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Aliases for STK24 Gene

Aliases for STK24 Gene

  • Serine/Threonine Kinase 24 2 3 5
  • Mammalian STE20-Like Protein Kinase 3 3 4
  • Sterile 20-Like Kinase 3 2 3
  • STE20-Like Kinase MST3 3 4
  • STE20-Like Kinase 3 2 3
  • EC 2.7.11.1 4 63
  • MST3 3 4
  • STK3 3 4
  • Serine/Threonine Kinase 24 (Ste20, Yeast Homolog) 2
  • Serine/Threonine Kinase 24 (STE20 Homolog, Yeast) 3
  • Epididymis Secretory Protein Li 95 3
  • EC 2.7.11 63
  • HEL-S-95 3
  • MST3B 3
  • STE20 3
  • MST-3 4

External Ids for STK24 Gene

Previous GeneCards Identifiers for STK24 Gene

  • GC13M097464
  • GC13M093491
  • GC13M097941
  • GC13M096802
  • GC13M097902
  • GC13M099103
  • GC13M079700

Summaries for STK24 Gene

Entrez Gene Summary for STK24 Gene

  • This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GeneCards Summary for STK24 Gene

STK24 (Serine/Threonine Kinase 24) is a Protein Coding gene. Among its related pathways are Apoptotic cleavage of cellular proteins and Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK4.

UniProtKB/Swiss-Prot for STK24 Gene

  • Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on Thr-442 and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.

Gene Wiki entry for STK24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK24 Gene

Genomics for STK24 Gene

Regulatory Elements for STK24 Gene

Enhancers for STK24 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STK24 on UCSC Golden Path with GeneCards custom track

Promoters for STK24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STK24 on UCSC Golden Path with GeneCards custom track

Genomic Location for STK24 Gene

Chromosome:
13
Start:
98,445,185 bp from pter
End:
98,577,940 bp from pter
Size:
132,756 bases
Orientation:
Minus strand

Genomic View for STK24 Gene

Genes around STK24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK24 Gene

Proteins for STK24 Gene

  • Protein details for STK24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6E0-STK24_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 24
    Protein Accession:
    Q9Y6E0
    Secondary Accessions:
    • O14840
    • Q5JV92

    Protein attributes for STK24 Gene

    Size:
    443 amino acids
    Molecular mass:
    49308 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer. Interacts with CTTNBP2NL.

    Three dimensional structures from OCA and Proteopedia for STK24 Gene

    Alternative splice isoforms for STK24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK24 Gene

Proteomics data for STK24 Gene at MOPED

Post-translational modifications for STK24 Gene

  • Isoform B is activated by phosphorylation by PKA. Oxidative stress induces phosphorylation. Activated by autophosphorylation at Thr-190 and phosphorylation at this site is essential for its function. Manganese, magnesium and cobalt-dependent autophosphorylation is mainly on threonine residues while zinc-dependent autophosphorylation is on both serine and threonine residues.
  • Proteolytically processed by caspases during apoptosis. Proteolytic cleavage results in kinase activation, nuclear translocation of the truncated form (MST3/N) and the induction of apoptosis.
  • Ubiquitination at Lys 238
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STK24 (MST3)
  • Abcam antibodies for MST3

Domains & Families for STK24 Gene

Gene Families for STK24 Gene

Protein Domains for STK24 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6E0

UniProtKB/Swiss-Prot:

STK24_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STK24: view

Function for STK24 Gene

Molecular function for STK24 Gene

GENATLAS Biochemistry:
serine/threonine kinase 24,Ste20 yeast homolog
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=12.8 uM for manganese ions {ECO:0000269 PubMed:15917084}; KM=34.9 uM for cobalt ions {ECO:0000269 PubMed:15917084}; KM=22.7 uM for magnesium ions {ECO:0000269 PubMed:15917084}; KM=4.1 uM for zinc ions {ECO:0000269 PubMed:15917084}; Vmax=2623.1 pmol/min/mg enzyme for manganese ions {ECO:0000269 PubMed:15917084}; Vmax=1746.1 pmol/min/mg enzyme for cobalt ions {ECO:0000269 PubMed:15917084}; Vmax=129.1 pmol/min/mg enzyme for magnesium ions {ECO:0000269 PubMed:15917084}; Vmax=22.3 pmol/min/mg enzyme for zinc ions {ECO:0000269 PubMed:15917084};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on Thr-442 and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.

Enzyme Numbers (IUBMB) for STK24 Gene

Gene Ontology (GO) - Molecular Function for STK24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048365 Rac GTPase binding IBA --
genes like me logo Genes that share ontologies with STK24: view
genes like me logo Genes that share phenotypes with STK24: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK24 Gene

Localization for STK24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK24 Gene

Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK24 Gene COMPARTMENTS Subcellular localization image for STK24 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 2
plasma membrane 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for STK24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with STK24: view

Pathways & Interactions for STK24 Gene

genes like me logo Genes that share pathways with STK24: view

Pathways by source for STK24 Gene

2 Cell Signaling Technology pathways for STK24 Gene
1 Qiagen pathway for STK24 Gene

SIGNOR curated interactions for STK24 Gene

Activates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for STK24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 19604147
GO:0006915 apoptotic process TAS --
GO:0007165 signal transduction TAS 9353338
GO:0007266 Rho protein signal transduction IBA --
GO:0007346 regulation of mitotic cell cycle IBA --
genes like me logo Genes that share ontologies with STK24: view

Drugs & Compounds for STK24 Gene

(3) Drugs for STK24 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Manganese Pharma 32

(1) Additional Compounds for STK24 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK24: view

Transcripts for STK24 Gene

Unigene Clusters for STK24 Gene

Serine/threonine kinase 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK24 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - - - - - -
SP2: - - -
SP3:
SP4: - -
SP5: - - - - - - -
SP6: -
SP7: -
SP8:

Relevant External Links for STK24 Gene

GeneLoc Exon Structure for
STK24
ECgene alternative splicing isoforms for
STK24

Expression for STK24 Gene

mRNA expression in normal human tissues for STK24 Gene

Protein differential expression in normal tissues from HIPED for STK24 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STK24 Gene



SOURCE GeneReport for Unigene cluster for STK24 Gene Hs.508514

mRNA Expression by UniProt/SwissProt for STK24 Gene

Q9Y6E0-STK24_HUMAN
Tissue specificity: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.
genes like me logo Genes that share expression patterns with STK24: view

Protein tissue co-expression partners for STK24 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for STK24 Gene

Orthologs for STK24 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK24 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STK24 35
  • 88.55 (n)
  • 96.98 (a)
STK24 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK24 35
  • 90.4 (n)
  • 96.9 (a)
STK24 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk24 35
  • 88.17 (n)
  • 97.68 (a)
Stk24 16
Stk24 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STK24 35
  • 97.45 (n)
  • 97.91 (a)
STK24 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk24 35
  • 87.08 (n)
  • 96.75 (a)
oppossum
(Monodelphis domestica)
Mammalia STK24 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK24 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK24 35
  • 78.18 (n)
  • 90.09 (a)
STK24 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK24 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk24 35
  • 77.2 (n)
  • 87.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3008 35
zebrafish
(Danio rerio)
Actinopterygii stk24b 35
  • 73.12 (n)
  • 84.26 (a)
wufi29b08 35
stk24a 36
  • 75 (a)
OneToMany
stk24b 36
  • 82 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2079 35
fruit fly
(Drosophila melanogaster)
Insecta CG5169 37
  • 73 (a)
GckIII 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gck-1 37
  • 76 (a)
gck-1 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPS1 36
  • 31 (a)
OneToMany
KIC1 38
rice
(Oryza sativa)
Liliopsida Os.18593 35
corn
(Zea mays)
Liliopsida Zm.17164 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04096 35
  • 58.73 (n)
  • 60.82 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sid1 35
  • 52.46 (n)
  • 47.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4671 36
  • 65 (a)
OneToMany
Species with no ortholog for STK24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK24 Gene

ENSEMBL:
Gene Tree for STK24 (if available)
TreeFam:
Gene Tree for STK24 (if available)

Paralogs for STK24 Gene

Paralogs for STK24 Gene

Pseudogenes.org Pseudogenes for STK24 Gene

genes like me logo Genes that share paralogs with STK24: view

Variants for STK24 Gene

Sequence variations from dbSNP and Humsavar for STK24 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs55953606 - 98,457,222(+) GGCAC(A/G)CCTCC reference, missense
rs55897869 - 98,457,187(+) CACGA(G/T)CTGGG reference, missense
rs6956 -- 98,452,435(-) CACCT(A/G)GAGGT utr-variant-3-prime
rs8481 -- 98,453,141(-) TTTTC(C/T)TTTTT utr-variant-3-prime
rs12463 -- 98,453,048(-) CCCAG(C/T)GCCAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for STK24 Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER Inversion 18451855
nsv471172 CNV Gain 18288195
nsv456088 CNV Gain 19166990
nsv832695 CNV Loss 17160897
nsv509511 CNV Insertion 20534489
nsv517409 CNV Gain+Loss 19592680
nsv1141 CNV Insertion 18451855
nsv513394 CNV Insertion 21212237
esv1791098 CNV Insertion 17803354
nsv456089 CNV Loss 19166990
nsv1142 CNV Insertion 18451855
esv2747857 CNV Deletion 23290073
esv2747858 CNV Deletion 23290073
esv26178 CNV Loss 19812545

Variation tolerance for STK24 Gene

Residual Variation Intolerance Score: 13.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STK24 Gene

Disorders for STK24 Gene

Relevant External Links for STK24

Genetic Association Database (GAD)
STK24
Human Genome Epidemiology (HuGE) Navigator
STK24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK24

No disorders were found for STK24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK24 Gene

Publications for STK24 Gene

  1. Identification of a human brain-specific isoform of mammalian STE20- like kinase 3 that is regulated by cAMP-dependent protein kinase. (PMID: 10644707) Zhou T.-H. … Pei G. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. (PMID: 9353338) Schinkmann K. … Blenis J. (J. Biol. Chem. 1997) 2 3 23
  3. Mammalian Ste20-like protein kinase 3 induces a caspase-independent apoptotic pathway. (PMID: 19782762) Lin C.Y. … Yuan C.J. (Int. J. Biochem. Cell Biol. 2010) 3 23
  4. Mammalian sterile 20-like kinase 3 (MST3) mediates oxidative-stress- induced cell death by modulating JNK activation. (PMID: 19604147) Chen C.B. … Porter A.G. (Biosci. Rep. 2009) 3 23
  5. Mammalian Ste20-like protein kinase 3 mediates trophoblast apoptosis in spontaneous delivery. (PMID: 18040775) Wu H.Y. … Yuan C.J. (Apoptosis 2008) 3 23

Products for STK24 Gene

Sources for STK24 Gene

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