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Aliases for STK32B Gene

Aliases for STK32B Gene

  • Serine/Threonine Kinase 32B 2 3 5
  • Yet Another Novel Kinase 2 3 4
  • EC 2.7.11.1 4 63
  • YANK2 3 4
  • Gene For Serine/Threonine Protein Kinase 3
  • HSA250839 3
  • EC 2.7.11 63
  • STK32 3
  • STKG6 3

External Ids for STK32B Gene

Previous GeneCards Identifiers for STK32B Gene

  • GC04P005120
  • GC04P005171
  • GC04P004990

Summaries for STK32B Gene

GeneCards Summary for STK32B Gene

STK32B (Serine/Threonine Kinase 32B) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK32C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK32B Gene

Genomics for STK32B Gene

Regulatory Elements for STK32B Gene

Promoters for STK32B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STK32B on UCSC Golden Path with GeneCards custom track

Genomic Location for STK32B Gene

Chromosome:
4
Start:
5,051,211 bp from pter
End:
5,500,998 bp from pter
Size:
449,788 bases
Orientation:
Plus strand

Genomic View for STK32B Gene

Genes around STK32B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK32B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK32B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK32B Gene

Proteins for STK32B Gene

  • Protein details for STK32B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY57-ST32B_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 32B
    Protein Accession:
    Q9NY57
    Secondary Accessions:
    • Q6UXH3
    • Q8IY14

    Protein attributes for STK32B Gene

    Size:
    414 amino acids
    Molecular mass:
    47883 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88719.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STK32B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK32B Gene

Proteomics data for STK32B Gene at MOPED

Post-translational modifications for STK32B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STK32B Gene

Domains & Families for STK32B Gene

Gene Families for STK32B Gene

Suggested Antigen Peptide Sequences for STK32B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NY57

UniProtKB/Swiss-Prot:

ST32B_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK32B: view

Function for STK32B Gene

Molecular function for STK32B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for STK32B Gene

Gene Ontology (GO) - Molecular Function for STK32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with STK32B: view
genes like me logo Genes that share phenotypes with STK32B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STK32B

CRISPR Products

miRNA for STK32B Gene

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK32B Gene

Localization for STK32B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK32B Gene COMPARTMENTS Subcellular localization image for STK32B gene
Compartment Confidence
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for STK32B Gene

Pathways & Interactions for STK32B Gene

SuperPathways for STK32B Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK32B: view

Pathways by source for STK32B Gene

1 Qiagen pathway for STK32B Gene

Interacting Proteins for STK32B Gene

Gene Ontology (GO) - Biological Process for STK32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with STK32B: view

No data available for SIGNOR curated interactions for STK32B Gene

Drugs & Compounds for STK32B Gene

(2) Drugs for STK32B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for STK32B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK32B: view

Transcripts for STK32B Gene

mRNA/cDNA for STK32B Gene

Unigene Clusters for STK32B Gene

Serine/threonine kinase 32B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK32B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4:

Relevant External Links for STK32B Gene

GeneLoc Exon Structure for
STK32B
ECgene alternative splicing isoforms for
STK32B

Expression for STK32B Gene

mRNA expression in normal human tissues for STK32B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for STK32B Gene Hs.133062

genes like me logo Genes that share expression patterns with STK32B: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for STK32B Gene

Orthologs for STK32B Gene

This gene was present in the common ancestor of animals.

Orthologs for STK32B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STK32B 35
  • 90.7 (n)
  • 95.12 (a)
STK32B 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK32B 35
  • 89.69 (n)
  • 92.75 (a)
STK32B 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk32b 35
  • 86.88 (n)
  • 92.03 (a)
Stk32b 16
Stk32b 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STK32B 35
  • 94.39 (n)
  • 92.44 (a)
STK32B 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk32b 35
  • 86.47 (n)
  • 90.58 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia STK32B 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK32B 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK32B 35
  • 79.23 (n)
  • 88.16 (a)
STK32B 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk32b 35
  • 75.33 (n)
  • 82.84 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100330817 35
  • 67 (n)
  • 67.09 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000477 35
  • 59.29 (n)
  • 54.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32944 35
  • 58.93 (n)
  • 56.08 (a)
CG32944 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M03C11.1 35
  • 53.84 (n)
  • 47.23 (a)
M03C11.1 36
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for STK32B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK32B Gene

ENSEMBL:
Gene Tree for STK32B (if available)
TreeFam:
Gene Tree for STK32B (if available)

Paralogs for STK32B Gene

Paralogs for STK32B Gene

genes like me logo Genes that share paralogs with STK32B: view

Variants for STK32B Gene

Sequence variations from dbSNP and Humsavar for STK32B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs3733182 - 5,446,702(-) GCCTC(C/T)GTCCA reference, missense
VAR_041166 A metastatic melanoma sample
rs35207488 - 5,456,871(+) GGAGC(A/G)TGTCC reference, missense, utr-variant-3-prime
rs56259884 - 5,466,722(+) CTGCG(A/G/T)TCCCA reference, missense
rs55961955 - 5,466,818(+) CACAA(A/C)GGACA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for STK32B Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
esv1526304 CNV Deletion 17803354
nsv521349 CNV Loss 19592680
esv9538 OTHER Inversion 19470904
nsv878513 CNV Gain 21882294
nsv878514 CNV Loss 21882294
esv2726971 CNV Deletion 23290073
nsv527143 CNV Loss 19592680
esv2726972 CNV Deletion 23290073
nsv471805 CNV Loss 16327809
esv1007800 CNV Deletion 20482838
dgv134n6 CNV Loss 16902084
esv2726974 CNV Deletion 23290073
esv2752049 CNV Loss 17911159
esv2726975 CNV Deletion 23290073
nsv878515 CNV Gain 21882294
esv2668377 CNV Deletion 23128226
esv3269 OTHER Inversion 18987735
esv2678136 CNV Deletion 23128226
esv1790419 CNV Deletion 17803354
esv2657644 CNV Deletion 23128226
esv23244 CNV Loss 19812545
dgv639n27 CNV Loss 19166990
nsv878516 CNV Gain 21882294
nsv527989 CNV Gain 19592680
esv2663309 CNV Deletion 23128226
nsv878517 CNV Gain 21882294
nsv878518 CNV Gain 21882294
nsv878519 CNV Loss 21882294
nsv520417 CNV Loss 19592680
nsv461181 CNV Loss 19166990

Variation tolerance for STK32B Gene

Residual Variation Intolerance Score: 11.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.46; 88.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK32B Gene

HapMap Linkage Disequilibrium report
STK32B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK32B Gene

Disorders for STK32B Gene

Relevant External Links for STK32B

Genetic Association Database (GAD)
STK32B
Human Genome Epidemiology (HuGE) Navigator
STK32B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK32B

No disorders were found for STK32B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK32B Gene

Publications for STK32B Gene

  1. Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis. (PMID: 10700184) Ruiz-Perez V.L. … Goodship J. (Nat. Genet. 2000) 2 3 4 67
  2. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PMID: 23535033) Sherva R. … Green R.C. (Alzheimers Dement 2014) 3
  3. Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy. (PMID: 23834954) Kobayashi D. … Fukuda K. (Mol Pain 2013) 3
  4. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PMID: 23936387) A9stensson M. … Torinsson-Naluai A.8. (PLoS ONE 2013) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for STK32B Gene

Sources for STK32B Gene

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