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STK19 Gene

protein-coding   GIFtS: 58
GCID: GC06P031938

Serine/Threonine Kinase 19

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Serine/Threonine Kinase 191 2     MHC Class III HLA-RP12
G112 3     Nuclear Serine/Threonine Protein Kinase2
RP12 3     Serine/Threonine-Protein Kinase 192
D6S602     EC 2.7.11.13
D6S60E2     Protein G113
HLA-RP12     Protein RP13

External Ids:    HGNC: 113981   Entrez Gene: 88592   Ensembl: ENSG000002043447   OMIM: 6049775   UniProtKB: P498423   
ORGUL members:         

Export aliases for STK19 gene to outside databases

Previous GC identifers: GC06P032001 GC06P031710 GC06P032043 GC06P032047 GC06P031725


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STK19 Gene:
This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is
unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene
localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two
transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for STK19 Gene:
STK19 (serine/threonine kinase 19) is a protein-coding gene. Diseases associated with STK19 include orchitis, and 21-hydroxylase deficiency. GO annotations related to this gene include protein serine/threonine kinase activity.

UniProtKB/Swiss-Prot: STK19_HUMAN, P49842
Function: Seems to be a protein kinase. In vitro it can phosphorylate casein-alpha on serine and threonine
residues and histones on serine residues

Gene Wiki entry for STK19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167247.2  NT_167248.2  NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STK19 gene promoter:
         E2F-4   Max   E2F-5   Pax-5   AP-1   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): STK19 promoter sequence
   Search Chromatin IP Primers for STK19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.33

STK19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK19 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031938:  view genomic region     (about GC identifiers)

Start:
31,938,868 bp from pter      End:
31,950,598 bp from pter
Size:
11,731 bases      Orientation:
plus strand

5 alternative locations:
Chr6+,NT_167249 3,271,662-3,281,933      Chr6+,NT_167247 3,318,796-3,329,068      Chr6+,NT_167248 3,232,741-3,243,013     
Chr6+,NT_113891.2 3,448,708-3,458,979      Chr6+,NT_167245 3,224,535-3,234,804     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: STK19_HUMAN, P49842 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 19  
Size: 368 amino acids; 40916 Da
Cofactor: Divalent cations. Has a preference for manganese
Subunit: The N-terminus interacts with BAG1
Secondary accessions: A6NF95 A6NFW8 B0QZR5 Q13159 Q31617 Q5JP77 Q5ST72 Q5ST75
Alternative splicing: 4 isoforms:  P49842-1   P49842-2   P49842-3   P49842-4   

Explore the universe of human proteins at neXtProt for STK19: NX_P49842

Explore proteomics data for STK19 at MOPED


See STK19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_004188.1  NP_115830.1  

ENSEMBL proteins: 
 ENSP00000418350   ENSP00000364480   ENSP00000364482   ENSP00000418866   ENSP00000454870  

STK19 Human Recombinant Protein Products:

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STK19 Assay Products:

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Cloud-Clone Corp. CLIAs for STK19


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine kinase 19
G11 family

1 InterPro protein domain:
 IPR018865 Ser/Thr_kinase_19

Graphical View of Domain Structure for InterPro Entry P49842

ProtoNet protein and cluster: P49842

UniProtKB/Swiss-Prot: STK19_HUMAN, P49842
Similarity: Belongs to the STK19 family


STK19 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: STK19_HUMAN, P49842
Function: Seems to be a protein kinase. In vitro it can phosphorylate casein-alpha on serine and threonine
residues and histones on serine residues
Catalytic activity: ATP + a protein = ADP + a phosphoprotein

     Genatlas biochemistry entry for STK19:
serine/threonine 19,widely expressed

     Enzyme Number (IUBMB): EC 2.7.11.11

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004674protein serine/threonine kinase activity IEA--
GO:0005524ATP binding IEA--
     
STK19 for ontologies           About GeneDecksing


Phenotypes:
     5 GenomeRNAi human phenotypes for STK19:
 Decreased 12E8 and total tau p  Decreased focal adhesion (FA)   Decreased nuclei size in G2M  Decreased substrate adherent c 
 Decreased telomerase activity 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STK19
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STK19

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STK19
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STK19

miRNA
Products:
    
miRTarBase miRNAs that target STK19:
hsa-mir-29c-3p (MIRT044241)

Block miRNA regulation of human, mouse, rat STK19 using miScript Target Protectors
5 qRT-PCR Assays for microRNAs that regulate STK19:
hsa-miR-182 hsa-miR-3202 hsa-miR-1271 hsa-miR-4290 hsa-miR-96
SwitchGear 3'UTR luciferase reporter plasmidSTK19 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for STK19
Predesigned siRNA for gene silencing in human, mouse, rat STK19

Gene Editing
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GenScript: all cDNA clones in your preferred vector (see all 2): STK19 (NM_004197)
Sino Biological Human cDNA Clone for STK19
DNA2.0 Custom Codon Optimized Gene Synthesis Service for STK19
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK19

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK19


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
STK19_HUMAN, P49842: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol2
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

STK19 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for STK19 About    
See pathways by source

SuperPathContained pathways About
1Sweet Taste Signaling
Sperm Motility0.37

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STK19
    Sperm Motility



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STK19
Interactions:

    Search GeneGlobe Interaction Network for STK19

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for STK19 (P498422, 3 ENSP000003644824) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
POLR2GP624872, 3, ENSP000003017884MINT-62582 MINT-62756 MINT-62680 I2D: score=5 STRING: ENSP00000301788
SLC29A1Q998082, 3, ENSP000003607734MINT-62585 MINT-62759 MINT-62683 I2D: score=5 STRING: ENSP00000360773
PRAMEP783952, 3MINT-62760 MINT-62684 MINT-62586 I2D: score=5 
SF3B4Q154272, 3, ENSP000002716284MINT-62583 MINT-62681 MINT-62757 I2D: score=4 STRING: ENSP00000271628
SP3Q024472, 3, ENSP000003103014MINT-62758 MINT-62584 MINT-62682 I2D: score=5 STRING: ENSP00000310301
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006468protein phosphorylation TAS9812991

STK19 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for STK19

1 HMDB Compound for STK19    About this table
CompoundSynonyms CAS #PubMed Ids
Manganesemanganese 7439-96-5--

3 Novoseek inferred chemical compound relationships for STK19 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
threonine 50.6 2 14730433 (1), 9812991 (1)
leucine 40.7 1 11487501 (1)
serine 37.7 2 14730433 (1), 9812991 (1)



STK19 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for STK19 gene (2 alternative transcripts): 
NM_004197.1  NM_032454.1  

Unigene Cluster for STK19:

Serine/threonine kinase 19
Hs.654371  [show with all ESTs]
Unigene Representative Sequence: BC110347
17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000466132(uc003nyt.3 uc011dox.1) ENST00000460018 ENST00000479644(uc011dow.2)
ENST00000375331(uc003nyv.3 uc003nyw.3) ENST00000492583 ENST00000375333
ENST00000473983 ENST00000478486 ENST00000463823 ENST00000483801 ENST00000519179(uc010jtn.1)
ENST00000466336 ENST00000471028 ENST00000491861 ENST00000484540 ENST00000469907
ENST00000490822

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat STK19 using miScript Target Protectors
5 qRT-PCR Assays for microRNAs that regulate STK19:
hsa-miR-182 hsa-miR-3202 hsa-miR-1271 hsa-miR-4290 hsa-miR-96
SwitchGear 3'UTR luciferase reporter plasmidSTK19 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for STK19
Predesigned siRNA for gene silencing in human, mouse, rat STK19
Clone
Products:
     
OriGene clones in human, mouse for STK19 (see all 13)
OriGene ORF clones in mouse, rat for STK19
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): STK19 (NM_004197)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for STK19
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK19
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for STK19
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STK19
  QuantiTect SYBR Green Assays in human, mouse, rat STK19
  QuantiFast Probe-based Assays in human, mouse, rat STK19

Additional mRNA sequence: 

AK302111.1 AK303438.1 AK307198.1 BC016916.1 BC110347.1 BC121128.1 BC121129.1 BC143833.1 
BC143835.1 L26260.1 NR_026717.1 X77386.1 

19 DOTS entries:

DT.100816356  DT.447275  DT.121361862  DT.112296  DT.91752624  DT.100651903  DT.91886413  DT.121361941 
DT.95376283  DT.99971224  DT.70105173  DT.91752622  DT.95296222  DT.75104153  DT.91680425  DT.95344329 
DT.97808774  DT.121361728  DT.121361950 

Selected AceView cDNA sequences (see all 86):

CD742645 BQ925245 AI973206 NM_004197 W81583 BG339903 BU624370 CB853400 
CD671893 CR602611 CR605584 BQ709330 BE645152 CD673228 L26260 NM_032454 
BM467781 BM706985 CB140909 AL552424 BC016916 AI245636 BQ009080 BI754476 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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STK19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTAAAATTGC
STK19 Expression
About this image

STK19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

STK19 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.654371

UniProtKB/Swiss-Prot: STK19_HUMAN, P49842
Tissue specificity: Monocytes, hepatocytes, epithelial cells, T- and B-lymphocytes

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK19

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for STK19 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Stk191 , 5 serine/threonine kinase 191, 5 82.41(n)1
85.83(a)1
  17 (18.38 cM)5
544021  NM_019442.31  NP_062315.11 
 348239935 
lizard
(Anolis carolinensis)
Reptilia STK196
serine/threonine kinase 19
53(a)
1 ↔ 1
2(194130739-194139791)
African clawed frog
(Xenopus laevis)
Amphibia Xl.225072 Xenopus laevis transcribed sequence with weak similarity more 74.82(n)    48033996 
zebrafish
(Danio rerio)
Actinopterygii LOC1001504971 serine/threonine-protein kinase 19-like 59.59(n)
55.1(a)
  100150497  XM_001923271.4  XP_001923306.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G204951 AT2G20495 45.48(n)
35.47(a)
  816570  NM_179670.3  NP_850001.3 
rice
(Oryza sativa)
Liliopsida Os07g04588001 Os07g0458800 44.17(n)
33.75(a)
  4343157  NM_001066106.1  NP_001059571.1 


ENSEMBL Gene Tree for STK19 (if available)
TreeFam Gene Tree for STK19 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for STK19 (see all 107)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0423614
A metastatic melanoma sample4--see VAR_0423612 D N mis40--------
rs114044311,2
C--31942057(+) AAAAA-/AGTAAC 3 -- int1 trp31Minor allele frequency- A:0.00NA 2
rs3773701,2
C,F,A,H--31942514(-) tctgtT/Caccca 3 -- int17Minor allele frequency- C:0.25NA CSA WA 248
rs1807458781,2
--31942550(+) AAAACA/CACAAC 3 -- int10--------
rs557126381,2
C--31942732(+) AAGGAA/GTATTT 3 -- int10--------
rs742905271,2
C--31942872(+) AAACTA/GTAGAA 3 -- int10--------
rs1413466721,2
--31943008(+) GAGTGC/TCGCTC 3 -- int10--------
rs1860031151,2
C--31943035(+) GTGCAA/GTGGTG 3 -- int10--------
rs1899137271,2
--31943206(+) ATCTCC/TTGACC 3 -- int10--------
rs413158121,2
C--31943232(+) CTCGGC/TCTCCC 3 -- int10--------

HapMap Linkage Disequilibrium report for STK19 (31938868 - 31950598 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for STK19 (see all 49):    About this table    
Variant IDTypeSubtypePubMed ID
esv2731825CNV Deletion23290073
esv2666636CNV Deletion23128226
dgv20n31CNV Duplication19718026
nsv884665CNV Loss21882294
dgv6631n71CNV Loss21882294
nsv884626CNV Loss21882294
nsv285CNV Loss15895083
dgv6609n71CNV Loss21882294
nsv884514CNV Loss21882294
dgv6624n71CNV Loss21882294

Human Gene Mutation Database (HGMD): STK19
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing STK19
DNA2.0 Custom Variant and Variant Library Synthesis for STK19

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604977    OMIM disorders: --

10 diseases for STK19:    
About MalaCards
orchitis    21-hydroxylase deficiency    diarrhea    childhood leukemia
systemic lupus erythematosus    meningioma    lupus erythematosus    schizophrenia
hiv-1    leukemia


STK19 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Genetic Association Database (GAD): STK19
Human Genome Epidemiology (HuGE) Navigator: STK19 (11 documents)

Export disorders for STK19 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for STK19 gene, integrated from 10 sources (see all 27):
(articles sorted by number of sources associating them with STK19)
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  1. The G11 gene located in the major histocompatibility complex encodes a novel nuclear serine/threonine protein kinase. (PubMed id 9812991)1, 2, 3, 9 Gomez-Escobar N.... Campbell R.D. (J. Biol. Chem. 1998)
  2. Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex. (PubMed id 8012361)1, 2, 3, 9 Sargent C.A.... Campbell R.D. (Hum. Mol. Genet. 1994)
  3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
  4. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
  5. Host determinants of HIV-1 control in African Americans. (PubMed id 20205591)1, 4 Pelak K.... . (J. Infect. Dis. 2010)
  6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  7. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
  8. Characterization of Hap/BAG-1 variants as RP1 binding proteins with antiapoptotic activity. (PubMed id 15986447)1, 2 Wadle A.... Renner C. (Int. J. Cancer 2005)
  9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
  10. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (Genome Res. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8859 HGNC: 11398 AceView: STK19 Ensembl:ENSG00000204344 euGenes: HUgn8859
ECgene: STK19 H-InvDB: STK19

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for STK19 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for STK19 gene:
Search GeneIP for patents involving STK19

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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