Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



STK39 Gene

protein-coding   GIFtS: 64
GCID: GC02M168774

Serine Threonine Kinase 39

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Serine Threonine Kinase 391 2     Proline-Alanine-Rich STE20-Related Kinase2
SPAK2 3 5     Serine Threonine Kinase 39 (STE20/SPS1 Homolog, Yeast)2
Serine/Threonine-Protein Kinase 392 3     Small Intestine SPAK-Like Kinase2
Ste-20-Related Kinase2 3     Ste20-Like Protein Kinase2
DCHT2 3     STE20/SPS1 Homolog2
EC 2.7.11.13 8     STE20/SPS1-Related Proline-Alanine-Rich Protein Kinase2
STE20/SPS1 Homolog (Yeast)1     EC 2.7.118
PASK2     

External Ids:    HGNC: 177171   Entrez Gene: 273472   Ensembl: ENSG000001986487   OMIM: 6076485   UniProtKB: Q9UEW83   

Export aliases for STK39 gene to outside databases

Previous GC identifers: GC02M166862 GC02M167352 GC02M169013 GC02M168636 GC02M168518 GC02M160690


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for STK39 Gene:
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway.
The kinase is activated in response to hypotonic stress, leading to phosphorylation of several
cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase
pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an
intermediate in the response to cellular stress. (provided by RefSeq, Jul 2008)

GeneCards Summary for STK39 Gene:
STK39 (serine threonine kinase 39) is a protein-coding gene. Diseases associated with STK39 include pseudohypoaldosteronism, and glanders. GO annotations related to this gene include protein kinase binding and receptor signaling protein serine/threonine kinase activity. An important paralog of this gene is STRADB.

UniProtKB/Swiss-Prot: STK39_HUMAN, Q9UEW8
Function: May act as a mediator of stress-activated signals

Gene Wiki entry for STK39 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STK39 gene promoter:
         c-Fos   Sp1   AP-1   HSF2   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK39 promoter sequence
   Search Chromatin IP Primers for STK39

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK39


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.3   Ensembl cytogenetic band:  2q24.3   HGNC cytogenetic band: 2q24.3

STK39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK39 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M168774:  view genomic region     (about GC identifiers)

Start:
168,810,530 bp from pter      End:
169,104,651 bp from pter
Size:
294,122 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: STK39_HUMAN, Q9UEW8 (See protein sequence)
Recommended Name: STE20/SPS1-related proline-alanine-rich protein kinase  
Size: 545 amino acids; 59474 Da
Subunit: The phosphorylated form forms a complex with WNK2 (By similarity)
Secondary accessions: O14774 Q53S90 Q53SL7 Q53SS1 Q9UER4

Explore the universe of human proteins at neXtProt for STK39: NX_Q9UEW8

Explore proteomics data for STK39 at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-309 by PRKCQ1
  • Ubiquitination2 at Lys83, Lys230, Lys349
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for STK39 (Q9UEW8) (see all 15)
     RGYDFKA  GITAIEL  KAGNILL  ILLGEDG 


    See STK39 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037365.2  
    ENSEMBL proteins: 
     ENSP00000348278  

    STK39 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for STK39
    OriGene Protein Over-expression Lysate for STK39
    OriGene MassSpec for STK39
    OriGene Custom Protein Services for STK39
    GenScript Custom Purified and Recombinant Proteins Services for STK39
    Novus Biologicals STK39 Proteins
    Novus Biologicals STK39 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STK39

    STK39 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for STK39  (STLK3)
    OriGene Antibodies for STK39
    OriGene Custom Antibody Services for STK39
    Novus Biologicals STK39 Antibodies
    Abcam antibodies for STK39
    Cloud-Clone Corp. Antibodies for STK39
    ThermoFisher Antibody for STK39
    LSBio Antibodies in human, mouse, rat for STK39

    STK39 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STK39
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STK39
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STK39
    Cloud-Clone Corp. CLIAs for STK39


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: serine threonine kinase 39
    FRAY subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR024678 Kinase_OSR1/WNK_CCT
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9UEW8

    ProtoNet protein and cluster: Q9UEW8

    UniProtKB/Swiss-Prot: STK39_HUMAN, Q9UEW8
    Domain: PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by
    facilitating interaction with intracellular proteins such as actin or actin-like proteins
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    STK39 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STK39_HUMAN, Q9UEW8
    Function: May act as a mediator of stress-activated signals
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004702receptor signaling protein serine/threonine kinase activity NAS10980603
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
         
    STK39 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for STK39:
     Decreased substrate adherent c  Gemcitabine induced cell-death  Increased cell death HMECs cel  Increased cell death in breast 
     Increased colony dispersion (i  Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Stk39):
     cardiovascular system  homeostasis/metabolism  nervous system  no phenotypic analysis  renal/urinary system 
     reproductive system 

    STK39 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for STK39: Stk39tm1Dlp Stk39tm1.2Slin

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STK39
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STK39

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STK39
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STK39

    miRNA
    Products:
        
    miRTarBase miRNAs that target STK39:
    hsa-mir-215-5p (MIRT024926), hsa-mir-192-5p (MIRT026483)

    Block miRNA regulation of human, mouse, rat STK39 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK39 (see all 47):
    hsa-miR-323-3p hsa-miR-4328 hsa-miR-513a-5p hsa-miR-25 hsa-miR-128 hsa-miR-16-1* hsa-miR-30d hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidSTK39 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STK39
    Predesigned siRNA for gene silencing in human, mouse, rat STK39

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STK39

    Clone
    Products:
         
    OriGene clones in human, mouse for STK39 (see all 7)
    OriGene ORF clones in mouse, rat for STK39
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STK39 (NM_013233)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STK39
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK39

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STK39
    Browse ESI BIO Cell Lines and PureStem Progenitors for STK39 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK39


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    STK39_HUMAN, Q9UEW8: Cytoplasm (Probable). Nucleus (Probable). Note=Nucleus when caspase-cleaved (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton2
    plasma membrane2
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10980603
    GO:0005737cytoplasm NAS10980603
    GO:0005856cytoskeleton IEA--
    GO:0016020membrane ----
    GO:0016323basolateral plasma membrane IEA--

    STK39 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for STK39 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD4+ T cells0.64
    2Sweet Taste Signaling
    Sperm Motility0.37
    3Diuretics Pathway, Pharmacodynamics
    Diuretics Pathway, Pharmacodynamics
    4Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STK39
        Sperm Motility

    1 Cell Signaling Technology (CST) Pathway for STK39
        Cytoskeletal Signaling

    1 BioSystems Pathway for STK39
        TCR signaling in naive CD4+ T cells

    1 PharmGKB Pathway for STK39
        Diuretics Pathway, Pharmacodynamics


    STK39 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STK39
    Interactions:

        GeneGlobe Interaction Network for STK39

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for STK39 (Q9UEW81, 2, 3 ENSP000003482784) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAB39Q9Y3761, 2, 3, ENSP000002584184EBI-2680974,EBI-306905 MINT-8186640 MINT-8186728 MINT-8186626 MINT-8186556 I2D: score=1 STRING: ENSP00000258418
    SLC12A2P550113, ENSP000002624614I2D: score=4 STRING: ENSP00000262461
    WNK4Q96J923, ENSP000002469144I2D: score=3 STRING: ENSP00000246914
    CD46P155293, ENSP000003138754I2D: score=2 STRING: ENSP00000313875
    MBPP026863, ENSP000003482734I2D: score=2 STRING: ENSP00000348273
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation NAS10980603
    GO:0006950response to stress NAS10980603
    GO:0023014signal transduction by phosphorylation NAS10980603
    GO:0043268positive regulation of potassium ion transport IEA--
    GO:0050727regulation of inflammatory response IEA--

    STK39 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STK39

    2 HMDB Compounds for STK39    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    6 Novoseek inferred chemical compound relationships for STK39 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 74.6 18 16083423 (1), 16173916 (1), 19470686 (1), 16734747 (1) (see all 14)
    threonine 60.4 5 16173916 (1), 19114657 (1), 16734747 (1), 17321610 (1) (see all 5)
    lysine 54 7 16832045 (1), 16669787 (1), 17321610 (1), 17223794 (1) (see all 5)
    serine 48.6 10 16263722 (2), 16083423 (1), 19114657 (1), 16734747 (1) (see all 6)
    nacl 38.1 1 20375989 (1)
    chloride 37.5 5 16734747 (1), 16832045 (1), 16669787 (1), 18985800 (1)



    STK39 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for STK39 gene: 
    NM_013233.2  

    Unigene Cluster for STK39:

    Serine threonine kinase 39
    Hs.276271  [show with all ESTs]
    Unigene Representative Sequence: AF099989
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487143 ENST00000355999(uc002uea.3) ENST00000461000

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STK39 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK39 (see all 47):
    hsa-miR-323-3p hsa-miR-4328 hsa-miR-513a-5p hsa-miR-25 hsa-miR-128 hsa-miR-16-1* hsa-miR-30d hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidSTK39 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STK39
    Predesigned siRNA for gene silencing in human, mouse, rat STK39
    Clone
    Products:
         
    OriGene clones in human, mouse for STK39 (see all 7)
    OriGene ORF clones in mouse, rat for STK39
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STK39 (NM_013233)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STK39
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK39
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for STK39
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STK39
      QuantiTect SYBR Green Assays in human, mouse, rat STK39
      QuantiFast Probe-based Assays in human, mouse, rat STK39

    Additional mRNA sequence: 

    AF017635.1 AF030403.1 AF099989.1 BC146813.1 BX647113.1 BX648046.1 

    9 DOTS entries:

    DT.452075  DT.95298308  DT.100784324  DT.101955129  DT.120961521  DT.95132869  DT.120961537  DT.120961544 
    DT.91851100 

    Selected AceView cDNA sequences (see all 210):

    BM995525 AU280258 AW085975 BM981452 BQ574934 AW152645 CF142415 AI858774 
    AA367293 BM141976 AA371056 CB852207 CB269222 CK430366 AI919235 AA669094 
    CB146701 AA393093 BF593764 AA824515 AI266366 CK819805 BM789929 AW513903 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    STK39 expression in normal human tissues (normalized intensities)      STK39 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCACCGCC
    STK39 Expression
    About this image


    STK39 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Outer Root Sheath Cells Outer Root Sheath
     
     Hair (Integumentary System)
             Outer Root Sheath Cells Outer Root Sheath
    STK39 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STK39 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.276271

    UniProtKB/Swiss-Prot: STK39_HUMAN, Q9UEW8
    Tissue specificity: Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal
    muscle, liver, placenta and testis

        Custom PCR Arrays for STK39
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for STK39
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STK39
    QuantiTect SYBR Green Assays in human, mouse, rat STK39
    QuantiFast Probe-based Assays in human, mouse, rat STK39
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK39

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for STK39 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk391 , 5 serine/threonine kinase 39, STE20/SPS1 homolog (yeast)5
    serine/threonine kinase 391
    90.81(n)1
    96.51(a)1
      2 (39.53 cM)5
    534161  NM_016866.21  NP_058562.11 
     682104455 
    chicken
    (Gallus gallus)
    Aves STK391 serine threonine kinase 39 85.11(n)
    94.77(a)
      101751124  XM_004942771.1  XP_004942828.1 
    lizard
    (Anolis carolinensis)
    Reptilia STK396
    serine threonine kinase 39
    86(a)
    1 ↔ 1
    1(245573738-245722447)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX703708.12   -- 79.43(n)    BX703708.1 
    zebrafish
    (Danio rerio)
    Actinopterygii oxsr1a1 oxidative-stress responsive 1a 69.46(n)
    78.37(a)
      568602  NM_001098747.1  NP_001092217.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fray3 embryonic cuticle biosynthesis (sensu
    Insecta) more
    54(a)   91B5   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y59A8B.233   -- 55(a)   V(17956707-17967938)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SKM16
    CLA46
    Member of the PAK family of serine/threonine prote...
    Cdc42p-activated signal transducing kinase of the ...
    17(a)
    13(a)
    many ↔ many
    many ↔ many
    XV(104326-106293) YOL113W
    XIV(68915-71443) YNL298W


    ENSEMBL Gene Tree for STK39 (if available)
    TreeFam Gene Tree for STK39 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for STK39 gene
    STRADB2  OXSR12  STRADA2  
    5 SIMAP similar genes for STK39 using alignment to 1 protein entry:     STK39_HUMAN:
    OXSR1    STK24    MST4    STK25    NEK7

    STK39 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STK39
    PGOHUM00000246061


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for STK39 (see all 6489)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75953101,2
    C,F,A,H--168810137(+) AGGAAG/ATGAGG 1 -- ds500122Minor allele frequency- A:0.46NS EA NA WA CSA 2344
    rs1466712261,2
    --168810229(+) CAGCAC/TTAAAA 1 -- ds50010--------
    rs1391614811,2
    --168810279(+) CTATAA/GCCCTA 1 -- ds50010--------
    rs76094341,2
    C,F,A,H--168810294(+) GGTTTT/AAATTC 1 -- ds500112Minor allele frequency- A:0.31NS EA WA NA CSA 787
    rs1888350151,2
    --168810452(+) TACTAA/GGCATT 1 -- ds50010--------
    rs1499071181,2
    C--168810634(+) GTATGC/TAAATG 1 -- ut310--------
    rs37694291,2
    H--168810739(-) TAGATA/GTGGCA 1 -- ut31 ese35Minor allele frequency- G:0.00EA NS 1912
    rs1997947761,2
    C--168810749(+) AGGGTC/TAGCTA 1 -- ut310--------
    rs2014620591,2
    C--168810754(+) TAGCTA/GGGAAA 1 -- ut310--------
    rs1817912351,2
    --168810774(+) TACCAC/TCCTGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for STK39 (168810530 - 169060530 bp, first 250kb of STK39)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STK39 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721098CNV Deletion23290073
    esv5404CNV Deletion18987735
    esv999027CNV Deletion20482838
    esv2214356CNV Deletion18987734
    esv2721096CNV Deletion23290073
    esv2665325CNV Deletion23128226
    esv1331913CNV Deletion17803354
    esv2668311CNV Deletion23128226
    esv2670762CNV Deletion23128226
    esv2721097CNV Deletion23290073

    Human Gene Mutation Database (HGMD): STK39
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STK39
    DNA2.0 Custom Variant and Variant Library Synthesis for STK39

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607648    OMIM disorders: --

    9 diseases for STK39:    About MalaCards
    pseudohypoaldosteronism    glanders    essential hypertension    hypertension
    b-cell lymphomas    parkinson's disease    prostate cancer    prostatitis
    lung cancer

    1 disease from the University of Copenhagen DISEASES database for STK39:
    Glanders

    STK39 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): STK39
    Human Genome Epidemiology (HuGE) Navigator: STK39 (10 documents)

    Export disorders for STK39 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for STK39 gene, integrated from 10 sources (see all 73):
    (articles sorted by number of sources associating them with STK39)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. (PubMed id 10980603)1, 2, 3 Johnston A.M....de Aizpurua H.J. (Oncogene 2000)
    2. From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene. (PubMed id 19114657)1, 4, 9 Wang Y....Chang Y.P. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    3. An analysis of candidate autism loci on chromosome 2q24-q33: evidence for association to the STK39 gene. (PubMed id 18348195)1, 4, 9 Ramoz N....Buxbaum J.D. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    4. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. (PubMed id 21292315)1, 4  ....Wood N.W. (Lancet 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Genome-wide analysis of survival in early-stage non-small-cell lung cancer. (PubMed id 19414679)1, 4 Huang Y.T....Christiani D.C. (J. Clin. Oncol. 2009)
    7. STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression. (PubMed id 20003416)1, 4 Cunnington M.S....Keavney B. (BMC Med. Genet. 2009)
    8. TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis. (PubMed id 16950202)1, 9 Polek T.C....Spivak-Kroizman T.R. (Biochem. Biophys. Res. Commun. 2006)
    9. PKCdelta acts upstream of SPAK in the activation of NKCC1 by hyperosmotic stress in human airway epithelial cells. (PubMed id 18550547)1, 9 Smith L....Liedtke C.M. (J. Biol. Chem. 2008)
    10. Cloning and characterization of a new intestinal inflammation- associated colonic epithelial Ste20-related protein kinase isoform. (PubMed id 17321610)1, 9 Yan Y.... Merlin D. (Biochim. Biophys. Acta 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 27347 HGNC: 17717 AceView: STK39 Ensembl:ENSG00000198648 euGenes: HUgn27347
    ECgene: STK39 H-InvDB: STK39

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for STK39 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for STK39 gene:
    Search GeneIP for patents involving STK39

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for STK39   OriGene RNAi products in human, mouse, rat for STK39  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for STK39  
     OriGene MassSpec something-or-other for STK39   OriGene clones in human, mouse for STK39  
     OriGene qSTAR qPCR primer pairs in human, mouse for STK39   OriGene Purified Protein for STK39  
     OriGene ORF clones in mouse, rat for STK39   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for STK39   OriGene Custom Protein Services for STK39  

     
     
     Block miRNA regulation of human, mouse, rat STK39 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing STK39
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK39 Predesigned siRNA for gene silencing in human, mouse, rat STK39
     QuantiFast Probe-based Assays in human, mouse, rat STK39 QuantiTect SYBR Green Assays in human, mouse, rat STK39
     Custom PCR Arrays for STK39 Search Chromatin IP Primers for STK39
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STK39  GeneGlobe Interaction Network for STK39
     Regulatory tfbs in STK39 promoter
     GenScript Custom Purified and Recombinant Proteins Services for STK39 GenScript cDNA clones with any tag delivered in your preferred vector for STK39
     GenScript Custom Assay Services for STK39 GenScript Custom overexpressing Cell Line Services for STK39
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for STK39  (STLK3)

     Search Tocris compounds for STK39
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     STK39 antibodies
     STK39 proteins
     STK39 lysates
     Antibodies for STK39
     See all of Abcam's Antibodies, Kits and Proteins for STK39
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for STK39
     Antibodies for STK39
     ELISAs for STK39
     CLIAs for STK39



     Browse ESI BIO Cell Lines and PureStem Progenitors for STK39
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK39
     SwitchGear 3'UTR luciferase reporter plasmids for STK39
     SwitchGear Promoter luciferase reporter plasmids for STK39
     ThermoFisher Antibody for STK39
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK39
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STK39
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STK39
     LSBio Antibodies in human, mouse, rat for STK39
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      STK39 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4