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STK24 Gene

protein-coding   GIFtS: 67
GCID: GC13M099103

Serine/Threonine Kinase 24

(Previous names: serine/threonine kinase 24 (Ste20, yeast homolog))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Threonine Kinase 241 2     Serine/Threonine Kinase 24 (Ste20, Yeast Homolog)1
MST32 3 5     HEL-S-952
STE20-Like Kinase 31 2     STE202
Sterile 20-Like Kinase 31 2     Epididymis Secretory Protein Li 952
Mammalian STE20-Like Protein Kinase 32 3     Serine/Threonine Kinase 24 (STE20 Homolog, Yeast)2
STK32 3     Serine/Threonine-Protein Kinase 242
STE20-Like Kinase MST32 3     MST-33
EC 2.7.11.13 8     EC 2.7.118
MST3B2 5     

External Ids:    HGNC: 114031   Entrez Gene: 84282   Ensembl: ENSG000001025727   OMIM: 6049845   UniProtKB: Q9Y6E03   

Export aliases for STK24 gene to outside databases

Previous GC identifers: GC13M097464 GC13M093491 GC13M097941 GC13M096802 GC13M097902 GC13M079700


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STK24 Gene:
This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase
(MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N)
translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on
chromosome X. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2013)

GeneCards Summary for STK24 Gene:
STK24 (serine/threonine kinase 24) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is STK4.

UniProtKB/Swiss-Prot: STK24_HUMAN, Q9Y6E0
Function: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis
in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating
phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress.
Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear
translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442'
and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN
phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through
PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve

Gene Wiki entry for STK24 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_009952.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STK24 gene promoter:
         AhR   Pbx1a   HSF1 (long)   Roaz   Arnt   FOXJ2 (long isoform)   HSF1short   FOXO1a   FOXJ2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK24 promoter sequence
   Search Chromatin IP Primers for STK24

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31.2-q32.3   Ensembl cytogenetic band:  13q32.2   HGNC cytogenetic band: 13q31.2-q32.3

STK24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK24 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M099103:  view genomic region     (about GC identifiers)

Start:
99,102,455 bp from pter      End:
99,230,194 bp from pter
Size:
127,740 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: STK24_HUMAN, Q9Y6E0 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 24  
Size: 443 amino acids; 49308 Da
Cofactor: Mg(2+) or Mn(2+) or Co(2+) or Zn(2+)
Subunit: Monomer. Interacts with CTTNBP2NL
Selected PDB 3D structures from and Proteopedia for STK24 (see all 8):
3A7F (3D)        3A7G (3D)        3A7H (3D)        3A7I (3D)        3A7J (3D)        3CKW (3D)    
Secondary accessions: O14840 Q5JV92
Alternative splicing: 2 isoforms:  Q9Y6E0-1   Q9Y6E0-2   (Initiator Met-1 is removed. Contains a phosphoserine at position 4. Contains a N-acetylalanine at position 2)

Explore the universe of human proteins at neXtProt for STK24: NX_Q9Y6E0

Explore proteomics data for STK24 at MOPED

Post-translational modifications: 

  • Proteolytically processed by caspases during apoptosis. Proteolytic cleavage results in kinase activation, nuclear
    translocation of the truncated form (MST3/N) and the induction of apoptosis1
  • Isoform B is activated by phosphorylation by PKA. Oxidative stress induces phosphorylation. Activated by
    autophosphorylation at Thr-190 and phosphorylation at this site is essential for its function. Manganese,
    magnesium and cobalt-dependent autophosphorylation is mainly on threonine residues while zinc-dependent
    autophosphorylation is on both serine and threonine residues1
  • Ubiquitination2 at Lys187, Lys238, Lys292
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for STK24 (Q9Y6E0) (see all 14)
     LLKHKFI  GITAIEL  LDYLHSE  WMAPEVI 


    See STK24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001027467.2  NP_001273578.1  NP_003567.2  

    ENSEMBL proteins: 
     ENSP00000365737   ENSP00000380651   ENSP00000365730   ENSP00000402810   ENSP00000402764  
     ENSP00000442539  
    Reactome Protein details: Q9Y6E0

    STK24 Human Recombinant Protein Products:

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    Novus Biologicals STK24 Proteins
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    Sino Biological Recombinant Protein for STK24
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    Cloud-Clone Corp. Proteins for STK24

     
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    antibodies-online proteins for STK24 (4 products) 

     
    antibodies-online peptides for STK24

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine kinase 24
    YSK subfamily

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y6E0

    ProtoNet protein and cluster: Q9Y6E0

    UniProtKB/Swiss-Prot: STK24_HUMAN, Q9Y6E0
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with STK24           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STK24_HUMAN, Q9Y6E0
    Function: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis
    in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating
    phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress.
    Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear
    translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442'
    and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN
    phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through
    PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Biophysicochemical properties: Kinetic parameters: KM=12.8 uM for manganese ions; KM=34.9 uM for cobalt ions;
    KM=22.7 uM for magnesium ions; KM=4.1 uM for zinc ions; Vmax=2623.1 pmol/min/mg enzyme for manganese ions;
    Vmax=1746.1 pmol/min/mg enzyme for cobalt ions; Vmax=129.1 pmol/min/mg enzyme for magnesium ions; Vmax=22.3
    pmol/min/mg enzyme for zinc ions;

         Genatlas biochemistry entry for STK24:
    serine/threonine kinase 24,Ste20 yeast homolog

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9353338
    GO:0004674protein serine/threonine kinase activity IDA16314523
    GO:0004702receptor signaling protein serine/threonine kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with STK24           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for STK24:
     Decreased Hepatitis C virus re  Decreased viability of wild-ty  Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Stk24 (no phenotypes)

    Find genes that share phenotypes with STK24           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for STK24

    miRNA
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    miRTarBase miRNAs that target STK24:
    hsa-mir-186-5p (MIRT045062), hsa-mir-877-3p (MIRT036877), hsa-mir-1 (MIRT023521), hsa-mir-155-5p (MIRT020540)

    Block miRNA regulation of human, mouse, rat STK24 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK24 (see all 80):
    hsa-miR-300 hsa-miR-128 hsa-miR-502-3p hsa-miR-877* hsa-miR-508-5p hsa-miR-3148 hsa-miR-455-5p hsa-miR-186*
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK24


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STK24_HUMAN, Q9Y6E0: Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus.
    Colocalizes with STK38L in the membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12107159
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with STK24           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STK24 About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptotic cleavage of cellular proteins
    Apoptotic cleavage of cellular proteins0.74
    Apoptotic execution phase0.74
    2CDK-mediated phosphorylation and removal of Cdc6
    Apoptosis0.38
    3Sweet Taste Signaling
    Sperm Motility0.37
    4Cytoskeletal Signaling
    Cytoskeletal Signaling
    5Apoptosis and Autophagy
    Apoptosis and Autophagy


    Find genes that share SuperPaths with STK24           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STK24
        Sperm Motility

    2 Cell Signaling Technology (CST) Pathways for STK24
        Apoptosis and Autophagy
    Cytoskeletal Signaling


    2 Reactome Pathways for STK24
        Apoptotic execution phase
    Apoptotic cleavage of cellular proteins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STK24
    Interactions:

        Search GeneGlobe Interaction Network for STK24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STK24 (Q9Y6E01, 2, 3 ENSP000003657304) via UniProtKB, MINT, STRING, and/or I2D (see all 619)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCT3P493682, 3, ENSP000003572444MINT-7947479 I2D: score=2 STRING: ENSP00000357244
    CCT4P509912, 3, ENSP000003779584MINT-7947479 I2D: score=2 STRING: ENSP00000377958
    CCT7Q998322, 3, ENSP000002580914MINT-7947479 I2D: score=2 STRING: ENSP00000258091
    CTTNBP2NLQ9P2B41, 3, ENSP000002712774EBI-740175,EBI-1774273 I2D: score=2 STRING: ENSP00000271277
    DDX5P178442, 3, ENSP000002257924MINT-7947479 I2D: score=2 STRING: ENSP00000225792
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA19604147
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0007165signal transduction TAS9353338
    GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress IMP19604147

    Find genes that share ontologies with STK24           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STK24

    3 HMDB Compounds for STK24    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Manganesemanganese 7439-96-5--

    1 Novoseek inferred chemical compound relationship for STK24 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 45.9 9 15917084 (3), 19782762 (1), 9353338 (1)



    Find genes that share compounds with STK24           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STK24 gene (3 alternative transcripts): 
    NM_001032296.3  NM_001286649.1  NM_003576.4  

    Unigene Cluster for STK24:

    Serine/threonine kinase 24
    Hs.508514  [show with all ESTs]
    Unigene Representative Sequence: NM_001032296
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376554 ENST00000397517(uc001vnm.1 uc001vnn.1 uc010tim.1)
    ENST00000376547 ENST00000418038 ENST00000444574 ENST00000491878 ENST00000481288
    ENST00000539966
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    hsa-miR-300 hsa-miR-128 hsa-miR-502-3p hsa-miR-877* hsa-miR-508-5p hsa-miR-3148 hsa-miR-455-5p hsa-miR-186*
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    Additional mRNA sequence: 

    AF024636.1 AF083420.1 AF339785.1 AF339826.1 AK297583.1 AK299140.1 BC035578.1 BC065378.1 
    BT019619.1 CR542227.1 

    17 DOTS entries:

    DT.448566  DT.40120476  DT.100811362  DT.97855737  DT.100811363  DT.100811371  DT.120778127  DT.120778162 
    DT.100811356  DT.120778106  DT.120778164  DT.120778188  DT.95214949  DT.97823882  DT.100638696  DT.100775992 
    DT.100782044 

    Selected AceView cDNA sequences (see all 417):

    AI355014 BG054874 Z45569 AI378161 BU682411 BM968437 AI017638 H11876 
    BF593790 AA250836 AW167142 BU619871 BQ679213 AW167263 CA435889 AL135267 
    AW291995 BM662129 CA432228 AA251999 AL547571 BM768370 BE855927 BP375547 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STK24 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                    -     -     -           -     -                                               -                                         -         
    SP2:                                            -     -                                               -                                                   
    SP3:                                                                                                                                                      
    SP4:                                            -     -                                                                                                   
    SP5:                    -     -     -           -     -           -     -                                                                                 


    ECgene alternative splicing isoforms for STK24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STK24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCGCTCTC
    STK24 Expression
    About this image


    STK24 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    STK24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STK24 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.508514

    UniProtKB/Swiss-Prot: STK24_HUMAN, Q9Y6E0
    Tissue specificity: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus
    and cerebral cortex

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STK24 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk241 , 5 serine/threonine kinase 24 (STE20 homolog, yeast)5
    serine/threonine kinase 241
    88.17(n)1
    97.68(a)1
      14 (64.95 cM)5
    2232551  NM_145465.21  NP_663440.11 
     1212863415 
    chicken
    (Gallus gallus)
    Aves STK241 serine/threonine kinase 24 78.18(n)
    90.09(a)
      418780  NM_001030817.1  NP_001025988.1 
    lizard
    (Anolis carolinensis)
    Reptilia STK246
    serine/threonine kinase 24
    89(a)
    1 ↔ 1
    3(98452523-98498092)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.30082 Xenopus laevis transcribed sequence with strong similarity more 81.75(n)    BX843050.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi29b082 Danio rerio cDNA clone MGC66137 IMAGE3817670, complete more 82.32(n)    BC054651.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51693 protein amino acid phosphorylation
    receptor signaling more
    73(a)   89E12   --
    worm
    (Caenorhabditis elegans)
    Secernentea gck-13 serine/threonine kinase 76(a)   V(8950405-8958008)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIC1(YHR102W)4 Protein kinase of the PAK/Ste20 family, required for more   --   8(316572-319814) 856502  NP_011970.1 
    rice
    (Oryza sativa)
    Liliopsida Os.185932 Oryza sativa (japonica cultivar-group) cDNA clone0 more 76.88(n)    AK102538.1 


    ENSEMBL Gene Tree for STK24 (if available)
    TreeFam Gene Tree for STK24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STK24 gene
    STK42  STK252  STK32  MST42  
    Selected SIMAP similar genes for STK24 using alignment to 9 protein entries:     STK24_HUMAN (see all proteins) (see all similar genes):
    STK25    DKFZp686J1430    MST4    STK3    MAP4K5    PAK2
    TAOK3    TAOK2    MAP4K3    PAK3    TAOK1    PAK1
    TNIK    MYO3A    MAP4K1    SLK    MAP4K4    STK4

    Find genes that share paralogs with STK24           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for STK24
    PGOHUM00000241570


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STK24 (see all 3047)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs719633031,2
    C--80069792(+) TGCGC-/GTGT  
            
    GTGTG
    1 -- int10--------
    rs667602061,2
    C--80097886(+) CAGTA-/CAGAGTC 1 -- int12Minor allele frequency- CA:0.25NA 4
    rs412791221,2
    C,F--99102564(+) ATACAC/GAAGCT 2 -- ut312Minor allele frequency- G:0.11WA 120
    rs37421361,2
    C,F,A,H--99102607(-) TGTCAG/ATTTAT 2 -- ut3112Minor allele frequency- A:0.18EA NS NA WA 2252
    rs796066891,2
    C,F--99102630(+) AGGAAA/GGGTAC 2 -- ut311Minor allele frequency- G:0.03WA 118
    rs1171121861,2
    C,F--99102675(+) ACAAGA/GGCAAT 2 -- ut311Minor allele frequency- G:0.01NA 120
    rs1486778331,2
    C--99102688(+) GGGAT-/ATAAAA 1 -- ut310--------
    rs757629251,2
    C--99102807(+) AGGACA/GCAGCT 2 -- ut310--------
    rs735562241,2
    C,F--99102815(+) GCTCAA/GAAACG 2 -- ut312Minor allele frequency- G:0.04WA 120
    rs1899089741,2
    --99102825(+) GCAGGA/GGCTAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for STK24 (99102455 - 99230194 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STK24 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747858CNV Deletion23290073
    esv2747857CNV Deletion23290073
    nsv509511CNV Insertion20534489
    esv1791098CNV Insertion17803354
    nsv1142CNV Insertion18451855
    nsv1141CNV Insertion18451855
    nsv513394CNV Insertion21212237
    nsv832695CNV Loss17160897
    nsv456089CNV Loss19166990
    esv26178CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STK24
    DNA2.0 Custom Variant and Variant Library Synthesis for STK24

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604984    OMIM disorders: --


    Find genes that share disorders with STK24           About GenesLikeMe

    Genetic Association Database (GAD): STK24
    Human Genome Epidemiology (HuGE) Navigator: STK24 (3 documents)

    Export disorders for STK24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STK24 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with STK24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human brain-specific isoform of mammalian STE20- like kinase 3 that is regulated by cAMP-dependent protein kinase. (PubMed id 10644707)1, 2, 3, 9 Zhou T.-H....Pei G. (J. Biol. Chem. 2000)
    2. Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. (PubMed id 9353338)1, 2, 3, 9 Schinkmann K. and Blenis J. (J. Biol. Chem. 1997)
    3. Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). (PubMed id 12107159)1, 2, 9 Huang C.Y....Yuan C.J. (J. Biol. Chem. 2002)
    4. Zinc ion acts as a cofactor for serine/threonine kinase MST3 and has a distinct role in autophosphorylation of MST3. (PubMed id 15917084)1, 2, 9 Lu T.J.... Lai M.D. (J. Inorg. Biochem. 2005)
    5. Mammalian sterile 20-like kinase 3 (MST3) mediates oxidative-stress- induced cell death by modulating JNK activation. (PubMed id 19604147)1, 2, 9 Chen C.B.... Porter A.G. (Biosci. Rep. 2009)
    6. Mammalian Ste20-like protein kinase 3 induces a caspase-independent apoptotic pathway. (PubMed id 19782762)1, 2, 9 Lin C.Y.... Yuan C.J. (Int. J. Biochem. Cell Biol. 2010)
    7. Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3. (PubMed id 16314523)1, 2, 9 Stegert M.R....Hemmings B.A. (Mol. Cell. Biol. 2005)
    8. Identification and characterization of the nuclear import and export signals of the mammalian Ste20-like protein kinase 3. (PubMed id 15304321)1, 2, 9 Lee W.S.... Yuan C.J. (FEBS Lett. 2004)
    9. A comprehensive genetic association study of Alzheimer disease in African Americans. (PubMed id 22159054)1, 4 Logue M.W....Farrer L.A. (Arch. Neurol. 2011)
    10. Joint influence of small-effect genetic variants on human longevity. (PubMed id 20834067)1, 4 Yashin A.I....Ukraintseva S.V. (Aging (Albany NY) 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8428 HGNC: 11403 AceView: STK24 Ensembl:ENSG00000102572 euGenes: HUgn8428
    ECgene: STK24 H-InvDB: STK24

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STK24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STK24 gene:
    Search GeneIP for patents involving STK24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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