Alternative splice isoforms for STOML3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STOML3 Gene

Proteomics data for STOML3 Gene at MOPED

Post-translational modifications for STOML3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STOML3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STOML3 Gene

Domains for STOML3 Gene

Protein Domains for STOML3 Gene

Suggested Antigen Peptide Sequences for STOML3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TAV4

UniProtKB/Swiss-Prot:

STML3_HUMAN
Family:
  • Belongs to the band 7/mec-2 family.:
    • Q8TAV4
genes like me logo Genes that share domains with STOML3: view

No data available for Gene Families for STOML3 Gene

Function for STOML3 Gene

Molecular function for STOML3 Gene

UniProtKB/Swiss-Prot Function: Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.

Gene Ontology (GO) - Molecular Function for STOML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with STOML3: view

Phenotypes for STOML3 Gene

genes like me logo Genes that share phenotypes with STOML3: view

Animal Models for STOML3 Gene

MGI Knock Outs for STOML3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for STOML3 Gene

Localization for STOML3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STOML3 Gene

Cell membrane; Single-pass type III membrane protein. Note=Detected in lipid rafts. {ECO:0000250 UniProtKB:Q6PE84}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STOML3 Gene COMPARTMENTS Subcellular localization image for STOML3 gene
Compartment Confidence
plasma membrane 5
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for STOML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane IEA --
GO:0005929 cilium IEA --
GO:0016021 integral component of membrane IEA --
GO:0045121 membrane raft IEA --
genes like me logo Genes that share ontologies with STOML3: view

Pathways for STOML3 Gene

SuperPathways for STOML3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STOML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with STOML3: view

No data available for Pathways by source for STOML3 Gene

Transcripts for STOML3 Gene

mRNA/cDNA for STOML3 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for STOML3 Gene

Stomatin (EPB72)-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STOML3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for STOML3 Gene

GeneLoc Exon Structure for
STOML3
ECgene alternative splicing isoforms for
STOML3

Expression for STOML3 Gene

mRNA expression in normal human tissues for STOML3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STOML3 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (8.2), Brain - Hippocampus (8.0), Brain - Hypothalamus (7.9), Cervix - Endocervix (7.8), Fallopian Tube (7.4), and Lung (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for STOML3 Gene

SOURCE GeneReport for Unigene cluster for STOML3 Gene Hs.327794

genes like me logo Genes that share expressions with STOML3: view

No data available for mRNA Expression by UniProt/SwissProt for STOML3 Gene

Orthologs for STOML3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STOML3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STOML3 35
  • 99.31 (n)
  • 100 (a)
STOML3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STOML3 35
  • 89.72 (n)
  • 94.07 (a)
STOML3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STOML3 35
  • 90.15 (n)
  • 93.13 (a)
STOML3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stoml3 35
  • 85.83 (n)
  • 91.99 (a)
Stoml3 16
Stoml3 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STOML3 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STOML3 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves STOML3 35
  • 74.25 (n)
  • 76.53 (a)
STOML3 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stoml3 35
  • 65.33 (n)
  • 67.52 (a)
zebrafish
(Danio rerio)
Actinopterygii stoml3a 35
  • 63.48 (n)
  • 64.94 (a)
stoml3a 36
  • 54 (a)
OneToMany
stoml3b 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG42540 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sto-2 36
  • 45 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU03388 35
  • 47.18 (n)
  • 33.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
Species with no ortholog for STOML3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STOML3 Gene

ENSEMBL:
Gene Tree for STOML3 (if available)
TreeFam:
Gene Tree for STOML3 (if available)

Paralogs for STOML3 Gene

Paralogs for STOML3 Gene

Selected SIMAP similar genes for STOML3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STOML3: view

Variants for STOML3 Gene

Sequence variations from dbSNP and Humsavar for STOML3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs943225 -- 38,981,592(-) ATGAT(A/G)ACACA intron-variant
rs1109625 -- 38,979,564(-) TTAAA(A/G)TAGAA intron-variant
rs1926474 -- 38,984,077(-) GGTTG(C/T)GGCTG intron-variant
rs3064520 -- 38,991,585(+) ttttt(-/TTT)gagat upstream-variant-2KB
rs3922615 -- 38,975,178(+) TAGCC(A/G)CTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STOML3 Gene

Variant ID Type Subtype PubMed ID
nsv509503 CNV Insertion 20534489
esv1348054 CNV Insertion 17803354

Relevant External Links for STOML3 Gene

HapMap Linkage Disequilibrium report
STOML3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STOML3 Gene

Disorders for STOML3 Gene

(1) MalaCards Diseases for STOML3 Gene

Search for STOML3 Gene in MalaCards »

(3) University of Copenhagen DISEASES for STOML3 Gene

Relevant External Links for STOML3

Genetic Association Database (GAD)
STOML3
genes like me logo Genes that share disorders with STOML3: view

No data available for UniProtKB/Swiss-Prot for STOML3 Gene

Publications for STOML3 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Stomatin-related olfactory protein, SRO, specifically expressed in the murine olfactory sensory neurons. (PMID: 12122055) Kobayakawa K. … Sakano H. (J. Neurosci. 2002) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for STOML3 Gene

Sources for STOML3 Gene

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