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Aliases for STK31 Gene

Aliases for STK31 Gene

  • Serine/Threonine Kinase 31 2 3 5
  • Serine/Threonine-Protein Kinase NYD-SPK 3 4
  • Sugen Kinase 396 3 4
  • SGK396 3 4
  • Testis Tissue Sperm-Binding Protein Li 78m 3
  • Tudor Domain Containing 8 3
  • EC 4
  • TDRD8 3

External Ids for STK31 Gene

Previous GeneCards Identifiers for STK31 Gene

  • GC07P023392
  • GC07P023458
  • GC07P023492
  • GC07P023523
  • GC07P023716
  • GC07P023749
  • GC07P023634

Summaries for STK31 Gene

Entrez Gene Summary for STK31 Gene

  • This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK31 Gene

STK31 (Serine/Threonine Kinase 31) is a Protein Coding gene. Diseases associated with STK31 include dravet syndrome. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include nucleic acid binding and protein kinase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK31 Gene

Genomics for STK31 Gene

Regulatory Elements for STK31 Gene

Genomic Location for STK31 Gene

23,710,167 bp from pter
23,832,513 bp from pter
122,347 bases
Plus strand

Genomic View for STK31 Gene

Genes around STK31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK31 Gene

Proteins for STK31 Gene

  • Protein details for STK31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase 31
    Protein Accession:
    Secondary Accessions:
    • B4DZ06
    • B7WPP5
    • C9J4F9
    • Q6PCD3
    • Q9BXH8

    Protein attributes for STK31 Gene

    1019 amino acids
    Molecular mass:
    115694 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STK31 Gene


neXtProt entry for STK31 Gene

Proteomics data for STK31 Gene at MOPED

Post-translational modifications for STK31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for STK31 Gene

Domains & Families for STK31 Gene

Gene Families for STK31 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  • Contains 1 protein kinase domain.
  • Contains 1 Tudor domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK31: view

Function for STK31 Gene

Molecular function for STK31 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for STK31 Gene

Gene Ontology (GO) - Molecular Function for STK31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with STK31: view
genes like me logo Genes that share phenotypes with STK31: view

Animal Models for STK31 Gene

MGI Knock Outs for STK31:

Animal Model Products

  • Taconic Biosciences Mouse Models for STK31

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for STK31 Gene

Localization for STK31 Gene

Subcellular locations from

Jensen Localization Image for STK31 Gene COMPARTMENTS Subcellular localization image for STK31 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for STK31 Gene

Pathways & Interactions for STK31 Gene

SuperPathways for STK31 Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK31: view

Pathways by source for STK31 Gene

1 Qiagen pathway for STK31 Gene

Interacting Proteins for STK31 Gene

Selected Interacting proteins: Q9BXU1-STK31_HUMAN for STK31 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for STK31 Gene


No data available for SIGNOR curated interactions for STK31 Gene

Drugs & Compounds for STK31 Gene

No Compound Related Data Available

Transcripts for STK31 Gene

Unigene Clusters for STK31 Gene

Serine/threonine kinase 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK31 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - -

ExUns: 24 ^ 25 ^ 26 ^ 27

Relevant External Links for STK31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STK31 Gene

mRNA expression in normal human tissues for STK31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK31 Gene

This gene is overexpressed in Testis (x36.6).

Protein differential expression in normal tissues from HIPED for STK31 Gene

This gene is overexpressed in Testis (37.7) and Ovary (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STK31 Gene

SOURCE GeneReport for Unigene cluster for STK31 Gene Hs.309767

mRNA Expression by UniProt/SwissProt for STK31 Gene

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with STK31: view

Protein tissue co-expression partners for STK31 Gene

Primer Products

In Situ Assay Products

Orthologs for STK31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STK31 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC781749 35
  • 88.51 (n)
  • 83.6 (a)
STK31 36
  • 84 (a)
(Canis familiaris)
Mammalia STK31 35
  • 88.74 (n)
  • 83.2 (a)
STK31 36
  • 83 (a)
(Mus musculus)
Mammalia Stk31 35
  • 84.58 (n)
  • 78.44 (a)
Stk31 16
Stk31 36
  • 78 (a)
(Pan troglodytes)
Mammalia STK31 35
  • 99.57 (n)
  • 99.31 (a)
STK31 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Stk31 35
  • 84.61 (n)
  • 78.74 (a)
(Monodelphis domestica)
Mammalia STK31 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia STK31 36
  • 60 (a)
(Gallus gallus)
Aves STK31 35
  • 63.73 (n)
  • 56.08 (a)
STK31 36
  • 53 (a)
(Anolis carolinensis)
Reptilia STK31 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stk31 35
  • 58.03 (n)
  • 48.85 (a)
(Danio rerio)
Actinopterygii LOC100330765 35
  • 50.5 (n)
  • 36.89 (a)
STK31 36
  • 34 (a)
Species with no ortholog for STK31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STK31 Gene

Gene Tree for STK31 (if available)
Gene Tree for STK31 (if available)

Paralogs for STK31 Gene

No data available for Paralogs for STK31 Gene

Variants for STK31 Gene

Sequence variations from dbSNP and Humsavar for STK31 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6945306 - 23,717,543(+) CCCCA(C/G/T)GCCAG nc-transcript-variant, reference, missense
rs10264952 - 23,735,835(+) TAAGT(A/G)AGAAA intron-variant, nc-transcript-variant, reference, missense
rs10264967 - 23,735,858(+) TTGAA(G/T)GATGA intron-variant, nc-transcript-variant, reference, missense
rs35545265 - 23,752,783(+) TAGAT(A/C/T)CCAGA nc-transcript-variant, reference, missense
rs4722266 - 23,754,410(+) GAATG(A/G)ATTAG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for STK31 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
esv2673027 CNV Deletion 23128226
dgv2071e1 CNV Complex 17122850
nsv830924 CNV Loss 17160897
nsv365951 CNV Loss 16902084
nsv510074 CNV Loss 20534489
esv7170 OTHER Inversion 19470904
esv2602899 CNV Deletion 19546169
esv2372085 CNV Deletion 18987734
esv2734131 CNV Deletion 23290073
esv1343786 CNV Deletion 17803354
nsv366286 CNV Loss 16902084
esv2734132 CNV Deletion 23290073

Variation tolerance for STK31 Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.99; 93.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK31 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK31 Gene

Disorders for STK31 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STK31 Gene - From: GeneCards

Disorder Aliases PubMed IDs
dravet syndrome
  • dravet syndrome, modifier of
- elite association - COSMIC cancer census association via MalaCards
Search STK31 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STK31

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with STK31: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK31 Gene

Publications for STK31 Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang P.J. … Page D.C. (Nat. Genet. 2001) 2 3 4 67
  2. GABRA1 and STXBP1: novel genetic causes of Dravet syndrome. (PMID: 24623842) Carvill G.L. … Mefford H.C. (Neurology 2014) 3
  3. STK31 is a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. (PMID: 24667656) Kuo P.L. … Hung L.Y. (PLoS ONE 2014) 3
  4. STK31 maintains the undifferentiated state of colon cancer cells. (PMID: 22828137) Fok K.L. … Chang Chan H. (Carcinogenesis 2012) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for STK31 Gene

Sources for STK31 Gene

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