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Aliases for STK32C Gene

Aliases for STK32C Gene

  • Serine/Threonine Kinase 32C 2 3 5
  • Yet Another Novel Kinase 3 3 4
  • EC 2.7.11.1 4 61
  • YANK3 3 4
  • PKE 3 4
  • Serine/Threonine-Protein Kinase 32C 3
  • Testicular Tissue Protein Li 187 3
  • PKE Protein Kinase 3
  • EC 2.7.11 61

External Ids for STK32C Gene

Previous GeneCards Identifiers for STK32C Gene

  • GC10M133456
  • GC10M133870
  • GC10M134020
  • GC10M127572

Summaries for STK32C Gene

Entrez Gene Summary for STK32C Gene

  • The protein encoded by this gene is a member of the serine/threonine protein kinase family. It is thought that this family member is functional in brain due to its high expression levels there. DNA methylation differences have been found in this gene in monozygotic twins that are discordant for adolescent depression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for STK32C Gene

STK32C (Serine/Threonine Kinase 32C) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK32B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK32C Gene

Genomics for STK32C Gene

Regulatory Elements for STK32C Gene

Enhancers for STK32C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F132229 1.1 FANTOM5 Ensembl ENCODE 27.8 +100.4 100412 4.9 CTCF SMARCA4 POLR2A NRF1 SP2 MAX FOXP2 STK32C C10orf91 LOC105378568 LRRC27 JAKMIP3 LOC105378567 GC10M132318
GH10F132255 0.7 Ensembl 42.7 +75.8 75756 2.6 GATAD2A KLF1 MAZ NR2F1 ZIC2 ZFHX2 GLIS1 NR2F6 ZNF600 EGR2 STK32C GC10M132318 LOC105378567
GH10F132328 1.1 ENCODE 23.8 +1.2 1160 4.9 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP3 STK32C LRRC27
GH10F132392 1.7 FANTOM5 Ensembl ENCODE 13.5 -76.1 -76147 32.2 HDGF PKNOX1 ARID4B SIN3A YBX1 DMAP1 ZNF207 ZNF548 FOS DEK TUBGCP2 ENSG00000235245 C10orf91 STK32C LOC105378568 PWWP2B LRRC27 LINC01164 CALY DPYSL4
GH10F132319 1.2 Ensembl ENCODE 18.4 +11.9 11919 2.3 ARID4B SIN3A FOS JUNB TBX21 MAFF MIER3 SMARCA4 MYNN HMBOX1 STK32C LRRC27 GC10M132318
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STK32C on UCSC Golden Path with GeneCards custom track

Promoters for STK32C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000007693 956 3801 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP3

Genomic Location for STK32C Gene

Chromosome:
10
Start:
132,207,489 bp from pter
End:
132,332,256 bp from pter
Size:
124,768 bases
Orientation:
Minus strand

Genomic View for STK32C Gene

Genes around STK32C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK32C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK32C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK32C Gene

Proteins for STK32C Gene

  • Protein details for STK32C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UX6-ST32C_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 32C
    Protein Accession:
    Q86UX6
    Secondary Accessions:
    • Q5T0Q5
    • Q86UE1

    Protein attributes for STK32C Gene

    Size:
    486 amino acids
    Molecular mass:
    54994 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STK32C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK32C Gene

Selected DME Specific Peptides for STK32C Gene

Q86UX6:
  • KMYAMKYMNKQ
  • GKGSFGKV
  • FQILRAI
  • CDPTFELEEMILES
  • IHRDVKPDN
  • ILRAIGKGSFGKVCIV
  • LGGDLRYH

Post-translational modifications for STK32C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for STK32C Gene

Gene Families for STK32C Gene

Protein Domains for STK32C Gene

Suggested Antigen Peptide Sequences for STK32C Gene

Graphical View of Domain Structure for InterPro Entry

Q86UX6

UniProtKB/Swiss-Prot:

ST32C_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK32C: view

Function for STK32C Gene

Molecular function for STK32C Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for STK32C Gene

Gene Ontology (GO) - Molecular Function for STK32C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with STK32C: view
genes like me logo Genes that share phenotypes with STK32C: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STK32C

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STK32C Gene

Localization for STK32C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK32C gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for STK32C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
genes like me logo Genes that share ontologies with STK32C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for STK32C Gene

Pathways & Interactions for STK32C Gene

SuperPathways for STK32C Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK32C: view

Pathways by source for STK32C Gene

1 Qiagen pathway for STK32C Gene

Gene Ontology (GO) - Biological Process for STK32C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with STK32C: view

No data available for SIGNOR curated interactions for STK32C Gene

Drugs & Compounds for STK32C Gene

(2) Drugs for STK32C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for STK32C Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK32C: view

Transcripts for STK32C Gene

Unigene Clusters for STK32C Gene

Serine/threonine kinase 32C:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK32C Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - -
SP2: - - - - - - - - -
SP3: - - - - - - -
SP4: -
SP5:
SP6: - -
SP7: - - - -
SP8: - - - -

Relevant External Links for STK32C Gene

GeneLoc Exon Structure for
STK32C
ECgene alternative splicing isoforms for
STK32C

Expression for STK32C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STK32C Gene

mRNA differential expression in normal tissues according to GTEx for STK32C Gene

This gene is overexpressed in Brain - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for STK32C Gene

This gene is overexpressed in Liver (41.2), Frontal cortex (9.5), Peripheral blood mononuclear cells (6.7), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STK32C Gene



NURSA nuclear receptor signaling pathways regulating expression of STK32C Gene:

STK32C

SOURCE GeneReport for Unigene cluster for STK32C Gene:

Hs.469002
genes like me logo Genes that share expression patterns with STK32C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for STK32C Gene

Orthologs for STK32C Gene

This gene was present in the common ancestor of animals.

Orthologs for STK32C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK32C 34 35
  • 99.31 (n)
cow
(Bos Taurus)
Mammalia STK32C 34 35
  • 90.44 (n)
dog
(Canis familiaris)
Mammalia STK32C 34 35
  • 89.06 (n)
rat
(Rattus norvegicus)
Mammalia Stk32c 34
  • 87.72 (n)
mouse
(Mus musculus)
Mammalia Stk32c 34 16 35
  • 87.52 (n)
oppossum
(Monodelphis domestica)
Mammalia STK32C 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK32C 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK32C 34 35
  • 80.85 (n)
lizard
(Anolis carolinensis)
Reptilia STK32C 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk32c 34
  • 71.45 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01072625.1 35
  • 88 (a)
OneToMany
CABZ01092745.1 35
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32944 35
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M03C11.1 35
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12751 34
Species where no ortholog for STK32C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK32C Gene

ENSEMBL:
Gene Tree for STK32C (if available)
TreeFam:
Gene Tree for STK32C (if available)

Paralogs for STK32C Gene

Variants for STK32C Gene

Sequence variations from dbSNP and Humsavar for STK32C Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs764558009 A colorectal cancer sample 132,222,765(+) GCAGA(C/T)GGCCT nc-transcript-variant, reference, missense
rs1000535 -- 132,238,150(+) GGCAC(A/G)GGGCA intron-variant
rs1000536 -- 132,238,236(+) TACAC(A/G)GCAGG intron-variant
rs10128535 -- 132,293,117(+) GCGCG(G/T)GCATG intron-variant
rs1038799 -- 132,234,026(-) CTCAT(C/T)GGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK32C Gene

Variant ID Type Subtype PubMed ID
esv3547105 CNV deletion 23714750
esv3547103 CNV deletion 23714750
esv3547102 CNV deletion 23714750
esv3402854 CNV insertion 20981092
esv3345984 CNV duplication 20981092
esv2761642 CNV gain 21179565
esv2743653 CNV deletion 23290073
esv2743651 CNV deletion 23290073
esv2743650 CNV deletion 23290073
esv2743649 CNV deletion 23290073
esv2743646 CNV deletion 23290073
esv2743645 CNV deletion 23290073
esv2743644 CNV deletion 23290073
esv2743643 CNV deletion 23290073
esv2743642 CNV deletion 23290073
esv2743640 CNV deletion 23290073
esv2743639 CNV deletion 23290073
esv2743638 CNV deletion 23290073
esv2743637 CNV deletion 23290073
esv2676420 CNV deletion 23128226
esv2676196 CNV deletion 23128226
esv2661595 CNV deletion 23128226
esv2490403 CNV deletion 19546169
esv2109501 CNV deletion 18987734
esv1920267 CNV deletion 18987734
esv1302998 CNV insertion 17803354
esv1144814 CNV insertion 17803354
dgv553n106 CNV duplication 24896259
dgv116e201 CNV deletion 23290073
nsv951888 CNV deletion 24416366
nsv951887 CNV deletion 24416366
nsv951886 CNV deletion 24416366
nsv951885 CNV deletion 24416366
nsv832030 CNV loss 17160897
nsv552505 CNV loss 21841781
nsv552504 CNV loss 21841781
nsv552502 CNV loss 21841781
nsv470975 CNV gain 18288195
nsv467490 CNV loss 19166990
nsv24619 CNV insertion 16902084
nsv1154007 CNV deletion 26484159
nsv1152012 CNV duplication 26484159
nsv1148296 CNV deletion 26484159
nsv1131011 CNV deletion 24896259
nsv1122574 CNV deletion 24896259
nsv1075822 CNV duplication 25765185
nsv1069526 CNV deletion 25765185
nsv1069525 CNV deletion 25765185
nsv1054934 CNV gain 25217958
nsv1054569 CNV gain 25217958
nsv1051555 CNV gain 25217958
esv3624956 CNV gain 21293372

Variation tolerance for STK32C Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.00; 84.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK32C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK32C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK32C Gene

Disorders for STK32C Gene

Relevant External Links for STK32C

Genetic Association Database (GAD)
STK32C
Human Genome Epidemiology (HuGE) Navigator
STK32C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK32C

No disorders were found for STK32C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK32C Gene

Publications for STK32C Gene

  1. Replication of recently described type 2 diabetes gene variants in a South Indian population. (PMID: 20580033) Chidambaram M. … Mohan V. (Metab. Clin. Exp. 2010) 3 46 64
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for STK32C Gene

Sources for STK32C Gene

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