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Aliases for STK40 Gene

Aliases for STK40 Gene

  • Serine/Threonine Kinase 40 2 3 5
  • SINK-Homologous Serine/Threonine-Protein Kinase 3 4
  • Sugen Kinase 495 3 4
  • EC 2.7.11.1 4 63
  • SgK495 3 4
  • SHIK 3 4
  • Ser/Thr-Like Kinase 3
  • EC 2.7.11 63

External Ids for STK40 Gene

Previous GeneCards Identifiers for STK40 Gene

  • GC01M036475
  • GC01M036577
  • GC01M036805
  • GC01M034921

Summaries for STK40 Gene

GeneCards Summary for STK40 Gene

STK40 (Serine/Threonine Kinase 40) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TRIB2.

UniProtKB/Swiss-Prot for STK40 Gene

  • May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.

Gene Wiki entry for STK40 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK40 Gene

Genomics for STK40 Gene

Regulatory Elements for STK40 Gene

Enhancers for STK40 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STK40 on UCSC Golden Path with GeneCards custom track

Promoters for STK40 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STK40 on UCSC Golden Path with GeneCards custom track

Genomic Location for STK40 Gene

Chromosome:
1
Start:
36,339,619 bp from pter
End:
36,385,927 bp from pter
Size:
46,309 bases
Orientation:
Minus strand

Genomic View for STK40 Gene

Genes around STK40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK40 Gene

Proteins for STK40 Gene

  • Protein details for STK40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2I9-STK40_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 40
    Protein Accession:
    Q8N2I9
    Secondary Accessions:
    • D3DPS8
    • Q5VTK8
    • Q5VTK9
    • Q6ZMN1
    • Q8N2J8
    • Q8N3I6
    • Q96HN6
    • Q96I44
    • Q9BSA3
    • Q9H7H6

    Protein attributes for STK40 Gene

    Size:
    435 amino acids
    Molecular mass:
    49001 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH08344.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15794.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11361.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STK40 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK40 Gene

Proteomics data for STK40 Gene at MOPED

Post-translational modifications for STK40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STK40 Gene

Domains & Families for STK40 Gene

Gene Families for STK40 Gene

Suggested Antigen Peptide Sequences for STK40 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N2I9

UniProtKB/Swiss-Prot:

STK40_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK40: view

Function for STK40 Gene

Molecular function for STK40 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.

Enzyme Numbers (IUBMB) for STK40 Gene

Gene Ontology (GO) - Molecular Function for STK40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with STK40: view
genes like me logo Genes that share phenotypes with STK40: view

Animal Models for STK40 Gene

MGI Knock Outs for STK40:

Animal Model Products

  • Taconic Biosciences Mouse Models for STK40

miRNA for STK40 Gene

miRTarBase miRNAs that target STK40

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK40 Gene

Localization for STK40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK40 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK40 Gene COMPARTMENTS Subcellular localization image for STK40 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for STK40 Gene

Pathways & Interactions for STK40 Gene

SuperPathways for STK40 Gene

No Data Available

Interacting Proteins for STK40 Gene

Gene Ontology (GO) - Biological Process for STK40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003016 respiratory system process IEA --
GO:0005977 glycogen metabolic process IEA --
GO:0006468 protein phosphorylation IEA --
GO:0010468 regulation of gene expression IEA --
GO:0030324 lung development IEA --
genes like me logo Genes that share ontologies with STK40: view

No data available for Pathways by source and SIGNOR curated interactions for STK40 Gene

Drugs & Compounds for STK40 Gene

No Compound Related Data Available

Transcripts for STK40 Gene

Unigene Clusters for STK40 Gene

Serine/threonine kinase 40:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK40 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: - -
SP7: -
SP8: - - - - - - -
SP9: - - - - -
SP10: -
SP11:
SP12:
SP13: - - - - - - - - -
SP14:
SP15:

ExUns: 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15:

Relevant External Links for STK40 Gene

GeneLoc Exon Structure for
STK40
ECgene alternative splicing isoforms for
STK40

Expression for STK40 Gene

mRNA expression in normal human tissues for STK40 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK40 Gene

This gene is overexpressed in Whole Blood (x6.2).

Protein differential expression in normal tissues from HIPED for STK40 Gene

This gene is overexpressed in Monocytes (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STK40 Gene



SOURCE GeneReport for Unigene cluster for STK40 Gene Hs.471768

mRNA Expression by UniProt/SwissProt for STK40 Gene

Q8N2I9-STK40_HUMAN
Tissue specificity: Strongly expressed in heart, brain, placenta, lung, skeletal muscle, kidney, spleen, thymus, prostate, liver, pancreas, testis, ovary, small intestine, colon and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with STK40: view

Protein tissue co-expression partners for STK40 Gene

Primer Products

Orthologs for STK40 Gene

This gene was present in the common ancestor of animals.

Orthologs for STK40 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STK40 35
  • 91.19 (n)
  • 96.55 (a)
STK40 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK40 35
  • 91.03 (n)
  • 97.7 (a)
STK40 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk40 35
  • 89.81 (n)
  • 97.24 (a)
Stk40 16
Stk40 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STK40 35
  • 99.16 (n)
  • 99.49 (a)
STK40 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk40 35
  • 89.5 (n)
  • 97.24 (a)
oppossum
(Monodelphis domestica)
Mammalia STK40 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK40 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK40 35
  • 81.69 (n)
  • 89.89 (a)
STK40 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK40 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk40 35
  • 75.08 (n)
  • 86.81 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398681 35
zebrafish
(Danio rerio)
Actinopterygii stk40 35
  • 76.45 (n)
  • 85.05 (a)
STK40 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008948 35
  • 56.81 (n)
  • 51.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta trbl 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nipi-3 36
  • 9 (a)
OneToMany
Species with no ortholog for STK40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK40 Gene

ENSEMBL:
Gene Tree for STK40 (if available)
TreeFam:
Gene Tree for STK40 (if available)

Paralogs for STK40 Gene

Paralogs for STK40 Gene

genes like me logo Genes that share paralogs with STK40: view

Variants for STK40 Gene

Sequence variations from dbSNP and Humsavar for STK40 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs56314546 - 36,361,304(+) CCCCA(A/G)CTCCT reference, missense
VAR_041201 A colorectal adenocarcinoma sample
VAR_041202 A colorectal adenocarcinoma sample
rs3795498 - 36,341,880(-) ATGAC(A/G)CCCGG reference, missense
rs1128665 -- 36,339,711(+) AAGTC(A/C/G/T)CAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for STK40 Gene

Variant ID Type Subtype PubMed ID
dgv47e1 CNV Complex 17122850
nsv834702 CNV Loss 17160897
nsv524394 CNV Loss 19592680
esv2676376 CNV Deletion 23128226

Variation tolerance for STK40 Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.95; 83.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STK40 Gene

Disorders for STK40 Gene

Relevant External Links for STK40

Genetic Association Database (GAD)
STK40
Human Genome Epidemiology (HuGE) Navigator
STK40
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK40

No disorders were found for STK40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK40 Gene

Publications for STK40 Gene

  1. Identification of a novel serine/threonine kinase that inhibits TNF- induced NF-kappaB activation and p53-induced transcription. (PMID: 13679039) Huang J. … Shu H.-B. (Biochem. Biophys. Res. Commun. 2003) 3 4 23 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for STK40 Gene

Sources for STK40 Gene

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