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STK38 Gene

protein-coding   GIFtS: 66
GCID: GC06M036461

Serine/Threonine Kinase 38

  Search for STK38
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Threonine Kinase 381 2     Ndr Ser/Thr Kinase-Like Protein2
Nuclear Dbf2-Related Kinase 12 3     Nuclear Dbf2-Related 12
NDR12 3     Serine Threonine Protein Kinase2
NDR1 Protein Kinase2 3     Serine/Threonine-Protein Kinase 382
EC 2.7.11.13 8     EC 2.7.118
NDR2 5     

External Ids:    HGNC: 178471   Entrez Gene: 113292   Ensembl: ENSG000001120797   OMIM: 6069645   UniProtKB: Q152083   

Export aliases for STK38 gene to outside databases

Previous GC identifers: GC06M036463 GC06M036508 GC06M036569 GC06M036180


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STK38 Gene:
STK38 (serine/threonine kinase 38) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and mitogen-activated protein kinase kinase kinase binding. An important paralog of this gene is CDC42BPG.

UniProtKB/Swiss-Prot: STK38_HUMAN, Q15208
Function: Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its
non-phosphorylated form and inhibits autophosphorylation of MAP3K2

Gene Wiki entry for STK38 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STK38 gene promoter:
         RORalpha1   Pax-3   GATA-6   AML1a   Cart-1   CUTL1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK38 promoter sequence
   Search Chromatin IP Primers for STK38

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK38


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21

STK38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK38 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M036461:  view genomic region     (about GC identifiers)

Start:
36,461,669 bp from pter      End:
36,515,247 bp from pter
Size:
53,579 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STK38_HUMAN, Q15208 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 38  
Size: 465 amino acids; 54190 Da
Cofactor: Magnesium
Subunit: Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by
MST1/STK4 (By similarity). Homodimeric S100B binds two molecules of STK38. Component of the MLL5-L complex, at
least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with MOB1 and MOB2.
Interacts with MAP3K1 and MAP3K2 (via the kinase catalytic domain). Forms a tripartite complex with MOBKL1B and
STK3/MST2
1 PDB 3D structure from and Proteopedia for STK38:
1PSB (3D)    
Secondary accessions: Q503A1

Explore the universe of human proteins at neXtProt for STK38: NX_Q15208

Explore proteomics data for STK38 at MOPED

Post-translational modifications: 

  • ISGylated (Probable)1
  • Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for STK38 (Q15208) (see all 24)
     ETVLAID  CDWWSLG  YIAETVL  KVIGRGAF 


    See STK38 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009202.1  
    ENSEMBL proteins: 
     ENSP00000229812  

    STK38 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Serine/threonine kinase 38
    Other AGC kinases
    NDR family

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry Q15208

    ProtoNet protein and cluster: Q15208

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: STK38_HUMAN, Q15208
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with STK38           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STK38_HUMAN, Q15208
    Function: Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its
    non-phosphorylated form and inhibits autophosphorylation of MAP3K2
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP
    to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by
    STK24/MST3. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that
    complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and
    MOB2/HCCA2 to the N-terminal of STK38

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA12493777
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA12493777
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI14661952
         
    Find genes that share ontologies with STK38           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for STK38:
     Decreased focal adhesion (FA)   Increased Salmonella enterica   Increased colony dispersion (i  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STK38
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    miRNA
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    miRTarBase miRNAs that target STK38:
    hsa-mir-454-3p (MIRT039243), hsa-mir-19b-3p (MIRT031271), hsa-mir-124-3p (MIRT023042), hsa-mir-16-5p (MIRT031919), hsa-let-7b-5p (MIRT052031), hsa-mir-103a-3p (MIRT027196)

    Block miRNA regulation of human, mouse, rat STK38 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK38 (see all 40):
    hsa-miR-142-5p hsa-miR-15a hsa-miR-106a hsa-miR-624* hsa-miR-218 hsa-miR-519a hsa-miR-374c hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidSTK38 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STK38

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    Addgene plasmids for STK38 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK38


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STK38_HUMAN, Q15208: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane4
    cytoskeleton2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12493777
    GO:0005737cytoplasm IDA17906693
    GO:0005886plasma membrane ----
    GO:0043231intracellular membrane-bounded organelle ----
    GO:0070688MLL5-L complex IDA--

    Find genes that share ontologies with STK38           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STK38 About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sperm Motility0.37

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STK38
        Sperm Motility



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STK38
    Interactions:

        GeneGlobe Interaction Network for STK38

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STK38 (Q152081, 2, 3 ENSP000002298124) via UniProtKB, MINT, STRING, and/or I2D (see all 151)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB1P494071, 3EBI-458376,EBI-743313 I2D: score=1 
    ARRB2P321211, 3EBI-458376,EBI-714559 I2D: score=1 
    CTDP1Q9Y5B02, 3, ENSP000002995434MINT-51651 MINT-51648 I2D: score=4 STRING: ENSP00000299543
    MTORP423452, ENSP000003545584MINT-7556061 MINT-7556024 MINT-7556076 STRING: ENSP00000354558
    MAPKAP1Q9BPZ72, ENSP000002659604MINT-7556061 MINT-7556024 MINT-7556076 STRING: ENSP00000265960
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process IDA7761441
    GO:0006468protein phosphorylation IDA12493777
    GO:0035556intracellular signal transduction IDA12493777
    GO:0043407negative regulation of MAP kinase activity IDA17906693

    Find genes that share ontologies with STK38           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STK38

    4 HMDB Compounds for STK38    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STK38 gene: 
    NM_007271.2  

    Unigene Cluster for STK38:

    Serine/threonine kinase 38
    Hs.409578  [show with all ESTs]
    Unigene Representative Sequence: BC095413
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000229812(uc003omg.3 uc003omh.3 uc003omi.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate STK38 (see all 40):
    hsa-miR-142-5p hsa-miR-15a hsa-miR-106a hsa-miR-624* hsa-miR-218 hsa-miR-519a hsa-miR-374c hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidSTK38 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat STK38

    Additional mRNA sequence: 

    AF034187.1 AF034188.1 AK095337.1 AK312559.1 BC012085.1 BC095413.1 Z35102.1 

    17 DOTS entries:

    DT.454054  DT.92058916  DT.100755193  DT.70103671  DT.100755192  DT.40231870  DT.99934755  DT.102832501 
    DT.121388045  DT.121388054  DT.92432525  DT.121388061  DT.121388062  DT.75168345  DT.95208283  DT.87002483 
    DT.99991188 

    Selected AceView cDNA sequences (see all 259):

    AI082502 BF589436 BQ441856 BQ959615 CB120471 AU121423 BU677161 BM741235 
    BM742752 BM049997 CA424896 BM743819 BQ430236 AA745766 AA617707 AA112431 
    Z38601 CD722359 BF221709 BG258009 BM783353 BC012085 AI440248 AL042016 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STK38 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d
    SP1:                    -                       -                 -                                                           -                     
    SP2:                    -                       -                 -                                                           -                     
    SP3:                                            -                 -                                                           -                     
    SP4:                                                                                                                                                
    SP5:                    -     -                 -                                                                                                   


    ECgene alternative splicing isoforms for STK38

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STK38 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTACAATTT
    STK38 Expression
    About this image


    STK38 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
    STK38 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STK38 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.409578

    UniProtKB/Swiss-Prot: STK38_HUMAN, Q15208
    Tissue specificity: Ubiquitously expressed with highest levels observed in peripheral blood leukocytes

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    QuantiFast Probe-based Assays in human, mouse, rat STK38
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK38

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STK38 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk381 , 5 serine/threonine kinase 381, 5 92.76(n)1
    98.71(a)1
      17 (15.03 cM)5
    1065041  NM_134115.21  NP_598876.11 
     289708855 
    chicken
    (Gallus gallus)
    Aves STK381 serine/threonine kinase 38 84.73(n)
    98.06(a)
      428260  XM_003642721.2  XP_003642769.2 
    lizard
    (Anolis carolinensis)
    Reptilia STK386
    serine/threonine kinase 38
    97(a)
    1 ↔ 1
    4(123458799-123479311)
    African clawed frog
    (Xenopus laevis)
    Amphibia trc-prov2 tricornered 79.22(n)    BC056129.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.184032 Danio rerio mRNA similar to serine/threonine kinase more 78.16(n)    BC044428.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta trc1 , 3 protein amino acid phosphorylation
    protein serine/threonine more3
    tricornered1
    69(a)3
    64.59(n)1
    72.58(a)1
      3 76D13
    401651  NM_001275142.11  NP_001262071.11 
    worm
    (Caenorhabditis elegans)
    Secernentea sax-13 Expression: muscle, seam cells,
    hypodermal, nerve more
    66(a)   X(3676040-3677189)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CBK1(YNL161W)4 Serine/threonine protein kinase that regulates cell more   --   14(332597-334867) 855561  NP_014238.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G098901 AT5G09890 53.15(n)
    48.29(a)
      830849  NM_001036786.1  NP_001031863.1 
    rice
    (Oryza sativa)
    Liliopsida Os.213262 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.12(n)    AK101120.1 


    ENSEMBL Gene Tree for STK38 (if available)
    TreeFam Gene Tree for STK38 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STK38 gene
    CDC42BPG2  DMPK2  LATS12  CDC42BPB2  STK38L2  MASTL2  CIT2  ROCK12  
    CDC42BPA2  LATS22  ROCK22  
    Selected SIMAP similar genes for STK38 using alignment to 1 protein entry:     STK38_HUMAN(see all similar genes):
    STK38L    CDC42BPG    ROCK1    ROCK2    CDC42BPA    CDC42BPB
    MAST1    MAST2    MAST4    DMPK    PRKAA1    RPS6KA1
    MAST3    PRKACG    PRKX    PRKY    RPS6KA5    RPS6KA6

    Find genes that share paralogs with STK38           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STK38 (see all 1203)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0411964
    A metastatic melanoma sample4--see VAR_0411962 E K mis40--------
    rs1396177591,2
    --36461238(+) AAAAGA/GTCCAC 1 -- int10--------
    rs752978671,2
    C--36461335(+) GGAAGA/CAGCAC 1 -- int13Minor allele frequency- C:0.11CSA WA EA 240
    rs1837241951,2
    C--36461363(+) GAAGTA/CTCTTC 1 -- int10--------
    rs766229441,2
    C--36461543(+) ACTCTG/TCCTCT 1 -- int10--------
    rs1887753531,2
    --36461604(+) CTTTTC/TGCTAA 1 -- int10--------
    rs1813154701,2
    --36461655(+) CACCAC/TGTATT 1 -- int10--------
    rs1161202551,2
    C,F--36461688(+) TTATTC/TAGAAG 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs1434415031,2
    --36461812(+) CATTCC/TTGCAA 1 -- ut310--------
    rs1869334131,2
    --36461825(+) CACACA/GGGAGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for STK38 (36461669 - 36515247 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STK38:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5260CNV Loss18451855
    nsv885806CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STK38
    DNA2.0 Custom Variant and Variant Library Synthesis for STK38

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606964    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for STK38:
    Diabetic retinopathy

    Find genes that share disorders with STK38           About GenesLikeMe

    Genetic Association Database (GAD): STK38
    Human Genome Epidemiology (HuGE) Navigator: STK38 (1 document)

    Export disorders for STK38 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STK38 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with STK38)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a conserved nuclear serine/threonine protein kinase. (PubMed id 7761441)1, 2, 3 Millward T.A.... Hemmings B.A. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    2. Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. (PubMed id 15197186)1, 2, 9 Bichsel S.J.... Hemmings B.A. (J. Biol. Chem. 2004)
    3. Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). (PubMed id 17906693)1, 2, 9 Enomoto A.... Miyagawa K. (Oncogene 2008)
    4. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. (PubMed id 18362890)1, 2, 9 Hirabayashi S.... Hata Y. (Oncogene 2008)
    5. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    6. Identification and Herc5-mediated ISGylation of novel target proteins. (PubMed id 16884686)1, 2 Takeuchi T.... Yokosawa H. (Biochem. Biophys. Res. Commun. 2006)
    7. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. (PubMed id 15067004)1, 2 Devroe E.... Silver P.A. (J. Biol. Chem. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase. (PubMed id 14661952)1, 2 Bhattacharya S.... Chazin W.J. (Biochemistry 2003)
    10. Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase. (PubMed id 12493777)1, 2 Tamaskovic R.... Hemmings B.A. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11329 HGNC: 17847 AceView: STK38 Ensembl:ENSG00000112079 euGenes: HUgn11329
    ECgene: STK38 H-InvDB: STK38

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STK38 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for STK38 gene:
    Search GeneIP for patents involving STK38

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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