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Aliases for STMN1 Gene

Aliases for STMN1 Gene

  • Stathmin 1 2 3 5
  • Oncoprotein 18 2 3 4
  • Leukemia-Associated Phosphoprotein P18 3 4
  • Stathmin 1/Oncoprotein 18 2 3
  • Phosphoprotein P19 3 4
  • Metablastin 3 4
  • Prosolin 3 4
  • C1orf215 3 4
  • LAP18 3 4
  • PP17 3 4
  • PP19 3 4
  • OP18 3 4
  • Chromosome 1 Open Reading Frame 215 2
  • Testicular Tissue Protein Li 189 3
  • Transmembrane Protein C1orf215 3
  • Phosphoprotein 19 3
  • Protein Pr22 4
  • Stathmin 3
  • PR22 3
  • SMN 3
  • Lag 3

External Ids for STMN1 Gene

Previous HGNC Symbols for STMN1 Gene

  • LAP18
  • C1orf215

Previous GeneCards Identifiers for STMN1 Gene

  • GC01M025706
  • GC01M025246
  • GC01M025459
  • GC01M025831
  • GC01M025910
  • GC01M026099
  • GC01M026211
  • GC01M024466

Summaries for STMN1 Gene

Entrez Gene Summary for STMN1 Gene

  • This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

CIViC summary for STMN1 Gene

GeneCards Summary for STMN1 Gene

STMN1 (Stathmin 1) is a Protein Coding gene. Diseases associated with STMN1 include Pancreatic Intraductal Papillary-Mucinous Adenoma and Acute Leukemia. Among its related pathways are Aurora B signaling and Immune response IL-23 signaling pathway. GO annotations related to this gene include signal transducer activity and tubulin binding. An important paralog of this gene is STMN2.

UniProtKB/Swiss-Prot for STMN1 Gene

  • Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).

Gene Wiki entry for STMN1 Gene

Additional gene information for STMN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STMN1 Gene

Genomics for STMN1 Gene

Regulatory Elements for STMN1 Gene


Enhancers around STMN1 on UCSC Golden Path with GeneCards custom track

Promoters for STMN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003461 1291 2201 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS

Genomic Location for STMN1 Gene

Chromosome:
1
Start:
25,884,181 bp from pter
End:
25,906,991 bp from pter
Size:
22,811 bases
Orientation:
Minus strand

Genomic View for STMN1 Gene

Genes around STMN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STMN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STMN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STMN1 Gene

Proteins for STMN1 Gene

  • Protein details for STMN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16949-STMN1_HUMAN
    Recommended name:
    Stathmin
    Protein Accession:
    P16949
    Secondary Accessions:
    • A2A2D1
    • B2R4E7
    • B7Z8N4
    • D3DPJ5

    Protein attributes for STMN1 Gene

    Size:
    149 amino acids
    Molecular mass:
    17303 Da
    Quaternary structure:
    • Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.

    Alternative splice isoforms for STMN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STMN1 Gene

Post-translational modifications for STMN1 Gene

  • Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.
  • Ubiquitination at Lys9, posLast=8585, posLast=137137, and posLast=140140
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STMN1 Gene

Domains & Families for STMN1 Gene

Gene Families for STMN1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for STMN1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STMN1 Gene

Graphical View of Domain Structure for InterPro Entry

P16949

UniProtKB/Swiss-Prot:

STMN1_HUMAN :
  • Belongs to the stathmin family.
Family:
  • Belongs to the stathmin family.
genes like me logo Genes that share domains with STMN1: view

Function for STMN1 Gene

Molecular function for STMN1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Phenotypes From GWAS Catalog for STMN1 Gene

Gene Ontology (GO) - Molecular Function for STMN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 2917975
GO:0005515 protein binding IPI 15652749
GO:0015631 tubulin binding IMP 12860982
genes like me logo Genes that share ontologies with STMN1: view
genes like me logo Genes that share phenotypes with STMN1: view

Animal Models for STMN1 Gene

MGI Knock Outs for STMN1:

Animal Model Products

CRISPR Products

miRNA for STMN1 Gene

miRTarBase miRNAs that target STMN1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for STMN1
  • Applied Biological Materials Clones for STMN1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STMN1 Gene

Localization for STMN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STMN1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STMN1 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 3
plasma membrane 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STMN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with STMN1: view

Pathways & Interactions for STMN1 Gene

genes like me logo Genes that share pathways with STMN1: view

Pathways by source for STMN1 Gene

2 KEGG pathways for STMN1 Gene

SIGNOR curated interactions for STMN1 Gene

Gene Ontology (GO) - Biological Process for STMN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 25122120
GO:0007019 microtubule depolymerization IMP,IDA 10675326
GO:0007052 mitotic spindle organization IDA 9271428
GO:0007165 signal transduction NAS 8003023
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with STMN1: view

Drugs & Compounds for STMN1 Gene

(22) Drugs for STMN1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(13) Additional Compounds for STMN1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STMN1: view

Transcripts for STMN1 Gene

Unigene Clusters for STMN1 Gene

Stathmin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for STMN1
  • Applied Biological Materials Clones for STMN1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for STMN1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5:
SP6: -
SP7: - - - - - -
SP8: -
SP9: -

Relevant External Links for STMN1 Gene

GeneLoc Exon Structure for
STMN1
ECgene alternative splicing isoforms for
STMN1

Expression for STMN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STMN1 Gene

mRNA differential expression in normal tissues according to GTEx for STMN1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.2), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Frontal Cortex (BA9) (x5.0), and Brain - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for STMN1 Gene

This gene is overexpressed in Brain (13.6) and Fetal Brain (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STMN1 Gene



Protein tissue co-expression partners for STMN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STMN1 Gene:

STMN1

SOURCE GeneReport for Unigene cluster for STMN1 Gene:

Hs.209983

mRNA Expression by UniProt/SwissProt for STMN1 Gene:

P16949-STMN1_HUMAN
Tissue specificity: Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.

Evidence on tissue expression from TISSUES for STMN1 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Lung(4.8)
  • Kidney(4.5)
  • Skin(4.5)
  • Eye(4.4)
  • Blood(3.9)
  • Lymph node(3.2)
  • Heart(3.1)
  • Intestine(3)
  • Spleen(2.7)
  • Adrenal gland(2.4)
  • Bone marrow(2.4)
  • Bone(2.2)
  • Pancreas(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with STMN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for STMN1 Gene

Orthologs for STMN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for STMN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STMN1 33 34
  • 99.33 (n)
cow
(Bos Taurus)
Mammalia STMN1 33 34
  • 93.74 (n)
-- 34
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia STMN1 33 34
  • 93.51 (n)
rat
(Rattus norvegicus)
Mammalia Stmn1 33
  • 91.28 (n)
mouse
(Mus musculus)
Mammalia Stmn1 33 16 34
  • 89.04 (n)
oppossum
(Monodelphis domestica)
Mammalia STMN1 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STMN1 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves STMN1 33 34
  • 87.27 (n)
lizard
(Anolis carolinensis)
Reptilia STMN1 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stmn1 33
  • 75.63 (n)
Str.5945 33
zebrafish
(Danio rerio)
Actinopterygii stmn1a 33 34
  • 74.29 (n)
stmn1b 34
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta stai 34
  • 13 (a)
OneToMany
Species where no ortholog for STMN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STMN1 Gene

ENSEMBL:
Gene Tree for STMN1 (if available)
TreeFam:
Gene Tree for STMN1 (if available)

Paralogs for STMN1 Gene

Paralogs for STMN1 Gene

(3) SIMAP similar genes for STMN1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for STMN1 Gene

genes like me logo Genes that share paralogs with STMN1: view

Variants for STMN1 Gene

Sequence variations from dbSNP and Humsavar for STMN1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000562532 -- 25,895,585(+) CAAGG(A/G)GGCAG intron-variant
rs1000875160 -- 25,907,396(+) GCAAA(A/G)GCACA nc-transcript-variant, upstream-variant-2KB
rs1000887262 -- 25,889,192(+) TCACC(A/G)TTATC intron-variant
rs1000918232 -- 25,889,497(+) AGCTC(C/T)CCAAG intron-variant
rs1000939569 -- 25,906,886(+) AGTGC(A/C/G)CCACC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for STMN1 Gene

Variant ID Type Subtype PubMed ID
nsv460884 CNV loss 19166990
nsv545883 CNV loss 21841781
nsv834491 CNV loss 17160897
nsv834502 CNV gain 17160897
nsv945838 CNV duplication 23825009

Variation tolerance for STMN1 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STMN1 Gene

Human Gene Mutation Database (HGMD)
STMN1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STMN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STMN1 Gene

Disorders for STMN1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for STMN1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pancreatic intraductal papillary-mucinous adenoma
acute leukemia
  • stem cell leukaemia
agoraphobia
  • fear of open spaces
humeroradial synostosis
  • humero-radial fusion
ovarian clear cell adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search STMN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STMN1

Genetic Association Database (GAD)
STMN1
Human Genome Epidemiology (HuGE) Navigator
STMN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STMN1
genes like me logo Genes that share disorders with STMN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STMN1 Gene

Publications for STMN1 Gene

  1. Op18/stathmin caps a kinked protofilament-like tubulin tetramer. (PMID: 10675326) Steinmetz MO … van Oostrum J (The EMBO journal 2000) 3 4 22 60
  2. Probing the native structure of stathmin and its interaction domains with tubulin. Combined use of limited proteolysis, size exclusion chromatography, and mass spectrometry. (PMID: 10702243) Redeker V … Curmi PA (The Journal of biological chemistry 2000) 3 4 22 60
  3. Transcriptional and post-transcriptional regulation of pr22 (Op18) with proliferation control. (PMID: 8906359) Hosoya H … Marunouchi T (Cell structure and function 1996) 3 4 22 60
  4. Cell-cycle-regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38. (PMID: 8125092) Brattsand G … Gullberg M (European journal of biochemistry 1994) 3 4 22 60
  5. Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase. (PMID: 8325880) Marklund U … Gullberg M (The Journal of biological chemistry 1993) 3 4 22 60

Products for STMN1 Gene

  • Addgene plasmids for STMN1

Sources for STMN1 Gene

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