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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STMN1 Gene

protein-coding   GIFtS: 66
GCID: GC01M026211

Stathmin 1

(Previous names: chromosome 1 open reading frame 215, stathmin 1/oncoprotein...)
(Previous symbols: LAP18, C1orf215)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Stathmin 11 2     PR222
LAP181 2 3 5     metablastin2
C1orf2151 2 3     Phosphoprotein 192
Oncoprotein 181 2 3     prosolin2
Stathmin 1/Oncoprotein 181 2     stathmin2
Leukemia-Associated Phosphoprotein P182 3     Transmembrane Protein C1orf2152
Phosphoprotein P192 3     Metablastin3
OP182 3     Op183
SMN2 5     Prosolin3
Chromosome 1 Open Reading Frame 2151     pp173
Lag2     pp193
PP172     Protein Pr223
PP192     

External Ids:    HGNC: 65101   Entrez Gene: 39252   Ensembl: ENSG000001176327   OMIM: 1514425   UniProtKB: P169493   

Export aliases for STMN1 gene to outside databases

Previous GC identifers: GC01M025706 GC01M025246 GC01M025459 GC01M025831 GC01M025910 GC01M026099 GC01M024466


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STMN1 Gene:
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to
function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded
protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It
prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Feb 2009)

GeneCards Summary for STMN1 Gene: 
STMN1 (stathmin 1) is a protein-coding gene. Diseases associated with STMN1 include ovarian clear cell adenocarcinoma, and clear cell adenocarcinoma, and among its related super-pathways are MAPK signaling pathway and ERK Signaling. GO annotations related to this gene include tubulin binding and signal transducer activity. An important paralog of this gene is STMN3.

UniProtKB/Swiss-Prot: STMN1_HUMAN, P16949
Function: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules.
Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon
formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity)

Gene Wiki entry for STMN1 (Stathmin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STMN1 gene promoter:
         SRF   SRF (504 AA)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): STMN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for STMN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STMN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

STMN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STMN1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M026211:  view genomic region     (about GC identifiers)

Start:
26,210,672 bp from pter      End:
26,233,482 bp from pter
Size:
22,811 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STMN1_HUMAN, P16949 (See protein sequence)
Recommended Name: Stathmin  
Size: 149 amino acids; 17303 Da
Subunit: Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST
Subcellular location: Cytoplasm, cytoskeleton
Secondary accessions: A2A2D1 B2R4E7 B7Z8N4 D3DPJ5
Alternative splicing: 2 isoforms:  P16949-1   P16949-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STMN1: NX_P16949

Explore proteomics data for STMN1 at MOPED 

Post-translational modifications:

  • UniProtKB: Many different phosphorylated forms are observed depending on specific combinations among the sites which can be
    phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at
    Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin
    binding 10-fold and suppresses the MT polymerization inhibition activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P16949

  • STMN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STMN1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001138926.1  NP_005554.1  NP_981944.1  NP_981946.1  

    ENSEMBL proteins: 
     ENSP00000410452   ENSP00000387858   ENSP00000350531   ENSP00000363409   ENSP00000407567  
     ENSP00000382633  

    Human Recombinant Protein Products for STMN1: 
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    OriGene MassSpec for STMN1 
    OriGene Custom Protein Services for STMN1
    GenScript Custom Purified and Recombinant Proteins Services for STMN1
    Novus Biologicals STMN1 Proteins
    Novus Biologicals STMN1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for STMN1
    Cloud-Clone Corp. Proteins for STMN1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--
    GO:0005874microtubule IEA--
    GO:0016020membrane IEA--

    STMN1 for ontologies           About GeneDecksing



    STMN1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of STMN1
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    Cell Signaling Technology (CST) Antibodies for STMN1 
    OriGene Antibodies for STMN1
    OriGene Custom Antibody Services for STMN1
    GenScript Custom Superior Antibodies Services for STMN1
    Novus Biologicals STMN1 Antibodies
    Abcam antibodies for STMN1
    Cloud-Clone Corp. Antibodies for STMN1 
    ThermoFisher Antibody for STMN1
    LSBio Antibodies in human, mouse, rat for STMN1 

    Assay Products for STMN1: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for STMN1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STMN1 
    Cloud-Clone Corp. CLIAs for STMN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000956 Stathmin_fam

    Graphical View of Domain Structure for InterPro Entry P16949

    ProtoNet protein and cluster: P16949

    1 Blocks protein domain: IPB000956 Stathmin

    UniProtKB/Swiss-Prot: STMN1_HUMAN, P16949
    Similarity: Belongs to the stathmin family
    Similarity: Contains 1 SLD (stathmin-like) domain


    STMN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STMN1_HUMAN, P16949
    Function: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules.
    Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon
    formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity)
    Induction: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS2917975
    GO:0005515protein binding ----
    GO:0015631tubulin binding IDA10675326
         
    STMN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for STMN1:
     Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Stmn1):
     cardiovascular system  homeostasis/metabolism  muscle  nervous system  normal 

    STMN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Stmn1tm1Wed for STMN1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for STMN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STMN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STMN1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STMN1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target STMN1:
    hsa-mir-223 (MIRT000129), hsa-mir-30a (MIRT005166)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STMN1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate STMN1:
    hsa-miR-193a-3p hsa-miR-629* hsa-miR-101 hsa-miR-143* hsa-miR-193b
    SwitchGear 3'UTR luciferase reporter plasmidSTMN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STMN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STMN1

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of STMN1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for STMN1 (see all 24)
    OriGene ORF clones in mouse, rat for STMN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): STMN1 (NM_005563)
    Sino Biological Human cDNA Clone for STMN1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STMN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STMN1
    Sirion Biotech Customized lentivirus for stable overexpression of STMN1 
                         Customized lentivirus expression plasmids for stable overexpression of STMN1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for STMN1
    Search LifeMap BioReagents cell lines for STMN1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STMN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STMN1 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Rho Family GTPases
    Rho Family GTPases0.61
    3GPCR Pathway
    Breast Cancer Regulation by Stathmin10.58
    4Signaling mediated by p38-gamma and p38-delta
    Signaling mediated by p38-gamma and p38-delta
    5Regulation of Microtubule Cytoskeleton
    Regulation of Microtubule Cytoskeleton

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for STMN1
        Breast Cancer Regulation by Stathmin1
    Rho Family GTPases

    1 Cell Signaling Technology (CST) Pathway for STMN1
        Cytoskeletal Signaling

    5 BioSystems Pathways for STMN1
        MAPK signaling pathway
    Integrated Pancreatic Cancer Pathway
    Signaling mediated by p38-gamma and p38-delta
    Aurora B signaling
    Regulation of Microtubule Cytoskeleton



    2         Kegg Pathways  (Kegg details for STMN1):
        MAPK signaling pathway
    MicroRNAs in cancer


    STMN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STMN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/28 Interacting proteins for STMN1 (P169492, 3 ENSP000004104524) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEPT2Q150192, 3, ENSP000003531574MINT-8270132 I2D: score=2 STRING: ENSP00000353157
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2860477 I2D: score=3 STRING: ENSP00000357292
    CDKN1BP465273, ENSP000002288724I2D: score=5 STRING: ENSP00000228872
    HSPA5P110213, ENSP000003241734I2D: score=2 STRING: ENSP00000324173
    PRKACAP176123, ENSP000003095914I2D: score=2 STRING: ENSP00000309591
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007019microtubule depolymerization IDA9880330
    GO:0007052mitotic spindle organization IDA9271428
    GO:0007165signal transduction NAS8003023
    GO:0007409axonogenesis IEA--
    GO:0007420brain development IEA--

    STMN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STMN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STMN1

    10/35 Novoseek inferred chemical compound relationships for STMN1 gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    map4 84.1 30 19915797 (4), 19585080 (4), 19228748 (4), 17344472 (3) (see all 10)
    vinblastine 53.1 7 12460900 (2), 11181174 (1), 16940412 (1), 17272681 (1) (see all 6)
    paclitaxel 49.1 23 17670914 (4), 19322891 (3), 10910066 (2), 12460900 (2) (see all 11)
    polyacrylamide 39.3 4 8314790 (1), 9427524 (1), 9324290 (1), 8376365 (1)
    gtp 36.5 16 12606544 (4), 10491392 (3), 10336642 (2), 9880330 (1) (see all 5)
    okt3 35.5 7 1500712 (4), 1376116 (1), 1903411 (1)
    12-o-tetradecanoylphorbol 13-acetate 31.9 7 2116478 (1), 7637391 (1), 15685366 (1), 1727435 (1) (see all 5)
    serine 31 17 19359244 (2), 11922601 (2), 15942644 (1), 16554300 (1) (see all 10)
    nocodazole 25 1 8612695 (1)
    gdp 20.2 2 18084788 (1), 11015208 (1)

    Search CenterWatch for drugs/clinical trials and news about STMN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STMN1 gene (5 alternative transcripts): 
    NM_001145454.1  NM_005563.3  NM_203399.1  NM_203401.1  NM_152497.1  

    Unigene Cluster for STMN1:

    Stathmin 1
    Hs.209983  [show with all ESTs]
    Unigene Representative Sequence: BX647885
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513116(uc001bky.3 uc010oev.2) ENST00000426559 ENST00000455785(uc001bla.3 uc001blb.3 uc001blc.3)
    ENST00000465604 ENST00000357865 ENST00000374291 ENST00000485226 ENST00000446334
    ENST00000399728(uc001bkz.3)

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate STMN1:
    hsa-miR-193a-3p hsa-miR-629* hsa-miR-101 hsa-miR-143* hsa-miR-193b
    SwitchGear 3'UTR luciferase reporter plasmidSTMN1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Clone
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    OriGene clones in human, mouse for STMN1 (see all 24)
    OriGene ORF clones in mouse, rat for STMN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): STMN1 (NM_005563)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STMN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STMN1
    Sirion Biotech Customized lentivirus for stable overexpression of STMN1 
                         Customized lentivirus expression plasmids for stable overexpression of STMN1 
    Primer
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    OriGene qPCR primer pairs and template standards for STMN1
    OriGene qSTAR qPCR primer pairs in human, mouse for STMN1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STMN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STMN1

    Additional mRNA sequence: 

    AB209282.1 AB451319.1 AB451448.1 AK054594.1 AK056768.1 AK303692.1 AK311801.1 BC014353.1 
    BC023313.1 BC028398.1 BC082228.1 BC114443.1 BC114502.1 BX647885.1 J04991.1 X53305.1 
    Z11566.1 

    24/54 DOTS entries (see all 54):

    DT.100039637  DT.450940  DT.100687662  DT.100639338  DT.100687676  DT.100687669  DT.100639144  DT.100709091 
    DT.100875768  DT.40117121  DT.121432258  DT.87016971  DT.95186534  DT.91834489  DT.95186568  DT.87016973 
    DT.95186438  DT.91778774  DT.100039634  DT.100737007  DT.95186394  DT.95186432  DT.95186566  DT.100687666 

    24/1641 AceView cDNA sequences (see all 1641):

    AA442903 CB130165 BM474650 BG766567 BM469480 BE888646 BE880279 CR611894 
    BQ930187 BM471683 AL552832 BF916331 BQ947172 CA775271 BE729056 F10509 
    BQ218465 BM746934 AL561484 CR607751 BU931882 BP366939 AK054594 T29846 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for STMN1 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
    SP1:        -     -     -     -     -     -     -                                                                                       
    SP2:                    -     -     -     -     -                                                                                       
    SP3:                                -     -     -                                                                                       
    SP4:                                      -     -                                                                                       
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for STMN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STMN1 expression in normal human tissues (normalized intensities)      STMN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCTGAGGT
    STMN1 Expression
    About this image


    STMN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Brain (Nervous System)    fully expand to see all 23 entries
             Thalamus
             Olfactory Bulb   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 5 entries
             colon ; peripheral nerve/ganglion   
             autonomic/sympathetic/ganglion   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; endothelial cells   
     
     Uterus
             uterus, pre-menopause ; glandular cells   
     
     Epithelium (Reproductive System)    fully expand to see all 4 entries
             vagina ; squamous epithelial cells   

    See STMN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STMN1

    SOURCE GeneReport for Unigene cluster: Hs.209983

    UniProtKB/Swiss-Prot: STMN1_HUMAN, P16949
    Tissue specificity: Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum,
    followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta,
    uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest
    expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia
    of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells,
    bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for STMN1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stmn11 , 5 stathmin 11, 5 89.04(n)1
    98.66(a)1
      4 (66.76 cM)5
    167651  NM_019641.41  NP_062615.11 
     1344683205 
    chicken
    (Gallus gallus)
    Aves STMN11 stathmin 1 87.27(n)
    95.14(a)
      396057  NM_001001858.1  NP_001001858.1 
    lizard
    (Anolis carolinensis)
    Reptilia STMN16
    Stathmin
    81(a)
    1 ↔ 1
    GL343480.1(173848-182125)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054159.12   -- 77.95(n)    BC054159.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stmn1a1 stathmin 1a 74.29(n)
    80(a)
      678630  NM_001040375.1  NP_001035465.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta stai6
    stathmin
    12(a)
    1 → many
    2L(6100377-6124653)


    ENSEMBL Gene Tree for STMN1 (if available)
    TreeFam Gene Tree for STMN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STMN1 gene
    STMN32  STMN22  STMN42  
    3 SIMAP similar genes for STMN1 using alignment to 4 protein entries:     STMN1_HUMAN (see all proteins):
    STMN4    STMN2    STMN3

    STMN1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for STMN1
    PGOHUM00000239395 PGOHUM00000245706


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/447 SNPs in STMN1 are shown (see all 447)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1878966911,2
    --26210280(+) GAGGTA/CAACTT 1 -- ds50010--------
    rs769891851,2
    --26210392(+) AACATA/GGTGAG 1 -- ds50010--------
    rs1425586501,2
    C--26210750(+) TTCCTC/GAGGCT 1 -- ut310--------
    rs1595301,2
    C,F,A,H--26210791(-) TGAACG/ATACCC 1 -- ut3125Minor allele frequency- A:0.40NS EA NA WA CSA 2532
    rs1509704821,2
    --26210983(+) GAGATC/TGAGAC 1 -- ut310--------
    rs1896847341,2
    --26211015(+) ACCCCA/GTCTCT 1 -- ut310--------
    rs1823600151,2
    --26211043(+) TAAGCC/TGGGCG 1 -- ut310--------
    rs1407798321,2
    C--26211079(+) CTACTC/TGGGAG 1 -- ut310--------
    rs342618061,2
    C--26211206(+) AAAAAG/AAAGAG 1 -- ut311Minor allele frequency- A:0.00NA 2
    rs3686952641,2
    C--26211206(+) AAAAA-/AGAGAG 2 -- ut311Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for STMN1 (26210672 - 26233482 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for STMN1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834491CNV Loss17160897
    nsv460884CNV Loss19166990
    nsv834502CNV Gain17160897
    nsv871062CNV Gain21882294


    Human Gene Mutation Database (HGMD): STMN1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 151442    OMIM disorders: --

    20/64 diseases for STMN1 (see all 64):    About MalaCards
    ovarian clear cell adenocarcinoma    clear cell adenocarcinoma    anaplastic oligodendroglioma    plasmacytoma
    pancreatic ductal carcinoma    oligodendroglioma    polyploidy    brain cancer
    prostate adenocarcinoma    leukemia    acute leukemia    visceral leishmaniasis
    eating disorder    paraganglioma    adenoid cystic carcinoma    adenoiditis
    familial breast cancer    medulloblastoma    leishmaniasis    laryngeal squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for STMN1:
    Cancer

    STMN1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/41 Novoseek inferred disease relationships for STMN1 gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 38.7 27 8412315 (4), 1917919 (3), 9324290 (2), 18262179 (1) (see all 14)
    acute leukemia 38.1 16 1917919 (3), 1401087 (2), 8412315 (2), 9324290 (2) (see all 7)
    medulloblastoma 37.3 2 15126347 (1), 19569914 (1)
    anaplastic oligodendroglioma 35.3 1 17440165 (1)
    tumors 33.5 80 17663418 (5), 18461287 (4), 7638082 (3), 17440165 (3) (see all 35)
    cancer 32.6 32 12415323 (3), 17172428 (2), 11258620 (2), 16909102 (2) (see all 19)
    erythroleukemia 21.6 2 11922601 (2)
    breast cancer 18.5 19 12460900 (4), 17272681 (4), 17874182 (1), 19925864 (1) (see all 10)
    leukemia t-cell 17.1 1 15363129 (1)
    osteosarcoma 14.7 16 17873971 (5), 15142441 (3), 8003023 (2)

    Genetic Association Database (GAD): STMN1
    Human Genome Epidemiology (HuGE) Navigator: STMN1 (6 documents)

    Export disorders for STMN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STMN1 gene, integrated from 9 sources (see all 349):
    (articles sorted by number of sources associating them with STMN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcriptional and post-transcriptional regulation of pr22 (Op18) with proliferation control. (PubMed id 8906359)1, 2, 9 Hosoya H.... Marunouchi T. (1996)
    2. Multiple signal transduction pathways induce phosphorylation of serines 16, 25, and 38 of oncoprotein 18 in T lymphocytes. (PubMed id 8245003)1, 2, 9 Marklund U.... Gullberg M. (1993)
    3. Cell-cycle-regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38. (PubMed id 8125092)1, 2, 9 Brattsand G.... Gullberg M. (1994)
    4. Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase. (PubMed id 8325880)1, 2, 9 Marklund U.... Gullberg M. (1993)
    5. Characterization of the gene for a proliferation-related phosphoprotein (oncoprotein 18) expressed in high amounts in acute leukemia. (PubMed id 1917919)1, 2, 9 Melhem R.F.... Hanash S.M. (1991)
    6. Op18/stathmin caps a kinked protofilament-like tubulin tetramer. (PubMed id 10675326)1, 2, 9 Steinmetz M.O....van Oostrum J. (2000)
    7. Probing the native structure of stathmin and its interaction domains with tubulin. Combined use of limited proteolysis, size exclusion chromatography, and mass spectrometry. (PubMed id 10702243)1, 2, 9 Redeker V.... Curmi P.A. (2000)
    8. Expression of stathmin family genes in human tissues: non-neural- restricted expression for SCLIP. (PubMed id 12676564)1, 2, 9 Bieche I.... Curmi P.A. (2003)
    9. Stathmin, a gene regulating neural plasticity, affect s fear and anxiety processing in humans. (PubMed id 19526456)1, 4 Brocke B....Kirschbaum C. (2010)
    10. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3925 HGNC: 6510 AceView: STMN1 Ensembl:ENSG00000117632 euGenes: HUgn3925
    ECgene: STMN1 Kegg: 3925 H-InvDB: STMN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STMN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STMN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STMN1 gene:
    Search GeneIP for patents involving STMN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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