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STOML2 Gene

protein-coding   GIFtS: 55
GCID: GC09M035099

Stomatin (EPB72)-Like 2

  See STOML2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Stomatin (EPB72)-Like 21 2     Stomatin-Like 22
Paraprotein Target 72 3     Stomatin-Like Protein 2, Mitochondrial2
SLP-22 3     Paratarg-73
EPB72-Like Protein 22 3     SLP23
paratarg-72     

External Ids:    HGNC: 145591   Entrez Gene: 309682   Ensembl: ENSG000001652837   OMIM: 6082925   UniProtKB: Q9UJZ13   

Export aliases for STOML2 gene to outside databases

Previous GC identifers: GC09M035412 GC09M035269 GC09M035089


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STOML2 Gene:
STOML2 (stomatin (EPB72)-like 2) is a protein-coding gene. Diseases associated with STOML2 include acromesomelic dysplasia. GO annotations related to this gene include cardiolipin binding and receptor binding. An important paralog of this gene is STOML3.

UniProtKB/Swiss-Prot: STML2_HUMAN, Q9UJZ1
Function: Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria.
Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some
proteins including prohibitin and may therefore act in the organization of functional microdomains in
mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological
processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular
response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from
mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in
increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma
membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and
its regulation

Gene Wiki entry for STOML2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the STOML2 gene promoter:
         Egr-3   USF1   RFX1   Pax-5   STAT5A   XBP-1   GATA-1   AREB6   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTOML2 promoter sequence
   Search Chromatin IP Primers for STOML2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STOML2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.1   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.1

STOML2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STOML2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M035099:  view genomic region     (about GC identifiers)

Start:
35,099,888 bp from pter      End:
35,103,154 bp from pter
Size:
3,267 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STML2_HUMAN, Q9UJZ1 (See protein sequence)
Recommended Name: Stomatin-like protein 2, mitochondrial precursor  
Size: 356 amino acids; 38534 Da
Subunit: Forms homooligomers. Interacts with MFN2; may form heterooligomers. Interacts with CACNA2D2 (By
similarity). Interacts with PHB and PHB2; recruits them to cardiolipin-enriched mitochondrial membranes and
stabilizes them
Miscellaneous: Paratarg-7/STOML2 is a frequent autoantigenic target in monoclonal gammopathy of undetermined
significance (MGUS), multiple myeloma (MM) and Waldenstrom macroglobulinemia, 3 B-cell neoplasms associated with
excessive secretion of a single monoclonal gammaglobulin (also named paraprotein) in the blood (PubMed:19405124)
Sequence caution: Sequence=AAC07983.1; Type=Erroneous gene model prediction; Sequence=AAF29073.1; Type=Frameshift;
Positions=14, 26;
Secondary accessions: D3DRN3 O60376 Q53G29 Q96FY2 Q9P042

Explore the universe of human proteins at neXtProt for STOML2: NX_Q9UJZ1

Explore proteomics data for STOML2 at MOPED

Post-translational modifications: 

  • Hyperphosphorylated at Ser-17 in some patients with monoclonal gammopathy of undetermined significance (MGUS),
    multiple myeloma (MM) and Waldenstrom macroglobulinemia due to impaired dephosphorylation by PP2A1
  • Ubiquitination2 at Lys140, Lys145
  • Modification sites at PhosphoSitePlus

  • See STOML2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001273960.1  NP_001273961.1  NP_001273962.1  NP_038470.1  

    ENSEMBL proteins: 
     ENSP00000348886   ENSP00000434531   ENSP00000395743  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR028520 SLP2
     IPR001107 Band_7
     IPR001972 Stomatin_fam

    Graphical View of Domain Structure for InterPro Entry Q9UJZ1

    ProtoNet protein and cluster: Q9UJZ1

    1 Blocks protein domain: IPB001972 Stomatin

    UniProtKB/Swiss-Prot: STML2_HUMAN, Q9UJZ1
    Similarity: Belongs to the band 7/mec-2 family


    Find genes that share domains with STOML2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STML2_HUMAN, Q9UJZ1
    Function: Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria.
    Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some
    proteins including prohibitin and may therefore act in the organization of functional microdomains in
    mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological
    processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular
    response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from
    mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in
    increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma
    membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and
    its regulation
    Induction: Up-regulated in activated B- and T-cells and upon mitochondrial stress by chloramphenicol

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS10713127
    GO:0005515protein binding IPI17121834
    GO:1901612cardiolipin binding IDA--
         
    Find genes that share ontologies with STOML2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Stoml2):
     immune system 

    Find genes that share phenotypes with STOML2           About GenesLikeMe

    Animal Models:
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    miRTarBase miRNAs that target STOML2:
    hsa-mir-423-3p (MIRT042553), hsa-mir-26b-5p (MIRT029840), hsa-mir-31-5p (MIRT049902), hsa-mir-320a (MIRT044836), hsa-mir-615-3p (MIRT040042), hsa-mir-187-3p (MIRT047030)

    Block miRNA regulation of human, mouse, rat STOML2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate STOML2:
    hsa-miR-3671
    SwitchGear 3'UTR luciferase reporter plasmidSTOML2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STML2_HUMAN, Q9UJZ1: Mitochondrion inner membrane. Mitochondrion intermembrane space. Cell membrane; Peripheral
    membrane protein. Membrane raft; Peripheral membrane protein. Note=Behaves as an integral membrane protein of the
    mitochondrion despite the absence of a detectable transmembrane domain. A minor pool is associated with the
    plasma membrane and is enriched at the immunological synapse in activated T-cells. Also associates with the actin
    cytoskeleton and membrane rafts in activated T-cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    plasma membrane5
    cytoskeleton4
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772colocalizes with immunological synapse IDA--
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IDA17121834
    GO:0005758mitochondrial intermembrane space IDA17121834
    GO:0005856cytoskeleton TAS10713127

    Find genes that share ontologies with STOML2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STOML2
    Interactions:

        Search GeneGlobe Interaction Network for STOML2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STOML2 (Q9UJZ12, 3 ENSP000003488864) via UniProtKB, MINT, STRING, and/or I2D (see all 343)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG482, 3, ENSP000003448184MINT-6489539 I2D: score=1 STRING: ENSP00000344818
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    SLC25A5P051412, ENSP000003606714MINT-6489539 MINT-8079030 STRING: ENSP00000360671
    COPS5Q929053, ENSP000003505124I2D: score=1 STRING: ENSP00000350512
    FTSJ1Q9UET63, ENSP000003269484I2D: score=1 STRING: ENSP00000326948
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006851mitochondrial calcium ion transport IMP19944461
    GO:0006874cellular calcium ion homeostasis IMP19944461
    GO:0007005mitochondrion organization IMP--
    GO:0010876lipid localization ISS--
    GO:0010918positive regulation of mitochondrial membrane potential IMP17121834

    Find genes that share ontologies with STOML2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STOML2 (STML2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STOML2 gene (4 alternative transcripts): 
    NM_001287031.1  NM_001287032.1  NM_001287033.1  NM_013442.2  

    Unigene Cluster for STOML2:

    Stomatin (EPB72)-like 2
    Hs.3439  [show with all ESTs]
    Unigene Representative Sequence: AK130546
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356493(uc003zwi.3 uc011lou.2) ENST00000488050 ENST00000487490
    ENST00000452248
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate STOML2:
    hsa-miR-3671
    SwitchGear 3'UTR luciferase reporter plasmidSTOML2 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat STOML2

    Additional mRNA sequence: 

    AF161458.1 AF190167.1 AF282596.1 AK027405.1 AK130546.1 AK223102.1 AK225114.1 AK303883.1 
    AK307343.1 AK308552.1 BC002442.2 BC003025.1 BC010152.2 BC014990.1 

    19 DOTS entries:

    DT.97765825  DT.454008  DT.95077356  DT.40218119  DT.100035220  DT.100804503  DT.121171259  DT.100887154 
    DT.102826339  DT.97779135  DT.102826338  DT.97860660  DT.121171282  DT.121632800  DT.95077407  DT.100887164 
    DT.121171284  DT.121171315  DT.97860659 

    Selected AceView cDNA sequences (see all 726):

    BQ073064 BM750562 BU501851 BE273795 BQ956929 CB149016 BQ050799 CB961880 
    BE621299 BM423453 BM829437 BQ954446 CB145366 BM822368 BQ676444 BE252977 
    CR592181 BQ675921 CR594962 BP369077 BM468527 BP347997 BU528995 CB136596 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STOML2 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                      -     -           -     -     -                                                                           
    SP2:                                      -     -     -     -     -     -                                                                           
    SP3:                                      -     -           -                                                                                       
    SP4:                                            -           -     -     -                                                                           
    SP5:                                                                                                                                -               


    ECgene alternative splicing isoforms for STOML2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STOML2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGTATATG
    STOML2 Expression
    About this image

    STOML2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STOML2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.3439

    UniProtKB/Swiss-Prot: STML2_HUMAN, Q9UJZ1
    Tissue specificity: Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level)

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STOML2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STOML2 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stoml21 , 5 stomatin (Epb7.2)-like 21, 5 89.42(n)1
    94.62(a)1
      4 (22.99 cM)5
    665921  NM_023231.21  NP_075720.11 
     430276905 
    chicken
    (Gallus gallus)
    Aves STOML26
    stomatin (EPB72)-like 2
    78(a)
    1 ↔ 1
    Z(8451027-8456885)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    81(a)
    71(a)
    1 ↔ many
    1 ↔ many
    GL343804.1(125687-136727)
    GL343194.1(3244442-3245581)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.256232 Xenopus laevis transcribed sequence with moderate similarity more 78.34(n)    CB983953.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635052 similar to stomatin (Epb7.2)-like 2 76.26(n)   394006  BC055126.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG29701 , 3 CG29701 66(a)3
    63.2(n)1
    66.06(a)1
      60A133
    378071  NM_001274232.11  NP_001261161.11 
    worm
    (Caenorhabditis elegans)
    Secernentea stl-11 , 3 erythrocyte band 7 integral membrane
    protein like3
    stl-11
    59(a)3
    58.52(n)1
    60.95(a)1
      I(9494873-9496083)3
    1727771  NM_001264177.11  NP_001251106.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G541001 AT5G54100 57.96(n)
    55.67(a)
      835497  NM_124790.3  NP_200221.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01585001 Os08g0158500 56.69(n)
    54.74(a)
      4344707  NM_001067571.1  NP_001061036.1 


    ENSEMBL Gene Tree for STOML2 (if available)
    TreeFam Gene Tree for STOML2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STOML2 gene
    STOML32  STOM2  NPHS22  STOML12  

    Find genes that share paralogs with STOML2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STOML2 (see all 125)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs741747911,2
    C--35056856(-) TCAGG-/GTGCTCC 1 -- int12Minor allele frequency- GT:0.00NA CSA 6
    rs1138498351,2
    C,F--35068050(+) CACCTG/TCCTCA 1 -- int14Minor allele frequency- T:0.05CSA WA NA 242
    rs1156617161,2
    C,F--35068062(+) ACACAC/TAGCCC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1420811911,2
    --35068319(+) TTACAC/TGACTA 1 -- ut310--------
    rs1457492481,2
    --35068326(+) ACTAAA/GGTTCA 1 -- ut310--------
    rs1386831041,2
    C--35068371(+) AGCTAA/GAGCCA 1 -- ut310--------
    rs6643571,2
    C,F,H--35068402(+) CTTGTC/TCCCAG 1 -- ut3119Minor allele frequency- T:0.02NS NA WA CSA EA EU 2487
    rs1920279861,2
    C--35068439(+) AACTCA/GTCTTG 2 T M mis10--------
    rs734973411,2
    C--35068639(+) TGGCTG/AAACGG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1494294701,2
    --35068706(+) GTCTTG/TTAAGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for STOML2 (35099888 - 35103154 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STOML2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893044CNV Loss21882294
    nsv893043CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STOML2
    DNA2.0 Custom Variant and Variant Library Synthesis for STOML2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608292    OMIM disorders: --

    1 disease for STOML2:    
    About MalaCards
    acromesomelic dysplasia

    2 diseases from the University of Copenhagen DISEASES database for STOML2:
    Acromesomelic dysplasia     Laryngeal squamous cell carcinoma

    Find genes that share disorders with STOML2           About GenesLikeMe

    7 Novoseek inferred disease relationships for STOML2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endometrial carcinoma 42.6 13 17342323 (6), 16533792 (3)
    carcinoma squamous cell 40.6 13 15694024 (2), 16533792 (2), 19839737 (2), 17306333 (1) (see all 5)
    dysplasia 24.2 3 11435687 (1), 16533792 (1)
    metastasis 22.9 8 17709317 (4), 19839737 (3), 19597348 (1), 15694024 (1)
    shock 7.67 4 17085086 (1), 17506944 (1)
    tumors 0 2 17709317 (2), 19597348 (1), 16533792 (1)
    cancer 0 2 11435687 (1), 16533792 (1)

    Genetic Association Database (GAD): STOML2
    Human Genome Epidemiology (HuGE) Navigator: STOML2 (1 document)

    Export disorders for STOML2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STOML2 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with STOML2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human SLP-2, a novel homologue of stomatin (band 7.2b) present in erythrocytes and other tissues. (PubMed id 10713127)1, 2, 3, 9 Wang Y. and Morrow J.S. (J. Biol. Chem. 2000)
    2. Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2. (PubMed id 17121834)1, 2, 3, 9 Hajek P.... Attardi G. (J. Biol. Chem. 2007)
    3. A novel member of the stomatin/EPB72/mec-2 family, stomatin-like 2 (STOML2), is ubiquitously expressed and localizes to HSA chromosome 9p13.1. (PubMed id 11435687)1, 2, 9 Owczarek C.M....Hertzog P.J. (Cytogenet. Cell Genet. 2001)
    4. Mass spectrometrical verification of stomatin-like protein 2 (SLP-2) primary structure. (PubMed id 16671055)1, 2, 9 John J.P.... Lubec G. (Proteins 2006)
    5. Modulation of T cell activation by stomatin-like protein 2. (PubMed id 18641330)1, 2, 9 Kirchhof M.G....Madrenas J. (J. Immunol. 2008)
    6. Mitochondrial and plasma membrane pools of stomatin-like protein 2 coalesce at the immunological synapse during T cell activation. (PubMed id 22623988)1, 2 Christie D.A.... Madrenas J. (PLoS ONE 2012)
    7. Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function. (PubMed id 21746876)1, 2 Christie D.A.... Madrenas J. (Mol. Cell. Biol. 2011)
    8. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    9. SLP-2 negatively modulates mitochondrial sodium-calcium exchange. (PubMed id 19944461)1, 2 Da Cruz S....Demaurex N. (Cell Calcium 2010)
    10. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 30968 HGNC: 14559 AceView: STOML2 Ensembl:ENSG00000165283 euGenes: HUgn30968
    ECgene: STOML2 H-InvDB: STOML2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STOML2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STOML2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STOML2 gene:
    Search GeneIP for patents involving STOML2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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