STMN4 Gene
protein-coding GIFtS : 50
GCID: GC08 M027092
stathmin-like 4
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Aliasesfor STMN4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Stathmin-Like 4 1 2 RB31 2 3 Stathmin-Like Protein B32 3 Stathmin-41 Stathmin-Like-Protein RB32
Export aliases for STMN4 gene to outside databases Previous GC identifers: GC08M026874 GC08M027599 GC08M027115 GC08M027149 GC08M025639
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Summariesfor STMN4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: STMN4_HUMAN, Q9H169 Function : Exhibits microtubule-destabilizing activity (By similarity)
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Genomic Viewsfor STMN4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000008.10 NC_018919.1 NT_167187.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the STMN4 gene promoter: NF-1 NF-1/L MAZR AML1a CUTL1 POU6F1 (c2) E4BP4 AREB6 SRY S8 Other transcription factors Search SABiosciences Chromatin IP Primers for STMN4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STMN4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 8p21.2 Ensembl cytogenetic band: 8p21.2 HGNC cytogenetic band: 8p21.2 STMN4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08M027092: view genomic region
(about GC identifiers )
Start:
27,092,840 bp from pter
End:
27,115,937 bp from pter
Size:
23,098 bases
Orientation:
minus strand
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Proteinsfor STMN4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: STMN4_HUMAN, Q9H169 (See
protein sequence )Recommended Name: Stathmin-4 Size : 189 amino acids; 22071 Da
Subcellular location : Golgi apparatus (By similarity). Cell projection, growth cone (By similarity). Cell projection,axon (By similarity)
Secondary accessions : D3DSS8 D3DSS9 Q2TAB9Alternative splicing : 2 isoforms : Q9H169-1 Q9H169-2 Explore the universe of human proteins at neXtProt for STMN4: NX_Q9H169 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9H169 STMN4 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_110422.2 ENSEMBL proteins: ENSP00000342538 ENSP00000428474 ENSP00000265770 ENSP00000428428 ENSP00000430699 ENSP00000430389 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
STMN4 for ontologies About GeneDecksing STMN4 Antibody Products: Assay Products for STMN4:
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Protein
Domains / Familiesfor STMN4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
STMN4 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9H169 ProtoNet protein and cluster: Q9H169
1 Blocks protein family : IPB000956 Stathmin UniProtKB/Swiss-Prot: STMN4_HUMAN, Q9H169 Similarity : Belongs to the stathmin familySimilarity : Contains 1 SLD (stathmin-like) domain
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Functionfor STMN4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: STMN4_HUMAN, Q9H169 Function : Exhibits microtubule-destabilizing activity (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for STMN4 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for STMN4 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: STMN4 (NM_030795 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STMN4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat STMN4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STMN4
1 GenomeRNAi human phenotype for STMN4 :
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Pathways & Interactionsfor STMN4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STMN4 STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)5 Interacting proteins for STMN4 (Q9H169 2 , 3 ENSP00000342538 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0031110 regulation of microtubule polymerization or depolymerization
IEA -- GO:0035556 intracellular signal transduction
-- --
STMN4 for ontologies About GeneDecksing
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Drugs & Compoundsfor STMN4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for STMN4 2 DrugBank Compounds for STMN4 About this table Search CenterWatch for drugs/clinical trials and news about STMN4
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Transcriptsfor STMN4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for STMN4 gene: NM_030795.2 Unigene Cluster for STMN4:
Stathmin-like 4 Hs.201058 [show with all ESTs ] Unigene Representative Sequence: AK295329 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000350889 (uc003xfj.3 uc011lai.2 uc003xfk.3 ) ENST00000519997 (uc011laj.2 )ENST00000265770 ENST00000523048 ENST00000519614 (uc011lak.2 uc010luo.3 )ENST00000522908 ENST00000522750 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for STMN4 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for STMN4 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: STMN4 (NM_030795 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STMN4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat STMN4
Additional cDNA sequence: AJ303455.1 AK225142.1 AK294023.1 AK295329.1 AK297415.1 AK309207.1 AL136568.1 BC011520.1 BC111001.1
5 DOTS entries : DT.453623 DT.86847235
DT.95070010 DT.100779700 DT.75196092 24/129 AceView cDNA sequences (see all 129 ):
BM544782 AJ303455 CR591479 AW161604 T08783 BQ892309 AW297089 BI753462 AL136568 AW341050 NM_030795 AA297794 BC011520 AI929334 AL539699 BE551697 AI815865 BI600288 AA488120 AI815858 BE220383 AA679846 AW163622 H29709 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for STMN4 (see all 7 ) About this scheme ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c SP1 :       -         -       -         SP2 :       -   -       -       -         SP3 :       -   -       -               SP4 :     -   -   -   -     -       -         SP5 :               -              
ECgene alternative splicing isoforms for STMN4
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Expression for STMN4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section STMN4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ACCAATGAAA
About this image STMN4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Brain Blood Brain Barrier Endothelial Cells Blood Brain Barrier, Endothelium Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See STMN4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for STMN4 SOURCE GeneReport for Unigene cluster: Hs.201058 SABiosciences Custom PCR Arrays for STMN4 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for STMN4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat STMN4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat STMN4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat STMN4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STMN4
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Orthologsfor STMN4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for STMN4 gene from 4/16 species (see all 16 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
STMN41
stathmin-like 4
82.62(n) 96.28(a)
 
422010 XM_420017.3 XP_420017.2
African clawed frog (Xenopus laevis)
Amphibia
stmn4-prov2
stathmin-like 4
78.19(n)
 
BC054158.1
zebrafish (Danio rerio)
Actinopterygii
wufj44e062
Danio rerio cDNA clone MGC73243 IMAGE4146605, complete more
78.16(n)
 
BC059583.1
fruit fly (Drosophila melanogaster)
Insecta
stai6
stathmin
15(a)
1 → many
2L(6100377-6124653)
ENSEMBL Gene Tree for STMN4 (if available)TreeFam Gene Tree for STMN4 (if available)
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Paralogsfor STMN4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for STMN4 gene STMN3 2 STMN2 2 STMN1 2 3 SIMAP similar genes for STMN4 using alignment to 5 protein entries: STMN4_HUMAN (see all proteins ):STMN1 STMN2 STMN3
STMN4 for paralogs About GeneDecksing
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Genomic Variantsfor STMN4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 8 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for STMN4 (27092840 - 27115937 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for STMN4: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing STMN4
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Disorders
/ Diseasesfor STMN4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
STMN4 for disorders About GeneDecksing 3 diseases for STMN4 : About MalaCards exfoliation syndrome glaucoma gigantism 1 disease from the University of Copenhagen DISEASES database for STMN4 :Exfoliation syndrome Export disorders for STMN4 gene to outside databases
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Publicationsfor STMN4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for STMN4 gene, integrated from 9 sources (see all 19 ): (articles sorted by number of sources associating them with STMN4) Utopia : connect your pdf to the dynamic world of online information
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 1 , 2 , 3 Wiemann S.... Poustka A. (2001) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. (PubMed id 9788875) 1 , 9 Gavet O....Sobel A. (1998) Expression of stathmin family genes in human tissues: non-neural- restricted expression for SCLIP. (PubMed id 12676564) 1 , 9 Bieche I.... Curmi P.A. (2003) Nitrosoureas inhibit the stathmin-mediated migration and invasion of malignant glioma cells. (PubMed id 18593927) 7 Liang X.J....Park J.K. (2008) Covalent modification of stathmin by CCNU determined by FTMS analysis of modified proteins and tryptic peptides. (PubMed id 18162179) 7 Wu W.W....Shen R.F. (2008) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 1 Stelzl U.... Wanker E.E. (2005) TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. (PubMed id 12858178) 1 Greka A....Clapham D.E. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000)
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External Searches for STMN4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing STMN4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing STMN4 gene
(According to HUGE )
About This Section --
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Specialized Databases showing STMN4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for STMN4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for STMN4 gene: Search GeneIP for patents involving STMN4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor STMN4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for STMN4 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for STMN4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for STMN4 OriGene Protein Over-expression Lysate for STMN4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for STMN4 OriGene 3'-UTR Clone for STMN4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for STMN4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for STMN4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for STMN4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for STMN4 OriGene Custom Protein Services for STMN4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STMN4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing STMN4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STMN4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat STMN4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat STMN4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat STMN4
Search Tocris compounds for STMN4
STMN4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STMN4
Search ThermoFisher Antibodies for STMN4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat STMN4
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Aliases for STMN4
Databases for STMN4
Disorders / Diseases for STMN4
Domains / Families for STMN4
Drugs / Compounds for STMN4
Expression for STMN4
Function for STMN4
Genomic Views for STMN4
Intellectual Property for STMN4
Orthologs for STMN4
Paralogs for STMN4
Pathways / Interactions for STMN4
Products for STMN4
Proteins for STMN4
Publications for STMN4
Search Box for STMN4
Summaries for STMN4
Transcripts for STMN4
Variants for STMN4
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