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STMN2 Gene

protein-coding   GIFtS: 57
GCID: GC08P080573

Stathmin 2

(Previous name: stathmin-like 2)
(Previous symbol: SCGN10)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Stathmin 21 2     Neuron-Specific Growth-Associated Protein2
SCGN101 2 3 5     Neuronal Growth-Associated Protein (Silencer Element)2
SCG102 3 5     stathmin-22
Stathmin-Like 21 2     Superior Cervical Ganglia, Neural Specific 102
Superior Cervical Ganglion-10 Protein2 3     Protein SCG103

External Ids:    HGNC: 105771   Entrez Gene: 110752   Ensembl: ENSG000001044357   OMIM: 6006215   UniProtKB: Q930453   

Export aliases for STMN2 gene to outside databases

Previous GC identifers: GC08P079409 GC08P080571 GC08P080246 GC08P080685 GC08P076013


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STMN2 Gene:
This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule
dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also
thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with
Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this
gene. A pseudogene of this gene is located on the long arm of chromosome 6. (provided by RefSeq, Nov 2010)

GeneCards Summary for STMN2 Gene:
STMN2 (stathmin 2) is a protein-coding gene. Diseases associated with STMN2 include variant creutzfeldt-jakob disease, and cervicitis. An important paralog of this gene is STMN3.

UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045
Function: Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and
consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate
of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity)

Gene Wiki entry for STMN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STMN2 gene promoter:
         Pax-5   AP-1   ATF-2   NRSF form 1   NRSF form 2   Egr-4   USF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTMN2 promoter sequence
   Search Chromatin IP Primers for STMN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STMN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.13   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.13

STMN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STMN2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P080573:  view genomic region     (about GC identifiers)

Start:
80,523,049 bp from pter      End:
80,578,410 bp from pter
Size:
55,362 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045 (See protein sequence)
Recommended Name: Stathmin-2  
Size: 179 amino acids; 20828 Da
Subunit: Interacts with MAPK8 (By similarity). Interacts with ITM2C. Interacts with KIAA1279. Interacts (via the
N-terminus region) with CIB1 (via C-terminus region); the interaction is direct, occurs in a calcium-dependent
manner and attenuates the neurite outgrowth inhibition of STMN2
Secondary accessions: A8K9M2 G3V110 O14952 Q6PK68
Alternative splicing: 2 isoforms:  Q93045-1   Q93045-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STMN2: NX_Q93045

Explore proteomics data for STMN2 at MOPED

Post-translational modifications: 

  • Sumoylated1
  • Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex (By similarity)1
  • N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent
    vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases
    ZDHHC3, ZDHHC7 and ZDHHC151
  • Ubiquitination2 at Lys86, Lys119, Lys129
  • Modification sites at PhosphoSitePlus

  • See STMN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186143.1  NP_008960.2  

    ENSEMBL proteins: 
     ENSP00000220876   ENSP00000429243   ENSP00000430102  

    STMN2 Human Recombinant Protein Products:

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    Novus Biologicals STMN2 Proteins
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    STMN2 Antibody Products:

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    STMN2 Assay Products:

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    Cloud-Clone Corp. CLIAs for STMN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000956 Stathmin_fam
     IPR026729 Stathmin-2

    Graphical View of Domain Structure for InterPro Entry Q93045

    ProtoNet protein and cluster: Q93045

    1 Blocks protein domain: IPB000956 Stathmin

    UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045
    Similarity: Belongs to the stathmin family
    Similarity: Contains 1 SLD (stathmin-like) domain


    STMN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STMN2_HUMAN, Q93045
    Function: Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and
    consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate
    of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0048306calcium-dependent protein binding IPI--
         
    STMN2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STMN2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STMN2
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    Selected qRT-PCR Assays for microRNAs that regulate STMN2 (see all 35):
    hsa-miR-513a-5p hsa-miR-29a hsa-miR-485-3p hsa-miR-374a hsa-miR-642b hsa-miR-222* hsa-miR-934 hsa-miR-27a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Sino Biological Human cDNA Clone for STMN2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STMN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STMN2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STMN2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STMN2_HUMAN, Q93045: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Cell projection,
    growth cone. Membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cell projection, axon. Golgi
    apparatus. Endosome (By similarity). Cell projection, lamellipodium. Note=Associated with punctate structures in
    the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and
    membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By
    similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1
    to the leading edge of lamellipodia
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    cytoskeleton2
    endosome2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005768endosome IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0016020membrane IEA--
    GO:0030027lamellipodium IDA--

    STMN2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STMN2
    Interactions:

        GeneGlobe Interaction Network for STMN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for STMN2 (Q930451, 2, 3 ENSP000002208764) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TEX11Q8IYF31, 2, 3, ENSP000003409954EBI-714194,EBI-742397 MINT-67247 I2D: score=6 STRING: ENSP00000340995
    GPRASP1Q5JY772, 3, ENSP000003551464MINT-65091 I2D: score=4 STRING: ENSP00000355146
    CCDC85AQ96PX62, 3, ENSP000003840404MINT-8272289 I2D: score=2 STRING: ENSP00000384040
    GPRASP2Q96D092, 3, ENSP000003390574MINT-8272311 I2D: score=2 STRING: ENSP00000339057
    NGFRP081382, 3, ENSP000001722294MINT-8272322 I2D: score=2 STRING: ENSP00000172229
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007026negative regulation of microtubule depolymerization IDA18452648
    GO:0010976positive regulation of neuron projection development IDA18452648
    GO:0010977negative regulation of neuron projection development IDA18452648
    GO:0030182neuron differentiation ----
    GO:0031110regulation of microtubule polymerization or depolymerization ----

    STMN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STMN2

    3 Novoseek inferred chemical compound relationships for STMN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 8.59 1 9056495 (1)
    serine 5.55 1 9056495 (1)
    tyrosine 0 2 16217794 (1), 10624949 (1)



    STMN2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STMN2 gene (2 alternative transcripts): 
    NM_001199214.1  NM_007029.3  

    Unigene Cluster for STMN2:

    Stathmin-like 2
    Hs.521651  [show with all ESTs]
    Unigene Representative Sequence: NM_001199214
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000220876(uc022awk.1 uc003ybj.3 uc010lzp.3) ENST00000518111
    ENST00000518491

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate STMN2 (see all 35):
    hsa-miR-513a-5p hsa-miR-29a hsa-miR-485-3p hsa-miR-374a hsa-miR-642b hsa-miR-222* hsa-miR-934 hsa-miR-27a
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      QuantiTect SYBR Green Assays in human, mouse, rat STMN2
      QuantiFast Probe-based Assays in human, mouse, rat STMN2

    Additional mRNA sequence: 

    AK091336.1 AK292737.1 AK297485.1 AK297594.1 AK299500.1 AK308557.1 AK309130.1 AL110174.1 
    BC006302.2 BT020034.1 CR456833.1 D50375.1 

    23 DOTS entries:

    DT.100890447  DT.100890457  DT.100890446  DT.92449552  DT.100890467  DT.97846057  DT.100890442  DT.101976276 
    DT.100822578  DT.100822571  DT.95348432  DT.95362992  DT.100890468  DT.100890476  DT.100822586  DT.100832428 
    DT.121464794  DT.319886  DT.450469  DT.92449574  DT.95362986  DT.100801614  DT.95362987 

    Selected AceView cDNA sequences (see all 695):

    CR593049 CR609420 NM_007029 F07100 AL538816 BQ716309 BX461096 D44901 
    CR607233 T31472 AW160495 AI632319 F03021 BX441248 AL534929 AV718061 
    AI954839 BX423482 BX419884 BE674347 F10737 BE466702 BX419235 BX461946 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for STMN2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
    SP1:                    -     -                                                         
    SP2:                    -     -                                   -                     
    SP3:                          -                                   -                     
    SP4:                    -     -                                                         
    SP5:                                                                                    


    ECgene alternative splicing isoforms for STMN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STMN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTAAAAAG
    STMN2 Expression
    About this image


    STMN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Horizontal Cells Inner Nuclear Layer
             Retina
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Endocardial Tube Cells Endocardium
             Outflow Tract
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Maxillary Process
             HyStem+BMP4-induced SK11 cells
    STMN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STMN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.521651

    UniProtKB/Swiss-Prot: STMN2_HUMAN, Q93045
    Tissue specificity: Neuron specific

        Custom PCR Arrays for STMN2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STMN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STMN2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stmn21 , 5 stathmin-like 21, 5 92.74(n)1
    100(a)1
      3 (2.15 cM)5
    202571  NM_025285.21  NP_079561.11 
     85095275 
    chicken
    (Gallus gallus)
    Aves STMN21 stathmin-like 2 88.83(n)
    96.65(a)
      396095  NM_205181.1  NP_990512.1 
    lizard
    (Anolis carolinensis)
    Reptilia STMN26
    stathmin-like 2
    88(a)
    1 ↔ 1
    4(25177655-25209259)
    African clawed frog
    (Xenopus laevis)
    Amphibia X71433.12   -- 81.22(n)    X71433.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.18412 Transcribed sequence with moderate similarity to protein more 76.15(n)    CF550104.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta stai6
    stathmin
    14(a)
    1 → many
    2L(6100377-6124653)


    ENSEMBL Gene Tree for STMN2 (if available)
    TreeFam Gene Tree for STMN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STMN2 gene
    STMN32  STMN42  STMN12  
    3 SIMAP similar genes for STMN2 using alignment to 2 protein entries:     STMN2_HUMAN (see all proteins):
    STMN1    STMN3    STMN4

    STMN2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STMN2
    PGOHUM00000243835


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STMN2 (see all 1063)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs134395901,2
    H--80521133(+) TTATTT/AAAAAA 2 -- us2k14Minor allele frequency- A:0.00NS EA 384
    rs1926235081,2
    --80521149(+) CATAAA/CTGAAG 2 -- us2k10--------
    rs1836711731,2
    --80521160(+) TTAGGC/TGGCTA 2 -- us2k10--------
    rs1421180901,2
    --80521180(+) AAATCA/GGAAAT 2 -- us2k10--------
    rs1884798761,2
    --80521280(+) GCAGCC/TAACTG 2 -- us2k10--------
    rs1812838661,2
    --80521307(+) TAATGC/GCATGA 2 -- us2k10--------
    rs1508900001,2
    C--80521358(+) GAGATA/GACACA 2 -- us2k10--------
    rs1858534831,2
    --80521508(+) AAATGC/TCTATA 2 -- us2k10--------
    rs132511081,2
    C,F--80521516(+) ATATAT/GAGAGA 2 -- us2k19Minor allele frequency- G:0.07NA WA 430
    rs1903915011,2
    --80521549(+) ACCCTG/TCCAAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for STMN2 (80523049 - 80578410 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for STMN2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STMN2
    DNA2.0 Custom Variant and Variant Library Synthesis for STMN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600621    OMIM disorders: --

    12 diseases for STMN2:    
    About MalaCards
    variant creutzfeldt-jakob disease    cervicitis    dysautonomia    down syndrome
    neuronitis    alzheimer's disease    pheochromocytoma    neuroblastoma
    type 1 diabetes    cerebritis    hepatitis    breast cancer


    STMN2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): STMN2

    Export disorders for STMN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STMN2 gene, integrated from 10 sources (see all 89):
    (articles sorted by number of sources associating them with STMN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SCG10, a neuron-specific growth-associated protein in Alzheimer's disease. (PubMed id 8622778)1, 2, 3, 9 Okazaki T.... Mori N. (Neurobiol. Aging 1995)
    2. Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth. (PubMed id 21215777)1, 2 Sobczak A....Wojda U. (Biochim. Biophys. Acta 2011)
    3. KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation. (PubMed id 20621975)1, 2 Alves M.M....Hofstra R.M. (Hum. Mol. Genet. 2010)
    4. Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study. (PubMed id 19081515)1, 4 Mead S....Collinge J. (Lancet Neurol 2009)
    5. BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells. (PubMed id 18452648)1, 2 Gong Y....Yuan J. (BMB Rep. 2008)
    6. Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)1, 2 Gocke C.B.... Kang J. (J. Biol. Chem. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6. (PubMed id 12140291)1, 3 Liu Z....Fisher R.A. (J. Biol. Chem. 2002)
    10. Targeting of SCG10 to the area of the Golgi complex is mediated by its NH2-terminal region. (PubMed id 9030585)1, 9 Di Paolo G....Grenningloh G. (J. Biol. Chem. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11075 HGNC: 10577 AceView: STMN2 Ensembl:ENSG00000104435 euGenes: HUgn11075
    ECgene: STMN2 H-InvDB: STMN2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STMN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for STMN2 gene:
    Search GeneIP for patents involving STMN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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