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STK32B Gene

protein-coding   GIFtS: 53
GCID: GC04P005053

Serine/Threonine Kinase 32B

  See STK32B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section


Aliases
Serine/Threonine Kinase 32B1 2     STK322
Yet Another Novel Kinase 22 3     STKG62
YANK22 3     Gene For Serine/Threonine Protein Kinase2
EC 2.7.11.13 8     Serine/Threonine-Protein Kinase 32B2
HSA2508392     EC 2.7.118

External Ids:    HGNC: 142171   Entrez Gene: 553512   Ensembl: ENSG000001529537   UniProtKB: Q9NY573   

Export aliases for STK32B gene to outside databases

Previous GC identifiers: GC04P005120 GC04P005171 GC04P004990


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section


GeneCards Summary for STK32B Gene:
STK32B (serine/threonine kinase 32B) is a protein-coding gene. Diseases associated with STK32B include ellis-van creveld syndrome. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is STK32C.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STK32B gene promoter:
         STAT5B   ISGF-3   Lmo2   Tal-1beta   E47   FOXL1   HNF-4alpha1   Evi-1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK32B promoter sequence
   Search Chromatin IP Primers for STK32B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK32B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.2   Ensembl cytogenetic band:  4p16.2   HGNC cytogenetic band: 4p16

STK32B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK32B gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P005053:  view genomic region     (about GC identifiers)

Start:
5,053,169 bp from pter      End:
5,502,725 bp from pter
Size:
449,557 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section


UniProtKB/Swiss-Prot: ST32B_HUMAN, Q9NY57 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 32B  
Size: 414 amino acids; 47883 Da
Cofactor: Magnesium (By similarity)
Sequence caution: Sequence=AAQ88719.1; Type=Erroneous initiation;
Secondary accessions: Q6UXH3 Q8IY14
Alternative splicing: 2 isoforms:  Q9NY57-1   Q9NY57-2   (It is unsure whether Met-1 or Met-3 is the initiator. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STK32B: NX_Q9NY57

Explore proteomics data for STK32B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for STK32B (Q9NY57) (see all 9)
     DIKPDNI  FQILRAI  KPPVFDE  HRDIKPDN 


    See STK32B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060871.1  
    ENSEMBL proteins: 
     ENSP00000282908   ENSP00000422820   ENSP00000423209   ENSP00000420984  

    STK32B Human Recombinant Protein Products:

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    OriGene Custom Protein Services for STK32B
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    Novus Biologicals STK32B Proteins
    Novus Biologicals STK32B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STK32B

     
    Search eBioscience for Proteins for STK32B 

     
    Search GeneTex for Proteins for STK32B 

     
    antibodies-online proteins for STK32B (6 products) 

     
    antibodies-online peptides for STK32B

    STK32B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for STK32B
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    ThermoFisher Antibody for STK32B

     
    GeneTex Antibodies for STK32B:  
                        STK32B Antibodies
    antibodies-online antibodies for STK32B (18 products) 

    STK32B Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for STK32B
    Cloud-Clone Corp. CLIAs for STK32B
    Search eBioscience for ELISAs for STK32B 
    antibodies-online kits for STK32B (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine kinase 32B
    YANK family
    Other AGC kinases

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9NY57

    ProtoNet protein and cluster: Q9NY57

    UniProtKB/Swiss-Prot: ST32B_HUMAN, Q9NY57
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with STK32B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section


    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST32B_HUMAN, Q9NY57
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with STK32B           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for STK32B:
     Decreased mitotic index  Decreased substrate adherent c  High actin ratio cells 

         1 MGI phenotypic allele for Stk32b (no phenotypes)

    Find genes that share phenotypes with STK32B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Stk32btm1Lex for STK32B

       genOway: Develop your customized and physiologically relevant rodent model for STK32B

        Taconic Biosciences Mouse Models for STK32B:  
                        TF3448 - Stk32b

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for STK32B

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat STK32B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK32B (see all 10):
    hsa-miR-3671 hsa-miR-3184 hsa-miR-27a hsa-miR-4267 hsa-miR-423-5p hsa-miR-512-5p hsa-miR-544 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidSTK32B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STK32B
    Predesigned siRNA for gene silencing in human, mouse, rat STK32B

    Clone
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    OriGene clones in human, mouse for STK32B (see all 10)
    OriGene ORF clones in mouse, rat for STK32B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STK32B (NM_018401)
    Sino Biological Human cDNA Clone for STK32B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK32B
    Addgene plasmids for STK32B 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for STK32B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK32B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section


    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion2
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section




    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STK32B
        Sperm Motility



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STK32B
    Interactions:

        Search GeneGlobe Interaction Network for STK32B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for STK32B (ENSP000002829084) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JAZF1ENSP000002839284STRING: ENSP00000283928
    MAF1ENSP000003186044STRING: ENSP00000318604
    MAPKAP1ENSP000002659604STRING: ENSP00000265960
    TSC1ENSP000002985524STRING: ENSP00000298552
    TSC2ENSP000002194764STRING: ENSP00000219476
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with STK32B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STK32B (ST32B)

    3 HMDB Compounds for STK32B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section


    REFSEQ mRNAs for STK32B gene (5 alternative transcripts): 
    NM_018401.1  XM_005247982.1  XM_005247983.2  XM_006713893.1  XM_006713894.1  

    Unigene Cluster for STK32B:

    Serine/threonine kinase 32B
    Hs.133062  [show with all ESTs]
    Unigene Representative Sequence: AY358353
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282908(uc003gih.1 uc010ida.1) ENST00000512018 ENST00000512636
    ENST00000510398 ENST00000513705 ENST00000505508 ENST00000511959 ENST00000508728

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STK32B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK32B (see all 10):
    hsa-miR-3671 hsa-miR-3184 hsa-miR-27a hsa-miR-4267 hsa-miR-423-5p hsa-miR-512-5p hsa-miR-544 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidSTK32B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STK32B
    Predesigned siRNA for gene silencing in human, mouse, rat STK32B
    Clone
    Products:
         
    OriGene clones in human, mouse for STK32B (see all 10)
    OriGene ORF clones in mouse, rat for STK32B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STK32B (NM_018401)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK32B
    Addgene plasmids for STK32B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STK32B
    OriGene qSTAR qPCR primer pairs in human, mouse for STK32B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STK32B
      QuantiTect SYBR Green Assays in human, mouse, rat STK32B
      QuantiFast Probe-based Assays in human, mouse, rat STK32B

    Additional mRNA sequence: 

    AJ250839.1 AK055597.1 AK292696.1 AK302915.1 AK313846.1 AL832436.1 AY358353.1 BC020281.1 
    BC024977.1 BC038238.1 BC069203.1 

    6 DOTS entries:

    DT.40114006  DT.95181775  DT.99965328  DT.121242090  DT.300030  DT.99938234 

    11 AceView cDNA sequences:

    BQ068792 AA960957 BM908009 BX100338 BM152207 AI001155 BC069203 AJ250839 
    AY358353 NM_018401 BC038238 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for STK32B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:              -                                         -     -           -                                       
    SP2:              -           -                             -     -           -                                       
    SP3:                          -                             -     -           -                                       
    SP4:                                                                                                                  


    ECgene alternative splicing isoforms for STK32B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STK32B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAACCTTT
    STK32B Expression
    About this image


    STK32B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
    STK32B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STK32B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.133062
        Custom PCR Arrays for STK32B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for STK32B
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    QuantiFast Probe-based Assays in human, mouse, rat STK32B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK32B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section


    This gene was present in the common ancestor of animals.

    Orthologs for STK32B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk32b1 , 5 serine/threonine kinase 32B1, 5 86.88(n)1
    92.03(a)1
      5 (20.18 cM)5
    642931  NM_022416.21  NP_071861.11 
     374468285 
    chicken
    (Gallus gallus)
    Aves STK32B1 serine/threonine kinase 32B 79.23(n)
    88.16(a)
      422850  XM_420796.3  XP_420796.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia stk32b1 serine/threonine kinase 32B 75.33(n)
    82.84(a)
      100495481  XM_002939053.2  XP_002939099.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003308171 serine/threonine-protein kinase 32B-like 67(n)
    67.09(a)
      100330817  XM_002666081.3  XP_002666127.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG329441 CG32944 58.93(n)
    56.08(a)
      40560  NM_001043201.4  NP_001036666.2 
    worm
    (Caenorhabditis elegans)
    Secernentea M03C11.11 M03C11.1 53.84(n)
    47.23(a)
      176456  NM_066893.3  NP_499294.1 


    ENSEMBL Gene Tree for STK32B (if available)
    TreeFam Gene Tree for STK32B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for STK32B gene
    STK32C2  SGK4942  STK32A2  
    Selected SIMAP similar genes for STK32B using alignment to 3 protein entries:     ST32B_HUMAN (see all proteins) (see all similar genes):
    DKFZp762M113    STK32A    STK32C    SGK2    PRKACB    KIN27
    RPS6KA6    CHEK2    DKFZp564L2416    DKFZp781N0293    PRKACA    STK36
    ADRBK1    AKT1    AKT3    PRKAA1    PRKACG    PRKCH

    Find genes that share paralogs with STK32B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section


    Selected SNPs for STK32B (see all 12622)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0411664
    A metastatic melanoma sample4--see VAR_0411662 G E mis40--------
    rs1380141881,2
    --5051581(+) AGTGCG/TGGGAT 1 -- us2k10--------
    rs1411232281,2
    C--5051603(+) GCCCCA/CACGCC 1 -- us2k10--------
    rs284584571,2
    C,F--5051606(+) CCCACG/TCCCGG 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs1848285451,2
    --5051882(+) GTGTAC/TGCTTG 1 -- us2k10--------
    rs1886630641,2
    --5051931(+) TATTAC/TATGCC 1 -- us2k10--------
    rs622916161,2
    C,F--5052063(+) AATGGT/CAGAGC 1 -- us2k12Minor allele frequency- C:0.18NA 122
    rs1412970891,2
    C--5052137(+) AGAGA-/TTTTTT 1 -- us2k10--------
    rs1382372051,2
    --5052173(+) TGTATG/TAGTCT 1 -- us2k10--------
    rs1418587481,2
    --5052224(+) GGGGAC/GAGAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for STK32B (5053169 - 5303169 bp, first 250kb of STK32B)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STK32B (see all 31):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1526304CNV Deletion17803354
    esv2678136CNV Deletion23128226
    esv2726974CNV Deletion23290073
    esv2726971CNV Deletion23290073
    esv2657644CNV Deletion23128226
    esv1007800CNV Deletion20482838
    esv2663309CNV Deletion23128226
    esv1790419CNV Deletion17803354
    esv2726972CNV Deletion23290073
    esv2726975CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STK32B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    1 disease for STK32B:    
    About MalaCards
    ellis-van creveld syndrome

    1 inferred disease relationship from the University of Copenhagen DISEASES database for STK32B:
    Ellis-Van Creveld syndrome

    Find genes that share disorders with STK32B           About GenesLikeMe

    Genetic Association Database (GAD): STK32B
    Human Genome Epidemiology (HuGE) Navigator: STK32B (4 documents)

    Export disorders for STK32B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section


    PubMed articles for STK32B gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with STK32B)

    1. Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis. (PubMed id 10700184)1, 2, 3 Ruiz-Perez V.L....Goodship J. (Nat. Genet. 2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Association between genes on chromosome 4p16 and non-syndromic oral clefts in four populations. (PubMed id 20087401)1, 4 Ingersoll R.G....Beaty T.H. (Eur. J. Hum. Genet. 2010)
    4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    5. Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. (PubMed id 19389651)1, 4 Smith J.G....Newton-Cheh C. (Heart Rhythm 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. The protein kinase complement of the human genome. (PubMed id 12471243)1, 2 Manning G.... Sudarsanam S. (Science 2002)
    9. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PubMed id 23535033)1 Sherva R....Green R.C. (amp 2014)
    10. Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy. (PubMed id 23834954)1 Kobayashi D....Fukuda K. (Mol Pain 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55351 HGNC: 14217 AceView: STK32B Ensembl:ENSG00000152953 euGenes: HUgn55351
    ECgene: STK32B H-InvDB: STK32B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STK32B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STK32B gene:
    Search GeneIP for patents involving STK32B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Clones from OriGene, GenScript, Sino Biological, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    CRISPR knockouts from OriGene)
    About This Section


     
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