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Aliases for STKLD1 Gene

Aliases for STKLD1 Gene

  • Serine/Threonine Kinase Like Domain Containing 1 2 3 5
  • Serine/Threonine Kinase-Like Domain-Containing Protein 1 3 4
  • Sugen Kinase 071 3 4
  • C9orf96 3 4
  • SgK071 3 4
  • Serine/Threonine Kinase-Like Domain-Containing Protein STKLD1 3
  • Probable Inactive Protein Kinase-Like Protein SgK071 3
  • Chromosome 9 Open Reading Frame 96 2
  • Sk521 3

External Ids for STKLD1 Gene

Previous HGNC Symbols for STKLD1 Gene

  • C9orf96

Summaries for STKLD1 Gene

GeneCards Summary for STKLD1 Gene

STKLD1 (Serine/Threonine Kinase Like Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

Additional gene information for STKLD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STKLD1 Gene

Genomics for STKLD1 Gene

GeneHancer (GH) Regulatory Elements for STKLD1 Gene

Promoters and enhancers for STKLD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I133373 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.9 -895 3.1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF207 ZNF143 FOS DEK SP3 STKLD1 SURF4 SURF6 SURF1 LOC100130548 WDR5 GTF3C5 ADAMTS13 PIR60170
GH09I133029 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.4 -345.7 -345660 2.5 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 GTF3C5 LOC105376306 SETX TTF1 MED22 DDX31 TSC1 GTF3C4 BRD3OS SPACA9
GH09I134134 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.5 +759.7 759721 4 CLOCK ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF213 ZNF207 WDR5 ENSG00000273249 STKLD1 SARDH GC09M134165 RNU6ATAC
GH09I133485 Enhancer 1.1 Ensembl ENCODE 11.1 +110.1 110068 1.1 RB1 ARID4B SIN3A ZNF2 ZNF48 RAD21 ZEB1 ARID2 ZNF143 RCOR1 CACFD1 ADAMTS13 REXO4 ENSG00000201451 ENSG00000230064 SURF6 SURF4 STKLD1 MYMK ADAMTSL2
GH09I133280 Enhancer 0.6 ENCODE 10.4 -95.9 -95864 0.2 GATAD2A SMARCE1 HDAC1 PKNOX1 ZNF407 DPF2 ZEB2 ZNF766 CTBP1 SMARCA4 ENSG00000201451 ENSG00000230064 SURF6 STKLD1 SURF4 SURF1 ABO PIR42730
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STKLD1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for STKLD1 Gene

Genomic Locations for STKLD1 Gene
chr9:133,376,367-133,406,096
(GRCh38/hg38)
Size:
29,730 bases
Orientation:
Plus strand
chr9:136,243,117-136,271,220
(GRCh37/hg19)

Genomic View for STKLD1 Gene

Genes around STKLD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STKLD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STKLD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STKLD1 Gene

Proteins for STKLD1 Gene

  • Protein details for STKLD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE28-STKL1_HUMAN
    Recommended name:
    Serine/threonine kinase-like domain-containing protein STKLD1
    Protein Accession:
    Q8NE28
    Secondary Accessions:
    • Q5T8U8
    • Q6ZMP6
    • Q6ZMQ5

    Protein attributes for STKLD1 Gene

    Size:
    680 amino acids
    Molecular mass:
    75676 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STKLD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STKLD1 Gene

Post-translational modifications for STKLD1 Gene

No Post-translational modifications

Other Protein References for STKLD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for STKLD1
  • Santa Cruz Biotechnology (SCBT) Antibodies for STKLD1

No data available for DME Specific Peptides for STKLD1 Gene

Domains & Families for STKLD1 Gene

Gene Families for STKLD1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for STKLD1 Gene

Suggested Antigen Peptide Sequences for STKLD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NE28

UniProtKB/Swiss-Prot:

STKL1_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
genes like me logo Genes that share domains with STKLD1: view

Function for STKLD1 Gene

Phenotypes From GWAS Catalog for STKLD1 Gene

Gene Ontology (GO) - Molecular Function for STKLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with STKLD1: view
genes like me logo Genes that share phenotypes with STKLD1: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STKLD1 Gene

Localization for STKLD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STKLD1 gene
Compartment Confidence
nucleus 2
plasma membrane 1
peroxisome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for STKLD1 Gene

Pathways & Interactions for STKLD1 Gene

SuperPathways for STKLD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STKLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with STKLD1: view

No data available for Pathways by source and SIGNOR curated interactions for STKLD1 Gene

Drugs & Compounds for STKLD1 Gene

No Compound Related Data Available

Transcripts for STKLD1 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for STKLD1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - -
SP2:
SP3: - - - - -
SP4:

Relevant External Links for STKLD1 Gene

GeneLoc Exon Structure for
STKLD1
ECgene alternative splicing isoforms for
STKLD1

Expression for STKLD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STKLD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of STKLD1 Gene:

STKLD1

Evidence on tissue expression from TISSUES for STKLD1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with STKLD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STKLD1 Gene

Orthologs for STKLD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STKLD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC746554 33
  • 99.04 (n)
C9orf96 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H9orf96 33
  • 80.45 (n)
C9orf96 34
  • 69 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C11H9orf96 33
  • 77.33 (n)
C9orf96 34
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm711 33 34
  • 72.94 (n)
Stkld1 16
rat
(Rattus norvegicus)
Mammalia RGD1307355 33
  • 70.79 (n)
oppossum
(Monodelphis domestica)
Mammalia C9orf96 34
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf96 34
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17H9ORF96 33
  • 51.97 (n)
C9orf96 34
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 31 (a)
OneToMany
-- 34
  • 29 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491915 33
  • 49.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2639 34
  • 22 (a)
OneToOne
Species where no ortholog for STKLD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for STKLD1 Gene

ENSEMBL:
Gene Tree for STKLD1 (if available)
TreeFam:
Gene Tree for STKLD1 (if available)

Paralogs for STKLD1 Gene

No data available for Paralogs for STKLD1 Gene

Variants for STKLD1 Gene

Sequence variations from dbSNP and Humsavar for STKLD1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
VAR_041371 A glioblastoma multiforme sample p.Gly139Asp
rs1000027809 -- 133,375,527(+) G/A upstream_transcript_variant
rs1000447742 -- 133,398,517(+) G/A intron_variant
rs1000546467 -- 133,399,961(+) C/T intron_variant
rs1000613058 -- 133,398,808(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STKLD1 Gene

Variant ID Type Subtype PubMed ID
dgv4532e59 CNV duplication 20981092
esv2657001 CNV deletion 23128226
esv2739138 CNV deletion 23290073
esv3621940 CNV loss 21293372
nsv1125319 OTHER inversion 24896259
nsv433408 CNV gain 18776910
nsv512995 CNV insertion 21212237
nsv512996 CNV insertion 21212237

Variation tolerance for STKLD1 Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.50; 77.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STKLD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STKLD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STKLD1 Gene

Disorders for STKLD1 Gene

Additional Disease Information for STKLD1

No disorders were found for STKLD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STKLD1 Gene

Publications for STKLD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. The protein kinase complement of the human genome. (PMID: 12471243) Manning G … Sudarsanam S (Science (New York, N.Y.) 2002) 3 4 58

Products for STKLD1 Gene

Sources for STKLD1 Gene

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