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Aliases for STK39 Gene

Aliases for STK39 Gene

  • Serine Threonine Kinase 39 2 3
  • SPAK 3 4 6
  • Serine/Threonine-Protein Kinase 39 3 4
  • Ste-20-Related Kinase 3 4
  • EC 4 63
  • DCHT 3 4
  • STE20/SPS1-Related Proline-Alanine-Rich Protein Kinase 3
  • Serine Threonine Kinase 39 (STE20/SPS1 Homolog, Yeast) 3
  • Proline-Alanine-Rich STE20-Related Kinase 3
  • Small Intestine SPAK-Like Kinase 3
  • STE20/SPS1 Homolog (Yeast) 2
  • Ste20-Like Protein Kinase 3
  • STE20/SPS1 Homolog 3
  • EC 2.7.11 63
  • PASK 3

External Ids for STK39 Gene

Previous GeneCards Identifiers for STK39 Gene

  • GC02M166862
  • GC02M167352
  • GC02M168774
  • GC02M169013
  • GC02M168636
  • GC02M168518
  • GC02M160690

Summaries for STK39 Gene

Entrez Gene Summary for STK39 Gene

  • This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK39 Gene

STK39 (Serine Threonine Kinase 39) is a Protein Coding gene. Diseases associated with STK39 include glanders. Among its related pathways are Cytoskeletal Signaling and Glucose / Energy Metabolism. GO annotations related to this gene include protein kinase binding and receptor signaling protein serine/threonine kinase activity. An important paralog of this gene is OXSR1.

UniProtKB/Swiss-Prot for STK39 Gene

  • May act as a mediator of stress-activated signals

Gene Wiki entry for STK39 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK39 Gene

Genomics for STK39 Gene

Regulatory Elements for STK39 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STK39 Gene

167,954,020 bp from pter
168,248,141 bp from pter
294,122 bases
Minus strand

Genomic View for STK39 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STK39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK39 Gene

Proteins for STK39 Gene

  • Protein details for STK39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    STE20/SPS1-related proline-alanine-rich protein kinase
    Protein Accession:
    Secondary Accessions:
    • O14774
    • Q53S90
    • Q53SL7
    • Q53SS1
    • Q9UER4
    • X5D9C8

    Protein attributes for STK39 Gene

    545 amino acids
    Molecular mass:
    59474 Da
    Quaternary structure:
    • The phosphorylated form forms a complex with WNK2.

    Alternative splice isoforms for STK39 Gene


neXtProt entry for STK39 Gene

Proteomics data for STK39 Gene at MOPED

Post-translational modifications for STK39 Gene

Other Protein References for STK39 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STK39 (STLK3)

Domains for STK39 Gene

Gene Families for STK39 Gene

Suggested Antigen Peptide Sequences for STK39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UEW8
  • PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STK39: view

Function for STK39 Gene

Molecular function for STK39 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: May act as a mediator of stress-activated signals

Enzyme Numbers (IUBMB) for STK39 Gene

Gene Ontology (GO) - Molecular Function for STK39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 24393035
GO:0004702 receptor signaling protein serine/threonine kinase activity NAS 10980603
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 21423148
genes like me logo Genes that share ontologies with STK39: view
genes like me logo Genes that share phenotypes with STK39: view

Animal Models for STK39 Gene

MGI Knock Outs for STK39:

Animal Model Products

CRISPR Products

miRNA for STK39 Gene

miRTarBase miRNAs that target STK39

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STK39

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for STK39 Gene

Localization for STK39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK39 Gene

Cytoplasm. Nucleus. Note=Nucleus when caspase-cleaved. {ECO:0000305}.

Subcellular locations from

Jensen Localization Image for STK39 Gene COMPARTMENTS Subcellular localization image for STK39 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
plasma membrane 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STK39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10980603
GO:0005737 cytoplasm NAS 10980603
GO:0005856 cytoskeleton IEA --
GO:0016020 membrane --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with STK39: view

Pathways for STK39 Gene

genes like me logo Genes that share pathways with STK39: view

Pathways by source for STK39 Gene

1 Qiagen pathway for STK39 Gene
2 Cell Signaling Technology pathways for STK39 Gene
1 BioSystems pathway for STK39 Gene
1 PharmGKB pathway for STK39 Gene

Gene Ontology (GO) - Biological Process for STK39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation NAS 10980603
GO:0006950 response to stress NAS 10980603
GO:0018105 peptidyl-serine phosphorylation IDA 24393035
GO:0018107 peptidyl-threonine phosphorylation IDA 24393035
GO:0023014 signal transduction by protein phosphorylation IDA 24393035
genes like me logo Genes that share ontologies with STK39: view

Compounds for STK39 Gene

(2) HMDB Compounds for STK39 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure

(6) Novoseek inferred chemical compound relationships for STK39 Gene

Compound -log(P) Hits PubMed IDs
proline 74.6 14
threonine 60.4 5
lysine 54 5
serine 48.6 7
nacl 38.1 1

(1) PharmGKB related drug/compound annotations for STK39 Gene

Drug/compound Annotation
losartan CA
genes like me logo Genes that share compounds with STK39: view

Transcripts for STK39 Gene

Unigene Clusters for STK39 Gene

Serine threonine kinase 39:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STK39

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for STK39

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK39 Gene

No ASD Table

Relevant External Links for STK39 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STK39 Gene

mRNA expression in normal human tissues for STK39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STK39 Gene

SOURCE GeneReport for Unigene cluster for STK39 Gene Hs.276271

mRNA Expression by UniProt/SwissProt for STK39 Gene

Tissue specificity: Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis
genes like me logo Genes that share expressions with STK39: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for STK39 Gene

Orthologs for STK39 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STK39 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STK39 35
  • 99.51 (n)
  • 99.82 (a)
STK39 36
  • 100 (a)
(Bos Taurus)
Mammalia STK39 36
  • 89 (a)
(Canis familiaris)
Mammalia STK39 35
  • 94.68 (n)
  • 98.32 (a)
STK39 36
  • 90 (a)
(Mus musculus)
Mammalia Stk39 35
  • 90.81 (n)
  • 96.51 (a)
Stk39 16
Stk39 36
  • 95 (a)
(Monodelphis domestica)
Mammalia STK39 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia STK39 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Stk39 35
  • 90.62 (n)
  • 96.51 (a)
(Gallus gallus)
Aves STK39 35
  • 85.11 (n)
  • 94.77 (a)
STK39 36
  • 82 (a)
(Anolis carolinensis)
Reptilia STK39 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488948 35
  • 78.25 (n)
  • 87.12 (a)
(Danio rerio)
Actinopterygii CABZ01117519.1 36
  • 53 (a)
oxsr1a 35
  • 69.46 (n)
  • 78.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta fray 36
  • 54 (a)
fray 37
  • 54 (a)
(Caenorhabditis elegans)
Secernentea gck-3 36
  • 49 (a)
Y59A8B.23 37
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLA4 36
  • 13 (a)
SKM1 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9457 36
  • 59 (a)
Species with no ortholog for STK39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK39 Gene

Gene Tree for STK39 (if available)
Gene Tree for STK39 (if available)

Paralogs for STK39 Gene

Paralogs for STK39 Gene

Selected SIMAP similar genes for STK39 Gene using alignment to 1 proteins: Pseudogenes for STK39 Gene

genes like me logo Genes that share paralogs with STK39: view

Variants for STK39 Gene

Sequence variations from dbSNP and Humsavar for STK39 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3821 -- 167,959,482(+) aaaaa(C/T)gtctg intron-variant
rs715878 -- 168,050,131(+) TTGGC(A/G)TACAC intron-variant
rs729872 -- 167,989,799(-) GTTCA(A/G)AATTT intron-variant
rs735893 -- 167,989,726(+) AAATA(C/T)CACTT intron-variant
rs755844 -- 168,116,561(+) GTTAA(A/G)TCAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK39 Gene

Variant ID Type Subtype PubMed ID
esv2668311 CNV Deletion 23128226
esv2670762 CNV Deletion 23128226
nsv523543 CNV Loss 19592680
esv2721096 CNV Deletion 23290073
esv2721097 CNV Deletion 23290073
esv5404 CNV Deletion 18987735
esv275050 CNV Gain+Loss 21479260
esv2214356 CNV Deletion 18987734
nsv3022 CNV Insertion 18451855
nsv459941 CNV Gain 19166990
nsv522749 CNV Loss 19592680
esv2721098 CNV Deletion 23290073
esv999027 CNV Deletion 20482838
esv1331913 CNV Deletion 17803354
esv2665325 CNV Deletion 23128226

Relevant External Links for STK39 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK39 Gene

Disorders for STK39 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for STK39 Gene including...

Search for STK39 Gene in MalaCards »

(1) University of Copenhagen DISEASES for STK39 Gene

Relevant External Links for STK39

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with STK39: view

No data available for UniProtKB/Swiss-Prot for STK39 Gene

Publications for STK39 Gene

  1. An analysis of candidate autism loci on chromosome 2q24-q33: evidence for association to the STK39 gene. (PMID: 18348195) Ramoz N. … Buxbaum J.D. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23 48
  2. From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene. (PMID: 19114657) Wang Y. … Chang Y.P. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23 48
  3. SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. (PMID: 10980603) Johnston A.M. … de Aizpurua H.J. (Oncogene 2000) 2 3 4
  4. PKCdelta acts upstream of SPAK in the activation of NKCC1 by hyperosmotic stress in human airway epithelial cells. (PMID: 18550547) Smith L. … Liedtke C.M. (J. Biol. Chem. 2008) 3 23
  5. Renal and brain isoforms of WNK3 have opposite effects on NCCT expression. (PMID: 19470686) Glover M. … O'Shaughnessy K.M. (J. Am. Soc. Nephrol. 2009) 3 23

Products for STK39 Gene

Sources for STK39 Gene

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