Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



STK38L Gene

protein-coding   GIFtS: 60
GCID: GC12P027396

Serine/Threonine Kinase 38 Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Serine/Threonine Kinase 38 Like1 2     EC 2.7.11.13 8
Nuclear Dbf2-Related 21 2     Serine/Threonine-Protein Kinase 38-Like2
Nuclear Dbf2-Related Kinase 22 3     KIAA09653
NDR22 3     EC 2.7.118
NDR2 Protein Kinase2 3     

External Ids:    HGNC: 178481   Entrez Gene: 230122   Ensembl: ENSG000002114557   UniProtKB: Q9Y2H13   

Export aliases for STK38L gene to outside databases

Previous GC identifers: GC12P027757 GC12P027408 GC12P027297 GC12P027288 GC12P027168


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for STK38L Gene:
STK38L (serine/threonine kinase 38 like) is a protein-coding gene. Diseases associated with STK38L include hiv-1, and neuronitis. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is CDC42BPG.

UniProtKB/Swiss-Prot: ST38L_HUMAN, Q9Y2H1
Function: Involved in the regulation of structural processes in differentiating and mature neuronal cells (By
similarity)

Gene Wiki entry for STK38L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STK38L gene promoter:
         AML1a   FOXD3   POU6F1 (c2)   GATA-2   GATA-1   Evi-1   FOXJ2 (long isoform)   FOXJ2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK38L promoter sequence
   Search Chromatin IP Primers for STK38L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK38L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.23   Ensembl cytogenetic band:  12p11.23   HGNC cytogenetic band: 12p11.22

STK38L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK38L gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P027396:  view genomic region     (about GC identifiers)

Start:
27,396,901 bp from pter      End:
27,478,892 bp from pter
Size:
81,992 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ST38L_HUMAN, Q9Y2H1 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 38-like  
Size: 464 amino acids; 54003 Da
Cofactor: Magnesium
Subunit: Homodimeric S100B binds two molecules of STK38L. Interacts with MICAL1; leading to inhibit the protein
kinase activity by antagonizing activation by MST1/STK4 (By similarity). Interacts with MOB1 and MOB2
Secondary accessions: A8K4U0 Q8TBX7

Explore the universe of human proteins at neXtProt for STK38L: NX_Q9Y2H1

Explore proteomics data for STK38L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys378
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for STK38L (Q9Y2H1) (see all 21)
     ETVLAID  CDWWSLG  KVIGRGAF  HRDIKPDN 


    See STK38L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055815.1  
    ENSEMBL proteins: 
     ENSP00000437856   ENSP00000373684   ENSP00000439457   ENSP00000445898   ENSP00000443838  
     ENSP00000443456   ENSP00000442253   ENSP00000440279   ENSP00000385174   ENSP00000443961  
     ENSP00000446386  

    STK38L Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for STK38L
    OriGene Protein Over-expression Lysate for STK38L
    OriGene MassSpec for STK38L
    OriGene Custom Protein Services for STK38L
    GenScript Custom Purified and Recombinant Proteins Services for STK38L
    Novus Biologicals STK38L Protein
    Novus Biologicals STK38L Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STK38L

    STK38L Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for STK38L
    OriGene Custom Antibody Services for STK38L
    Novus Biologicals STK38L Antibodies
    Abcam antibodies for STK38L
    Cloud-Clone Corp. Antibodies for STK38L
    ThermoFisher Antibodies for STK38L
    LSBio Antibodies in human, mouse, rat for STK38L

    STK38L Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STK38L
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STK38L
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STK38L
    Cloud-Clone Corp. CLIAs for STK38L


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: Serine/threonine kinase 38 like
    Other AGC kinases
    NDR family

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry Q9Y2H1

    ProtoNet protein and cluster: Q9Y2H1

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: ST38L_HUMAN, Q9Y2H1
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    STK38L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST38L_HUMAN, Q9Y2H1
    Function: Involved in the regulation of structural processes in differentiating and mature neuronal cells (By
    similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP
    to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by
    STK24/MST3. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that
    complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and
    MOB2/HCCA2 to the N-terminal of STK38L

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA15067004
    GO:0003779actin binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA15037617
    GO:0004713protein tyrosine kinase activity ----
         
    STK38L for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for STK38L:
     Decreased Wnt reporter activit  Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability 
     Increased cell number in G1, a  Increased cilium length after  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STK38L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STK38L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STK38L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STK38L

    miRNA
    Products:
        
    miRTarBase miRNAs that target STK38L:
    hsa-mir-130a-3p (MIRT045849), hsa-mir-124-3p (MIRT022750), hsa-mir-375 (MIRT019964)

    Block miRNA regulation of human, mouse, rat STK38L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK38L (see all 116):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-520e hsa-miR-300 hsa-miR-15a hsa-miR-128 hsa-miR-4305 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidSTK38L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STK38L
    Predesigned siRNA for gene silencing in human, mouse, rat STK38L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STK38L

    Clone
    Products:
         
    OriGene clones in human, mouse for STK38L (see all 7)
    OriGene ORF clones in mouse, rat for STK38L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STK38L (NM_015000)
    Sino Biological Human cDNA Clone for STK38L
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STK38L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK38L

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STK38L
    Browse ESI BIO Cell Lines and PureStem Progenitors for STK38L 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK38L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ST38L_HUMAN, Q9Y2H1: Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Note=Associated with the actin cytoskeleton.
    Co-localizes with STK24/MST3 in the membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus4
    plasma membrane4
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA15037617
    GO:0005886plasma membrane ----
    GO:0015629actin cytoskeleton ISS--
    GO:0016020membrane IEA--

    STK38L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STK38L
    Interactions:

        GeneGlobe Interaction Network for STK38L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STK38L (Q9Y2H11, 2, 3 ENSP000003736844) via UniProtKB, MINT, STRING, and/or I2D (see all 141)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MOB1AQ9H8S91, 3, ENSP000003793644EBI-991501,EBI-748229 I2D: score=8 STRING: ENSP00000379364
    YWHABP319462, 3, ENSP000003001614MINT-50986 I2D: score=3 STRING: ENSP00000300161
    CDC14AQ9UNH53, ENSP000003549164I2D: score=3 STRING: ENSP00000354916
    PAK3O759143, ENSP000003538644I2D: score=3 STRING: ENSP00000353864
    KRT31Q153233, ENSP000002516454I2D: score=2 STRING: ENSP00000251645
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA15037617
    GO:0035556intracellular signal transduction IDA15067004
    GO:0051128regulation of cellular component organization ISS--

    STK38L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STK38L (ST38L)

    4 HMDB Compounds for STK38L    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for STK38L gene: 
    NM_015000.3  

    Unigene Cluster for STK38L:

    Serine/threonine kinase 38 like
    Hs.184523  [show with all ESTs]
    Unigene Representative Sequence: AB023182
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541191 ENST00000389032(uc001rhr.3 uc010sjm.2 uc010sjn.2 uc010sjo.2)
    ENST00000545470 ENST00000544367 ENST00000539863 ENST00000434385 ENST00000540996
    ENST00000546286 ENST00000543246 ENST00000544969 ENST00000407753 ENST00000536093
    ENST00000543992 ENST00000539577
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STK38L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK38L (see all 116):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-520e hsa-miR-300 hsa-miR-15a hsa-miR-128 hsa-miR-4305 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidSTK38L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STK38L
    Predesigned siRNA for gene silencing in human, mouse, rat STK38L
    Clone
    Products:
         
    OriGene clones in human, mouse for STK38L (see all 7)
    OriGene ORF clones in mouse, rat for STK38L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STK38L (NM_015000)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STK38L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK38L
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STK38L
    OriGene qSTAR qPCR primer pairs in human, mouse for STK38L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STK38L
      QuantiTect SYBR Green Assays in human, mouse, rat STK38L
      QuantiFast Probe-based Assays in human, mouse, rat STK38L

    Additional mRNA sequence: 

    AB023182.2 AK291055.1 AK303373.1 AK304755.1 AK304862.1 BC014782.1 BC028603.1 

    12 DOTS entries:

    DT.448623  DT.121159034  DT.121159012  DT.100657310  DT.100717355  DT.102822551  DT.121159038  DT.318021 
    DT.91966422  DT.92427145  DT.99946788  DT.91709952 

    Selected AceView cDNA sequences (see all 205):

    AA236280 AA804404 BX399279 BG222848 AI640444 AI923472 CB216368 AW235748 
    AI868442 AI273760 AI758581 AA455607 AA626426 BC014782 BX362220 AA278970 
    AI913076 CA413301 CD101704 BF594412 AI798077 N54725 AW779556 BM800189 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    STK38L expression in normal human tissues (normalized intensities)      STK38L embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCAAATTA
    STK38L Expression
    About this image


    STK38L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Chondrocyte-like cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Chondrocyte-like cells
     
     Heart (Cardiovascular System)
             Cushion Mesenchymal Cells Endocardium
    STK38L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STK38L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.184523

    UniProtKB/Swiss-Prot: ST38L_HUMAN, Q9Y2H1
    Tissue specificity: Ubiquitously expressed with highest levels observed in the thymus

        Custom PCR Arrays for STK38L
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for STK38L
    OriGene qSTAR qPCR primer pairs in human, mouse for STK38L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STK38L
    QuantiTect SYBR Green Assays in human, mouse, rat STK38L
    QuantiFast Probe-based Assays in human, mouse, rat STK38L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK38L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STK38L gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk38l1 , 5 serine/threonine kinase 38 like1, 5 89.65(n)1
    97.8(a)1
      6 (77.70 cM)5
    2325331  NM_172734.31  NP_766322.11 
     1467249955 
    chicken
    (Gallus gallus)
    Aves STK38L1 serine/threonine kinase 38 like 83.83(n)
    93.53(a)
      418217  NM_001030770.2  NP_001025941.2 
    lizard
    (Anolis carolinensis)
    Reptilia STK38L6
    serine/threonine kinase 38 like
    96(a)
    1 ↔ 1
    5(91261912-91320408)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.118902 Transcribed sequence with moderate similarity to protein more 78.55(n)    CF219013.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stk38l1 serine/threonine kinase 38 like 76.4(n)
    91.15(a)
      393957  NM_200982.1  NP_957276.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta trc3 protein amino acid phosphorylation
    protein serine/threonine more
    69(a)   3 76D1   --
    worm
    (Caenorhabditis elegans)
    Secernentea sax-11 , 3 Expression: muscle, seam cells,
    hypodermal, nerve more3
    sax-11
    67(a)3
    62.2(n)1
    67.5(a)1
      X(3676040-3677189)3
    1806551  NM_076226.51  NP_508627.51 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CBK11 CBK1 57.56(n)
    52.14(a)
      855561   NP_014238.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G330801 AT4G33080 56.37(n)
    49.77(a)
      829445  NM_119462.3  NP_195034.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g01867001 Os01g0186700 56.78(n)
    50.34(a)
      4325661  NM_001048781.1  NP_001042246.1 


    ENSEMBL Gene Tree for STK38L (if available)
    TreeFam Gene Tree for STK38L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for STK38L gene
    CDC42BPG2  DMPK2  LATS12  CDC42BPB2  STK382  MASTL2  CIT2  ROCK12  
    CDC42BPA2  LATS22  ROCK22  
    Selected SIMAP similar genes for STK38L using alignment to 9 protein entries:     ST38L_HUMAN (see all proteins) (see all similar genes):
    STK38    SGK494    KIN27    CAMKK2    STK11    MAST1
    RPS6KA5    SGK2    STK32A    PHKG2    PRKACA    CDK1
    LATS1    PKMYT1    PRKCZ    AKT2    DMPK    RPS6KA2

    STK38L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for STK38L (see all 1502)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503244941,2
    C--27395086(+) CCACAA/GATATT 1 -- us2k10--------
    rs759991961,2
    C,F--27395166(+) GTTTTA/TCAAGG 1 -- us2k11Minor allele frequency- T:0.06NA 120
    rs1378767001,2
    --27395310(+) CCTTGG/TTGGCT 1 -- us2k10--------
    rs800683761,2
    C,F--27395489(+) TTGCTA/GTATTT 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs1815330631,2
    --27395564(+) ATCATC/TGGCAG 1 -- us2k10--------
    rs584811811,2
    C,F--27395657(+) TATCAA/GTTTCC 1 -- us2k13Minor allele frequency- G:0.11WA CSA 122
    rs579604511,2
    --27395718(+) GTCCAC/TAGACC 1 -- us2k10--------
    rs1389572891,2
    C--27395808(+) GGTCTC/TAATTT 1 -- us2k10--------
    rs1865471881,2
    --27395854(+) CTATCC/GCATAT 1 -- us2k10--------
    rs1428034881,2
    --27396027(+) TCAAGA/CTTGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for STK38L (27396901 - 27478892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STK38L (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv997751CNV Deletion20482838
    esv2745667CNV Deletion23290073
    esv2395169CNV Deletion18987734
    esv2745664CNV Deletion23290073
    esv4652CNV Deletion18987735
    esv2598897CNV Deletion19546169
    esv2672021CNV Deletion23128226
    esv996338CNV Deletion20482838
    dgv271e199CNV Deletion23128226
    esv2667338CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STK38L
    DNA2.0 Custom Variant and Variant Library Synthesis for STK38L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    3 diseases for STK38L:    About MalaCards
    hiv-1    neuronitis    malaria


    STK38L for disorders           About GeneDecksing

    Genetic Association Database (GAD): STK38L
    Human Genome Epidemiology (HuGE) Navigator: STK38L (1 document)

    Export disorders for STK38L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for STK38L gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with STK38L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein. (PubMed id 15037617)1, 2, 9 Stegert M.R....Hemmings B.A. (J. Biol. Chem. 2004)
    2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    3. NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling. (PubMed id 16488889)1, 3 Suzuki A.... Esumi H. (J. Biol. Chem. 2006)
    4. Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3. (PubMed id 16314523)1, 2 Stegert M.R....Hemmings B.A. (Mol. Cell. Biol. 2005)
    5. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. (PubMed id 15067004)1, 2 Devroe E.... Silver P.A. (J. Biol. Chem. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    8. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    9. HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases. (PubMed id 15582665)1, 9 Devroe E....Engelman A. (Virology 2005)
    10. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23012 HGNC: 17848 AceView: STK38L Ensembl:ENSG00000211455 euGenes: HUgn23012
    ECgene: STK38L H-InvDB: STK38L

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0965

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for STK38L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for STK38L gene:
    Search GeneIP for patents involving STK38L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for STK38L   OriGene RNAi products in human, mouse, rat for STK38L  
     OriGene qPCR primer pairs and template standards for STK38L   OriGene Protein Over-expression Lysate for STK38L  
     OriGene MassSpec something-or-other for STK38L   OriGene clones in human, mouse for STK38L  
     OriGene qSTAR qPCR primer pairs in human, mouse for STK38L   OriGene Purified Protein for STK38L  
     OriGene ORF clones in mouse, rat for STK38L   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for STK38L   OriGene Custom Protein Services for STK38L  

     
     
     Block miRNA regulation of human, mouse, rat STK38L using miScript Target Protectors SeqTarget long-range PCR primers for resequencing STK38L
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK38L Predesigned siRNA for gene silencing in human, mouse, rat STK38L
     QuantiFast Probe-based Assays in human, mouse, rat STK38L QuantiTect SYBR Green Assays in human, mouse, rat STK38L
     Custom PCR Arrays for STK38L Search Chromatin IP Primers for STK38L
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STK38L  GeneGlobe Interaction Network for STK38L
     Regulatory tfbs in STK38L promoter
     GenScript Custom Purified and Recombinant Proteins Services for STK38L GenScript cDNA clones with any tag delivered in your preferred vector for STK38L
     GenScript Custom Assay Services for STK38L GenScript Custom overexpressing Cell Line Services for STK38L
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for STK38L (ST38L)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for STK38L
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     STK38L antibodies
     STK38L proteins
     STK38L lysates
     Antibodies for STK38L
     See all of Abcam's Antibodies, Kits and Proteins for STK38L
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for STK38L
     Antibodies for STK38L
     ELISAs for STK38L
     CLIAs for STK38L



     Browse ESI BIO Cell Lines and PureStem Progenitors for STK38L
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK38L
     SwitchGear 3'UTR luciferase reporter plasmids for STK38L
     SwitchGear Promoter luciferase reporter plasmids for STK38L
     ThermoFisher Antibodies for STK38L
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK38L
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STK38L
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STK38L
     LSBio Antibodies in human, mouse, rat for STK38L
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      STK38L gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4