STK32C Gene
protein-coding GIFtS: 49
GCID: GC10M134020
|
|
serine/threonine kinase 32C
| |
Aliases
for STK32C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine/Threonine Kinase 32C1 2 | | RP11-140A10.12 | | PKE1 2 3 | | PKE Protein Kinase2 | | YANK31 2 3 | | Protein Kinase (PKE)2 | | Yet Another Novel Kinase 32 3 | | Serine/Threonine-Protein Kinase 32C2 | | EC 2.7.11.13 8 | | EC 2.7.118 | | MGC236651 | | |
Export aliases for STK32C gene to outside databasesPrevious GC identifers: GC10M133456 GC10M133870 GC10M127572 |
Summaries
for STK32C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for STK32C:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. The specific function ofthis kinase is not known. (provided by RefSeq, Jul 2008)
|
Genomic Views
for STK32C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008818.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STK32C gene promoter:
C/EBPbeta Pbx1a Pax-5 Nkx2-5 Cdc5 Tal-1beta E47 SRY SEF-1 (1) STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for STK32C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK32C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.3 Ensembl cytogenetic band: 10q26.3 HGNC cytogenetic band: 10q26.3STK32C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M134020: view genomic region
(about GC identifiers)
Start:
|
134,020,994 bp from pter |
End:
|
134,145,353 bp from pter |
Size:
|
124,360 bases |
Orientation:
|
minus strand |
|
Proteins
for STK32C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ST32C_HUMAN, Q86UX6 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase 32C Size: 486 amino acids; 54994 Da
Cofactor: Magnesium (By similarity)
Secondary accessions: Q5T0Q5 Q86UE1Alternative splicing: 2 isoforms: Q86UX6-1 Q86UX6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for STK32C: NX_Q86UX6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86UX6
4/7 DME Specific Peptides for STK32C (Q86UX6) (see all 7)
STK32C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775846.2
ENSEMBL proteins: ENSP00000357611 ENSP00000298630 ENSP00000432415 ENSP00000357609 ENSP00000357608 ENSP00000389112 ENSP00000357614
Human Recombinant Protein Products:
STK32C Antibody Products:
Assay Products for STK32C: |
Protein
Domains /
Families
for STK32C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STK32C for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86UX6ProtoNet protein and cluster: Q86UX6 UniProtKB/Swiss-Prot: ST32C_HUMAN, Q86UX6Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for STK32C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ST32C_HUMAN, Q86UX6Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK32C (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK32C (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: STK32C (NM_173575) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STK32C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK32C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK32C |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
STK32C for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for STK32C:
|
Pathways & Interactions
for STK32C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STK32C
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for STK32C (Q86UX63 ENSP000002986304) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for STK32C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STK32C
3 HMDB Compounds for STK32C About this table
Search CenterWatch for drugs/clinical trials and news about STK32C / ST32C
|
Transcripts
for STK32C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STK32C gene: NM_173575.2 Unigene Cluster for STK32C: Serine/threonine kinase 32C Hs.469002 [show with all ESTs]Unigene Representative Sequence: AK0983668 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000478542(uc001llb.2 uc009ybd.1) ENST00000368622(uc001lld.1)
ENST00000298630(uc001lle.1) ENST00000462160(uc001llc.1) ENST00000368620
ENST00000368619 ENST00000456004 ENST00000368625(uc010quu.1 uc009ybc.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK32C (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK32C (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STK32C (NM_173575) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STK32C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK32C |
Additional cDNA sequence: AK057849.1 AK098366.1 AK302102.1 AK308956.1 AK310725.1 AY098866.1 BC015792.1 BC045760.1 9 DOTS entries: DT.308457 DT.95160926 DT.100735092 DT.100738255 DT.97763010 DT.100022358 DT.121241542 DT.40119107 DT.95160925 24/91 AceView cDNA sequences (see all 91): F07785 NM_173575 AA770113 AI867824 BM827134 CA454976 BM666731 CR595271 BX401698 CA432719 AW014700 BX342288 BM720428 BE220639 AW236108 CB155747 AY098866 AK057849 BI915617 AW467235 AI014704 BX416707 BX390945 BI257653
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for STK32C (see all 8) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for STK32C
|
Expression
for STK32C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STK32C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTTGGGGTA
About this image
See STK32C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STK32C
SOURCE GeneReport for Unigene cluster: Hs.469002
SABiosciences Custom PCR Arrays for STK32C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STK32C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STK32C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STK32C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STK32C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK32C |
Orthologs
for STK32C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for STK32C gene from 5/19 species (see all 19) About this table
ENSEMBL Gene Tree for STK32C (if available)
TreeFam Gene Tree for STK32C (if available) |
Paralogs
for STK32C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STK32C gene
- STK32B2 STK32A2
18/41 SIMAP similar genes for STK32C using alignment to 7 protein entries: ST32C_HUMAN (see all proteins)
(see all similar genes):STK32A STK32B DKFZp762M113 KIN27 SGK2 PRKACB
PRKACA AKT2 DKFZp564L2416 PRKY RPS6KA3 PRKCE
AKT1 CHEK2 PRKACG RPS6KA6 PRKX CDC42BPA
STK32C for paralogs About GeneDecksing
|
Genomic Variants
for STK32C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STK32C (134020994 - 134145353 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for STK32C
1 CNV: 4717
2 Indels: 44696 44697 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STK32C |
|
Disorders
/ Diseases
for STK32C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STK32C for disorders About GeneDecksing
2  diseases for STK32C: About MalaCardsendophthalmitis astigmatism
Human Genome Epidemiology (HuGE) Navigator: STK32C (1 document)
Export disorders for STK32C gene to outside databases
|
Publications
for STK32C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STK32C gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with STK32C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- The protein kinase complement of the human genome. (PubMed id 12471243)1, 2 Manning G.... Sudarsanam S. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- Replication of recently described type 2 diabetes gen e variants in a South Indian population. (PubMed id 20580033)1 Chidambaram M....Mohan V. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
|
External Searches for STK32C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STK32C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STK32C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STK32C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STK32C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STK32C gene:
Search GeneIP for patents involving STK32C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STK32C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for STK32C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STK32C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STK32C | | | OriGene Protein Over-expression Lysate for STK32C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STK32C | | OriGene 3'-UTR Clone for STK32C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK32C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK32C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for STK32C | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for STK32C | | OriGene Custom Protein Services for STK32C | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STK32C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STK32C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK32C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STK32C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STK32C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STK32C |
| |
 |  |  |  | |
| | | | Search Tocris compounds for STK32C |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | STK32C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK32C |
|  |  |  | | | | Search ThermoFisher Antibodies for STK32C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK32C |
|
|
|
|
