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Aliases for STMN3 Gene

Aliases for STMN3 Gene

  • Stathmin 3 2 3 5
  • SCG10-Like Protein 3 4
  • Stathmin-Like 3 2 3
  • SCLIP 3 4
  • Stathmin-3 3

External Ids for STMN3 Gene

Previous GeneCards Identifiers for STMN3 Gene

  • GC20M062148
  • GC20M062950
  • GC20M062998
  • GC20M062999
  • GC20M061741
  • GC20M062271
  • GC20M059001

Summaries for STMN3 Gene

Entrez Gene Summary for STMN3 Gene

  • This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for STMN3 Gene

STMN3 (Stathmin 3) is a Protein Coding gene. GO annotations related to this gene include protein domain specific binding and tubulin binding. An important paralog of this gene is STMN2.

UniProtKB/Swiss-Prot for STMN3 Gene

  • Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.

Gene Wiki entry for STMN3 Gene

Additional gene information for STMN3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STMN3 Gene

Genomics for STMN3 Gene

Regulatory Elements for STMN3 Gene

Enhancers for STMN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H063657 1.2 ENCODE 23.8 -0.8 -753 2.7 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 ZNF610 GLIS1 DIDO1 GMEB2 LINC00029 MIR647 RTEL1 LOC105372725 STMN3 UCKL1 TCEA2 MRGBP
GH20H063953 1.4 ENCODE dbSUPER 14.7 -298.8 -298826 5.5 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 LINC00029 LOC105372725 ARFRP1 TNFRSF6B STMN3 LINC01056 UCKL1 TCEA2 HAR1A ENSG00000237371
GH20H063651 1.4 ENCODE dbSUPER 11 +4.3 4335 3.4 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF766 DIDO1 MRGBP GMEB2 MIR647 UCKL1 LIME1 STMN3 FNDC11 RTEL1 LOC105372726
GH20H063680 1.5 Ensembl ENCODE dbSUPER 9.8 -29.6 -29621 13.3 HDGF PKNOX1 ZFP64 SIN3A ZBTB7B GLIS2 ELK1 FOS ZNF548 DEK LIME1 RTEL1 DIDO1 MIR647 UCKL1 ENSG00000237371 ZGPAT SLC2A4RG ENSG00000229299 FNDC11
GH20H063638 1.5 Ensembl ENCODE dbSUPER 7.8 +16.9 16879 5 HDGF PKNOX1 ARID4B SIN3A DMAP1 TCF12 GLIS2 ELK1 ZNF143 ZNF207 ENSG00000237371 RTEL1 DIDO1 STMN3 HELZ2 TNFRSF6B GC20M063645 MHENCR
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STMN3 on UCSC Golden Path with GeneCards custom track

Promoters for STMN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139936 -918 1201 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 ZNF610 NBN

Genomic Locations for STMN3 Gene

Genomic Locations for STMN3 Gene
chr20:63,639,705-63,657,682
(GRCh38/hg38)
Size:
17,978 bases
Orientation:
Minus strand
chr20:62,271,061-62,284,780
(GRCh37/hg19)

Genomic View for STMN3 Gene

Genes around STMN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STMN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STMN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STMN3 Gene

Proteins for STMN3 Gene

  • Protein details for STMN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZ72-STMN3_HUMAN
    Recommended name:
    Stathmin-3
    Protein Accession:
    Q9NZ72
    Secondary Accessions:
    • B3KSQ5
    • B7WP52
    • B7Z5G4
    • O75527
    • Q969Y4

    Protein attributes for STMN3 Gene

    Size:
    180 amino acids
    Molecular mass:
    21017 Da
    Quaternary structure:
    • Interacts with STAT3.

    Alternative splice isoforms for STMN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STMN3 Gene

Post-translational modifications for STMN3 Gene

  • N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STMN3 Gene

No data available for DME Specific Peptides for STMN3 Gene

Domains & Families for STMN3 Gene

Gene Families for STMN3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STMN3 Gene

Suggested Antigen Peptide Sequences for STMN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZ72

UniProtKB/Swiss-Prot:

STMN3_HUMAN :
  • Belongs to the stathmin family.
Family:
  • Belongs to the stathmin family.
genes like me logo Genes that share domains with STMN3: view

Function for STMN3 Gene

Molecular function for STMN3 Gene

UniProtKB/Swiss-Prot Function:
Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.

Phenotypes From GWAS Catalog for STMN3 Gene

Gene Ontology (GO) - Molecular Function for STMN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015631 tubulin binding IBA --
GO:0019904 protein domain specific binding ISS --
genes like me logo Genes that share ontologies with STMN3: view

Phenotypes for STMN3 Gene

genes like me logo Genes that share phenotypes with STMN3: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STMN3 Gene

Localization for STMN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STMN3 Gene

Golgi apparatus. Cell projection, growth cone. Cell projection, axon.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STMN3 gene
Compartment Confidence
golgi apparatus 4
cytosol 3
extracellular 2
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for STMN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005794 Golgi apparatus IEA --
GO:0030424 axon IEA --
GO:0030426 growth cone IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with STMN3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for STMN3 Gene

Pathways & Interactions for STMN3 Gene

SuperPathways for STMN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STMN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007019 microtubule depolymerization IBA --
GO:0007399 nervous system development TAS 9603203
GO:0031110 regulation of microtubule polymerization or depolymerization IEA --
GO:0031122 cytoplasmic microtubule organization ISS --
GO:0031175 neuron projection development ISS --
genes like me logo Genes that share ontologies with STMN3: view

No data available for Pathways by source and SIGNOR curated interactions for STMN3 Gene

Drugs & Compounds for STMN3 Gene

No Compound Related Data Available

Transcripts for STMN3 Gene

Unigene Clusters for STMN3 Gene

Stathmin-like 3:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for STMN3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for STMN3 Gene

GeneLoc Exon Structure for
STMN3
ECgene alternative splicing isoforms for
STMN3

Expression for STMN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STMN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STMN3 Gene

This gene is overexpressed in Brain - Cortex (x4.9), Brain - Frontal Cortex (BA9) (x4.3), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for STMN3 Gene

This gene is overexpressed in Pancreas (44.2), Fetal Brain (12.9), and Frontal cortex (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STMN3 Gene



Protein tissue co-expression partners for STMN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STMN3 Gene:

STMN3

SOURCE GeneReport for Unigene cluster for STMN3 Gene:

Hs.639609

mRNA Expression by UniProt/SwissProt for STMN3 Gene:

Q9NZ72-STMN3_HUMAN
Tissue specificity: Neuron specific.

Evidence on tissue expression from TISSUES for STMN3 Gene

  • Nervous system(5)
  • Adrenal gland(4.4)
  • Pancreas(4)
  • Kidney(2.9)
genes like me logo Genes that share expression patterns with STMN3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STMN3 Gene

Orthologs for STMN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for STMN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STMN3 33 34
  • 98.13 (n)
oppossum
(Monodelphis domestica)
Mammalia STMN3 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STMN3 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STMN3 33 34
  • 93.89 (n)
dog
(Canis familiaris)
Mammalia STMN3 33 34
  • 92.18 (n)
mouse
(Mus musculus)
Mammalia Stmn3 33 16 34
  • 89.07 (n)
rat
(Rattus norvegicus)
Mammalia Stmn3 33
  • 89.07 (n)
chicken
(Gallus gallus)
Aves STMN3 33 34
  • 86.3 (n)
lizard
(Anolis carolinensis)
Reptilia STMN3 34
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia stmn3-prov 33
zebrafish
(Danio rerio)
Actinopterygii LOC798970 33
  • 70.74 (n)
stmn3 34
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta stai 34
  • 14 (a)
OneToMany
Species where no ortholog for STMN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STMN3 Gene

ENSEMBL:
Gene Tree for STMN3 (if available)
TreeFam:
Gene Tree for STMN3 (if available)

Paralogs for STMN3 Gene

Paralogs for STMN3 Gene

(3) SIMAP similar genes for STMN3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for STMN3 Gene

genes like me logo Genes that share paralogs with STMN3: view

Variants for STMN3 Gene

Sequence variations from dbSNP and Humsavar for STMN3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000121665 -- 63,639,726(+) CACAG(A/G)TGTTT nc-transcript-variant, utr-variant-3-prime
rs1000320928 -- 63,653,432(+) CGGGG(A/G)GGGGA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000440240 -- 63,651,561(+) GATTT(A/G)CCTTT intron-variant, upstream-variant-2KB
rs1000567247 -- 63,644,729(+) CCATG(A/T)GGATA intron-variant
rs1000619377 -- 63,649,803(+) GGGAT(C/T)ACAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STMN3 Gene

Variant ID Type Subtype PubMed ID
nsv9827 CNV loss 18304495
nsv953308 CNV deletion 24416366
nsv953307 CNV deletion 24416366
nsv470563 CNV loss 18288195
nsv428381 CNV gain+loss 18775914
nsv1160690 CNV deletion 26073780
nsv1118926 CNV deletion 24896259
nsv1073085 CNV deletion 25765185
esv3646323 CNV loss 21293372
esv2758806 CNV gain+loss 17122850

Variation tolerance for STMN3 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STMN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STMN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STMN3 Gene

Disorders for STMN3 Gene

Relevant External Links for STMN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STMN3

No disorders were found for STMN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STMN3 Gene

Publications for STMN3 Gene

  1. Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. (PMID: 10655513) Bai C … Caskey CT (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 4 60
  2. SCLIP: a novel SCG10-like protein of the stathmin family expressed in the nervous system. (PMID: 9603203) Ozon S … Sobel A (Journal of neurochemistry 1998) 2 3 4 60
  3. SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells. (PMID: 19824884) Ng DC … Cao X (The Biochemical journal 2009) 3 22 60
  4. The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion. (PMID: 18549247) Mahapatra NR … O'Connor DT (Biochemistry 2008) 3 22 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for STMN3 Gene

Sources for STMN3 Gene

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