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Aliases for STK36 Gene

Aliases for STK36 Gene

  • Serine/Threonine Kinase 36 2 3 5
  • Fused Homolog 3 4
  • EC 2.7.11.1 4 61
  • Serine/Threonine Kinase 36 (Fused Homolog, Drosophila) 2
  • Serine/Threonine-Protein Kinase 36 3
  • Testicular Tissue Protein Li 188 3
  • Fused Homolog (Drosophila) 2
  • EC 2.7.11 61
  • KIAA1278 4
  • FU 3

External Ids for STK36 Gene

Previous GeneCards Identifiers for STK36 Gene

  • GC02P217552
  • GC02P218258
  • GC02P219500
  • GC02P219739
  • GC02P219362
  • GC02P219245
  • GC02P219536
  • GC02P211390

Summaries for STK36 Gene

Entrez Gene Summary for STK36 Gene

  • This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for STK36 Gene

STK36 (Serine/Threonine Kinase 36) is a Protein Coding gene. Diseases associated with STK36 include Congenital Hydrocephalus and Papillary Serous Adenocarcinoma. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways and Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKC.

UniProtKB/Swiss-Prot for STK36 Gene

  • Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia.

Gene Wiki entry for STK36 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK36 Gene

Genomics for STK36 Gene

Regulatory Elements for STK36 Gene

Enhancers for STK36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G219415 1.3 Ensembl ENCODE dbSUPER 19.6 +746.5 746508 6.3 RING1 PKNOX1 KLF1 SUZ12 NFIB TAL1 ZMYM3 MAX ZNF664 TCF12 STK36 RNF25 CNOT9 ENSG00000227432 ASIC4 DNPEP GLB1L DES ENSG00000234638
GH02G219368 1.2 Ensembl ENCODE 19 +697.3 697280 2.4 FOXA2 FEZF1 ZNF2 GATA2 ZNF416 KLF7 YY2 REST TSHZ1 ZNF488 RNF25 CNOT9 STK36 ANKZF1 ENSG00000269068 RESP18 ASIC4 TMEM198 PTPRN SPEG
GH02G218393 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -271.0 -271020 14.4 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 USP37 TMBIM1 AAMP PNKD CYP27A1 CDK5R2 CNOT9 STK36 PTPRN CATIP-AS1
GH02G217845 2 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -819.3 -819264 15.3 HDGF PKNOX1 CREB3L1 MLX ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 TNS1 LOC105373878 STK36 AAMP PLCD4 PNKD ARPC2 GC02P217871 GC02P217829
GH02G217987 1.5 Ensembl ENCODE dbSUPER 11.9 -683.0 -683031 2.8 FOXA2 SIN3A ARID4B YBX1 ZNF2 ZNF48 ZBTB7B SLC30A9 ZNF207 ZNF143 RNF25 RUFY4 STK36 CNOT9 AAMP LOC105373878 TNS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STK36 on UCSC Golden Path with GeneCards custom track

Promoters for STK36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000130437 -126 1401 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF143 KLF13 ZNF263 MXD4 REST

Genomic Location for STK36 Gene

Chromosome:
2
Start:
218,672,026 bp from pter
End:
218,702,717 bp from pter
Size:
30,692 bases
Orientation:
Plus strand

Genomic View for STK36 Gene

Genes around STK36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK36 Gene

Proteins for STK36 Gene

  • Protein details for STK36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRP7-STK36_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 36
    Protein Accession:
    Q9NRP7
    Secondary Accessions:
    • B7WPM3
    • Q8TC32
    • Q9H9N9
    • Q9UF35
    • Q9ULE2

    Protein attributes for STK36 Gene

    Size:
    1315 amino acids
    Molecular mass:
    143995 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with GLI1, GLI2 and GLI3 (PubMed:10806483). Interacts with SPAG16 and KIF27.
    SequenceCaution:
    • Sequence=BAA86592.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14184.1; Type=Frameshift; Positions=987; Evidence={ECO:0000305};

    Alternative splice isoforms for STK36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK36 Gene

Selected DME Specific Peptides for STK36 Gene

Q9NRP7:
  • MIGEGSFGR
  • VLTSIKGTPLYM
  • LVSALYYLHS
  • WSVGCIL

Post-translational modifications for STK36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for STK36 Gene

Gene Families for STK36 Gene

Suggested Antigen Peptide Sequences for STK36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRP7

UniProtKB/Swiss-Prot:

STK36_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK36: view

Function for STK36 Gene

Molecular function for STK36 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia.

Enzyme Numbers (IUBMB) for STK36 Gene

Gene Ontology (GO) - Molecular Function for STK36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IC 10806483
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,TAS 10806483
GO:0005515 protein binding IPI 10806483
GO:0005524 ATP binding IEA,TAS 10806483
genes like me logo Genes that share ontologies with STK36: view
genes like me logo Genes that share phenotypes with STK36: view

Animal Models for STK36 Gene

MGI Knock Outs for STK36:

Animal Model Products

  • Taconic Biosciences Mouse Models for STK36

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK36 Gene

Localization for STK36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK36 Gene

Cytoplasm. Nucleus. Note=Low levels also present in the nucleus. {ECO:0000269 PubMed:10806483}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK36 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for STK36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 10806483
GO:0005737 cytoplasm IEA,IDA 10806483
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with STK36: view

Pathways & Interactions for STK36 Gene

genes like me logo Genes that share pathways with STK36: view

SIGNOR curated interactions for STK36 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for STK36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement IEA --
GO:0006468 protein phosphorylation IEA,TAS 10806483
GO:0007228 positive regulation of hh target transcription factor activity ISS --
GO:0007275 multicellular organism development IEA --
GO:0007420 brain development IEA --
genes like me logo Genes that share ontologies with STK36: view

Drugs & Compounds for STK36 Gene

(2) Drugs for STK36 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for STK36 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK36: view

Transcripts for STK36 Gene

Unigene Clusters for STK36 Gene

Serine/threonine kinase 36:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK36 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^
SP1: - - - - - -
SP2: - - - - - -
SP3:
SP4: -
SP5: -
SP6: - - - - -
SP7: - -
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13:

ExUns: 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for STK36 Gene

GeneLoc Exon Structure for
STK36
ECgene alternative splicing isoforms for
STK36

Expression for STK36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STK36 Gene

Protein differential expression in normal tissues from HIPED for STK36 Gene

This gene is overexpressed in Bone (62.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STK36 Gene



Protein tissue co-expression partners for STK36 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STK36 Gene:

STK36

SOURCE GeneReport for Unigene cluster for STK36 Gene:

Hs.471404

mRNA Expression by UniProt/SwissProt for STK36 Gene:

Q9NRP7-STK36_HUMAN
Tissue specificity: Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells.

Evidence on tissue expression from TISSUES for STK36 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with STK36: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK36 Gene

Orthologs for STK36 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK36 34 35
  • 99.52 (n)
cow
(Bos Taurus)
Mammalia STK36 34 35
  • 88.43 (n)
dog
(Canis familiaris)
Mammalia STK36 34 35
  • 88.25 (n)
mouse
(Mus musculus)
Mammalia Stk36 34 16 35
  • 85.77 (n)
rat
(Rattus norvegicus)
Mammalia Stk36 34
  • 85.68 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STK36 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK36 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK36 34 35
  • 61.05 (n)
lizard
(Anolis carolinensis)
Reptilia STK36 35
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii stk36 35
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fu 36 35
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea air-1 35
  • 28 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IPL1 35
  • 23 (a)
OneToMany
FMP48 37
rice
(Oryza sativa)
Liliopsida Os.24564 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToOne
Species where no ortholog for STK36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for STK36 Gene

ENSEMBL:
Gene Tree for STK36 (if available)
TreeFam:
Gene Tree for STK36 (if available)

Paralogs for STK36 Gene

Paralogs for STK36 Gene

genes like me logo Genes that share paralogs with STK36: view

Variants for STK36 Gene

Sequence variations from dbSNP and Humsavar for STK36 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_041185 A breast pleomorphic lobular carcinoma sample
VAR_041187 An ovarian papillary serous adenocarcinoma sample
VAR_041193 An ovarian serous carcinoma sample
rs1000101842 -- 218,685,495(+) CAGGC(A/C)AAAAT intron-variant
rs1000314415 -- 218,693,286(+) CCAGC(A/T)CAGGC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for STK36 Gene

Variant ID Type Subtype PubMed ID
esv33891 CNV loss 17666407

Variation tolerance for STK36 Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.64; 97.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK36 Gene

Human Gene Mutation Database (HGMD)
STK36
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK36 Gene

Disorders for STK36 Gene

MalaCards: The human disease database

(3) MalaCards diseases for STK36 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
congenital hydrocephalus
papillary serous adenocarcinoma
  • micropapillary serous carcinoma
hydrocephalus
  • hydrocephalus, nonsyndromic, autosomal recessive
- elite association - COSMIC cancer census association via MalaCards
Search STK36 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STK36

Genetic Association Database (GAD)
STK36
Human Genome Epidemiology (HuGE) Navigator
STK36
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK36
genes like me logo Genes that share disorders with STK36: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK36 Gene

Publications for STK36 Gene

  1. Gli regulation by the opposing activities of fused and suppressor of fused. (PMID: 10806483) Murone M. … de Sauvage F.J. (Nat. Cell Biol. 2000) 2 3 4 64
  2. A possible role of mouse Fused (STK36) in Hedgehog signaling and Gli transcription factor regulation. (PMID: 18600476) Maloveryan A. … Kogerman P. (J Cell Commun Signal 2007) 3 22 64
  3. Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels. (PMID: 17054904) Kise Y. … Miki H. (Biochem. Biophys. Res. Commun. 2006) 3 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for STK36 Gene

Sources for STK36 Gene

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