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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STK38 Gene

protein-coding   GIFtS: 66
GCID: GC06M036461

Serine/Threonine Kinase 38

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine/Threonine Kinase 381 2     Ndr Ser/Thr Kinase-Like Protein2
Nuclear Dbf2-Related Kinase 12 3     Nuclear Dbf2-Related 12
NDR12 3     Serine Threonine Protein Kinase2
NDR1 Protein Kinase2 3     Serine/Threonine-Protein Kinase 382
EC 2.7.11.13 8     EC 2.7.118
NDR2 5     

External Ids:    HGNC: 178471   Entrez Gene: 113292   Ensembl: ENSG000001120797   OMIM: 6069645   UniProtKB: Q152083   

Export aliases for STK38 gene to outside databases

Previous GC identifers: GC06M036463 GC06M036508 GC06M036569 GC06M036180


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for STK38 Gene: 
STK38 (serine/threonine kinase 38) is a protein-coding gene. Diseases associated with STK38 include autism spectrum disorder, and diabetic retinopathy, and among its related super-pathways are Cellular Effects of Sildenafil. GO annotations related to this gene include protein serine/threonine kinase activity and mitogen-activated protein kinase kinase kinase binding. An important paralog of this gene is CDC42BPG.

UniProtKB/Swiss-Prot: STK38_HUMAN, Q15208
Function: Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its
non-phosphorylated form and inhibits autophosphorylation of MAP3K2

Gene Wiki entry for STK38 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STK38 gene promoter:
         RORalpha1   Pax-3   GATA-6   AML1a   Cart-1   CUTL1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK38 promoter sequence
   Search SABiosciences Chromatin IP Primers for STK38

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK38


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21

STK38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK38 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M036461:  view genomic region     (about GC identifiers)

Start:
36,461,669 bp from pter      End:
36,515,247 bp from pter
Size:
53,579 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STK38_HUMAN, Q15208 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 38  
Size: 465 amino acids; 54190 Da
Cofactor: Magnesium
Subunit: Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by
MST1/STK4 (By similarity). Homodimeric S100B binds two molecules of STK38. Component of the MLL5-L complex, at
least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with MOB1 and MOB2.
Interacts with MAP3K1 and MAP3K2 (via the kinase catalytic domain). Forms a tripartite complex with MOBKL1B and
STK3/MST2
Subcellular location: Nucleus. Cytoplasm
1 PDB 3D structure from and Proteopedia for STK38:
1PSB (3D)    
Secondary accessions: Q503A1

Explore the universe of human proteins at neXtProt for STK38: NX_Q15208

Explore proteomics data for STK38 at MOPED 

Post-translational modifications:

  • UniProtKB: ISGylated (Probable)
  • UniProtKB: Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15208

  • 4/24 DME Specific Peptides for STK38 (Q15208) (see all 24)
     ETVLAID  CDWWSLG  YIAETVL  KVIGRGAF 

    STK38 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STK38 Protein Expression
    REFSEQ proteins: NP_009202.1  
    ENSEMBL proteins: 
     ENSP00000229812  

    Human Recombinant Protein Products for STK38: 
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    Cloud-Clone Corp. Proteins for STK38 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    STK38 for ontologies           About GeneDecksing



    STK38 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Serine/threonine kinase 38 
    Other AGC kinases
    NDR family

    5/7 InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry Q15208

    ProtoNet protein and cluster: Q15208

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: STK38_HUMAN, Q15208
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    STK38 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STK38_HUMAN, Q15208
    Function: Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its
    non-phosphorylated form and inhibits autophosphorylation of MAP3K2
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP
    to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by
    STK24/MST3. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that
    complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and
    MOB2/HCCA2 to the N-terminal of STK38

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA12493777
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA12493777
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI14661952
         
    STK38 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for STK38:
     Decreased focal adhesion (FA)   Increased Salmonella enterica   Increased colony dispersion (i  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for STK38 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STK38

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STK38 
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    SwitchGear 3'UTR luciferase reporter plasmidSTK38 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK38


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STK38 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sperm Motility0.37

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for STK38
        Sperm Motility



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STK38

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for STK38 (Q152081, 2, 3 ENSP000002298124) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTDP1Q9Y5B02, 3, ENSP000002995434MINT-51651 MINT-51648 I2D: score=4 STRING: ENSP00000299543
    MOB1AQ9H8S91, 3, ENSP000003793644EBI-458376,EBI-748229 I2D: score=2 STRING: ENSP00000379364
    ARRB1P494071, 3EBI-458376,EBI-743313 I2D: score=1 
    ARRB2P321211, 3EBI-458376,EBI-714559 I2D: score=1 
    MTORP423452, ENSP000003545584MINT-7556061 MINT-7556024 MINT-7556076 STRING: ENSP00000354558
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process IDA7761441
    GO:0006468protein phosphorylation IDA12493777
    GO:0007243intracellular protein kinase cascade IDA12493777
    GO:0043407negative regulation of MAP kinase activity IDA17906693

    STK38 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STK38

    4 HMDB Compounds for STK38    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about STK38

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STK38 gene: 
    NM_007271.2  

    Unigene Cluster for STK38:

    Serine/threonine kinase 38
    Hs.409578  [show with all ESTs]
    Unigene Representative Sequence: BC095413
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000229812(uc003omg.3 uc003omh.3 uc003omi.3)
    miRNA
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    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate STK38 (see all 40):
    hsa-miR-142-5p hsa-miR-15a hsa-miR-106a hsa-miR-624* hsa-miR-218 hsa-miR-519a hsa-miR-374c hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidSTK38 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF034187.1 AF034188.1 AK095337.1 AK312559.1 BC012085.1 BC095413.1 Z35102.1 

    17 DOTS entries:

    DT.454054  DT.92058916  DT.100755193  DT.70103671  DT.100755192  DT.40231870  DT.99934755  DT.102832501 
    DT.121388045  DT.121388054  DT.92432525  DT.121388061  DT.121388062  DT.75168345  DT.95208283  DT.87002483 
    DT.99991188 

    24/259 AceView cDNA sequences (see all 259):

    BM543341 BM783353 T39655 BP356988 AA112431 CD722359 AA745766 BM741235 
    BU677161 BF221709 T34839 CB852919 BI260781 BM742752 AI066719 NM_007271 
    AA085438 AA617707 BP368363 AU121423 AA705778 AA808647 AL042016 BP873110 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for STK38 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d
    SP1:                    -                       -                 -                                                           -                     
    SP2:                    -                       -                 -                                                           -                     
    SP3:                                            -                 -                                                           -                     
    SP4:                                                                                                                                                
    SP5:                    -     -                 -                                                                                                   


    ECgene alternative splicing isoforms for STK38

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STK38 expression in normal human tissues (normalized intensities)      STK38 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTACAATTT
    STK38 Expression
    About this image


    STK38 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Rhombencephalon
     
     Oral Cavity (Gastrointestinal Tract)
             mouth   
     
     Blood (Hematopoietic System)

    See STK38 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STK38

    SOURCE GeneReport for Unigene cluster: Hs.409578

    UniProtKB/Swiss-Prot: STK38_HUMAN, Q15208
    Tissue specificity: Ubiquitously expressed with highest levels observed in peripheral blood leukocytes

        SABiosciences Custom PCR Arrays for STK38
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK38

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STK38 gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk381 , 5 serine/threonine kinase 381, 5 92.76(n)1
    98.71(a)1
      17 (15.03 cM)5
    1065041  NM_134115.21  NP_598876.11 
     289708855 
    chicken
    (Gallus gallus)
    Aves STK381 serine/threonine kinase 38 84.93(n)
    98.03(a)
      428260  XM_425819.3  XP_425819.3 
    lizard
    (Anolis carolinensis)
    Reptilia STK386
    Uncharacterized protein
    97(a)
    1 ↔ 1
    4(123458799-123479311)
    African clawed frog
    (Xenopus laevis)
    Amphibia trc-prov2 tricornered 79.22(n)    BC056129.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.184032 Danio rerio mRNA similar to serine/threonine kinase more 78.16(n)    BC044428.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta trc3 protein amino acid phosphorylation
    protein serine/threonine more
    69(a)   3 76D1   --
    worm
    (Caenorhabditis elegans)
    Secernentea sax-13 Expression: muscle, seam cells,
    hypodermal, nerve more
    66(a)   X(3676040-3677189)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G204701 putative serine/threonine-protein kinase 54.82(n)
    50.34(a)
      816567  NM_127606.2  NP_179637.2 
    rice
    (Oryza sativa)
    Liliopsida Os.213262 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.12(n)    AK101120.1 


    ENSEMBL Gene Tree for STK38 (if available)
    TreeFam Gene Tree for STK38 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STK38 gene
    CDC42BPG2  DMPK2  LATS12  CDC42BPB2  STK38L2  MASTL2  CIT2  ROCK12  
    CDC42BPA2  LATS22  ROCK22  
    18/31 SIMAP similar genes for STK38 using alignment to 1 protein entry:     STK38_HUMAN(see all similar genes):
    STK38L    CDC42BPG    ROCK1    ROCK2    CDC42BPA    CDC42BPB
    MAST1    MAST2    MAST4    DMPK    PRKAA1    RPS6KA1
    MAST3    PRKACG    PRKX    PRKY    RPS6KA5    RPS6KA6

    STK38 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1203 SNPs in STK38 are shown (see all 1203)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0411964
    A metastatic melanoma sample4--see VAR_0411962 E K mis40--------
    rs1396177591,2
    --36461238(+) AAAAGA/GTCCAC 1 -- int10--------
    rs752978671,2
    C--36461335(+) GGAAGA/CAGCAC 1 -- int13Minor allele frequency- C:0.11CSA WA EA 240
    rs1837241951,2
    C--36461363(+) GAAGTA/CTCTTC 1 -- int10--------
    rs766229441,2
    C--36461543(+) ACTCTG/TCCTCT 1 -- int10--------
    rs1887753531,2
    --36461604(+) CTTTTC/TGCTAA 1 -- int10--------
    rs1813154701,2
    --36461655(+) CACCAC/TGTATT 1 -- int10--------
    rs1161202551,2
    C,F--36461688(+) TTATTC/TAGAAG 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs1434415031,2
    --36461812(+) CATTCC/TTGCAA 1 -- ut310--------
    rs1869334131,2
    --36461825(+) CACACA/GGGAGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for STK38 (36461669 - 36515247 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STK38:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5260CNV Loss18451855
    nsv885806CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606964    OMIM disorders: --

    3 diseases for STK38:    About MalaCards
    autism spectrum disorder    diabetic retinopathy    neuronitis

    1 disease from the University of Copenhagen DISEASES database for STK38:
    Diabetic retinopathy

    STK38 for disorders           About GeneDecksing

    Genetic Association Database (GAD): STK38
    Human Genome Epidemiology (HuGE) Navigator: STK38 (1 document)

    Export disorders for STK38 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STK38 gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with STK38)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a conserved nuclear serine/threonine protein kinase. (PubMed id 7761441)1, 2, 3 Millward T.A.... Hemmings B.A. (1995)
    2. Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. (PubMed id 15197186)1, 2, 9 Bichsel S.J.... Hemmings B.A. (2004)
    3. Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). (PubMed id 17906693)1, 2, 9 Enomoto A....Miyagawa K. (2008)
    4. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. (PubMed id 18362890)1, 2, 9 Hirabayashi S....Hata Y. (2008)
    5. GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. (PubMed id 19377461)1, 2 Fujiki R.... Kato S. (2009)
    6. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    7. Identification and Herc5-mediated ISGylation of novel target proteins. (PubMed id 16884686)1, 2 Takeuchi T....Yokosawa H. (2006)
    8. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. (PubMed id 15067004)1, 2 Devroe E.... Silver P.A. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase. (PubMed id 14661952)1, 2 Bhattacharya S.... Chazin W.J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11329 HGNC: 17847 AceView: STK38 Ensembl:ENSG00000112079 euGenes: HUgn11329
    ECgene: STK38 H-InvDB: STK38

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STK38 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STK38 gene:
    Search GeneIP for patents involving STK38

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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