STK25 Gene
protein-coding GIFtS: 60
GCID: GC02M242453
|
|
serine/threonine kinase 25(Previous names: serine/threonine kinase 25 (Ste20, yeast homolog) )
| |
Aliases
for STK25 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine/Threonine Kinase 251 2 | | EC 2.7.11.13 8 | | SOK11 2 3 | | Serine/Threonine Kinase 25 (Ste20, Yeast Homolog)1 | | YSK11 2 3 | | Serine/Threonine-Protein Kinase 252 | | Ste20-Like Kinase2 3 | | Ste20, Yeast Homolog2 | | Ste20/Oxidant Stress Response Kinase 12 3 | | SOK-13 | | Sterile 20/Oxidant Stress-Response Kinase 12 3 | | EC 2.7.118 |
Export aliases for STK25 gene to outside databasesPrevious GC identifers: GC02P238953 GC02P239845 GC02M242755 GC02M242154 GC02M234189 |
Summaries
for STK25 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for STK25:
This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily ofkinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulateneuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus tothe nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated withthis gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for thisgene. (provided by RefSeq, Dec 2012)
UniProtKB/Swiss-Prot: STK25_HUMAN, O00506Function: Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmentalstress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, andpolarity complexes important for cell migration
Gene Wiki entry for STK25
|
Genomic Views
for STK25 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005416.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STK25 gene promoter:
p53 AML1a Lmo2 XBP-1 CUTL1 LUN-1 SRY c-Myb Pax-4a NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for STK25
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK25 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q37.3 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2q37.3STK25 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M242453: view genomic region
(about GC identifiers)
Start:
|
242,432,089 bp from pter |
End:
|
242,449,145 bp from pter |
Size:
|
17,057 bases |
Orientation:
|
minus strand |
|
Proteins
for STK25 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STK25_HUMAN, O00506 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase 25 Size: 426 amino acids; 48112 Da
Cofactor: Magnesium
Subunit: Homodimer
Subcellular location: Cytoplasm. Golgi apparatus. Note=Localizes to the Golgi apparatus
1 PDB 3D structure from  and Proteopedia  for STK25:2XIK (3D)
Secondary accessions: A8K7D2 Q15522 Q5BJF1Explore the universe of human proteins at neXtProt for STK25: NX_O00506
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00506
4/14 DME Specific Peptides for STK25 (O00506) (see all 14)
STK25 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001258906.1 NP_001258907.1 NP_001258908.1 NP_001258909.1 NP_006365.2
ENSEMBL proteins: ENSP00000325748 ENSP00000384162 ENSP00000385687 ENSP00000384444 ENSP00000385541 ENSP00000404469 ENSP00000399212 ENSP00000417020 ENSP00000403607 ENSP00000395104 ENSP00000404960 ENSP00000412617 ENSP00000403866 ENSP00000401114 ENSP00000406208 ENSP00000414191 ENSP00000404552 ENSP00000444886 ENSP00000446008
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005794 | Golgi apparatus |
IEA | -- |
STK25 for ontologies About GeneDecksing
STK25 Antibody Products:
Assay Products for STK25: |
Protein
Domains /
Families
for STK25 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STK25 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00506ProtoNet protein and cluster: O00506 UniProtKB/Swiss-Prot: STK25_HUMAN, O00506Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamilySimilarity: Contains 1 protein kinase domain |
Function
for STK25 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STK25_HUMAN, O00506Function: Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmentalstress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, andpolarity complexes important for cell migrationCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-174, possibly as aconsequence of stabilization of dimer formation. The C-terminal non-catalytic region inhibits the kinase activity Genatlas biochemistry entry for STK25:serine/threonine kinase 25,yeast Sp11/Ste20 related ,widely expressed,activated by oxidant stress,not activated bygrowth factors,alkylating agents,cytokines or environmental stress,not activating the MAPK,ERK or INK pathways
Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK25 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK25 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: STK25 (NM_006374) | |  | Sino Biological Human cDNA Clone for STK25 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STK25 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK25 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK25 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
STK25 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for STK25:
Animal Models:
Mouse knock-out Stk25tm1Lex for STK25
1 MGI phenotypic allele  for Stk25 (no phenotypes)
STK25 for phenotypes About GeneDecksing
|
Pathways & Interactions
for STK25 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sweet Taste Signaling | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for STK25
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STK25
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/34 Interacting proteins for STK25 (O005061, 2, 3 ENSP000003257484) via UniProtKB, MINT, STRING, and/or I2D (see all 34)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CAB39 | Q9Y3762, 3, ENSP000002584184 | MINT-8186866 MINT-8186834 MINT-8186850 I2D:
score=1 STRING: ENSP00000258418 | | STRN | O438151, 3, ENSP000002639184 | EBI-5773834,EBI-1046642 I2D:
score=2 STRING: ENSP00000263918 | | UBE2D3 | P610772, 3, ENSP000003497224 | MINT-8276163 I2D:
score=2 STRING: ENSP00000349722 | | PDCD10 | Q9BUL81, 3 | EBI-5773834,EBI-2556229 I2D:
score=5 | | YWHAZ | P631041, 3, ENSP000003095034 | EBI-5773834,EBI-347088 I2D:
score=3 STRING: ENSP00000309503 |
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
STK25 for ontologies About GeneDecksing
|
Drugs & Compounds
for STK25 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STK25
3 HMDB Compounds for STK25 About this table
Search CenterWatch for drugs/clinical trials and news about STK25
|
Transcripts
for STK25 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STK25 gene (5 alternative transcripts): NM_001271977.1 NM_001271978.1 NM_001271979.1 NM_001271980.1 NM_006374.4 Unigene Cluster for STK25: Serine/threonine kinase 25 Hs.516807 [show with all ESTs]Unigene Representative Sequence: CR93687418/35 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 35): ENST00000316586(uc002wbn.3 uc002wbo.3 uc010zos.2 uc010zot.2)
ENST00000472181 ENST00000403346(uc002wbp.3 uc010fzo.3 uc010zou.2)
ENST00000401869(uc002wbm.3) ENST00000405883 ENST00000494699 ENST00000487962(uc002wbl.3)
ENST00000405585 ENST00000478403 ENST00000470438 ENST00000465009 ENST00000423004
ENST00000462953 ENST00000495143 ENST00000461760 ENST00000450497 ENST00000424537
ENST00000442307
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK25 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK25 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STK25 (NM_006374) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STK25 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK25 |
Additional cDNA sequence: AK092161.1 AK291808.1 AK291947.1 AK297374.1 AK301214.1 AK302751.1 AK303719.1 AK315966.1 BC007852.2 BC015793.1 BC091505.1 BT019961.1 CR936874.1 D63780.1 NR_073530.1 NR_073531.1 NR_073532.1 NR_073533.1 X99325.1 24/40 DOTS entries (see all 40): DT.95312338 DT.100727038 DT.218313 DT.99999966 DT.100881864 DT.100881849 DT.100881852 DT.100032921 DT.100759490 DT.95312339 DT.100881854 DT.91767028 DT.100881862 DT.120933011 DT.100881870 DT.101985283 DT.100881846 DT.100881850 DT.308577 DT.91767006 DT.100881867 DT.91767007 DT.95312336 DT.100881861 24/700 AceView cDNA sequences (see all 700): CA430197 BQ647220 BE281168 BG425688 BG828942 BE267793 CB853215 BM558223 BE272035 BQ649788 BE902419 BM910744 BQ427497 BM810504 F11376 BU197213 BQ654016 AI377105 CR614826 BM910582 BQ674771 BM672886 BX509564 CD171748
GeneLoc Exon Structure
5/32 Alternative Splicing Database (ASD) splice patterns (SP) for STK25 (see all 32) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | - | | - | | | | | | | | | | - | | - | | - | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | - | | - | | | | | | | | | | - | | - | | - | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | - | | - | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | |
| ExUns: | 8c | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | · | 13c | · | 13d | · | 13e | ^ | 14a | · | 14b | · |
|---|
|
| SP1: | - | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | - | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | - | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | - | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | - | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | |
| ExUns: | 14c | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | ^ | 18 |
|---|
|
| SP1: | | | | | - | | - | | - | | | | | | | | |
| SP2: | | | | | - | | - | | - | | | | | | | | |
| SP3: | | | | | - | | - | | - | | | | | | | | |
| SP4: | | | | | - | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for STK25
|
Expression
for STK25 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STK25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGCCATAG
About this image
See STK25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STK25
SOURCE GeneReport for Unigene cluster: Hs.516807
UniProtKB/Swiss-Prot: STK25_HUMAN, O00506Tissue specificity: Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomachfollowed by heart and lung
SABiosciences Expression via Pathway-Focused PCR Array including STK25: | Oxidative Stress in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STK25
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STK25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STK25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STK25 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK25 |
Orthologs
for STK25 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for STK25 gene from 8/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
STK251 |
serine/threonine kinase 25 |
80.2(n)
92.25(a) |
|
378801 NM_204374.1 NP_989705.1 |
lizard
(Anolis carolinensis) |
Reptilia |
STK256 |
-- |
89(a) |
1 ↔ 1 |
3(30415056-30434293) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BX848572.12 |
-- |
80.63(n) |
|
BX848572.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC045867.12 |
-- |
77.75(n) |
|
BC045867.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG51693 |
protein amino acid phosphorylation receptor
signaling more |
80(a) |
|
89E12 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
gck-13 |
serine/threonine kinase |
66(a) |
|
V(8950405-8958008) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATMAP4K ALPHA16AT3G152206 |
putative protein kinase |
29(a)28(a) |
many ↔ manymany ↔ many |
1(19813804-19819564) 3(5126597-5132306) |
rice
(Oryza sativa) |
Liliopsida |
-- |
STE_PAK_Ste20_MST_like.1 - STE kinases include hom... |
29(a) |
1 → many |
7(19257731-19267291) |
ENSEMBL Gene Tree for STK25 (if available)
TreeFam Gene Tree for STK25 (if available) |
Paralogs
for STK25 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STK25 gene
- STK242 STK42 STK32 MST42
18/149 SIMAP similar genes for STK25 using alignment to 15 protein entries: STK25_HUMAN (see all proteins)
(see all similar genes):DKFZp686J1430 STK24 MST4 PAK2 STK3 MINK1
MYO3A PAK1 TNIK STK4 MAP4K3 MAP4K5
TAOK3 PAK3 MYO3B MAP4K1 SLK STK4/SLC36AL fusion
STK25 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for STK25
PGOHUM00000235004
|
Genomic Variants
for STK25 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STK25 (242432089 - 242449145 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for STK25
3 CNVs: 31024 4331 3410 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for STK25 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STK25 for disorders About GeneDecksing
OMIM gene information: 602255
OMIM disorders: --
7  diseases for STK25: About MalaCardscerebral cavernous malformations cavernous malformation cerebral cavernous malformations 3 pseudopseudohypoparathyroidism
brachydactyly anoxia cerebritis
1 disease from the University of Copenhagen DISEASES database for STK25:Pseudopseudohypoparathyroidism Export disorders for STK25 gene to outside databases
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Publications
for STK25 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for STK25 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with STK25) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway. (PubMed id 8887545)1, 2, 3, 9 Pombo C.M.... Force T. (1996)
- YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta. (PubMed id 15037601)1, 2, 3 Preisinger C.... Barr F.A. (2004)
- YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways. (PubMed id 9160885)1, 2, 3 Osada S.... Ohno S. (1997)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations. (PubMed id 17657516)1, 9 Voss K....Felbor U. (2007)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- PDCD10 interacts with STK25 to accelerate cell apoptos is under oxidative stress. (PubMed id 22652780)1 Zhang H....Ma D. (2012)
- Serine/threonine protein kinase 25 (STK25): a novel ne gative regulator of lipid and glucose metabolism in rodent and human skeletal mu scle. (PubMed id 22391949)1 Nerstedt A....Mahlapuu M. (2012)
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External Searches for STK25 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing STK25 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing STK25 gene
(According to HUGE)
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Specialized Databases showing STK25 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for STK25 | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/stk25/ |
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| Patent Information for STK25 gene:
Search GeneIP for patents involving STK25
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for STK25 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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