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Aliases for STK35 Gene

Aliases for STK35 Gene

  • Serine/Threonine Kinase 35 2 3 5
  • Serine/Threonine-Protein Kinase 35 L1 3 4
  • CLP-36-Interacting Kinase 1 3 4
  • PDLIM1-Interacting Kinase 1 3 4
  • CLP-36 Interacting Kinase 2 3
  • EC 4 63
  • STK35L1 3 4
  • CLIK-1 3 4
  • CLIK1 3 4
  • Serine Threonine Kinase 35 Long Form 3
  • EC 2.7.11 63
  • PDIK1 4

External Ids for STK35 Gene

Previous GeneCards Identifiers for STK35 Gene

  • GC20P002070
  • GC20P002078
  • GC20P002031
  • GC20P002030

Summaries for STK35 Gene

Entrez Gene Summary for STK35 Gene

  • The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK35 Gene

STK35 (Serine/Threonine Kinase 35) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ULK3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK35 Gene

Genomics for STK35 Gene

Regulatory Elements for STK35 Gene

Enhancers for STK35 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STK35 on UCSC Golden Path with GeneCards custom track

Genomic Location for STK35 Gene

2,099,799 bp from pter
2,177,038 bp from pter
77,240 bases
Plus strand

Genomic View for STK35 Gene

Genes around STK35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK35 Gene

Proteins for STK35 Gene

  • Protein details for STK35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase 35
    Protein Accession:
    Secondary Accessions:
    • B2RBM3
    • C7ENV8
    • Q2NKW6
    • Q5T3R1
    • Q5T3R2
    • Q96AB4
    • Q9BZ06

    Protein attributes for STK35 Gene

    534 amino acids
    Molecular mass:
    58051 Da
    Quaternary structure:
    • Interacts with PDLIM1/CLP-36.
    • Association with PDLIM1 is controversial.
    • Sequence=AAI40884.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI40885.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37270.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI15590.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for STK35 Gene

Proteomics data for STK35 Gene at MOPED

Post-translational modifications for STK35 Gene

Other Protein References for STK35 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for STK35

Domains & Families for STK35 Gene

Gene Families for STK35 Gene

Protein Domains for STK35 Gene

Suggested Antigen Peptide Sequences for STK35 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK35: view

Function for STK35 Gene

Molecular function for STK35 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for STK35 Gene

genes like me logo Genes that share phenotypes with STK35: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STK35

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK35 Gene

Localization for STK35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK35 Gene

Nucleus. Nucleus, nucleolus. Cytoplasm. Note=When associated with PDLIM1, it is mostly found in cytoplasm, localized to actin stress fibers (PubMed:11973348). However, PubMed:19756140 detected STK35 only in the nucleus, and the presence of PDLIM1 had no influence on its location. {ECO:0000269 PubMed:11973348}.

Subcellular locations from

Jensen Localization Image for STK35 Gene COMPARTMENTS Subcellular localization image for STK35 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for STK35 Gene

Pathways & Interactions for STK35 Gene

SuperPathways for STK35 Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK35: view

Pathways by source for STK35 Gene

1 Qiagen pathway for STK35 Gene

Gene Ontology (GO) - Biological Process for STK35 Gene


No data available for SIGNOR curated interactions for STK35 Gene

Drugs & Compounds for STK35 Gene

(1) Drugs for STK35 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for STK35 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK35: view

Transcripts for STK35 Gene

mRNA/cDNA for STK35 Gene

Unigene Clusters for STK35 Gene

Serine/threonine kinase 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK35 Gene

No ASD Table

Relevant External Links for STK35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STK35 Gene

mRNA expression in normal human tissues for STK35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STK35 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (56.0) and Stomach (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STK35 Gene

SOURCE GeneReport for Unigene cluster for STK35 Gene Hs.100057

mRNA Expression by UniProt/SwissProt for STK35 Gene

Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with STK35: view

Protein tissue co-expression partners for STK35 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for STK35 Gene

Orthologs for STK35 Gene

This gene was present in the common ancestor of animals.

Orthologs for STK35 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STK35 35
  • 96.01 (n)
  • 98.5 (a)
STK35 36
  • 98 (a)
(Canis familiaris)
Mammalia STK35 35
  • 91.37 (n)
  • 91.37 (a)
STK35 36
  • 92 (a)
(Mus musculus)
Mammalia Stk35 35
  • 88.72 (n)
  • 87.59 (a)
Stk35 16
Stk35 36
  • 87 (a)
(Pan troglodytes)
Mammalia STK35 35
  • 99.63 (n)
  • 99.44 (a)
STK35 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Stk35 35
  • 89.29 (n)
  • 87.97 (a)
(Monodelphis domestica)
Mammalia STK35 36
  • 98 (a)
(Gallus gallus)
Aves STK35 35
  • 81.1 (n)
  • 86.86 (a)
STK35 36
  • 87 (a)
(Anolis carolinensis)
Reptilia STK35 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497495 35
  • 78.94 (n)
  • 91.36 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4235 35
(Danio rerio)
Actinopterygii LOC100536261 35
  • 71.24 (n)
  • 80.57 (a)
stk35 36
  • 72 (a)
stk35 36
  • 72 (a)
stk35l 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2540 35
(Caenorhabditis elegans)
Secernentea zyg-1 36
  • 12 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7714 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8364 36
  • 53 (a)
Species with no ortholog for STK35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK35 Gene

Gene Tree for STK35 (if available)
Gene Tree for STK35 (if available)

Paralogs for STK35 Gene

Paralogs for STK35 Gene

(4) SIMAP similar genes for STK35 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STK35: view

Variants for STK35 Gene

Sequence variations from dbSNP and Humsavar for STK35 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs16432 -- 2,148,052(-) GGCAA(-/CGGCAGTGG)ACTCA cds-indel
rs1891225 -- 2,141,357(+) GGCCC(A/G)AGAAA intron-variant
rs1891227 -- 2,117,042(+) ATGGC(C/T)CCTGA intron-variant, reference, synonymous-codon
rs2211325 -- 2,103,541(+) GGTCC(C/T)AAGAT intron-variant
rs1341808 -- 2,100,457(+) ctggg(A/G)aatag upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for STK35 Gene

Variant ID Type Subtype PubMed ID
nsv470535 CNV Gain 18288195
dgv4517n71 CNV Loss 21882294
nsv3258 CNV Insertion 18451855

Variation tolerance for STK35 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.01; 80.09% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STK35 Gene

Disorders for STK35 Gene

Relevant External Links for STK35

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STK35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK35 Gene

Publications for STK35 Gene

  1. Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein. (PMID: 11973348) Vallenius T. … Maekelae T.P. (J. Cell Sci. 2002) 2 3 4 67
  2. Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates. (PMID: 19756140) Goyal P. … Siess W. (PLoS ONE 2009) 3 23
  3. Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients. (PMID: 24811271) Kennedy R.B. … Poland G.A. (Immunogenetics 2014) 3
  4. Nuclear retention of importin I+ coordinates cell fate through changes in gene expression. (PMID: 21964068) Yasuda Y. … Yoneda Y. (EMBO J. 2012) 3
  5. STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells. (PMID: 21283756) Goyal P. … Siess W. (PLoS ONE 2011) 3

Products for STK35 Gene

Sources for STK35 Gene