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Aliases for STK39 Gene

Aliases for STK39 Gene

  • Serine/Threonine Kinase 39 2 3 5
  • Serine/Threonine-Protein Kinase 39 3 4
  • Ste-20-Related Kinase 3 4
  • EC 2.7.11.1 4 63
  • DCHT 3 4
  • SPAK 3 4
  • Serine Threonine Kinase 39 (STE20/SPS1 Homolog, Yeast) 3
  • Proline-Alanine-Rich STE20-Related Kinase 3
  • Small Intestine SPAK-Like Kinase 3
  • STE20/SPS1 Homolog (Yeast) 2
  • Serine Threonine Kinase 39 2
  • Ste20-Like Protein Kinase 3
  • STE20/SPS1 Homolog 3
  • EC 2.7.11 63
  • PASK 3

External Ids for STK39 Gene

Previous GeneCards Identifiers for STK39 Gene

  • GC02M166862
  • GC02M167352
  • GC02M168774
  • GC02M169013
  • GC02M168636
  • GC02M168518
  • GC02M160690

Summaries for STK39 Gene

Entrez Gene Summary for STK39 Gene

  • This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK39 Gene

STK39 (Serine/Threonine Kinase 39) is a Protein Coding gene. Diseases associated with STK39 include Gitelman Syndrome and Renal Tubular Transport Disease. Among its related pathways are Sweet Taste Signaling and Diuretics Pathway, Pharmacodynamics. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is OXSR1.

UniProtKB/Swiss-Prot for STK39 Gene

  • May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation.

Gene Wiki entry for STK39 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK39 Gene

Genomics for STK39 Gene

Regulatory Elements for STK39 Gene

Enhancers for STK39 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STK39 on UCSC Golden Path with GeneCards custom track

Promoters for STK39 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STK39 on UCSC Golden Path with GeneCards custom track

Genomic Location for STK39 Gene

Chromosome:
2
Start:
167,954,020 bp from pter
End:
168,248,141 bp from pter
Size:
294,122 bases
Orientation:
Minus strand

Genomic View for STK39 Gene

Genes around STK39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK39 Gene

Proteins for STK39 Gene

  • Protein details for STK39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UEW8-STK39_HUMAN
    Recommended name:
    STE20/SPS1-related proline-alanine-rich protein kinase
    Protein Accession:
    Q9UEW8
    Secondary Accessions:
    • O14774
    • Q53S90
    • Q53SL7
    • Q53SS1
    • Q9UER4
    • X5D9C8

    Protein attributes for STK39 Gene

    Size:
    545 amino acids
    Molecular mass:
    59474 Da
    Quaternary structure:
    • The phosphorylated form forms a complex with WNK2.

    Alternative splice isoforms for STK39 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK39 Gene

Proteomics data for STK39 Gene at MOPED

Post-translational modifications for STK39 Gene

Other Protein References for STK39 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STK39 (STLK3)

Domains & Families for STK39 Gene

Gene Families for STK39 Gene

Suggested Antigen Peptide Sequences for STK39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UEW8

UniProtKB/Swiss-Prot:

STK39_HUMAN :
  • PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STK39: view

Function for STK39 Gene

Molecular function for STK39 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation.

Enzyme Numbers (IUBMB) for STK39 Gene

Gene Ontology (GO) - Molecular Function for STK39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with STK39: view
genes like me logo Genes that share phenotypes with STK39: view

Animal Models for STK39 Gene

MGI Knock Outs for STK39:

Animal Model Products

  • Taconic Biosciences Mouse Models for STK39

CRISPR Products

miRNA for STK39 Gene

miRTarBase miRNAs that target STK39

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK39 Gene

Localization for STK39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK39 Gene

Cytoplasm. Nucleus. Note=Nucleus when caspase-cleaved. {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK39 Gene COMPARTMENTS Subcellular localization image for STK39 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 3
cytoskeleton 2
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for STK39 Gene

Pathways & Interactions for STK39 Gene

genes like me logo Genes that share pathways with STK39: view

Pathways by source for STK39 Gene

1 Cell Signaling Technology pathway for STK39 Gene
1 BioSystems pathway for STK39 Gene
1 PharmGKB pathway for STK39 Gene
1 Qiagen pathway for STK39 Gene

SIGNOR curated interactions for STK39 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for STK39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0006468 protein phosphorylation IEA,NAS 10980603
GO:0006950 response to stress NAS 10980603
GO:0007346 regulation of mitotic cell cycle IBA --
GO:0008217 regulation of blood pressure IEA --
genes like me logo Genes that share ontologies with STK39: view

Drugs & Compounds for STK39 Gene

(6) Drugs for STK39 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Losartan Approved Pharma Antagonist 277
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for STK39 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK39: view

Transcripts for STK39 Gene

Unigene Clusters for STK39 Gene

Serine threonine kinase 39:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK39 Gene

No ASD Table

Relevant External Links for STK39 Gene

GeneLoc Exon Structure for
STK39
ECgene alternative splicing isoforms for
STK39

Expression for STK39 Gene

mRNA expression in normal human tissues for STK39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STK39 Gene

This gene is overexpressed in Salivary gland (8.9) and Frontal cortex (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STK39 Gene



SOURCE GeneReport for Unigene cluster for STK39 Gene Hs.276271

mRNA Expression by UniProt/SwissProt for STK39 Gene

Q9UEW8-STK39_HUMAN
Tissue specificity: Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis.
genes like me logo Genes that share expression patterns with STK39: view

Protein tissue co-expression partners for STK39 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for STK39 Gene

Orthologs for STK39 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STK39 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia STK39 35
  • 94.68 (n)
  • 98.32 (a)
STK39 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk39 35
  • 90.81 (n)
  • 96.51 (a)
Stk39 16
Stk39 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STK39 35
  • 99.51 (n)
  • 99.82 (a)
STK39 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk39 35
  • 90.62 (n)
  • 96.51 (a)
cow
(Bos Taurus)
Mammalia STK39 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK39 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK39 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK39 35
  • 85.11 (n)
  • 94.77 (a)
STK39 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK39 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488948 35
  • 78.25 (n)
  • 87.12 (a)
zebrafish
(Danio rerio)
Actinopterygii oxsr1a 35
  • 69.46 (n)
  • 78.37 (a)
CABZ01117519.1 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fray 37
  • 54 (a)
fray 36
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y59A8B.23 37
  • 55 (a)
gck-3 36
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLA4 36
  • 13 (a)
ManyToMany
SKM1 36
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9457 36
  • 59 (a)
OneToMany
Species with no ortholog for STK39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK39 Gene

ENSEMBL:
Gene Tree for STK39 (if available)
TreeFam:
Gene Tree for STK39 (if available)

Paralogs for STK39 Gene

Paralogs for STK39 Gene

(5) SIMAP similar genes for STK39 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for STK39 Gene

genes like me logo Genes that share paralogs with STK39: view

Variants for STK39 Gene

Sequence variations from dbSNP and Humsavar for STK39 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs715878 -- 168,050,131(+) TTGGC(A/G)TACAC intron-variant
rs729872 -- 167,989,799(-) GTTCA(A/G)AATTT intron-variant
rs1554239 -- 168,239,076(+) TATAA(G/T)TTATA intron-variant
rs1554240 -- 168,239,562(+) AATAA(A/G)CCCCA intron-variant
rs735893 -- 167,989,726(+) AAATA(C/T)CACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK39 Gene

Variant ID Type Subtype PubMed ID
esv2668311 CNV Deletion 23128226
esv2670762 CNV Deletion 23128226
nsv523543 CNV Loss 19592680
esv2721096 CNV Deletion 23290073
esv2721097 CNV Deletion 23290073
esv5404 CNV Deletion 18987735
esv275050 CNV Gain+Loss 21479260
esv2214356 CNV Deletion 18987734
nsv3022 CNV Insertion 18451855
nsv459941 CNV Gain 19166990
nsv522749 CNV Loss 19592680
esv2721098 CNV Deletion 23290073
esv999027 CNV Deletion 20482838
esv1331913 CNV Deletion 17803354
esv2665325 CNV Deletion 23128226

Variation tolerance for STK39 Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.62; 94.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK39 Gene

Human Gene Mutation Database (HGMD)
STK39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK39 Gene

Disorders for STK39 Gene

MalaCards: The human disease database

(2) MalaCards diseases for STK39 Gene - From: DISEASES

Disorder Aliases PubMed IDs
gitelman syndrome
  • hypomagnesemia-hypokalemia, primary renotubular, with hypocalciuria
renal tubular transport disease
  • inborn renal tubular transport disorder
- elite association - COSMIC cancer census association via MalaCards
Search STK39 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STK39

Genetic Association Database (GAD)
STK39
Human Genome Epidemiology (HuGE) Navigator
STK39
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK39
genes like me logo Genes that share disorders with STK39: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK39 Gene

Publications for STK39 Gene

  1. SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. (PMID: 10980603) Johnston A.M. … de Aizpurua H.J. (Oncogene 2000) 2 3 4 67
  2. From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene. (PMID: 19114657) Wang Y. … Chang Y.P. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  3. Renal and brain isoforms of WNK3 have opposite effects on NCCT expression. (PMID: 19470686) Glover M. … O'Shaughnessy K.M. (J. Am. Soc. Nephrol. 2009) 3 23
  4. Epigenetic silencing of Stk39 in B-cell lymphoma inhibits apoptosis from genotoxic stress. (PMID: 19717643) Balatoni C.E. … Teitell M.A. (Am. J. Pathol. 2009) 3 23
  5. Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1. (PMID: 18270262) Richardson C. … Alessi D.R. (J. Cell. Sci. 2008) 3 23

Products for STK39 Gene

Sources for STK39 Gene

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