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Aliases for STK38 Gene

Aliases for STK38 Gene

  • Serine/Threonine Kinase 38 2 3
  • Nuclear Dbf2-Related Kinase 1 3 4
  • NDR1 Protein Kinase 3 4
  • EC 2.7.11.1 4 64
  • NDR1 3 4
  • NDR 3 6
  • Serine/Threonine-Protein Kinase 38 3
  • Ndr Ser/Thr Kinase-Like Protein 3
  • EC 2.7.11 64

External Ids for STK38 Gene

Summaries for STK38 Gene

Entrez Gene Summary for STK38 Gene

  • This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for STK38 Gene

STK38 (Serine/Threonine Kinase 38) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include protein serine/threonine kinase activity and mitogen-activated protein kinase kinase kinase binding. An important paralog of this gene is STK38L.

UniProtKB/Swiss-Prot for STK38 Gene

  • Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.

Gene Wiki entry for STK38 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK38 Gene

Genomics for STK38 Gene

Genomic Location for STK38 Gene

Start:
36,493,889 bp from pter
End:
36,547,479 bp from pter
Size:
53,591 bases
Orientation:
Minus strand

Genomic View for STK38 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STK38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK38 Gene

Regulatory Elements for STK38 Gene

Proteins for STK38 Gene

  • Protein details for STK38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15208-STK38_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 38
    Protein Accession:
    Q15208
    Secondary Accessions:
    • Q503A1

    Protein attributes for STK38 Gene

    Size:
    465 amino acids
    Molecular mass:
    54190 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (By similarity). Homodimeric S100B binds two molecules of STK38. Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with MOB1 and MOB2. Interacts with MAP3K1 and MAP3K2 (via the kinase catalytic domain). Forms a tripartite complex with MOBKL1B and STK3/MST2.

    Three dimensional structures from OCA and Proteopedia for STK38 Gene

neXtProt entry for STK38 Gene

Proteomics data for STK38 Gene at MOPED

Post-translational modifications for STK38 Gene

Other Protein References for STK38 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for STK38 Gene

UniProtKB/Swiss-Prot:

STK38_HUMAN
Domain:
  • Contains 1 AGC-kinase C-terminal domain.:
    • Q15208
  • Contains 1 protein kinase domain.:
    • Q15208
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.:
    • Q15208
genes like me logo Genes that share domains with STK38: view

Function for STK38 Gene

Molecular function for STK38 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38.
UniProtKB/Swiss-Prot Function: Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.

Enzyme Numbers (IUBMB) for STK38 Gene

Gene Ontology (GO) - Molecular Function for STK38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 12493777
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 12493777
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 14661952
genes like me logo Genes that share ontologies with STK38: view
genes like me logo Genes that share phenotypes with STK38: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for STK38 Gene

Localization for STK38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK38 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK38 Gene COMPARTMENTS Subcellular localization image for STK38 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for STK38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12493777
GO:0005737 cytoplasm IDA 17906693
GO:0070688 MLL5-L complex IDA --
genes like me logo Genes that share ontologies with STK38: view

Pathways for STK38 Gene

SuperPathways for STK38 Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK38: view

Pathways by source for STK38 Gene

1 Qiagen pathway for STK38 Gene

Gene Ontology (GO) - Biological Process for STK38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IDA 7761441
GO:0006468 protein phosphorylation IDA 12493777
GO:0035556 intracellular signal transduction IDA 12493777
GO:0043407 negative regulation of MAP kinase activity IDA 17906693
genes like me logo Genes that share ontologies with STK38: view

Compounds for STK38 Gene

(4) HMDB Compounds for STK38 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with STK38: view

Transcripts for STK38 Gene

Unigene Clusters for STK38 Gene

Serine/threonine kinase 38:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK38 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: - - -
SP6: -
SP7:

Relevant External Links for STK38 Gene

GeneLoc Exon Structure for
STK38
ECgene alternative splicing isoforms for
STK38

Expression for STK38 Gene

mRNA expression in normal human tissues for STK38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK38 Gene

This gene is overexpressed in Whole Blood (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STK38 Gene

SOURCE GeneReport for Unigene cluster for STK38 Gene Hs.409578

mRNA Expression by UniProt/SwissProt for STK38 Gene

Q15208-STK38_HUMAN
Tissue specificity: Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.
genes like me logo Genes that share expressions with STK38: view

Orthologs for STK38 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK38 36
  • 99.93 (n)
  • 99.78 (a)
STK38 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STK38 36
  • 96.85 (n)
  • 99.35 (a)
STK38 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK38 36
  • 96.34 (n)
  • 99.78 (a)
STK38 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk38 36
  • 92.76 (n)
  • 98.71 (a)
Stk38 16
Stk38 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 99 (a)
OneToMany
-- 37
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia STK38 37
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK38 36
  • 84.73 (n)
  • 98.06 (a)
STK38 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK38 37
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia trc-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia stk38 36
  • 78.92 (n)
  • 92.9 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18403 36
stk38a 36
  • 76.85 (n)
  • 92.26 (a)
stk38a 37
  • 92 (a)
OneToMany
stk38b 37
  • 89 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005521 36
  • 62.8 (n)
  • 72.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta trc 36
  • 64.59 (n)
  • 72.58 (a)
trc 37
  • 68 (a)
OneToMany
trc 38
  • 69 (a)
worm
(Caenorhabditis elegans)
Secernentea sax-1 37
  • 62 (a)
OneToMany
sax-1 38
  • 66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CBK1 37
  • 30 (a)
OneToMany
CBK1 39
soybean
(Glycine max)
eudicotyledons Gma.15237 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G09890 36
  • 53.15 (n)
  • 48.29 (a)
rice
(Oryza sativa)
Liliopsida Os.21326 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 67 (a)
OneToMany
Species with no ortholog for STK38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK38 Gene

ENSEMBL:
Gene Tree for STK38 (if available)
TreeFam:
Gene Tree for STK38 (if available)

Paralogs for STK38 Gene

genes like me logo Genes that share paralogs with STK38: view

Variants for STK38 Gene

Sequence variations from dbSNP and Humsavar for STK38 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs4598 -- 36,494,230(+) CCAAA(A/G)TAGTT utr-variant-3-prime
rs586036 -- 36,546,394(-) TAAAA(A/C)AACCA intron-variant
rs588496 -- 36,508,270(-) GTAAA(C/T)TGAAT intron-variant
rs588566 -- 36,508,311(-) CCAGT(A/G)TTAGG intron-variant
rs595954 -- 36,497,057(-) CTTCA(C/G/T)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK38 Gene

Variant ID Type Subtype PubMed ID
nsv885806 CNV Gain 21882294
nsv5260 CNV Loss 18451855

Relevant External Links for STK38 Gene

HapMap Linkage Disequilibrium report
STK38

Disorders for STK38 Gene

(1) University of Copenhagen DISEASES for STK38 Gene

Relevant External Links for STK38

Genetic Association Database (GAD)
STK38
Human Genome Epidemiology (HuGE) Navigator
STK38
genes like me logo Genes that share disorders with STK38: view

No data available for UniProtKB/Swiss-Prot for STK38 Gene

Publications for STK38 Gene

  1. Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. (PMID: 15197186) Bichsel S.J. … Hemmings B.A. (J. Biol. Chem. 2004) 3 4 23
  2. Molecular cloning and characterization of a conserved nuclear serine/threonine protein kinase. (PMID: 7761441) Millward T.A. … Hemmings B.A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4
  3. Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). (PMID: 17906693) Enomoto A. … Miyagawa K. (Oncogene 2008) 3 4 23
  4. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. (PMID: 18362890) Hirabayashi S. … Hata Y. (Oncogene 2008) 3 4 23
  5. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. (PMID: 15067004) Devroe E. … Silver P.A. (J. Biol. Chem. 2004) 3 4

Products for STK38 Gene

  • Addgene plasmids for STK38

Sources for STK38 Gene

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