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STK40 Gene

protein-coding   GIFtS: 55
GCID: GC01M036805

Serine/Threonine Kinase 40

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Threonine Kinase 401 2     EC 2.7.11.13 8
SHIK2 3 5     Ser/Thr-Like Kinase2
Sugen Kinase 4952 3     Serine/Threonine-Protein Kinase 402
SgK4952 3     SGK4953
SINK-Homologous Serine/Threonine-Protein Kinase2 3     EC 2.7.118

External Ids:    HGNC: 213731   Entrez Gene: 839312   Ensembl: ENSG000001961827   OMIM: 6094375   UniProtKB: Q8N2I93   

Export aliases for STK40 gene to outside databases

Previous GC identifers: GC01M036475 GC01M036577 GC01M034921


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STK40 Gene:
STK40 (serine/threonine kinase 40) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is TRIB3.

UniProtKB/Swiss-Prot: STK40_HUMAN, Q8N2I9
Function: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription

Gene Wiki entry for STK40 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the STK40 gene promoter:
         GR   AML1a   Pax-5   p53   LCR-F1   CREB   AREB6   PPAR-gamma1   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK40 promoter sequence
   Search Chromatin IP Primers for STK40

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK40


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

STK40 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK40 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M036805:  view genomic region     (about GC identifiers)

Start:
36,805,225 bp from pter      End:
36,851,497 bp from pter
Size:
46,273 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: STK40_HUMAN, Q8N2I9 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 40  
Size: 435 amino acids; 49001 Da
Sequence caution: Sequence=AAH08344.1; Type=Erroneous initiation; Sequence=BAB15794.1; Type=Erroneous initiation;
Sequence=BAC11361.1; Type=Erroneous initiation;
Secondary accessions: D3DPS8 Q5VTK8 Q5VTK9 Q6ZMN1 Q8N2J8 Q8N3I6 Q96HN6 Q96I44 Q9BSA3 Q9H7H6
Alternative splicing: 4 isoforms:  Q8N2I9-1   Q8N2I9-2   Q8N2I9-3   Q8N2I9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STK40: NX_Q8N2I9

Explore proteomics data for STK40 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for STK40 (Q8N2I9) (see all 17)
     IIASWQS  RLSERET  IVHRDLK  PPVRRLG 


    See STK40 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269475.1  NP_001269476.1  NP_114406.1  

    ENSEMBL proteins: 
     ENSP00000352245   ENSP00000362221   ENSP00000362222   ENSP00000362224  

    STK40 Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for STK40
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    Cloud-Clone Corp. Proteins for STK40

     
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    antibodies-online proteins for STK40 (9 products) 

     
    antibodies-online peptides for STK40

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine kinase 40
    CAMK-unique family

    5 InterPro protein domains:
     IPR024104 Tribbles/Ser_Thr_kinase_40
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR024236 Ser/Thr_kinase_40
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q8N2I9

    ProtoNet protein and cluster: Q8N2I9

    UniProtKB/Swiss-Prot: STK40_HUMAN, Q8N2I9
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with STK40           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STK40_HUMAN, Q8N2I9
    Function: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with STK40           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for STK40:
     Decreased focal adhesion (FA)   Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Elongated cells 
     Stronger migration 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Stk40):
     cellular  growth/size/body  homeostasis/metabolism  mortality/aging  respiratory system 

    Find genes that share phenotypes with STK40           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for STK40

    miRNA
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    miRTarBase miRNAs that target STK40:
    hsa-mir-183-5p (MIRT047110), hsa-mir-940 (MIRT036586), hsa-mir-615-3p (MIRT039827), hsa-mir-103a-3p (MIRT027005), hsa-mir-196a-5p (MIRT026054), hsa-mir-31-5p (MIRT007319), hsa-let-7d-5p (MIRT032155), hsa-mir-7-5p (MIRT025713), hsa-mir-106b-5p (MIRT044350)

    Block miRNA regulation of human, mouse, rat STK40 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK40 (see all 83):
    hsa-miR-520e hsa-miR-300 hsa-miR-631 hsa-miR-134 hsa-miR-128 hsa-miR-342-3p hsa-miR-10b* hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidSTK40 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STK40

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    Sino Biological Human cDNA Clone for STK40
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK40
    Addgene plasmids for STK40 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK40


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STK40_HUMAN, Q8N2I9: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion2
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with STK40           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STK40
    Interactions:

        Search GeneGlobe Interaction Network for STK40

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for STK40 (Q8N2I92, 3 ENSP000003622214) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS6Q7L5N12, 3MINT-65191 I2D: score=5 
    POLA2Q141812, 3MINT-65192 I2D: score=5 
    FYCO1Q9BQS83I2D: score=1 
    RCN2ENSP000003783494STRING: ENSP00000378349
    RPTORENSP000003072724STRING: ENSP00000307272
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with STK40           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STK40



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STK40 gene (3 alternative transcripts): 
    NM_001282546.1  NM_001282547.1  NM_032017.2  

    Unigene Cluster for STK40:

    Serine/threonine kinase 40
    Hs.471768  [show with all ESTs]
    Unigene Representative Sequence: AK024504
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359297(uc001can.1) ENST00000373129(uc001cak.1) ENST00000373130(uc001cal.1)
    ENST00000373132(uc001cam.1) ENST00000460417 ENST00000473733 ENST00000482458
    ENST00000460017
    miRNA
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    Block miRNA regulation of human, mouse, rat STK40 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK40 (see all 83):
    hsa-miR-520e hsa-miR-300 hsa-miR-631 hsa-miR-134 hsa-miR-128 hsa-miR-342-3p hsa-miR-10b* hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidSTK40 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STK40
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK40
    Addgene plasmids for STK40 
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    OriGene qPCR primer pairs and template standards for STK40
    OriGene qSTAR qPCR primer pairs in human, mouse for STK40
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STK40
      QuantiTect SYBR Green Assays in human, mouse, rat STK40
      QuantiFast Probe-based Assays in human, mouse, rat STK40

    Additional mRNA sequence: 

    AK000808.1 AK023810.1 AK024504.1 AK075029.1 AK075048.1 AK131560.1 AL834137.1 AY198395.1 
    BC005169.2 BC007835.2 BC008344.1 

    Selected DOTS entries (see all 27):

    DT.65287345  DT.95343608  DT.121344163  DT.100796260  DT.121344144  DT.100724757  DT.121344070  DT.121344095 
    DT.121343994  DT.121344096  DT.121344097  DT.91692215  DT.95343606  DT.121344072  DT.121344083  DT.121344167 
    DT.97773456  DT.99949522  DT.99961525  DT.100796257  DT.100796258  DT.40123908  DT.91848704  DT.92014922 

    Selected AceView cDNA sequences (see all 383):

    CB961676 BM851889 BM848722 BU784532 BM851935 R62973 BM851891 AA343618 
    BM848706 BM849109 BM820568 BM849071 AY198395 BM848743 BU607419 BM820872 
    BM912914 BQ083152 AL834137 AI423569 BM469837 BM848682 AA741461 AI138316 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STK40 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13a · 13b ^ 14a · 14b ^ 15a ·
    SP1:              -     -     -     -     -     -     -                                                                             -           -               
    SP2:              -     -     -     -     -     -     -                 -                                                           -           -               
    SP3:                                                                    -                                                           -           -               
    SP4:              -     -     -     -           -     -                                                                                                         
    SP5:                                -           -     -                 -                                                                                       

    ExUns: 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b
    SP1:        -                                 
    SP2:        -                                 
    SP3:        -                                 
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for STK40

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STK40 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGCAATAA
    STK40 Expression
    About this image


    STK40 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SM30, NCr-fac & Meso-latp Progenitor
     
     Epidermis (Integumentary System)
             Stratified Epidermis
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             PureStem SM30, NCr-fac & Meso-latp Progenitor
     
     Stomach (Gastrointestinal Tract)
    STK40 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STK40 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.471768

    UniProtKB/Swiss-Prot: STK40_HUMAN, Q8N2I9
    Tissue specificity: Strongly expressed in heart, brain, placenta, lung, skeletal muscle, kidney, spleen, thymus,
    prostate, liver, pancreas, testis, ovary, small intestine, colon and peripheral blood leukocytes

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    QuantiFast Probe-based Assays in human, mouse, rat STK40
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK40

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STK40 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk401 , 5 serine/threonine kinase 401, 5 89.81(n)1
    97.24(a)1
      4 (59.89 cM)5
    741781  NM_001145827.11  NP_001139299.11 
     1261039725 
    chicken
    (Gallus gallus)
    Aves STK401 serine/threonine kinase 40 81.69(n)
    89.89(a)
      395120  NM_204466.1  NP_989797.1 
    lizard
    (Anolis carolinensis)
    Reptilia STK406
    serine/threonine kinase 40
    86(a)
    1 ↔ 1
    GL343610.1(336769-354952)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986812 Ser/Thr-like protein kinase lyk4 75.98(n)    AY336058.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stk401 serine/threonine kinase 40 76.45(n)
    85.05(a)
      564859  XM_688183.6  XP_693275.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta trbl6
    tribbles
    18(a)
    1 → many
    3L(20389388-20394709)
    worm
    (Caenorhabditis elegans)
    Secernentea nipi-36
    Protein NIPI-3 (nipi-3) mRNA, complete cds
    9(a)
    1 → many
    X(15607969-15611811) WBGene00010700


    ENSEMBL Gene Tree for STK40 (if available)
    TreeFam Gene Tree for STK40 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STK40 gene
    TRIB32  NUAK12  PRKAA22  HUNK2  TRIB12  NUAK22  PRKAA12  TRIB22  
    MELK2  

    Find genes that share paralogs with STK40           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STK40 (see all 957)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0412024
    A colorectal adenocarcinoma sample4--see VAR_0412022 R Q mis40--------
    VAR_0412014
    A colorectal adenocarcinoma sample4--see VAR_0412012 M T mis40--------
    rs1882247031,2
    --36804798(+) CCTTCC/TCTGGC 1 -- int10--------
    rs1925573851,2
    --36804853(+) CCCCTA/GCCCCA 1 -- int10--------
    rs351351511,2
    C,F--36804959(+) CCAAGC/GAGGGA 1 -- int13Minor allele frequency- G:0.33NA 6
    rs46531801,2
    C--36805024(+) TCAGGG/TTCCCC 1 -- int10--------
    rs729015191,2
    C,F--36805048(+) CAGTGG/ATGCCA 1 -- int13Minor allele frequency- A:0.14WA CSA 122
    rs11286651,2
    C,F,H--36805312(-) AAGTCA/CCAAAA 1 -- ut31 ese35Minor allele frequency- C:0.02MN EA NS NA 480
    rs1128770191,2
    C,F--36805443(+) CCCAGG/TCTGTC 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1848919381,2
    --36805637(+) TTTCCA/GCTCCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for STK40 (36805225 - 36851497 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for STK40:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676376CNV Deletion23128226
    nsv524394CNV Loss19592680
    nsv834702CNV Loss17160897
    dgv47e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STK40
    DNA2.0 Custom Variant and Variant Library Synthesis for STK40

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609437    OMIM disorders: --


    Find genes that share disorders with STK40           About GenesLikeMe

    Genetic Association Database (GAD): STK40
    Human Genome Epidemiology (HuGE) Navigator: STK40 (1 document)

    Export disorders for STK40 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STK40 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with STK40)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel serine/threonine kinase that inhibits TNF- induced NF-kappaB activation and p53-induced transcription. (PubMed id 13679039)1, 2, 9 Huang J....Shu H.-B. (Biochem. Biophys. Res. Commun. 2003)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. MicroRNA-31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting serine/threonine kinase 40. (PubMed id 23233723)1 Xu N....Sonkoly E. (J. Immunol. 2013)
    6. Identification of biomarkers of human skin ageing in both genders. Wnt signalling - a label of skin ageing? (PubMed id 23226273)1 Makrantonaki E....Zouboulis C.C. (PLoS ONE 2012)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    9. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (Mol. Syst. Biol. 2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83931 HGNC: 21373 AceView: MGC4796 Ensembl:ENSG00000196182 euGenes: HUgn83931
    ECgene: STK40 H-InvDB: STK40

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STK40 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STK40 gene:
    Search GeneIP for patents involving STK40

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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