Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STK25 Gene

Aliases for STK25 Gene

  • Serine/Threonine Kinase 25 2 3 5
  • Sterile 20/Oxidant Stress-Response Kinase 1 3 4
  • Ste20/Oxidant Stress Response Kinase 1 3 4
  • STE20-Like Kinase 3 4
  • EC 2.7.11.1 4 61
  • SOK1 3 4
  • YSK1 3 4
  • Serine/Threonine Kinase 25 (Ste20, Yeast Homolog) 2
  • Serine/Threonine-Protein Kinase 25 3
  • Ste20, Yeast Homolog 3
  • EC 2.7.11 61
  • SOK-1 4

External Ids for STK25 Gene

Previous GeneCards Identifiers for STK25 Gene

  • GC02P238953
  • GC02P239845
  • GC02M242453
  • GC02M242755
  • GC02M242154
  • GC02M234189
  • GC02M242434

Summaries for STK25 Gene

Entrez Gene Summary for STK25 Gene

  • This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for STK25 Gene

STK25 (Serine/Threonine Kinase 25) is a Protein Coding gene. Diseases associated with STK25 include Cerebral Cavernous Malformations-2. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is STK24.

UniProtKB/Swiss-Prot for STK25 Gene

  • Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.

Gene Wiki entry for STK25 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK25 Gene

Genomics for STK25 Gene

Regulatory Elements for STK25 Gene

Enhancers for STK25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G241558 1.2 FANTOM5 ENCODE 11.7 -50.0 -49971 3.4 FOXA2 ARID4B SIN3A ZNF48 YY1 ZNF263 SP5 MXD4 NFYC REST BOK STK25 ANO7 PASK PPP1R7 ING5 ATG4B NEU4 BOK-AS1 LOC105373975
GH02G241372 1.1 ENCODE dbSUPER 10.8 +135.7 135674 3.9 PKNOX1 TBL1XR1 KLF17 BMI1 NFXL1 RAD21 SCRT2 FOS RCOR1 ETV6 HDLBP ANO7 SEPT2 STK25 PASK PPP1R7 ENSG00000234793 D2HGDH LOC105373973 PIR56981
GH02G241678 0.9 Ensembl ENCODE 10.7 -171.3 -171292 4.3 JUN BHLHE40 SIN3A ZNF121 ZFHX2 JUND POLR2A ZNF341 FOS MAFK ING5 ATG4B STK25 ENSG00000235351 BOK LINC01238 D2HGDH DTYMK GC02M241661
GH02G241479 0.7 ENCODE 11.5 +30.1 30095 1.1 ELF3 SOX13 TBP DRAP1 TFAP4 SAP130 ZSCAN9 POLR2A NCOR1 THAP11 FARP2 STK25 SEPT2 ANO7 LOC101930137 LOC100422094
GH02G241425 0.3 FANTOM5 9.7 +84.0 83975 0.2 STK25 ANO7 ING5 GC02P241444 PIR56981 LOC105373973
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STK25 on UCSC Golden Path with GeneCards custom track

Promoters for STK25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000133284 1430 1801 HDGF MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 ZNF766

Genomic Location for STK25 Gene

Chromosome:
2
Start:
241,492,674 bp from pter
End:
241,509,730 bp from pter
Size:
17,057 bases
Orientation:
Minus strand

Genomic View for STK25 Gene

Genes around STK25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK25 Gene

Proteins for STK25 Gene

  • Protein details for STK25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00506-STK25_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 25
    Protein Accession:
    O00506
    Secondary Accessions:
    • A8K6Z3
    • A8K7D2
    • B7Z9K1
    • Q15522
    • Q5BJF1

    Protein attributes for STK25 Gene

    Size:
    426 amino acids
    Molecular mass:
    48112 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. Interacts with CTTNBP2NL.

    Three dimensional structures from OCA and Proteopedia for STK25 Gene

    Alternative splice isoforms for STK25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK25 Gene

Selected DME Specific Peptides for STK25 Gene

O00506:
  • IGKGSFGEV
  • VAIKIID
  • GITAIEL
  • GTPFWMAP
  • WMAPEVI
  • KLWIIMEYL
  • AEDEIEDIQQEI
  • HRDIKAAN
  • IHRDIKAAN
  • LLKHKFI
  • KADIWSLGIT
  • LDYLHSE
  • ADFGVAGQLTDT
  • VKLADFG

Post-translational modifications for STK25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for STK25 Gene

Gene Families for STK25 Gene

Protein Domains for STK25 Gene

Graphical View of Domain Structure for InterPro Entry

O00506

UniProtKB/Swiss-Prot:

STK25_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STK25: view

Function for STK25 Gene

Molecular function for STK25 Gene

GENATLAS Biochemistry:
serine/threonine kinase 25,yeast Sp11/Ste20 related ,widely expressed,activated by oxidant stress,not activated by growth factors,alkylating agents,cytokines or environmental stress,not activating the MAPK,ERK or INK pathways
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-174, possibly as a consequence of stabilization of dimer formation. The C-terminal non-catalytic region inhibits the kinase activity.
UniProtKB/Swiss-Prot Function:
Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.

Enzyme Numbers (IUBMB) for STK25 Gene

Gene Ontology (GO) - Molecular Function for STK25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,TAS 9160885
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 15037601
genes like me logo Genes that share ontologies with STK25: view
genes like me logo Genes that share phenotypes with STK25: view

Animal Models for STK25 Gene

MGI Knock Outs for STK25:

Animal Model Products

  • Taconic Biosciences Mouse Models for STK25

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK25 Gene

Localization for STK25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK25 Gene

Cytoplasm. Golgi apparatus. Note=Localizes to the Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK25 gene
Compartment Confidence
extracellular 5
cytosol 3
golgi apparatus 3
nucleus 2

Gene Ontology (GO) - Cellular Components for STK25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA,IDA 22652780
GO:0005794 colocalizes_with Golgi apparatus IEA,IDA 22652780
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with STK25: view

Pathways & Interactions for STK25 Gene

SuperPathways for STK25 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK25: view

Pathways by source for STK25 Gene

1 Qiagen pathway for STK25 Gene

SIGNOR curated interactions for STK25 Gene

Other effect:

Gene Ontology (GO) - Biological Process for STK25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 17657516
GO:0006979 response to oxidative stress TAS 8887545
GO:0007163 establishment or maintenance of cell polarity IEA --
GO:0007165 signal transduction TAS 8887545
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with STK25: view

Drugs & Compounds for STK25 Gene

(1) Drugs for STK25 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with STK25: view

Transcripts for STK25 Gene

Unigene Clusters for STK25 Gene

Serine/threonine kinase 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK25 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6:
SP7: - - - - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - -
SP12: - -
SP13:
SP14:
SP15: - - - - - - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - -
SP18: - - - - - - - - - -
SP19: - - - - - - - - - -
SP20:
SP21: - - - - - - - - - - - - - - - - - - -
SP22: - - - - - - - - -
SP23: - - - - - - - - -
SP24: - - - - - - - - - -
SP25: - - - - - -
SP26: - - - - -
SP27: - - - - - - - -
SP28:
SP29: - - - - - -
SP30: - - - - -
SP31: - - - - -
SP32:

ExUns: 8c ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - -
SP13:
SP14:
SP15: - - - - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - - -
SP18: - - - - - - - - - - -
SP19: - - - - - - - - - - - - - -
SP20: -
SP21: - -
SP22:
SP23: -
SP24: - - - - - - -
SP25: - -
SP26: - -
SP27: - -
SP28:
SP29:
SP30:
SP31: - -
SP32:

ExUns: 14c ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28: - -
SP29:
SP30:
SP31:
SP32:

Relevant External Links for STK25 Gene

GeneLoc Exon Structure for
STK25
ECgene alternative splicing isoforms for
STK25

Expression for STK25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STK25 Gene

mRNA differential expression in normal tissues according to GTEx for STK25 Gene

This gene is overexpressed in Muscle - Skeletal (x4.4).

Protein differential expression in normal tissues from HIPED for STK25 Gene

This gene is overexpressed in Saliva (33.9), Lung (9.8), and Cervix (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STK25 Gene



NURSA nuclear receptor signaling pathways regulating expression of STK25 Gene:

STK25

SOURCE GeneReport for Unigene cluster for STK25 Gene:

Hs.516807

mRNA Expression by UniProt/SwissProt for STK25 Gene:

O00506-STK25_HUMAN
Tissue specificity: Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung.

Evidence on tissue expression from TISSUES for STK25 Gene

  • Nervous system(4.9)
  • Eye(3.4)
  • Lung(3.2)
  • Pancreas(3)
  • Liver(2.8)
  • Muscle(2.8)
genes like me logo Genes that share expression patterns with STK25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK25 Gene

Orthologs for STK25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STK25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK25 34 35
  • 98.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STK25 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK25 34 35
  • 91.16 (n)
rat
(Rattus norvegicus)
Mammalia Stk25 34
  • 89.98 (n)
mouse
(Mus musculus)
Mammalia Stk25 34 16 35
  • 89.91 (n)
cow
(Bos Taurus)
Mammalia STK25 34 35
  • 89.31 (n)
chicken
(Gallus gallus)
Aves STK25 34 35
  • 80.2 (n)
lizard
(Anolis carolinensis)
Reptilia STK25 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk25 34
  • 73.91 (n)
zebrafish
(Danio rerio)
Actinopterygii stk25a 35
  • 79 (a)
OneToMany
stk25b 34 35
  • 76.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5169 36
  • 80 (a)
GckIII 35
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gck-1 36 34 35
  • 57.7 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPS1 35
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4671 35
  • 67 (a)
OneToMany
Species where no ortholog for STK25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK25 Gene

ENSEMBL:
Gene Tree for STK25 (if available)
TreeFam:
Gene Tree for STK25 (if available)

Paralogs for STK25 Gene

Paralogs for STK25 Gene

Pseudogenes.org Pseudogenes for STK25 Gene

genes like me logo Genes that share paralogs with STK25: view

Variants for STK25 Gene

Sequence variations from dbSNP and Humsavar for STK25 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000073223 -- 241,503,142(+) CACTG(C/T)AACCT intron-variant
rs1000129235 -- 241,504,589(+) GCACA(C/G)ATGAG intron-variant
rs1000319625 -- 241,508,972(+) GGTTC(C/G)AGCGG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000386076 -- 241,511,427(+) GGGAC(C/G)TGCCC upstream-variant-2KB
rs1000569589 -- 241,496,759(+) CTTCC(C/T)CCTAC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for STK25 Gene

Variant ID Type Subtype PubMed ID
esv2759120 CNV loss 17122850
nsv10229 CNV gain 18304495
nsv1109345 CNV deletion 24896259
nsv834588 CNV loss 17160897

Variation tolerance for STK25 Gene

Residual Variation Intolerance Score: 10.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK25 Gene

Disorders for STK25 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STK25 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cerebral cavernous malformations-2
  • cerebral cavernous malformation 2
- elite association - COSMIC cancer census association via MalaCards
Search STK25 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STK25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK25
genes like me logo Genes that share disorders with STK25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK25 Gene

Publications for STK25 Gene

  1. Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway. (PMID: 8887545) Pombo C.M. … Force T. (EMBO J. 1996) 2 3 4 22 64
  2. YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta. (PMID: 15037601) Preisinger C. … Barr F.A. (J. Cell Biol. 2004) 2 3 4 64
  3. YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways. (PMID: 9160885) Osada S. … Ohno S. (Oncogene 1997) 2 3 4 64
  4. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M. … Gingras A.C. (Mol. Cell. Proteomics 2009) 3 4 64
  5. CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations. (PMID: 17657516) Voss K. … Felbor U. (Neurogenetics 2007) 3 22 64

Products for STK25 Gene

  • Addgene plasmids for STK25

Sources for STK25 Gene

Content
Loading form....