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Aliases for STK19 Gene

Aliases for STK19 Gene

  • Serine/Threonine Kinase 19 2 3 5
  • RP1 3 4
  • G11 3 4
  • Nuclear Serine/Threonine Protein Kinase 3
  • MHC Class III HLA-RP1 3
  • Protein G11 4
  • Protein RP1 4
  • EC 4
  • HLA-RP1 3
  • D6S60E 3
  • D6S60 3

External Ids for STK19 Gene

Previous GeneCards Identifiers for STK19 Gene

  • GC06P032001
  • GC06P031710
  • GC06P032043
  • GC06P032047
  • GC06P031938
  • GC06P031725

Summaries for STK19 Gene

Entrez Gene Summary for STK19 Gene

  • This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK19 Gene

STK19 (Serine/Threonine Kinase 19) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include protein serine/threonine kinase activity.

UniProtKB/Swiss-Prot for STK19 Gene

  • Seems to be a protein kinase. In vitro it can phosphorylate casein-alpha on serine and threonine residues and histones on serine residues.

Gene Wiki entry for STK19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK19 Gene

Genomics for STK19 Gene

Regulatory Elements for STK19 Gene

Enhancers for STK19 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STK19 on UCSC Golden Path with GeneCards custom track

Promoters for STK19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STK19 on UCSC Golden Path with GeneCards custom track

Genomic Location for STK19 Gene

31,971,091 bp from pter
31,982,821 bp from pter
11,731 bases
Plus strand

Genomic View for STK19 Gene

Genes around STK19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for STK19 Gene

  • Protein details for STK19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase 19
    Protein Accession:
    Secondary Accessions:
    • A6NF95
    • A6NFW8
    • B0QZR5
    • Q13159
    • Q31617
    • Q5JP77
    • Q5ST72
    • Q5ST75

    Protein attributes for STK19 Gene

    368 amino acids
    Molecular mass:
    40916 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • The N-terminus interacts with BAG1.

    Alternative splice isoforms for STK19 Gene


neXtProt entry for STK19 Gene

Proteomics data for STK19 Gene at MOPED

Post-translational modifications for STK19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STK19 Gene

No data available for DME Specific Peptides for STK19 Gene

Domains & Families for STK19 Gene

Gene Families for STK19 Gene

Protein Domains for STK19 Gene


Suggested Antigen Peptide Sequences for STK19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the STK19 family.
  • Belongs to the STK19 family.
genes like me logo Genes that share domains with STK19: view

Function for STK19 Gene

Molecular function for STK19 Gene

GENATLAS Biochemistry:
serine/threonine 19,widely expressed
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Seems to be a protein kinase. In vitro it can phosphorylate casein-alpha on serine and threonine residues and histones on serine residues.

Enzyme Numbers (IUBMB) for STK19 Gene

Gene Ontology (GO) - Molecular Function for STK19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with STK19: view
genes like me logo Genes that share phenotypes with STK19: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STK19

CRISPR Products

miRNA for STK19 Gene

miRTarBase miRNAs that target STK19

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK19 Gene

Localization for STK19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK19 Gene

Subcellular locations from

Jensen Localization Image for STK19 Gene COMPARTMENTS Subcellular localization image for STK19 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for STK19 Gene

Pathways & Interactions for STK19 Gene

SuperPathways for STK19 Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK19: view

Pathways by source for STK19 Gene

1 Qiagen pathway for STK19 Gene

Gene Ontology (GO) - Biological Process for STK19 Gene


No data available for SIGNOR curated interactions for STK19 Gene

Drugs & Compounds for STK19 Gene

(4) Drugs for STK19 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Pharma 32
genes like me logo Genes that share compounds with STK19: view

Transcripts for STK19 Gene

Unigene Clusters for STK19 Gene

Serine/threonine kinase 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK19 Gene

No ASD Table

Relevant External Links for STK19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STK19 Gene

mRNA expression in normal human tissues for STK19 Gene

mRNA differential expression in normal tissues according to GTEx for STK19 Gene

This gene is overexpressed in Adrenal Gland (x5.7).

Protein differential expression in normal tissues from HIPED for STK19 Gene

This gene is overexpressed in Bone (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STK19 Gene

SOURCE GeneReport for Unigene cluster for STK19 Gene Hs.654371

mRNA Expression by UniProt/SwissProt for STK19 Gene

Tissue specificity: Monocytes, hepatocytes, epithelial cells, T- and B-lymphocytes.
genes like me logo Genes that share expression patterns with STK19: view

Protein tissue co-expression partners for STK19 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for STK19 Gene

Orthologs for STK19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK19 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STK19 35
  • 85.44 (n)
  • 87.34 (a)
STK19 36
  • 82 (a)
(Canis familiaris)
Mammalia STK19 35
  • 88.98 (n)
  • 90.55 (a)
STK19 36
  • 95 (a)
(Mus musculus)
Mammalia Stk19 35
  • 82.41 (n)
  • 85.83 (a)
Stk19 16
Stk19 36
  • 86 (a)
(Pan troglodytes)
Mammalia STK19 35
  • 99.73 (n)
  • 99.45 (a)
STK19 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Stk19 35
  • 82.94 (n)
  • 85.43 (a)
(Monodelphis domestica)
Mammalia STK19 36
  • 76 (a)
(Anolis carolinensis)
Reptilia STK19 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stk19 35
  • 52.06 (n)
  • 49 (a)
Str.17311 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.22507 35
(Danio rerio)
Actinopterygii LOC100150497 35
  • 59.59 (n)
  • 55.1 (a)
stk19 36
  • 49 (a)
stk19 36
  • 49 (a)
stk19 36
  • 49 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11099 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20495 35
  • 45.48 (n)
  • 35.47 (a)
(Oryza sativa)
Liliopsida Os07g0458800 35
  • 44.17 (n)
  • 33.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for STK19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STK19 Gene

Gene Tree for STK19 (if available)
Gene Tree for STK19 (if available)

Paralogs for STK19 Gene

No data available for Paralogs for STK19 Gene

Variants for STK19 Gene

Sequence variations from dbSNP and Humsavar for STK19 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_042361 A metastatic melanoma sample
VAR_042362 -
VAR_042363 -
VAR_051387 -
rs6905149 -- 31,977,013(+) cggct(C/T)ggcat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK19 Gene

Variant ID Type Subtype PubMed ID
dgv1928e1 CNV Complex 17122850
nsv428141 CNV Gain+Loss 18775914
dgv1929e1 CNV Complex 17122850
nsv830628 CNV Loss 17160897
dgv6604n71 CNV Loss 21882294
nsv884514 CNV Loss 21882294
nsv284 CNV Loss 15895083
nsv5247 CNV Loss 18451855
dgv6605n71 CNV Loss 21882294
dgv6606n71 CNV Loss 21882294
dgv6607n71 CNV Loss 21882294
dgv6608n71 CNV Gain 21882294
esv2666636 CNV Deletion 23128226
dgv6609n71 CNV Loss 21882294
dgv6610n71 CNV Gain 21882294
dgv6611n71 CNV Gain 21882294
dgv6612n71 CNV Loss 21882294
dgv6613n71 CNV Loss 21882294
dgv6614n71 CNV Gain 21882294
dgv6615n71 CNV Gain 21882294
dgv6616n71 CNV Gain+Loss 21882294
esv28110 CNV Gain+Loss 19812545
dgv6617n71 CNV Gain+Loss 21882294
nsv10824 CNV Gain+Loss 18304495
dgv6620n71 CNV Gain 21882294
nsv819957 CNV Loss 19587683
dgv6621n71 CNV Gain 21882294
dgv6622n71 CNV Gain+Loss 21882294
nsv884617 CNV Gain 21882294
dgv20n31 CNV Duplication 19718026
nsv884626 CNV Loss 21882294
nsv884627 CNV Loss 21882294
dgv6623n71 CNV Loss 21882294
dgv6624n71 CNV Loss 21882294
dgv6625n71 CNV Gain 21882294
nsv823507 CNV Loss 20364138
dgv6626n71 CNV Gain+Loss 21882294
dgv6627n71 CNV Gain 21882294
dgv6628n71 CNV Loss 21882294
dgv6629n71 CNV Loss 21882294
nsv884657 CNV Gain 21882294
dgv6630n71 CNV Gain+Loss 21882294
dgv6631n71 CNV Loss 21882294
nsv823508 CNV Gain 20364138
nsv884663 CNV Gain 21882294
nsv884664 CNV Gain 21882294
nsv285 CNV Loss 15895083
esv2731825 CNV Deletion 23290073
nsv884665 CNV Loss 21882294

Variation tolerance for STK19 Gene

Residual Variation Intolerance Score: 18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.82; 73.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STK19 Gene

Disorders for STK19 Gene

Relevant External Links for STK19

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STK19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK19 Gene

Publications for STK19 Gene

  1. The G11 gene located in the major histocompatibility complex encodes a novel nuclear serine/threonine protein kinase. (PMID: 9812991) Gomez-Escobar N. … Campbell R.D. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex. (PMID: 8012361) Sargent C.A. … Campbell R.D. (Hum. Mol. Genet. 1994) 2 3 23
  3. Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z- RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA. (PMID: 9799600) Yang Z. … Yu C.Y. (Genomics 1998) 3 23
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. (PMID: 23263863) Li J. … Sleiman P.M. (Hum. Mol. Genet. 2013) 3

Products for STK19 Gene

Sources for STK19 Gene