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STK36 Gene

protein-coding   GIFtS: 65
GCID: GC02P219536

Serine/Threonine Kinase 36

(Previous names: serine/threonine kinase 36 (fused homolog, Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Threonine Kinase 361 2     Fused Homolog (Drosophila)1
Fused Homolog2 3     Serine/Threonine Kinase 36 (Fused Homolog, Drosophila)1
EC 2.7.11.13 8     Serine/Threonine-Protein Kinase 362
FU2 5     EC 2.7.118
KIAA12783 5     

External Ids:    HGNC: 172091   Entrez Gene: 271482   Ensembl: ENSG000001634827   OMIM: 6076525   UniProtKB: Q9NRP73   

Export aliases for STK36 gene to outside databases

Previous GC identifers: GC02P217552 GC02P218258 GC02P219500 GC02P219739 GC02P219362 GC02P219245 GC02P211390


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STK36 Gene:
This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a
Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive
regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest
that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in
motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it
has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this
gene results in multiple transcript variants. (provided by RefSeq, Aug 2011)

GeneCards Summary for STK36 Gene:
STK36 (serine/threonine kinase 36) is a protein-coding gene. Diseases associated with STK36 include hydrocephalus, and primary ciliary dyskinesia. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is AURKA.

UniProtKB/Swiss-Prot: STK36_HUMAN, Q9NRP7
Function: Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by
regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators
GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an
additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an
active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the
homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair
apparatus of motile cilia

Gene Wiki entry for STK36 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STK36 gene promoter:
         E2F-3a   E2F-4   GR   AP-1   p53   GR-beta   ATF-2   CREB   deltaCREB   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK36 promoter sequence
   Search Chromatin IP Primers for STK36

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

STK36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK36 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219536:  view genomic region     (about GC identifiers)

Start:
219,536,749 bp from pter      End:
219,567,440 bp from pter
Size:
30,692 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STK36_HUMAN, Q9NRP7 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 36  
Size: 1315 amino acids; 143995 Da
Cofactor: Magnesium
Subunit: Interacts with SPAG16 and KIF27 (By similarity)
Sequence caution: Sequence=BAA86592.1; Type=Erroneous initiation; Sequence=BAB14184.1; Type=Frameshift;
Positions=987;
Secondary accessions: B7WPM3 Q8TC32 Q9H9N9 Q9UF35 Q9ULE2
Alternative splicing: 2 isoforms:  Q9NRP7-1   Q9NRP7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STK36: NX_Q9NRP7

Explore proteomics data for STK36 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for STK36 (Q9NRP7)
     WSVGCIL  MIGEGSFGR  LVSALYYLHS  VLTSIKGTPLYM 


    See STK36 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230242.1  NP_056505.2  

    ENSEMBL proteins: 
     ENSP00000295709   ENSP00000375954   ENSP00000400055   ENSP00000394095   ENSP00000403527  
     ENSP00000406184   ENSP00000409688   ENSP00000404719   ENSP00000375955  

    STK36 Human Recombinant Protein Products:

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    Novus Biologicals STK36 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STK36

    STK36 Antibody Products:

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    Cloud-Clone Corp. CLIAs for STK36


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine kinase 36
    Unc-51-like kinase (ULK) family

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR011989 ARM-like
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q9NRP7

    ProtoNet protein and cluster: Q9NRP7

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: STK36_HUMAN, Q9NRP7
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    STK36 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STK36_HUMAN, Q9NRP7
    Function: Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by
    regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators
    GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an
    additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an
    active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the
    homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair
    apparatus of motile cilia
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IC10806483
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS10806483
    GO:0004713protein tyrosine kinase activity ----
    GO:0005488binding ----
         
    STK36 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for STK36:
     Decreased substrate adherent c  PARP inhibitor sensitization 

         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Stk36):
     behavior/neurological  craniofacial  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     immune system  mortality/aging  nervous system  no phenotypic analysis  renal/urinary system 
     reproductive system  respiratory system  skeleton 

    STK36 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for STK36: Stk36tm1Lex Stk36tm1.1Ptch Stk36tm1Fjs

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STK36
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STK36
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STK36

    miRNA
    Products:
        
    miRTarBase miRNAs that target STK36:
    hsa-mir-124-3p (MIRT022162)

    Block miRNA regulation of human, mouse, rat STK36 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK36 (see all 11):
    hsa-miR-4300 hsa-miR-520d-5p hsa-miR-571 hsa-miR-1236 hsa-miR-216b hsa-miR-920 hsa-miR-942 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidSTK36 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STK36
    Predesigned siRNA for gene silencing in human, mouse, rat STK36

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: STK36 (NM_015690)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STK36
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK36

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    Browse ESI BIO Cell Lines and PureStem Progenitors for STK36 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK36


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STK36_HUMAN, Q9NRP7: Cytoplasm. Nucleus. Note=Low levels also present in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    plasma membrane3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10806483
    GO:0005737cytoplasm IDA--

    STK36 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STK36 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Basal cell carcinoma
    Basal cell carcinoma0.43
    Hedgehog signaling pathway0.43
    2Activation of cAMP-Dependent PKA
    Activation of PKA through GPCR0.71
    3ERK Signaling
    Molecular Mechanisms of Cancer0.51
    4Sweet Taste Signaling
    Sperm Motility0.37
    5Hedgehog Signaling Pathway
    Hedgehog Signaling Pathway0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for STK36
        Activation of PKA through GPCR
    Molecular Mechanisms of Cancer
    Sperm Motility
    Hedgehog Signaling in Mammals

    2 BioSystems Pathways for STK36
        Hedgehog Signaling Pathway
    Hedgehog signaling events mediated by Gli proteins


    3 Kegg Pathways  (Kegg details for STK36):
        Hedgehog signaling pathway
    Pathways in cancer
    Basal cell carcinoma


    STK36 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including STK36: 
              Hedgehog Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for STK36

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STK36 (Q9NRP71, 3 ENSP000002957094) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUFUQ9UMX11, 3, ENSP000003589184EBI-863797,EBI-740595 I2D: score=2 STRING: ENSP00000358918
    FRMPD4Q14CM03, ENSP000003700574I2D: score=2 STRING: ENSP00000370057
    CDK9P507503, ENSP000003623614I2D: score=1 STRING: ENSP00000362361
    GLI1P081513, ENSP000002286824I2D: score=3 STRING: ENSP00000228682
    GLI2P100703, ENSP000003545864I2D: score=2 STRING: ENSP00000354586
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003351epithelial cilium movement IEA--
    GO:0006468protein phosphorylation TAS10806483
    GO:0007228positive regulation of hh target transcription factor activity ISS--
    GO:0007420brain development IEA--
    GO:0009791post-embryonic development ISS--

    STK36 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STK36

    3 HMDB Compounds for STK36    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STK36 gene (2 alternative transcripts): 
    NM_001243313.1  NM_015690.4  

    Unigene Cluster for STK36:

    Serine/threonine kinase 36
    Hs.471404  [show with all ESTs]
    Unigene Representative Sequence: NM_015690
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295709(uc002viu.3 uc002viv.3 uc002vix.3) ENST00000392105
    ENST00000455724 ENST00000440309 ENST00000468026 ENST00000473557 ENST00000424080
    ENST00000414413 ENST00000422778 ENST00000470568 ENST00000480709 ENST00000492486
    ENST00000486644 ENST00000473681 ENST00000419433 ENST00000462031 ENST00000392106

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate STK36 (see all 11):
    hsa-miR-4300 hsa-miR-520d-5p hsa-miR-571 hsa-miR-1236 hsa-miR-216b hsa-miR-920 hsa-miR-942 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidSTK36 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: STK36 (NM_015690)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat STK36
      Search QuantiFast Probe-based Assays in human, mouse, rat STK36

    Additional mRNA sequence: 

    AB033104.1 AF200815.1 AK022692.1 AL133630.1 BC026158.2 

    10 DOTS entries:

    DT.97842563  DT.91850845  DT.212370  DT.436243  DT.97842562  DT.121035333  DT.91646592  DT.121035325 
    DT.121035338  DT.95135132 

    Selected AceView cDNA sequences (see all 107):

    AW628961 AI363751 AW631269 CR595890 AL133630 BU620522 CK902114 BE139597 
    F30327 AI952933 F01568 BQ422453 AI479301 AA557146 AI351935 AB033104 
    AA578578 AF200815 AW003323 CF131939 BE466736 AI499649 BQ581730 BX105068 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STK36 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^
    SP1:              -     -           -     -                                                                             -           -                           
    SP2:              -     -           -     -                                                                             -           -                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                    -                                       
    SP5:                                                                                                                                                  -         

    ExUns: 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31
    SP1:                    -                                               -                                       
    SP2:                    -                                         -     -                                       
    SP3:                                                                    -                 -                     
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for STK36

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    STK36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATTCCAGA
    STK36 Expression
    About this image


    STK36 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Zeugopod Long Bone
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    STK36 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STK36 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.471404

    UniProtKB/Swiss-Prot: STK36_HUMAN, Q9NRP7
    Tissue specificity: Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult
    testis, where it is localized in germ cells

        Pathway & Disease-focused RT2 Profiler PCR Array including STK36: 
              Hedgehog Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STK36 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk361 , 5 serine/threonine kinase 36 (fused homolog, Drosophila)5
    serine/threonine kinase 361
    85.77(n)1
    84.93(a)1
      1 (38.54 cM)5
    2692091  NM_175031.31  NP_778196.21 
     746014455 
    chicken
    (Gallus gallus)
    Aves STK361 serine/threonine kinase 36, fused homolog (Drosophila) 61.05(n)
    53.92(a)
      424210  XM_422059.4  XP_422059.4 
    lizard
    (Anolis carolinensis)
    Reptilia STK366
    serine/threonine kinase 36
    52(a)
    1 ↔ 1
    1(88239891-88271328)
    zebrafish
    (Danio rerio)
    Actinopterygii 570947602   -- 74.74(n)    57094760 
    fruit fly
    (Drosophila melanogaster)
    Insecta fu3 egg chamber formation protein
    serine/threonine more
    51(a)   1 17D1   --
    worm
    (Caenorhabditis elegans)
    Secernentea air-16
    Protein AIR-1 (air-1) mRNA, complete cds
    28(a)
    many ↔ many
    V(8221410-8223587) WBGene00000098
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FMP48(YGR052W)4 Putative protein of unknown function; the authentic, more   --   7(593596-594705) 852943  NP_011566.1 
    rice
    (Oryza sativa)
    Liliopsida Os.245642 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.61(n)    AK102130.1 


    ENSEMBL Gene Tree for STK36 (if available)
    TreeFam Gene Tree for STK36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STK36 gene
    AURKA2  AURKC2  AURKB2  
    Selected SIMAP similar genes for STK36 using alignment to 7 protein entries:     STK36_HUMAN (see all proteins) (see all similar genes):
    STK32A    AURKB    DAPK3    STK33    MARK4    DAPK1
    SBK3    NEK8    AURKA    CDK18    KIAA0999    MYLK4
    PRKACA    CDK19    CAMKV    KIN27    PLK4    PRKACG

    STK36 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STK36 (see all 840)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0411874
    An ovarian papillary serous adenocarcinoma sample4--see VAR_0411872 S Y mis40--------
    VAR_0411854
    A breast pleomorphic lobular carcinoma sample4--see VAR_0411852 S C mis40--------
    VAR_0411934
    An ovarian serous carcinoma sample4--see VAR_0411932 Q K mis40--------
    rs1399285321,2
    --218918759(+) TGGATA/GGGATG 2 -- us2k10--------
    rs1927091261,2
    C--218918807(+) CGGGCA/GCGGTG 2 -- us2k10--------
    rs81795651,2
    C--218918809(+) ggcgcG/Tgtggc 2 -- us2k10--------
    rs347340991,2
    C,F--218918810(+) GCGCGG/ATGGCT 2 -- us2k13Minor allele frequency- A:0.50NA CSA 6
    rs1844651791,2
    --218918857(+) GGGTGA/GATCAT 2 -- us2k10--------
    rs349237371,2
    C--218919081(+) GTCTC-/AAAAAA 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs342376081,2
    C,F--218919226(+) TTGGGA/GCTCAT 2 -- us2k17Minor allele frequency- G:0.23NA CSA WA EA 366

    HapMap Linkage Disequilibrium report for STK36 (219536749 - 219567440 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STK36:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33891CNV Loss17666407
    nsv875862CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STK36
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607652    OMIM disorders: --

    10 diseases for STK36:    
    About MalaCards
    hydrocephalus    primary ciliary dyskinesia    basal cell carcinoma    tonsillitis
    amyotrophic lateral sclerosis    lateral sclerosis    cerebritis    thyroiditis
    prostatitis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for STK36:
    Primary ciliary dyskinesia

    STK36 for disorders           About GeneDecksing

    Genetic Association Database (GAD): STK36
    Human Genome Epidemiology (HuGE) Navigator: STK36 (1 document)

    Export disorders for STK36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STK36 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with STK36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gli regulation by the opposing activities of fused and suppressor of fused. (PubMed id 10806483)1, 2, 3 Murone M.... de Sauvage F.J. (Nat. Cell Biol. 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    5. The FU gene and its possible protein isoforms. (PubMed id 15268766)1, 9 A9sterlund T....ToftgAYrd R. (BMC Genomics 2004)
    6. Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels. (PubMed id 17054904)1, 9 Kise Y....Miki H. (Biochem. Biophys. Res. Commun. 2006)
    7. A possible role of mouse Fused (STK36) in Hedgehog signaling and Gli transcription factor regulation. (PubMed id 18600476)1, 9 Maloveryan A....Kogerman P. (J Cell Commun Signal 2007)
    8. Comparative sequence analysis of the PRKAG3 region between human and pig: evolution of repetitive sequences and potential new exons. (PubMed id 14970697)1, 9 Amarger V....Andersson L. (Cytogenet. Genome Res. 2003)
    9. Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. (PubMed id 22959728)1  ....Zheng J.G. (Neurobiol. Aging 2013)
    10. Congenital hydrocephalus in genetically engineered mice. (PubMed id 21746835)1 Vogel P....Zambrowicz B.P. (Vet. Pathol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27148 HGNC: 17209 AceView: STK36 Ensembl:ENSG00000163482 euGenes: HUgn27148
    ECgene: STK36 Kegg: 27148 H-InvDB: STK36

    (According to HUGE)
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    HUGE: KIAA1278

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STK36 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STK36 gene:
    Search GeneIP for patents involving STK36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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