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Aliases for STK33 Gene

Aliases for STK33 Gene

  • Serine/Threonine Kinase 33 2 3
  • EC 2.7.11.1 4
  • EC 2.7.11 63

External Ids for STK33 Gene

Previous GeneCards Identifiers for STK33 Gene

  • GC11M009197
  • GC11M008873
  • GC11M008372
  • GC11M008377
  • GC11M008369
  • GC11M008081

Summaries for STK33 Gene

GeneCards Summary for STK33 Gene

STK33 (Serine/Threonine Kinase 33) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is ULK3.

UniProtKB/Swiss-Prot for STK33 Gene

  • Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK33 Gene

Genomics for STK33 Gene

Regulatory Elements for STK33 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STK33 Gene

Start:
8,391,866 bp from pter
End:
8,594,289 bp from pter
Size:
202,424 bases
Orientation:
Minus strand

Genomic View for STK33 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STK33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK33 Gene

Proteins for STK33 Gene

  • Protein details for STK33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYT3-STK33_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 33
    Protein Accession:
    Q9BYT3
    Secondary Accessions:
    • Q658S6
    • Q8NEF5

    Protein attributes for STK33 Gene

    Size:
    514 amino acids
    Molecular mass:
    57831 Da
    Quaternary structure:
    • Interacts with VIME.

    Alternative splice isoforms for STK33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK33 Gene

Proteomics data for STK33 Gene at MOPED

Selected DME Specific Peptides for STK33 Gene

Post-translational modifications for STK33 Gene

Domains for STK33 Gene

Gene Families for STK33 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BYT3

UniProtKB/Swiss-Prot:

STK33_HUMAN :
  • Q9BYT3
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with STK33: view

Function for STK33 Gene

Molecular function for STK33 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.

Enzyme Numbers (IUBMB) for STK33 Gene

Gene Ontology (GO) - Molecular Function for STK33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with STK33: view
genes like me logo Genes that share phenotypes with STK33: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STK33

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for STK33 Gene

Localization for STK33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK33 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK33 Gene COMPARTMENTS Subcellular localization image for STK33 gene
Compartment Confidence
golgi apparatus 4
nucleus 4
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for STK33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with STK33: view

Pathways for STK33 Gene

SuperPathways for STK33 Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK33: view

Pathways by source for STK33 Gene

1 Qiagen pathway for STK33 Gene

Interacting Proteins for STK33 Gene

Gene Ontology (GO) - Biological Process for STK33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0046777 protein autophosphorylation ISS --
genes like me logo Genes that share ontologies with STK33: view

Transcripts for STK33 Gene

Unigene Clusters for STK33 Gene

Serine/threonine kinase 33:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STK33

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK33 Gene

No ASD Table

Relevant External Links for STK33 Gene

GeneLoc Exon Structure for
STK33
ECgene alternative splicing isoforms for
STK33

Expression for STK33 Gene

mRNA expression in normal human tissues for STK33 Gene

mRNA differential expression in normal tissues according to GTEx for STK33 Gene

This gene is overexpressed in Testis (6.1) and Pituitary (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for STK33 Gene

SOURCE GeneReport for Unigene cluster for STK33 Gene Hs.501833

mRNA Expression by UniProt/SwissProt for STK33 Gene

Q9BYT3-STK33_HUMAN
Tissue specificity: Highly expressed in testis, fetal lung and heart, followed by pituitary gland, kidney, interventricular septum, pancreas, heart, trachea, thyroid gland and uterus. Weak hybridization signals were observed in the following tissues: amygdala, aorta, esophagus, colon ascending, colon transverse, skeletal muscle, spleen, peripheral blood leukocyte, lymph node, bone marrow, placenta, prostate, liver, salivary gland, mammary gland, some tumor cell lines, fetal brain, fetal liver, fetal spleen and fetal thymus. No signal at all was detectable in RNA from tissues of the nervous system.
genes like me logo Genes that share expressions with STK33: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for STK33 Gene

Orthologs for STK33 Gene

This gene was present in the common ancestor of animals.

Orthologs for STK33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK33 35
  • 98.96 (n)
  • 98.25 (a)
STK33 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STK33 35
  • 88.1 (n)
  • 81.25 (a)
STK33 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK33 35
  • 85.27 (n)
  • 78.11 (a)
STK33 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk33 35
  • 78.5 (n)
  • 71.84 (a)
Stk33 16
Stk33 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK33 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK33 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk33 35
  • 79.22 (n)
  • 71.01 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 25 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia STK33 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk33 35
  • 68.87 (n)
  • 74.45 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18768 35
stk33 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea zyg-1 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToOne
Species with no ortholog for STK33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK33 Gene

ENSEMBL:
Gene Tree for STK33 (if available)
TreeFam:
Gene Tree for STK33 (if available)

Paralogs for STK33 Gene

Paralogs for STK33 Gene

Pseudogenes.org Pseudogenes for STK33 Gene

genes like me logo Genes that share paralogs with STK33: view

Variants for STK33 Gene

Sequence variations from dbSNP and Humsavar for STK33 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs718169 -- 8,443,571(-) TTAAT(C/T)TCTTG intron-variant
rs725502 -- 8,482,196(-) CAGCT(A/G)TGACA intron-variant, upstream-variant-2KB
rs726007 -- 8,444,416(-) aacat(G/T)cttgt intron-variant
rs726008 -- 8,444,394(-) TAAAC(A/G)AGATT intron-variant
rs749263 -- 8,392,323(-) TGCAC(A/G)TGGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for STK33 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
esv2751035 CNV Loss 17911159
esv2667808 CNV Deletion 23128226
nsv519052 CNV Loss 19592680
esv32551 CNV Loss 17666407
esv2657808 CNV Deletion 23128226
nsv471747 CNV Loss 16327809
nsv896983 CNV Loss 21882294

Relevant External Links for STK33 Gene

HapMap Linkage Disequilibrium report
STK33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK33 Gene

Disorders for STK33 Gene

Relevant External Links for STK33

Genetic Association Database (GAD)
STK33
Human Genome Epidemiology (HuGE) Navigator
STK33
genes like me logo Genes that share disorders with STK33: view

No data available for UniProtKB/Swiss-Prot for STK33 Gene

Publications for STK33 Gene

  1. A novel serine/threonine kinase gene, STK33, on human chromosome 11p15.3. (PMID: 11738831) Mujica A.O. … Schmidt E.R. (Gene 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Differential expression pattern of the novel serine/threonine kinase, STK33, in mice and men. (PMID: 16176263) Mujica A.O. … Schmidt E.R. (FEBS J. 2005) 3 4
  5. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. (PMID: 19079261) Willer C.J. … Hirschhorn J.N. (Nat. Genet. 2009) 3 48

Products for STK33 Gene

  • Addgene plasmids for STK33

Sources for STK33 Gene

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