STK4 Gene
protein-coding GIFtS: 69
GCID: GC20P043595
|
|
serine/threonine kinase 4
| |
Aliases
for STK4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine/Threonine Kinase 41 2 | | EC 2.7.11.13 8 | | KRS21 2 3 5 | | TIIAC2 | | MST11 2 3 5 | | DJ211D12.2 (Serine/Threonine Kinase 4 (MST1, KRS2))2 | | YSK31 2 | | Kinase Responsive To Stress 22 | | Mammalian STE20-Like Protein Kinase 12 3 | | Mammalian Sterile 20-Like 12 | | Serine/Threonine-Protein Kinase Krs-22 3 | | Serine/Threonine-Protein Kinase 42 | | MST-12 3 | | EC 2.7.118 | | STE20-Like Kinase MST12 3 | | |
Export aliases for STK4 gene to outside databasesPrevious GC identifers: GC20P043323 GC20P044233 GC20P044280 GC20P043028 GC20P040336 |
Summaries
for STK4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for STK4:
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, whichacts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylatemyelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has beenshown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has beencorrelated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in thisprocess. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: STK4_HUMAN, Q13043Function: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induceschromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathwaywhich plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promotingapoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex withits regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, whichin turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits itstranslocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cellmigration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activationof facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in itsnuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3(cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner.Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependenttranscription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' andsuppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes
Gene Wiki entry for STK4
|
Genomic Views
for STK4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STK4 gene promoter:
AML1a Pbx1a Ik-3 NF-AT GATA-1 S8 NF-AT4 NF-AT2 NF-AT3 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for STK4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.2-q13.2 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q11.2-q13.2STK4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P043595: view genomic region
(about GC identifiers)
Start:
|
43,595,115 bp from pter |
End:
|
43,708,600 bp from pter |
Size:
|
113,486 bases |
Orientation:
|
plus strand |
|
Proteins
for STK4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STK4_HUMAN, Q13043 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase 4 Size: 487 amino acids; 55630 Da
Cofactor: Magnesium
Subunit: Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interactswith and stabilizes SAV1. Interacts with RASSF1. Interacts with FOXO3. Interacts with RASSF2 (via SARAH domain).Interacts with AR, PKB/AKT1, TNNI3 and SIRT1
Subcellular location: Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm
Sequence caution: Sequence=AAH29511.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=AAH58916.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
2 PDB 3D structures from  and Proteopedia  for STK4:2JO8 (3D)
3COM (3D)
Secondary accessions: B2RCR8 Q15802 Q4G156 Q5H982 Q6PD60 Q9BR32 Q9NTZ4Alternative splicing: 2 isoforms: Q13043-1 Q13043-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for STK4: NX_Q13043
Post-translational modifications:
Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-120 and Thr-387 by PKB/AKT1, leads toinhibition of its: kinase activity, nuclear translocation and autophosphorylation at Thr-183. It also diminishes itscleavage by caspases and its ability to phosphorylate FOXO31
Proteolytically cleaved by caspase-3 during apoptosis at Asp-326 and Asp-349 resulting in a 37 kDa or a 39 kDa subunitrespectively. The 39 kDa subunit is further cleaved into the 37 kDa form. Proteolytic cleavage results in kinaseactivation and nuclear translocation of the truncated form (MST1/N). It is less likely that cleavage at Asp-349 is aprerequisite for activation as this site is not conserved in the murine ortholog1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13043
4/26 DME Specific Peptides for STK4 (Q13043) (see all 26)
STK4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006273.1
ENSEMBL proteins: ENSP00000361892 ENSP00000361887 ENSP00000443514 ENSP00000379957 Reactome Protein details: Q13043
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
STK4 for ontologies About GeneDecksing
STK4 Antibody Products:
Assay Products for STK4: |
Protein
Domains /
Families
for STK4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STK4 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q13043ProtoNet protein and cluster: Q13043 UniProtKB/Swiss-Prot: STK4_HUMAN, Q13043Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamilySimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 SARAH domain |
Function
for STK4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STK4_HUMAN, Q13043Function: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induceschromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathwaywhich plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promotingapoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex withits regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, whichin turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits itstranslocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cellmigration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activationof facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in itsnuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3(cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner.Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependenttranscription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' andsuppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexesCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Inhibited by the C-terminal non-catalytic region. Activated by caspase-cleavage. Full activationalso requires homodimerization and autophosphorylation of Thr-183. Activated by RASSF1 which acts by preventing itsdephosphorylationInduction: Activity increases during mitosis Genatlas biochemistry entry for STK4:serine/threonine kinase 4,65kDa,mainly expressed in pancreas,heart and skeletal muscle,highly homolog to the DM proteinkinase
Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: STK4 (NM_006282) | |  | Sino Biological Human cDNA Clone for STK4 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STK4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK4 |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
STK4 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for STK4:
Animal Models:
Mouse knock-outs for STK4: Stk4tm1Dlim Stk4tm1.1Yy Stk4tm1.1Kina Stk4tm1.2Wtao
15/18 MGI mutant phenotypes (inferred from 8 alleles ) (MGI details for Stk4) (see all 18):
STK4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for STK4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytoskeletal Signaling | | | 2 | Apoptosis and Autophagy | | | 3 | Signaling by Hippo | | | 4 | Pathways in cancer | | | 5 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for STK4
2 
Cell Signaling Technology (CST) Pathways for STK4
2 
Reactome Pathways for STK4
3 
Kegg Pathways (Kegg details for STK4):
STK4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STK4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/245 Interacting proteins for STK4 (Q130431, 2, 3 ENSP000003618924) via UniProtKB, MINT, STRING, and/or I2D (see all 245)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| AKT1 | P317492, 3, ENSP000002702024 | MINT-6175011 MINT-6175193 MINT-6175251 MINT-6175225 MINT-6174722 MINT-6175034 MINT-6175070 MINT-6175132 MINT-6175047 MINT-6175025 MINT-6175115 MINT-6175085 MINT-6175239 I2D:
score=2 STRING: ENSP00000270202 | | RASSF5 | Q8WWW01, 3, ENSP000003474434 | EBI-367376,EBI-367390 I2D:
score=6 STRING: ENSP00000347443 | | GABARAP | O951661, 3 | EBI-367376,EBI-712001 I2D:
score=1 | | GABARAPL1 | Q9H0R81, 3 | EBI-367376,EBI-3240381 I2D:
score=1 | | GABARAPL2 | P605201, 3 | EBI-367376,EBI-2973440 I2D:
score=1 |
About this table
Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table
STK4 for ontologies About GeneDecksing
|
Drugs & Compounds
for STK4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
STK4 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for STK4 |
 Browse Tocris compounds for STK4
3 HMDB Compounds for STK4 About this table
3 Novoseek chemical compound relationships for STK4 gene About this table
Search CenterWatch for drugs/clinical trials and news about STK4
|
Transcripts
for STK4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STK4 gene: NM_006282.2 Unigene Cluster for STK4: Serine/threonine kinase 4 Hs.472838 [show with all ESTs]Unigene Representative Sequence: NM_0062828 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372806(uc010ggw.1 uc002xnb.3 uc010ggx.3 uc010ggy.3)
ENST00000488618 ENST00000372801 ENST00000480745 ENST00000487587 ENST00000474717
ENST00000499879 ENST00000396731
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STK4 (NM_006282) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STK4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK4 |
Additional cDNA sequence: AB209315.1 AK027088.1 AK225326.1 AK309169.1 AK315238.1 BC005231.1 BC015332.1 BC029511.1 BC038850.1 BC039023.1 BC042861.1 BC058916.1 BC065215.1 BC093768.1 CR933633.1 U18297.1 U60207.1 Z25430.1 12 DOTS entries: DT.412608 DT.95156860 DT.412609 DT.100693531 DT.206896 DT.97788691 DT.95150770 DT.120806183 DT.99956859 DT.99959178 DT.40233377 DT.432183 24/205 AceView cDNA sequences (see all 205): BP354369 CK429889 AA344604 BX954336 AA465628 BG236802 AA381834 BC038850 T98024 BM992997 T80822 BC058916 BQ223585 CB108083 BQ216721 BI334939 AL710164 AA953504 BC015332 BP354402 AW007657 AA455248 AL597960 BU902081
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for STK4 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for STK4
|
Expression
for STK4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STK4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See STK4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STK4
SOURCE GeneReport for Unigene cluster: Hs.472838
UniProtKB/Swiss-Prot: STK4_HUMAN, Q13043Tissue specificity: Expressed in prostate cancer and levels increase from the normal to the malignant state (at proteinlevel). Ubiquitously expressed
SABiosciences Custom PCR Arrays for STK4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STK4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STK4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STK4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STK4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK4 |
Orthologs
for STK4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for STK4 gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
STK41 |
serine/threonine kinase 4 |
82.17(n)
92.39(a) |
|
419187 NM_001030853.1 NP_001026024.1 |
lizard
(Anolis carolinensis) |
Reptilia |
STK46 |
-- |
87(a) |
1 ↔ 1 |
4(143478889-143519802) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC687622 |
hypothetical protein MGC68762 |
77.21(n) |
|
BC060493.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG112283 |
protein amino acid phosphorylation receptor
signaling more |
50(a) |
|
56D13 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
C24A8.4a3 |
G-protein coupled receptor |
61(a)
(best of 4) |
|
X(4365362-4371318) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SIK11 |
protein kinase domain-containing protein |
50.82(n)
44.51(a) |
|
843253 NM_179534.2 NP_849865.1 |
rice
(Oryza sativa) |
Liliopsida |
Os03g07550001 |
hypothetical protein |
53.99(n)
46.2(a) |
|
4334150 NM_001057845.1 NP_001051310.1 |
ENSEMBL Gene Tree for STK4 (if available)
TreeFam Gene Tree for STK4 (if available) |
Paralogs
for STK4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STK4 gene
- STK242 STK32 STK252 MST42
18/53 SIMAP similar genes for STK4 using alignment to 3 protein entries: STK4_HUMAN (see all proteins)
(see all similar genes):STK4/SLC36AL fusion DKFZp686A2068 STK3 CDK2 CDKL2 MAP4K5
STK25 MYO3A MAP4K1 PAK1 PAK3 MST4
MAP4K3 MYO3B STK24 PAK7 CDK7 MST094
STK4 for paralogs About GeneDecksing
|
Genomic Variants
for STK4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STK4 (43595115 - 43708600 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for STK4
1 CNV: 6112
Human Gene Mutation Database (HGMD): STK4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STK4 |
|
Disorders
/ Diseases
for STK4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STK4 for disorders About GeneDecksing
OMIM gene information: 604965
OMIM disorders: --
13  diseases for STK4: About MalaCardssoft tissue sarcoma squamous cell carcinoma polyposis sarcoma
ovarian carcinoma hepatocellular carcinoma colorectal cancer lung cancer
carcinoma prostate cancer breast cancer prostatitis
neuronitis
3 Novoseek disease relationships for STK4 gene About this table
Human Genome Epidemiology (HuGE) Navigator: STK4 (2 documents)
Export disorders for STK4 gene to outside databases
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Publications
for STK4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for STK4 gene, integrated from 9 sources (see all 106):
(articles sorted by number of sources associating them with STK4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation. (PubMed id 11517310)1, 2, 3, 9 Ura S.... Gotoh Y. (2001)
- Newly identified stress-responsive protein kinases, Krs-1 and Krs- 2. (PubMed id 8816758)1, 2, 3 Taylor L.K.... Erikson R.L. (1996)
- Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. (PubMed id 15109305)1, 2, 9 Praskova M.... Avruch J. (2004)
- Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1. (PubMed id 18986304)1, 2, 9 You B....Sun J. (2009)
- Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. (PubMed id 16510573)1, 2, 9 Oh H.J.... Lim D.-S. (2006)
- Cloning and characterization of a human protein kinase with homology to Ste20. (PubMed id 7665586)1, 2, 9 Creasy C.L. and Chernoff J. (1995)
- Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120. (PubMed id 19940129)1, 2, 9 Yuan Z....Cheng J.Q. (2010)
- MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. (PubMed id 11278283)1, 2, 9 Lee K.-K.... Yonehara S. (2001)
- A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. (PubMed id 16751106)1, 2, 9 Lehtinen M.K.... Bonni A. (2006)
- MST1 promotes apoptosis through regulating Sirt1-depe ndent p53 deacetylation. (PubMed id 21212262)1, 2 Yuan F....Yuan Z. (2011)
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External Searches for STK4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing STK4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing STK4 gene
(According to HUGE)
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| -- |
Specialized Databases showing STK4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for STK4 gene:
Search GeneIP for patents involving STK4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for STK4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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