STK32A Gene
protein-coding GIFtS: 45
GCID: GC05P146594
|
|
serine/threonine kinase 32A
| |
Aliases
for STK32A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine/Threonine Kinase 32A1 2 | | MGC226881 | | YANK11 2 3 | | A930015B13Rik2 | | Yet Another Novel Kinase 12 3 | | Serine/Threonine-Protein Kinase 32A2 | | EC 2.7.11.13 8 | | EC 2.7.118 |
Export aliases for STK32A gene to outside databasesPrevious GC identifers: GC05P146645 GC05P141761 |
Summaries
for STK32A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for STK32A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STK32A gene promoter:
MyoD Nkx2-5 MEF-2A CREB S8 deltaCREB Sox9 c-Myb IRF-7A aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for STK32A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK32A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q32 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q32STK32A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P146594: view genomic region
(about GC identifiers)
Start:
|
146,614,526 bp from pter |
End:
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146,767,415 bp from pter |
Size:
|
152,890 bases |
Orientation:
|
plus strand |
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Proteins
for STK32A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ST32A_HUMAN, Q8WU08 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase 32A Size: 396 amino acids; 46369 Da
Cofactor: Magnesium (By similarity)
1 PDB 3D structure from  and Proteopedia  for STK32A:4FR4 (3D)
Secondary accessions: B3KSY0Alternative splicing: 3 isoforms: Q8WU08-1 Q8WU08-2 Q8WU08-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for STK32A: NX_Q8WU08
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WU08
4/6 DME Specific Peptides for STK32A (Q8WU08) (see all 6)
STK32A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001106195.1 NP_659438.1
ENSEMBL proteins: ENSP00000381030 ENSP00000381535 ENSP00000443156 ENSP00000381533
Human Recombinant Protein Products:
STK32A Antibody Products:
Assay Products for STK32A: |
Protein
Domains /
Families
for STK32A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STK32A for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WU08ProtoNet protein and cluster: Q8WU08 UniProtKB/Swiss-Prot: ST32A_HUMAN, Q8WU08Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for STK32A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ST32A_HUMAN, Q8WU08Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK32A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK32A (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for STK32A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK32A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK32A |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004674 | protein serine/threonine kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
STK32A for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for STK32A:
Animal Models:
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Stk32a):
STK32A for phenotypes About GeneDecksing
|
Pathways & Interactions
for STK32A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STK32A
|
Drugs & Compounds
for STK32A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STK32A
3 HMDB Compounds for STK32A About this table
Search CenterWatch for drugs/clinical trials and news about STK32A / ST32A
|
Transcripts
for STK32A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STK32A gene (2 alternative transcripts): NM_001112724.1 NM_145001.3 Unigene Cluster for STK32A: Serine/threonine kinase 32A Hs.585069 [show with all ESTs]Unigene Representative Sequence: AK09458010 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000306304(uc003lom.2) ENST00000397936(uc010jgn.1 uc011dbw.1)
ENST00000503975 ENST00000398523 ENST00000503384 ENST00000515832 ENST00000506091
ENST00000510953 ENST00000541094(uc003lol.4) ENST00000398521
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK32A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK32A (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): STK32A (NM_001112724) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STK32A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK32A |
Additional cDNA sequence: AK094580.1 AK299099.1 AK315942.1 BC021666.1 5 DOTS entries: DT.99933299 DT.97783652 DT.97795782 DT.91977857 DT.101961848 24/52 AceView cDNA sequences (see all 52): AL134820 AI783693 AI421772 AI382021 AA418184 BX642765 BU194299 N33752 AK094580 CA429631 BQ717813 AA417933 BQ020506 BF966659 BC021666 CA423752 AI826125 AW903324 AW593465 AA910716 BF061937 NM_145001 CD676958 AW149484
GeneLoc Exon Structure
|
Expression
for STK32A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STK32A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTTTGCAA
About this image
See STK32A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STK32A
SOURCE GeneReport for Unigene cluster: Hs.585069
SABiosciences Custom PCR Arrays for STK32A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STK32A
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK32A |
Orthologs
for STK32A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for STK32A gene from 5/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
STK32A1 |
serine/threonine kinase 32A |
76.46(n)
77.47(a) |
|
416351 NM_001025611.1 NP_001020782.1 |
lizard
(Anolis carolinensis) |
Reptilia |
STK32A6 |
-- |
79(a) |
1 ↔ 1 |
2(137486741-137542953) |
zebrafish
(Danio rerio) |
Actinopterygii |
stk32a6 |
serine/threonine kinase 32A |
63(a) |
1 ↔ 1 |
21(41296975-41369611) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG329446 |
-- |
31(a) |
1 → many |
3R(232949-241835) |
worm
(Caenorhabditis elegans) |
Secernentea |
M03C11.16 |
Protein M03C11.1 |
40(a) |
1 → many |
III(10393296-10395988) |
ENSEMBL Gene Tree for STK32A (if available)
TreeFam Gene Tree for STK32A (if available) |
Paralogs
for STK32A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STK32A gene
- STK32B2 STK32C2
18/73 SIMAP similar genes for STK32A using alignment to 3 protein entries: ST32A_HUMAN (see all proteins)
(see all similar genes):STK32C STK32B KIN27 DKFZp762M113 PRKACB MARK3
NEK5 PDPK1 RPS6KA5 PRKACA MARK2 MAST4
PRKY STK36 STK38L ADRBK1 RPS6KA3 DKFZp564L2416
STK32A for paralogs About GeneDecksing
|
Genomic Variants
for STK32A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STK32A (146614526 - 146767415 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for STK32A
1 CNV: 59242
2 Indels: 81068 93279
Human Gene Mutation Database (HGMD): STK32A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STK32A |
|
Disorders
/ Diseases
for STK32A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 STK32A for disorders About MalaCards
STK32A for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: STK32A (2 documents)
Export disorders for STK32A gene to outside databases
|
Publications
for STK32A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STK32A gene integrated from 9 sources:
(articles sorted by number of sources associating them with STK32A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The protein kinase complement of the human genome. (PubMed id 12471243)1, 2 Manning G.... Sudarsanam S. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Fine mapping of the CELIAC2 locus on chromosome 5q31- q33 in the Finnish and Hungarian populations. (PubMed id 19845895)1 Koskinen L.L....Saavalainen P. (2009)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for STK32A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STK32A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STK32A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STK32A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STK32A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STK32A gene:
Search GeneIP for patents involving STK32A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STK32A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | STK32A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK32A |
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