Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STK38L Gene

Aliases for STK38L Gene

  • Serine/Threonine Kinase 38 Like 2 3 5
  • Nuclear Dbf2-Related Kinase 2 3 4
  • Nuclear Dbf2-Related 2 2 3
  • NDR2 Protein Kinase 3 4
  • EC 4 63
  • NDR2 3 4
  • EC 2.7.11 63
  • KIAA0965 4

External Ids for STK38L Gene

Previous GeneCards Identifiers for STK38L Gene

  • GC12P027757
  • GC12P027408
  • GC12P027297
  • GC12P027288
  • GC12P027168
  • GC12P027396

Summaries for STK38L Gene

GeneCards Summary for STK38L Gene

STK38L (Serine/Threonine Kinase 38 Like) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDC42BPA.

UniProtKB/Swiss-Prot for STK38L Gene

  • Involved in the regulation of structural processes in differentiating and mature neuronal cells.

Gene Wiki entry for STK38L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK38L Gene

Genomics for STK38L Gene

Regulatory Elements for STK38L Gene

Enhancers for STK38L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STK38L on UCSC Golden Path with GeneCards custom track

Promoters for STK38L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STK38L on UCSC Golden Path with GeneCards custom track

Genomic Location for STK38L Gene

27,243,968 bp from pter
27,325,959 bp from pter
81,992 bases
Plus strand

Genomic View for STK38L Gene

Genes around STK38L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK38L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK38L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK38L Gene

Proteins for STK38L Gene

  • Protein details for STK38L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase 38-like
    Protein Accession:
    Secondary Accessions:
    • A8K4U0
    • B4E3J8
    • Q8TBX7

    Protein attributes for STK38L Gene

    464 amino acids
    Molecular mass:
    54003 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimeric S100B binds two molecules of STK38L. Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (By similarity). Interacts with MOB1 and MOB2.

    Alternative splice isoforms for STK38L Gene


neXtProt entry for STK38L Gene

Proteomics data for STK38L Gene at MOPED

Post-translational modifications for STK38L Gene

  • Ubiquitination at Lys 378
  • Modification sites at PhosphoSitePlus

Domains & Families for STK38L Gene

Suggested Antigen Peptide Sequences for STK38L Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK38L: view

Function for STK38L Gene

Molecular function for STK38L Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L.
UniProtKB/Swiss-Prot Function:
Involved in the regulation of structural processes in differentiating and mature neuronal cells.

Enzyme Numbers (IUBMB) for STK38L Gene

Gene Ontology (GO) - Molecular Function for STK38L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 15067004
GO:0003779 actin binding IEA --
GO:0005524 ATP binding IEA,IDA 15067004
genes like me logo Genes that share ontologies with STK38L: view
genes like me logo Genes that share phenotypes with STK38L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STK38L

CRISPR Products

miRNA for STK38L Gene

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK38L Gene

Localization for STK38L Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK38L Gene

Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Note=Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.

Subcellular locations from

Jensen Localization Image for STK38L Gene COMPARTMENTS Subcellular localization image for STK38L gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for STK38L Gene

Pathways & Interactions for STK38L Gene

SuperPathways for STK38L Gene

No Data Available

SIGNOR curated interactions for STK38L Gene

Is activated by:

Gene Ontology (GO) - Biological Process for STK38L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 15037617
genes like me logo Genes that share ontologies with STK38L: view

No data available for Pathways by source for STK38L Gene

Drugs & Compounds for STK38L Gene

(3) Drugs for STK38L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
calcium Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for STK38L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK38L: view

Transcripts for STK38L Gene

Unigene Clusters for STK38L Gene

Serine/threonine kinase 38 like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK38L Gene

No ASD Table

Relevant External Links for STK38L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STK38L Gene

mRNA expression in normal human tissues for STK38L Gene

mRNA differential expression in normal tissues according to GTEx for STK38L Gene

This gene is overexpressed in Artery - Aorta (x5.0) and Artery - Tibial (x4.4).

Protein differential expression in normal tissues from HIPED for STK38L Gene

This gene is overexpressed in Lymph node (10.3) and Frontal cortex (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STK38L Gene

SOURCE GeneReport for Unigene cluster for STK38L Gene Hs.184523

mRNA Expression by UniProt/SwissProt for STK38L Gene

Tissue specificity: Ubiquitously expressed with highest levels observed in the thymus.
genes like me logo Genes that share expression patterns with STK38L: view

Protein tissue co-expression partners for STK38L Gene

- Elite partner

Primer Products

Orthologs for STK38L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK38L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STK38L 35
  • 95.26 (n)
  • 99.14 (a)
STK38L 36
  • 99 (a)
(Canis familiaris)
Mammalia STK38L 35
  • 94.83 (n)
  • 99.14 (a)
STK38L 36
  • 99 (a)
(Mus musculus)
Mammalia Stk38l 35
  • 89.65 (n)
  • 97.8 (a)
Stk38l 16
Stk38l 36
  • 98 (a)
(Pan troglodytes)
Mammalia STK38L 35
  • 99.64 (n)
  • 100 (a)
STK38L 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Stk38l 35
  • 88.18 (n)
  • 97.8 (a)
(Monodelphis domestica)
Mammalia STK38L 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia STK38L 36
  • 91 (a)
(Gallus gallus)
Aves STK38L 35
  • 83.83 (n)
  • 93.53 (a)
STK38L 36
  • 88 (a)
(Anolis carolinensis)
Reptilia STK38L 36
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stk38l 35
  • 77.63 (n)
  • 94.92 (a)
Str.11890 35
(Danio rerio)
Actinopterygii stk38l 35
  • 76.4 (n)
  • 91.15 (a)
stk38l 36
  • 90 (a)
fruit fly
(Drosophila melanogaster)
Insecta trc 37
  • 69 (a)
trc 36
  • 68 (a)
(Caenorhabditis elegans)
Secernentea sax-1 37
  • 67 (a)
sax-1 35
  • 62.2 (n)
  • 67.5 (a)
sax-1 36
  • 63 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR035W 35
  • 55.3 (n)
  • 53.27 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D07810g 35
  • 57.86 (n)
  • 52.82 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CBK1 35
  • 57.56 (n)
  • 52.14 (a)
CBK1 36
  • 31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G33080 35
  • 56.37 (n)
  • 49.77 (a)
(Hordeum vulgare)
Liliopsida Hv.1876 35
(Oryza sativa)
Liliopsida Os01g0186700 35
  • 56.78 (n)
  • 50.34 (a)
(Triticum aestivum)
Liliopsida Ta.6269 35
(Zea mays)
Liliopsida Zm.5558 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1672 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07296 35
  • 51.62 (n)
  • 45.13 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes orb6 35
  • 55.91 (n)
  • 51.69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
Species with no ortholog for STK38L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for STK38L Gene

Gene Tree for STK38L (if available)
Gene Tree for STK38L (if available)

Paralogs for STK38L Gene

Paralogs for STK38L Gene

genes like me logo Genes that share paralogs with STK38L: view

Variants for STK38L Gene

Sequence variations from dbSNP and Humsavar for STK38L Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_041199 -
rs1963511 -- 27,263,349(+) AGCAG(G/T)TCTTT intron-variant
rs1963512 -- 27,263,365(+) TATTA(C/T)ACTTC intron-variant
rs2029092 -- 27,259,322(+) CAGCA(A/G)AATTC intron-variant
rs2029093 -- 27,259,693(+) CCAAC(A/G)TACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK38L Gene

Variant ID Type Subtype PubMed ID
esv2745664 CNV Deletion 23290073
nsv832356 CNV Gain 17160897
dgv271e199 CNV Deletion 23128226
nsv521872 CNV Gain 19592680
nsv898940 CNV Loss 21882294
nsv436825 CNV Insertion 17901297
esv2672021 CNV Deletion 23128226
esv997751 CNV Deletion 20482838
esv2598897 CNV Deletion 19546169
esv2395169 CNV Deletion 18987734
esv4652 CNV Deletion 18987735
esv2745667 CNV Deletion 23290073
esv996338 CNV Deletion 20482838
esv7285 CNV Loss 19470904
esv1525868 CNV Deletion 17803354
nsv469175 CNV Loss 19166990
esv2667338 CNV Deletion 23128226

Variation tolerance for STK38L Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK38L Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK38L Gene

Disorders for STK38L Gene

Relevant External Links for STK38L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STK38L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK38L Gene

Publications for STK38L Gene

  1. Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein. (PMID: 15037617) Stegert M.R. … Hemmings B.A. (J. Biol. Chem. 2004) 3 4 23 67
  2. NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling. (PMID: 16488889) Suzuki A. … Esumi H. (J. Biol. Chem. 2006) 2 3
  3. HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases. (PMID: 15582665) Devroe E. … Engelman A. (Virology 2005) 3 23
  4. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 3
  5. Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. (PMID: 25670202) Rashidian J. … Luo K. (Sci Signal 2015) 3

Products for STK38L Gene

Sources for STK38L Gene