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Aliases for STMN1 Gene

Aliases for STMN1 Gene

  • Stathmin 1 2 3
  • Oncoprotein 18 2 3 4
  • LAP18 3 4 6
  • Leukemia-Associated Phosphoprotein P18 3 4
  • Stathmin 1/Oncoprotein 18 2 3
  • Phosphoprotein P19 3 4
  • Metablastin 3 4
  • Prosolin 3 4
  • C1orf215 3 4
  • PP17 3 4
  • PP19 3 4
  • OP18 3 4
  • SMN 3 6
  • Chromosome 1 Open Reading Frame 215 2
  • Transmembrane Protein C1orf215 3
  • Phosphoprotein 19 3
  • Protein Pr22 4
  • Stathmin 3
  • PR22 3
  • Lag 3

External Ids for STMN1 Gene

Previous HGNC Symbols for STMN1 Gene

  • LAP18
  • C1orf215

Previous GeneCards Identifiers for STMN1 Gene

  • GC01M025706
  • GC01M025246
  • GC01M025459
  • GC01M025831
  • GC01M025910
  • GC01M026099
  • GC01M026211
  • GC01M024466

Summaries for STMN1 Gene

Entrez Gene Summary for STMN1 Gene

  • This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

GeneCards Summary for STMN1 Gene

STMN1 (Stathmin 1) is a Protein Coding gene. Diseases associated with STMN1 include ovarian clear cell adenocarcinoma and clear cell adenocarcinoma. Among its related pathways are MAPK signaling pathway and ERK Signaling. GO annotations related to this gene include signal transducer activity and tubulin binding. An important paralog of this gene is STMN2.

UniProtKB/Swiss-Prot for STMN1 Gene

  • Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).

Gene Wiki entry for STMN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STMN1 Gene

Genomics for STMN1 Gene

Regulatory Elements for STMN1 Gene

Transcription factor binding sites by QIAGEN in the STMN1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STMN1 Gene

Start:
25,884,181 bp from pter
End:
25,906,991 bp from pter
Size:
22,811 bases
Orientation:
Minus strand

Genomic View for STMN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STMN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STMN1 Gene

Proteins for STMN1 Gene

  • Protein details for STMN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16949-STMN1_HUMAN
    Recommended name:
    Stathmin
    Protein Accession:
    P16949
    Secondary Accessions:
    • A2A2D1
    • B2R4E7
    • B7Z8N4
    • D3DPJ5

    Protein attributes for STMN1 Gene

    Size:
    149 amino acids
    Molecular mass:
    17303 Da
    Quaternary structure:
    • Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.

    Alternative splice isoforms for STMN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STMN1 Gene

Proteomics data for STMN1 Gene at MOPED

Post-translational modifications for STMN1 Gene

  • Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.
  • Ubiquitination at Lys9, Lys29, Lys52, Lys70, Lys85, Lys95, Lys119, Lys137, and Lys140
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STMN1 (STMN1)

No data available for DME Specific Peptides for STMN1 Gene

Domains for STMN1 Gene

Protein Domains for STMN1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STMN1 Gene

Graphical View of Domain Structure for InterPro Entry

P16949

UniProtKB/Swiss-Prot:

STMN1_HUMAN :
  • P16949
Domain:
  • Contains 1 SLD (stathmin-like) domain.
Family:
  • Belongs to the stathmin family.
genes like me logo Genes that share domains with STMN1: view

No data available for Gene Families for STMN1 Gene

Function for STMN1 Gene

Molecular function for STMN1 Gene

UniProtKB/Swiss-Prot Function: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
UniProtKB/Swiss-Prot Induction: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Gene Ontology (GO) - Molecular Function for STMN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 2917975
GO:0005515 protein binding IPI 25416956
GO:0015631 tubulin binding IDA 10675326
genes like me logo Genes that share ontologies with STMN1: view
genes like me logo Genes that share phenotypes with STMN1: view

Animal Models for STMN1 Gene

MGI Knock Outs for STMN1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STMN1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for STMN1 Gene

Localization for STMN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STMN1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STMN1 Gene COMPARTMENTS Subcellular localization image for STMN1 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for STMN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IEA --
GO:0005874 microtubule IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with STMN1: view

Pathways for STMN1 Gene

genes like me logo Genes that share pathways with STMN1: view

Pathways by source for STMN1 Gene

1 Cell Signaling Technology pathway for STMN1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for STMN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007019 microtubule depolymerization IDA 9880330
GO:0007052 mitotic spindle organization IDA 9271428
GO:0007165 signal transduction NAS 8003023
GO:0007409 axonogenesis IEA --
GO:0007420 brain development IEA --
genes like me logo Genes that share ontologies with STMN1: view

Compounds for STMN1 Gene

(35) Novoseek inferred chemical compound relationships for STMN1 Gene

Compound -log(P) Hits PubMed IDs
map4 84.1 21
vinblastine 53.1 7
paclitaxel 49.1 18
polyacrylamide 39.3 4
gtp 36.5 11
genes like me logo Genes that share compounds with STMN1: view

Transcripts for STMN1 Gene

Unigene Clusters for STMN1 Gene

Stathmin 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STMN1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STMN1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5:
SP6: -
SP7: - - - - - -
SP8: -
SP9: -

Relevant External Links for STMN1 Gene

GeneLoc Exon Structure for
STMN1
ECgene alternative splicing isoforms for
STMN1

Expression for STMN1 Gene

mRNA expression in normal human tissues for STMN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STMN1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (5.2), Brain - Anterior cingulate cortex (BA24) (5.0), Brain - Frontal Cortex (BA9) (5.0), and Brain - Cortex (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STMN1 Gene

SOURCE GeneReport for Unigene cluster for STMN1 Gene Hs.209983

mRNA Expression by UniProt/SwissProt for STMN1 Gene

P16949-STMN1_HUMAN
Tissue specificity: Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
genes like me logo Genes that share expressions with STMN1: view

In Situ Assay Products

Orthologs for STMN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for STMN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STMN1 35
  • 99.33 (n)
  • 100 (a)
STMN1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 79 (a)
OneToMany
STMN1 35
  • 93.74 (n)
  • 100 (a)
STMN1 36
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia STMN1 35
  • 93.51 (n)
  • 100 (a)
STMN1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stmn1 35
  • 89.04 (n)
  • 98.66 (a)
Stmn1 16
Stmn1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STMN1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STMN1 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stmn1 35
  • 91.28 (n)
  • 99.33 (a)
chicken
(Gallus gallus)
Aves STMN1 35
  • 87.27 (n)
  • 95.14 (a)
STMN1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STMN1 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stmn1 35
  • 75.63 (n)
  • 78.62 (a)
Str.5945 35
zebrafish
(Danio rerio)
Actinopterygii stmn1a 35
  • 74.29 (n)
  • 80 (a)
stmn1a 36
  • 68 (a)
OneToMany
stmn1b 36
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta stai 36
  • 13 (a)
OneToMany
Species with no ortholog for STMN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STMN1 Gene

ENSEMBL:
Gene Tree for STMN1 (if available)
TreeFam:
Gene Tree for STMN1 (if available)

Paralogs for STMN1 Gene

Paralogs for STMN1 Gene

Selected SIMAP similar genes for STMN1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for STMN1 Gene

genes like me logo Genes that share paralogs with STMN1: view

Variants for STMN1 Gene

Sequence variations from dbSNP and Humsavar for STMN1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs159519 -- 25,897,037(+) TTGCC(A/G)GGCGC intron-variant
rs159520 -- 25,895,265(+) gcccg(G/T)ctaat intron-variant
rs159521 -- 25,894,508(+) aatct(C/T)gtctc intron-variant
rs159522 -- 25,893,357(+) GCTTT(A/G)CAGGG intron-variant
rs159523 -- 25,888,825(-) GAGAC(A/G)TGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STMN1 Gene

Variant ID Type Subtype PubMed ID
nsv834491 CNV Loss 17160897
nsv460884 CNV Loss 19166990
nsv834502 CNV Gain 17160897
nsv871062 CNV Gain 21882294

Relevant External Links for STMN1 Gene

HapMap Linkage Disequilibrium report
STMN1
Human Gene Mutation Database (HGMD)
STMN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STMN1 Gene

Disorders for STMN1 Gene

(1) University of Copenhagen DISEASES for STMN1 Gene

(41) Novoseek inferred disease relationships for STMN1 Gene

Disease -log(P) Hits PubMed IDs
leukemia 38.7 20
acute leukemia 38.1 12
medulloblastoma 37.3 2
anaplastic oligodendroglioma 35.3 1
tumors 33.5 57

Relevant External Links for STMN1

Genetic Association Database (GAD)
STMN1
Human Genome Epidemiology (HuGE) Navigator
STMN1
genes like me logo Genes that share disorders with STMN1: view

No data available for UniProtKB/Swiss-Prot for STMN1 Gene

Publications for STMN1 Gene

  1. Characterization of the gene for a proliferation-related phosphoprotein (oncoprotein 18) expressed in high amounts in acute leukemia. (PMID: 1917919) Melhem R.F. … Hanash S.M. (J. Biol. Chem. 1991) 3 4 23
  2. Cell-cycle-regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38. (PMID: 8125092) Brattsand G. … Gullberg M. (Eur. J. Biochem. 1994) 3 4 23
  3. Multiple signal transduction pathways induce phosphorylation of serines 16, 25, and 38 of oncoprotein 18 in T lymphocytes. (PMID: 8245003) Marklund U. … Gullberg M. (J. Biol. Chem. 1993) 3 4 23
  4. Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase. (PMID: 8325880) Marklund U. … Gullberg M. (J. Biol. Chem. 1993) 3 4 23
  5. Op18/stathmin caps a kinked protofilament-like tubulin tetramer. (PMID: 10675326) Steinmetz M.O. … van Oostrum J. (EMBO J. 2000) 3 4 23

Products for STMN1 Gene

  • Addgene plasmids for STMN1

Sources for STMN1 Gene

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