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Aliases for STK26 Gene

Aliases for STK26 Gene

  • Serine/Threonine Kinase 26 2 3 5
  • Serine/Threonine-Protein Kinase MASK 3 4
  • STE20-Like Kinase MST4 3 4
  • STE20-Like Kinase 4 2 3
  • EC 2.7.11.1 4 58
  • MASK 3 4
  • MST4 3 4
  • Mammalian Ste20-Like Protein Kinase 4 3
  • Mammalian STE20-Like Protein Kinase 4 4
  • Serine/Threonine Protein Kinase MST4 3
  • Serine/Threonine Protein Kinase 26 3
  • Serine/Threonine-Protein Kinase 26 3
  • Mst3 And SOK1-Related Kinase 3
  • MST3 And SOK1-Related Kinase 4
  • Mammalian Sterile 20-Like 4 3
  • EC 2.7.11 58
  • MST-4 4

External Ids for STK26 Gene

Summaries for STK26 Gene

Entrez Gene Summary for STK26 Gene

  • The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK26 Gene

STK26 (Serine/Threonine Kinase 26) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Apoptotic cleavage of cellular proteins. GO annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is STK24.

UniProtKB/Swiss-Prot for STK26 Gene

  • Mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006).

Gene Wiki entry for STK26 Gene

Additional gene information for STK26 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK26 Gene

Genomics for STK26 Gene

Regulatory Elements for STK26 Gene

Enhancers for STK26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH132022 1.4 FANTOM5 ENCODE 9.3 +1.1 1083 4.3 ATF1 ARID4B SIN3A BRCA1 GLIS2 RUNX3 SP3 GTF2B REST ZNF610 STK26 RAP2C MBNL3 FRMD7
GH0XH132086 0.4 FANTOM5 10.3 +63.8 63802 0.5 FRMD7 RAP2C STK26
GH0XH132479 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.9 +457.7 457687 2.8 PKNOX1 FOXA2 ARID4B FEZF1 YY1 RUNX3 SP3 JUNB ZNF518A ZNF592 FRMD7 MBNL3 STK26 GC0XM132373
GH0XH132090 0.4 FANTOM5 7.2 +67.5 67473 0.6 RAP2C STK26 FRMD7
GH0XH132088 0.3 FANTOM5 5.9 +65.8 65819 0.3 FRMD7 RAP2C STK26
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STK26 on UCSC Golden Path with GeneCards custom track

Promoters for STK26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248804 483 3001 ATF1 ARID4B SIN3A BRCA1 GLIS2 RUNX3 SP3 GTF2B REST ZNF610

Genomic Locations for STK26 Gene

Genomic Locations for STK26 Gene
chrX:132,023,217-132,075,943
(GRCh38/hg38)
Size:
52,727 bases
Orientation:
Plus strand
chrX:131,157,245-131,209,971
(GRCh37/hg19)

Genomic View for STK26 Gene

Genes around STK26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK26 Gene

Proteins for STK26 Gene

  • Protein details for STK26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P289-STK26_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 26
    Protein Accession:
    Q9P289
    Secondary Accessions:
    • B2RAU2
    • Q3ZB77
    • Q8NC04
    • Q9BXC3
    • Q9BXC4

    Protein attributes for STK26 Gene

    Size:
    416 amino acids
    Molecular mass:
    46529 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer (PubMed:20730082). Interacts with PDCD10 (PubMed:17360971, PubMed:19370760, PubMed:20332113). Interacts with GOLGA2 (PubMed:15037601, PubMed:20332113). Interacts with CTTNBP2NL (PubMed:18782753). Interacts with RIPOR1 (via C-terminus); this interaction occurs in a PDCD10-dependent and Rho-independent manner (PubMed:27807006). Interacts with PDCD10; this interaction is required for the association of STK26 with RIPOR1 (PubMed:27807006).

    Three dimensional structures from OCA and Proteopedia for STK26 Gene

    Alternative splice isoforms for STK26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK26 Gene

Selected DME Specific Peptides for STK26 Gene

Q9P289:
  • IGKGSFGEV
  • GTPFWMAP
  • LLKHKFI
  • KADIWSLGIT
  • LDYLHSE
  • ADFGVAGQLTDT
  • VKLADFG
  • VAIKIID
  • GITAIEL
  • WMAPEVI
  • KLWIIMEYL
  • AEDEIEDIQQEI
  • HRDIKAAN
  • IHRDIKAAN

Post-translational modifications for STK26 Gene

  • Ubiquitination at Lys233
  • Modification sites at PhosphoSitePlus

Domains & Families for STK26 Gene

Gene Families for STK26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for STK26 Gene

Suggested Antigen Peptide Sequences for STK26 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P289

UniProtKB/Swiss-Prot:

STK26_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STK26: view

Function for STK26 Gene

Molecular function for STK26 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage.
UniProtKB/Swiss-Prot Function:
Mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006).

Enzyme Numbers (IUBMB) for STK26 Gene

Gene Ontology (GO) - Molecular Function for STK26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 11641781
GO:0004672 protein kinase activity IMP 22797597
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 15037601
genes like me logo Genes that share ontologies with STK26: view
genes like me logo Genes that share phenotypes with STK26: view

Animal Model Products

CRISPR Products

miRNA for STK26 Gene

miRTarBase miRNAs that target STK26

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for STK26

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK26 Gene

Localization for STK26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK26 Gene

Cytoplasm. Golgi apparatus. Note=Colocalized with RIPOR1 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with RIPOR1 upon serum stimulation in a Rho- and PDCD10-dependent manner (PubMed:27807006). {ECO:0000269 PubMed:27807006}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK26 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
golgi apparatus 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Centrosome (2)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STK26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA,IDA 17360971
GO:0005794 Golgi apparatus IEA,IDA 15037601
GO:0005798 Golgi-associated vesicle IDA 22797597
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STK26: view

Pathways & Interactions for STK26 Gene

genes like me logo Genes that share pathways with STK26: view

Pathways by source for STK26 Gene

1 Cell Signaling Technology pathway for STK26 Gene
1 BioSystems pathway for STK26 Gene

SIGNOR curated interactions for STK26 Gene

Activates:

Gene Ontology (GO) - Biological Process for STK26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000185 activation of MAPKKK activity IEA --
GO:0006468 protein phosphorylation IMP 22291017
GO:0006915 apoptotic process IEA --
GO:0007346 regulation of mitotic cell cycle IBA --
genes like me logo Genes that share ontologies with STK26: view

Drugs & Compounds for STK26 Gene

(3) Drugs for STK26 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE Experimental Pharma Target 0
ATP Nutra Agonist 0
Magnesium Nutra 0

(1) Additional Compounds for STK26 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK26: view

Transcripts for STK26 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for STK26

Alternative Splicing Database (ASD) splice patterns (SP) for STK26 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a ·
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - -
SP7: - - - - - - -
SP8: - - -
SP9: - - - - - -
SP10: - - -
SP11: - -
SP12: -

ExUns: 14b ^ 15a · 15b · 15c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for STK26 Gene

GeneLoc Exon Structure for
STK26
ECgene alternative splicing isoforms for
STK26

Expression for STK26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STK26 Gene

Protein differential expression in normal tissues from HIPED for STK26 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.8) and Tlymphocyte (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STK26 Gene



Protein tissue co-expression partners for STK26 Gene

NURSA nuclear receptor signaling pathways regulating expression of STK26 Gene:

STK26

Evidence on tissue expression from TISSUES for STK26 Gene

  • Nervous system(4.7)
  • Liver(4.2)
  • Lung(2.2)
  • Gall bladder(2.1)
  • Intestine(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with STK26: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK26 Gene

Orthologs for STK26 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK26 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
OneToOne
MST4 33
  • 95.59 (n)
chimpanzee
(Pan troglodytes)
Mammalia MST4 33
  • 99.76 (n)
-- 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MST4 33 34
  • 93.43 (n)
mouse
(Mus musculus)
Mammalia 2610018G03Rik 34 33
  • 91.11 (n)
OneToOne
Stk26 16
rat
(Rattus norvegicus)
Mammalia Mst4 33
  • 90.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves MST4 33 34
  • 83.05 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mst4 33
  • 78.29 (n)
Str.19684 33
zebrafish
(Danio rerio)
Actinopterygii mst4 33 34
  • 69.02 (n)
fruit fly
(Drosophila melanogaster)
Insecta GckIII 33 34
  • 69.08 (n)
worm
(Caenorhabditis elegans)
Secernentea gck-1 34
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPS1 34
  • 30 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.10170 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4671 34
  • 64 (a)
OneToMany
Species where no ortholog for STK26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK26 Gene

ENSEMBL:
Gene Tree for STK26 (if available)
TreeFam:
Gene Tree for STK26 (if available)

Paralogs for STK26 Gene

Paralogs for STK26 Gene

Pseudogenes.org Pseudogenes for STK26 Gene

genes like me logo Genes that share paralogs with STK26: view

Variants for STK26 Gene

Sequence variations from dbSNP and Humsavar for STK26 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_040845 A gastric adenocarcinoma sample
rs1000039481 -- 132,053,722(+) TGGCA(A/G)GGTTG intron-variant, splice-acceptor-variant
rs1000244130 -- 132,023,838(+) CTAGG(C/T)AGTGC intron-variant
rs1000248310 -- 132,028,571(+) GGACT(A/G)GAGAC intron-variant
rs1000255842 -- 132,039,522(+) ATTCT(A/G)CTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK26 Gene

Variant ID Type Subtype PubMed ID
nsv515171 CNV gain 21397061
nsv425419 CNV deletion 16902084
esv3574575 CNV loss 25503493
esv3574574 CNV loss 25503493

Variation tolerance for STK26 Gene

Residual Variation Intolerance Score: 19.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK26 Gene

Disorders for STK26 Gene

Relevant External Links for STK26

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK26

No disorders were found for STK26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK26 Gene

Publications for STK26 Gene

  1. Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties. (PMID: 11741893) Dan I … Pandey A (The Journal of biological chemistry 2002) 3 4 22 60
  2. Cloning and characterization of MST4, a novel Ste20-like kinase. (PMID: 11306563) Qian Z … Rosner MR (The Journal of biological chemistry 2001) 2 3 4 60
  3. RHO binding to FAM65A regulates Golgi reorientation during cell migration. (PMID: 27807006) Mardakheh FK … Marshall CJ (Journal of cell science 2016) 3 4 60
  4. CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation. (PMID: 20332113) Fidalgo M … Zalvide J (Journal of cell science 2010) 3 4 60
  5. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M … Gingras AC (Molecular & cellular proteomics : MCP 2009) 3 4 60

Products for STK26 Gene

  • Addgene plasmids for STK26

Sources for STK26 Gene

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