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STK25 Gene

protein-coding   GIFtS: 63
GCID: GC02M242434

Serine/Threonine Kinase 25

(Previous names: serine/threonine kinase 25 (Ste20, yeast homolog))
  See STK25-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Threonine Kinase 251 2     EC 2.7.11.13 8
Ste20-Like Kinase2 3     Serine/Threonine Kinase 25 (Ste20, Yeast Homolog)1
Ste20/Oxidant Stress Response Kinase 12 3     Serine/Threonine-Protein Kinase 252
Sterile 20/Oxidant Stress-Response Kinase 12 3     Ste20, Yeast Homolog2
SOK12 3     SOK-13
YSK12 3     EC 2.7.118

External Ids:    HGNC: 114041   Entrez Gene: 104942   Ensembl: ENSG000001156947   OMIM: 6022555   UniProtKB: O005063   

Export aliases for STK25 gene to outside databases

Previous GC identifers: GC02P238953 GC02P239845 GC02M242453 GC02M242755 GC02M242154 GC02M234189


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STK25 Gene:
This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of
kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate
neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus
to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene
associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have
been observed for this gene. (provided by RefSeq, Dec 2012)

GeneCards Summary for STK25 Gene:
STK25 (serine/threonine kinase 25) is a protein-coding gene. Diseases associated with STK25 include pseudopseudohypoparathyroidism, and anoxia. GO annotations related to this gene include protein kinase activity and identical protein binding. An important paralog of this gene is STK24.

UniProtKB/Swiss-Prot: STK25_HUMAN, O00506
Function: Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental
stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and
polarity complexes important for cell migration

Gene Wiki entry for STK25 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STK25 gene promoter:
         p53   AML1a   Lmo2   XBP-1   CUTL1   LUN-1   SRY   c-Myb   Pax-4a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK25 promoter sequence
   Search Chromatin IP Primers for STK25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

STK25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK25 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M242434:  view genomic region     (about GC identifiers)

Start:
242,432,089 bp from pter      End:
242,449,145 bp from pter
Size:
17,057 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: STK25_HUMAN, O00506 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 25  
Size: 426 amino acids; 48112 Da
Cofactor: Magnesium
Subunit: Homodimer. Interacts with CTTNBP2NL
2 PDB 3D structures from and Proteopedia for STK25:
2XIK (3D)        3W8H (3D)    
Secondary accessions: A8K7D2 Q15522 Q5BJF1

Explore the universe of human proteins at neXtProt for STK25: NX_O00506

Explore proteomics data for STK25 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys155, Lys171
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for STK25 (O00506) (see all 14)
     LLKHKFI  GITAIEL  LDYLHSE  WMAPEVI 


    See STK25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001258906.1  NP_001258907.1  NP_001258908.1  NP_001258909.1  NP_001269234.1  NP_001269235.1  NP_001269236.1  NP_001269237.1  
    NP_006365.2  

    ENSEMBL proteins: 
     ENSP00000325748   ENSP00000384162   ENSP00000385687   ENSP00000384444   ENSP00000385541  
     ENSP00000404469   ENSP00000399212   ENSP00000417020   ENSP00000403607   ENSP00000395104  
     ENSP00000404960   ENSP00000412617   ENSP00000403866   ENSP00000401114   ENSP00000406208  
     ENSP00000414191   ENSP00000404552   ENSP00000444886   ENSP00000446008  

    STK25 Human Recombinant Protein Products:

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    Novus Biologicals STK25 Proteins
    Novus Biologicals STK25 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STK25

     
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    antibodies-online proteins for STK25 (4 products) 

     
    antibodies-online peptides for STK25

    STK25 Antibody Products:

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    Abcam antibodies for STK25 (O00506, Q9Y6E0)
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    antibodies-online antibodies for STK25 (48 products) 

    STK25 Assay Products:

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    Cloud-Clone Corp. ELISAs for STK25
    Cloud-Clone Corp. CLIAs for STK25
    Search eBioscience for ELISAs for STK25 
    antibodies-online kits for STK25 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine kinase 25
    YSK subfamily

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O00506

    ProtoNet protein and cluster: O00506

    UniProtKB/Swiss-Prot: STK25_HUMAN, O00506
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with STK25           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STK25_HUMAN, O00506
    Function: Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental
    stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and
    polarity complexes important for cell migration
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-174, possibly
    as a consequence of stabilization of dimer formation. The C-terminal non-catalytic region inhibits the kinase
    activity

         Genatlas biochemistry entry for STK25:
    serine/threonine kinase 25,yeast Sp11/Ste20 related ,widely expressed,activated by oxidant stress,not activated by
    growth factors,alkylating agents,cytokines or environmental stress,not activating the MAPK,ERK or INK pathways

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9160885
    GO:0004702receptor signaling protein serine/threonine kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI15037601
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with STK25           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for STK25:
     Gemcitabine induced cell-death  Paclitaxel antagonistic effect 

         1 MGI phenotypic allele for Stk25 (no phenotypes)

    Find genes that share phenotypes with STK25           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Stk25tm1Lex for STK25

       genOway: Develop your customized and physiologically relevant rodent model for STK25

    miRNA
    Products:
        
    miRTarBase miRNAs that target STK25:
    hsa-mir-92a-3p (MIRT049469), hsa-mir-186-5p (MIRT044928)

    Block miRNA regulation of human, mouse, rat STK25 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate STK25:
    hsa-miR-4261 hsa-miR-101 hsa-miR-296-5p hsa-miR-488 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidSTK25 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STK25

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for STK25

    Clone
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    OriGene clones in human, mouse for STK25 (see all 9)
    OriGene ORF clones in mouse, rat for STK25
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    GenScript: all cDNA clones in your preferred vector: STK25 (NM_006374)
    Sino Biological Human cDNA Clone for STK25
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STK25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK25
    Addgene plasmids for STK25 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK25


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STK25_HUMAN, O00506: Cytoplasm. Golgi apparatus. Note=Localizes to the Golgi apparatus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    cytoskeleton2
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005794Golgi apparatus IEA--

    Find genes that share ontologies with STK25           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STK25 About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sperm Motility0.37

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STK25
        Sperm Motility



        Pathway & Disease-focused RT2 Profiler PCR Array including STK25: 
              Oxidative Stress in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for STK25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STK25 (O005061, 2, 3 ENSP000003257484) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAB39Q9Y3761, 2, 3, ENSP000002584184EBI-618295,EBI-306905 MINT-8186866 MINT-8186834 MINT-8186850 I2D: score=1 STRING: ENSP00000258418
    STRNO438151, 3, ENSP000002639184EBI-618295,EBI-1046642 I2D: score=2 STRING: ENSP00000263918
    UBE2D3P610772, 3, ENSP000003497224MINT-8276163 I2D: score=2 STRING: ENSP00000349722
    PDCD10Q9BUL81, 3EBI-618295,EBI-740195 I2D: score=5 
    GOLGA2Q083791, 3, ENSP000004160974EBI-618295,EBI-618309 I2D: score=4 STRING: ENSP00000416097
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006915apoptotic process IBA--
    GO:0006979response to oxidative stress TAS8887545
    GO:0007163establishment or maintenance of cell polarity IEA--
    GO:0007165signal transduction TAS8887545

    Find genes that share ontologies with STK25           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STK25

    3 HMDB Compounds for STK25    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STK25 gene (9 alternative transcripts): 
    NM_001271977.1  NM_001271978.1  NM_001271979.1  NM_001271980.1  NM_001282305.1  NM_001282306.1  NM_001282307.1  NM_001282308.1  
    NM_006374.4  

    Unigene Cluster for STK25:

    Serine/threonine kinase 25
    Hs.516807  [show with all ESTs]
    Unigene Representative Sequence: CR936874
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 35):
    ENST00000316586(uc002wbn.3 uc002wbo.3 uc010zos.2 uc010zot.2)
    ENST00000472181 ENST00000403346(uc002wbp.3 uc010fzo.3 uc010zou.2)
    ENST00000401869(uc002wbm.3) ENST00000405883 ENST00000494699 ENST00000487962(uc002wbl.3)
    ENST00000405585 ENST00000478403 ENST00000470438 ENST00000465009 ENST00000423004
    ENST00000462953 ENST00000495143 ENST00000461760 ENST00000450497 ENST00000424537
    ENST00000442307
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate STK25:
    hsa-miR-4261 hsa-miR-101 hsa-miR-296-5p hsa-miR-488 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidSTK25 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for STK25 
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat STK25
      QuantiFast Probe-based Assays in human, mouse, rat STK25

    Additional mRNA sequence: 

    AK092161.1 AK291808.1 AK291947.1 AK297374.1 AK301214.1 AK302751.1 AK303719.1 AK315966.1 
    BC007852.2 BC015793.1 BC091505.1 BT019961.1 CR936874.1 D63780.1 NR_073530.1 NR_073531.1 
    NR_073532.1 NR_073533.1 X99325.1 

    Selected DOTS entries (see all 40):

    DT.95312338  DT.100727038  DT.218313  DT.99999966  DT.100881864  DT.100881849  DT.100881852  DT.100032921 
    DT.100759490  DT.95312339  DT.100881854  DT.91767028  DT.100881862  DT.120933011  DT.100881870  DT.101985283 
    DT.100881846  DT.100881850  DT.308577  DT.91767006  DT.100881867  DT.91767007  DT.95312336  DT.100881861 

    Selected AceView cDNA sequences (see all 700):

    BQ925417 CR614826 BM970563 CB215954 CK430483 T33558 BU855885 BE292820 
    AA632262 BM763276 CB250694 BI869852 BU527607 CB123587 AI590399 BQ230668 
    BE408001 BM787832 BQ217473 BU146035 BC007852 BQ960656 AI570139 BQ894611 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STK25 (see all 32)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ·
    SP1:                                                        -     -     -     -                       -     -                             -     -     -     -   
    SP2:                                                              -     -     -                       -     -                             -     -     -     -   
    SP3:                                                              -     -     -                       -     -     -     -     -     -     -     -     -     -   
    SP4:                                                                                                  -     -                             -     -     -     -   
    SP5:                                                                                                                                -     -     -     -     -   

    ExUns: 8c ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b ·
    SP1:  -     -                                   -     -     -     -     -                             -                                                         
    SP2:  -     -                                   -     -     -     -     -                             -                                                         
    SP3:  -     -                                   -     -     -     -     -                             -                                                         
    SP4:  -     -                                   -     -     -     -     -                             -                                                         
    SP5:  -     -                                   -     -     -     -     -                             -                                                         

    ExUns: 14c ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18
    SP1:              -     -     -                     
    SP2:              -     -     -                     
    SP3:              -     -     -                     
    SP4:              -     -     -                     
    SP5:                                                


    ECgene alternative splicing isoforms for STK25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STK25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCCATAG
    STK25 Expression
    About this image


    STK25 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    STK25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STK25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516807

    UniProtKB/Swiss-Prot: STK25_HUMAN, O00506
    Tissue specificity: Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach
    followed by heart and lung

        Pathway & Disease-focused RT2 Profiler PCR Array including STK25: 
              Oxidative Stress in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STK25 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk251 , 5 serine/threonine kinase 25 (yeast)1, 5 89.91(n)1
    98.83(a)1
      1 (47.25 cM)5
    590411  NM_021537.31  NP_067512.31 
     936219025 
    chicken
    (Gallus gallus)
    Aves STK251 serine/threonine kinase 25 80.2(n)
    92.25(a)
      378801  NM_204374.1  NP_989705.1 
    lizard
    (Anolis carolinensis)
    Reptilia STK256
    serine/threonine kinase 25
    91(a)
    1 ↔ 1
    3(30415056-30445338)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX848572.12   -- 80.63(n)    BX848572.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045867.12   -- 77.75(n)    BC045867.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51693 protein amino acid phosphorylation
    receptor signaling protein
    serine/threonine kinase less
    80(a)   89E12   --
    worm
    (Caenorhabditis elegans)
    Secernentea gck-11 , 3 serine/threonine kinase3
    gck-11
    66(a)3
    57.7(n)1
    66.03(a)1
      V(8950405-8958008)3
    1792741  NM_001028970.21  NP_001024141.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPS16
    Putative protein serine/threonine kinase expressed...
    32(a)
    1 → many
    IV(1485566-1487038) YDR523C
    soybean
    (Glycine max)
    eudicotyledons 467979842   -- 73.2(n)  


    ENSEMBL Gene Tree for STK25 (if available)
    TreeFam Gene Tree for STK25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STK25 gene
    STK242  STK42  STK32  MST42  
    Selected SIMAP similar genes for STK25 using alignment to 15 protein entries:     STK25_HUMAN (see all proteins) (see all similar genes):
    DKFZp686J1430    STK24    MST4    PAK2    STK3    MINK1
    MYO3A    KSR1    PAK1    TNIK    STK4    MAP4K3
    MAP4K5    TAOK3    PAK3    MYO3B    MAP4K1    SLK

    Find genes that share paralogs with STK25           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for STK25
    PGOHUM00000235004


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STK25 (see all 463)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1502917661,2
    --234206375(+) GTTGGC/TCAAGC 1 -- us2k10--------
    rs1379553931,2
    --234206430(+) ACAGCA/GTAGCA 1 -- us2k10--------
    rs1884679701,2
    --242434786(+) AGGCGC/TAGCTC 9 -- ut31 nc-transcript-variant0--------
    rs349020041,2
    C,F--242434802(-) CCGGCG/CTGGCC 9 -- ut31 nc-transcript-variant5Minor allele frequency- C:0.01NS 190
    rs128431,2
    C,F--242434803(-) GCCGGC/TGTGGC 9 -- ut31 nc-transcript-variantese31Minor allele frequency- T:0.00MN 184
    rs90521,2
    C,F,A--242434809(-) CCAGCC/AGCCGG 9 -- ut31 nc-transcript-variantese314Minor allele frequency- A:0.19MN NS NA CSA WA EA 928
    rs1423943581,2
    --242434822(+) CCCCCA/GTGAGC 9 -- ut31 nc-transcript-variant0--------
    rs356021661,2
    C--242434903(-) CCTGCA/GGTGTG 9 -- ut31 nc-transcript-variant6Minor allele frequency- G:0.01NS NA 310
    rs353934671,2
    C,F--242435042(-) AGGTCG/ATTTGT 9 -- ut31 nc-transcript-variant7Minor allele frequency- A:0.03NS NA EU 1625
    rs2007817971,2
    C--242435081(+) TTCAGC/TGGGTG 14 H R mis10--------

    HapMap Linkage Disequilibrium report for STK25 (242432089 - 242449145 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for STK25:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876226CNV Loss21882294
    nsv834588CNV Loss17160897
    nsv10229CNV Gain18304495
    dgv1296e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing STK25
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602255    OMIM disorders: --

    2 diseases for STK25:    
    About MalaCards
    pseudopseudohypoparathyroidism    anoxia

    1 disease from the University of Copenhagen DISEASES database for STK25:
    Pseudopseudohypoparathyroidism

    Find genes that share disorders with STK25           About GenesLikeMe


    Export disorders for STK25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STK25 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with STK25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway. (PubMed id 8887545)1, 2, 3, 9 Pombo C.M.... Force T. (EMBO J. 1996)
    2. YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta. (PubMed id 15037601)1, 2, 3 Preisinger C.... Barr F.A. (J. Cell Biol. 2004)
    3. YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways. (PubMed id 9160885)1, 2, 3 Osada S.... Ohno S. (Oncogene 1997)
    4. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PubMed id 18782753)1, 2 Goudreault M.... Gingras A.C. (Mol. Cell. Proteomics 2009)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations. (PubMed id 17657516)1, 9 Voss K....Felbor U. (Neurogenetics 2007)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions. (PubMed id 23889253)1 Sugden P.H....Clerk A. (Biochem. J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10494 HGNC: 11404 AceView: STK25 Ensembl:ENSG00000115694 euGenes: HUgn10494
    ECgene: STK25 H-InvDB: STK25

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STK25 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/stk25/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STK25 gene:
    Search GeneIP for patents involving STK25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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