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Aliases for STOML1 Gene

Aliases for STOML1 Gene

  • Stomatin Like 1 2 3 5
  • Stomatin-Related Protein 3 4
  • Stomatin (EBP72)-Like 1 2 3
  • Stomatin (EPB72)-Like 1 2 3
  • Protein Unc-24 Homolog 3 4
  • EPB72-Like Protein 1 3 4
  • EPB72-Like 1 2 3
  • SLP-1 3 4
  • STORP 3 4
  • Stomatin-Like Protein 1 3
  • Stomatin-Like 1 2
  • HUNC-24 3
  • UNC24 4
  • SLP1 4

External Ids for STOML1 Gene

Previous GeneCards Identifiers for STOML1 Gene

  • GC15M070296
  • GC15M067391
  • GC15M071851
  • GC15M071991
  • GC15M072062
  • GC15M074275
  • GC15M051107

Summaries for STOML1 Gene

GeneCards Summary for STOML1 Gene

STOML1 (Stomatin Like 1) is a Protein Coding gene. An important paralog of this gene is STOML3.

Gene Wiki entry for STOML1 Gene

Additional gene information for STOML1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STOML1 Gene

Genomics for STOML1 Gene

Regulatory Elements for STOML1 Gene

Enhancers for STOML1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H073964 1.7 FANTOM5 Ensembl ENCODE dbSUPER 24.9 +29.0 28970 2 HDGF PKNOX1 TBL1XR1 RB1 SIN3A KLF17 BATF ZNF2 RAD21 GLIS2 STOML1 PML EDC3 LOC101929333 TBC1D21 LOXL1 CLK3 C15orf59 LOXL1-AS1
GH15H073955 1.3 Ensembl ENCODE dbSUPER 21.2 +37.9 37886 2 TBP JUN ZMYM3 MAX ZFHX2 POLR2A RCOR1 FOSL2 FOS CHD2 STOML1 PML LOXL1 LOXL1-AS1
GH15H073950 1.5 Ensembl ENCODE dbSUPER 17.5 +42.8 42811 3 HDGF ARID4B ZNF2 ETS1 GLIS2 ZNF143 RUNX3 REST MIER2 KAT8 EDC3 LOXL1 STOML1 PML STRA6 LOXL1-AS1
GH15H073993 1.7 FANTOM5 ENCODE dbSUPER 12.3 -1.4 -1373 4 HDGF PKNOX1 ARID4B SIN3A GLI4 YY1 ETS1 TCF12 ZNF121 GLIS2 STOML1 LOXL1-AS1 PML GC15M074020
GH15H074038 1.2 Ensembl ENCODE dbSUPER 17.2 -45.7 -45695 3 TAL1 GLI4 ZIC2 FOSL1 TCF12 ZFHX2 GATA2 NCOR1 ZNF600 TRIM24 STOML1 PML SCAMP5 GC15M074020
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STOML1 on UCSC Golden Path with GeneCards custom track

Promoters for STOML1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000079173 -1278 3401 HDGF PKNOX1 ARID4B SIN3A GLI4 YY1 ETS1 TCF12 ZNF121 GLIS2

Transcription factor binding sites by QIAGEN in the STOML1 gene promoter:

Genomic Location for STOML1 Gene

Chromosome:
15
Start:
73,978,923 bp from pter
End:
73,994,622 bp from pter
Size:
15,700 bases
Orientation:
Minus strand

Genomic View for STOML1 Gene

Genes around STOML1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STOML1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STOML1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STOML1 Gene

Proteins for STOML1 Gene

  • Protein details for STOML1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBI4-STML1_HUMAN
    Recommended name:
    Stomatin-like protein 1
    Protein Accession:
    Q9UBI4
    Secondary Accessions:
    • B3KQN0
    • B4DUU5
    • B4DXM9
    • E7ESC0
    • H3BRP3
    • O95675
    • Q4PNR4
    • Q6FGL8
    • Q8WYI7
    • Q9UMB9
    • Q9UMC0
    • Q9Y6H9

    Protein attributes for STOML1 Gene

    Size:
    398 amino acids
    Molecular mass:
    42968 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD42031.1; Type=Frameshift; Positions=201, 210; Evidence={ECO:0000305}; Sequence=CAA76271.1; Type=Frameshift; Positions=230, 233, 263, 292, 300; Evidence={ECO:0000305};

    Alternative splice isoforms for STOML1 Gene

neXtProt entry for STOML1 Gene

Post-translational modifications for STOML1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STOML1 Gene

Domains & Families for STOML1 Gene

Gene Families for STOML1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for STOML1 Gene

Suggested Antigen Peptide Sequences for STOML1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBI4

UniProtKB/Swiss-Prot:

STML1_HUMAN :
  • Belongs to the band 7/mec-2 family.
Family:
  • Belongs to the band 7/mec-2 family.
genes like me logo Genes that share domains with STOML1: view

Function for STOML1 Gene

Phenotypes From GWAS Catalog for STOML1 Gene

Gene Ontology (GO) - Molecular Function for STOML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 23082202
genes like me logo Genes that share ontologies with STOML1: view
genes like me logo Genes that share phenotypes with STOML1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STOML1

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STOML1 Gene

Localization for STOML1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STOML1 Gene

Membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STOML1 gene
Compartment Confidence
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STOML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STOML1: view

Pathways & Interactions for STOML1 Gene

SuperPathways for STOML1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STOML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with STOML1: view

No data available for Pathways by source and SIGNOR curated interactions for STOML1 Gene

Drugs & Compounds for STOML1 Gene

No Compound Related Data Available

Transcripts for STOML1 Gene

Unigene Clusters for STOML1 Gene

Stomatin (EPB72)-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for STOML1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - -
SP10: - - -
SP11: - - - - - - - - - - -
SP12:
SP13: -

ExUns: 10c · 10d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for STOML1 Gene

GeneLoc Exon Structure for
STOML1
ECgene alternative splicing isoforms for
STOML1

Expression for STOML1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STOML1 Gene

Protein differential expression in normal tissues from HIPED for STOML1 Gene

This gene is overexpressed in Bone (64.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STOML1 Gene



Protein tissue co-expression partners for STOML1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STOML1 Gene:

STOML1

SOURCE GeneReport for Unigene cluster for STOML1 Gene:

Hs.194816

mRNA Expression by UniProt/SwissProt for STOML1 Gene:

Q9UBI4-STML1_HUMAN
Tissue specificity: Ubiquitously expressed at low levels. Expression is highest in brain.

Evidence on tissue expression from TISSUES for STOML1 Gene

  • Nervous system(4.9)
  • Thyroid gland(4.2)
  • Intestine(4.1)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with STOML1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STOML1 Gene

Orthologs for STOML1 Gene

This gene was present in the common ancestor of animals.

Orthologs for STOML1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STOML1 34 33
  • 99.25 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STOML1 33 34
  • 89.61 (n)
dog
(Canis familiaris)
Mammalia STOML1 33 34
  • 88.42 (n)
rat
(Rattus norvegicus)
Mammalia Stoml1 33
  • 86.53 (n)
mouse
(Mus musculus)
Mammalia Stoml1 33 16 34
  • 86.15 (n)
oppossum
(Monodelphis domestica)
Mammalia STOML1 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STOML1 34
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves STOML1 33 34
  • 72.07 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia stoml1 33
  • 54.63 (n)
zebrafish
(Danio rerio)
Actinopterygii stoml1 34 33
  • 59.59 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31358 34
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea unc-24 33 34
  • 40.59 (n)
Species where no ortholog for STOML1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STOML1 Gene

ENSEMBL:
Gene Tree for STOML1 (if available)
TreeFam:
Gene Tree for STOML1 (if available)

Paralogs for STOML1 Gene

Paralogs for STOML1 Gene

(2) SIMAP similar genes for STOML1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with STOML1: view

Variants for STOML1 Gene

Sequence variations from dbSNP and Humsavar for STOML1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000490083 -- 73,983,130(+) TGTCA(A/G)TCCCT downstream-variant-500B
rs1000500043 -- 73,995,711(+) GTTTT(A/T)TTTTG intron-variant, upstream-variant-2KB
rs1000604037 -- 73,988,113(+) GGCAG(C/G)AAAAA intron-variant
rs1000676246 -- 73,988,417(+) CTACG(A/C)CCACC intron-variant
rs1000841062 -- 73,983,407(+) CATGC(C/G)CAATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for STOML1 Gene

Variant ID Type Subtype PubMed ID
esv2760040 CNV gain+loss 17122850
nsv1121512 CNV deletion 24896259
nsv428308 CNV gain+loss 18775914
nsv833052 CNV gain+loss 17160897

Variation tolerance for STOML1 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 25.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STOML1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STOML1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STOML1 Gene

Disorders for STOML1 Gene

Relevant External Links for STOML1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STOML1

No disorders were found for STOML1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STOML1 Gene

Publications for STOML1 Gene

  1. Molecular cloning of hSLP-1, a novel human brain-specific member of the band 7/MEC-2 family similar to Caenorhabditis elegans UNC-24. (PMID: 9931417) Seidel G … Prohaska R (Gene 1998) 2 3 4 22 60
  2. A novel gene STORP (STOmatin-Related Protein) is localized 2 kb upstream of the promyelocytic gene on chromosome 15q22. (PMID: 10997330) Gilles F … Zelenetz AD (European journal of haematology 2000) 3 4 22 60
  3. Stomatin-like protein-1 interacts with stomatin and is targeted to late endosomes. (PMID: 19696025) Mairhofer M … Prohaska R (The Journal of biological chemistry 2009) 3 22 60
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for STOML1 Gene

Sources for STOML1 Gene

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