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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STK24 Gene

protein-coding   GIFtS: 64
GCID: GC13M099103

serine/threonine kinase 24

(Previous names: serine/threonine kinase 24 (Ste20, yeast homolog) )
 Explore 10 diseases affiliated with
STK24 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STK24    

Aliases
for STK24 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Serine/Threonine Kinase 241 2     EC 2.7.11.13 8
MST31 2 3 5     Serine/Threonine Kinase 24 (Ste20, Yeast Homolog)1
STK31 2 3     Serine/Threonine Kinase 24 (STE20 Homolog, Yeast)2
MST3B1 2 5     Serine/Threonine-Protein Kinase 242
STE201 2     STE20-Like Kinase 32
MST-31 3     Sterile 20-Like Kinase 32
Mammalian STE20-Like Protein Kinase 32 3     EC 2.7.118
STE20-Like Kinase MST32 3     

External Ids:    HGNC: 114031   Entrez Gene: 84282   Ensembl: ENSG000001025727   OMIM: 6049845   UniProtKB: Q9Y6E03   

Export aliases for STK24 gene to outside databases

Previous GC identifers: GC13M097464 GC13M093491 GC13M097941 GC13M096802 GC13M097902 GC13M079700


Summaries
for STK24 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for STK24:
The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In
mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation.
Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory
domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM
603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain
without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000 (PubMed
10644707)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: STK24_HUMAN, Q9Y6E0
Function: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in
response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating
phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays
a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of
AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its
kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation:
phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key
regulator of axon regeneration in the optic nerve and radial nerve

Gene Wiki entry for STK24


Genomic Views
for STK24 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_009952.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STK24 gene promoter:
         AhR   Pbx1a   HSF1 (long)   Roaz   Arnt   FOXJ2 (long isoform)   HSF1short   FOXO1a   FOXJ2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STK24 promoter sequence
   Search SABiosciences Chromatin IP Primers for STK24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31.2-q32.3   Ensembl cytogenetic band:  13q32.2   HGNC cytogenetic band: 13q31.2-q32.3

STK24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK24 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M099103:  view genomic region     (about GC identifiers)

Start:
 99,102,455 bp from pter      End:
 99,230,194 bp from pter
Size:
 127,740 bases      Orientation:
 minus strand

Proteins
for STK24 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STK24_HUMAN, Q9Y6E0 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 24  
Size: 443 amino acids; 49308 Da
Cofactor: Magnesium, manganese, cobalt and zinc
Subunit: Monomer
Subcellular location: Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus.
Co-localizes with STK38L in the membrane
6/8 PDB 3D structures from and Proteopedia for STK24 (see all 8):
3A7F (3D)        3A7G (3D)        3A7H (3D)        3A7I (3D)        3A7J (3D)        3CKW (3D)    
Secondary accessions: O14840 Q5JV92
Alternative splicing: 2 isoforms:  Q9Y6E0-1   Q9Y6E0-2   (Contains a phosphoserine at position 4. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2)

Explore the universe of human proteins at neXtProt for STK24: NX_Q9Y6E0

Post-translational modifications:

  • Proteolytically processed by caspases during apoptosis. Proteolytic cleavage results in kinase activation, nuclear
    • translocation of the truncated form (MST3/N) and the induction of apoptosis1
  • Isoform B is activated by phosphorylation by PKA. Oxidative stress induces phosphorylation. Activated by
    • autophosphorylation at Thr-190 and phosphorylation at this site is essential for its function. Manganese, magnesium
    and cobalt-dependent autophosphorylation is mainly on threonine residues while zinc-dependent autophosphorylation is
    on both serine and threonine residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y6E0

    • 4/14 DME Specific Peptides for STK24 (Q9Y6E0) (see all 14)
     LLKHKFI  GITAIEL  LDYLHSE  WMAPEVI 

    STK24 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001027467.2  NP_003567.2  

    ENSEMBL proteins: 
     ENSP00000380651   ENSP00000365737   ENSP00000365730   ENSP00000402810   ENSP00000402764  
     ENSP00000442539  
    Reactome Protein details: Q9Y6E0
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant STK24 Protein
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    Novus Biologicals STK24 Proteins
    Novus Biologicals STK24 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for STK24

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12107159
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA12107159
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--


    STK24 for ontologies           About GeneDecksing



    STK24 Antibody Products: 
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    Uscn ELISAs and CLIAs for STK24

    Protein Domains /
    Families
    for STK24 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STK24 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y6E0

    ProtoNet protein and cluster: Q9Y6E0

    UniProtKB/Swiss-Prot: STK24_HUMAN, Q9Y6E0
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for STK24 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STK24_HUMAN, Q9Y6E0
    Function: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in
    response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating
    phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays
    a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of
    AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its
    kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation:
    phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key
    regulator of axon regeneration in the optic nerve and radial nerve
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Biophysicochemical properties: Kinetic parameters: KM=12.8 uM for manganese ions; KM=34.9 uM for cobalt ions; KM=22.7
    uM for magnesium ions; KM=4.1 uM for zinc ions; Vmax=2623.1 pmol/min/mg enzyme for manganese ions; Vmax=1746.1
    pmol/min/mg enzyme for cobalt ions; Vmax=129.1 pmol/min/mg enzyme for magnesium ions; Vmax=22.3 pmol/min/mg enzyme for
    zinc ions;

         Genatlas biochemistry entry for STK24:
    serine/threonine kinase 24,Ste20 yeast homolog

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
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    hsa-mir-141 (MIRT001813)

    OriGene 3'-UTR Clone (see all 2): STK24
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STK24
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate STK24 (see all 80):
    hsa-miR-300 hsa-miR-128 hsa-miR-502-3p hsa-miR-877* hsa-miR-508-5p hsa-miR-3148 hsa-miR-455-5p hsa-miR-186*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: STK24
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STK24

    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for STK24

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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9353338
    GO:0004674protein serine/threonine kinase activity IDA17046825
    GO:0005515protein binding IPI18782753
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----


    STK24 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for STK24:
     Decreased Hepatitis C virus re  Decreased viability of wild-ty  Upregulation of Wnt/beta-caten 

    Animal Models:
         1 MGI phenotypic allele for Stk24 (no phenotypes)

    STK24 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for STK24 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic cleavage of cellular proteins
    		Apoptotic cleavage of cellular proteins1.00
    		Apoptotic execution phase0.73
    2Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00
    3Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    4Sweet Taste Signaling
    		Sperm Motility0.36
    5Ubiquitinated Orc1 is degraded by the proteasome
    		Apoptosis0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for STK24
        Sperm Motility

    2 Cell Signaling Technology (CST) Pathways for STK24
        Apoptosis and Autophagy
    Cytoskeletal Signaling

    3        Reactome Pathways for STK24
        Apoptotic execution phase
    Apoptotic cleavage of cellular proteins
    Apoptosis



    STK24 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STK24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/566 Interacting proteins for STK24 (Q9Y6E01, 2, 3 ENSP000003657304) via UniProtKB, MINT, STRING, and/or I2D (see all 566)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCT3P493682, 3, ENSP000003572444MINT-7947479 I2D: score=2 STRING: ENSP00000357244
    CCT4P509912, 3, ENSP000003779584MINT-7947479 I2D: score=2 STRING: ENSP00000377958
    CCT7Q998322, 3, ENSP000002580914MINT-7947479 I2D: score=2 STRING: ENSP00000258091
    CTTNBP2NLQ9P2B41, 3, ENSP000002712774EBI-1054809,EBI-1774273 I2D: score=2 STRING: ENSP00000271277
    DDX5P178442, 3, ENSP000002257924MINT-7947479 I2D: score=2 STRING: ENSP00000225792
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA19604147
    GO:0006915apoptotic process TAS--
    GO:0006917induction of apoptosis IMP12107159
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0007165signal transduction TAS9353338


    STK24 for ontologies           About GeneDecksing



    Drugs & Compounds
    for STK24 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STK24 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STK24

    3 HMDB Compounds for STK24    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Manganesemanganese 7439-96-5--
    1 Novoseek chemical compound relationship for STK24 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 45.9 9 15917084 (3), 19782762 (1), 9353338 (1)

    Search CenterWatch for drugs/clinical trials and news about STK24 

    Transcripts
    for STK24 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STK24 gene (2 alternative transcripts): 
    NM_001032296.2  NM_003576.3  

    Unigene Cluster for STK24:

    Serine/threonine kinase 24
    Hs.508514  [show with all ESTs]
    Unigene Representative Sequence: NM_001032296
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397517(uc001vnm.1 uc001vnn.1 uc010tim.1) ENST00000376554
    ENST00000376547 ENST00000418038 ENST00000444574 ENST00000491878 ENST00000481288
    ENST00000539966

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STK24
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate STK24 (see all 80):
    hsa-miR-300 hsa-miR-128 hsa-miR-502-3p hsa-miR-877* hsa-miR-508-5p hsa-miR-3148 hsa-miR-455-5p hsa-miR-186*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STK24 (see all 7)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STK24
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF024636.1 AF083420.1 AF339785.1 AF339826.1 AK297583.1 AK299140.1 BC035578.1 BC065378.1 
    BT019619.1 CR542227.1 

    17 DOTS entries:

    DT.448566  DT.40120476  DT.100811362  DT.97855737  DT.100811363  DT.100811371  DT.120778127  DT.120778162 
    DT.100775992  DT.100811356  DT.120778106  DT.120778164  DT.120778188  DT.95214949  DT.97823882  DT.100638696 
    DT.100782044 

    24/417 AceView cDNA sequences (see all 417):

    AA281058 BU620405 BM830630 AI569999 AA381235 AI281391 AA586774 AI858669 
    BM968437 BI868225 CA442517 CR615038 AA298486 BG253936 AI378161 BM741777 
    AW239508 AA007238 AA251771 BM768340 H11514 BQ943915 AI658998 AA864820 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for STK24 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                    -     -     -           -     -                                               -                                         -         
    SP2:                                            -     -                                               -                                                   
    SP3:                                                                                                                                                      
    SP4:                                            -     -                                                                                                   
    SP5:                    -     -     -           -     -           -     -                                                                                 


    ECgene alternative splicing isoforms for STK24

    Expression
    for STK24 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STK24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGCGCTCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See STK24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STK24

    SOURCE GeneReport for Unigene cluster: Hs.508514

    UniProtKB/Swiss-Prot: STK24_HUMAN, Q9Y6E0
    Tissue specificity: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and
    cerebral cortex

        SABiosciences Custom PCR Arrays for STK24
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    Orthologs
    for STK24 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STK24 gene from 8/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves STK241 serine/threonine kinase 24 78.18(n)
    90.09(a)    		   418780  NM_001030817.1  NP_001025988.1 
    lizard
    (Anolis carolinensis)    		 Reptilia STK246
    		 --
    		 91(a)
    		 1 ↔ 1
    		 3(98459893-98480944)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.30082 Xenopus laevis transcribed sequence with strong similarity more 81.75(n)    BX843050.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi29b082 Danio rerio cDNA clone MGC66137 IMAGE3817670, complete more 82.32(n)    BC054651.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG51693 protein amino acid phosphorylation receptor
    signaling more    		 73(a)   89E12   --
    worm
    (Caenorhabditis elegans)    		 Secernentea gck-13 serine/threonine kinase 76(a)   V(8950405-8958008)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATMAP4K ALPHA11 map 4 kinase alpha1 61.05(n)
    62.2(a)    		   841750  NM_001084239.1  NP_001077708.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.185932 Oryza sativa (japonica cultivar-group) cDNA clone0 more 76.88(n)    AK102538.1 


    ENSEMBL Gene Tree for STK24 (if available)
    TreeFam Gene Tree for STK24 (if available) 

    Paralogs
    for STK24 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STK24 gene
    STK42  STK32  STK252  MST42  
    18/52 SIMAP similar genes for STK24 using alignment to 9 protein entries:     STK24_HUMAN (see all proteins) (see all similar genes):
    STK25    DKFZp686J1430    MST4    STK3    MAP4K5    PAK2
    TAOK3    TAOK2    MAP4K3    PAK3    TAOK1    PAK1
    TNIK    MYO3A    MAP4K1    SLK    MAP4K4    STK4

    STK24 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STK24
    PGOHUM00000241570


    Genomic Variants
    for STK24 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2546 NCBI SNPs in STK24 are shown (see all 2546)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs79988081,2
    		C,--99102055(+) CTGTGA/TGGGGG 3 -- ds50010--------
    rs583422681,2
    		C,--99102056(+) TGTGT-/GGGGGG 3 -- ds50010--------
    rs2022263021,2
    		C--99102063(+) GGGGGA/GAGGGG 3 -- ds50010--------
    rs1854826221,2
    		--99102095(+) GGTTTC/TTAAAG 3 -- ds50010--------
    rs790432491,2
    		F,--99102100(+) CTAAAG/ACCCCA 3 -- ds50011Minor allele frequency- A:0.08WA 118
    rs790893871,2
    		F,--99102101(+) TAAAGC/ACCCAG 3 -- ds50011Minor allele frequency- A:0.09WA 118
    rs673995311,2
    		C,--99102280(+) TCAGC-/TATT  
                TATTT     		3 -- ds50010--------
    rs37421371,2
    		C,F,H,--99102449(-) TATCTG/ACATCA 3 -- ds500123Minor allele frequency- A:0.18EA NS NA WA 4184
    rs38328851,2
    		C,--99102478(-) CAGGG-/GCCAAT 3 -- ut31 ds50010--------
    rs412791221,2
    		C,--99102564(+) ATACAC/GAAGCT 2 -- ut312Minor allele frequency- G:0.11WA 120

    HapMap Linkage Disequilibrium report for STK24 (99102455 - 99230194 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for STK24
         1 CNV: 66527

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    Disorders / Diseases
    for STK24 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STK24 for disorders           About GeneDecksing

    OMIM gene information: 604984    OMIM disorders: --

    10 diseases for STK24:    About MalaCards
    cerebral cavernous malformations    cavernous malformation    cerebral cavernous malformations 3    pseudohypoaldosteronism
    bipolar disorder    cerebritis    hypoxia    schizophrenia
    pancreatic cancer    pancreatitis

    Human Genome Epidemiology (HuGE) Navigator: STK24 (3 documents)

    Export disorders for STK24 gene to outside databases

    Publications
    for STK24 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STK24 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with STK24)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human brain-specific isoform of mammalian STE20- like kinase 3 that is regulated by cAMP-dependent protein kinase. (PubMed id 10644707)1, 2, 3, 9 Zhou T.-H....Pei G. (2000)
    2. Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. (PubMed id 9353338)1, 2, 3, 9 Schinkmann K. and Blenis J. (1997)
    3. Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis. (PubMed id 12107159)1, 2, 9 Huang C.Y....Yuan C.J. (2002)
    4. Mammalian sterile 20-like kinase 3 (MST3) mediates ox idative-stress-induced cell death by modulating JNK activation. (PubMed id 19604147)1, 2, 9 Chen C.B....Porter A.G. (2009)
    5. Mammalian Ste20-like protein kinase 3 induces a caspa se-independent apoptotic pathway. (PubMed id 19782762)1, 2, 9 Lin C.Y....Yuan C.J. (2010)
    6. Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3. (PubMed id 16314523)1, 2, 9 Stegert M.R....Hemmings B.A. (2005)
    7. Identification and characterization of the nuclear import and export signals of the mammalian Ste20-like protein kinase 3. (PubMed id 15304321)1, 2, 9 Lee W.S....Yuan C.J. (2004)
    8. Structures of human MST3 kinase in complex with adeni ne, ADP and Mn2+. (PubMed id 20124694)1, 2 Ko T.P....Wang A.H. (2010)
    9. Mst3b, an Ste20-like kinase, regulates axon regenerat ion in mature CNS and PNS pathways. (PubMed id 19855390)1, 2 Lorber B....Irwin N. (2009)
    10. Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST. (PubMed id 17046825)1, 2 Lu T.J....Lai M.D. (2006)

    External Searches for STK24 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing STK24 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8428 HGNC: 11403 AceView: STK24 Ensembl:ENSG00000102572 euGenes: HUgn8428
    ECgene: STK24 H-InvDB: STK24

    Other Databases showing STK24 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STK24 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STK24 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for STK24 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STK24 gene:
    Search GeneIP for patents involving STK24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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