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Aliases for STK32B Gene

Aliases for STK32B Gene

  • Serine/Threonine Kinase 32B 2 3 5
  • Yet Another Novel Kinase 2 3 4
  • EC 2.7.11.1 4 61
  • YANK2 3 4
  • Gene For Serine/Threonine Protein Kinase 3
  • Serine/Threonine-Protein Kinase 32B 3
  • HSA250839 3
  • EC 2.7.11 61
  • STK32 3
  • STKG6 3

External Ids for STK32B Gene

Previous GeneCards Identifiers for STK32B Gene

  • GC04P005120
  • GC04P005171
  • GC04P004990

Summaries for STK32B Gene

Entrez Gene Summary for STK32B Gene

  • This gene encodes a serine-threonine protein kinase. Serine-threonine kinases transfer phosphate molecules to the oxygen atoms of serine and threonine. A genomic deletion affecting this gene has been associated with Ellis-van Creveld syndrome, an autosomal recessive skeletal dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

GeneCards Summary for STK32B Gene

STK32B (Serine/Threonine Kinase 32B) is a Protein Coding gene. Diseases associated with STK32B include Ellis-Van Creveld Syndrome. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK32A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK32B Gene

Genomics for STK32B Gene

Regulatory Elements for STK32B Gene

Enhancers for STK32B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F005003 1 ENCODE 11.4 -47.6 -47583 0.2 ATF1 PKNOX1 ARNT ELK1 GATA2 NCOA1 SMARCB1 CREB3 MBD2 MEF2D STK32B GC04M005011 GC04P004939
GH04F005164 0.8 Ensembl ENCODE 10.2 +114.6 114619 1.7 CTCF ZNF316 JUND KDM1A MAFK STK32B LOC105374362 GC04P005121
GH04F005018 0.6 ENCODE 12.3 -32.5 -32478 0.5 BCOR CBX1 HDAC2 ADNP ZMYM3 KDM1A CYTL1 STK32B GC04M005011
GH04F005206 0.6 ENCODE 10.5 +155.4 155358 0.8 BHLHE40 ZFHX2 JUND SMARCA4 FOS NFE2 MYC EGR2 NFE2L2 STK32B LOC105374362 GC04P005298
GH04F005785 0.5 ENCODE 9.7 +734.6 734639 1.7 CTCF POLR2A FOS STK32B CRMP1 GC04P005776 GC04P005811
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STK32B on UCSC Golden Path with GeneCards custom track

Promoters for STK32B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001235532 289 2201 RAD21 GLIS2 EGR2 ZNF263 SP3 ZNF654 REST TFDP1 ZFP69B ZNF610

Genomic Location for STK32B Gene

Chromosome:
4
Start:
5,051,211 bp from pter
End:
5,500,998 bp from pter
Size:
449,788 bases
Orientation:
Plus strand

Genomic View for STK32B Gene

Genes around STK32B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK32B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK32B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK32B Gene

Proteins for STK32B Gene

  • Protein details for STK32B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY57-ST32B_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 32B
    Protein Accession:
    Q9NY57
    Secondary Accessions:
    • Q6UXH3
    • Q8IY14

    Protein attributes for STK32B Gene

    Size:
    414 amino acids
    Molecular mass:
    47883 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88719.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STK32B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK32B Gene

Selected DME Specific Peptides for STK32B Gene

Q9NY57:
  • DIKPDNI
  • KMYAMKYMNKQ
  • GKGSFGKV
  • HRDIKPDN
  • FQILRAI
  • CDPTFELEEMILES
  • KPPVFDE
  • ILRAIGKGSFGKVCIV
  • LGGDLRYH

Post-translational modifications for STK32B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for STK32B Gene

Gene Families for STK32B Gene

Protein Domains for STK32B Gene

Suggested Antigen Peptide Sequences for STK32B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NY57

UniProtKB/Swiss-Prot:

ST32B_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK32B: view

Function for STK32B Gene

Molecular function for STK32B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for STK32B Gene

Gene Ontology (GO) - Molecular Function for STK32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with STK32B: view
genes like me logo Genes that share phenotypes with STK32B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STK32B

miRNA for STK32B Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK32B Gene

Localization for STK32B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK32B gene
Compartment Confidence
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for STK32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
genes like me logo Genes that share ontologies with STK32B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for STK32B Gene

Pathways & Interactions for STK32B Gene

SuperPathways for STK32B Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK32B: view

Pathways by source for STK32B Gene

1 Qiagen pathway for STK32B Gene

Gene Ontology (GO) - Biological Process for STK32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with STK32B: view

No data available for SIGNOR curated interactions for STK32B Gene

Drugs & Compounds for STK32B Gene

(2) Drugs for STK32B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for STK32B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK32B: view

Transcripts for STK32B Gene

mRNA/cDNA for STK32B Gene

Unigene Clusters for STK32B Gene

Serine/threonine kinase 32B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK32B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4:

Relevant External Links for STK32B Gene

GeneLoc Exon Structure for
STK32B
ECgene alternative splicing isoforms for
STK32B

Expression for STK32B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STK32B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of STK32B Gene:

STK32B

SOURCE GeneReport for Unigene cluster for STK32B Gene:

Hs.133062
genes like me logo Genes that share expression patterns with STK32B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for STK32B Gene

Orthologs for STK32B Gene

This gene was present in the common ancestor of animals.

Orthologs for STK32B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK32B 34 35
  • 94.39 (n)
cow
(Bos Taurus)
Mammalia STK32B 34 35
  • 90.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STK32B 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK32B 34 35
  • 89.69 (n)
oppossum
(Monodelphis domestica)
Mammalia STK32B 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk32b 34 16 35
  • 86.88 (n)
rat
(Rattus norvegicus)
Mammalia Stk32b 34
  • 86.47 (n)
chicken
(Gallus gallus)
Aves STK32B 34 35
  • 79.23 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia stk32b 34
  • 75.33 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330817 34
  • 67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000477 34
  • 59.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32944 34 35
  • 58.93 (n)
worm
(Caenorhabditis elegans)
Secernentea M03C11.1 34 35
  • 53.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
Species where no ortholog for STK32B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK32B Gene

ENSEMBL:
Gene Tree for STK32B (if available)
TreeFam:
Gene Tree for STK32B (if available)

Paralogs for STK32B Gene

Paralogs for STK32B Gene

genes like me logo Genes that share paralogs with STK32B: view

Variants for STK32B Gene

Sequence variations from dbSNP and Humsavar for STK32B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_041166 A metastatic melanoma sample
rs796052163 Likely benign 5,416,859(+) ACATT(A/G)CAGAC intron-variant, reference, missense
rs10000042 -- 5,235,425(+) AATGG(C/T)GTGCC intron-variant
rs10000062 -- 5,253,017(+) CTTGT(C/G)CTTGC intron-variant
rs10000083 -- 5,348,125(+) tgtta(A/G)gagag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK32B Gene

Variant ID Type Subtype PubMed ID
nsv999245 CNV loss 25217958
nsv997905 CNV gain 25217958
nsv997889 CNV gain 25217958
nsv954406 CNV deletion 24416366
nsv949774 CNV duplication 24416366
nsv593489 CNV loss 21841781
nsv593488 CNV loss 21841781
nsv593485 CNV loss 21841781
nsv593484 CNV loss 21841781
nsv593483 CNV loss 21841781
nsv593482 CNV loss 21841781
nsv593481 CNV gain 21841781
nsv593480 CNV loss 21841781
nsv593479 CNV gain 21841781
nsv527989 CNV gain 19592680
nsv527143 CNV loss 19592680
nsv521349 CNV loss 19592680
nsv520417 CNV loss 19592680
nsv471805 CNV loss 16327809
nsv461181 CNV loss 19166990
nsv1149536 CNV deletion 26484159
nsv1144071 CNV deletion 24896259
nsv1144070 CNV deletion 24896259
nsv1136811 CNV deletion 24896259
nsv1128028 CNV deletion 24896259
nsv1124883 CNV duplication 24896259
nsv1117057 CNV deletion 24896259
nsv1117056 CNV deletion 24896259
nsv1109577 CNV deletion 24896259
nsv1074142 CNV deletion 25765185
nsv1074141 CNV deletion 25765185
nsv1074140 CNV deletion 25765185
nsv1011885 CNV loss 25217958
nsv1010013 CNV gain 25217958
nsv1001085 CNV loss 25217958
esv9538 OTHER inversion 19470904
esv3893864 CNV gain 25118596
esv3893863 CNV loss 25118596
esv3599485 CNV loss 21293372
esv3599484 CNV loss 21293372
esv3599483 CNV loss 21293372
esv3599482 CNV loss 21293372
esv3599481 CNV loss 21293372
esv3599480 CNV loss 21293372
esv3599478 CNV loss 21293372
esv3599477 CNV loss 21293372
esv3599476 CNV loss 21293372
esv3599472 CNV loss 21293372
esv3569267 CNV loss 25503493
esv3569264 CNV loss 25503493
esv3563305 CNV deletion 23714750
esv34196 OTHER inversion 12058347
esv3269 OTHER inversion 18987735
esv2762403 CNV loss 21179565
esv2760874 CNV loss 21179565
esv2752049 CNV loss 17911159
esv2726975 CNV deletion 23290073
esv2726974 CNV deletion 23290073
esv2726972 CNV deletion 23290073
esv2726971 CNV deletion 23290073
esv2678136 CNV deletion 23128226
esv2668377 CNV deletion 23128226
esv2663309 CNV deletion 23128226
esv2657644 CNV deletion 23128226
esv23244 CNV loss 19812545
esv1790419 CNV deletion 17803354
esv1526304 CNV deletion 17803354
esv1007800 CNV deletion 20482838
dgv8931n54 CNV loss 21841781
dgv639n27 CNV loss 19166990
dgv5094n100 CNV gain 25217958
dgv1455e212 CNV loss 25503493
dgv1454e212 CNV loss 25503493
dgv1453e212 CNV loss 25503493
dgv134n6 CNV deletion 16902084

Variation tolerance for STK32B Gene

Residual Variation Intolerance Score: 11.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.46; 88.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK32B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK32B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK32B Gene

Disorders for STK32B Gene

MalaCards: The human disease database

(1) MalaCards diseases for STK32B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ellis-van creveld syndrome
  • chondroectodermal dysplasia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for STK32B

Genetic Association Database (GAD)
STK32B
Human Genome Epidemiology (HuGE) Navigator
STK32B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK32B
genes like me logo Genes that share disorders with STK32B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK32B Gene

Publications for STK32B Gene

  1. Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis. (PMID: 10700184) Ruiz-Perez V.L. … Goodship J. (Nat. Genet. 2000) 2 3 4 64
  2. Association between genes on chromosome 4p16 and non-syndromic oral clefts in four populations. (PMID: 20087401) Ingersoll R.G. … Beaty T.H. (Eur. J. Hum. Genet. 2010) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  5. Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. (PMID: 19389651) Smith J.G. … Newton-Cheh C. (Heart Rhythm 2009) 3 46 64

Products for STK32B Gene

Sources for STK32B Gene

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