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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STK33 Gene

protein-coding   GIFtS: 53
GCID: GC11M008369

serine/threonine kinase 33

 Explore 6 diseases affiliated with
STK33 via our new
 Human Malady Compendium 
Biological research products
for STK33
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Serine/Threonine Kinase 331 2
Serine/Threonine-Protein Kinase 332
EC 2.7.11.13
EC 2.7.118

External Ids:    HGNC: 145681   Entrez Gene: 659752   Ensembl: ENSG000001304137   OMIM: 6076705   UniProtKB: Q9BYT33   

Export aliases for STK33 gene to outside databases

Previous GC identifers: GC11M009197 GC11M008873 GC11M008372 GC11M008377 GC11M008081


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: STK33_HUMAN, Q9BYT3
Function: Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior
of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival
of KRAS-dependent AML cell lines




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STK33 gene promoter:
         GR   ATF-2   GR-beta   FAC1   POU2F1   FOXO4   POU2F1a   c-Myb   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK33 promoter sequence
   Search SABiosciences Chromatin IP Primers for STK33

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.3

STK33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK33 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M008369:  view genomic region     (about GC identifiers)

Start:
8,413,418 bp from pter      End:
8,615,836 bp from pter
Size:
202,419 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STK33_HUMAN, Q9BYT3 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 33  
Size: 514 amino acids; 57831 Da
Subunit: Interacts with VIME (By similarity)
Subcellular location: Cytoplasm, perinuclear region (By similarity)
Secondary accessions: Q658S6 Q8NEF5
Alternative splicing: 2 isoforms:  Q9BYT3-1   Q9BYT3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STK33: NX_Q9BYT3

Post-translational modifications:

  • Autophosphorylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BYT3

  • 2 DME Specific Peptides for STK33 (Q9BYT3)
     RDLKLEN  IVHRDLK 

    STK33 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_112168.1  
    ENSEMBL proteins: 
     ENSP00000416750   ENSP00000320754   ENSP00000379905   ENSP00000351743   ENSP00000415688  
     ENSP00000436418   ENSP00000436905   ENSP00000391362   ENSP00000411510   ENSP00000403599  
     ENSP00000397569   ENSP00000397874   ENSP00000432822   ENSP00000379906  

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    Novus Biologicals STK33 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for STK33

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0048471perinuclear region of cytoplasm IEA--


    STK33 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for STK33


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    STK33 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9BYT3

    ProtoNet protein and cluster: Q9BYT3

    UniProtKB/Swiss-Prot: STK33_HUMAN, Q9BYT3
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 1 protein kinase domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: STK33_HUMAN, Q9BYT3
    Function: Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior
    of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival
    of KRAS-dependent AML cell lines
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

    Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11

    miRNA
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    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate STK33 (see all 31):
    hsa-miR-15a hsa-miR-106a hsa-miR-301a hsa-miR-944 hsa-miR-885-5p hsa-miR-519a hsa-miR-424 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidSTK33 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK33

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--


    STK33 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for STK33:
     Decreased Salmonella enterica   Decreased substrate adherent c  Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sweet Taste Signaling
    Sperm Motility0.36

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for STK33
        Sperm Motility


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STK33

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for STK33 (Q9BYT33 ENSP000003207544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1DP296923I2D: score=1 
    HDAC3ENSP000003029674STRING: ENSP00000302967
    GLYCTKENSP000003891754STRING: ENSP00000389175
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046777protein autophosphorylation ISS--


    STK33 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STK33
    Search CenterWatch for drugs/clinical trials and news about STK33 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STK33 gene: 
    NM_030906.2  

    Unigene Cluster for STK33:

    Serine/threonine kinase 33
    Hs.501833  [show with all ESTs]
    Unigene Representative Sequence: AK122808
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000473980 ENST00000486305 ENST00000447869(uc001mgi.1) ENST00000315204(uc001mgj.1)
    ENST00000396672(uc001mgk.1 uc010rbn.1) ENST00000358872(uc001mgl.3)
    ENST00000444064 ENST00000534493 ENST00000526517(uc009yfp.3) ENST00000524760
    ENST00000418597 ENST00000422559 ENST00000457885 ENST00000532336 ENST00000431279
    ENST00000454443 ENST00000526360 ENST00000396673

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STK33
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate STK33 (see all 31):
    hsa-miR-15a hsa-miR-106a hsa-miR-301a hsa-miR-944 hsa-miR-885-5p hsa-miR-519a hsa-miR-424 hsa-miR-93
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    Additional cDNA sequence: 

    AJ303380.2 AK092720.1 AK093251.1 AK122808.1 AK293193.1 AK310754.1 AL833011.1 BC031231.1 

    11 DOTS entries:

    DT.100774894  DT.106654  DT.91658602  DT.100774896  DT.95100842  DT.99927657  DT.120683471  DT.86847843 
    DT.91743568  DT.100774347  DT.92066347 

    24/89 AceView cDNA sequences (see all 89):

    N67346 BE327549 AJ303380 AW118625 AI267885 BI830742 BE218817 NM_030906 
    CB306028 AI818743 AL041049 AI818734 AA297313 BM975518 CA312615 AA886440 
    AI818733 BE670014 BE504022 BE326215 BI464341 AA626278 BG197564 AA767746 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STK33 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTTCGTGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    STK33 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See STK33 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STK33

    SOURCE GeneReport for Unigene cluster: Hs.501833

    UniProtKB/Swiss-Prot: STK33_HUMAN, Q9BYT3
    Tissue specificity: Highly expressed in testis, fetal lung and heart, followed by pituitary gland, kidney,
    interventricular septum, pancreas, heart, trachea, thyroid gland and uterus. Weak hybridization signals were observed
    in the following tissues: amygdala, aorta, esophagus, colon ascending, colon transverse, skeletal muscle, spleen,
    peripheral blood leukocyte, lymph node, bone marrow, placenta, prostate, liver, salivary gland, mammary gland, some
    tumor cell lines, fetal brain, fetal liver, fetal spleen and fetal thymus. No signal at all was detectable in RNA from
    tissues of the nervous system

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK33

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for STK33 gene from 3/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia STK336
    --
    62(a)
    1 ↔ 1
    GL343294.1(1579587-1614728)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420182302   -- 72.53(n)    142018230 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.187682 Transcribed sequence with weak similarity to protein more 72.57(n)    BQ617398.1 


    ENSEMBL Gene Tree for STK33 (if available)
    TreeFam Gene Tree for STK33 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STK33 gene
    PDIK1L2  ULK12  STK362  ULK22  ULK32  STK352  
    18/67 SIMAP similar genes for STK33 using alignment to 12 protein entries:     STK33_HUMAN (see all proteins) (see all similar genes):
    BRSK2    STK36    MARK4    HUNK    CAMK1D    NUAK1
    RPS6KA1    MAPKAPK3    CAMK1    PLK4    SIK3    MAPKAPK5
    RPS6KA4    PRKAA1    MELK    CAMK1G    MARK2    CAMKV

    STK33 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STK33
    PGOHUM00000236668


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3413 NCBI SNPs in STK33 are shown (see all 3413    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386670211,2
    --8413135(+) CTTTAC/TGAAGG 1 -- ds50010--------
    rs1428674691,2
    --8413150(+) AGCAAC/TTGCAA 1 -- ds50010--------
    rs1469953721,2
    --8413205(+) TTCAAC/TCAGTT 1 -- ds50010--------
    rs1381042891,2
    --8413332(+) TACCAC/TTGCAG 1 -- ds50010--------
    rs734020671,2
    C,F,--8413360(+) AATTTG/CCATAA 1 -- ds50014Minor allele frequency- C:0.14WA CSA NA 242
    rs1877117811,2
    --8413396(+) ACCTCC/TTGTTA 1 -- ds50010--------
    rs734020681,2
    C,F,--8413407(+) ACATAA/CANNNN 1 -- ds50014Minor allele frequency- C:0.15WA CSA NA 242
    rs1435320581,2
    --8413528(+) AAGCTA/GTCTTA 1 -- ut310--------
    rs1926260721,2
    --8413561(+) TCTCAC/TGAACA 1 -- ut310--------
    rs1821141591,2
    --8413567(+) GAACAC/GATGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for STK33 (8413418 - 8615836 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for STK33
         2 CNVs: 9175 6946
         1 Indel: 10870
    Human Gene Mutation Database (HGMD): STK33

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STK33
    DNA2.0 Custom Variant and Variant Library Synthesis for STK33

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    STK33 for disorders           About GeneDecksing

    OMIM gene information: 607670    OMIM disorders: --

    6 diseases for STK33:    About MalaCards
    asthma    obesity    thyroiditis    malaria
    prostatitis    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: STK33 (2 documents)

    Export disorders for STK33 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STK33 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with STK33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel serine/threonine kinase gene, STK33, on human chromosome 11p15.3. (PubMed id 11738831)1, 2, 3 Mujica A.O.... Schmidt E.R. (2001)
    2. STk33 kinase activity is non-essential in KRAS-dependent cancer cells. (PubMed id 21742770)1, 2 Babij C.... Dussault I. (2011)
    3. Differential expression pattern of the novel serine/threonine kinase, STK33, in mice and men. (PubMed id 16176263)1, 2 Mujica A.O....Schmidt E.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Targeting of KRAS mutant tumors by HSP90 inhibitors in volves degradation of STK33. (PubMed id 22451720)1 Azoitei N....Scholl C. (2012)
    7. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1 Speliotes E.K....Loos R.J. (2010)
    10. Evaluating the discriminative power of multi-trait ge netic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1 Fontaine-Bisson B....Franks P.W. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65975 HGNC: 14568 AceView: STK33 Ensembl:ENSG00000130413 euGenes: HUgn65975
    ECgene: STK33 H-InvDB: STK33

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STK33 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STK33 gene:
    Search GeneIP for patents involving STK33

    GeneCards and IP:
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