STMN3 Gene

Aliases
for STMN3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC20M062148 GC20M062950 GC20M062998 GC20M062999 GC20M061741 GC20M059001

Summaries
for STMN3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for STMN3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000020.10  NC_018931.2  NT_011362.11  

SwitchGear Promoter luciferase reporter plasmid: STMN3 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STMN3

STMN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M062271:  view genomic region     (about GC identifiers)

Proteins
for STMN3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for STMN3: NX_Q9NZ72

Explore proteomics data for STMN3 at MOPED

Post-translational modifications: 

STMN3 Human Recombinant Protein Products:

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	antibodies-online proteins for STMN3 (21 products)
	antibodies-online peptides for STMN3

STMN3 Antibody Products:

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	antibodies-online kits for STMN3 (10 products)

Domains /
Families
for STMN3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9NZ72

Find genes that share domains with STMN3           About GenesLikeMe

Function
for STMN3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for STMN3

miRNA Products:		miRTarBase miRNAs that target STMN3: hsa-mir-106b-3p (MIRT038576), hsa-mir-197-3p (MIRT048052), hsa-mir-92a-3p (MIRT049539), hsa-mir-1260b (MIRT052675)
		Block miRNA regulation of human, mouse, rat STMN3 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate STMN3 (see all 12):
		hsa-miR-125a-5p hsa-miR-330-5p hsa-miR-4305 hsa-miR-3126-5p hsa-miR-637 hsa-miR-320e hsa-miR-125b hsa-miR-1255a
		SwitchGear 3'UTR luciferase reporter plasmid: STMN3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for STMN3
		Predesigned siRNA for gene silencing in human, mouse, rat STMN3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for STMN3

Clone Products:		OriGene clones in human, mouse for STMN3 (see all 6) OriGene ORF clones in mouse, rat for STMN3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: STMN3 (NM_015894)
		Sino Biological Human cDNA Clone for STMN3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for STMN3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STMN3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for STMN3
		Browse ESI BIO Cell Lines and PureStem Progenitors for STMN3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STMN3

Localization
for STMN3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
golgi apparatus	5
cytosol	3
extracellular	2
nucleus	2
cytoskeleton	1

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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for STMN3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

Drugs & Compounds
for STMN3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for STMN3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for STMN3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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STMN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGGCAGCGC

About this image

Skeletal Muscle (Muscoskeletal System)    fully expand to see all 6 entries
Mononuclear Myocytes Hyoid Arch Muscles
Brain (Nervous System)    fully expand to see all 6 entries
Cerebral Cortex
Neural Tube (Nervous System)    fully expand to see all 3 entries
Metencephalon
Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
Human embryonic stem cells (family)
Thymus (Hematopoietic System)
Thymus

Primer Products:		OriGene qPCR primer pairs and template standards for STMN3 OriGene qSTAR qPCR primer pairs in human, mouse for STMN3
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STMN3
		QuantiTect SYBR Green Assays in human, mouse, rat STMN3
		QuantiFast Probe-based Assays in human, mouse, rat STMN3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STMN3

Orthologs
for STMN3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for STMN3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for STMN3 gene

STMN2²  STMN4²  STMN1²  

3 SIMAP similar genes for STMN3 using alignment to 2 protein entries:     STMN3_HUMAN (see all proteins):

STMN1    STMN2    STMN4

Find genes that share paralogs with STMN3           About GenesLikeMe


1 Pseudogenes.org Pseudogene for STMN3
PGOHUM00000246294

Genomic Variants
for STMN3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for STMN3 (see all 392)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1160844511,2	C,F	--	62244477(+)	GCCACG/TTGGCA	1	--	us2k1		1		WA	118
rs9093331,2	C,F,A,H	--	62270637(+)	CCCCAT/GGTCAG	3	--	ds5001		8		NA EA	364
rs1391976211,2		--	62270692(+)	GTAGGC/TCCTGC	3	--	ds5001		0	--	--	--	--
rs9145611,2	C,F,A,H	--	62270905(+)	ATCACC/TGTTGT	3	--	ds5001		33		NS EA NA WA CSA	2919
rs9093341,2	C,F,O,H	--	62270930(+)	ATAATC/AATGAT	3	--	ds5001		24		MN EA NA NS WA	2742
rs1874251451,2		--	62271104(+)	TTGATA/TGAATT	3	--	ut31 nc-transcript-variant		0	--	--	--	--
rs115455101,2	C	--	62271146(-)	TAATAT/CGCACC	3	--	ut31 nc-transcript-variantese3		2		NA	4
rs1164441231,2	C,F	--	62271187(+)	ATGAGG/AAATAT	3	--	ut31 nc-transcript-variant		1		WA	118
rs10592501,2	C,F,A,H	--	62271380(-)	CAGAGC/TCACAC	3	--	ut31 nc-transcript-variantese3		14		MN NA WA CSA EA	559
rs1140152031,2	C,F	--	62271396(+)	CACTGG/ACAGTG	3	--	ut31 nc-transcript-variant		1		WA	118

HapMap Linkage Disequilibrium report for STMN3 (62271061 - 62284780 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for STMN3 (see all 12):    About this table    

Variant ID	Type	Subtype	PubMed ID
dgv4644n71	CNV	Loss	21882294
nsv470563	CNV	Loss	18288195
nsv913213	CNV	Loss	21882294
nsv913190	CNV	Loss	21882294
dgv4618n71	CNV	Loss	21882294
nsv913241	CNV	Loss	21882294
nsv913240	CNV	Loss	21882294
dgv4641n71	CNV	Loss	21882294
nsv9827	CNV	Loss	18304495
nsv428381	CNV	Gain+Loss	18775914

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing STMN3

DNA2.0 Custom Variant and Variant Library Synthesis for STMN3

Disorders / Diseases
for STMN3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for STMN3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. (PubMed id 10655513)^{1, 2, 3} Bai C.... Caskey C.T. (Proc. Natl. Acad. Sci. U.S.A. 2000)
2. SCLIP: a novel SCG10-like protein of the stathmin family expressed in the nervous system. (PubMed id 9603203)^{1, 2, 3} Ozon S.... Sobel A. (J. Neurochem. 1998)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (Nature 2001)
6. SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells. (PubMed id 19824884)^{1, 9} Ng D.C....Cao X. (Biochem. J. 2010)
7. The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion. (PubMed id 18549247)^{1, 9} Mahapatra N.R....O'Connor D.T. (Biochemistry 2008)
8. Expression of stathmin family genes in human tissues: non-neural- restricted expression for SCLIP. (PubMed id 12676564)^{1, 9} Bieche I.... Curmi P.A. (Genomics 2003)
9. Stathmin family proteins display specific molecular and tubulin binding properties. (PubMed id 11278715)^{1, 9} Charbaut E....Sobel A. (J. Biol. Chem. 2001)
10. The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. (PubMed id 9788875)^{1, 9} Gavet O....Sobel A. (J. Cell. Sci. 1998)

External Searches for STMN3 gene

Genome Databases showing STMN3 gene

Other Databases showing STMN3 gene

Specialized Databases showing STMN3 gene

Products
for STMN3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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