Aliases for STMN2 Gene
External Ids for STMN2 Gene
Previous HGNC Symbols for STMN2 Gene
Previous GeneCards Identifiers for STMN2 Gene
This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]
GeneCards Summary for STMN2 Gene
STMN2 (Stathmin 2) is a Protein Coding gene. Diseases associated with STMN2 include Down Syndrome and Creutzfeldt-Jakob Disease. GO annotations related to this gene include calcium-dependent protein binding and tubulin binding. An important paralog of this gene is STMN3.
UniProtKB/Swiss-Prot for STMN2 Gene
Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).