STK38L Gene
protein-coding GIFtS: 55
GCID: GC12P027396
|
|
serine/threonine kinase 38 like
| |
Aliases
for STK38L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine/Threonine Kinase 38 Like1 2 | | EC 2.7.11.13 8 | | NDR21 2 3 | | Nuclear Dbf2-Related 22 | | KIAA09651 3 | | Serine/Threonine-Protein Kinase 38-Like2 | | Nuclear Dbf2-Related Kinase 22 3 | | EC 2.7.118 | | NDR2 Protein Kinase2 3 | | |
Export aliases for STK38L gene to outside databasesPrevious GC identifers: GC12P027757 GC12P027408 GC12P027297 GC12P027288 GC12P027168 |
Summaries
for STK38L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ST38L_HUMAN, Q9Y2H1Function: Involved in the regulation of structural processes in differentiating and mature neuronal cells (Bysimilarity)
Gene Wiki entry for STK38L
|
Genomic Views
for STK38L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STK38L gene promoter:
AML1a FOXD3 POU6F1 (c2) GATA-2 GATA-1 Evi-1 FOXJ2 (long isoform) FOXJ2 LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for STK38L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK38L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p11.23 Ensembl cytogenetic band: 12p11.23 HGNC cytogenetic band: 12p11.22STK38L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P027396: view genomic region
(about GC identifiers)
Start:
|
27,396,901 bp from pter |
End:
|
27,478,892 bp from pter |
Size:
|
81,992 bases |
Orientation:
|
plus strand |
|
Proteins
for STK38L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ST38L_HUMAN, Q9Y2H1 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase 38-like Size: 464 amino acids; 54003 Da
Cofactor: Magnesium
Subunit: Homodimeric S100B binds two molecules of STK38L. Interacts with MICAL1; leading to inhibit the protein kinaseactivity by antagonizing activation by MST1/STK4 (By similarity). Interacts with MOB1 and MOB2
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Note=Associated with the actin cytoskeleton.Co-localizes with STK24/MST3 in the membrane
Secondary accessions: A8K4U0 Q8TBX7Explore the universe of human proteins at neXtProt for STK38L: NX_Q9Y2H1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2H1
4/21 DME Specific Peptides for STK38L (Q9Y2H1) (see all 21)
STK38L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055815.1
ENSEMBL proteins: ENSP00000437856 ENSP00000373684 ENSP00000439457 ENSP00000445898 ENSP00000443838 ENSP00000443456 ENSP00000442253 ENSP00000440279 ENSP00000385174 ENSP00000443961 ENSP00000446386
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
STK38L for ontologies About GeneDecksing
STK38L Antibody Products:
Assay Products for STK38L: |
Protein
Domains /
Families
for STK38L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STK38L for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9Y2H1ProtoNet protein and cluster: Q9Y2H1 1 Blocks protein family: IPB000961 Protein kinase C-terminal domain
UniProtKB/Swiss-Prot: ST38L_HUMAN, Q9Y2H1Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase familySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 1 protein kinase domain |
Function
for STK38L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ST38L_HUMAN, Q9Y2H1Function: Involved in the regulation of structural processes in differentiating and mature neuronal cells (Bysimilarity)Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP tobind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by STK24/MST3.Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete theactivation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to theN-terminal of STK38LEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK38L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK38L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK38L |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
STK38L for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for STK38L:
|
Pathways & Interactions
for STK38L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STK38L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/49 Interacting proteins for STK38L (Q9Y2H12, 3 ENSP000003736844) via UniProtKB, MINT, STRING, and/or I2D (see all 49)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
STK38L for ontologies About GeneDecksing
|
Drugs & Compounds
for STK38L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STK38L
4 HMDB Compounds for STK38L About this table
Search CenterWatch for drugs/clinical trials and news about STK38L / ST38L
|
Transcripts
for STK38L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STK38L gene: NM_015000.3 Unigene Cluster for STK38L: Serine/threonine kinase 38 like Hs.184523 [show with all ESTs]Unigene Representative Sequence: AB02318214 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000541191 ENST00000389032(uc001rhr.3 uc010sjm.2 uc010sjn.2 uc010sjo.2)
ENST00000545470 ENST00000544367 ENST00000539863 ENST00000434385 ENST00000540996
ENST00000546286 ENST00000543246 ENST00000544969 ENST00000407753 ENST00000536093
ENST00000543992 ENST00000539577
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK38L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK38L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AB023182.2 AK291055.1 AK303373.1 AK304755.1 AK304862.1 BC014782.1 BC028603.1 12 DOTS entries: DT.448623 DT.121159034 DT.121159012 DT.100657310 DT.100717355 DT.102822551 DT.121159038 DT.318021 DT.91966422 DT.92427145 DT.99946788 DT.91709952 24/205 AceView cDNA sequences (see all 205): AL600107 AI468533 AA453905 AI798077 BF594412 CD101704 CA413301 BC014782 AI640444 AI923472 AA626426 AA455607 AA804404 AI758581 AA502634 H27994 AA278311 AI278564 BM795251 AA456103 AI913076 BX362219 AW779556 BX399279
GeneLoc Exon Structure
|
Expression
for STK38L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STK38L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGCAAATTA
About this image
See STK38L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STK38L
SOURCE GeneReport for Unigene cluster: Hs.184523
UniProtKB/Swiss-Prot: ST38L_HUMAN, Q9Y2H1Tissue specificity: Ubiquitously expressed with highest levels observed in the thymus
SABiosciences Custom PCR Arrays for STK38L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STK38L
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK38L |
Orthologs
for STK38L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for STK38L gene from 9/35 species (see all 35) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
STK38L1 |
serine/threonine kinase 38 like |
84.24(n)
94.09(a) |
|
418217 NM_001030770.2 NP_001025941.2 |
lizard
(Anolis carolinensis) |
Reptilia |
STK38L6 |
-- |
96(a) |
1 ↔ 1 |
5(91288900-91316690) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.118902 |
Transcribed sequence with moderate similarity to protein more |
78.55(n) |
|
CF219013.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
stk38l1 |
serine/threonine kinase 38 like |
76.26(n)
90.26(a) |
|
393957 NM_200982.1 NP_957276.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
trc1 , 3 |
protein amino acid phosphorylation protein
serine/threonine more3
tricornered1 |
69(a)3
62.14(n)1
71.89(a)1 |
|
3 76D13
401651 NM_079446.31 NP_524170.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
sax-11 , 3 |
Expression: muscle, seam cells, hypodermal,
nerve more3
Protein SAX-11 |
67(a)3
62.2(n)1
67.5(a)1 |
|
X(3676040-3677189)3
1806551 NM_001029687.21 NP_001024858.21 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
CBK11 |
Cbk1p |
57.56(n)
52.14(a) |
|
855561 NP_014238.3 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G306401 |
Protein kinase family protein |
55.69(n)
50.23(a) |
|
839944 NM_102801.2 NP_174352.1 |
rice
(Oryza sativa) |
Liliopsida |
Os05g05114001 |
hypothetical protein |
56.53(n)
51.38(a) |
|
4339288 NM_001062550.1 NP_001056015.1 |
ENSEMBL Gene Tree for STK38L (if available)
TreeFam Gene Tree for STK38L (if available) |
Paralogs
for STK38L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STK38L gene
- CDC42BPG2 DMPK2 LATS12 CDC42BPB2 STK382 CIT2 ROCK12 CDC42BPA2
- LATS22 ROCK22
18/71 SIMAP similar genes for STK38L using alignment to 9 protein entries: ST38L_HUMAN (see all proteins)
(see all similar genes):STK38 SGK494 MAP2K4 AKT2 KIN27 CAMKK2
STK11 MAST1 RPS6KA5 SGK2 STK32A PHKG2
PRKACA LATS1 RPS6KA2 HUNK PHKG1 PKN1
STK38L for paralogs About GeneDecksing
|
Genomic Variants
for STK38L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STK38L (27396901 - 27478892 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for STK38L
1 CNV: 101464
5 Indels: 42663 39892 45029 61217 24988 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STK38L |
|
Disorders
/ Diseases
for STK38L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STK38L for disorders About GeneDecksing
1  disease for STK38L: About MalaCardsneuronitis
Human Genome Epidemiology (HuGE) Navigator: STK38L (1 document)
Export disorders for STK38L gene to outside databases
|
Publications
for STK38L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STK38L gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with STK38L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein. (PubMed id 15037617)1, 2, 9 Stegert M.R....Hemmings B.A. (2004)
- NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling. (PubMed id 16488889)1, 3 Suzuki A....Esumi H. (2006)
- Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3. (PubMed id 16314523)1, 2 Stegert M.R....Hemmings B.A. (2005)
- Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. (PubMed id 15067004)1, 2 Devroe E.... Silver P.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
- HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases. (PubMed id 15582665)1, 9 Devroe E....Engelman A. (2005)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Human NDR kinases control G(1)/S cell cycle transitio n by directly regulating p21 stability. (PubMed id 21262772)1 Cornils H....Hemmings B.A. (2011)
|
External Searches for STK38L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STK38L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STK38L gene
(According to HUGE)
About This Section
| |
Specialized Databases showing STK38L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STK38L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STK38L gene:
Search GeneIP for patents involving STK38L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STK38L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK38L |
|  |  |  | | | | ThermoFisher Antibodies for STK38L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK38L |
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