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Aliases for STMN3 Gene

Aliases for STMN3 Gene

  • Stathmin 3 2 3 5
  • SCG10-Like Protein 3 4
  • Stathmin-Like 3 2 3
  • SCLIP 3 4
  • Stathmin-3 3

External Ids for STMN3 Gene

Previous GeneCards Identifiers for STMN3 Gene

  • GC20M062148
  • GC20M062950
  • GC20M062998
  • GC20M062999
  • GC20M061741
  • GC20M062271
  • GC20M059001

Summaries for STMN3 Gene

Entrez Gene Summary for STMN3 Gene

  • This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for STMN3 Gene

STMN3 (Stathmin 3) is a Protein Coding gene. GO annotations related to this gene include protein domain specific binding and tubulin binding. An important paralog of this gene is STMN2.

UniProtKB/Swiss-Prot for STMN3 Gene

  • Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.

Gene Wiki entry for STMN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STMN3 Gene

Genomics for STMN3 Gene

Regulatory Elements for STMN3 Gene

Enhancers for STMN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F063657 1.2 ENCODE 11 -0.8 -753 2.7 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 LINC00029 MIR647 RTEL1 LOC105372725 GMEB2 ENSG00000237371 MIR1914 LINC01056 PRPF6 SLC2A4RG
GH20F063680 1.3 Ensembl ENCODE 9.8 -35.4 -35410 24.9 HDGF PKNOX1 MLX ZFP64 SIN3A ZNF548 FOS PAF1 ZNF263 SP3 LIME1 RTEL1 MIR647 MIR1914 SLC2A4RG ENSG00000229299 ENSG00000237371 ARFRP1 C20orf181 ZBTB46-AS1
GH20F062971 1.3 Ensembl ENCODE 9.8 +683.9 683883 3.8 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A ZNF48 ZNF2 SLC30A9 GLIS2 STMN3 SLC17A9 GC20P062974
GH20F063651 1.1 ENCODE 11 +4.3 4335 3.4 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 MIR647 MIR1914 LIME1 STMN3 RTEL1 LOC105372726
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STMN3 on UCSC Golden Path with GeneCards custom track

Promoters for STMN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for STMN3 Gene

63,639,705 bp from pter
63,657,682 bp from pter
17,978 bases
Minus strand

Genomic View for STMN3 Gene

Genes around STMN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STMN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STMN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STMN3 Gene

Proteins for STMN3 Gene

  • Protein details for STMN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KSQ5
    • B7WP52
    • B7Z5G4
    • O75527
    • Q969Y4

    Protein attributes for STMN3 Gene

    180 amino acids
    Molecular mass:
    21017 Da
    Quaternary structure:
    • Interacts with STAT3.

    Alternative splice isoforms for STMN3 Gene


neXtProt entry for STMN3 Gene

Post-translational modifications for STMN3 Gene

  • N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STMN3 Gene

No data available for DME Specific Peptides for STMN3 Gene

Domains & Families for STMN3 Gene

Gene Families for STMN3 Gene

Protein Domains for STMN3 Gene

Suggested Antigen Peptide Sequences for STMN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SLD (stathmin-like) domain.
  • Belongs to the stathmin family.
  • Contains 1 SLD (stathmin-like) domain.
  • Belongs to the stathmin family.
genes like me logo Genes that share domains with STMN3: view

Function for STMN3 Gene

Molecular function for STMN3 Gene

UniProtKB/Swiss-Prot Function:
Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.

Gene Ontology (GO) - Molecular Function for STMN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015631 tubulin binding IBA --
GO:0019904 protein domain specific binding ISS --
genes like me logo Genes that share ontologies with STMN3: view

Phenotypes for STMN3 Gene

genes like me logo Genes that share phenotypes with STMN3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STMN3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STMN3 Gene

Localization for STMN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STMN3 Gene

Golgi apparatus. Cell projection, growth cone. Cell projection, axon.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STMN3 gene
Compartment Confidence
golgi apparatus 4
cytosol 3
extracellular 2
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for STMN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005794 Golgi apparatus IEA --
GO:0030424 axon IEA --
GO:0030426 growth cone IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with STMN3: view

Pathways & Interactions for STMN3 Gene

SuperPathways for STMN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STMN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007019 microtubule depolymerization IBA --
GO:0007399 nervous system development TAS 9603203
GO:0031110 regulation of microtubule polymerization or depolymerization IEA --
GO:0031122 cytoplasmic microtubule organization ISS --
GO:0031175 neuron projection development ISS,IBA --
genes like me logo Genes that share ontologies with STMN3: view

No data available for Pathways by source and SIGNOR curated interactions for STMN3 Gene

Transcripts for STMN3 Gene

Unigene Clusters for STMN3 Gene

Stathmin-like 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STMN3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for STMN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STMN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STMN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STMN3 Gene

This gene is overexpressed in Brain - Cortex (x4.9), Brain - Frontal Cortex (BA9) (x4.3), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for STMN3 Gene

This gene is overexpressed in Pancreas (44.2), Fetal Brain (12.9), and Frontal cortex (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STMN3 Gene

Protein tissue co-expression partners for STMN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STMN3 Gene:


SOURCE GeneReport for Unigene cluster for STMN3 Gene:


mRNA Expression by UniProt/SwissProt for STMN3 Gene:

Tissue specificity: Neuron specific.
genes like me logo Genes that share expression patterns with STMN3: view

Orthologs for STMN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for STMN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STMN3 34 35
  • 98.13 (n)
(Monodelphis domestica)
Mammalia STMN3 35
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia STMN3 35
  • 94 (a)
(Bos Taurus)
Mammalia STMN3 34 35
  • 93.89 (n)
(Canis familiaris)
Mammalia STMN3 34 35
  • 92.18 (n)
(Mus musculus)
Mammalia Stmn3 34 16 35
  • 89.07 (n)
(Rattus norvegicus)
Mammalia Stmn3 34
  • 89.07 (n)
(Gallus gallus)
Aves STMN3 34 35
  • 86.3 (n)
(Anolis carolinensis)
Reptilia STMN3 35
  • 85 (a)
African clawed frog
(Xenopus laevis)
Amphibia stmn3-prov 34
(Danio rerio)
Actinopterygii LOC798970 34
  • 70.74 (n)
stmn3 35
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta stai 35
  • 14 (a)
Species where no ortholog for STMN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STMN3 Gene

Gene Tree for STMN3 (if available)
Gene Tree for STMN3 (if available)

Paralogs for STMN3 Gene

Paralogs for STMN3 Gene

(3) SIMAP similar genes for STMN3 Gene using alignment to 2 proteins: Pseudogenes for STMN3 Gene

genes like me logo Genes that share paralogs with STMN3: view

Variants for STMN3 Gene

Sequence variations from dbSNP and Humsavar for STMN3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1059250 -- 63,640,027(-) CAGAG(C/T)CACAC nc-transcript-variant, utr-variant-3-prime
rs111476975 -- 63,651,875(+) CTCGC(C/T)CTCCC intron-variant, upstream-variant-2KB
rs111486665 -- 63,650,831(+) CGCCG(C/T)CCAGG intron-variant
rs111686675 -- 63,654,677(+) TCACC(A/G)GGCGG nc-transcript-variant, upstream-variant-2KB
rs111753668 -- 63,647,950(+) TGTGT(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STMN3 Gene

Variant ID Type Subtype PubMed ID
esv2758806 CNV gain+loss 17122850
esv3646323 CNV loss 21293372
nsv1073085 CNV deletion 25765185
nsv1118926 CNV deletion 24896259
nsv1160690 CNV deletion 26073780
nsv428381 CNV gain+loss 18775914
nsv470563 CNV loss 18288195
nsv953307 CNV deletion 24416366
nsv953308 CNV deletion 24416366
nsv9827 CNV loss 18304495

Variation tolerance for STMN3 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STMN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STMN3 Gene

Disorders for STMN3 Gene

Relevant External Links for STMN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STMN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STMN3 Gene

Publications for STMN3 Gene

  1. Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. (PMID: 10655513) Bai C. … Caskey C.T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 64
  2. SCLIP: a novel SCG10-like protein of the stathmin family expressed in the nervous system. (PMID: 9603203) Ozon S. … Sobel A. (J. Neurochem. 1998) 2 3 4 64
  3. SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells. (PMID: 19824884) Ng D.C. … Cao X. (Biochem. J. 2010) 3 22 64
  4. The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion. (PMID: 18549247) Mahapatra N.R. … O'Connor D.T. (Biochemistry 2008) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for STMN3 Gene

Sources for STMN3 Gene

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