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STMN2 Gene

protein-coding   GIFtS: 60

GC08P080685
stathmin-like 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SCGN10)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
SCG10 1, 2, 3, 5
SCGN10 2, 3, 5
SGC10 2
Descriptions
Protein SCG10 3
Superior cervical ganglion-10 protein 3
neuronal growth-associated protein (silencer element) 2
stathmin-like 2 2
superior cervical ganglia, neural specific 10 2
superiorcervical ganglia, neural specific 10 2
External Ids
HGNC: 105771
Entrez Gene: 110752
UniProtKB: Q930453
Ensembl: ENSG000001044357
Search outside databases for aliases for STMN2 gene

Previous GC identifers: GC08P079409 GC08P080571 GC08P080246 GC08P080573

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for STMN2:
Superior cervical ganglion-10 is a neuronal growth-associated protein that shares significant amino
acid sequence similarity with the phosphoprotein stathmin (MIM 151442).[supplied by OMIM]

UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045
Function: May play a role in neuronal differentiation, and in modulating membrane interaction with
the cytoskeleton during neurite outgrowth

Gene Wiki entry for STMN2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the STMN2 gene  

Entrez Gene cytogenetic band: 8q21.13   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.13

STMN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P080685:     (about GC identifiers)

Start:
80,685,916 bp from pter
End:
80,740,868 bp from pter
Size:
54,953 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000008.9  NT_008183.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045 (See protein sequence)
Recommended Name: Stathmin-2  
Size: 179 amino acids; 20828 Da
Subcellular location: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity).
Cell projection, growth cone (By similarity). Membrane; Peripheral membrane protein; Cytoplasmic
side (Potential). Cell projection, axon (By similarity). Note=Associated with punctate structures
in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both
soluble and membrane-bound forms (By similarity)
Secondary accessions: O14952 Q6PK68

Post-translational modifications:

  • Sumoylated1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_008960.2  

    ENSEMBL proteins: 
    ENSP00000220876 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (STMN2)
    Human Recombinant Proteins from Abnova (STMN2)
                  OriGene Purified Recombinant Human Protein: STMN2 

    5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624 membrane fraction NAS--
    GO:0005625 soluble fraction NAS--
    GO:0005737 cytoplasm IEA--
    GO:0016020 membrane IEA--
    GO:0030426 growth cone IEA--
    About this table

    Antibodies for STMN2: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of STMN2
    Sigma-Aldrich Antibodies for STMN2
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (STMN2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (STMN2)
    Novus Biologicals Antibodies for STMN2

    Assays for STMN2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR000956 Stathmin
     IPR015444 Stathmin_2


       GeneDecks  STMN2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q93045

    ProtoNet protein and cluster: Q93045

    1 Blocks protein family: IPB000956 Stathmin

    UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045
    Similarity: Belongs to the stathmin family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (STMN2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (STMN2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007029

                  Applied Biosystems Silencer® siRNAs for STMN2

                  Sigma-Aldrich siRNA for STMN2  
                         Sigma-Aldrich shRNA for STMN2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_007029
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_007029
                                     untagged cDNA clones in CMV expression vector (see all 2): AK092187 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_007029

    UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045
    Function: May play a role in neuronal differentiation, and in modulating membrane interaction with
    the cytoskeleton during neurite outgrowth

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI16189514
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  STMN2 


    5/20 Interacting proteins for STMN2 (ENSP000002208763 Q930451, 2) via UniProtKB, MINT, and/or STRING (see all 20 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TEX11Q8IYF31EBI-714194, EBI-742397
    GPRASP1Q5JY772MINT-65091
    RGS20ENSP000002973133STRING (score=.973)
    RGS6ENSP000003476993STRING (score=.963)
    RESTENSP000003118163STRING (score=.937)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007242 intracellular signaling cascade IEA--
    GO:0030182 neuron differentiation NAS--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for STMN2
    2 Novoseek chemical compound relationships for STMN2 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 10.06 1 9056495 (1)
    tyrosine 0.00 2 16217794 (1), 10624949 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (STMN2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (STMN2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007029

                  Sigma-Aldrich siRNA for STMN2  
                         Sigma-Aldrich shRNA for STMN2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_007029  

    REFSEQ mRNAs for STMN2 gene: 

    NM_007029.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_007029  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_007029
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_007029
                                     untagged cDNA clones in CMV expression vector (see all 2): AK092187 

    Additional cDNA sequence: 

    AK091336.1 AK292737.1 AK297485.1 AK297594.1 AK299500.1 AK308557.1 AK309130.1 AL110174.1 
    BC006302.2 BT020034.1 CR456833.1 CR591212.1 CR591448.1 CR593049.1 CR595801.1 CR597913.1 
    CR598266.1 CR599871.1 CR602351.1 CR605650.1 CR606122.1 CR607233.1 CR607906.1 CR608911.1 
    CR609420.1 CR609968.1 CR610743.1 CR611375.1 CR612959.1 CR614957.1 CR616668.1 CR618208.1 
    CR618531.1 CR618733.1 CR619618.1 CR621424.1 CR623788.1 D50375.1 

    23 DOTS entries:

    DT.100890447  DT.100890457  DT.100890446  DT.92449552  DT.100890467  DT.97846057  DT.100890442  DT.101976276 
    DT.100822578  DT.100822571  DT.95348432  DT.95362992  DT.100890468  DT.100890476  DT.100822586  DT.100832428 
    DT.121464794  DT.319886  DT.450469  DT.92449574  DT.95362986  DT.100801614  DT.95362987 

    24/695 AceView cDNA sequences (see all 695 ):

    AL539437 BQ719696 BQ716309 BM668581 AW161301 AI797344 CR618531 AI631187 
    F05364 BQ069077 AI879957 BX416501 BX441248 AL534931 BM698094 D44809 
    AI954839 CR605650 BX419017 AW002911 CR611375 BU742863 AI096716 BX420359 

    highest scoring ESTs for STMN2:

    D45352 AA013234 AA053230 AA053833 AA054633 AA195605 AA252071 AA321949 AA326076 AA326541 

    Unigene Cluster for STMN2:

    Stathmin-like 2
    Hs.521651  [show with all ESTs]
    Unigene Representative Sequence: AK091336


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for STMN2

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
    SP1:                    -     -                                                         
    SP2:                    -     -                                   -                     
    SP3:                          -                                   -                     
    SP4:                    -     -                                                         
    SP5:                                                                                    

    About this scheme

    ECgene alternative splicing isoforms for STMN2

    1 Ensembl transcript including schematic representation:
    ENST00000220876  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    STMN2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for STMN2

    1 / 2 / 3

    5 probe-sets matching STMN2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    38800_at2, 3 U95-A 3 1.00 0.96 1.00 1.00 D45352 1.00 1.00 1.00 1

    203000_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

    203001_s_at2, 3 U133-A 2 1.00 0.95 -- -- NM_007029 0.60 1.00 0.82 1

    203000_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    203001_s_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
    GeneDecks  STMN2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTTTAAAAAG

    SOURCE GeneReport for Unigene cluster: Hs.521651

    Expression variation in blood from EXPOLDB for STMN2

    UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045
    Tissue specificity: Neuron specific

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for STMN2 gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    STMN21   -- stathmin-like 2 97.58(n)
    100(a)
    477918  XM_535108.2  XP_535108.2 
    chimpanzee
    (Pan troglodytes)
    STMN21   -- stathmin-like 2 99.07(n)
    98.88(a)
    464247  XM_001167123.1  XP_001167123.1 
    cow
    (Bos taurus)
    STMN21   -- stathmin-like 2 94.97(n)
    100(a)
    534991  NM_001034622.1  NP_001029794.1 
    rat
    (Rattus norvegicus)
    Stmn21   -- stathmin-like 2 93.3(n)
    99.44(a)
    84510  NM_053440.2  NP_445892.1 
    mouse
    (Mus musculus)
    Stmn21, 5 3 (6.60 cM)5
    stathmin-like 21, 5 92.74(n)1
    100(a)1
    202571  NM_025285.21  NP_079561.11 
     AI1597275  AI8398685  (see all 18)
    About this table        Species with no ortholog for STMN2

    ENSEMBL Gene Tree for STMN2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for STMN2 gene
    STMN32  STMN42  STMN12  

    Pseudogenes
    1 related pseudogene


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/296 NCBI SNPs in STMN2 are shown (see all 296 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 170)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs38124591,2
    A,C,F,H80684158(+) AAAGAC/TAGGAA 1 -- ng519Minor allele frequency- N:0.00EA NA EU WA 1922
    rs38124601,2
    A,C,F,H80685160(+) CAGGCA/GCCAGA 1 -- ng5112Minor allele frequency- G:0.22EA NA EU WA 1054
    rs49301,2
    C80729827(+) AGCTGC/GTATTA 1 A/G mis15Minor allele frequency- G:0.00MN EU EA WA 604
    --
    rs169195721,2
    F80685593(+) GCACAG/ACCCAG 1 -- ng512Minor allele frequency- A:0.00MN EA 356
    rs132657021,2
    H80740107(+) ACCTAG/AAAGGC 1 -- ng31 ese34Minor allele frequency- A:0.00EU EA WA 420
    rs132511081,2
    F80684071(+) ATATAT/GAGAGA 1 -- ng512Minor allele frequency- G:0.07NA 182
    rs20298191,2
    A,C,F,H,O80715635(+) TAACGA/TAGCTC 1 -- int111Minor allele frequency- T:0.31EU EA WA NA 974
    rs20298201,2
    A,C,F,H,O80715792(+) GATAAT/CTTCCA 1 -- int115Minor allele frequency- C:0.24EU EA WA NA 1336
    rs11597361,2
    A,C,F,H,O80713936(+) CTGCTA/GAAAGA 1 -- int111Minor allele frequency- G:0.24EU EA WA NA 918
    rs20298181,2
    A,C,F,H,O80715623(+) TTACAT/CTGGTT 1 -- int114Minor allele frequency- C:0.44NA PA EU EA WA 1234
    About this table

    HapMap Linkage Disequilibrium images for STMN2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 600621

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/68 PubMed articles for STMN2 gene (see all 68 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 11075 HGNC: 10577 AceView: STMN2 Ensembl:ENSG00000104435 euGenes: HUgn11075
    ECgene: STMN2 H-InvDB: STMN2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for STMN2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for STMN2-related products

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     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for STMN2 Antibodies for STMN2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for STMN2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for STMN2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for STMN2

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