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Aliases for STK38 Gene

Aliases for STK38 Gene

  • Serine/Threonine Kinase 38 2 3 5
  • Nuclear Dbf2-Related Kinase 1 3 4
  • NDR1 Protein Kinase 3 4
  • EC 2.7.11.1 4 61
  • NDR1 3 4
  • Serine/Threonine-Protein Kinase 38 3
  • Ndr Ser/Thr Kinase-Like Protein 3
  • EC 2.7.11 61
  • NDR 3

External Ids for STK38 Gene

Previous GeneCards Identifiers for STK38 Gene

  • GC06M036463
  • GC06M036508
  • GC06M036569
  • GC06M036461
  • GC06M036180

Summaries for STK38 Gene

Entrez Gene Summary for STK38 Gene

  • This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for STK38 Gene

STK38 (Serine/Threonine Kinase 38) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK38L.

UniProtKB/Swiss-Prot for STK38 Gene

  • Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.

Gene Wiki entry for STK38 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK38 Gene

Genomics for STK38 Gene

Regulatory Elements for STK38 Gene

Enhancers for STK38 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F036592 2.1 FANTOM5 ENCODE 20.7 -49.9 -49940 10.7 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC KCTD20 ENSG00000237719 LAP3P2 CDKN1A RAB44 CMTR1 STK38 RNU1-88P RN7SL502P TBC1D22B
GH06F036567 0.4 ENCODE 12.1 -20.3 -20310 0.4 ATF1 SAP130 CREB1 ZNF384 ZBTB33 DMAP1 KAT8 PI16 STK38 SRSF3 ETV7 RNU1-88P RAB44 KCTD20 PXT1 GC06P040045
GH06F036572 0.4 ENCODE 11.8 -25.2 -25236 1.2 CTCF ZNF362 RFX1 CEBPB ZNF384 THRB ATF2 RFX5 TEAD3 OSR2 SRSF3 STK38 KCTD20 PXT1 RAB44 GC06P040045
GH06F036477 1.2 Ensembl ENCODE 11.3 +69.3 69305 0.7 HDAC1 CBX3 ATF1 ARNT TBL1XR1 CHAMP1 GATA2 ETV6 CREM ZBTB2 KCTD20 PXT1 STK38 PI16 ETV7 LOC105375037 RAB44 PIR61796 RN7SL502P
GH06F036576 1.5 FANTOM5 Ensembl ENCODE 11.2 -31.1 -31107 4.0 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF207 SP3 SP5 STK38 RAB44 PI16 MTCH1 GC06P040045 SRSF3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around STK38 on UCSC Golden Path with GeneCards custom track

Promoters for STK38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001215480 1579 3801 HDGF ARNT MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for STK38 Gene

Chromosome:
6
Start:
36,493,889 bp from pter
End:
36,547,479 bp from pter
Size:
53,591 bases
Orientation:
Minus strand

Genomic View for STK38 Gene

Genes around STK38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK38 Gene

Proteins for STK38 Gene

  • Protein details for STK38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15208-STK38_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 38
    Protein Accession:
    Q15208
    Secondary Accessions:
    • Q503A1

    Protein attributes for STK38 Gene

    Size:
    465 amino acids
    Molecular mass:
    54190 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (By similarity). Homodimeric S100B binds two molecules of STK38. Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with MOB1 and MOB2. Interacts with MAP3K1 and MAP3K2 (via the kinase catalytic domain). Forms a tripartite complex with MOBKL1B and STK3/MST2.

    Three dimensional structures from OCA and Proteopedia for STK38 Gene

neXtProt entry for STK38 Gene

Selected DME Specific Peptides for STK38 Gene

Q15208:
  • KLSDFGLCTGLKK
  • SEKAKDLILRFC
  • RGAFGEVRLVQKKDTGH
  • CDWWSLG
  • KVIGRGAF
  • YIAETVL
  • FQNMNSKRKAETWK
  • HRDIKPDN
  • ETVLAID
  • NLYLIMEFLPGGDMMTLLMKKDTL
  • PPFCSETPQETY
  • HARKETEFLRLKRTRLGL
  • KDWVFINYTYKRFE
  • HIRERPAAI
  • SIDDTSNFD
  • YAMKILRK
  • STVGTPDYIAPE
  • KVMNWKETL
  • GTPDYIAPE
  • HIRAERDILVEAD
  • VLAIDSIHQL
  • TLENFYSNLI
  • WVVKMFYSFQDK
  • DMLEKEQV

Post-translational modifications for STK38 Gene

Other Protein References for STK38 Gene

Domains & Families for STK38 Gene

Gene Families for STK38 Gene

Suggested Antigen Peptide Sequences for STK38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15208

UniProtKB/Swiss-Prot:

STK38_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK38: view

Function for STK38 Gene

Molecular function for STK38 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38.
UniProtKB/Swiss-Prot Function:
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.

Enzyme Numbers (IUBMB) for STK38 Gene

Gene Ontology (GO) - Molecular Function for STK38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 12493777
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA 12493777
GO:0005515 protein binding IPI 9774336
GO:0005524 ATP binding IDA 12493777
genes like me logo Genes that share ontologies with STK38: view
genes like me logo Genes that share phenotypes with STK38: view

Animal Models for STK38 Gene

MGI Knock Outs for STK38:

Animal Model Products

  • Taconic Biosciences Mouse Models for STK38

miRNA for STK38 Gene

miRTarBase miRNAs that target STK38

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for STK38

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK38 Gene

Localization for STK38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK38 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK38 Gene COMPARTMENTS Subcellular localization image for STK38 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for STK38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12493777
GO:0005737 cytoplasm IEA,IDA 17906693
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0070688 MLL5-L complex IDA --
genes like me logo Genes that share ontologies with STK38: view

Pathways & Interactions for STK38 Gene

SuperPathways for STK38 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK38: view

Pathways by source for STK38 Gene

1 Qiagen pathway for STK38 Gene

SIGNOR curated interactions for STK38 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for STK38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IDA 7761441
GO:0006468 protein phosphorylation IDA 12493777
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
GO:0035556 intracellular signal transduction IDA 12493777
genes like me logo Genes that share ontologies with STK38: view

Drugs & Compounds for STK38 Gene

(3) Drugs for STK38 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
calcium Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for STK38 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK38: view

Transcripts for STK38 Gene

Unigene Clusters for STK38 Gene

Serine/threonine kinase 38:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for STK38

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK38 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: - - -
SP6: -
SP7:

Relevant External Links for STK38 Gene

GeneLoc Exon Structure for
STK38
ECgene alternative splicing isoforms for
STK38

Expression for STK38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STK38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK38 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for STK38 Gene

This gene is overexpressed in Lymph node (16.4), Peripheral blood mononuclear cells (14.0), and CD8 Tcells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STK38 Gene



Protein tissue co-expression partners for STK38 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STK38 Gene:

STK38

SOURCE GeneReport for Unigene cluster for STK38 Gene:

Hs.409578

mRNA Expression by UniProt/SwissProt for STK38 Gene:

Q15208-STK38_HUMAN
Tissue specificity: Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with STK38: view

Primer Products

Orthologs for STK38 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK38 34 35
  • 99.93 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 99 (a)
OneToMany
-- 35
  • 88 (a)
OneToMany
cow
(Bos Taurus)
Mammalia STK38 34 35
  • 96.85 (n)
dog
(Canis familiaris)
Mammalia STK38 34 35
  • 96.34 (n)
mouse
(Mus musculus)
Mammalia Stk38 34 16 35
  • 92.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STK38 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK38 34 35
  • 84.73 (n)
lizard
(Anolis carolinensis)
Reptilia STK38 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk38 34
  • 78.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia trc-prov 34
zebrafish
(Danio rerio)
Actinopterygii stk38b 35
  • 89 (a)
OneToMany
stk38a 34 35
  • 76.85 (n)
Dr.18403 34
fruit fly
(Drosophila melanogaster)
Insecta trc 36 34 35
  • 64.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005521 34
  • 62.8 (n)
worm
(Caenorhabditis elegans)
Secernentea sax-1 36 35
  • 66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CBK1 35 37
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G09890 34
  • 53.15 (n)
soybean
(Glycine max)
eudicotyledons Gma.15237 34
rice
(Oryza sativa)
Liliopsida Os.21326 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 67 (a)
OneToMany
Species where no ortholog for STK38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK38 Gene

ENSEMBL:
Gene Tree for STK38 (if available)
TreeFam:
Gene Tree for STK38 (if available)

Paralogs for STK38 Gene

genes like me logo Genes that share paralogs with STK38: view

Variants for STK38 Gene

Sequence variations from dbSNP and Humsavar for STK38 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_041196 A metastatic melanoma sample
rs10541409 -- 36,532,308(+) TCTGC(-/AT)AAAAA intron-variant
rs10566463 -- 36,516,990(+) AACTG(-/TTTA)TTTTT intron-variant
rs10588696 -- 36,549,126(+) GGGGG(A/G)GGGGG upstream-variant-2KB
rs10681953 -- 36,522,890(+) AAGAA(-/GAA)AATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK38 Gene

Variant ID Type Subtype PubMed ID
nsv473402 CNV novel sequence insertion 20440878
nsv5260 CNV deletion 18451855

Variation tolerance for STK38 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.20; 96.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK38 Gene

Disorders for STK38 Gene

Relevant External Links for STK38

Genetic Association Database (GAD)
STK38
Human Genome Epidemiology (HuGE) Navigator
STK38
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK38

No disorders were found for STK38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK38 Gene

Publications for STK38 Gene

  1. Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). (PMID: 17906693) Enomoto A. … Miyagawa K. (Oncogene 2008) 3 4 22 64
  2. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. (PMID: 18362890) Hirabayashi S. … Hata Y. (Oncogene 2008) 3 4 22 64
  3. Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. (PMID: 15197186) Bichsel S.J. … Hemmings B.A. (J. Biol. Chem. 2004) 3 4 22 64
  4. Molecular cloning and characterization of a conserved nuclear serine/threonine protein kinase. (PMID: 7761441) Millward T.A. … Hemmings B.A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 64
  5. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M. … van Ree J.M. (Biol. Psychiatry 2009) 3 46 64

Products for STK38 Gene

Sources for STK38 Gene

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