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Aliases for STK32A Gene

Aliases for STK32A Gene

  • Serine/Threonine Kinase 32A 2 3 5
  • Yet Another Novel Kinase 1 3 4
  • EC 2.7.11.1 4 63
  • YANK1 3 4
  • A930015B13Rik 3
  • EC 2.7.11 63

External Ids for STK32A Gene

Previous GeneCards Identifiers for STK32A Gene

  • GC05P146645
  • GC05P146594
  • GC05P141761

Summaries for STK32A Gene

GeneCards Summary for STK32A Gene

STK32A (Serine/Threonine Kinase 32A) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK32B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK32A Gene

Genomics for STK32A Gene

Regulatory Elements for STK32A Gene

Genomic Location for STK32A Gene

Chromosome:
5
Start:
147,234,963 bp from pter
End:
147,401,533 bp from pter
Size:
166,571 bases
Orientation:
Plus strand

Genomic View for STK32A Gene

Genes around STK32A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK32A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK32A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK32A Gene

Proteins for STK32A Gene

  • Protein details for STK32A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU08-ST32A_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 32A
    Protein Accession:
    Q8WU08
    Secondary Accessions:
    • B3KSY0

    Protein attributes for STK32A Gene

    Size:
    396 amino acids
    Molecular mass:
    46369 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for STK32A Gene

    Alternative splice isoforms for STK32A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK32A Gene

Proteomics data for STK32A Gene at MOPED

Selected DME Specific Peptides for STK32A Gene

Post-translational modifications for STK32A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STK32A Gene

Domains & Families for STK32A Gene

Gene Families for STK32A Gene

Suggested Antigen Peptide Sequences for STK32A Gene

Graphical View of Domain Structure for InterPro Entry

Q8WU08

UniProtKB/Swiss-Prot:

ST32A_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK32A: view

Function for STK32A Gene

Molecular function for STK32A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for STK32A Gene

genes like me logo Genes that share phenotypes with STK32A: view

Animal Models for STK32A Gene

MGI Knock Outs for STK32A:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK32A Gene

Localization for STK32A Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK32A Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK32A Gene COMPARTMENTS Subcellular localization image for STK32A gene
Compartment Confidence
cytosol 3
plasma membrane 3
cytoskeleton 1
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for STK32A Gene

Pathways & Interactions for STK32A Gene

SuperPathways for STK32A Gene

No Data Available

Interacting Proteins for STK32A Gene

Gene Ontology (GO) - Biological Process for STK32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with STK32A: view

No data available for Pathways by source and SIGNOR curated interactions for STK32A Gene

Drugs & Compounds for STK32A Gene

(2) Drugs for STK32A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for STK32A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK32A: view

Transcripts for STK32A Gene

Unigene Clusters for STK32A Gene

Serine/threonine kinase 32A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK32A Gene

No ASD Table

Relevant External Links for STK32A Gene

GeneLoc Exon Structure for
STK32A
ECgene alternative splicing isoforms for
STK32A

Expression for STK32A Gene

mRNA expression in normal human tissues for STK32A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK32A Gene

This gene is overexpressed in Brain - Hypothalamus (x5.7).

Protein differential expression in normal tissues from HIPED for STK32A Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STK32A Gene



SOURCE GeneReport for Unigene cluster for STK32A Gene Hs.585069

genes like me logo Genes that share expression patterns with STK32A: view

Protein tissue co-expression partners for STK32A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for STK32A Gene

Orthologs for STK32A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STK32A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STK32A 35
  • 90.89 (n)
  • 91.8 (a)
STK32A 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK32A 35
  • 87.56 (n)
  • 88.32 (a)
STK32A 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk32a 35
  • 88.22 (n)
  • 90.66 (a)
Stk32a 16
Stk32a 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STK32A 35
  • 99.33 (n)
  • 99.49 (a)
STK32A 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk32a 35
  • 88.38 (n)
  • 90.4 (a)
oppossum
(Monodelphis domestica)
Mammalia STK32A 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK32A 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK32A 35
  • 76.46 (n)
  • 77.47 (a)
STK32A 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK32A 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk32a 35
  • 72.32 (n)
  • 75.44 (a)
zebrafish
(Danio rerio)
Actinopterygii stk32a 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32944 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M03C11.1 36
  • 42 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07062 35
  • 50.62 (n)
  • 43.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppk33 35
  • 48.55 (n)
  • 37.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for STK32A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK32A Gene

ENSEMBL:
Gene Tree for STK32A (if available)
TreeFam:
Gene Tree for STK32A (if available)

Paralogs for STK32A Gene

Paralogs for STK32A Gene

genes like me logo Genes that share paralogs with STK32A: view

Variants for STK32A Gene

Sequence variations from dbSNP and Humsavar for STK32A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs35852718 - 147,279,311(+) ACAAA(A/T)GTGCG reference, missense
VAR_041164 A metastatic melanoma sample
VAR_041165 A lung neuroendocrine carcinoma sample
rs31038 -- 147,237,056(-) ggatt(A/G)caggc intron-variant
rs31039 -- 147,237,842(-) GGAAG(C/T)GTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK32A Gene

Variant ID Type Subtype PubMed ID
nsv519847 CNV Gain+Loss 19592680
nsv883014 CNV Loss 21882294
nsv819857 CNV Gain 19587683
dgv975n67 CNV Gain 20364138
nsv820475 CNV Deletion 20802225
esv2730887 CNV Deletion 23290073
esv2670979 CNV Deletion 23128226
esv269401 CNV Insertion 20981092
esv273376 CNV Insertion 20981092
esv2730888 CNV Deletion 23290073
esv2670464 CNV Deletion 23128226
esv2730889 CNV Deletion 23290073
esv1301490 CNV Deletion 17803354
esv2669201 CNV Deletion 23128226

Variation tolerance for STK32A Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK32A Gene

HapMap Linkage Disequilibrium report
STK32A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK32A Gene

Disorders for STK32A Gene

Relevant External Links for STK32A

Genetic Association Database (GAD)
STK32A
Human Genome Epidemiology (HuGE) Navigator
STK32A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK32A

No disorders were found for STK32A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK32A Gene

Publications for STK32A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3
  4. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. (PMID: 19845895) Koskinen L.L. … Saavalainen P. (Tissue Antigens 2009) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for STK32A Gene

Sources for STK32A Gene

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