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Aliases for STMN4 Gene

Aliases for STMN4 Gene

  • Stathmin-Like 4 2 3
  • Stathmin-Like Protein B3 3 4
  • RB3 3 4
  • Stathmin-Like-Protein RB3 3
  • Stathmin-4 3

External Ids for STMN4 Gene

Previous GeneCards Identifiers for STMN4 Gene

  • GC08M026874
  • GC08M027599
  • GC08M027115
  • GC08M025639
  • GC08M027092

Summaries for STMN4 Gene

GeneCards Summary for STMN4 Gene

STMN4 (Stathmin-Like 4) is a Protein Coding gene. Diseases associated with STMN4 include exfoliation syndrome. An important paralog of this gene is STMN1.

UniProtKB/Swiss-Prot for STMN4 Gene

  • Exhibits microtubule-destabilizing activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STMN4 Gene

Genomics for STMN4 Gene

Regulatory Elements for STMN4 Gene

Genomic Location for STMN4 Gene

Start:
27,235,323 bp from pter
End:
27,258,865 bp from pter
Size:
23,543 bases
Orientation:
Minus strand

Genomic View for STMN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STMN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STMN4 Gene

Proteins for STMN4 Gene

  • Protein details for STMN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H169-STMN4_HUMAN
    Recommended name:
    Stathmin-4
    Protein Accession:
    Q9H169
    Secondary Accessions:
    • B7Z2Z7
    • B7Z4I9
    • D3DSS8
    • D3DSS9
    • G5EA16
    • Q2TAB9

    Protein attributes for STMN4 Gene

    Size:
    189 amino acids
    Molecular mass:
    22071 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STMN4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STMN4 Gene

Proteomics data for STMN4 Gene at MOPED

Post-translational modifications for STMN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STMN4 Gene

Domains for STMN4 Gene

Protein Domains for STMN4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STMN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H169

UniProtKB/Swiss-Prot:

STMN4_HUMAN :
  • Q9H169
Domain:
  • Contains 1 SLD (stathmin-like) domain.
Family:
  • Belongs to the stathmin family.
genes like me logo Genes that share domains with STMN4: view

No data available for Gene Families for STMN4 Gene

Function for STMN4 Gene

Molecular function for STMN4 Gene

UniProtKB/Swiss-Prot Function: Exhibits microtubule-destabilizing activity.

Gene Ontology (GO) - Molecular Function for STMN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015631 tubulin binding IBA --
genes like me logo Genes that share ontologies with STMN4: view

Phenotypes for STMN4 Gene

genes like me logo Genes that share phenotypes with STMN4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for STMN4 Gene

Localization for STMN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STMN4 Gene

Golgi apparatus. Cell projection, growth cone. Cell projection, axon.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STMN4 Gene COMPARTMENTS Subcellular localization image for STMN4 gene
Compartment Confidence
cytosol 3
extracellular 3
cytoskeleton 2
golgi apparatus 2
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for STMN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005794 Golgi apparatus IEA --
GO:0030424 axon IEA --
GO:0030426 growth cone IEA --
GO:0042995 cell projection --
genes like me logo Genes that share ontologies with STMN4: view

Pathways for STMN4 Gene

SuperPathways for STMN4 Gene

No Data Available

Interacting Proteins for STMN4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000342538%0d%0a9606.ENSP00000262839%0d%0a
Selected Interacting proteins: Q9H169-STMN4_HUMAN ENSP00000342538 for STMN4 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for STMN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007019 microtubule depolymerization IBA --
GO:0031110 regulation of microtubule polymerization or depolymerization IEA --
GO:0031175 neuron projection development IBA --
GO:0051493 regulation of cytoskeleton organization IBA --
genes like me logo Genes that share ontologies with STMN4: view

No data available for Pathways by source for STMN4 Gene

Compounds for STMN4 Gene

(2) Drugbank Compounds for STMN4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
target
Lomustine
  • CCNU
13010-47-4 target antagonist
genes like me logo Genes that share compounds with STMN4: view

Transcripts for STMN4 Gene

Unigene Clusters for STMN4 Gene

Stathmin-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STMN4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - -
SP5: -
SP6: - -
SP7:

Relevant External Links for STMN4 Gene

GeneLoc Exon Structure for
STMN4
ECgene alternative splicing isoforms for
STMN4

Expression for STMN4 Gene

mRNA expression in normal human tissues for STMN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STMN4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (9.6), Brain - Substantia nigra (5.2), Brain - Hippocampus (4.8), Brain - Amygdala (4.2), Brain - Cortex (4.2), Brain - Frontal Cortex (BA9) (4.2), and Brain - Hypothalamus (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for STMN4 Gene

SOURCE GeneReport for Unigene cluster for STMN4 Gene Hs.201058

genes like me logo Genes that share expressions with STMN4: view

No data available for mRNA Expression by UniProt/SwissProt for STMN4 Gene

Orthologs for STMN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for STMN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STMN4 35
  • 99.65 (n)
  • 100 (a)
STMN4 36
  • 75 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STMN4 35
  • 92.77 (n)
  • 100 (a)
STMN4 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STMN4 35
  • 92.75 (n)
  • 99.07 (a)
STMN4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stmn4 35
  • 88.36 (n)
  • 99.47 (a)
Stmn4 16
Stmn4 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STMN4 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STMN4 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stmn4 35
  • 88.89 (n)
  • 97.69 (a)
chicken
(Gallus gallus)
Aves STMN4 35
  • 82.72 (n)
  • 96.3 (a)
STMN4 36
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia stmn4-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia stmn4 35
  • 77.6 (n)
  • 86.24 (a)
zebrafish
(Danio rerio)
Actinopterygii stmn4 35
  • 73.94 (n)
  • 80.85 (a)
stmn4 36
  • 81 (a)
OneToMany
stmn4l 36
  • 76 (a)
OneToMany
wufj44e06 35
fruit fly
(Drosophila melanogaster)
Insecta stai 36
  • 17 (a)
OneToMany
Species with no ortholog for STMN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STMN4 Gene

ENSEMBL:
Gene Tree for STMN4 (if available)
TreeFam:
Gene Tree for STMN4 (if available)

Paralogs for STMN4 Gene

Paralogs for STMN4 Gene

Selected SIMAP similar genes for STMN4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STMN4: view

Variants for STMN4 Gene

Sequence variations from dbSNP and Humsavar for STMN4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs879403 -- 27,244,525(+) ACAGA(A/G)ATAGG intron-variant
rs1542185 -- 27,239,117(-) GTTGC(A/G)TAGGC intron-variant
rs1545362 -- 27,238,014(-) CTGGG(G/T)GCCTC intron-variant
rs1562330 -- 27,240,919(-) TGTGC(A/G)GTGGA intron-variant
rs1562331 -- 27,240,229(-) AGCCA(C/T)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STMN4 Gene

Variant ID Type Subtype PubMed ID
nsv831274 CNV Gain 17160897
nsv6131 CNV Loss 18451855

Relevant External Links for STMN4 Gene

HapMap Linkage Disequilibrium report
STMN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STMN4 Gene

Disorders for STMN4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for STMN4 Gene including...

Search for STMN4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for STMN4 Gene

genes like me logo Genes that share disorders with STMN4: view

No data available for UniProtKB/Swiss-Prot for STMN4 Gene

Publications for STMN4 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Expression of stathmin family genes in human tissues: non-neural- restricted expression for SCLIP. (PMID: 12676564) Bieche I. … Curmi P.A. (Genomics 2003) 3 23
  3. The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. (PMID: 9788875) Gavet O. … Sobel A. (J. Cell. Sci. 1998) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for STMN4 Gene

Sources for STMN4 Gene

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