Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STMN2 Gene

Aliases for STMN2 Gene

  • Stathmin 2 2 3 5
  • Superior Cervical Ganglion-10 Protein 3 4
  • Stathmin-Like 2 2 3
  • SCGN10 3 4
  • SCG10 3 4
  • Neuronal Growth-Associated Protein (Silencer Element) 3
  • Superior Cervical Ganglia, Neural Specific 10 3
  • Neuron-Specific Growth-Associated Protein 3
  • Protein SCG10 4

External Ids for STMN2 Gene

Previous HGNC Symbols for STMN2 Gene

  • SCGN10

Previous GeneCards Identifiers for STMN2 Gene

  • GC08P079409
  • GC08P080571
  • GC08P080246
  • GC08P080573
  • GC08P080685
  • GC08P076013

Summaries for STMN2 Gene

Entrez Gene Summary for STMN2 Gene

  • This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]

GeneCards Summary for STMN2 Gene

STMN2 (Stathmin 2) is a Protein Coding gene. Diseases associated with STMN2 include down syndrome and creutzfeldt-jakob disease. GO annotations related to this gene include calcium-dependent protein binding and tubulin binding. An important paralog of this gene is STMN1.

UniProtKB/Swiss-Prot for STMN2 Gene

  • Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).

Gene Wiki entry for STMN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STMN2 Gene

Genomics for STMN2 Gene

Regulatory Elements for STMN2 Gene

Genomic Location for STMN2 Gene

Chromosome:
8
Start:
79,610,814 bp from pter
End:
79,666,175 bp from pter
Size:
55,362 bases
Orientation:
Plus strand

Genomic View for STMN2 Gene

Genes around STMN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STMN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STMN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STMN2 Gene

Proteins for STMN2 Gene

  • Protein details for STMN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93045-STMN2_HUMAN
    Recommended name:
    Stathmin-2
    Protein Accession:
    Q93045
    Secondary Accessions:
    • A8K9M2
    • G3V110
    • O14952
    • Q6PK68

    Protein attributes for STMN2 Gene

    Size:
    179 amino acids
    Molecular mass:
    20828 Da
    Quaternary structure:
    • Interacts with MAPK8 (By similarity). Interacts with ITM2C. Interacts with KIF1BP. Interacts (via the N-terminal region) with CIB1 (via C-terminal region); the interaction is direct, occurs in a calcium-dependent manner and attenuates the neurite outgrowth inhibition of STMN2.

    Alternative splice isoforms for STMN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STMN2 Gene

Proteomics data for STMN2 Gene at MOPED

Post-translational modifications for STMN2 Gene

  • N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.
  • Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex.
  • Sumoylated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STMN2 Gene

Antibody Products

  • R&D Systems Antibodies for STMN2 (Stathmin-2/STMN2)

No data available for DME Specific Peptides for STMN2 Gene

Domains & Families for STMN2 Gene

Gene Families for STMN2 Gene

Protein Domains for STMN2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STMN2 Gene

Graphical View of Domain Structure for InterPro Entry

Q93045

UniProtKB/Swiss-Prot:

STMN2_HUMAN :
  • Contains 1 SLD (stathmin-like) domain.
  • Belongs to the stathmin family.
Domain:
  • Contains 1 SLD (stathmin-like) domain.
Family:
  • Belongs to the stathmin family.
genes like me logo Genes that share domains with STMN2: view

Function for STMN2 Gene

Molecular function for STMN2 Gene

UniProtKB/Swiss-Prot Function:
Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).
genes like me logo Genes that share phenotypes with STMN2: view

Animal Model Products

miRNA for STMN2 Gene

miRTarBase miRNAs that target STMN2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STMN2 Gene

Localization for STMN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STMN2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Golgi apparatus. Endosome. Cell projection, lamellipodium. Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STMN2 Gene COMPARTMENTS Subcellular localization image for STMN2 gene
Compartment Confidence
golgi apparatus 4
cytosol 3
endosome 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STMN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21215777
GO:0016020 membrane IEA --
GO:0030027 lamellipodium IDA 21215777
GO:0030424 axon IEA --
GO:0031982 vesicle IEA --
genes like me logo Genes that share ontologies with STMN2: view

Pathways & Interactions for STMN2 Gene

SuperPathways for STMN2 Gene

No Data Available

SIGNOR curated interactions for STMN2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for STMN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007026 negative regulation of microtubule depolymerization IDA 18452648
GO:0010977 negative regulation of neuron projection development IDA 18452648
GO:0031110 regulation of microtubule polymerization or depolymerization IEA --
GO:0031115 negative regulation of microtubule polymerization IDA 18452648
GO:1990090 cellular response to nerve growth factor stimulus IDA 21215777
genes like me logo Genes that share ontologies with STMN2: view

No data available for Pathways by source for STMN2 Gene

Drugs & Compounds for STMN2 Gene

(3) Drugs for STMN2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with STMN2: view

Transcripts for STMN2 Gene

Unigene Clusters for STMN2 Gene

Stathmin-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STMN2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - -
SP2: - - -
SP3: - -
SP4: - -
SP5:

Relevant External Links for STMN2 Gene

GeneLoc Exon Structure for
STMN2
ECgene alternative splicing isoforms for
STMN2

Expression for STMN2 Gene

mRNA expression in normal human tissues for STMN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STMN2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.5), Brain - Anterior cingulate cortex (BA24) (x6.5), Brain - Frontal Cortex (BA9) (x5.8), Brain - Hypothalamus (x5.7), Brain - Cortex (x5.3), and Brain - Cerebellum (x5.2).

Protein differential expression in normal tissues from HIPED for STMN2 Gene

This gene is overexpressed in Fetal Brain (7.5) and Fetal gut (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STMN2 Gene



SOURCE GeneReport for Unigene cluster for STMN2 Gene Hs.521651

mRNA Expression by UniProt/SwissProt for STMN2 Gene

Q93045-STMN2_HUMAN
Tissue specificity: Neuron specific.
genes like me logo Genes that share expression patterns with STMN2: view

Protein tissue co-expression partners for STMN2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for STMN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for STMN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STMN2 35
  • 99.81 (n)
  • 100 (a)
STMN2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STMN2 36
  • 92 (a)
OneToOne
STMN2 35
  • 94.97 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia STMN2 35
  • 97.58 (n)
  • 100 (a)
STMN2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stmn2 16
Stmn2 35
  • 92.74 (n)
  • 100 (a)
Stmn2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STMN2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STMN2 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stmn2 35
  • 93.3 (n)
  • 99.44 (a)
chicken
(Gallus gallus)
Aves STMN2 35
  • 88.83 (n)
  • 96.65 (a)
STMN2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STMN2 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stmn2 35
  • 80.52 (n)
  • 89.89 (a)
Str.9008 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8324 35
zebrafish
(Danio rerio)
Actinopterygii stmn2a 36
  • 70 (a)
OneToMany
stmn2b 36
  • 68 (a)
OneToMany
Dr.1841 35
stmn2a 35
  • 74.71 (n)
  • 78.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta stai 36
  • 14 (a)
OneToMany
Species with no ortholog for STMN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STMN2 Gene

ENSEMBL:
Gene Tree for STMN2 (if available)
TreeFam:
Gene Tree for STMN2 (if available)

Paralogs for STMN2 Gene

Paralogs for STMN2 Gene

(3) SIMAP similar genes for STMN2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for STMN2 Gene

genes like me logo Genes that share paralogs with STMN2: view

Variants for STMN2 Gene

Sequence variations from dbSNP and Humsavar for STMN2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs638553 -- 79,661,980(+) CCATA(G/T)ATGGA intron-variant
rs640452 -- 79,662,418(+) AAGGT(C/G)TATTA intron-variant
rs4930 -- 79,655,037(+) AGCTG(C/G)TATTA reference, missense
rs2120723 -- 79,662,079(-) ATATG(A/G)GGTCT intron-variant
rs2029820 -- 79,641,002(+) GATAA(C/T)TTCCA intron-variant

Variation tolerance for STMN2 Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STMN2 Gene

HapMap Linkage Disequilibrium report
STMN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for STMN2 Gene

Disorders for STMN2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for STMN2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
down syndrome
  • complete trisomy 21 syndrome
creutzfeldt-jakob disease
  • creutzfeldt-jakob disease, variant
alzheimer disease
  • alzheimer disease, late-onset
budd-chiari syndrome
  • membranous obstruction of the inferior vena cava
shprintzen-goldberg syndrome
  • goldberg-shprintzen syndrome
- elite association - COSMIC cancer census association via MalaCards
Search STMN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STMN2

Genetic Association Database (GAD)
STMN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STMN2
genes like me logo Genes that share disorders with STMN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STMN2 Gene

Publications for STMN2 Gene

  1. SCG10, a neuron-specific growth-associated protein in Alzheimer's disease. (PMID: 8622778) Okazaki T. … Mori N. (Neurobiol. Aging 1995) 2 3 4 23 67
  2. Regulation of neurite outgrowth by interactions between the scaffolding protein, JNK-associated leucine zipper protein, and neuronal growth-associated protein superior cervical ganglia clone 10. (PMID: 19959466) Xu H. … Reddy E.P. (J. Biol. Chem. 2010) 3 23
  3. Rnd1 regulates axon extension by enhancing the microtubule destabilizing activity of SCG10. (PMID: 18996843) Li Y.H. … PA1schel A.W. (J. Biol. Chem. 2009) 3 23
  4. Stathmin-like 2, a developmentally-associated neuronal marker, is expressed and modulated during osteogenesis of human mesenchymal stem cells. (PMID: 18611392) Chiellini C. … Amri E.Z. (Biochem. Biophys. Res. Commun. 2008) 3 23
  5. NRSF silencing induces neuronal differentiation of human mesenchymal stem cells. (PMID: 18570921) Yang Y. … Pei X. (Exp. Cell Res. 2008) 3 23

Products for STMN2 Gene

Sources for STMN2 Gene

Back to Top

Content