Aliases for STK39 Gene
External Ids for STK39 Gene
Previous GeneCards Identifiers for STK39 Gene
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]
GeneCards Summary for STK39 Gene
STK39 (Serine/Threonine Kinase 39) is a Protein Coding gene. Diseases associated with STK39 include Gitelman Syndrome and Renal Tubular Transport Disease. Among its related pathways are Sweet Taste Signaling and Diuretics Pathway, Pharmacodynamics. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is OXSR1.
UniProtKB/Swiss-Prot for STK39 Gene
May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation.