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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STMN2 Gene

protein-coding   GIFtS: 54
GCID: GC08P080573

stathmin-like 2


(Previous symbol: SCGN10)
 Explore 14 diseases affiliated with
STMN2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STMN2    

Aliases
for STMN2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Stathmin-Like 21 2     Neuronal Growth-Associated Protein (Silencer Element)2
SCG101 2 3 5     Stathmin-21
SCGN101 2 3 5     Superior Cervical Ganglia, Neural Specific 102
Superior Cervical Ganglion-10 Protein2 3     Protein SCG103
Neuron-Specific Growth-Associated Protein2     

External Ids:    HGNC: 105771   Entrez Gene: 110752   Ensembl: ENSG000001044357   OMIM: 6006215   UniProtKB: Q930453   

Export aliases for STMN2 gene to outside databases

Previous GC identifers: GC08P079409 GC08P080571 GC08P080246 GC08P080685 GC08P076013


Summaries
for STMN2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for STMN2:
This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule
dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought
to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome
and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of
this gene is located on the long arm of chromosome 6. (provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045
Function: Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently
controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from
multipolar stage and retards radial migration from the ventricular zone (By similarity)

Gene Wiki entry for STMN2


Genomic Views
for STMN2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STMN2 gene promoter:
         Pax-5   AP-1   ATF-2   NRSF form 1   NRSF form 2   Egr-4   USF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STMN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for STMN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STMN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.13   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.13

STMN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STMN2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P080573:  view genomic region     (about GC identifiers)

Start:
 80,523,049 bp from pter      End:
 80,578,397 bp from pter
Size:
 55,349 bases      Orientation:
 plus strand

Proteins
for STMN2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045 (See protein sequence)
Recommended Name: Stathmin-2  
Size: 179 amino acids; 20828 Da
Subunit: Interacts with MAPK8 (By similarity). Interacts with ITM2C
Subcellular location: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Cell projection, growth
cone. Membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cell projection, axon. Golgi apparatus.
Endosome (By similarity). Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth
cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms (By similarity)
Secondary accessions: A8K9M2 G3V110 O14952 Q6PK68
Alternative splicing: 2 isoforms:  Q93045-1   Q93045-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STMN2: NX_Q93045

Post-translational modifications:

  • Sumoylated1
  • Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex (By similarity)1
  • N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent
    • vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3,
    ZDHHC7 and ZDHHC151
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q93045

    • STMN2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186143.1  NP_008960.2  

    ENSEMBL proteins: 
     ENSP00000220876   ENSP00000429243   ENSP00000430102  

    Human Recombinant Protein Products: 
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    Novus Biologicals STMN2 Proteins
    Novus Biologicals STMN2 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for STMN2
    Uscn Proteins for STMN2

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005768endosome IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0016020membrane IEA--
    GO:0030424axon IEA--


    STMN2 for ontologies           About GeneDecksing



    STMN2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of STMN2
    R&D Systems Antibodies for STMN2 (Stathmin-2/STMN2)
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    ThermoFisher Antibody for STMN2

    Assay Products for STMN2: 
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    Uscn ELISAs and CLIAs for STMN2

    Protein Domains /
    Families
    for STMN2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STMN2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000956 Stathmin_fam
     IPR026729 Stathmin-2

    Graphical View of Domain Structure for InterPro Entry Q93045

    ProtoNet protein and cluster: Q93045

    1 Blocks protein family: IPB000956 Stathmin

    UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045
    Similarity: Belongs to the stathmin family
    Similarity: Contains 1 SLD (stathmin-like) domain


    Function
    for STMN2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045
    Function: Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently
    controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from
    multipolar stage and retards radial migration from the ventricular zone (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STMN2
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate STMN2 (see all 35):
    hsa-miR-513a-5p hsa-miR-29a hsa-miR-485-3p hsa-miR-374a hsa-miR-642b hsa-miR-222* hsa-miR-934 hsa-miR-27a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STMN2 (see all 7)
    OriGene shRNA RFP: STMN2
    OriGene siRNA: STMN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STMN2

    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STMN2 

    Cell Line
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    Search LifeMap BioReagents cell lines for STMN2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STMN2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514


    STMN2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for STMN2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STMN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/20 Interacting proteins for STMN2 (Q930451, 2, 3 ENSP000002208764) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TEX11Q8IYF31, 2, 3, ENSP000003409954EBI-714194,EBI-742397 MINT-67247 I2D: score=6 STRING: ENSP00000340995
    CCDC85AQ96PX62, 3, ENSP000003840404MINT-8272289 I2D: score=2 STRING: ENSP00000384040
    GPRASP2Q96D092, 3, ENSP000003390574MINT-8272311 I2D: score=2 STRING: ENSP00000339057
    NGFRP081382, 3, ENSP000001722294MINT-8272322 I2D: score=2 STRING: ENSP00000172229
    GPRASP1Q5JY772, 3MINT-65091 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007026negative regulation of microtubule depolymerization IDA18452648
    GO:0010976positive regulation of neuron projection development IDA18452648
    GO:0010977negative regulation of neuron projection development IDA18452648
    GO:0030182neuron differentiation NAS--
    GO:0031115negative regulation of microtubule polymerization IDA18452648


    STMN2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for STMN2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STMN2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STMN2
    3 Novoseek chemical compound relationships for STMN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 8.59 1 9056495 (1)
    serine 5.55 1 9056495 (1)
    tyrosine 0 2 16217794 (1), 10624949 (1)

    Search CenterWatch for drugs/clinical trials and news about STMN2 

    Transcripts
    for STMN2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STMN2 gene (2 alternative transcripts): 
    NM_001199214.1  NM_007029.3  

    Unigene Cluster for STMN2:

    Stathmin-like 2
    Hs.521651  [show with all ESTs]
    Unigene Representative Sequence: NM_001199214
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000220876(uc022awk.1 uc003ybj.3 uc010lzp.3) ENST00000518111
    ENST00000518491

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STMN2
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate STMN2 (see all 35):
    hsa-miR-513a-5p hsa-miR-29a hsa-miR-485-3p hsa-miR-374a hsa-miR-642b hsa-miR-222* hsa-miR-934 hsa-miR-27a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STMN2 (see all 7)
    OriGene shRNA RFP: STMN2
    OriGene siRNA: STMN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STMN2
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STMN2
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    GenScript: all cDNA clones in your preferred vector (see all 2): STMN2 (NM_007029)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STMN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STMN2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STMN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STMN2

    Additional cDNA sequence: 

    AK091336.1 AK292737.1 AK297485.1 AK297594.1 AK299500.1 AK308557.1 AK309130.1 AL110174.1 
    BC006302.2 BT020034.1 CR456833.1 D50375.1 

    23 DOTS entries:

    DT.100890447  DT.100890457  DT.100890446  DT.92449552  DT.100890467  DT.97846057  DT.100890442  DT.101976276 
    DT.100822578  DT.100822571  DT.95348432  DT.95362992  DT.100890468  DT.100890476  DT.100822586  DT.100832428 
    DT.121464794  DT.319886  DT.450469  DT.92449574  DT.95362986  DT.100801614  DT.95362987 

    24/695 AceView cDNA sequences (see all 695):

    AW162811 BX420978 BX420368 BX416501 BX461383 BX463744 BQ888184 BQ719883 
    AK091336 BX505321 T31492 BX419961 AL539686 CR591448 BX420820 CR618733 
    BX440620 AL539437 AL534209 AI631187 NM_007029 H11115 BX460853 AL534600 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for STMN2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
    SP1:                    -     -                                                         
    SP2:                    -     -                                   -                     
    SP3:                          -                                   -                     
    SP4:                    -     -                                                         
    SP5:                                                                                    


    ECgene alternative splicing isoforms for STMN2

    Expression
    for STMN2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STMN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTTAAAAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    STMN2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    HeartAtrioventricular NodeAtrioventricular Node CellsMyocardium
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    OvaryOvigerous CordOvarian Somatic CellsOvary
    BoneMaxillary ProcessBone
    EyeRetinaEye
    Gut TubeHindgutGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    N2/LSB induced-cells (Generation of midbra...)

    See STMN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STMN2

    SOURCE GeneReport for Unigene cluster: Hs.521651

    UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045
    Tissue specificity: Neuron specific

        SABiosciences Custom PCR Arrays for STMN2
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STMN2

    Orthologs
    for STMN2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for STMN2 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Stmn21 , 5 stathmin-like 21, 5 92.74(n)1
    100(a)1    		   3 (2.15 cM)5
    202571  NM_025285.21  NP_079561.11 
     85095275 
    chicken
    (Gallus gallus)    		 Aves STMN21 stathmin-like 2 88.83(n)
    96.65(a)    		   396095  NM_205181.1  NP_990512.1 
    lizard
    (Anolis carolinensis)    		 Reptilia STMN26
    		 --
    		 83(a)
    		 1 ↔ 1
    		 4(25179172-25187197)
    African clawed frog
    (Xenopus laevis)    		 Amphibia X71433.12   -- 81.22(n)    X71433.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.18412 Transcribed sequence with moderate similarity to protein more 76.15(n)    CF550104.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta stai6
    		 stathmin
    		 12(a)
    		 1 → many
    		 2L(6100377-6124653)


    ENSEMBL Gene Tree for STMN2 (if available)
    TreeFam Gene Tree for STMN2 (if available) 

    Paralogs
    for STMN2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STMN2 gene
    STMN32  STMN42  STMN12  
    3 SIMAP similar genes for STMN2 using alignment to 2 protein entries:     STMN2_HUMAN (see all proteins):
    STMN1    STMN3    STMN4

    STMN2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STMN2
    PGOHUM00000243835


    Genomic Variants
    for STMN2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/907 NCBI SNPs in STMN2 are shown (see all 907)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs134395901,2
    		H--80521133(+) TTATTT/AAAAAA 2 -- us2k14Minor allele frequency- A:0.00NS EA 384
    rs1926235081,2
    		--80521149(+) CATAAA/CTGAAG 2 -- us2k10--------
    rs1836711731,2
    		--80521160(+) TTAGGC/TGGCTA 2 -- us2k10--------
    rs1421180901,2
    		--80521180(+) AAATCA/GGAAAT 2 -- us2k10--------
    rs1884798761,2
    		--80521280(+) GCAGCC/TAACTG 2 -- us2k10--------
    rs1812838661,2
    		--80521307(+) TAATGC/GCATGA 2 -- us2k10--------
    rs1508900001,2
    		--80521358(+) GAGATA/GACACA 2 -- us2k10--------
    rs1858534831,2
    		--80521508(+) AAATGC/TCTATA 2 -- us2k10--------
    rs132511081,2
    		C,F,--80521516(+) ATATAT/GAGAGA 2 -- us2k19Minor allele frequency- G:0.07NA WA 430
    rs1903915011,2
    		--80521549(+) ACCCTG/TCCAAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for STMN2 (80523049 - 80578397 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for STMN2: --

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    Disorders / Diseases
    for STMN2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STMN2 for disorders           About GeneDecksing

    OMIM gene information: 600621    OMIM disorders: --

    14 diseases for STMN2:    About MalaCards
    variant creutzfeldt-jakob disease    down syndrome    neuronitis    alzheimer's disease
    cervicitis    velocardiofacial syndrome    dysautonomia    pheochromocytoma
    lung carcinoma    breast cancer    cerebritis    neuroblastoma
    carcinoma    hepatitis


    Export disorders for STMN2 gene to outside databases

    Publications
    for STMN2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STMN2 gene, integrated from 9 sources (see all 87):
    (articles sorted by number of sources associating them with STMN2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. SCG10, a neuron-specific growth-associated protein in Alzheimer's disease. (PubMed id 8622778)1, 2, 3, 9 Okazaki T.... Mori N. (1995)
    2. BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells. (PubMed id 18452648)1, 2 Gong Y....Yuan J. (2008)
    3. Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)1, 2 Gocke C.B.... Kang J. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6. (PubMed id 12140291)1, 3 Liu Z....Fisher R.A. (2002)
    7. Targeting of SCG10 to the area of the Golgi complex is mediated by its NH2-terminal region. (PubMed id 9030585)1, 9 Di Paolo G....Grenningloh G. (1997)
    8. The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion. (PubMed id 18549247)1, 9 Mahapatra N.R....O'Connor D.T. (2008)
    9. Stathmin family protein SCG10 differentially regulates the plus and minus end dynamics of microtubules at steady state in vitro: implications for its role in neurite outgrowth. (PubMed id 17311410)1, 9 Manna T....Wilson L. (2007)
    10. c-Jun N-terminal kinase-3 (JNK3)/stress-activated protein kinase-beta (SAPKbeta) binds and phosphorylates the neuronal microtubule regulator SCG10. (PubMed id 11718727)1, 9 Neidhart S....Arkinstall S. (2001)

    External Searches for STMN2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing STMN2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11075 HGNC: 10577 AceView: STMN2 Ensembl:ENSG00000104435 euGenes: HUgn11075
    ECgene: STMN2 H-InvDB: STMN2

    Other Databases showing STMN2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STMN2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STMN2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for STMN2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STMN2 gene:
    Search GeneIP for patents involving STMN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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