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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STK39 Gene

protein-coding   GIFtS: 62
GCID: GC02M168774

serine threonine kinase 39
 Explore 9 diseases affiliated with
STK39 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STK39    

Aliases
for STK39 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Serine Threonine Kinase 391 2     Proline-Alanine-Rich STE20-Related Kinase2
SPAK1 2 3 5     Serine Threonine Kinase 39 (STE20/SPS1 Homolog, Yeast)2
DCHT1 2 3     Small Intestine SPAK-Like Kinase2
Serine/Threonine-Protein Kinase 392 3     Ste20-Like Protein Kinase2
Ste-20-Related Kinase2 3     STE20/SPS1 Homolog2
EC 2.7.11.13 8     STE20/SPS1-Related Proline-Alanine-Rich Protein Kinase2
PASK2     EC 2.7.118

External Ids:    HGNC: 177171   Entrez Gene: 273472   Ensembl: ENSG000001986487   OMIM: 6076485   UniProtKB: Q9UEW83   

Export aliases for STK39 gene to outside databases

Previous GC identifers: GC02M166862 GC02M167352 GC02M169013 GC02M168636 GC02M168518 GC02M160690


Summaries
for STK39 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for STK39:
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The
kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled
cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction
with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to
cellular stress. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: STK39_HUMAN, Q9UEW8
Function: May act as a mediator of stress-activated signals

Gene Wiki entry for STK39


Genomic Views
for STK39 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STK39 gene promoter:
         c-Fos   Sp1   AP-1   HSF2   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STK39 promoter sequence
   Search SABiosciences Chromatin IP Primers for STK39

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK39


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.3   Ensembl cytogenetic band:  2q24.3   HGNC cytogenetic band: 2q24.3

STK39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK39 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M168774:  view genomic region     (about GC identifiers)

Start:
 168,810,530 bp from pter      End:
 169,104,651 bp from pter
Size:
 294,122 bases      Orientation:
 minus strand

Proteins
for STK39 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STK39_HUMAN, Q9UEW8 (See protein sequence)
Recommended Name: STE20/SPS1-related proline-alanine-rich protein kinase  
Size: 545 amino acids; 59474 Da
Subunit: The phosphorylated form forms a complex with WNK2 (By similarity)
Subcellular location: Cytoplasm (Probable). Nucleus (Probable). Note=Nucleus when caspase-cleaved (Probable)
Secondary accessions: O14774 Q53S90 Q53SL7 Q53SS1 Q9UER4

Explore the universe of human proteins at neXtProt for STK39: NX_Q9UEW8

Post-translational modifications:

  • Phosphorylated at Ser-309 by PRKCQ1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UEW8

    • 4/15 DME Specific Peptides for STK39 (Q9UEW8) (see all 15)
     RGYDFKA  GITAIEL  KAGNILL  ILLGEDG 

    STK39 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_037365.2  
    ENSEMBL proteins: 
     ENSP00000348278  

    Human Recombinant Protein Products: 
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    Novus Biologicals STK39 Proteins
    Novus Biologicals STK39 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for STK39

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005634nucleus NAS10980603
    GO:0005737cytoplasm NAS10980603
    GO:0005856cytoskeleton IEA--
    GO:0016323basolateral plasma membrane IEA--


    STK39 for ontologies           About GeneDecksing



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    Assay Products for STK39: 
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    Uscn ELISAs and CLIAs for STK39

    Protein Domains /
    Families
    for STK39 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STK39 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR024678 Kinase_OSR1/WNK_CCT
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9UEW8

    ProtoNet protein and cluster: Q9UEW8

    UniProtKB/Swiss-Prot: STK39_HUMAN, Q9UEW8
    Domain: PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating
    interaction with intracellular proteins such as actin or actin-like proteins
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for STK39 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STK39_HUMAN, Q9UEW8
    Function: May act as a mediator of stress-activated signals
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
    Products:            		 OriGene 3'-UTR Clone: STK39
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STK39
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate STK39 (see all 47):
    hsa-miR-323-3p hsa-miR-4328 hsa-miR-513a-5p hsa-miR-25 hsa-miR-128 hsa-miR-16-1* hsa-miR-30d hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmid: STK39 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STK39 (see all 7)
    OriGene shRNA RFP: STK39
    OriGene siRNA: STK39
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STK39

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for STK39

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK39 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: STK39 (NM_013233)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK39 

    Cell Line
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    Search LifeMap BioReagents cell lines for STK39

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004702receptor signaling protein serine/threonine kinase activity NAS10980603
    GO:0005515protein binding ----
    GO:0005524ATP binding NAS--
    GO:0019901protein kinase binding IEA--


    STK39 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for STK39:
     Decreased substrate adherent c  Gemcitabine induced cell-death  Increased cell death HMECs cel  Increased cell death in breast 
     Increased colony dispersion (i  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for STK39: Stk39tm1Dlp Stk39tm1.2Slin
         6 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Stk39):
     cardiovascular system  homeostasis/metabolism  nervous system  no phenotypic analysis  renal/urinary system 
     reproductive system 

    STK39 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for STK39 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00
    2Diuretics Pathway, Pharmacodynamics
    		Diuretics Pathway, Pharmacodynamics1.00
    3TCR signaling in naive CD4+ T cells
    		TCR signaling in naive CD4+ T cells1.00
    4Sweet Taste Signaling
    		Sperm Motility0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for STK39
        Sperm Motility

    1 Cell Signaling Technology (CST) Pathway for STK39
        Cytoskeletal Signaling

    1 BioSystems Pathway for STK39 
        TCR signaling in naive CD4+ T cells

    1 PharmGKB Pathway for STK39
        Diuretics Pathway, Pharmacodynamics


    STK39 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STK39

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/22 Interacting proteins for STK39 (Q9UEW82, 3 ENSP000003482784) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAB39Q9Y3762, 3, ENSP000002584184MINT-8186640 MINT-8186728 MINT-8186626 MINT-8186556 I2D: score=1 STRING: ENSP00000258418
    SLC12A2P550113, ENSP000002624614I2D: score=4 STRING: ENSP00000262461
    WNK4Q96J923, ENSP000002469144I2D: score=3 STRING: ENSP00000246914
    CD46P155293, ENSP000003138754I2D: score=2 STRING: ENSP00000313875
    MBPP026863, ENSP000003482734I2D: score=2 STRING: ENSP00000348273
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation NAS10980603
    GO:0006950response to stress NAS10980603
    GO:0023014signal transduction by phosphorylation NAS10980603
    GO:0043268positive regulation of potassium ion transport IEA--
    GO:0050727regulation of inflammatory response IEA--


    STK39 for ontologies           About GeneDecksing



    Drugs & Compounds
    for STK39 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STK39 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STK39

    2 HMDB Compounds for STK39    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    6 Novoseek chemical compound relationships for STK39 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 74.6 18 16083423 (1), 16173916 (1), 19470686 (1), 16734747 (1) (see all 14)
    threonine 60.4 5 16173916 (1), 19114657 (1), 16734747 (1), 17321610 (1) (see all 5)
    lysine 54 7 16832045 (1), 16669787 (1), 17321610 (1), 17223794 (1) (see all 5)
    serine 48.6 10 16263722 (2), 16083423 (1), 19114657 (1), 16734747 (1) (see all 6)
    nacl 38.1 1 20375989 (1)
    chloride 37.5 5 16734747 (1), 16832045 (1), 16669787 (1), 18985800 (1)

    Search CenterWatch for drugs/clinical trials and news about STK39 

    Transcripts
    for STK39 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STK39 gene: 
    NM_013233.2  

    Unigene Cluster for STK39:

    Serine threonine kinase 39
    Hs.276271  [show with all ESTs]
    Unigene Representative Sequence: AF099989
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487143 ENST00000355999(uc002uea.3) ENST00000461000

    miRNA
    Products:             		 OriGene 3'-UTR Clone: STK39
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STK39
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate STK39 (see all 47):
    hsa-miR-323-3p hsa-miR-4328 hsa-miR-513a-5p hsa-miR-25 hsa-miR-128 hsa-miR-16-1* hsa-miR-30d hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmid: STK39 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STK39 (see all 7)
    OriGene shRNA RFP: STK39
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STK39
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF017635.1 AF030403.1 AF099989.1 BC146813.1 BX647113.1 BX648046.1 

    9 DOTS entries:

    DT.452075  DT.95298308  DT.100784324  DT.101955129  DT.120961521  DT.95132869  DT.120961537  DT.120961544 
    DT.91851100 

    24/210 AceView cDNA sequences (see all 210):

    BM995525 CB159012 BM454626 BM851722 H88348 AA278967 BM702759 AA916960 
    CA393048 BU674958 AA766905 CF887100 AI286193 BM667597 AA370646 AA259102 
    AA150717 AW513903 BM789929 AA824515 AI266366 CK819805 BF593764 CB146701 

    GeneLoc Exon Structure


    Expression
    for STK39 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STK39 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCCACCGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    STK39 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See STK39 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STK39

    SOURCE GeneReport for Unigene cluster: Hs.276271

    UniProtKB/Swiss-Prot: STK39_HUMAN, Q9UEW8
    Tissue specificity: Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle,
    liver, placenta and testis

        SABiosciences Custom PCR Arrays for STK39
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK39

    Orthologs
    for STK39 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STK39 gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves STK396
    		 Uncharacterized protein
    		 91(a)
    		 1 ↔ 1
    		 7(20566200-20640399)
    lizard
    (Anolis carolinensis)    		 Reptilia STK396
    		 --
    		 92(a)
    		 1 ↔ 1
    		 1(245648895-245722330)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia BX703708.12   -- 79.43(n)    BX703708.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii oxsr1a1 oxidative-stress responsive 1a 69.46(n)
    78.37(a)    		   568602  NM_001098747.1  NP_001092217.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta fray3 embryonic cuticle biosynthesis (sensu
    Insecta) more    		 54(a)   91B5   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y59A8B.233   -- 55(a)   V(17956707-17967938)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G237006
    AT1G704306
    (see all 7)    		 protein kinase-like protein
    (see all 7)    		 29(a)
    27(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 1(8379454-8381965)
    1(26545414-26549216)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 6)    		 STE_PAK_Ste20_STLK.1 - STE kinases include homolog...
    STE_PAK_Ste20_STLK.2 - STE kinases include homolog...
    (see all 6)    		 34(a)
    26(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 2(4376785-4380320)
    2(33617887-33624174)


    ENSEMBL Gene Tree for STK39 (if available)
    TreeFam Gene Tree for STK39 (if available) 

    Paralogs
    for STK39 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STK39 gene
    OXSR12  STRADB2  STRADA2  
    5 SIMAP similar genes for STK39 using alignment to 1 protein entry:     STK39_HUMAN:
    OXSR1    STK24    MST4    STK25    NEK7

    STK39 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STK39
    PGOHUM00000246061


    Genomic Variants
    for STK39 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5706 NCBI SNPs in STK39 are shown (see all 5706)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs75953101,2
    		C,F,A,H,--168810137(+) AGGAAG/ATGAGG 1 -- ds500122Minor allele frequency- A:0.46NS EA NA WA CSA 2344
    rs1466712261,2
    		--168810229(+) CAGCAC/TTAAAA 1 -- ds50010--------
    rs1391614811,2
    		--168810279(+) CTATAA/GCCCTA 1 -- ds50010--------
    rs76094341,2
    		C,F,A,H,--168810294(+) GGTTTT/AAATTC 1 -- ds500112Minor allele frequency- A:0.31NS EA WA NA CSA 787
    rs1888350151,2
    		--168810452(+) TACTAA/GGCATT 1 -- ds50010--------
    rs1499071181,2
    		C,--168810634(+) GTATGC/TAAATG 1 -- ut310--------
    rs37694291,2
    		H--168810739(-) TAGATA/GTGGCA 1 -- ut31 ese35Minor allele frequency- G:0.00EA NS 1912
    rs1817912351,2
    		--168810774(+) TACCAC/TCCTGG 1 -- ut310--------
    rs1864522011,2
    		--168810856(+) TCAAGC/GAGAGG 1 -- ut310--------
    rs1489799021,2
    		--168810902(+) AACAGC/TGTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for STK39 (168810530 - 169060530 bp, first 250kb of STK39)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for STK39
         2 Indels: 45900 42880
    Human Gene Mutation Database (HGMD): STK39

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    Disorders / Diseases
    for STK39 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STK39 for disorders           About GeneDecksing

    OMIM gene information: 607648    OMIM disorders: --

    9 diseases for STK39:    About MalaCards
    b-cell lymphomas    pseudohypoaldosteronism    glanders    essential hypertension
    hypertension    parkinson's disease    lung cancer    prostate cancer
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for STK39:
    Glanders
    Human Genome Epidemiology (HuGE) Navigator: STK39 (10 documents)

    Export disorders for STK39 gene to outside databases

    Publications
    for STK39 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STK39 gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with STK39)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. (PubMed id 10980603)1, 2, 3 Johnston A.M....de Aizpurua H.J. (2000)
    2. TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis. (PubMed id 16950202)1, 9 Polek T.C....Spivak-Kroizman T.R. (2006)
    3. PKCdelta acts upstream of SPAK in the activation of NKCC1 by hyperosmotic stress in human airway epithelial cells. (PubMed id 18550547)1, 9 Smith L....Liedtke C.M. (2008)
    4. Cloning and characterization of a new intestinal inflammation- associated colonic epithelial Ste20-related protein kinase isoform. (PubMed id 17321610)1, 9 Yan Y.... Merlin D. (2007)
    5. WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. (PubMed id 16263722)1, 9 Moriguchi T....Shibuya H. (2005)
    6. Epigenetic silencing of Stk39 in B-cell lymphoma inhi bits apoptosis from genotoxic stress. (PubMed id 19717643)1, 9 Balatoni C.E....Teitell M.A. (2009)
    7. From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene. (PubMed id 19114657)1, 9 Wang Y....Chang Y.P. (2009)
    8. An analysis of candidate autism loci on chromosome 2q24-q33: Evidence for association to the STK39 gene. (PubMed id 18348195)1, 9 Ramoz N....Buxbaum J.D. (2008)
    9. Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. (PubMed id 16669787)1, 9 Vitari A.C....Alessi D.R. (2006)
    10. Renal and brain isoforms of WNK3 have opposite effect s on NCCT expression. (PubMed id 19470686)1, 9 Glover M....O'Shaughnessy K.M. (2009)

    External Searches for STK39 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing STK39 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27347 HGNC: 17717 AceView: STK39 Ensembl:ENSG00000198648 euGenes: HUgn27347
    ECgene: STK39 H-InvDB: STK39

    Other Databases showing STK39 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STK39 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STK39 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for STK39 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STK39 gene:
    Search GeneIP for patents involving STK39

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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