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Aliases for STK32A Gene

Aliases for STK32A Gene

  • Serine/Threonine Kinase 32A 2 3 5
  • Yet Another Novel Kinase 1 3 4
  • EC 2.7.11.1 4 61
  • YANK1 3 4
  • Serine/Threonine-Protein Kinase 32A 3
  • A930015B13Rik 3
  • CTB-108O6.2 3
  • EC 2.7.11 61

External Ids for STK32A Gene

Previous GeneCards Identifiers for STK32A Gene

  • GC05P146645
  • GC05P146594
  • GC05P141761

Summaries for STK32A Gene

GeneCards Summary for STK32A Gene

STK32A (Serine/Threonine Kinase 32A) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK32B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK32A Gene

Genomics for STK32A Gene

Regulatory Elements for STK32A Gene

Enhancers for STK32A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around STK32A on UCSC Golden Path with GeneCards custom track

Promoters for STK32A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STK32A on UCSC Golden Path with GeneCards custom track

Genomic Location for STK32A Gene

Chromosome:
5
Start:
147,234,963 bp from pter
End:
147,401,533 bp from pter
Size:
166,571 bases
Orientation:
Plus strand

Genomic View for STK32A Gene

Genes around STK32A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK32A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK32A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK32A Gene

Proteins for STK32A Gene

  • Protein details for STK32A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU08-ST32A_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 32A
    Protein Accession:
    Q8WU08
    Secondary Accessions:
    • B3KSY0

    Protein attributes for STK32A Gene

    Size:
    396 amino acids
    Molecular mass:
    46369 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for STK32A Gene

    Alternative splice isoforms for STK32A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK32A Gene

Selected DME Specific Peptides for STK32A Gene

Post-translational modifications for STK32A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STK32A Gene

Domains & Families for STK32A Gene

Gene Families for STK32A Gene

Protein Domains for STK32A Gene

Suggested Antigen Peptide Sequences for STK32A Gene

Graphical View of Domain Structure for InterPro Entry

Q8WU08

UniProtKB/Swiss-Prot:

ST32A_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK32A: view

Function for STK32A Gene

Molecular function for STK32A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for STK32A Gene

Gene Ontology (GO) - Molecular Function for STK32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with STK32A: view
genes like me logo Genes that share phenotypes with STK32A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STK32A

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK32A Gene

Localization for STK32A Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK32A Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK32A Gene COMPARTMENTS Subcellular localization image for STK32A gene
Compartment Confidence
cytosol 3
plasma membrane 3
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for STK32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with STK32A: view

Pathways & Interactions for STK32A Gene

SuperPathways for STK32A Gene

No Data Available

Interacting Proteins for STK32A Gene

Gene Ontology (GO) - Biological Process for STK32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018105 peptidyl-serine phosphorylation IBA --
GO:0035556 intracellular signal transduction IBA --
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
genes like me logo Genes that share ontologies with STK32A: view

No data available for Pathways by source and SIGNOR curated interactions for STK32A Gene

Drugs & Compounds for STK32A Gene

(2) Drugs for STK32A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for STK32A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK32A: view

Transcripts for STK32A Gene

Unigene Clusters for STK32A Gene

Serine/threonine kinase 32A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK32A Gene

No ASD Table

Relevant External Links for STK32A Gene

GeneLoc Exon Structure for
STK32A
ECgene alternative splicing isoforms for
STK32A

Expression for STK32A Gene

mRNA expression in normal human tissues for STK32A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK32A Gene

This gene is overexpressed in Brain - Hypothalamus (x5.7).

Protein differential expression in normal tissues from HIPED for STK32A Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STK32A Gene



Protein tissue co-expression partners for STK32A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STK32A Gene:

STK32A

SOURCE GeneReport for Unigene cluster for STK32A Gene:

Hs.585069
genes like me logo Genes that share expression patterns with STK32A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for STK32A Gene

Orthologs for STK32A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STK32A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STK32A 34
  • 90.89 (n)
  • 91.8 (a)
STK32A 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK32A 34
  • 87.56 (n)
  • 88.32 (a)
STK32A 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk32a 34
  • 88.22 (n)
  • 90.66 (a)
Stk32a 16
Stk32a 35
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STK32A 34
  • 99.33 (n)
  • 99.49 (a)
STK32A 35
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk32a 34
  • 88.38 (n)
  • 90.4 (a)
oppossum
(Monodelphis domestica)
Mammalia STK32A 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK32A 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK32A 34
  • 76.46 (n)
  • 77.47 (a)
STK32A 35
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK32A 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk32a 34
  • 72.32 (n)
  • 75.44 (a)
zebrafish
(Danio rerio)
Actinopterygii stk32a 35
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32944 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M03C11.1 35
  • 42 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07062 34
  • 50.62 (n)
  • 43.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppk33 34
  • 48.55 (n)
  • 37.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for STK32A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK32A Gene

ENSEMBL:
Gene Tree for STK32A (if available)
TreeFam:
Gene Tree for STK32A (if available)

Paralogs for STK32A Gene

genes like me logo Genes that share paralogs with STK32A: view

Variants for STK32A Gene

Sequence variations from dbSNP and Humsavar for STK32A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs35852718 - 147,279,311(+) ACAAA(A/T)GTGCG reference, missense
VAR_041164 A metastatic melanoma sample
VAR_041165 A lung neuroendocrine carcinoma sample
rs1424291 -- 147,345,792(-) AGACA(A/C)CAGGT intron-variant
rs1424292 -- 147,317,896(+) TTTTT(A/G)TTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK32A Gene

Variant ID Type Subtype PubMed ID
dgv975n67 CNV gain 20364138
esv1301490 CNV deletion 17803354
esv2669201 CNV deletion 23128226
esv2670464 CNV deletion 23128226
esv2670979 CNV deletion 23128226
esv2730887 CNV deletion 23290073
esv2730888 CNV deletion 23290073
esv2730889 CNV deletion 23290073
esv2763507 CNV loss 21179565
esv3566783 CNV deletion 23714750
esv3607090 CNV loss 21293372
esv3607092 CNV loss 21293372
nsv1114741 CNV deletion 24896259
nsv476569 CNV novel sequence insertion 20440878
nsv519847 CNV gain+loss 19592680
nsv599938 CNV gain 21841781
nsv819857 CNV gain 19587683
nsv820475 CNV deletion 20802225

Variation tolerance for STK32A Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK32A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK32A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK32A Gene

Disorders for STK32A Gene

Relevant External Links for STK32A

Genetic Association Database (GAD)
STK32A
Human Genome Epidemiology (HuGE) Navigator
STK32A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK32A

No disorders were found for STK32A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK32A Gene

Publications for STK32A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. (PMID: 19845895) Koskinen L.L. … Saavalainen P. (Tissue Antigens 2009) 3 46 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for STK32A Gene

Sources for STK32A Gene

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