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Aliases for STOML1 Gene

Aliases for STOML1 Gene

  • Stomatin Like 1 2 3 5
  • Stomatin-Related Protein 3 4
  • Stomatin (EBP72)-Like 1 2 3
  • Stomatin (EPB72)-Like 1 2 3
  • Protein Unc-24 Homolog 3 4
  • EPB72-Like Protein 1 3 4
  • EPB72-Like 1 2 3
  • SLP-1 3 4
  • STORP 3 4
  • Stomatin-Like 1 2
  • HUNC-24 3
  • UNC24 4
  • SLP1 4

External Ids for STOML1 Gene

Previous GeneCards Identifiers for STOML1 Gene

  • GC15M070296
  • GC15M067391
  • GC15M071851
  • GC15M071991
  • GC15M072062
  • GC15M074275
  • GC15M051107

Summaries for STOML1 Gene

GeneCards Summary for STOML1 Gene

STOML1 (Stomatin Like 1) is a Protein Coding gene. An important paralog of this gene is STOML3.

Gene Wiki entry for STOML1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STOML1 Gene

Genomics for STOML1 Gene

Regulatory Elements for STOML1 Gene

Enhancers for STOML1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STOML1 on UCSC Golden Path with GeneCards custom track

Promoters for STOML1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STOML1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the STOML1 gene promoter:

Genomic Location for STOML1 Gene

Chromosome:
15
Start:
73,978,923 bp from pter
End:
73,994,622 bp from pter
Size:
15,700 bases
Orientation:
Minus strand

Genomic View for STOML1 Gene

Genes around STOML1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STOML1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STOML1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STOML1 Gene

Proteins for STOML1 Gene

  • Protein details for STOML1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBI4-STML1_HUMAN
    Recommended name:
    Stomatin-like protein 1
    Protein Accession:
    Q9UBI4
    Secondary Accessions:
    • B3KQN0
    • B4DUU5
    • B4DXM9
    • E7ESC0
    • H3BRP3
    • O95675
    • Q4PNR4
    • Q6FGL8
    • Q8WYI7
    • Q9UMB9
    • Q9UMC0
    • Q9Y6H9

    Protein attributes for STOML1 Gene

    Size:
    398 amino acids
    Molecular mass:
    42968 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD42031.1; Type=Frameshift; Positions=201, 210; Evidence={ECO:0000305}; Sequence=CAA76271.1; Type=Frameshift; Positions=230, 233, 263, 292, 300; Evidence={ECO:0000305};

    Alternative splice isoforms for STOML1 Gene

neXtProt entry for STOML1 Gene

Proteomics data for STOML1 Gene at MOPED

Post-translational modifications for STOML1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STOML1 Gene

Domains & Families for STOML1 Gene

Protein Domains for STOML1 Gene

Suggested Antigen Peptide Sequences for STOML1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBI4

UniProtKB/Swiss-Prot:

STML1_HUMAN :
  • Contains 1 SCP2 domain.
  • Belongs to the band 7/mec-2 family.
Domain:
  • Contains 1 SCP2 domain.
Family:
  • Belongs to the band 7/mec-2 family.
genes like me logo Genes that share domains with STOML1: view

No data available for Gene Families for STOML1 Gene

Function for STOML1 Gene

genes like me logo Genes that share phenotypes with STOML1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STOML1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STOML1 Gene

Localization for STOML1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STOML1 Gene

Membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STOML1 Gene COMPARTMENTS Subcellular localization image for STOML1 gene
Compartment Confidence
cytosol 3
plasma membrane 3
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STOML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STOML1: view

Pathways & Interactions for STOML1 Gene

SuperPathways for STOML1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STOML1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for STOML1 Gene

Drugs & Compounds for STOML1 Gene

No Compound Related Data Available

Transcripts for STOML1 Gene

Unigene Clusters for STOML1 Gene

Stomatin (EPB72)-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STOML1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - -
SP10: - - -
SP11: - - - - - - - - - - -
SP12:
SP13: -

ExUns: 10c · 10d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for STOML1 Gene

GeneLoc Exon Structure for
STOML1
ECgene alternative splicing isoforms for
STOML1

Expression for STOML1 Gene

mRNA expression in normal human tissues for STOML1 Gene

Protein differential expression in normal tissues from HIPED for STOML1 Gene

This gene is overexpressed in Bone (64.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STOML1 Gene



SOURCE GeneReport for Unigene cluster for STOML1 Gene Hs.194816

mRNA Expression by UniProt/SwissProt for STOML1 Gene

Q9UBI4-STML1_HUMAN
Tissue specificity: Ubiquitously expressed at low levels. Expression is highest in brain.
genes like me logo Genes that share expression patterns with STOML1: view

Protein tissue co-expression partners for STOML1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for STOML1 Gene

Orthologs for STOML1 Gene

This gene was present in the common ancestor of animals.

Orthologs for STOML1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STOML1 35
  • 89.61 (n)
  • 91.71 (a)
STOML1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STOML1 35
  • 88.42 (n)
  • 91.96 (a)
STOML1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stoml1 35
  • 86.15 (n)
  • 89.42 (a)
Stoml1 16
Stoml1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STOML1 35
  • 99.25 (n)
  • 99.5 (a)
STOML1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stoml1 35
  • 86.53 (n)
  • 90.4 (a)
oppossum
(Monodelphis domestica)
Mammalia STOML1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STOML1 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves STOML1 35
  • 72.07 (n)
  • 65.81 (a)
STOML1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stoml1 35
  • 54.63 (n)
  • 50 (a)
zebrafish
(Danio rerio)
Actinopterygii stoml1 35
  • 59.59 (n)
  • 53.39 (a)
stoml1 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31358 36
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea unc-24 35
  • 40.59 (n)
  • 28.93 (a)
unc-24 36
  • 22 (a)
OneToOne
Species with no ortholog for STOML1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STOML1 Gene

ENSEMBL:
Gene Tree for STOML1 (if available)
TreeFam:
Gene Tree for STOML1 (if available)

Paralogs for STOML1 Gene

Paralogs for STOML1 Gene

(2) SIMAP similar genes for STOML1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with STOML1: view

Variants for STOML1 Gene

Sequence variations from dbSNP and Humsavar for STOML1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2507 -- 73,983,335(+) AGGAC(A/G)GAGCT utr-variant-3-prime
rs4993000 -- 73,990,002(+) ATGCA(C/T)TACCA intron-variant
rs734854 -- 73,989,507(+) TTAAC(C/T)ACTGC intron-variant
rs1061082 -- 73,984,028(-) GCGGC(C/G)CCTGG reference, missense
rs7171694 -- 73,985,683(+) GTAAG(A/T)GCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STOML1 Gene

Variant ID Type Subtype PubMed ID
dgv756e1 CNV Complex 17122850
nsv428308 CNV Gain+Loss 18775914
nsv833052 CNV Gain+Loss 17160897

Variation tolerance for STOML1 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 25.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STOML1 Gene

Disorders for STOML1 Gene

Relevant External Links for STOML1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STOML1

No disorders were found for STOML1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STOML1 Gene

Publications for STOML1 Gene

  1. Molecular cloning of hSLP-1, a novel human brain-specific member of the band 7/MEC-2 family similar to Caenorhabditis elegans UNC-24. (PMID: 9931417) Seidel G. … Prohaska R. (Gene 1998) 2 3 4 23 67
  2. Stomatin-like protein-1 interacts with stomatin and is targeted to late endosomes. (PMID: 19696025) Mairhofer M. … Prohaska R. (J. Biol. Chem. 2009) 3 23
  3. A novel gene STORP (STOmatin-Related Protein) is localized 2 kb upstream of the promyelocytic gene on chromosome 15q22. (PMID: 10997330) Gilles F. … Zelenetz A.D. (Eur. J. Haematol. 2000) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Stomatin-domain proteins. (PMID: 21501885) Lapatsina L. … Lewin G.R. (Eur. J. Cell Biol. 2012) 3

Products for STOML1 Gene

Sources for STOML1 Gene

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