STK32B Gene
protein-coding GIFtS : 50
GCID: GC04 P005053
serine/threonine kinase 32B
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Aliasesfor STK32B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Serine/Threonine Kinase 32B 1 2 Yet Another Novel Kinase 22 3 YANK21 2 3 EC 2.7.11.13 8 HSA2508391 2 Gene For Serine/Threonine Protein Kinase2 STK321 2 Serine/Threonine-Protein Kinase 32B2 STKG61 2 EC 2.7.118
Export aliases for STK32B gene to outside databases Previous GC identifers: GC04P005120 GC04P005171 GC04P004990
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Summariesfor STK32B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor STK32B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_006051.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the STK32B gene promoter: STAT5B ISGF-3 Lmo2 Tal-1beta E47 FOXL1 HNF-4alpha1 Evi-1 ITF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for STK32B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat STK32B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4p16.2 Ensembl cytogenetic band: 4p16.2 HGNC cytogenetic band: 4p16 STK32B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P005053: view genomic region
(about GC identifiers )
Start:
5,053,169 bp from pter
End:
5,502,725 bp from pter
Size:
449,557 bases
Orientation:
plus strand
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Proteinsfor STK32B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ST32B_HUMAN, Q9NY57 (See
protein sequence )Recommended Name: Serine/threonine-protein kinase 32B Size : 414 amino acids; 47883 Da
Cofactor : Magnesium (By similarity)
Sequence caution : Sequence=AAQ88719.1; Type=Erroneous initiation;
Secondary accessions : Q6UXH3 Q8IY14Alternative splicing : 2 isoforms : Q9NY57-1 Q9NY57-2 (It is unsure whether Met-1 or Met-3 is the initiator. No experimental confirmation available)Explore the universe of human proteins at neXtProt for STK32B: NX_Q9NY57 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NY57 4/9 DME Specific Peptides for STK32B (Q9NY57 ) (see all 9 )STK32B Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_060871.1 ENSEMBL proteins: ENSP00000282908 ENSP00000422820 ENSP00000423209 ENSP00000420984 Human Recombinant Protein Products: STK32B Antibody Products: Assay Products for STK32B:
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Protein
Domains / Familiesfor STK32B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
STK32B for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9NY57 ProtoNet protein and cluster: Q9NY57
UniProtKB/Swiss-Prot: ST32B_HUMAN, Q9NY57 Similarity : Belongs to the protein kinase superfamily. Ser/Thr protein kinase familySimilarity : Contains 1 protein kinase domain
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Functionfor STK32B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ST32B_HUMAN, Q9NY57 Catalytic activity : ATP + a protein = ADP + a phosphoproteinEnzyme Numbers (IUBMB): EC 2.7.11.1 1 2 EC 2.7.11 2
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for STK32B (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for STK32B (see all 5 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: STK32B (NM_018401 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STK32B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat STK32B
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK32B
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004674 protein serine/threonine kinase activity
IEA -- GO:0005524 ATP binding
IEA -- GO:0046872 metal ion binding
IEA --
STK32B for ontologies About GeneDecksing 3 GenomeRNAi human phenotypes for STK32B :Animal Models: Mouse knock-out Stk32b tm1Lex for STK32B 1 MGI phenotypic allele for Stk32b (no phenotypes)
STK32B for phenotypes About GeneDecksing
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Pathways & Interactionsfor STK32B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STK32B
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Drugs & Compoundsfor STK32B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for STK32B 3 HMDB Compounds for STK32B About this table Search CenterWatch for drugs/clinical trials and news about STK32B / ST32B
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Transcriptsfor STK32B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for STK32B gene: NM_018401.1 Unigene Cluster for STK32B:
Serine/threonine kinase 32B Hs.133062 [show with all ESTs ] Unigene Representative Sequence: AY358353 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000282908 (uc003gih.1 uc010ida.1 ) ENST00000512018 ENST00000512636 ENST00000510398 ENST00000513705 ENST00000505508 ENST00000511959 ENST00000508728 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for STK32B (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for STK32B (see all 5 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: STK32B (NM_018401 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STK32B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat STK32B
Additional cDNA sequence: AJ250839.1 AK055597.1 AK292696.1 AK302915.1 AK313846.1 AL832436.1 AY358353.1 BC020281.1 BC024977.1 BC038238.1 BC069203.1
6 DOTS entries : DT.40114006 DT.95181775
DT.99965328 DT.121242090 DT.300030 DT.99938234 11 AceView cDNA sequences :
AA960957 BQ068792 BX100338 BM908009 BM152207 AI001155 BC069203 AY358353 BC038238 AJ250839 NM_018401 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for STK32B About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b SP1 :     -               -   -     -               SP2 :     -     -           -   -     -               SP3 :         -           -   -     -               SP4 :                                      
ECgene alternative splicing isoforms for STK32B
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Expression for STK32B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section STK32B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAAAACCTTT
About this image STK32B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See STK32B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for STK32B SOURCE GeneReport for Unigene cluster: Hs.133062 SABiosciences Custom PCR Arrays for STK32B Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for STK32BBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat STK32B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat STK32B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat STK32B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK32B
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Orthologsfor STK32B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for STK32B gene from 4/18 species (see all 18 ) About this table
ENSEMBL Gene Tree for STK32B (if available)TreeFam Gene Tree for STK32B (if available)
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Paralogsfor STK32B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for STK32B gene STK32C 2 STK32A 2 18/35 SIMAP similar genes for STK32B using alignment to 3 protein entries: ST32B_HUMAN (see all proteins )
(see all similar genes ):DKFZp762M113 STK32A STK32C SGK2 PRKACB KIN27 RPS6KA6 CHEK2 DKFZp564L2416 DKFZp781N0293 PRKACA STK36 ADRBK1 AKT1 AKT3 PRKAA1 PRKACG PRKCH
STK32B for paralogs About GeneDecksing
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Genomic Variantsfor STK32B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 15 variations for STK32B 8 CNVs : 80158 80157 91894 53082 91898 51416 8995 91896 5 Indels : 91897 68639 91895 27671 27674 2 Inversions : 43702 59791 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing STK32B
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Disorders
/ Diseasesfor STK32B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
STK32B for disorders About GeneDecksing 3 diseases for STK32B : About MalaCards weyers acrodental dysostosis ellis-van creveld syndrome dysostosis 1 disease from the University of Copenhagen DISEASES database for STK32B :Ellis-Van Creveld syndrome Human Genome Epidemiology (HuGE) Navigator: STK32B (4 documents) Export disorders for STK32B gene to outside databases
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Publicationsfor STK32B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for STK32B gene, integrated from 9 sources (see all 13 ): (articles sorted by number of sources associating them with STK32B) Utopia : connect your pdf to the dynamic world of online information
Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis. (PubMed id 10700184) 1 , 2 , 3 Ruiz-Perez V.L....Goodship J. (2000) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) The protein kinase complement of the human genome. (PubMed id 12471243) 1 , 2 Manning G.... Sudarsanam S. (2002) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Association between genes on chromosome 4p16 and non- syndromic oral clefts in four populations. (PubMed id 20087401) 1 Ingersoll R.G....Beaty T.H. (2010) Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061) 1 Trynka G....Wijmenga C. (2009) Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. (PubMed id 19389651) 1 Smith J.G....Newton-Cheh C. (2009) Long interspersed nuclear element-1 (LINE1)-mediated deletion of EVC, EVC2, C4orf6, and STK32B in Ellis-van Creveld syndrome with borderline intelligence. (PubMed id 18454448) 1 Temtamy S.A....Ruiz-Perez V.L. (2008) Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846) 2 Greenman C.... Stratton M.R. (2007)
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External Searches for STK32B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing STK32B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing STK32B gene
(According to HUGE )
About This Section --
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Specialized Databases showing STK32B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for STK32B Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for STK32B gene: Search GeneIP for patents involving STK32B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor STK32B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for STK32B OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for STK32B OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for STK32B OriGene Protein Over-expression Lysate for STK32B Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for STK32B OriGene 3'-UTR Clone for STK32B OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for STK32B OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for STK32B Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for STK32B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for STK32B OriGene Custom Protein Services for STK32B OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STK32B QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing STK32B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat STK32B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat STK32B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat STK32B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat STK32B
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STK32B Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK32B
ThermoFisher Antibodies for STK32B
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat STK32B
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