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STMN3 Gene

protein-coding   GIFtS: 51
GCID: GC20M062271

Stathmin-Like 3

  Search for STMN3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Stathmin-Like 31 2
SCLIP2 3 5
SCG10-Like Protein2 3
SCG10-like-protein2
stathmin-32

External Ids:    HGNC: 159261   Entrez Gene: 508612   Ensembl: ENSG000001974577   OMIM: 6083625   UniProtKB: Q9NZ723   
ORGUL members:         

Export aliases for STMN3 gene to outside databases

Previous GC identifers: GC20M062148 GC20M062950 GC20M062998 GC20M062999 GC20M061741 GC20M059001


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STMN3 Gene:
This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form
a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered
assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and
function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jan 2013)

GeneCards Summary for STMN3 Gene:
STMN3 (stathmin-like 3) is a protein-coding gene. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is STMN2.

UniProtKB/Swiss-Prot: STMN3_HUMAN, Q9NZ72
Function: Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity)

Gene Wiki entry for STMN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the STMN3 gene promoter:
         AP-1   ATF-2   NRSF form 1   NRSF form 2   ARP-1   c-Jun   NF-kappaB1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTMN3 promoter sequence
   Search Chromatin IP Primers for STMN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STMN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.3   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.3

STMN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STMN3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M062271:  view genomic region     (about GC identifiers)

Start:
62,271,061 bp from pter      End:
62,284,780 bp from pter
Size:
13,720 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STMN3_HUMAN, Q9NZ72 (See protein sequence)
Recommended Name: Stathmin-3  
Size: 180 amino acids; 21017 Da
Subunit: Interacts with STAT3 (By similarity)
Secondary accessions: B3KSQ5 B7WP52 O75527 Q969Y4

Explore the universe of human proteins at neXtProt for STMN3: NX_Q9NZ72

Explore proteomics data for STMN3 at MOPED

Post-translational modifications: 

  • N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent
    vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases
    ZDHHC3, ZDHHC7 and ZDHHC151
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STMN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001263239.1  NP_056978.2  

    ENSEMBL proteins: 
     ENSP00000359070   ENSP00000439840  

    STMN3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for STMN3
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    Novus Biologicals STMN3 Proteins
    Novus Biologicals STMN3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for STMN3
    Cloud-Clone Corp. Proteins for STMN3

     
    Search eBioscience for Proteins for STMN3 

    STMN3 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for STMN3

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    Cloud-Clone Corp. ELISAs for STMN3
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    Search eBioscience for ELISAs for STMN3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR028835 Stathmin-3
     IPR000956 Stathmin_fam

    Graphical View of Domain Structure for InterPro Entry Q9NZ72

    ProtoNet protein and cluster: Q9NZ72

    1 Blocks protein domain: IPB000956 Stathmin

    UniProtKB/Swiss-Prot: STMN3_HUMAN, Q9NZ72
    Similarity: Belongs to the stathmin family
    Similarity: Contains 1 SLD (stathmin-like) domain


    Find genes that share domains with STMN3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STMN3_HUMAN, Q9NZ72
    Function: Exhibits microtubule-destabilizing activity, which is antagonized by STAT3 (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019904protein domain specific binding ISS--
         
    Find genes that share ontologies with STMN3           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Stmn3 (no phenotypes)

    Find genes that share phenotypes with STMN3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STMN3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STMN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STMN3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STMN3

    miRNA
    Products:
        
    miRTarBase miRNAs that target STMN3:
    hsa-mir-106b-3p (MIRT038576), hsa-mir-197-3p (MIRT048052), hsa-mir-92a-3p (MIRT049539), hsa-mir-1260b (MIRT052675)

    Block miRNA regulation of human, mouse, rat STMN3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STMN3 (see all 12):
    hsa-miR-125a-5p hsa-miR-330-5p hsa-miR-4305 hsa-miR-3126-5p hsa-miR-637 hsa-miR-320e hsa-miR-125b hsa-miR-1255a
    SwitchGear 3'UTR luciferase reporter plasmidSTMN3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STMN3

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    GenScript: all cDNA clones in your preferred vector: STMN3 (NM_015894)
    Sino Biological Human cDNA Clone for STMN3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STMN3

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    Browse ESI BIO Cell Lines and PureStem Progenitors for STMN3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STMN3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STMN3_HUMAN, Q9NZ72: Golgi apparatus. Cell projection, growth cone. Cell projection, axon
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    extracellular2
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005794Golgi apparatus IEA--
    GO:0030424axon IEA--
    GO:0030426growth cone IEA--

    Find genes that share ontologies with STMN3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STMN3
    Interactions:

        GeneGlobe Interaction Network for STMN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for STMN3 (Q9NZ722, 3 ENSP000003590704) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPCS2Q150052, 3, ENSP000002636724MINT-64586 I2D: score=4 STRING: ENSP00000263672
    TRPC5Q9UL623, ENSP000002628394I2D: score=1 STRING: ENSP00000262839
    STAT3P407633I2D: score=1 
    CDKN1BENSP000002288724STRING: ENSP00000228872
    UBQLN1ENSP000003655764STRING: ENSP00000365576
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    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development TAS9603203
    GO:0031110regulation of microtubule polymerization or depolymerization IEA--
    GO:0031122cytoplasmic microtubule organization ISS--
    GO:0031175neuron projection development ISS--
    GO:0032314regulation of Rac GTPase activity ISS--

    Find genes that share ontologies with STMN3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STMN3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STMN3 gene (2 alternative transcripts): 
    NM_001276310.1  NM_015894.3  

    Unigene Cluster for STMN3:

    Stathmin-like 3
    Hs.639609  [show with all ESTs]
    Unigene Representative Sequence: AK094112
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370053(uc002yfr.1 uc021wgd.1) ENST00000540534
    miRNA
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    Block miRNA regulation of human, mouse, rat STMN3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STMN3 (see all 12):
    hsa-miR-125a-5p hsa-miR-330-5p hsa-miR-4305 hsa-miR-3126-5p hsa-miR-637 hsa-miR-320e hsa-miR-125b hsa-miR-1255a
    SwitchGear 3'UTR luciferase reporter plasmidSTMN3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STMN3
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    OriGene ORF clones in mouse, rat for STMN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STMN3 (NM_015894)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STMN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STMN3
    Primer
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    OriGene qPCR primer pairs and template standards for STMN3
    OriGene qSTAR qPCR primer pairs in human, mouse for STMN3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STMN3
      QuantiTect SYBR Green Assays in human, mouse, rat STMN3
      QuantiFast Probe-based Assays in human, mouse, rat STMN3

    Additional mRNA sequence: 

    AF069709.1 AK074860.1 AK094112.1 AK131326.1 AK298903.1 AK310010.1 BC009381.2 BC025234.1 
    BC032527.2 BC047671.1 BC056873.1 BC082248.1 NR_075070.1 

    Selected DOTS entries (see all 37):

    DT.95221068  DT.91923680  DT.120824905  DT.100881763  DT.120825003  DT.100881781  DT.216374  DT.95167293 
    DT.97778886  DT.100881764  DT.92442515  DT.120825149  DT.100654203  DT.100881755  DT.100881782  DT.120825167 
    DT.95167292  DT.100653716  DT.100881751  DT.100799518  DT.100841540  DT.100881748  DT.100830030  DT.120825092 

    Selected AceView cDNA sequences (see all 441):

    BI907319 BU174076 BU173238 BE382679 BM849490 BQ691840 AA937338 AA326588 
    AA938574 BQ674610 BQ686291 CR623033 BX355971 BQ890569 BM543191 BQ689216 
    BI820424 BQ687549 T33212 BQ687104 CR614160 BM846139 BQ639606 AA746245 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for STMN3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:              -                 -           -               
    SP2:              -                 -                           
    SP3:              -                                             
    SP4:                                                            


    ECgene alternative splicing isoforms for STMN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STMN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCAGCGC
    STMN3 Expression
    About this image


    STMN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 6 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Thymus (Hematopoietic System)
             Thymus
    STMN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STMN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.639609

    UniProtKB/Swiss-Prot: STMN3_HUMAN, Q9NZ72
    Tissue specificity: Neuron specific

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    QuantiFast Probe-based Assays in human, mouse, rat STMN3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STMN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STMN3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stmn31 , 5 stathmin-like 31, 5 89.07(n)1
    96.11(a)1
      2 (103.63 cM)5
    202621  NM_009133.31  NP_033159.11 
     1813064595 
    chicken
    (Gallus gallus)
    Aves STMN31 stathmin-like 3 86.3(n)
    93.89(a)
      419263  NM_001004393.1  NP_001004393.1 
    lizard
    (Anolis carolinensis)
    Reptilia STMN36
    stathmin-like 3
    85(a)
    1 ↔ 1
    GL343401.1(701644-791417)
    African clawed frog
    (Xenopus laevis)
    Amphibia stmn3-prov2 stathmin-like 3 75.95(n)    BC041517.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7989701 stathmin-3-like 70.74(n)
    66.67(a)
      798970  XM_001339340.5  XP_001339376.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta stai6
    stathmin
    14(a)
    1 → many
    2L(6100377-6124653)


    ENSEMBL Gene Tree for STMN3 (if available)
    TreeFam Gene Tree for STMN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STMN3 gene
    STMN22  STMN42  STMN12  
    3 SIMAP similar genes for STMN3 using alignment to 2 protein entries:     STMN3_HUMAN (see all proteins):
    STMN1    STMN2    STMN4

    Find genes that share paralogs with STMN3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for STMN3
    PGOHUM00000246294


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STMN3 (see all 392)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1160844511,2
    C,F--62244477(+) GCCACG/TTGGCA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs9093331,2
    C,F,A,H--62270637(+) CCCCAT/GGTCAG 3 -- ds50018Minor allele frequency- G:0.33NA EA 364
    rs1391976211,2
    --62270692(+) GTAGGC/TCCTGC 3 -- ds50010--------
    rs9145611,2
    C,F,A,H--62270905(+) ATCACC/TGTTGT 3 -- ds500133Minor allele frequency- T:0.16NS EA NA WA CSA 2919
    rs9093341,2
    C,F,O,H--62270930(+) ATAATC/AATGAT 3 -- ds500124Minor allele frequency- A:0.25MN EA NA NS WA 2742
    rs1874251451,2
    --62271104(+) TTGATA/TGAATT 3 -- ut31 nc-transcript-variant0--------
    rs115455101,2
    C--62271146(-) TAATAT/CGCACC 3 -- ut31 nc-transcript-variantese32Minor allele frequency- C:0.00NA 4
    rs1164441231,2
    C,F--62271187(+) ATGAGG/AAATAT 3 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.06WA 118
    rs10592501,2
    C,F,A,H--62271380(-) CAGAGC/TCACAC 3 -- ut31 nc-transcript-variantese314Minor allele frequency- T:0.13MN NA WA CSA EA 559
    rs1140152031,2
    C,F--62271396(+) CACTGG/ACAGTG 3 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for STMN3 (62271061 - 62284780 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STMN3 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4644n71CNV Loss21882294
    nsv470563CNV Loss18288195
    nsv913213CNV Loss21882294
    nsv913190CNV Loss21882294
    dgv4618n71CNV Loss21882294
    nsv913241CNV Loss21882294
    nsv913240CNV Loss21882294
    dgv4641n71CNV Loss21882294
    nsv9827CNV Loss18304495
    nsv428381CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608362    OMIM disorders: --


    Find genes that share disorders with STMN3           About GenesLikeMe


    Export disorders for STMN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STMN3 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with STMN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. (PubMed id 10655513)1, 2, 3 Bai C.... Caskey C.T. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    2. SCLIP: a novel SCG10-like protein of the stathmin family expressed in the nervous system. (PubMed id 9603203)1, 2, 3 Ozon S.... Sobel A. (J. Neurochem. 1998)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    6. SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells. (PubMed id 19824884)1, 9 Ng D.C....Cao X. (Biochem. J. 2010)
    7. The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion. (PubMed id 18549247)1, 9 Mahapatra N.R....O'Connor D.T. (Biochemistry 2008)
    8. Expression of stathmin family genes in human tissues: non-neural- restricted expression for SCLIP. (PubMed id 12676564)1, 9 Bieche I.... Curmi P.A. (Genomics 2003)
    9. Stathmin family proteins display specific molecular and tubulin binding properties. (PubMed id 11278715)1, 9 Charbaut E....Sobel A. (J. Biol. Chem. 2001)
    10. The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. (PubMed id 9788875)1, 9 Gavet O....Sobel A. (J. Cell. Sci. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50861 HGNC: 15926 AceView: STMN3 Ensembl:ENSG00000197457 euGenes: HUgn50861
    ECgene: STMN3 H-InvDB: STMN3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STMN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STMN3 gene:
    Search GeneIP for patents involving STMN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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