Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STK40 Gene

protein-coding   GIFtS: 54
GCID: GC01M036805

Serine/Threonine Kinase 40

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine/Threonine Kinase 401 2     EC 2.7.11.13 8
SHIK2 3 5     Ser/Thr-Like Kinase2
Sugen Kinase 4952 3     Serine/Threonine-Protein Kinase 402
SgK4952 3     SGK4953
SINK-Homologous Serine/Threonine-Protein Kinase2 3     EC 2.7.118

External Ids:    HGNC: 213731   Entrez Gene: 839312   Ensembl: ENSG000001961827   OMIM: 6094375   UniProtKB: Q8N2I93   

Export aliases for STK40 gene to outside databases

Previous GC identifers: GC01M036475 GC01M036577 GC01M034921


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for STK40 Gene: 
STK40 (serine/threonine kinase 40) is a protein-coding gene. Diseases associated with STK40 include prostatitis. GO annotations related to this gene include protein serine/threonine kinase activity and ATP binding. An important paralog of this gene is BRSK1.

UniProtKB/Swiss-Prot: STK40_HUMAN, Q8N2I9
Function: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription

Gene Wiki entry for STK40 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STK40 gene promoter:
         GR   AML1a   Pax-5   p53   LCR-F1   CREB   AREB6   PPAR-gamma1   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK40 promoter sequence
   Search SABiosciences Chromatin IP Primers for STK40

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK40


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

STK40 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK40 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M036805:  view genomic region     (about GC identifiers)

Start:
36,805,225 bp from pter      End:
36,851,497 bp from pter
Size:
46,273 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STK40_HUMAN, Q8N2I9 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 40  
Size: 435 amino acids; 49001 Da
Subcellular location: Nucleus. Cytoplasm
Sequence caution: Sequence=AAH08344.1; Type=Erroneous initiation; Sequence=BAB15794.1; Type=Erroneous initiation;
Sequence=BAC11361.1; Type=Erroneous initiation;
Secondary accessions: D3DPS8 Q5VTK8 Q5VTK9 Q6ZMN1 Q8N2J8 Q8N3I6 Q96HN6 Q96I44 Q9BSA3 Q9H7H6
Alternative splicing: 4 isoforms:  Q8N2I9-1   Q8N2I9-2   Q8N2I9-3   Q8N2I9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STK40: NX_Q8N2I9

Explore proteomics data for STK40 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N2I9

  • 4/17 DME Specific Peptides for STK40 (Q8N2I9) (see all 17)
     IIASWQS  RLSERET  IVHRDLK  PPVRRLG 

    STK40 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STK40 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001269475.1  NP_001269476.1  NP_114406.1  

    ENSEMBL proteins: 
     ENSP00000352245   ENSP00000362221   ENSP00000362222   ENSP00000362224  

    Human Recombinant Protein Products for STK40: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for STK40
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for STK40
    GenScript Custom Purified and Recombinant Proteins Services for STK40
    Novus Biologicals STK40 Proteins
    Novus Biologicals STK40 Lysates
    Sino Biological Recombinant Protein for STK40
    Sino Biological Cell Lysate for STK40 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STK40 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    STK40 for ontologies           About GeneDecksing



    STK40 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for STK40
    OriGene Custom Antibody Services for STK40
    GenScript Custom Superior Antibodies Services for STK40
    Novus Biologicals STK40 Antibodies
    Abcam antibodies for STK40
    Cloud-Clone Corp. Antibodies for STK40 
    ThermoFisher Antibody for STK40
    LSBio Antibodies in human, mouse, rat for STK40 

    Assay Products for STK40: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STK40
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STK40
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STK40 
    Cloud-Clone Corp. CLIAs for STK40


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine kinase 40 
    CAMK-unique family

    5 InterPro protein domains:
     IPR024104 Tribbles/Ser_Thr_kinase_40
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR024236 Ser/Thr_kinase_40
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8N2I9

    ProtoNet protein and cluster: Q8N2I9

    UniProtKB/Swiss-Prot: STK40_HUMAN, Q8N2I9
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    STK40 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STK40_HUMAN, Q8N2I9
    Function: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    STK40 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for STK40:
     Decreased focal adhesion (FA)   Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Elongated cells 
     Stronger migration 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Stk40):
     cellular  growth/size  homeostasis/metabolism  mortality/aging  respiratory system 

    STK40 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for STK40 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STK40

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STK40 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STK40 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STK40
    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate STK40 (see all 83):
    hsa-miR-520e hsa-miR-300 hsa-miR-631 hsa-miR-134 hsa-miR-128 hsa-miR-342-3p hsa-miR-10b* hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidSTK40 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STK40
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STK40

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STK40
    Sirion Biotech Customized adenovirus for overexpression of STK40

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for STK40 (see all 8)
    OriGene ORF clones in mouse, rat for STK40
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STK40 (NM_032017)
    Sino Biological Human cDNA Clone for STK40
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STK40
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK40
    Sirion Biotech Customized lentivirus for stable overexpression of STK40 
                         Customized lentivirus expression plasmids for stable overexpression of STK40 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STK40
    Search LifeMap BioReagents cell lines for STK40
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK40


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STK40

    3 Interacting proteins for STK40 (Q8N2I92, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS6Q7L5N12, 3MINT-65191 I2D: score=5 
    POLA2Q141812, 3MINT-65192 I2D: score=5 
    FYCO1Q9BQS83I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    STK40 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STK40

    Search CenterWatch for drugs/clinical trials and news about STK40

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STK40 gene (3 alternative transcripts): 
    NM_001282546.1  NM_001282547.1  NM_032017.2  

    Unigene Cluster for STK40:

    Serine/threonine kinase 40
    Hs.471768  [show with all ESTs]
    Unigene Representative Sequence: AK024504
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359297(uc001can.1) ENST00000373129(uc001cak.1) ENST00000373130(uc001cal.1)
    ENST00000373132(uc001cam.1) ENST00000460417 ENST00000473733 ENST00000482458
    ENST00000460017
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STK40
    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate STK40 (see all 83):
    hsa-miR-520e hsa-miR-300 hsa-miR-631 hsa-miR-134 hsa-miR-128 hsa-miR-342-3p hsa-miR-10b* hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidSTK40 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STK40
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STK40
    Clone
    Products:
         
    OriGene clones in human, mouse for STK40 (see all 8)
    OriGene ORF clones in mouse, rat for STK40
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STK40 (NM_032017)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STK40
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK40
    Sirion Biotech Customized lentivirus for stable overexpression of STK40 
                         Customized lentivirus expression plasmids for stable overexpression of STK40 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STK40
    OriGene qSTAR qPCR primer pairs in human, mouse for STK40
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STK40
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STK40
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STK40

    Additional mRNA sequence: 

    AK000808.1 AK023810.1 AK024504.1 AK075029.1 AK075048.1 AK131560.1 AL834137.1 AY198395.1 
    BC005169.2 BC007835.2 BC008344.1 

    24/27 DOTS entries (see all 27):

    DT.65287345  DT.95343608  DT.121344163  DT.100796260  DT.121344144  DT.100724757  DT.121344070  DT.121344095 
    DT.121343994  DT.121344096  DT.121344097  DT.91692215  DT.95343606  DT.121344072  DT.121344083  DT.121344167 
    DT.97773456  DT.99949522  DT.99961525  DT.100796257  DT.100796258  DT.40123908  DT.91848704  DT.92014922 

    24/383 AceView cDNA sequences (see all 383):

    BM849037 BQ186122 AW083112 AA741461 AA758768 AA814531 BQ643074 BC007835 
    CA392070 BM810227 BI829732 AI859290 AL834137 BM820872 BG577173 BC005169 
    BM848743 AI950264 BQ229484 BM851944 BM818821 BQ059730 AK075029 BU845842 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for STK40 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13a · 13b ^ 14a · 14b ^ 15a ·
    SP1:              -     -     -     -     -     -     -                                                                             -           -               
    SP2:              -     -     -     -     -     -     -                 -                                                           -           -               
    SP3:                                                                    -                                                           -           -               
    SP4:              -     -     -     -           -     -                                                                                                         
    SP5:                                -           -     -                 -                                                                                       

    ExUns: 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b
    SP1:        -                                 
    SP2:        -                                 
    SP3:        -                                 
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for STK40

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STK40 expression in normal human tissues (normalized intensities)      STK40 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGCAATAA
    STK40 Expression
    About this image


    STK40 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SM30, NCr-fac & Meso-latp Progenitor
     
     Testis (Reproductive System)
             sperm   
     
     Epidermis (Integumentary System)
             Stratified Epidermis
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             PureStem SM30, NCr-fac & Meso-latp Progenitor

    See STK40 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STK40

    SOURCE GeneReport for Unigene cluster: Hs.471768

    UniProtKB/Swiss-Prot: STK40_HUMAN, Q8N2I9
    Tissue specificity: Strongly expressed in heart, brain, placenta, lung, skeletal muscle, kidney, spleen, thymus,
    prostate, liver, pancreas, testis, ovary, small intestine, colon and peripheral blood leukocytes

        SABiosciences Custom PCR Arrays for STK40
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for STK40
    OriGene qSTAR qPCR primer pairs in human, mouse for STK40
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STK40
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STK40
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STK40
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK40

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for STK40 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk401 , 5 serine/threonine kinase 401, 5 89.81(n)1
    97.24(a)1
      4 (59.89 cM)5
    741781  NM_001145827.11  NP_001139299.11 
     1261039725 
    chicken
    (Gallus gallus)
    Aves STK401 serine/threonine kinase 40 81.69(n)
    89.89(a)
      395120  NM_204466.1  NP_989797.1 
    lizard
    (Anolis carolinensis)
    Reptilia STK406
    Uncharacterized protein
    86(a)
    1 ↔ 1
    GL343610.1(336769-354952)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986812 Ser/Thr-like protein kinase lyk4 75.98(n)    AY336058.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stk401 serine/threonine kinase 40 76.45(n)
    85.05(a)
      564859  XM_688183.5  XP_693275.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta trbl6
    tribbles
    15(a)
    1 → many
    3L(20389388-20394709)
    worm
    (Caenorhabditis elegans)
    Secernentea nipi-36
    Protein NIPI-3
    8(a)
    1 → many
    X(15607969-15610631)


    ENSEMBL Gene Tree for STK40 (if available)
    TreeFam Gene Tree for STK40 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STK40 gene
    BRSK12  TRIB32  TRIB22  BRSK22  TRIB12  

    STK40 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/957 SNPs in STK40 are shown (see all 957)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0412024
    A colorectal adenocarcinoma sample4--see VAR_0412022 R Q mis40--------
    VAR_0412014
    A colorectal adenocarcinoma sample4--see VAR_0412012 M T mis40--------
    rs1882247031,2
    --36804798(+) CCTTCC/TCTGGC 1 -- int10--------
    rs1925573851,2
    --36804853(+) CCCCTA/GCCCCA 1 -- int10--------
    rs351351511,2
    C,F--36804959(+) CCAAGC/GAGGGA 1 -- int13Minor allele frequency- G:0.33NA 6
    rs46531801,2
    C--36805024(+) TCAGGG/TTCCCC 1 -- int10--------
    rs729015191,2
    C,F--36805048(+) CAGTGG/ATGCCA 1 -- int13Minor allele frequency- A:0.14WA CSA 122
    rs11286651,2
    C,F,H--36805312(-) AAGTCA/CCAAAA 1 -- ut31 ese35Minor allele frequency- C:0.02MN EA NS NA 480
    rs1128770191,2
    C,F--36805443(+) CCCAGG/TCTGTC 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1848919381,2
    --36805637(+) TTTCCA/GCTCCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for STK40 (36805225 - 36851497 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for STK40:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676376CNV Deletion23128226
    nsv524394CNV Loss19592680
    nsv834702CNV Loss17160897
    dgv47e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing STK40
    DNA2.0 Custom Variant and Variant Library Synthesis for STK40

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609437    OMIM disorders: --

    2 diseases for STK40:    About MalaCards
    prostatitis    


    STK40 for disorders           About GeneDecksing

    Genetic Association Database (GAD): STK40
    Human Genome Epidemiology (HuGE) Navigator: STK40 (1 document)

    Export disorders for STK40 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STK40 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with STK40)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel serine/threonine kinase that inhibits TNF- induced NF-kappaB activation and p53-induced transcription. (PubMed id 13679039)1, 2, 9 Huang J....Shu H.-B. (2003)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. MicroRNA-31 is overexpressed in psoriasis and modulate s inflammatory cytokine and chemokine production in keratinocytes via targeting serine/threonine kinase 40. (PubMed id 23233723)1 Xu N....Sonkoly E. (2013)
    6. Identification of biomarkers of human skin ageing in b oth genders. Wnt signalling - a label of skin ageing? (PubMed id 23226273)1 Makrantonaki E....Zouboulis C.C. (2012)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    9. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83931 HGNC: 21373 AceView: MGC4796 Ensembl:ENSG00000196182 euGenes: HUgn83931
    ECgene: STK40 H-InvDB: STK40

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STK40 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STK40 gene:
    Search GeneIP for patents involving STK40

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for STK40   OriGene RNAi products in human, mouse, rat for STK40  
     OriGene qPCR primer pairs and template standards for STK40   OriGene Protein Over-expression Lysate for STK40  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for STK40  
     OriGene qSTAR qPCR primer pairs in human, mouse for STK40   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for STK40   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for STK40   OriGene Custom Protein Services for STK40  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STK40
     QIAGEN SeqTarget long-range PCR primers for resequencing STK40
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK40
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STK40
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STK40
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STK40
     GenScript Custom Purified and Recombinant Proteins Services for STK40 GenScript cDNA clones with any tag delivered in your preferred vector for STK40
     GenScript Custom Assay Services for STK40 GenScript Custom Superior Antibodies Services for STK40
     GenScript Custom overexpressing Cell Line Services for STK40 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in STK40 promoter
     Search Chromatin IP Primers for STK40
     RT2 qPCR Primer Assay in human, mouse, rat STK40
     Search GNC Networks for STK40
     SABiosciences Custom PCR Arrays for STK40
     Search Tocris compounds for STK40
     Proteins and Antibodies for STK40
     Cell Lysates for STK40
     cDNA Clones for STK40
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     STK40 antibodies
     STK40 proteins
     STK40 lysates
     Antibodies for STK40
     See all of Abcam's Antibodies, Kits and Proteins for STK40
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for STK40
     Antibodies for STK40
     ELISAs for STK40
     CLIAs for STK40
     Search LifeMap BioReagents cell lines for STK40
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK40
     SwitchGear 3'UTR luciferase reporter plasmids for STK40
     SwitchGear Promoter luciferase reporter plasmids for STK40
     ThermoFisher Antibody for STK40
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK40
     inGenious Targeting Laboratory - Custom generated mouse model solutions for STK40
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STK40
    Customized:
     lentivirus for stable overexpression of STK40
     lentivirus expression plasmids for stable overexpression of STK40
     adenovirus for overexpression of STK40
     LSBio Antibodies in human, mouse, rat for STK40
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      STK40 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4