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Aliases for STK38 Gene

Aliases for STK38 Gene

  • Serine/Threonine Kinase 38 2 3 5
  • Nuclear Dbf2-Related Kinase 1 3 4
  • NDR1 Protein Kinase 3 4
  • EC 4 58
  • NDR1 3 4
  • Serine/Threonine-Protein Kinase 38 3
  • Ndr Ser/Thr Kinase-Like Protein 3
  • EC 2.7.11 58
  • NDR 3

External Ids for STK38 Gene

Previous GeneCards Identifiers for STK38 Gene

  • GC06M036463
  • GC06M036508
  • GC06M036569
  • GC06M036461
  • GC06M036180

Summaries for STK38 Gene

Entrez Gene Summary for STK38 Gene

  • This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for STK38 Gene

STK38 (Serine/Threonine Kinase 38) is a Protein Coding gene. Among its related pathways are Interactome of polycomb repressive complex 2 (PRC2) and Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK38L.

UniProtKB/Swiss-Prot for STK38 Gene

  • Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.

Gene Wiki entry for STK38 Gene

Additional gene information for STK38 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK38 Gene

Genomics for STK38 Gene

Regulatory Elements for STK38 Gene

Enhancers for STK38 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H036592 3 FANTOM5 Ensembl ENCODE dbSUPER 20.7 -49.9 -49940 10.7 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A SRSF3 KCTD20 CDKN1A LAP3P2 RAB44 STK38 ENSG00000237719 FKBP5 BRPF3 RNU1-88P
GH06H037201 1.3 ENCODE dbSUPER 29.2 -656.1 -656112 3.6 HDGF PKNOX1 FOXA2 ARNT YBX1 FEZF1 ZNF207 FOS MCM3 MCM5 SRSF3 STK38 PIM1 TBC1D22B CMTR1 CDKN1A RAB44 COX6A1P2 PIR49359
GH06H035723 1.8 FANTOM5 ENCODE dbSUPER 20.6 +818.4 818382 10.8 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 MCM3 NFYC ZC3H11A TAF11 SRSF3 ENSG00000272374 ZNF76 RPL10A STK38 ENSG00000219023 FANCE PPARD ENSG00000228559
GH06H036675 1.5 ENCODE dbSUPER 20.8 -133.4 -133371 10.4 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 SRSF3 CMTR1 RNU1-88P C6orf89 STK38 RNF8 LAP3P2 MAPK14 RN7SL502P ARMC12
GH06H036422 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +124.0 123950 2 MLX ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF207 FOS DEK ETV7 KCTD20 LOC105375037 C6orf222 STK38 PI16 MAPK13 PXT1 SRSF3 CDKN1A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STK38 on UCSC Golden Path with GeneCards custom track

Promoters for STK38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000196215 1079 2401 HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF207 ZNF143

Genomic Locations for STK38 Gene

Genomic Locations for STK38 Gene
53,591 bases
Minus strand

Genomic View for STK38 Gene

Genes around STK38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK38 Gene

Proteins for STK38 Gene

  • Protein details for STK38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase 38
    Protein Accession:
    Secondary Accessions:
    • Q503A1

    Protein attributes for STK38 Gene

    465 amino acids
    Molecular mass:
    54190 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (By similarity). Homodimeric S100B binds two molecules of STK38. Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with MOB1 and MOB2. Interacts with MAP3K1 and MAP3K2 (via the kinase catalytic domain). Forms a tripartite complex with MOBKL1B and STK3/MST2.

    Three dimensional structures from OCA and Proteopedia for STK38 Gene

neXtProt entry for STK38 Gene

Selected DME Specific Peptides for STK38 Gene


Post-translational modifications for STK38 Gene

Other Protein References for STK38 Gene

Domains & Families for STK38 Gene

Gene Families for STK38 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for STK38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK38: view

Function for STK38 Gene

Molecular function for STK38 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38.
UniProtKB/Swiss-Prot Function:
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.

Enzyme Numbers (IUBMB) for STK38 Gene

Phenotypes From GWAS Catalog for STK38 Gene

Gene Ontology (GO) - Molecular Function for STK38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 12493777
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA 12493777
GO:0005515 protein binding IPI 9774336
GO:0005524 ATP binding IDA 12493777
genes like me logo Genes that share ontologies with STK38: view
genes like me logo Genes that share phenotypes with STK38: view

Animal Models for STK38 Gene

MGI Knock Outs for STK38:

miRNA for STK38 Gene

miRTarBase miRNAs that target STK38

Clone Products

  • Addgene plasmids for STK38

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK38 Gene

Localization for STK38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK38 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK38 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STK38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12493777
GO:0005737 cytoplasm IDA,IEA 17906693
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with STK38: view

Pathways & Interactions for STK38 Gene

genes like me logo Genes that share pathways with STK38: view

Pathways by source for STK38 Gene

1 BioSystems pathway for STK38 Gene
1 Qiagen pathway for STK38 Gene

SIGNOR curated interactions for STK38 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for STK38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IDA 7761441
GO:0006468 protein phosphorylation IDA 12493777
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
GO:0035556 intracellular signal transduction IDA 12493777
genes like me logo Genes that share ontologies with STK38: view

Drugs & Compounds for STK38 Gene

(3) Drugs for STK38 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Nutra Agonist 0
calcium Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for STK38 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK38: view

Transcripts for STK38 Gene

Unigene Clusters for STK38 Gene

Serine/threonine kinase 38:
Representative Sequences:

Clone Products

  • Addgene plasmids for STK38

Alternative Splicing Database (ASD) splice patterns (SP) for STK38 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d
SP1: - - - -
SP2: - - - -
SP3: - - -
SP5: - - -
SP6: -

Relevant External Links for STK38 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STK38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STK38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK38 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for STK38 Gene

This gene is overexpressed in Lymph node (16.4), Peripheral blood mononuclear cells (14.0), and CD8 Tcells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STK38 Gene

Protein tissue co-expression partners for STK38 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STK38 Gene:


SOURCE GeneReport for Unigene cluster for STK38 Gene:


mRNA Expression by UniProt/SwissProt for STK38 Gene:

Tissue specificity: Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for STK38 Gene

  • Nervous system(2.4)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with STK38: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STK38 Gene

Orthologs for STK38 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK38 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STK38 34 33
  • 99.93 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 99 (a)
-- 34
  • 88 (a)
(Bos Taurus)
Mammalia STK38 33 34
  • 96.85 (n)
(Canis familiaris)
Mammalia STK38 34 33
  • 96.34 (n)
(Mus musculus)
Mammalia Stk38 33 16 34
  • 92.76 (n)
(Ornithorhynchus anatinus)
Mammalia STK38 34
  • 88 (a)
(Gallus gallus)
Aves STK38 33 34
  • 84.73 (n)
(Anolis carolinensis)
Reptilia STK38 34
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stk38 33
  • 78.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia trc-prov 33
(Danio rerio)
Actinopterygii stk38b 34
  • 89 (a)
stk38a 34 33
  • 76.85 (n)
Dr.18403 33
fruit fly
(Drosophila melanogaster)
Insecta trc 34 33 35
  • 64.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005521 33
  • 62.8 (n)
(Caenorhabditis elegans)
Secernentea sax-1 35 34
  • 66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CBK1 36 34
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G09890 33
  • 53.15 (n)
(Glycine max)
eudicotyledons Gma.15237 33
(Oryza sativa)
Liliopsida Os.21326 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 67 (a)
Species where no ortholog for STK38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK38 Gene

Gene Tree for STK38 (if available)
Gene Tree for STK38 (if available)

Paralogs for STK38 Gene

Paralogs for STK38 Gene

genes like me logo Genes that share paralogs with STK38: view

Variants for STK38 Gene

Sequence variations from dbSNP and Humsavar for STK38 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_041196 A metastatic melanoma sample
rs1000047316 -- 36,495,032(+) CCGGG(A/G)TTTCT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000076522 -- 36,549,372(+) CTTCT(C/T)CTTCT upstream-variant-2KB
rs1000090681 -- 36,500,620(+) CTGGG(C/T)GTGGT intron-variant
rs1000122125 -- 36,541,190(+) CCACC(A/G)TGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK38 Gene

Variant ID Type Subtype PubMed ID
nsv5260 CNV deletion 18451855
nsv473402 CNV novel sequence insertion 20440878

Variation tolerance for STK38 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.20; 96.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK38 Gene

Disorders for STK38 Gene

Relevant External Links for STK38

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STK38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK38 Gene

Publications for STK38 Gene

  1. Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). (PMID: 17906693) Enomoto A … Miyagawa K (Oncogene 2008) 3 4 22 60
  2. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. (PMID: 18362890) Hirabayashi S … Hata Y (Oncogene 2008) 3 4 22 60
  3. Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. (PMID: 15197186) Bichsel SJ … Hemmings BA (The Journal of biological chemistry 2004) 3 4 22 60
  4. Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase. (PMID: 7761441) Millward T … Hemmings BA (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 60
  5. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M … van Ree JM (Biological psychiatry 2009) 3 45 60

Products for STK38 Gene

Sources for STK38 Gene