Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STK31 Gene

Aliases for STK31 Gene

  • Serine/Threonine Kinase 31 2 3 5
  • Serine/Threonine-Protein Kinase NYD-SPK 3 4
  • Sugen Kinase 396 3 4
  • SGK396 3 4
  • Testis Tissue Sperm-Binding Protein Li 78m 3
  • Serine/Threonine-Protein Kinase 31 3
  • Tudor Domain Containing 8 3
  • EC 2.7.11.1 4
  • TDRD8 3

External Ids for STK31 Gene

Previous GeneCards Identifiers for STK31 Gene

  • GC07P023392
  • GC07P023458
  • GC07P023492
  • GC07P023523
  • GC07P023716
  • GC07P023749
  • GC07P023634

Summaries for STK31 Gene

Entrez Gene Summary for STK31 Gene

  • This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK31 Gene

STK31 (Serine/Threonine Kinase 31) is a Protein Coding gene. Diseases associated with STK31 include Dravet Syndrome. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include nucleic acid binding and protein kinase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK31 Gene

Genomics for STK31 Gene

Regulatory Elements for STK31 Gene

Enhancers for STK31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F023722 0.6 ENCODE 42 +12.8 12815 0.4 LEF1 L3MBTL2 NFRKB NR4A1 MAFG ZNF316 JUND FOXK2 SMARCA4 POLR2A STK31 PCMTD1P3 TPT1P7
GH07F023759 1 Ensembl ENCODE 22.6 +50.1 50055 1.3 HDAC1 PKNOX1 FEZF1 BRCA1 RFX5 YY1 ZNF366 SCRT2 RCOR1 CEBPB STK31 FAM221A PCMTD1P3 TPT1P7
GH07F023713 0.2 ENCODE 16.9 +3.8 3790 1.4 ZNF316 JUND BHLHE40 MAFG FOS EMSY SPI1 STK31 FAM221A PCMTD1P3
GH07F023697 0.2 ENCODE 12.9 -13.0 -12991 0.3 CTCF TAL1 MAX ZIC2 ZNF644 RAD21 CHAMP1 ZFHX2 EGR1 POLR2A TRA2A STK31 ENSG00000234286
GH07F023462 1 FANTOM5 ENCODE 11.3 -240.8 -240798 13.3 CREB3L1 MLX FEZF1 DMAP1 ZNF263 SP3 NFYC TBX21 MEF2D SSRP1 ENSG00000227930 EEF1A1P6 STK31 TRA2A IGF2BP3 CCDC126 KLHL7-AS1 NUPL2 MALSU1 GC07P023450
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around STK31 on UCSC Golden Path with GeneCards custom track

Genomic Location for STK31 Gene

Chromosome:
7
Start:
23,710,167 bp from pter
End:
23,832,513 bp from pter
Size:
122,347 bases
Orientation:
Plus strand

Genomic View for STK31 Gene

Genes around STK31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK31 Gene

Proteins for STK31 Gene

  • Protein details for STK31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXU1-STK31_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 31
    Protein Accession:
    Q9BXU1
    Secondary Accessions:
    • B4DZ06
    • B7WPP5
    • C9J4F9
    • Q6PCD3
    • Q9BXH8

    Protein attributes for STK31 Gene

    Size:
    1019 amino acids
    Molecular mass:
    115694 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STK31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK31 Gene

Post-translational modifications for STK31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STK31 Gene

Domains & Families for STK31 Gene

Gene Families for STK31 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXU1

UniProtKB/Swiss-Prot:

STK31_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 Tudor domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK31: view

Function for STK31 Gene

Molecular function for STK31 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for STK31 Gene

Gene Ontology (GO) - Molecular Function for STK31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004518 nuclease activity IBA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with STK31: view
genes like me logo Genes that share phenotypes with STK31: view

Animal Models for STK31 Gene

MGI Knock Outs for STK31:

Animal Model Products

  • Taconic Biosciences Mouse Models for STK31

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for STK31 Gene

Localization for STK31 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK31 Gene COMPARTMENTS Subcellular localization image for STK31 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for STK31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with STK31: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for STK31 Gene

Pathways & Interactions for STK31 Gene

SuperPathways for STK31 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK31: view

Pathways by source for STK31 Gene

1 Qiagen pathway for STK31 Gene

Interacting Proteins for STK31 Gene

Gene Ontology (GO) - Biological Process for STK31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006401 RNA catabolic process IBA --
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with STK31: view

No data available for SIGNOR curated interactions for STK31 Gene

Transcripts for STK31 Gene

Unigene Clusters for STK31 Gene

Serine/threonine kinase 31:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK31 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - -
SP2:
SP3:
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26 ^ 27
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for STK31 Gene

GeneLoc Exon Structure for
STK31
ECgene alternative splicing isoforms for
STK31

Expression for STK31 Gene

mRNA expression in normal human tissues for STK31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK31 Gene

This gene is overexpressed in Testis (x36.6).

Protein differential expression in normal tissues from HIPED for STK31 Gene

This gene is overexpressed in Testis (37.7) and Ovary (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STK31 Gene



Protein tissue co-expression partners for STK31 Gene

NURSA nuclear receptor signaling pathways regulating expression of STK31 Gene:

STK31

SOURCE GeneReport for Unigene cluster for STK31 Gene:

Hs.309767

mRNA Expression by UniProt/SwissProt for STK31 Gene:

Q9BXU1-STK31_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with STK31: view

Primer Products

Orthologs for STK31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STK31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK31 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia STK31 34 35
  • 88.74 (n)
cow
(Bos Taurus)
Mammalia LOC781749 34
  • 88.51 (n)
STK31 35
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk31 34
  • 84.61 (n)
mouse
(Mus musculus)
Mammalia Stk31 34 16 35
  • 84.58 (n)
oppossum
(Monodelphis domestica)
Mammalia STK31 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK31 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK31 34 35
  • 63.73 (n)
lizard
(Anolis carolinensis)
Reptilia STK31 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk31 34
  • 58.03 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330765 34
  • 50.5 (n)
STK31 35
  • 34 (a)
OneToOne
Species where no ortholog for STK31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STK31 Gene

ENSEMBL:
Gene Tree for STK31 (if available)
TreeFam:
Gene Tree for STK31 (if available)

Paralogs for STK31 Gene

No data available for Paralogs for STK31 Gene

Variants for STK31 Gene

Sequence variations from dbSNP and Humsavar for STK31 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_041158 A lung neuroendocrine carcinoma sample
VAR_041160 A lung small cell carcinoma sample
rs1017192 -- 23,770,067(+) GAATG(C/T)GTCAT intron-variant
rs10215061 -- 23,822,529(+) ttttg(A/G)tggag intron-variant
rs10215107 -- 23,798,154(+) acagt(C/T)gaatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK31 Gene

Variant ID Type Subtype PubMed ID
esv1343786 CNV deletion 17803354
esv2372085 CNV deletion 18987734
esv2602899 CNV deletion 19546169
esv2673027 CNV deletion 23128226
esv2734131 CNV deletion 23290073
esv2734132 CNV deletion 23290073
esv2759519 CNV loss 17122850
esv7170 OTHER inversion 19470904
nsv1068712 OTHER inversion 25765185
nsv1109853 CNV deletion 24896259
nsv1129435 OTHER inversion 24896259
nsv1142665 CNV deletion 24896259
nsv1151728 CNV deletion 26484159
nsv365951 CNV deletion 16902084
nsv366286 CNV deletion 16902084
nsv510074 OTHER sequence alteration 20534489
nsv7393 OTHER inversion 18451855
nsv830924 CNV loss 17160897
nsv970451 CNV duplication 23825009

Variation tolerance for STK31 Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.99; 93.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK31 Gene

Disorders for STK31 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STK31 Gene - From: GeneCards

Disorder Aliases PubMed IDs
dravet syndrome
  • dravet syndrome, modifier of
- elite association - COSMIC cancer census association via MalaCards
Search STK31 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STK31

Genetic Association Database (GAD)
STK31
Human Genome Epidemiology (HuGE) Navigator
STK31
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK31
genes like me logo Genes that share disorders with STK31: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK31 Gene

Publications for STK31 Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang P.J. … Page D.C. (Nat. Genet. 2001) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  5. Serine/threonine kinases 31(STK31) may be a novel cellular target gene for the HPV16 oncogene E7 with potential as a DNA hypomethylation biomarker in cervical cancer. (PMID: 27044426) Yin F.F. … Wang Y.K. (Virol. J. 2016) 3 64

Products for STK31 Gene

Sources for STK31 Gene

Content
Loading form....