STK3 Gene
protein-coding GIFtS: 67
GCID: GC08M099413
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|
serine/threonine kinase 3(Previous names: serine/threonine kinase 3 (Ste20, yeast homolog) )
| |
Aliases
for STK3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine/Threonine Kinase 31 2 | | MST-22 3 | | KRS11 2 3 | | STE20-Like Kinase MST22 3 | | MST21 2 3 | | EC 2.7.11.13 8 | | Serine/Threonine Kinase 3 (Ste20, Yeast Homolog)1 2 | | Serine/Threonine Kinase 3 (STE20 Homolog, Yeast)2 | | Mammalian STE20-Like Protein Kinase 22 3 | | Serine/Threonine-Protein Kinase 32 | | Serine/Threonine-Protein Kinase Krs-12 3 | | EC 2.7.118 |
Export aliases for STK3 gene to outside databasesPrevious GC identifers: GC08M098475 GC08M099540 GC08M099135 GC08M099423 GC08M099536 GC08M099466 GC08M094670 |
Summaries
for STK3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for STK3:
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded proteinfunctions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminalportion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase whichpromotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms havebeen found for this gene. (provided by RefSeq, Jan 2012)
UniProtKB/Swiss-Prot: STK3_HUMAN, Q13188Function: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induceschromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathwaywhich plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promotingapoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex withits regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, whichin turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits itstranslocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cellmigration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activationof facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (Bysimilarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 tocentrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptionalactivity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppressionof the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38
Gene Wiki entry for STK3
|
Genomic Views
for STK3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STK3 gene promoter:
AhR STAT5B C/EBPbeta FOXF2 MyoD CUTL1 FOXL1 FOXJ2 (long isoform) FOXJ2 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for STK3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q22.2 Ensembl cytogenetic band: 8q22.2 HGNC cytogenetic band: 8q22.2STK3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M099413: view genomic region
(about GC identifiers)
Start:
|
99,413,631 bp from pter |
End:
|
99,955,055 bp from pter |
Size:
|
541,425 bases |
Orientation:
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minus strand |
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Proteins
for STK3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STK3_HUMAN, Q13188 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase 3 Size: 491 amino acids; 56301 Da
Cofactor: Magnesium
Subunit: Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation (Bysimilarity). Interacts with and stabilizes SAV1. Interacts with RAF1, which prevents dimerization and phosphorylation.Interacts with RASSF1. Interacts (via SARAH domain) with isoform 1 of NEK2. Interacts with ESR1 only in the presenceof SAV1. Interacts with PKB/AKT1. Forms a tripartite complex with MOBKL1B and STK38. Interacts with RASSF2 (via SARAHdomain)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=The caspase-cleaved form cycles betweennucleus and cytoplasm (By similarity). Phosphorylation at Thr-117 leads to inhibition of nuclear translocation
Secondary accessions: A8K722 Q15445 Q15801 Q96FM6Explore the universe of human proteins at neXtProt for STK3: NX_Q13188
Post-translational modifications:
Phosphorylation at Thr-117 and Thr-384 by PKB/AKT1, leads to inhibition of its: cleavage, kinase activity,autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation, and increase in its binding to RAF11
Proteolytically cleaved by caspase-3 during apoptosis. Proteolytic cleavage results in kinase activation and nucleartranslocation of the truncated form (MST1/N)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13188
4/24 DME Specific Peptides for STK3 (Q13188) (see all 24)
STK3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001243241.1 NP_001243242.1 NP_006272.2
ENSEMBL proteins: ENSP00000390500 ENSP00000429744 ENSP00000428014 ENSP00000429369 ENSP00000428167 ENSP00000428295 Reactome Protein details: Q13188
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
STK3 for ontologies About GeneDecksing
STK3 Antibody Products:
Assay Products for STK3: |
Protein
Domains /
Families
for STK3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STK3 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q13188ProtoNet protein and cluster: Q13188 UniProtKB/Swiss-Prot: STK3_HUMAN, Q13188Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamilySimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 SARAH domain |
Function
for STK3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STK3_HUMAN, Q13188Function: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induceschromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathwaywhich plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promotingapoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex withits regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, whichin turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits itstranslocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cellmigration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activationof facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (Bysimilarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 tocentrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptionalactivity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppressionof the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Inhibited by the C-terminal non-catalytic region. Activated by caspase-cleavage. Full activationalso requires homodimerization and autophosphorylation of Thr-180, which are inhibited by the proto-oncogene productRAF1. Activated by RASSF1 which acts by preventing its dephosphorylationInduction: Activity increases during mitosis Genatlas biochemistry entry for STK3:serine threonine kinase 3
Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for STK3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK3 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
STK3 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for STK3:
Animal Models:
Mouse knock-outs for STK3: Stk3tm1.1Yy Stk3tm1Dlim Stk3tm1.1Jav
15/17 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Stk3) (see all 17):
STK3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for STK3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | MAPK signaling pathway | | | 2 | Cytoskeletal Signaling | | | 3 | Apoptosis and Autophagy | | | 4 | Signaling by Hippo | | | 5 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for STK3
2 
Cell Signaling Technology (CST) Pathways for STK3
1  BioSystems Pathway for STK3
2 
Reactome Pathways for STK3
1 
Kegg Pathway (Kegg details for STK3):
STK3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STK3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/223 Interacting proteins for STK3 (Q131881, 2, 3 ENSP000003905004) via UniProtKB, MINT, STRING, and/or I2D (see all 223)About this table
Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table
STK3 for ontologies About GeneDecksing
|
Drugs & Compounds
for STK3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
STK3 for compounds About GeneDecksing
 Browse Tocris compounds for STK3
3 HMDB Compounds for STK3 About this table
2 Novoseek chemical compound relationships for STK3 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| threonine |
46.5 |
2 |
8566796 (1), 17379520 (1) |
| serine |
33.1 |
2 |
8566796 (1), 17379520 (1) |
Search CenterWatch for drugs/clinical trials and news about STK3
|
Transcripts
for STK3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STK3 gene (3 alternative transcripts): NM_001256312.1 NM_001256313.1 NM_006281.3 Unigene Cluster for STK3: Serine/threonine kinase 3 Hs.492333 [show with all ESTs]Unigene Representative Sequence: NM_00125631217 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000517832 ENST00000419617(uc003yip.3 uc010mbm.1) ENST00000523601(uc003yio.3)
ENST00000520440 ENST00000518582 ENST00000523159 ENST00000518165 ENST00000518627
ENST00000522924 ENST00000521649 ENST00000520053 ENST00000521768 ENST00000520653
ENST00000424861 ENST00000523567 ENST00000523960 ENST00000519420
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STK3 (NM_006281) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STK3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK3 |
Additional cDNA sequence: AK075229.1 AK131363.1 AK291837.1 AK307787.1 AK312660.1 BC010640.2 U26424.1 U60206.1 Z25422.1 10 DOTS entries: DT.215842 DT.100637314 DT.91721027 DT.121466825 DT.100754405 DT.102833033 DT.121466843 DT.86858028 DT.91875264 DT.92014795 24/141 AceView cDNA sequences (see all 141): AL079539 CA391460 AA370619 R22038 AA464529 AL708786 BQ423964 AL527704 BQ723525 AW300076 AW168289 AA371498 BU689201 AK131363 BF035235 CD742983 AL546605 AA370618 BU186529 CB143850 BU182450 AA954682 BI964879 BP335254
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for STK3 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for STK3
|
Expression
for STK3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STK3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCTGATGA
About this image
See STK3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STK3
SOURCE GeneReport for Unigene cluster: Hs.492333
UniProtKB/Swiss-Prot: STK3_HUMAN, Q13188Tissue specificity: Expressed at high levels in adult kidney, skeletal and placenta tissues and at very low levels inadult heart, lung and brain tissues
SABiosciences Expression via Pathway-Focused PCR Array including STK3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STK3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STK3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STK3 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STK3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK3 |
Orthologs
for STK3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for STK3 gene from 5/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC4253756 |
hypothetical protein LOC425375 |
97(a) |
1 ↔ 1 |
2(132614147-132783669) |
lizard
(Anolis carolinensis) |
Reptilia |
STK36 |
-- |
93(a) |
1 ↔ 1 |
4(20958078-21038103) |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc19e112 |
wufc19e11 |
77.8(n) |
|
324125 BC048033.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG112283
hpo1 |
protein amino acid phosphorylation receptor
signaling more3
hippo1 |
51(a)3
59.32(n)1
63.47(a)1 |
|
56D133
372471 NM_137583.41 NP_611427.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
C24A8.4a3
cst-21 |
G-protein coupled receptor3
Protein CST-21 |
59(a)
(best of 4)3
62.37(n)1
64.43(a)1 |
|
X(4365362-4371318)3
1807071 NM_001047754.21 NP_001041219.21 |
ENSEMBL Gene Tree for STK3 (if available)
TreeFam Gene Tree for STK3 (if available) |
Paralogs
for STK3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STK3 gene
- STK242 STK42 STK252 MST42
18/56 SIMAP similar genes for STK3 using alignment to 5 protein entries: STK3_HUMAN (see all proteins)
(see all similar genes):STK4/SLC36AL fusion STK4 DKFZp686A2068 CDK3 CDKL2 STK25
STK24 CDK1 DKFZp686J1430 MAP4K2 PAK4 TAOK3
MYO3A MST4 MYO3B MAP4K4 MAP4K1 PAK3
STK3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for STK3
PGOHUM00000233139
|
Genomic Variants
for STK3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STK3 (99413631 - 99663631 bp, first 250kb of STK3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for STK3
1 CNV: 100435 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STK3 |
|
Disorders
/ Diseases
for STK3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STK3 for disorders About GeneDecksing
OMIM gene information: 605030
OMIM disorders: --
6  diseases for STK3: About MalaCardssoft tissue sarcoma squamous cell carcinoma conjunctivitis sarcoma
hepatocellular carcinoma carcinoma
2 Novoseek disease relationships for STK3 gene About this table
Export disorders for STK3 gene to outside databases
|
Publications
for STK3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STK3 gene, integrated from 9 sources (see all 68):
(articles sorted by number of sources associating them with STK3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Newly identified stress-responsive protein kinases, Krs-1 and Krs- 2. (PubMed id 8816758)1, 2, 3 Taylor L.K.... Erikson R.L. (1996)
- Mammalian Ste20-like kinase (Mst2) indirectly support s Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalyti c subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation . (PubMed id 20212043)1, 2, 9 Kilili G.K. and Kyriakis J.M. (2010)
- Regulation of proapoptotic mammalian ste20-like kinas e MST2 by the IGF1-Akt pathway. (PubMed id 20231902)1, 2, 9 Kim D....Cheng J.Q. (2010)
- MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. (PubMed id 18328708)1, 2, 9 Praskova M....Avruch J. (2008)
- Role of the kinase MST2 in suppression of apoptosis by the proto- oncogene product Raf-1. (PubMed id 15618521)1, 2, 9 O'Neill E.... Kolch W. (2004)
- Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. (PubMed id 8566796)1, 2, 9 Creasy C.L. and Chernoff J. (1995)
- The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. (PubMed id 15688006)1, 2, 9 Chan E.H.Y.... Sillje H.H.W. (2005)
- MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. (PubMed id 11278283)1, 2, 9 Lee K.-K.... Yonehara S. (2001)
- Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand. (PubMed id 21104395)1, 2 Park Y.... Lee Y. (2011)
- The tumor suppressor RASSF1A prevents dephosphorylati on of the mammalian STE20-like kinases MST1 and MST2. (PubMed id 21199877)1, 2 Guo C....Pfeifer G.P. (2011)
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External Searches for STK3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing STK3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing STK3 gene
(According to HUGE)
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Specialized Databases showing STK3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for STK3 gene:
Search GeneIP for patents involving STK3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for STK3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for STK3 | | OriGene shRNA RFP for STK3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STK3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STK3 | | | OriGene Protein Over-expression Lysate for STK3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STK3 | | OriGene 3'-UTR Clone for STK3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for STK3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for STK3 | | OriGene Custom Protein Services for STK3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STK3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STK3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STK3 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STK3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STK3 |
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| | Antibodies & Assays for STK3 (MST2) |
| | | | Search Tocris compounds for STK3 |
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 | | | STK3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK3 |
|  |  |  | | | | ThermoFisher Antibodies for STK3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK3 |
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