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Aliases for STK32C Gene

Aliases for STK32C Gene

  • Serine/Threonine Kinase 32C 2 3 5
  • Yet Another Novel Kinase 3 3 4
  • EC 2.7.11.1 4 63
  • YANK3 3 4
  • PKE 3 4
  • Testicular Tissue Protein Li 187 3
  • PKE Protein Kinase 3
  • EC 2.7.11 63

External Ids for STK32C Gene

Previous GeneCards Identifiers for STK32C Gene

  • GC10M133456
  • GC10M133870
  • GC10M134020
  • GC10M127572

Summaries for STK32C Gene

Entrez Gene Summary for STK32C Gene

  • The protein encoded by this gene is a member of the serine/threonine protein kinase family. It is thought that this family member is functional in brain due to its high expression levels there. DNA methylation differences have been found in this gene in monozygotic twins that are discordant for adolescent depression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for STK32C Gene

STK32C (Serine/Threonine Kinase 32C) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK32B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK32C Gene

Genomics for STK32C Gene

Regulatory Elements for STK32C Gene

Promoters for STK32C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STK32C on UCSC Golden Path with GeneCards custom track

Genomic Location for STK32C Gene

Chromosome:
10
Start:
132,207,489 bp from pter
End:
132,332,256 bp from pter
Size:
124,768 bases
Orientation:
Minus strand

Genomic View for STK32C Gene

Genes around STK32C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK32C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK32C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK32C Gene

Proteins for STK32C Gene

  • Protein details for STK32C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UX6-ST32C_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 32C
    Protein Accession:
    Q86UX6
    Secondary Accessions:
    • Q5T0Q5
    • Q86UE1

    Protein attributes for STK32C Gene

    Size:
    486 amino acids
    Molecular mass:
    54994 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STK32C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK32C Gene

Proteomics data for STK32C Gene at MOPED

Selected DME Specific Peptides for STK32C Gene

Post-translational modifications for STK32C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for STK32C Gene

Gene Families for STK32C Gene

Suggested Antigen Peptide Sequences for STK32C Gene

Graphical View of Domain Structure for InterPro Entry

Q86UX6

UniProtKB/Swiss-Prot:

ST32C_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK32C: view

Function for STK32C Gene

Molecular function for STK32C Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for STK32C Gene

Gene Ontology (GO) - Molecular Function for STK32C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with STK32C: view
genes like me logo Genes that share phenotypes with STK32C: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STK32C

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STK32C Gene

Localization for STK32C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK32C Gene COMPARTMENTS Subcellular localization image for STK32C gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for STK32C Gene

Pathways & Interactions for STK32C Gene

SuperPathways for STK32C Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK32C: view

Pathways by source for STK32C Gene

1 Qiagen pathway for STK32C Gene

Gene Ontology (GO) - Biological Process for STK32C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with STK32C: view

No data available for SIGNOR curated interactions for STK32C Gene

Drugs & Compounds for STK32C Gene

(2) Drugs for STK32C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for STK32C Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK32C: view

Transcripts for STK32C Gene

Unigene Clusters for STK32C Gene

Serine/threonine kinase 32C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK32C Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - -
SP2: - - - - - - - - -
SP3: - - - - - - -
SP4: -
SP5:
SP6: - -
SP7: - - - -
SP8: - - - -

Relevant External Links for STK32C Gene

GeneLoc Exon Structure for
STK32C
ECgene alternative splicing isoforms for
STK32C

Expression for STK32C Gene

mRNA expression in normal human tissues for STK32C Gene

mRNA differential expression in normal tissues according to GTEx for STK32C Gene

This gene is overexpressed in Brain - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for STK32C Gene

This gene is overexpressed in Liver (41.2), Frontal cortex (9.5), Peripheral blood mononuclear cells (6.7), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STK32C Gene



SOURCE GeneReport for Unigene cluster for STK32C Gene Hs.469002

genes like me logo Genes that share expression patterns with STK32C: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for STK32C Gene

Orthologs for STK32C Gene

This gene was present in the common ancestor of animals.

Orthologs for STK32C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK32C 36
  • 99 (a)
OneToOne
STK32C 35
  • 99.31 (n)
  • 99.38 (a)
cow
(Bos Taurus)
Mammalia STK32C 36
  • 92 (a)
OneToOne
STK32C 35
  • 90.44 (n)
  • 92.65 (a)
dog
(Canis familiaris)
Mammalia STK32C 35
  • 89.06 (n)
  • 91.73 (a)
STK32C 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk32c 16
Stk32c 35
  • 87.52 (n)
  • 91.36 (a)
Stk32c 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK32C 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK32C 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk32c 35
  • 87.72 (n)
  • 91.77 (a)
chicken
(Gallus gallus)
Aves STK32C 35
  • 80.85 (n)
  • 82.69 (a)
STK32C 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK32C 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk32c 35
  • 71.45 (n)
  • 79.06 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01072625.1 36
  • 88 (a)
OneToMany
CABZ01092745.1 36
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32944 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M03C11.1 36
  • 42 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12751 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for STK32C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK32C Gene

ENSEMBL:
Gene Tree for STK32C (if available)
TreeFam:
Gene Tree for STK32C (if available)

Paralogs for STK32C Gene

Paralogs for STK32C Gene

genes like me logo Genes that share paralogs with STK32C: view

Variants for STK32C Gene

Sequence variations from dbSNP and Humsavar for STK32C Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs15711 -- 132,207,688(+) CCTCC(A/G)GGCTG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs902629 -- 132,225,211(+) AGCCC(A/G)GGGGC intron-variant
rs954042 -- 132,323,951(+) TGGCA(C/G)TTAAT intron-variant
rs1038804 -- 132,212,943(+) GTGTG(C/T)GGGAA intron-variant
rs1046577 -- 132,207,645(-) GCAGC(A/G)CAGGC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for STK32C Gene

Variant ID Type Subtype PubMed ID
nsv896120 CNV Loss 21882294
nsv896122 CNV Loss 21882294
nsv832030 CNV Loss 17160897
dgv839n71 CNV Loss 21882294
dgv841n71 CNV Loss 21882294
nsv896140 CNV Loss 21882294
nsv896141 CNV Loss 21882294
dgv843n71 CNV Loss 21882294
dgv844n71 CNV Loss 21882294
dgv845n71 CNV Loss 21882294
esv272068 CNV Insertion 20981092
esv2661595 CNV Deletion 23128226
esv2743637 CNV Deletion 23290073
nsv896149 CNV Loss 21882294
nsv470975 CNV Gain 18288195
nsv896150 CNV Loss 21882294
esv2743638 CNV Deletion 23290073
esv2743639 CNV Deletion 23290073
esv2109501 CNV Deletion 18987734
esv2743640 CNV Deletion 23290073
esv2676420 CNV Deletion 23128226
esv2743642 CNV Deletion 23290073
esv2743643 CNV Deletion 23290073
esv2743644 CNV Deletion 23290073
nsv467490 CNV Loss 19166990
nsv896151 CNV Loss 21882294
esv2743645 CNV Deletion 23290073
esv2743646 CNV Deletion 23290073
nsv24619 CNV Insertion 16902084
esv1920267 CNV Deletion 18987734
dgv135e201 CNV Deletion 23290073
esv2676196 CNV Deletion 23128226
esv1302998 CNV Insertion 17803354
esv2743649 CNV Deletion 23290073
esv2490403 CNV Deletion 19546169
esv2743650 CNV Deletion 23290073
esv2743651 CNV Deletion 23290073
esv2743653 CNV Deletion 23290073
esv1144814 CNV Insertion 17803354

Variation tolerance for STK32C Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.00; 84.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK32C Gene

HapMap Linkage Disequilibrium report
STK32C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK32C Gene

Disorders for STK32C Gene

Relevant External Links for STK32C

Genetic Association Database (GAD)
STK32C
Human Genome Epidemiology (HuGE) Navigator
STK32C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK32C

No disorders were found for STK32C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK32C Gene

Publications for STK32C Gene

  1. Replication of recently described type 2 diabetes gene variants in a South Indian population. (PMID: 20580033) Chidambaram M. … Mohan V. (Metab. Clin. Exp. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3

Products for STK32C Gene

Sources for STK32C Gene

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