Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STK17B Gene

Aliases for STK17B Gene

  • Serine/Threonine Kinase 17b 2 3
  • DRAK2 3 4 6
  • DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2 3 4
  • Death-Associated Protein Kinase-Related 2 2 3
  • EC 2.7.11.1 4 64
  • Serine/Threonine Kinase 17b (Apoptosis-Inducing) 2
  • Serine/Threonine-Protein Kinase 17B 3
  • EC 2.7.11 64

External Ids for STK17B Gene

Summaries for STK17B Gene

GeneCards Summary for STK17B Gene

STK17B (Serine/Threonine Kinase 17b) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and Sweet Taste Signaling. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is MYLK4.

UniProtKB/Swiss-Prot for STK17B Gene

  • Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK17B Gene

Genomics for STK17B Gene

Genomic Location for STK17B Gene

Start:
196,133,566 bp from pter
End:
196,176,503 bp from pter
Size:
42,938 bases
Orientation:
Minus strand

Genomic View for STK17B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STK17B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK17B Gene

Regulatory Elements for STK17B Gene

Proteins for STK17B Gene

  • Protein details for STK17B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94768-ST17B_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 17B
    Protein Accession:
    O94768
    Secondary Accessions:

    Protein attributes for STK17B Gene

    Size:
    372 amino acids
    Molecular mass:
    42344 Da
    Quaternary structure:
    • Interacts with CHP1; the interaction induces CHP1 to translocate from the Golgi to the nucleus.

    Three dimensional structures from OCA and Proteopedia for STK17B Gene

neXtProt entry for STK17B Gene

Proteomics data for STK17B Gene at MOPED

Selected DME Specific Peptides for STK17B Gene

Post-translational modifications for STK17B Gene

Other Protein References for STK17B Gene

Domains for STK17B Gene

UniProtKB/Swiss-Prot:

ST17B_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • O94768
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.:
    • O94768
genes like me logo Genes that share domains with STK17B: view

Function for STK17B Gene

Molecular function for STK17B Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.

Enzyme Numbers (IUBMB) for STK17B Gene

Gene Ontology (GO) - Molecular Function for STK17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity ISS --
GO:0004674 protein serine/threonine kinase activity IDA 9786912
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding --
GO:0005524 ATP binding IDA 9786912
genes like me logo Genes that share ontologies with STK17B: view
genes like me logo Genes that share phenotypes with STK17B: view

Animal Models for STK17B Gene

MGI Knock Outs for STK17B:

miRNA for STK17B Gene

miRTarBase miRNAs that target STK17B

No data available for Transcription Factor Targeting and HOMER Transcription for STK17B Gene

Localization for STK17B Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK17B Gene

Nucleus. Cell membrane. Endoplasmic reticulum-Golgi intermediate compartment. Note=Colocalizes with STK17B at the plasma membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK17B Gene COMPARTMENTS Subcellular localization image for STK17B gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
mitochondrion 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for STK17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9786912
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0005886 plasma membrane IEA --
GO:0015629 actin cytoskeleton IEA --
genes like me logo Genes that share ontologies with STK17B: view

Pathways for STK17B Gene

genes like me logo Genes that share pathways with STK17B: view

Pathways by source for STK17B Gene

1 Qiagen pathway for STK17B Gene
2 Cell Signaling Technology pathways for STK17B Gene

Gene Ontology (GO) - Biological Process for STK17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 9786912
GO:0006915 apoptotic process IEA --
GO:0012501 programmed cell death --
GO:0035556 intracellular signal transduction IDA 9786912
GO:0046777 protein autophosphorylation ISS --
genes like me logo Genes that share ontologies with STK17B: view

Compounds for STK17B Gene

(2) HMDB Compounds for STK17B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(1) Drugbank Compounds for STK17B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Quercetin
117-39-5 target
genes like me logo Genes that share compounds with STK17B: view

Transcripts for STK17B Gene

Unigene Clusters for STK17B Gene

Serine/threonine kinase 17b:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK17B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2:
SP3: - - - -

Relevant External Links for STK17B Gene

GeneLoc Exon Structure for
STK17B
ECgene alternative splicing isoforms for
STK17B

Expression for STK17B Gene

mRNA expression in normal human tissues for STK17B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK17B Gene

This gene is overexpressed in Whole Blood (16.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STK17B Gene

SOURCE GeneReport for Unigene cluster for STK17B Gene Hs.88297

mRNA Expression by UniProt/SwissProt for STK17B Gene

O94768-ST17B_HUMAN
Tissue specificity: Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.
genes like me logo Genes that share expressions with STK17B: view

Orthologs for STK17B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STK17B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK17B 36
  • 99.82 (n)
  • 99.46 (a)
STK17B 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STK17B 36
  • 91.04 (n)
  • 93.01 (a)
STK17B 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK17B 36
  • 93.1 (n)
  • 95.43 (a)
STK17B 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk17b 36
  • 87.28 (n)
  • 91.4 (a)
Stk17b 16
Stk17b 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK17B 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
OneToMany
-- 37
  • 69 (a)
OneToMany
-- 37
OneToMany
rat
(Rattus norvegicus)
Mammalia Stk17b 36
  • 86.34 (n)
  • 91.91 (a)
chicken
(Gallus gallus)
Aves STK17B 36
  • 72.49 (n)
  • 72.58 (a)
STK17B 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK17B 37
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 36
stk17b 36
  • 58.72 (n)
  • 57.27 (a)
stk17b 37
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Drak 36
  • 46.59 (n)
  • 43.37 (a)
Drak 37
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-22 37
  • 1 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MEK1 37
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
OneToMany
Species with no ortholog for STK17B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for STK17B Gene

ENSEMBL:
Gene Tree for STK17B (if available)
TreeFam:
Gene Tree for STK17B (if available)

Paralogs for STK17B Gene

Paralogs for STK17B Gene

genes like me logo Genes that share paralogs with STK17B: view

Variants for STK17B Gene

Sequence variations from dbSNP and Humsavar for STK17B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1054537 -- 196,139,715(-) AATAT(C/T)TCTCA synonymous-codon, reference
rs1519594 -- 196,158,324(+) TGATG(C/T)CAGTG intron-variant
rs1519595 -- 196,158,327(+) TGTCA(A/G)TGGAA intron-variant
rs1519596 -- 196,158,456(+) GAATG(C/T)TTAAC intron-variant
rs1519597 -- 196,158,485(+) TGTAT(A/G)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK17B Gene

Variant ID Type Subtype PubMed ID
nsv875691 CNV Gain 21882294
nsv875692 CNV Loss 21882294
nsv875693 CNV Loss 21882294

Relevant External Links for STK17B Gene

HapMap Linkage Disequilibrium report
STK17B

Disorders for STK17B Gene

Relevant External Links for STK17B

Genetic Association Database (GAD)
STK17B
Human Genome Epidemiology (HuGE) Navigator
STK17B
genes like me logo Genes that share disorders with STK17B: view

No data available for UniProtKB/Swiss-Prot for STK17B Gene

Publications for STK17B Gene

  1. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. (PMID: 9786912) Sanjo H. … Akira S. (J. Biol. Chem. 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger. (PMID: 11481038) Matsumoto M. … Kanazawa H. (J. Biochem. 2001) 3 23
  4. Modulation of DRAK2 autophosphorylation by antigen receptor signaling in primary lymphocytes. (PMID: 17182616) Friedrich M.L. … Walsh C.M. (J. Biol. Chem. 2007) 3 23
  5. Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. (PMID: 19638987) Doherty G.A. … Fitzgerald D.J. (Br. J. Cancer 2009) 3 23

Products for STK17B Gene

Sources for STK17B Gene

Back to Top

Content