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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STK32B Gene

protein-coding   GIFtS: 50
GCID: GC04P005053

serine/threonine kinase 32B

 Explore 3 diseases affiliated with
STK32B via our new
 Human Malady Compendium 
Biological research products
for STK32B
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Serine/Threonine Kinase 32B1 2     Yet Another Novel Kinase 22 3
YANK21 2 3     EC 2.7.11.13 8
HSA2508391 2     Gene For Serine/Threonine Protein Kinase2
STK321 2     Serine/Threonine-Protein Kinase 32B2
STKG61 2     EC 2.7.118

External Ids:    HGNC: 142171   Entrez Gene: 553512   Ensembl: ENSG000001529537   UniProtKB: Q9NY573   

Export aliases for STK32B gene to outside databases

Previous GC identifers: GC04P005120 GC04P005171 GC04P004990


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006051.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STK32B gene promoter:
         STAT5B   ISGF-3   Lmo2   Tal-1beta   E47   FOXL1   HNF-4alpha1   Evi-1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK32B promoter sequence
   Search SABiosciences Chromatin IP Primers for STK32B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK32B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.2   Ensembl cytogenetic band:  4p16.2   HGNC cytogenetic band: 4p16

STK32B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK32B gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P005053:  view genomic region     (about GC identifiers)

Start:
5,053,169 bp from pter      End:
5,502,725 bp from pter
Size:
449,557 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ST32B_HUMAN, Q9NY57 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 32B  
Size: 414 amino acids; 47883 Da
Cofactor: Magnesium (By similarity)
Sequence caution: Sequence=AAQ88719.1; Type=Erroneous initiation;
Secondary accessions: Q6UXH3 Q8IY14
Alternative splicing: 2 isoforms:  Q9NY57-1   Q9NY57-2   (It is unsure whether Met-1 or Met-3 is the initiator. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STK32B: NX_Q9NY57

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NY57

  • 4/9 DME Specific Peptides for STK32B (Q9NY57) (see all 9)
     DIKPDNI  FQILRAI  KPPVFDE  HRDIKPDN 

    STK32B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060871.1  
    ENSEMBL proteins: 
     ENSP00000282908   ENSP00000422820   ENSP00000423209   ENSP00000420984  

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    Uscn Proteins for STK32B


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    Uscn ELISAs and CLIAs for STK32B


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    STK32B for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9NY57

    ProtoNet protein and cluster: Q9NY57

    UniProtKB/Swiss-Prot: ST32B_HUMAN, Q9NY57
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ST32B_HUMAN, Q9NY57
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate STK32B (see all 10):
    hsa-miR-3671 hsa-miR-3184 hsa-miR-27a hsa-miR-4267 hsa-miR-423-5p hsa-miR-512-5p hsa-miR-544 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidSTK32B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STK32B (see all 7)
    OriGene shRNA RFP: STK32B
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STK32B

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for STK32B

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK32B (see all 3)
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    Search LifeMap BioReagents cell lines for STK32B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK32B

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0046872metal ion binding IEA--


    STK32B for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for STK32B:
     Decreased mitotic index  Decreased substrate adherent c  High actin ratio cells 

    Animal Models:
         Mouse knock-out Stk32btm1Lex for STK32B
         1 MGI phenotypic allele for Stk32b (no phenotypes)

    STK32B for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STK32B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STK32B

    3 HMDB Compounds for STK32B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Search CenterWatch for drugs/clinical trials and news about STK32B / ST32B 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STK32B gene: 
    NM_018401.1  

    Unigene Cluster for STK32B:

    Serine/threonine kinase 32B
    Hs.133062  [show with all ESTs]
    Unigene Representative Sequence: AY358353
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282908(uc003gih.1 uc010ida.1) ENST00000512018 ENST00000512636
    ENST00000510398 ENST00000513705 ENST00000505508 ENST00000511959 ENST00000508728


    miRNA
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    OriGene 3'-UTR Clone: STK32B
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STK32B
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate STK32B (see all 10):
    hsa-miR-3671 hsa-miR-3184 hsa-miR-27a hsa-miR-4267 hsa-miR-423-5p hsa-miR-512-5p hsa-miR-544 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidSTK32B 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    OriGene shRNA RFP: STK32B
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK32B (see all 3)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STK32B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STK32B

    Additional cDNA sequence: 

    AJ250839.1 AK055597.1 AK292696.1 AK302915.1 AK313846.1 AL832436.1 AY358353.1 BC020281.1 
    BC024977.1 BC038238.1 BC069203.1 

    6 DOTS entries:

    DT.40114006  DT.95181775  DT.99965328  DT.121242090  DT.300030  DT.99938234 

    11 AceView cDNA sequences:

    AA960957 BQ068792 BX100338 BM908009 BM152207 AI001155 BC069203 AY358353 
    BC038238 AJ250839 NM_018401 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for STK32B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:              -                                         -     -           -                                       
    SP2:              -           -                             -     -           -                                       
    SP3:                          -                             -     -           -                                       
    SP4:                                                                                                                  


    ECgene alternative splicing isoforms for STK32B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STK32B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAAACCTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    STK32B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

    See STK32B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STK32B

    SOURCE GeneReport for Unigene cluster: Hs.133062
        SABiosciences Custom PCR Arrays for STK32B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK32B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for STK32B gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves STK32B1 serine/threonine kinase 32B 79.23(n)
    88.16(a)
      422850  XM_420796.2  XP_420796.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003308171 serine/threonine-protein kinase 32B-like 66.83(n)
    67.09(a)
      100330817  XM_002666081.2  XP_002666127.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG329441 CG32944 58.94(n)
    56.15(a)
      40560  NM_001043201.3  NP_001036666.2 
    worm
    (Caenorhabditis elegans)
    Secernentea M03C11.11 Protein M03C11.1 53.84(n)
    47.23(a)
      176456  NM_066893.2  NP_499294.1 


    ENSEMBL Gene Tree for STK32B (if available)
    TreeFam Gene Tree for STK32B (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STK32B gene
    STK32C2  STK32A2  
    18/35 SIMAP similar genes for STK32B using alignment to 3 protein entries:     ST32B_HUMAN (see all proteins) (see all similar genes):
    DKFZp762M113    STK32A    STK32C    SGK2    PRKACB    KIN27
    RPS6KA6    CHEK2    DKFZp564L2416    DKFZp781N0293    PRKACA    STK36
    ADRBK1    AKT1    AKT3    PRKAA1    PRKACG    PRKCH

    STK32B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 15 variations for STK32B
         8 CNVs: 80158 80157 91894 53082 91898 51416 8995 91896
         5 Indels: 91897 68639 91895 27671 27674
         2 Inversions: 43702 59791
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STK32B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    STK32B for disorders           About GeneDecksing

    3 diseases for STK32B:    About MalaCards
    weyers acrodental dysostosis    ellis-van creveld syndrome    dysostosis

    1 disease from the University of Copenhagen DISEASES database for STK32B:
    Ellis-Van Creveld syndrome
    Human Genome Epidemiology (HuGE) Navigator: STK32B (4 documents)

    Export disorders for STK32B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STK32B gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with STK32B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis. (PubMed id 10700184)1, 2, 3 Ruiz-Perez V.L....Goodship J. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. The protein kinase complement of the human genome. (PubMed id 12471243)1, 2 Manning G.... Sudarsanam S. (2002)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. Association between genes on chromosome 4p16 and non- syndromic oral clefts in four populations. (PubMed id 20087401)1 Ingersoll R.G....Beaty T.H. (2010)
    7. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
    8. Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. (PubMed id 19389651)1 Smith J.G....Newton-Cheh C. (2009)
    9. Long interspersed nuclear element-1 (LINE1)-mediated deletion of EVC, EVC2, C4orf6, and STK32B in Ellis-van Creveld syndrome with borderline intelligence. (PubMed id 18454448)1 Temtamy S.A....Ruiz-Perez V.L. (2008)
    10. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55351 HGNC: 14217 AceView: STK32B Ensembl:ENSG00000152953 euGenes: HUgn55351
    ECgene: STK32B H-InvDB: STK32B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STK32B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STK32B gene:
    Search GeneIP for patents involving STK32B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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