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Aliases for STK25 Gene

Aliases for STK25 Gene

  • Serine/Threonine Kinase 25 2 3
  • Sterile 20/Oxidant Stress-Response Kinase 1 3 4
  • Ste20/Oxidant Stress Response Kinase 1 3 4
  • STE20-Like Kinase 3 4
  • EC 2.7.11.1 4 63
  • SOK1 3 4
  • YSK1 3 4
  • Serine/Threonine Kinase 25 (Ste20, Yeast Homolog) 2
  • Serine/Threonine-Protein Kinase 25 3
  • Ste20, Yeast Homolog 3
  • EC 2.7.11 63
  • SOK-1 4

External Ids for STK25 Gene

Previous GeneCards Identifiers for STK25 Gene

  • GC02P238953
  • GC02P239845
  • GC02M242453
  • GC02M242755
  • GC02M242154
  • GC02M234189
  • GC02M242434

Summaries for STK25 Gene

Entrez Gene Summary for STK25 Gene

  • This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for STK25 Gene

STK25 (Serine/Threonine Kinase 25) is a Protein Coding gene. Diseases associated with STK25 include pseudopseudohypoparathyroidism and anoxia. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is STK4.

UniProtKB/Swiss-Prot for STK25 Gene

  • Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.

Gene Wiki entry for STK25 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK25 Gene

Genomics for STK25 Gene

Regulatory Elements for STK25 Gene

Genomic Location for STK25 Gene

Start:
241,492,674 bp from pter
End:
241,509,730 bp from pter
Size:
17,057 bases
Orientation:
Minus strand

Genomic View for STK25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STK25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK25 Gene

Proteins for STK25 Gene

  • Protein details for STK25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00506-STK25_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 25
    Protein Accession:
    O00506
    Secondary Accessions:
    • A8K6Z3
    • A8K7D2
    • B7Z9K1
    • Q15522
    • Q5BJF1

    Protein attributes for STK25 Gene

    Size:
    426 amino acids
    Molecular mass:
    48112 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. Interacts with CTTNBP2NL.

    Three dimensional structures from OCA and Proteopedia for STK25 Gene

    Alternative splice isoforms for STK25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK25 Gene

Proteomics data for STK25 Gene at MOPED

Post-translational modifications for STK25 Gene

  • Ubiquitination at Lys155 and Lys171
  • Modification sites at PhosphoSitePlus

Domains for STK25 Gene

Gene Families for STK25 Gene

Protein Domains for STK25 Gene

Graphical View of Domain Structure for InterPro Entry

O00506

UniProtKB/Swiss-Prot:

STK25_HUMAN :
  • O00506
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STK25: view

Function for STK25 Gene

Molecular function for STK25 Gene

GENATLAS Biochemistry: serine/threonine kinase 25,yeast Sp11/Ste20 related ,widely expressed,activated by oxidant stress,not activated by growth factors,alkylating agents,cytokines or environmental stress,not activating the MAPK,ERK or INK pathways
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-174, possibly as a consequence of stabilization of dimer formation. The C-terminal non-catalytic region inhibits the kinase activity.
UniProtKB/Swiss-Prot Function: Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.

Enzyme Numbers (IUBMB) for STK25 Gene

Gene Ontology (GO) - Molecular Function for STK25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 9160885
GO:0004674 protein serine/threonine kinase activity --
GO:0004702 receptor signaling protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 15037601
genes like me logo Genes that share ontologies with STK25: view

Phenotypes for STK25 Gene

genes like me logo Genes that share phenotypes with STK25: view

miRNA for STK25 Gene

miRTarBase miRNAs that target STK25

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for STK25 Gene

Localization for STK25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK25 Gene

Cytoplasm. Golgi apparatus. Note=Localizes to the Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK25 Gene COMPARTMENTS Subcellular localization image for STK25 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for STK25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22652780
GO:0005794 colocalizes_with Golgi apparatus IDA 22652780
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with STK25: view

Pathways for STK25 Gene

SuperPathways for STK25 Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK25: view

Pathways by source for STK25 Gene

1 Qiagen pathway for STK25 Gene

Gene Ontology (GO) - Biological Process for STK25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 17657516
GO:0006915 apoptotic process IBA --
GO:0006979 response to oxidative stress TAS 8887545
GO:0007163 establishment or maintenance of cell polarity IEA --
GO:0007165 signal transduction TAS 8887545
genes like me logo Genes that share ontologies with STK25: view

Compounds for STK25 Gene

(3) HMDB Compounds for STK25 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with STK25: view

Transcripts for STK25 Gene

Unigene Clusters for STK25 Gene

Serine/threonine kinase 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK25 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6:
SP7: - - - - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - -
SP12: - -
SP13:
SP14:
SP15: - - - - - - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - -
SP18: - - - - - - - - - -
SP19: - - - - - - - - - -
SP20:
SP21: - - - - - - - - - - - - - - - - - - -
SP22: - - - - - - - - -
SP23: - - - - - - - - -
SP24: - - - - - - - - - -
SP25: - - - - - -
SP26: - - - - -
SP27: - - - - - - - -
SP28:
SP29: - - - - - -
SP30: - - - - -
SP31: - - - - -
SP32:

ExUns: 8c ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - -
SP13:
SP14:
SP15: - - - - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - - -
SP18: - - - - - - - - - - -
SP19: - - - - - - - - - - - - - -
SP20: -
SP21: - -
SP22:
SP23: -
SP24: - - - - - - -
SP25: - -
SP26: - -
SP27: - -
SP28:
SP29:
SP30:
SP31: - -
SP32:

ExUns: 14c ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28: - -
SP29:
SP30:
SP31:
SP32:

Relevant External Links for STK25 Gene

GeneLoc Exon Structure for
STK25
ECgene alternative splicing isoforms for
STK25

Expression for STK25 Gene

mRNA expression in normal human tissues for STK25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK25 Gene

This gene is overexpressed in Muscle - Skeletal (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STK25 Gene

SOURCE GeneReport for Unigene cluster for STK25 Gene Hs.516807

mRNA Expression by UniProt/SwissProt for STK25 Gene

O00506-STK25_HUMAN
Tissue specificity: Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung
genes like me logo Genes that share expressions with STK25: view

Orthologs for STK25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STK25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK25 35
  • 98.98 (n)
  • 99.53 (a)
STK25 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STK25 35
  • 89.31 (n)
  • 94.58 (a)
STK25 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK25 35
  • 91.16 (n)
  • 97.42 (a)
STK25 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk25 35
  • 89.91 (n)
  • 98.83 (a)
Stk25 16
Stk25 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK25 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk25 35
  • 89.98 (n)
  • 98.83 (a)
chicken
(Gallus gallus)
Aves STK25 35
  • 80.2 (n)
  • 92.25 (a)
STK25 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK25 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk25 35
  • 73.91 (n)
  • 81.82 (a)
zebrafish
(Danio rerio)
Actinopterygii stk25a 36
  • 79 (a)
OneToMany
stk25b 35
  • 76.73 (n)
  • 83.25 (a)
stk25b 36
  • 83 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta GckIII 36
  • 41 (a)
OneToMany
CG5169 37
  • 80 (a)
worm
(Caenorhabditis elegans)
Secernentea gck-1 35
  • 57.7 (n)
  • 66.03 (a)
gck-1 36
  • 31 (a)
OneToMany
gck-1 37
  • 66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPS1 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4671 36
  • 67 (a)
OneToMany
Species with no ortholog for STK25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK25 Gene

ENSEMBL:
Gene Tree for STK25 (if available)
TreeFam:
Gene Tree for STK25 (if available)

Paralogs for STK25 Gene

Paralogs for STK25 Gene

Pseudogenes.org Pseudogenes for STK25 Gene

genes like me logo Genes that share paralogs with STK25: view

Variants for STK25 Gene

Sequence variations from dbSNP and Humsavar for STK25 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs879506 -- 241,497,453(-) AATCT(A/G)CTGCA intron-variant
rs905660 -- 241,505,343(+) GCACC(C/T)GGAAA intron-variant
rs905661 -- 241,505,625(+) CCCGG(A/T)AGGGA intron-variant
rs905663 -- 241,496,331(-) TGAGG(C/T)CCAGT intron-variant
rs1135066 -- 241,499,154(-) CTGGG(C/G)ATCAC synonymous-codon, reference, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for STK25 Gene

Variant ID Type Subtype PubMed ID
nsv876226 CNV Loss 21882294
dgv1296e1 CNV Complex 17122850
nsv834588 CNV Loss 17160897
nsv10229 CNV Gain 18304495

Relevant External Links for STK25 Gene

HapMap Linkage Disequilibrium report
STK25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK25 Gene

Disorders for STK25 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for STK25 Gene including...

Search for STK25 Gene in MalaCards »

(1) University of Copenhagen DISEASES for STK25 Gene

genes like me logo Genes that share disorders with STK25: view

No data available for UniProtKB/Swiss-Prot for STK25 Gene

Publications for STK25 Gene

  1. Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway. (PMID: 8887545) Pombo C.M. … Force T. (EMBO J. 1996) 2 3 4 23
  2. YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways. (PMID: 9160885) Osada S. … Ohno S. (Oncogene 1997) 2 3 4
  3. YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta. (PMID: 15037601) Preisinger C. … Barr F.A. (J. Cell Biol. 2004) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for STK25 Gene

  • Addgene plasmids for STK25

Sources for STK25 Gene

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