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Aliases for STK24 Gene

Aliases for STK24 Gene

  • Serine/Threonine Kinase 24 2 3
  • MST3 3 4 6
  • Mammalian STE20-Like Protein Kinase 3 3 4
  • Sterile 20-Like Kinase 3 2 3
  • STE20-Like Kinase MST3 3 4
  • STE20-Like Kinase 3 2 3
  • EC 2.7.11.1 4 63
  • MST3B 3 6
  • STK3 3 4
  • Serine/Threonine Kinase 24 (Ste20, Yeast Homolog) 2
  • Serine/Threonine Kinase 24 (STE20 Homolog, Yeast) 3
  • Epididymis Secretory Protein Li 95 3
  • Serine/Threonine-Protein Kinase 24 3
  • EC 2.7.11 63
  • HEL-S-95 3
  • STE20 3
  • MST-3 4

External Ids for STK24 Gene

Previous GeneCards Identifiers for STK24 Gene

  • GC13M097464
  • GC13M093491
  • GC13M097941
  • GC13M096802
  • GC13M097902
  • GC13M099103
  • GC13M079700

Summaries for STK24 Gene

Entrez Gene Summary for STK24 Gene

  • This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GeneCards Summary for STK24 Gene

STK24 (Serine/Threonine Kinase 24) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Signaling by GPCR. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is STK4.

UniProtKB/Swiss-Prot for STK24 Gene

  • Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on Thr-442 and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.

Gene Wiki entry for STK24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK24 Gene

Genomics for STK24 Gene

Regulatory Elements for STK24 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STK24 Gene

Start:
98,445,185 bp from pter
End:
98,577,940 bp from pter
Size:
132,756 bases
Orientation:
Minus strand

Genomic View for STK24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STK24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK24 Gene

Proteins for STK24 Gene

  • Protein details for STK24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6E0-STK24_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 24
    Protein Accession:
    Q9Y6E0
    Secondary Accessions:
    • O14840
    • Q5JV92

    Protein attributes for STK24 Gene

    Size:
    443 amino acids
    Molecular mass:
    49308 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer. Interacts with CTTNBP2NL.

    Three dimensional structures from OCA and Proteopedia for STK24 Gene

    Alternative splice isoforms for STK24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK24 Gene

Proteomics data for STK24 Gene at MOPED

Post-translational modifications for STK24 Gene

  • Isoform B is activated by phosphorylation by PKA. Oxidative stress induces phosphorylation. Activated by autophosphorylation at Thr-190 and phosphorylation at this site is essential for its function. Manganese, magnesium and cobalt-dependent autophosphorylation is mainly on threonine residues while zinc-dependent autophosphorylation is on both serine and threonine residues.
  • Proteolytically processed by caspases during apoptosis. Proteolytic cleavage results in kinase activation, nuclear translocation of the truncated form (MST3/N) and the induction of apoptosis.
  • Ubiquitination at Lys187, Lys238, and Lys292
  • Modification sites at PhosphoSitePlus

Other Protein References for STK24 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STK24 (MST3)

Domains for STK24 Gene

Gene Families for STK24 Gene

Protein Domains for STK24 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6E0

UniProtKB/Swiss-Prot:

STK24_HUMAN :
  • Q9Y6E0
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STK24: view

Function for STK24 Gene

Molecular function for STK24 Gene

GENATLAS Biochemistry: serine/threonine kinase 24,Ste20 yeast homolog
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=12.8 uM for manganese ions {ECO:0000269 PubMed:15917084}; KM=34.9 uM for cobalt ions {ECO:0000269 PubMed:15917084}; KM=22.7 uM for magnesium ions {ECO:0000269 PubMed:15917084}; KM=4.1 uM for zinc ions {ECO:0000269 PubMed:15917084}; Vmax=2623.1 pmol/min/mg enzyme for manganese ions {ECO:0000269 PubMed:15917084}; Vmax=1746.1 pmol/min/mg enzyme for cobalt ions {ECO:0000269 PubMed:15917084}; Vmax=129.1 pmol/min/mg enzyme for magnesium ions {ECO:0000269 PubMed:15917084}; Vmax=22.3 pmol/min/mg enzyme for zinc ions {ECO:0000269 PubMed:15917084};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on Thr-442 and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.

Enzyme Numbers (IUBMB) for STK24 Gene

Gene Ontology (GO) - Molecular Function for STK24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 9353338
GO:0004674 protein serine/threonine kinase activity IDA 16314523
GO:0004702 receptor signaling protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with STK24: view
genes like me logo Genes that share phenotypes with STK24: view

Animal Model Products

CRISPR Products

miRNA for STK24 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STK24

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for STK24 Gene

Localization for STK24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK24 Gene

Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK24 Gene COMPARTMENTS Subcellular localization image for STK24 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for STK24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12107159
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STK24: view

Pathways for STK24 Gene

genes like me logo Genes that share pathways with STK24: view

Pathways by source for STK24 Gene

1 Qiagen pathway for STK24 Gene
2 Cell Signaling Technology pathways for STK24 Gene
1 BioSystems pathway for STK24 Gene

Gene Ontology (GO) - Biological Process for STK24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 19604147
GO:0006915 apoptotic process TAS --
GO:0006921 cellular component disassembly involved in execution phase of apoptosis TAS --
GO:0007165 signal transduction TAS 9353338
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IMP 19604147
genes like me logo Genes that share ontologies with STK24: view

Compounds for STK24 Gene

(3) HMDB Compounds for STK24 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Manganese
  • manganese
7439-96-5

(1) Novoseek inferred chemical compound relationships for STK24 Gene

Compound -log(P) Hits PubMed IDs
threonine 45.9 5
genes like me logo Genes that share compounds with STK24: view

Transcripts for STK24 Gene

Unigene Clusters for STK24 Gene

Serine/threonine kinase 24:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STK24

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK24 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - - - - - -
SP2: - - -
SP3:
SP4: - -
SP5: - - - - - - -
SP6: -
SP7: -
SP8:

Relevant External Links for STK24 Gene

GeneLoc Exon Structure for
STK24
ECgene alternative splicing isoforms for
STK24

Expression for STK24 Gene

mRNA expression in normal human tissues for STK24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for STK24 Gene

SOURCE GeneReport for Unigene cluster for STK24 Gene Hs.508514

mRNA Expression by UniProt/SwissProt for STK24 Gene

Q9Y6E0-STK24_HUMAN
Tissue specificity: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex
genes like me logo Genes that share expressions with STK24: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for STK24 Gene

Orthologs for STK24 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK24 35
  • 97.45 (n)
  • 97.91 (a)
STK24 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STK24 35
  • 88.55 (n)
  • 96.98 (a)
STK24 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK24 35
  • 90.4 (n)
  • 96.9 (a)
STK24 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk24 35
  • 88.17 (n)
  • 97.68 (a)
Stk24 16
Stk24 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK24 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK24 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk24 35
  • 87.08 (n)
  • 96.75 (a)
chicken
(Gallus gallus)
Aves STK24 35
  • 78.18 (n)
  • 90.09 (a)
STK24 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK24 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3008 35
tropical clawed frog
(Silurana tropicalis)
Amphibia stk24 35
  • 77.2 (n)
  • 87.97 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2079 35
zebrafish
(Danio rerio)
Actinopterygii stk24a 36
  • 75 (a)
OneToMany
stk24b 35
  • 73.12 (n)
  • 84.26 (a)
stk24b 36
  • 82 (a)
OneToMany
wufi29b08 35
fruit fly
(Drosophila melanogaster)
Insecta GckIII 36
  • 41 (a)
OneToMany
CG5169 37
  • 73 (a)
worm
(Caenorhabditis elegans)
Secernentea gck-1 36
  • 31 (a)
OneToMany
gck-1 37
  • 76 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIC1 38
SPS1 36
  • 31 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.17164 35
rice
(Oryza sativa)
Liliopsida Os.18593 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04096 35
  • 58.73 (n)
  • 60.82 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sid1 35
  • 52.46 (n)
  • 47.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4671 36
  • 65 (a)
OneToMany
Species with no ortholog for STK24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK24 Gene

ENSEMBL:
Gene Tree for STK24 (if available)
TreeFam:
Gene Tree for STK24 (if available)

Paralogs for STK24 Gene

Paralogs for STK24 Gene

Pseudogenes.org Pseudogenes for STK24 Gene

genes like me logo Genes that share paralogs with STK24: view

Variants for STK24 Gene

Sequence variations from dbSNP and Humsavar for STK24 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs6956 -- 98,452,435(-) CACCT(A/G)GAGGT utr-variant-3-prime
rs8481 -- 98,453,141(-) TTTTC(C/T)TTTTT utr-variant-3-prime
rs12463 -- 98,453,048(-) CCCAG(C/T)GCCAG utr-variant-3-prime
rs745638 -- 98,467,053(-) AAACA(C/G)GGCTC intron-variant
rs745639 -- 98,467,025(-) TCTAA(C/T)GTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK24 Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER Inversion 18451855
nsv471172 CNV Gain 18288195
nsv456088 CNV Gain 19166990
nsv832695 CNV Loss 17160897
nsv509511 CNV Insertion 20534489
nsv517409 CNV Gain+Loss 19592680
nsv1141 CNV Insertion 18451855
nsv513394 CNV Insertion 21212237
esv1791098 CNV Insertion 17803354
nsv456089 CNV Loss 19166990
nsv1142 CNV Insertion 18451855
esv2747857 CNV Deletion 23290073
esv2747858 CNV Deletion 23290073
esv26178 CNV Loss 19812545

Relevant External Links for STK24 Gene

HapMap Linkage Disequilibrium report
STK24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK24 Gene

Disorders for STK24 Gene

Relevant External Links for STK24

Genetic Association Database (GAD)
STK24
Human Genome Epidemiology (HuGE) Navigator
STK24
genes like me logo Genes that share disorders with STK24: view

No data available for UniProtKB/Swiss-Prot for STK24 Gene

Publications for STK24 Gene

  1. Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. (PMID: 9353338) Schinkmann K. … Blenis J. (J. Biol. Chem. 1997) 2 3 4 23
  2. Identification of a human brain-specific isoform of mammalian STE20- like kinase 3 that is regulated by cAMP-dependent protein kinase. (PMID: 10644707) Zhou T.-H. … Pei G. (J. Biol. Chem. 2000) 2 3 4 23
  3. Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). (PMID: 12107159) Huang C.Y. … Yuan C.J. (J. Biol. Chem. 2002) 3 4 23
  4. Identification and characterization of the nuclear import and export signals of the mammalian Ste20-like protein kinase 3. (PMID: 15304321) Lee W.S. … Yuan C.J. (FEBS Lett. 2004) 3 4 23
  5. Zinc ion acts as a cofactor for serine/threonine kinase MST3 and has a distinct role in autophosphorylation of MST3. (PMID: 15917084) Lu T.J. … Lai M.D. (J. Inorg. Biochem. 2005) 3 4 23

Products for STK24 Gene

  • Addgene plasmids for STK24

Sources for STK24 Gene

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