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Aliases for STK32B Gene

Aliases for STK32B Gene

  • Serine/Threonine Kinase 32B 2 3
  • Yet Another Novel Kinase 2 3 4
  • EC 2.7.11.1 4 64
  • YANK2 3 4
  • Gene For Serine/Threonine Protein Kinase 3
  • Serine/Threonine-Protein Kinase 32B 3
  • HSA250839 3
  • EC 2.7.11 64
  • STK32 3
  • STKG6 3

External Ids for STK32B Gene

Summaries for STK32B Gene

GeneCards Summary for STK32B Gene

STK32B (Serine/Threonine Kinase 32B) is a Protein Coding gene. Diseases associated with STK32B include weyers acrodental dysostosis and ellis-van creveld syndrome. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is STK32A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK32B Gene

Genomics for STK32B Gene

Genomic Location for STK32B Gene

Start:
5,051,442 bp from pter
End:
5,501,001 bp from pter
Size:
449,560 bases
Orientation:
Plus strand

Genomic View for STK32B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STK32B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK32B Gene

Regulatory Elements for STK32B Gene

Proteins for STK32B Gene

  • Protein details for STK32B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY57-ST32B_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 32B
    Protein Accession:
    Q9NY57
    Secondary Accessions:
    • Q6UXH3
    • Q8IY14

    Protein attributes for STK32B Gene

    Size:
    414 amino acids
    Molecular mass:
    47883 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88719.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STK32B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK32B Gene

Proteomics data for STK32B Gene at MOPED

Post-translational modifications for STK32B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STK32B Gene

Domains for STK32B Gene

UniProtKB/Swiss-Prot:

ST32B_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q9NY57
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.:
    • Q9NY57
genes like me logo Genes that share domains with STK32B: view

Function for STK32B Gene

Molecular function for STK32B Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for STK32B Gene

Gene Ontology (GO) - Molecular Function for STK32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with STK32B: view

Phenotypes for STK32B Gene

genes like me logo Genes that share phenotypes with STK32B: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for STK32B Gene

Localization for STK32B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK32B Gene COMPARTMENTS Subcellular localization image for STK32B gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for STK32B Gene

Pathways for STK32B Gene

SuperPathways for STK32B Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK32B: view

Pathways by source for STK32B Gene

1 Qiagen pathway for STK32B Gene

Interacting Proteins for STK32B Gene

Gene Ontology (GO) - Biological Process for STK32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with STK32B: view

Compounds for STK32B Gene

(3) HMDB Compounds for STK32B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with STK32B: view

Transcripts for STK32B Gene

mRNA/cDNA for STK32B Gene

Unigene Clusters for STK32B Gene

Serine/threonine kinase 32B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK32B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4:

Relevant External Links for STK32B Gene

GeneLoc Exon Structure for
STK32B
ECgene alternative splicing isoforms for
STK32B

Expression for STK32B Gene

mRNA expression in normal human tissues for STK32B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for STK32B Gene Hs.133062

genes like me logo Genes that share expressions with STK32B: view

Orthologs for STK32B Gene

This gene was present in the common ancestor of animals.

Orthologs for STK32B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK32B 36
  • 94.39 (n)
  • 92.44 (a)
STK32B 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STK32B 36
  • 90.7 (n)
  • 95.12 (a)
STK32B 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK32B 36
  • 89.69 (n)
  • 92.75 (a)
STK32B 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk32b 36
  • 86.88 (n)
  • 92.03 (a)
Stk32b 16
Stk32b 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK32B 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK32B 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk32b 36
  • 86.47 (n)
  • 90.58 (a)
chicken
(Gallus gallus)
Aves STK32B 36
  • 79.23 (n)
  • 88.16 (a)
STK32B 37
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk32b 36
  • 75.33 (n)
  • 82.84 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100330817 36
  • 67 (n)
  • 67.09 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000477 36
  • 59.29 (n)
  • 54.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32944 36
  • 58.93 (n)
  • 56.08 (a)
CG32944 37
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M03C11.1 36
  • 53.84 (n)
  • 47.23 (a)
M03C11.1 37
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
OneToMany
Species with no ortholog for STK32B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK32B Gene

ENSEMBL:
Gene Tree for STK32B (if available)
TreeFam:
Gene Tree for STK32B (if available)

Paralogs for STK32B Gene

Paralogs for STK32B Gene

genes like me logo Genes that share paralogs with STK32B: view

Variants for STK32B Gene

Sequence variations from dbSNP and Humsavar for STK32B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs17183 -- 5,346,316(+) TGTAC(A/G)TGAAG intron-variant
rs81607 -- 5,419,002(-) CCGAT(C/T)CCCAA intron-variant
rs168985 -- 5,416,812(-) TTAGC(A/G)TGGGC intron-variant
rs168986 -- 5,415,614(-) AAGCT(G/T)AAGTC intron-variant
rs168987 -- 5,433,130(-) TCATT(G/T)TTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK32B Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
esv1526304 CNV Deletion 17803354
nsv521349 CNV Loss 19592680
esv9538 OTHER Inversion 19470904
nsv878513 CNV Gain 21882294
nsv878514 CNV Loss 21882294
esv2726971 CNV Deletion 23290073
nsv527143 CNV Loss 19592680
esv2726972 CNV Deletion 23290073
nsv471805 CNV Loss 16327809
esv1007800 CNV Deletion 20482838
dgv134n6 CNV Loss 16902084
esv2726974 CNV Deletion 23290073
esv2752049 CNV Loss 17911159
esv2726975 CNV Deletion 23290073
nsv878515 CNV Gain 21882294
esv2668377 CNV Deletion 23128226
esv3269 OTHER Inversion 18987735
esv2678136 CNV Deletion 23128226
esv1790419 CNV Deletion 17803354
esv2657644 CNV Deletion 23128226
esv23244 CNV Loss 19812545
dgv639n27 CNV Loss 19166990
nsv878516 CNV Gain 21882294
nsv527989 CNV Gain 19592680
esv2663309 CNV Deletion 23128226
nsv878517 CNV Gain 21882294
nsv878518 CNV Gain 21882294
nsv878519 CNV Loss 21882294
nsv520417 CNV Loss 19592680
nsv461181 CNV Loss 19166990

Relevant External Links for STK32B Gene

HapMap Linkage Disequilibrium report
STK32B

Disorders for STK32B Gene

(1) University of Copenhagen DISEASES for STK32B Gene

Relevant External Links for STK32B

Genetic Association Database (GAD)
STK32B
Human Genome Epidemiology (HuGE) Navigator
STK32B
genes like me logo Genes that share disorders with STK32B: view

No data available for UniProtKB/Swiss-Prot for STK32B Gene

Publications for STK32B Gene

  1. Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis. (PMID: 10700184) Ruiz-Perez V.L. … Goodship J. (Nat. Genet. 2000) 2 3 4
  2. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 49

Products for STK32B Gene

Sources for STK32B Gene

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