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Aliases for STMN4 Gene

Aliases for STMN4 Gene

  • Stathmin 4 2 3 5
  • Stathmin-Like Protein B3 3 4
  • Stathmin-Like 4 2 3
  • RB3 3 4
  • Stathmin-Like-Protein RB3 3

External Ids for STMN4 Gene

Previous GeneCards Identifiers for STMN4 Gene

  • GC08M026874
  • GC08M027599
  • GC08M027115
  • GC08M025639
  • GC08M027092

Summaries for STMN4 Gene

GeneCards Summary for STMN4 Gene

STMN4 (Stathmin 4) is a Protein Coding gene. GO annotations related to this gene include tubulin binding. An important paralog of this gene is STMN1.

UniProtKB/Swiss-Prot for STMN4 Gene

  • Exhibits microtubule-destabilizing activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STMN4 Gene

Genomics for STMN4 Gene

Regulatory Elements for STMN4 Gene

Enhancers for STMN4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STMN4 on UCSC Golden Path with GeneCards custom track

Genomic Location for STMN4 Gene

Chromosome:
8
Start:
27,235,323 bp from pter
End:
27,258,865 bp from pter
Size:
23,543 bases
Orientation:
Minus strand

Genomic View for STMN4 Gene

Genes around STMN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STMN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STMN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STMN4 Gene

Proteins for STMN4 Gene

  • Protein details for STMN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H169-STMN4_HUMAN
    Recommended name:
    Stathmin-4
    Protein Accession:
    Q9H169
    Secondary Accessions:
    • B7Z2Z7
    • B7Z4I9
    • D3DSS8
    • D3DSS9
    • G5EA16
    • Q2TAB9

    Protein attributes for STMN4 Gene

    Size:
    189 amino acids
    Molecular mass:
    22071 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STMN4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STMN4 Gene

Proteomics data for STMN4 Gene at MOPED

Post-translational modifications for STMN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STMN4 Gene

Domains & Families for STMN4 Gene

Gene Families for STMN4 Gene

Protein Domains for STMN4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STMN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H169

UniProtKB/Swiss-Prot:

STMN4_HUMAN :
  • Contains 1 SLD (stathmin-like) domain.
  • Belongs to the stathmin family.
Domain:
  • Contains 1 SLD (stathmin-like) domain.
Family:
  • Belongs to the stathmin family.
genes like me logo Genes that share domains with STMN4: view

Function for STMN4 Gene

Molecular function for STMN4 Gene

UniProtKB/Swiss-Prot Function:
Exhibits microtubule-destabilizing activity.
genes like me logo Genes that share phenotypes with STMN4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STMN4 Gene

Localization for STMN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STMN4 Gene

Golgi apparatus. Cell projection, growth cone. Cell projection, axon.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STMN4 Gene COMPARTMENTS Subcellular localization image for STMN4 gene
Compartment Confidence
golgi apparatus 4
cytosol 3
extracellular 3
cytoskeleton 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for STMN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with STMN4: view

Pathways & Interactions for STMN4 Gene

SuperPathways for STMN4 Gene

No Data Available

Interacting Proteins for STMN4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000342538%0d%0a9606.ENSP00000262839%0d%0a
Selected Interacting proteins: Q9H169-STMN4_HUMAN ENSP00000342538 for STMN4 Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for STMN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007019 microtubule depolymerization IBA --
genes like me logo Genes that share ontologies with STMN4: view

No data available for Pathways by source and SIGNOR curated interactions for STMN4 Gene

Drugs & Compounds for STMN4 Gene

(2) Drugs for STMN4 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lomustine Approved Pharma Target, antagonist Antineoplastic drug 78
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with STMN4: view

Transcripts for STMN4 Gene

Unigene Clusters for STMN4 Gene

Stathmin-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STMN4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - -
SP5: -
SP6: - -
SP7:

Relevant External Links for STMN4 Gene

GeneLoc Exon Structure for
STMN4
ECgene alternative splicing isoforms for
STMN4

Expression for STMN4 Gene

mRNA expression in normal human tissues for STMN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STMN4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.6), Brain - Substantia nigra (x5.2), Brain - Hippocampus (x4.8), Brain - Amygdala (x4.2), Brain - Cortex (x4.2), Brain - Frontal Cortex (BA9) (x4.2), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for STMN4 Gene

This gene is overexpressed in NK cells (33.4) and Plasma (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STMN4 Gene



SOURCE GeneReport for Unigene cluster for STMN4 Gene Hs.201058

genes like me logo Genes that share expression patterns with STMN4: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for STMN4 Gene

Orthologs for STMN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for STMN4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STMN4 35
  • 92.77 (n)
  • 100 (a)
STMN4 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STMN4 35
  • 92.75 (n)
  • 99.07 (a)
STMN4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stmn4 35
  • 88.36 (n)
  • 99.47 (a)
Stmn4 16
Stmn4 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STMN4 35
  • 99.65 (n)
  • 100 (a)
STMN4 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stmn4 35
  • 88.89 (n)
  • 97.69 (a)
oppossum
(Monodelphis domestica)
Mammalia STMN4 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STMN4 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves STMN4 35
  • 82.72 (n)
  • 96.3 (a)
STMN4 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stmn4 35
  • 77.6 (n)
  • 86.24 (a)
African clawed frog
(Xenopus laevis)
Amphibia stmn4-prov 35
zebrafish
(Danio rerio)
Actinopterygii stmn4 35
  • 73.94 (n)
  • 80.85 (a)
wufj44e06 35
stmn4 36
  • 81 (a)
OneToMany
stmn4l 36
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta stai 36
  • 17 (a)
OneToMany
Species with no ortholog for STMN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STMN4 Gene

ENSEMBL:
Gene Tree for STMN4 (if available)
TreeFam:
Gene Tree for STMN4 (if available)

Paralogs for STMN4 Gene

Paralogs for STMN4 Gene

(3) SIMAP similar genes for STMN4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STMN4: view

Variants for STMN4 Gene

Sequence variations from dbSNP and Humsavar for STMN4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2028907 -- 27,252,462(-) aaaaa(A/T)TTttt intron-variant
rs7830242 -- 27,243,384(+) TACAG(A/T)TTTGA intron-variant
rs7830662 -- 27,243,689(+) CCCTT(A/C)ACACA intron-variant
rs7831609 -- 27,247,867(+) GTGCA(A/G)AAGCA intron-variant
rs7838654 -- 27,257,701(+) GGGGG(A/G)CTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STMN4 Gene

Variant ID Type Subtype PubMed ID
nsv831274 CNV Gain 17160897
nsv6131 CNV Loss 18451855

Variation tolerance for STMN4 Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STMN4 Gene

HapMap Linkage Disequilibrium report
STMN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STMN4 Gene

Disorders for STMN4 Gene

Relevant External Links for STMN4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STMN4

No disorders were found for STMN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STMN4 Gene

Publications for STMN4 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Expression of stathmin family genes in human tissues: non-neural- restricted expression for SCLIP. (PMID: 12676564) Bieche I. … Curmi P.A. (Genomics 2003) 3 23
  3. The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. (PMID: 9788875) Gavet O. … Sobel A. (J. Cell. Sci. 1998) 3 23
  4. The binding of vinca domain agents to tubulin: structural and biochemical studies. (PMID: 20466145) Cormier A. … Gigant B. (Methods Cell Biol. 2010) 23
  5. Protein macroarray profiling of serum autoantibodies in pseudoexfoliation glaucoma. (PMID: 20107165) Dervan E.W. … Murphy D. (Invest. Ophthalmol. Vis. Sci. 2010) 23

Products for STMN4 Gene

Sources for STMN4 Gene

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