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Aliases & Descriptions for STMN2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| SCG10 1, 2, 3, 5 | | SCGN10 2, 3, 5 | | SGC10 2 |
| | | Descriptions |
|---|
| Protein SCG10 3 | | Superior cervical ganglion-10 protein 3 | | neuronal growth-associated protein (silencer element) 2 | | stathmin-like 2 2 | | superior cervical ganglia, neural specific 10 2 | | superiorcervical ganglia, neural specific 10 2 |
|
| | Search outside databases for aliases for STMN2 genePrevious GC identifers: GC08P079409 GC08P080571 GC08P080246 GC08P080573 |
Summaries for STMN2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for STMN2: Superior cervical ganglion-10 is a neuronal growth-associated protein that shares significant amino acid sequence similarity with the phosphoprotein stathmin (MIM 151442).[supplied by OMIM] UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045Function: May play a role in neuronal differentiation, and in modulating membrane interaction with the cytoskeleton during neurite outgrowthGene Wiki entry for STMN2 |
Genomic Location for STMN2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the STMN2 gene 
Entrez Gene cytogenetic band: 8q21.13 Ensembl cytogenetic band: 8q21.13 HGNC cytogenetic band: 8q21.13STMN2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P080685:
(about GC identifiers)
Start:
|
80,685,916 bp from pter |
End:
|
80,740,868 bp from pter |
Size:
|
54,953 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000008.9 NT_008183.18
| Proteins for STMN2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045 (See
protein sequence)Recommended Name: Stathmin-2 Size: 179 amino acids; 20828 Da
Subcellular location: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Cell projection, growth cone (By similarity). Membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cell projection, axon (By similarity). Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms (By similarity)
Secondary accessions: O14952 Q6PK68Post-translational modifications:
Sumoylated1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_008960.2
ENSEMBL proteins: ENSP00000220876
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: STMN2 
5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
): About this table
Antibodies for STMN2: Assays for STMN2: | Protein
Domains/ Families for STMN2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q93045
ProtoNet protein and cluster: Q93045 1 Blocks protein family: IPB000956 Stathmin
UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045Similarity: Belongs to the stathmin family | Gene Function for STMN2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007029
Applied Biosystems Silencer® siRNAs for STMN2
Sigma-Aldrich siRNA for STMN2  Sigma-Aldrich shRNA for STMN2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007029                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007029                                  untagged cDNA clones in CMV expression vector (see all 2): AK092187 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_007029
UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045Function: May play a role in neuronal differentiation, and in modulating membrane interaction with the cytoskeleton during neurite outgrowth1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for STMN2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for STMN2 
5/20 Interacting proteins for STMN2 (ENSP000002208763 Q930451, 2) via UniProtKB, MINT, and/or STRING (see all 20
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007242 | intracellular signaling cascade |
IEA | -- | | GO:0030182 | neuron differentiation |
NAS | -- | About this table
|
Drugs & Compounds for STMN2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for STMN2 2 Novoseek chemical compound relationships for STMN2 gene
About this table
|
Transcripts for STMN2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007029
Sigma-Aldrich siRNA for STMN2  Sigma-Aldrich shRNA for STMN2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_007029 REFSEQ mRNAs for STMN2 gene: NM_007029.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_007029               OriGene GFP tagged cDNA clone in CMV expression vector: NM_007029                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007029                                  untagged cDNA clones in CMV expression vector (see all 2): AK092187  Additional cDNA sequence: AK091336.1 AK292737.1 AK297485.1 AK297594.1 AK299500.1 AK308557.1 AK309130.1 AL110174.1 BC006302.2 BT020034.1 CR456833.1 CR591212.1 CR591448.1 CR593049.1 CR595801.1 CR597913.1 CR598266.1 CR599871.1 CR602351.1 CR605650.1 CR606122.1 CR607233.1 CR607906.1 CR608911.1 CR609420.1 CR609968.1 CR610743.1 CR611375.1 CR612959.1 CR614957.1 CR616668.1 CR618208.1 CR618531.1 CR618733.1 CR619618.1 CR621424.1 CR623788.1 D50375.1 23 DOTS entries: DT.100890447 DT.100890457 DT.100890446 DT.92449552 DT.100890467 DT.97846057 DT.100890442 DT.101976276 DT.100822578 DT.100822571 DT.95348432 DT.95362992 DT.100890468 DT.100890476 DT.100822586 DT.100832428 DT.121464794 DT.319886 DT.450469 DT.92449574 DT.95362986 DT.100801614 DT.95362987 24/695 AceView cDNA sequences (see all 695
):AL539437 BQ719696 BQ716309 BM668581 AW161301 AI797344 CR618531 AI631187 F05364 BQ069077 AI879957 BX416501 BX441248 AL534931 BM698094 D44809 AI954839 CR605650 BX419017 AW002911 CR611375 BU742863 AI096716 BX420359
highest scoring ESTs for STMN2:D45352 AA013234 AA053230 AA053833 AA054633 AA195605 AA252071 AA321949 AA326076 AA326541 Unigene Cluster for STMN2: Stathmin-like 2 Hs.521651 [show with all ESTs]Unigene Representative Sequence: AK091336
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for STMN2
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | |
| SP1: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for STMN2
1 Ensembl transcript including schematic representation: ENST00000220876
|
Expression for STMN2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| STMN2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for STMN2
1 / 2 / 3 5 probe-sets matching STMN2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTTTAAAAAG
SOURCE GeneReport for Unigene cluster: Hs.521651
Expression variation in blood from EXPOLDB for STMN2 UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045Tissue specificity: Neuron specific |
Orthologs for STMN2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for STMN2 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for STMN2
ENSEMBL Gene Tree for STMN2 | Paralogs for STMN2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for STMN2 gene
- STMN32 STMN42 STMN12
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for STMN2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for STMN2 (up to first 250kb)
|
Disorders & Mutations for STMN2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600621
|
Medical News for STMN2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for STMN2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/68 PubMed articles for STMN2 gene (see all 68
):- SCG10, a neuron-specific growth-associated protein in Alzheimer's disease. (PubMed id 8622778)1, 2, 3, 4 Okazaki T.... Mori N. (1995)
- Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)3, 4 Gocke C.B.... Kang J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6. (PubMed id 12140291)2, 3 Liu Z....Fisher R.A. (2002)
- Targeting of SCG10 to the area of the Golgi complex is mediated by its NH2-terminal region. (PubMed id 9030585)1, 3 Di Paolo G....Grenningloh G. (1997)
- The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion. (PubMed id 18549247)1, 3 Mahapatra N.R....O'Connor D.T. (2008)
- Stathmin family protein SCG10 differentially regulates the plus and minus end dynamics of microtubules at steady state in vitro: implications for its role in neurite outgrowth. (PubMed id 17311410)1, 3 Manna T....Wilson L. (2007)
- c-Jun N-terminal kinase-3 (JNK3)/stress-activated protein kinase-beta (SAPKbeta) binds and phosphorylates the neuronal microtubule regulator SCG10. (PubMed id 11718727)1, 3 Neidhart S....Arkinstall S. (2001)
- Rnd1 regulates axon extension by enhancing the microtubule destabilizing activity of SCG10. (PubMed id 18996843)1, 3 Li Y.H....PA1schel A.W. (2009)
- Stathmin-like 2, a developmentally-associated neuronal marker, is expressed and modulated during osteogenesis of human mesenchymal stem cells. (PubMed id 18611392)1, 3 Chiellini C....Amri E.Z. (2008)
|
Search for STMN2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing STMN2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing STMN2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STMN2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for STMN2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for STMN2:

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Incremental update: 13 Oct 2009
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