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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STMN1 Gene

protein-coding   GIFtS: 64
GCID: GC01M026211

stathmin 1

(Previous names: chromosome 1 open reading frame 215, stathmin 1/oncoprotein...)
(Previous symbols: LAP18, C1orf215)
 Explore 71 diseases affiliated with
STMN1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STMN1    

Aliases
for STMN1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Stathmin 11 2     FLJ322061
LAP181 2 3 5     Chromosome 1 Open Reading Frame 2151
C1orf2151 2 3     Metablastin3
OP181 2 3     Phosphoprotein 192
SMN1 2 5     Prosolin3
Lag1 2     Stathmin1
PP171 2     Transmembrane Protein C1orf2152
PP191 2     Metablastin3
PR221 2     Op183
Stathmin 1/Oncoprotein 181 2     Prosolin3
Leukemia-Associated Phosphoprotein P182 3     Pp171
Oncoprotein 182 3     Pp191
Phosphoprotein P192 3     Protein Pr223

External Ids:    HGNC: 65101   Entrez Gene: 39252   Ensembl: ENSG000001176327   OMIM: 1514425   UniProtKB: P169493   

Export aliases for STMN1 gene to outside databases

Previous GC identifers: GC01M025706 GC01M025246 GC01M025459 GC01M025831 GC01M025910 GC01M026099 GC01M024466


Summaries
for STMN1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for STMN1:
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to
function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is
involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and
promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: STMN1_HUMAN, P16949
Function: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents
assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during
neurogenesis. Involved in the control of the learned and innate fear (By similarity)

Gene Wiki entry for STMN1 (Stathmin)


Genomic Views
for STMN1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STMN1 gene promoter:
         SRF   SRF (504 AA)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): STMN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for STMN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STMN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

STMN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STMN1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M026211:  view genomic region     (about GC identifiers)

Start:
 26,210,672 bp from pter      End:
 26,233,482 bp from pter
Size:
 22,811 bases      Orientation:
 minus strand

Proteins
for STMN1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STMN1_HUMAN, P16949 (See protein sequence)
Recommended Name: Stathmin  
Size: 149 amino acids; 17303 Da
Subunit: Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST
Subcellular location: Cytoplasm, cytoskeleton
Secondary accessions: A2A2D1 B2R4E7 B7Z8N4 D3DPJ5
Alternative splicing: 2 isoforms:  P16949-1   P16949-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STMN1: NX_P16949

Post-translational modifications:

  • Many different phosphorylated forms are observed depending on specific combinations among the sites which can be
    • phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16
    seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding
    10-fold and suppresses the MT polymerization inhibition activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P16949

    • STMN1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001138926.1  NP_005554.1  NP_981944.1  NP_981946.1  

    ENSEMBL proteins: 
     ENSP00000410452   ENSP00000387858   ENSP00000350531   ENSP00000363409   ENSP00000407567  
     ENSP00000382633  

    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 3): STMN1
    OriGene Protein Over-expression Lysate (see all 4): STMN1
    OriGene Custom Protein Services for STMN1 
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    Novus Biologicals STMN1 Proteins
    Novus Biologicals STMN1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for STMN1
    Uscn Proteins for STMN1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--
    GO:0005874microtubule IEA--


    STMN1 for ontologies           About GeneDecksing



    STMN1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of STMN1
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    OriGene Antibodies (see all 9): STMN1
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    GenScript Custom Superior Antibodies Services for STMN1
    Novus Biologicals STMN1 Antibodies
    Abcam antibodies for STMN1 
    Uscn Antibodies for STMN1
    ThermoFisher Antibody for STMN1

    Assay Products for STMN1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STMN1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for STMN1

    Protein Domains /
    Families
    for STMN1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STMN1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000956 Stathmin_fam

    Graphical View of Domain Structure for InterPro Entry P16949

    ProtoNet protein and cluster: P16949

    1 Blocks protein family: IPB000956 Stathmin

    UniProtKB/Swiss-Prot: STMN1_HUMAN, P16949
    Similarity: Belongs to the stathmin family
    Similarity: Contains 1 SLD (stathmin-like) domain


    Function
    for STMN1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STMN1_HUMAN, P16949
    Function: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents
    assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during
    neurogenesis. Involved in the control of the learned and innate fear (By similarity)
    Induction: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level)

    miRNA
    Products:            		miRTarBase miRNAs that target STMN1:
    hsa-mir-223 (MIRT000129), hsa-mir-30a (MIRT005166)

    OriGene 3'-UTR Clone (see all 4): STMN1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STMN1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate STMN1:
    hsa-miR-193a-3p hsa-miR-629* hsa-miR-101 hsa-miR-143* hsa-miR-193b
    SwitchGear 3'UTR luciferase reporter plasmid: STMN1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STMN1 (see all 7)
    OriGene shRNA RFP: STMN1
    OriGene siRNA: STMN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STMN1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for STMN1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STMN1 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STMN1 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): STMN1 (NM_005563)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STMN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STMN1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for STMN1
    Search LifeMap BioReagents cell lines for STMN1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STMN1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS8003023
    GO:0005515protein binding ----
    GO:0015631tubulin binding IDA10675326


    STMN1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for STMN1:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Stmn1tm1Wed for STMN1
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Stmn1):
     cardiovascular system  homeostasis/metabolism  muscle  nervous system  normal 

    STMN1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for STMN1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MAPK signaling pathway
    		MAPK signaling pathway1.00
    		MAPK signaling pathway0.50
    2Integrated Pancreatic Cancer Pathway
    		Integrated Pancreatic Cancer Pathway1.00
    		Integrated Pancreatic Cancer Pathway0.99
    3Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00
    4Rho Family GTPases
    		Rho Family GTPases1.00
    5Aurora B signaling
    		Aurora B signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for STMN1
        Breast Cancer Regulation by Stathmin1
    Rho Family GTPases

    1 Cell Signaling Technology (CST) Pathway for STMN1
        Cytoskeletal Signaling

    5 BioSystems Pathways for STMN1 
        MAPK signaling pathway
    Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    Signaling mediated by p38-gamma and p38-delta
    Aurora B signaling


    1         Kegg Pathway  (Kegg details for STMN1):
        MAPK signaling pathway


    STMN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STMN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/28 Interacting proteins for STMN1 (P169492, 3 ENSP000004104524) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEPT2Q150192, 3, ENSP000003531574MINT-8270132 I2D: score=2 STRING: ENSP00000353157
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2860477 I2D: score=3 STRING: ENSP00000357292
    CDKN1BP465273, ENSP000002288724I2D: score=5 STRING: ENSP00000228872
    HSPA5P110213, ENSP000003241734I2D: score=2 STRING: ENSP00000324173
    PRKACAP176123, ENSP000003095914I2D: score=2 STRING: ENSP00000309591
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007019microtubule depolymerization IDA9880330
    GO:0007052mitotic spindle organization IDA9271428
    GO:0007165signal transduction NAS8003023
    GO:0007399nervous system development ----
    GO:0007409axonogenesis IEA--


    STMN1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for STMN1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STMN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STMN1
    10/35 Novoseek chemical compound relationships for STMN1 gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    map4 84.1 30 19915797 (4), 19585080 (4), 19228748 (4), 17344472 (3) (see all 10)
    vinblastine 53.1 7 12460900 (2), 11181174 (1), 16940412 (1), 17272681 (1) (see all 6)
    paclitaxel 49.1 23 17670914 (4), 19322891 (3), 10910066 (2), 12460900 (2) (see all 11)
    polyacrylamide 39.3 4 8314790 (1), 9427524 (1), 9324290 (1), 8376365 (1)
    gtp 36.5 16 12606544 (4), 10491392 (3), 10336642 (2), 9880330 (1) (see all 5)
    okt3 35.5 7 1500712 (4), 1376116 (1), 1903411 (1)
    12-o-tetradecanoylphorbol 13-acetate 31.9 7 2116478 (1), 7637391 (1), 15685366 (1), 1727435 (1) (see all 5)
    serine 31 17 19359244 (2), 11922601 (2), 15942644 (1), 16554300 (1) (see all 10)
    nocodazole 25 1 8612695 (1)
    gdp 20.2 2 18084788 (1), 11015208 (1)

    Search CenterWatch for drugs/clinical trials and news about STMN1 

    Transcripts
    for STMN1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STMN1 gene (5 alternative transcripts): 
    NM_001145454.1  NM_005563.3  NM_203399.1  NM_203401.1  NM_152497.1  

    Unigene Cluster for STMN1:

    Stathmin 1
    Hs.209983  [show with all ESTs]
    Unigene Representative Sequence: BX647885
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513116(uc001bky.3 uc010oev.2) ENST00000426559 ENST00000455785(uc001bla.3 uc001blb.3 uc001blc.3)
    ENST00000465604 ENST00000357865 ENST00000374291 ENST00000485226 ENST00000446334
    ENST00000399728(uc001bkz.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): STMN1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STMN1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate STMN1:
    hsa-miR-193a-3p hsa-miR-629* hsa-miR-101 hsa-miR-143* hsa-miR-193b
    SwitchGear 3'UTR luciferase reporter plasmid: STMN1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STMN1 (see all 7)
    OriGene shRNA RFP: STMN1
    OriGene siRNA: STMN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STMN1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STMN1 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STMN1 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): STMN1 (NM_005563)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STMN1 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STMN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STMN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STMN1

    Additional cDNA sequence: 

    AB209282.1 AB451319.1 AB451448.1 AK054594.1 AK056768.1 AK303692.1 AK311801.1 BC014353.1 
    BC023313.1 BC028398.1 BC082228.1 BC114443.1 BC114502.1 BX647885.1 J04991.1 X53305.1 
    Z11566.1 

    24/54 DOTS entries (see all 54):

    DT.100039637  DT.450940  DT.100687662  DT.100639338  DT.100687676  DT.100687669  DT.100639144  DT.100709091 
    DT.100875768  DT.40117121  DT.121432258  DT.87016971  DT.95186534  DT.91834489  DT.95186568  DT.87016973 
    DT.95186438  DT.91778774  DT.100039634  DT.100737007  DT.95186394  DT.95186432  DT.95186566  DT.100687666 

    24/1641 AceView cDNA sequences (see all 1641):

    BM312009 BE871519 CR598511 BE259238 CB122087 CB123068 BM800904 CB122769 
    CB215565 BE888080 BU164918 BE908186 AA837520 T16580 AL552832 BU627121 
    BE889662 BQ018988 BP367085 AA380520 BE252273 BE888646 BM852384 CB154917 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for STMN1 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
    SP1:        -     -     -     -     -     -     -                                                                                       
    SP2:                    -     -     -     -     -                                                                                       
    SP3:                                -     -     -                                                                                       
    SP4:                                      -     -                                                                                       
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for STMN1

    Expression
    for STMN1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STMN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGCTGAGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    STMN1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    EyeRetinaEye
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See STMN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STMN1

    SOURCE GeneReport for Unigene cluster: Hs.209983

    UniProtKB/Swiss-Prot: STMN1_HUMAN, P16949
    Tissue specificity: Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed
    by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and
    trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is
    found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different
    subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or
    cells from patients with chronic lymphoid or myeloid leukemia

        SABiosciences Expression via Pathway-Focused PCR Arrays including STMN1: 
              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat
              Cancer PathwayFinder in human mouse rat

    Primer
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    Orthologs
    for STMN1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for STMN1 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves STMN11 stathmin 1 87.27(n)
    95.14(a)    		   396057  NM_001001858.1  NP_001001858.1 
    lizard
    (Anolis carolinensis)    		 Reptilia STMN16
    		 --
    		 81(a)
    		 1 ↔ 1
    		 GL343480.1(175648-177902)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC054159.12   -- 77.95(n)    BC054159.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii stmn1a1 stathmin 1a 74.29(n)
    80(a)    		   678630  NM_001040375.1  NP_001035465.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta stai6
    		 stathmin
    		 11(a)
    		 1 → many
    		 2L(6100377-6124653)


    ENSEMBL Gene Tree for STMN1 (if available)
    TreeFam Gene Tree for STMN1 (if available) 

    Paralogs
    for STMN1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STMN1 gene
    STMN32  STMN22  STMN42  
    3 SIMAP similar genes for STMN1 using alignment to 4 protein entries:     STMN1_HUMAN (see all proteins):
    STMN4    STMN2    STMN3

    STMN1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for STMN1
    PGOHUM00000239395 PGOHUM00000245706


    Genomic Variants
    for STMN1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/392 NCBI SNPs in STMN1 are shown (see all 392)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1878966911,2
    		--26210280(+) GAGGTA/CAACTT 1 -- ds50010--------
    rs769891851,2
    		--26210392(+) AACATA/GGTGAG 1 -- ds50010--------
    rs1425586501,2
    		--26210750(+) TTCCTC/GAGGCT 1 -- ut310--------
    rs1595301,2
    		C,F,A,H,--26210791(-) TGAACG/ATACCC 1 -- ut3125Minor allele frequency- A:0.40NS EA NA WA CSA 2532
    rs1509704821,2
    		--26210983(+) GAGATC/TGAGAC 1 -- ut310--------
    rs1896847341,2
    		--26211015(+) ACCCCA/GTCTCT 1 -- ut310--------
    rs1823600151,2
    		--26211043(+) TAAGCC/TGGGCG 1 -- ut310--------
    rs1407798321,2
    		--26211079(+) CTACTC/TGGGAG 1 -- ut310--------
    rs1138896291,2
    		C,--26211207(+) AAAAAG/AAGAGA 1 -- ut311Minor allele frequency- A:0.00NA 2
    rs75334801,2
    		C,F,H,--26211392(+) GACTCC/GTGCCC 1 -- ut317Minor allele frequency- G:0.02NS EA NA WA 542

    HapMap Linkage Disequilibrium report for STMN1 (26210672 - 26233482 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for STMN1: --
    Human Gene Mutation Database (HGMD): STMN1

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    Disorders / Diseases
    for STMN1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STMN1 for disorders           About GeneDecksing

    OMIM gene information: 151442    OMIM disorders: --

    20/71 diseases for STMN1 (see all 71):    About MalaCards
    leukemia    anaplastic oligodendroglioma    clear cell adenocarcinoma    ovarian clear cell adenocarcinoma
    visceral leishmaniasis    squamous cell carcinoma    spontaneous abortion    laryngeal squamous cell carcinoma
    adenoid cystic carcinoma    oral squamous cell carcinoma    plasmacytoma    oligodendroglioma
    anorexia nervosa    eating disorder    multiple sclerosis    pancreatic ductal carcinoma
    malignant mesothelioma    lymphoblastic leukemia    carcinoma    leukemia/lymphoma

    1 disease from the University of Copenhagen DISEASES database for STMN1:
    Cancer

    10/41 Novoseek disease relationships for STMN1 gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 38.7 27 8412315 (4), 1917919 (3), 9324290 (2), 18262179 (1) (see all 14)
    acute leukemia 38.1 16 1917919 (3), 1401087 (2), 8412315 (2), 9324290 (2) (see all 7)
    medulloblastoma 37.3 2 15126347 (1), 19569914 (1)
    anaplastic oligodendroglioma 35.3 1 17440165 (1)
    tumors 33.5 80 17663418 (5), 18461287 (4), 7638082 (3), 17440165 (3) (see all 35)
    cancer 32.6 32 12415323 (3), 17172428 (2), 11258620 (2), 16909102 (2) (see all 19)
    erythroleukemia 21.6 2 11922601 (2)
    breast cancer 18.5 19 12460900 (4), 17272681 (4), 17874182 (1), 19925864 (1) (see all 10)
    leukemia t-cell 17.1 1 15363129 (1)
    osteosarcoma 14.7 16 17873971 (5), 15142441 (3), 8003023 (2)

    Human Genome Epidemiology (HuGE) Navigator: STMN1 (6 documents)

    Export disorders for STMN1 gene to outside databases

    Publications
    for STMN1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STMN1 gene, integrated from 9 sources (see all 333):
    (articles sorted by number of sources associating them with STMN1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcriptional and post-transcriptional regulation of pr22 (Op18) with proliferation control. (PubMed id 8906359)1, 2, 9 Hosoya H.... Marunouchi T. (1996)
    2. Multiple signal transduction pathways induce phosphorylation of serines 16, 25, and 38 of oncoprotein 18 in T lymphocytes. (PubMed id 8245003)1, 2, 9 Marklund U.... Gullberg M. (1993)
    3. Cell-cycle-regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38. (PubMed id 8125092)1, 2, 9 Brattsand G.... Gullberg M. (1994)
    4. Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase. (PubMed id 8325880)1, 2, 9 Marklund U.... Gullberg M. (1993)
    5. Characterization of the gene for a proliferation-related phosphoprotein (oncoprotein 18) expressed in high amounts in acute leukemia. (PubMed id 1917919)1, 2, 9 Melhem R.F.... Hanash S.M. (1991)
    6. Op18/stathmin caps a kinked protofilament-like tubulin tetramer. (PubMed id 10675326)1, 2, 9 Steinmetz M.O....van Oostrum J. (2000)
    7. Probing the native structure of stathmin and its interaction domains with tubulin. Combined use of limited proteolysis, size exclusion chromatography, and mass spectrometry. (PubMed id 10702243)1, 2, 9 Redeker V.... Curmi P.A. (2000)
    8. Expression of stathmin family genes in human tissues: non-neural- restricted expression for SCLIP. (PubMed id 12676564)1, 2, 9 Bieche I.... Curmi P.A. (2003)
    9. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)1, 2 Leong W.F. and Chow V.T. (2006)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)

    External Searches for STMN1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing STMN1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3925 HGNC: 6510 AceView: STMN1 Ensembl:ENSG00000117632 euGenes: HUgn3925
    ECgene: STMN1 Kegg: 3925 H-InvDB: STMN1

    Other Databases showing STMN1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STMN1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STMN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STMN1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for STMN1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STMN1 gene:
    Search GeneIP for patents involving STMN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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