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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STK24 Gene

protein-coding   GIFtS: 67
GCID: GC13M099103

Serine/Threonine Kinase 24

(Previous names: serine/threonine kinase 24 (Ste20, yeast homolog))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine/Threonine Kinase 241 2     MST3B2 5
MST32 3 5     Serine/Threonine Kinase 24 (Ste20, Yeast Homolog)1
STE20-Like Kinase 31 2     STE202
Sterile 20-Like Kinase 31 2     Serine/Threonine Kinase 24 (STE20 Homolog, Yeast)2
Mammalian STE20-Like Protein Kinase 32 3     Serine/Threonine-Protein Kinase 242
STK32 3     MST-33
STE20-Like Kinase MST32 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    HGNC: 114031   Entrez Gene: 84282   Ensembl: ENSG000001025727   OMIM: 6049845   UniProtKB: Q9Y6E03   

Export aliases for STK24 gene to outside databases

Previous GC identifers: GC13M097464 GC13M093491 GC13M097941 GC13M096802 GC13M097902 GC13M079700


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STK24 Gene:
The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In
mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and
regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an
N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK
subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a
C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like
kinases (Zhou et al., 2000 (PubMed 10644707)).(supplied by OMIM, Mar 2008)

GeneCards Summary for STK24 Gene: 
STK24 (serine/threonine kinase 24) is a protein-coding gene. Diseases associated with STK24 include pseudohypoaldosteronism, and cerebral cavernous malformations 3, and among its related super-pathways are Apoptotic execution phase and Regulation of Apoptosis. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is STK4.

UniProtKB/Swiss-Prot: STK24_HUMAN, Q9Y6E0
Function: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis
in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating
phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress.
Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear
translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442'
and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN
phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through
PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve

Gene Wiki entry for STK24 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_009952.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STK24 gene promoter:
         AhR   Pbx1a   HSF1 (long)   Roaz   Arnt   FOXJ2 (long isoform)   HSF1short   FOXO1a   FOXJ2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK24 promoter sequence
   Search SABiosciences Chromatin IP Primers for STK24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31.2-q32.3   Ensembl cytogenetic band:  13q32.2   HGNC cytogenetic band: 13q31.2-q32.3

STK24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK24 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M099103:  view genomic region     (about GC identifiers)

Start:
99,102,455 bp from pter      End:
99,230,194 bp from pter
Size:
127,740 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STK24_HUMAN, Q9Y6E0 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 24  
Size: 443 amino acids; 49308 Da
Cofactor: Mg(2+) or Mn(2+) or Co(2+) or Zn(2+)
Subunit: Monomer. Interacts with CTTNBP2NL
Subcellular location: Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus.
Co-localizes with STK38L in the membrane
6/8 PDB 3D structures from and Proteopedia for STK24 (see all 8):
3A7F (3D)        3A7G (3D)        3A7H (3D)        3A7I (3D)        3A7J (3D)        3CKW (3D)    
Secondary accessions: O14840 Q5JV92
Alternative splicing: 2 isoforms:  Q9Y6E0-1   Q9Y6E0-2   (Initiator Met-1 is removed. Contains a phosphoserine at position 4. Contains a N-acetylalanine at position 2)

Explore the universe of human proteins at neXtProt for STK24: NX_Q9Y6E0

Explore proteomics data for STK24 at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytically processed by caspases during apoptosis. Proteolytic cleavage results in kinase activation, nuclear
    translocation of the truncated form (MST3/N) and the induction of apoptosis
  • UniProtKB: Isoform B is activated by phosphorylation by PKA. Oxidative stress induces phosphorylation. Activated by
    autophosphorylation at Thr-190 and phosphorylation at this site is essential for its function. Manganese,
    magnesium and cobalt-dependent autophosphorylation is mainly on threonine residues while zinc-dependent
    autophosphorylation is on both serine and threonine residues
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y6E0

  • 4/14 DME Specific Peptides for STK24 (Q9Y6E0) (see all 14)
     LLKHKFI  GITAIEL  LDYLHSE  WMAPEVI 

    STK24 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STK24 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001027467.2  NP_003567.2  

    ENSEMBL proteins: 
     ENSP00000365737   ENSP00000380651   ENSP00000365730   ENSP00000402810   ENSP00000402764  
     ENSP00000442539  
    Reactome Protein details: Q9Y6E0
    Human Recombinant Protein Products for STK24: 
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    Cloud-Clone Corp. Proteins for STK24 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12107159
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA12107159
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--

    STK24 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine kinase 24 
    YSK subfamily

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y6E0

    ProtoNet protein and cluster: Q9Y6E0

    UniProtKB/Swiss-Prot: STK24_HUMAN, Q9Y6E0
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    STK24 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STK24_HUMAN, Q9Y6E0
    Function: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis
    in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating
    phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress.
    Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear
    translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442'
    and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN
    phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through
    PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Biophysicochemical properties: Kinetic parameters: KM=12.8 uM for manganese ions; KM=34.9 uM for cobalt ions;
    KM=22.7 uM for magnesium ions; KM=4.1 uM for zinc ions; Vmax=2623.1 pmol/min/mg enzyme for manganese ions;
    Vmax=1746.1 pmol/min/mg enzyme for cobalt ions; Vmax=129.1 pmol/min/mg enzyme for magnesium ions; Vmax=22.3
    pmol/min/mg enzyme for zinc ions;

         Genatlas biochemistry entry for STK24:
    serine/threonine kinase 24,Ste20 yeast homolog

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9353338
    GO:0004674protein serine/threonine kinase activity IDA16314523
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16189514
    GO:0005524ATP binding IEA--
         
    STK24 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for STK24:
     Decreased Hepatitis C virus re  Decreased viability of wild-ty  Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Stk24 (no phenotypes)

    STK24 for phenotypes           About GeneDecksing

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STK24 
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    miRNA
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    miRTarBase miRNAs that target STK24:
    hsa-mir-141 (MIRT001813)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STK24
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate STK24 (see all 80):
    hsa-miR-300 hsa-miR-128 hsa-miR-502-3p hsa-miR-877* hsa-miR-508-5p hsa-miR-3148 hsa-miR-455-5p hsa-miR-186*
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STK24 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Apoptotic cleavage of cellular proteins
    Apoptotic cleavage of cellular proteins0.73
    Apoptotic execution phase0.73
    2CDK-mediated phosphorylation and removal of Cdc6
    Apoptosis0.39
    3Sweet Taste Signaling
    Sperm Motility0.37
    4Cytoskeletal Signaling
    Cytoskeletal Signaling
    5Apoptosis and Autophagy
    Apoptosis and Autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for STK24
        Sperm Motility

    2 Cell Signaling Technology (CST) Pathways for STK24
        Apoptosis and Autophagy
    Cytoskeletal Signaling


    3        Reactome Pathways for STK24
        Apoptotic execution phase
    Apoptotic cleavage of cellular proteins
    Apoptosis



    STK24 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STK24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/593 Interacting proteins for STK24 (Q9Y6E01, 2, 3 ENSP000003657304) via UniProtKB, MINT, STRING, and/or I2D (see all 593)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCT3P493682, 3, ENSP000003572444MINT-7947479 I2D: score=2 STRING: ENSP00000357244
    CCT4P509912, 3, ENSP000003779584MINT-7947479 I2D: score=2 STRING: ENSP00000377958
    CCT7Q998322, 3, ENSP000002580914MINT-7947479 I2D: score=2 STRING: ENSP00000258091
    CTTNBP2NLQ9P2B41, 3, ENSP000002712774EBI-740175,EBI-1774273 I2D: score=2 STRING: ENSP00000271277
    DDX5P178442, 3, ENSP000002257924MINT-7947479 I2D: score=2 STRING: ENSP00000225792
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA19604147
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0007165signal transduction TAS9353338
    GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress IMP19604147

    STK24 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STK24 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STK24

    3 HMDB Compounds for STK24    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Manganesemanganese 7439-96-5--

    1 Novoseek inferred chemical compound relationship for STK24 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 45.9 9 15917084 (3), 19782762 (1), 9353338 (1)

    Search CenterWatch for drugs/clinical trials and news about STK24

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STK24 gene (2 alternative transcripts): 
    NM_001032296.2  NM_003576.3  

    Unigene Cluster for STK24:

    Serine/threonine kinase 24
    Hs.508514  [show with all ESTs]
    Unigene Representative Sequence: NM_001032296
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376554 ENST00000397517(uc001vnm.1 uc001vnn.1 uc010tim.1)
    ENST00000376547 ENST00000418038 ENST00000444574 ENST00000491878 ENST00000481288
    ENST00000539966
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    hsa-miR-300 hsa-miR-128 hsa-miR-502-3p hsa-miR-877* hsa-miR-508-5p hsa-miR-3148 hsa-miR-455-5p hsa-miR-186*
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    Additional mRNA sequence: 

    AF024636.1 AF083420.1 AF339785.1 AF339826.1 AK297583.1 AK299140.1 BC035578.1 BC065378.1 
    BT019619.1 CR542227.1 

    17 DOTS entries:

    DT.448566  DT.40120476  DT.100811362  DT.97855737  DT.100811363  DT.100811371  DT.120778127  DT.120778162 
    DT.100811356  DT.120778106  DT.120778164  DT.120778188  DT.95214949  DT.97823882  DT.100638696  DT.100775992 
    DT.100782044 

    24/417 AceView cDNA sequences (see all 417):

    AW167142 CA432492 BM982223 AI718477 Z45569 BM741199 BQ945481 AL547571 
    AI569999 BE855927 CR607724 BF527442 BM741777 AA281138 BU731964 BM741908 
    AI355014 AI499465 CD105780 BU078073 CR601729 BQ045196 CB150252 CA435889 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for STK24 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                    -     -     -           -     -                                               -                                         -         
    SP2:                                            -     -                                               -                                                   
    SP3:                                                                                                                                                      
    SP4:                                            -     -                                                                                                   
    SP5:                    -     -     -           -     -           -     -                                                                                 


    ECgene alternative splicing isoforms for STK24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STK24 expression in normal human tissues (normalized intensities)      STK24 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCGCTCTC
    STK24 Expression
    About this image


    STK24 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See STK24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STK24

    SOURCE GeneReport for Unigene cluster: Hs.508514

    UniProtKB/Swiss-Prot: STK24_HUMAN, Q9Y6E0
    Tissue specificity: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus
    and cerebral cortex

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STK24 gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk241 , 5 serine/threonine kinase 24 (STE20 homolog, yeast)5
    serine/threonine kinase 241
    87.62(n)1
    97.14(a)1
      14 (64.95 cM)5
    2232551  NM_145465.21  NP_663440.11 
     1212863415 
    chicken
    (Gallus gallus)
    Aves STK241 serine/threonine kinase 24 78.18(n)
    90.09(a)
      418780  NM_001030817.1  NP_001025988.1 
    lizard
    (Anolis carolinensis)
    Reptilia STK246
    serine/threonine kinase 24
    89(a)
    1 ↔ 1
    3(98452523-98498092)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.30082 Xenopus laevis transcribed sequence with strong similarity more 81.75(n)    BX843050.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi29b082 Danio rerio cDNA clone MGC66137 IMAGE3817670, complete more 82.32(n)    BC054651.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51693 protein amino acid phosphorylation
    receptor signaling more
    73(a)   89E12   --
    worm
    (Caenorhabditis elegans)
    Secernentea gck-13 serine/threonine kinase 76(a)   V(8950405-8958008)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIC1(YHR102W)4 Protein kinase of the PAK/Ste20 family, required for more   --   8(316572-319814) 856502  NP_011970.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATMAP4K ALPHA11 map 4 kinase alpha1 61.05(n)
    62.2(a)
      841750  NM_001084239.1  NP_001077708.1 
    rice
    (Oryza sativa)
    Liliopsida Os.185932 Oryza sativa (japonica cultivar-group) cDNA clone0 more 76.88(n)    AK102538.1 


    ENSEMBL Gene Tree for STK24 (if available)
    TreeFam Gene Tree for STK24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STK24 gene
    STK42  STK252  STK32  MST42  
    18/51 SIMAP similar genes for STK24 using alignment to 9 protein entries:     STK24_HUMAN (see all proteins) (see all similar genes):
    STK25    DKFZp686J1430    MST4    STK3    MAP4K5    PAK2
    TAOK3    TAOK2    MAP4K3    PAK3    TAOK1    PAK1
    TNIK    MYO3A    MAP4K1    SLK    MAP4K4    STK4

    STK24 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STK24
    PGOHUM00000241570


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3047 SNPs in STK24 are shown (see all 3047)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs719633031,2
    C--80069792(+) TGCGC-/GTGT  
            
    GTGTG
    1 -- int10--------
    rs667602061,2
    C--80097886(+) CAGTA-/CAGAGTC 1 -- int12Minor allele frequency- CA:0.25NA 4
    rs412791221,2
    C,F--99102564(+) ATACAC/GAAGCT 2 -- ut312Minor allele frequency- G:0.11WA 120
    rs37421361,2
    C,F,A,H--99102607(-) TGTCAG/ATTTAT 2 -- ut3112Minor allele frequency- A:0.18EA NS NA WA 2252
    rs796066891,2
    C,F--99102630(+) AGGAAA/GGGTAC 2 -- ut311Minor allele frequency- G:0.03WA 118
    rs1171121861,2
    C,F--99102675(+) ACAAGA/GGCAAT 2 -- ut311Minor allele frequency- G:0.01NA 120
    rs1486778331,2
    C--99102688(+) GGGAT-/ATAAAA 1 -- ut310--------
    rs757629251,2
    C--99102807(+) AGGACA/GCAGCT 2 -- ut310--------
    rs735562241,2
    C,F--99102815(+) GCTCAA/GAAACG 2 -- ut312Minor allele frequency- G:0.04WA 120
    rs1899089741,2
    --99102825(+) GCAGGA/GGCTAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for STK24 (99102455 - 99230194 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for STK24 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2747858CNV Deletion23290073
    esv2747857CNV Deletion23290073
    nsv509511CNV Insertion20534489
    esv1791098CNV Insertion17803354
    nsv1142CNV Insertion18451855
    nsv1141CNV Insertion18451855
    nsv513394CNV Insertion21212237
    nsv832695CNV Loss17160897
    nsv456089CNV Loss19166990
    esv26178CNV Loss19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604984    OMIM disorders: --

    12 diseases for STK24:    About MalaCards
    pseudohypoaldosteronism    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation
    cerebritis    bipolar disorder    pancreatic cancer    schizophrenia
    hypoxia    pancreatitis    alzheimer's disease    neuronitis


    STK24 for disorders           About GeneDecksing

    Genetic Association Database (GAD): STK24
    Human Genome Epidemiology (HuGE) Navigator: STK24 (3 documents)

    Export disorders for STK24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STK24 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with STK24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human brain-specific isoform of mammalian STE20- like kinase 3 that is regulated by cAMP-dependent protein kinase. (PubMed id 10644707)1, 2, 3, 9 Zhou T.-H....Pei G. (2000)
    2. Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. (PubMed id 9353338)1, 2, 3, 9 Schinkmann K. and Blenis J. (1997)
    3. Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis. (PubMed id 12107159)1, 2, 9 Huang C.Y....Yuan C.J. (2002)
    4. Mammalian sterile 20-like kinase 3 (MST3) mediates ox idative-stress-induced cell death by modulating JNK activation. (PubMed id 19604147)1, 2, 9 Chen C.B....Porter A.G. (2009)
    5. Mammalian Ste20-like protein kinase 3 induces a caspa se-independent apoptotic pathway. (PubMed id 19782762)1, 2, 9 Lin C.Y....Yuan C.J. (2010)
    6. Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3. (PubMed id 16314523)1, 2, 9 Stegert M.R....Hemmings B.A. (2005)
    7. Identification and characterization of the nuclear import and export signals of the mammalian Ste20-like protein kinase 3. (PubMed id 15304321)1, 2, 9 Lee W.S....Yuan C.J. (2004)
    8. A comprehensive genetic association study of Alzheimer disease in African Americans. (PubMed id 22159054)1, 4 Logue M.W....Farrer L.A. (2011)
    9. Joint influence of small-effect genetic variants on h uman longevity. (PubMed id 20834067)1, 4 Yashin A.I....Ukraintseva S.V. (2010)
    10. Structures of human MST3 kinase in complex with adeni ne, ADP and Mn2+. (PubMed id 20124694)1, 2 Ko T.P....Wang A.H. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8428 HGNC: 11403 AceView: STK24 Ensembl:ENSG00000102572 euGenes: HUgn8428
    ECgene: STK24 H-InvDB: STK24

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STK24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STK24 gene:
    Search GeneIP for patents involving STK24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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