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STK17B Gene

protein-coding   GIFtS: 64
GCID: GC02M196964

Serine/Threonine Kinase 17b

(Previous name: serine/threonine kinase 17b (apoptosis-inducing))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Threonine Kinase 17b1 2     EC 2.7.11.13 8
DRAK22 3 5     Serine/Threonine Kinase 17b (Apoptosis-Inducing)1
Death-Associated Protein Kinase-Related 21 2     Serine/Threonine-Protein Kinase 17B2
DAP Kinase-Related Apoptosis-Inducing Protein Kinase 22 3     EC 2.7.118

External Ids:    HGNC: 113961   Entrez Gene: 92622   Ensembl: ENSG000000813207   OMIM: 6047275   UniProtKB: O947683   

Export aliases for STK17B gene to outside databases

Previous GC identifers: GC02M195190 GC02M195714 GC02M197204 GC02M196827 GC02M196709 GC02M188851


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STK17B Gene:
STK17B (serine/threonine kinase 17b) is a protein-coding gene. Diseases associated with STK17B include thyroid cancer, and acute myeloid leukemia. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is DAPK2.

UniProtKB/Swiss-Prot: ST17B_HUMAN, O94768
Function: Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the STK17B gene promoter:
         RP58   C/EBPbeta   USF1   GATA-3   Nkx2-2   Evi-1   USF-1   FOXO4   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK17B promoter sequence
   Search Chromatin IP Primers for STK17B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK17B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.3   Ensembl cytogenetic band:  2q32.3   HGNC cytogenetic band: 2q33.1

STK17B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK17B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M196964:  view genomic region     (about GC identifiers)

Start:
196,998,290 bp from pter      End:
197,041,227 bp from pter
Size:
42,938 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ST17B_HUMAN, O94768 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 17B  
Size: 372 amino acids; 42344 Da
Subunit: Interacts with CHP1; the interaction induces CHP1 to translocate from the Golgi to the nucleus (By
similarity)
2 PDB 3D structures from and Proteopedia for STK17B:
3LM0 (3D)        3LM5 (3D)    

Explore the universe of human proteins at neXtProt for STK17B: NX_O94768

Explore proteomics data for STK17B at MOPED

Post-translational modifications: 

  • Autophosphorylated1
  • Ubiquitination2 at Lys24, Lys53, Lys88
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for STK17B (O94768) (see all 6)
     LSHSWLQ  EYAAGGE  IVHLDLKP  GTPEYLAPE 


    See STK17B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004217.1  
    ENSEMBL proteins: 
     ENSP00000263955   ENSP00000386853   ENSP00000475843   ENSP00000399755   ENSP00000413289  

    STK17B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine kinase 17b
    Death-associated kinase (DAPK) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O94768

    ProtoNet protein and cluster: O94768

    UniProtKB/Swiss-Prot: ST17B_HUMAN, O94768
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    STK17B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST17B_HUMAN, O94768
    Function: Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ISS--
    GO:0004674protein serine/threonine kinase activity IDA9786912
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IDA9786912
         
    STK17B for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for STK17B:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased cell death HMECs cel 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Stk17b):
     hematopoietic system  immune system 

    STK17B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Stk17btm1Hed for STK17B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STK17B
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STK17B

    miRNA
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    miRTarBase miRNAs that target STK17B:
    hsa-mir-98-5p (MIRT027654), hsa-mir-192-5p (MIRT026577)

    Block miRNA regulation of human, mouse, rat STK17B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK17B (see all 56):
    hsa-miR-219-1-3p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-607 hsa-miR-4328 hsa-miR-548k hsa-miR-106a
    SwitchGear 3'UTR luciferase reporter plasmidSTK17B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STK17B
    Predesigned siRNA for gene silencing in human, mouse, rat STK17B

    Gene Editing
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    OriGene clones in human, mouse for STK17B (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STK17B (NM_004226)
    Sino Biological Human cDNA Clone for STK17B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STK17B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK17B

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    Browse ESI BIO Cell Lines and PureStem Progenitors for STK17B 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK17B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ST17B_HUMAN, O94768: Nucleus. Cell membrane (By similarity). Endoplasmic reticulum-Golgi intermediate compartment
    (By similarity). Note=Colocalizes with STK17B at the plasma membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton2
    mitochondrion2
    plasma membrane2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9786912
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IEA--
    GO:0005886plasma membrane IEA--
    GO:0015629actin cytoskeleton IEA--

    STK17B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STK17B About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sperm Motility0.37
    2Lymphocyte Signaling
    Lymphocyte Signaling
    3Apoptosis and Autophagy
    Apoptosis and Autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STK17B
        Sperm Motility

    2 Cell Signaling Technology (CST) Pathways for STK17B
        Apoptosis and Autophagy
    Lymphocyte Signaling




    STK17B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including STK17B: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for STK17B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for STK17B (O947683 ENSP000002639554) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHP1Q996533, ENSP000003356324I2D: score=2 STRING: ENSP00000335632
    RHOVQ96L333, ENSP000002205074I2D: score=1 STRING: ENSP00000220507
    RPS24ENSP000004143214STRING: ENSP00000414321
    RAD1ENSP000003408794STRING: ENSP00000340879
    HORMAD1ENSP000003551674STRING: ENSP00000355167
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA9786912
    GO:0006915apoptotic process IEA--
    GO:0012501programmed cell death ----
    GO:0035556intracellular signal transduction IDA9786912
    GO:0046777protein autophosphorylation ISS--

    STK17B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STK17B (ST17B)

    2 HMDB Compounds for STK17B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for STK17B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Quercetin-- 117-39-5target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STK17B gene: 
    NM_004226.3  

    Unigene Cluster for STK17B:

    Serine/threonine kinase 17b
    Hs.88297  [show with all ESTs]
    Unigene Representative Sequence: NM_004226
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263955(uc002utk.3 uc010fsh.3) ENST00000409228 ENST00000606789
    ENST00000420683 ENST00000449152
    miRNA
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    Block miRNA regulation of human, mouse, rat STK17B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK17B (see all 56):
    hsa-miR-219-1-3p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-607 hsa-miR-4328 hsa-miR-548k hsa-miR-106a
    SwitchGear 3'UTR luciferase reporter plasmidSTK17B 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STK17B
      QuantiTect SYBR Green Assays in human, mouse, rat STK17B
      QuantiFast Probe-based Assays in human, mouse, rat STK17B

    Additional mRNA sequence: 

    AB011421.1 AK312865.1 BC016040.1 BC052561.1 CR542210.1 CR542225.1 

    11 DOTS entries:

    DT.410049  DT.91842412  DT.445801  DT.304766  DT.100814714  DT.100777045  DT.86859168  DT.91685262 
    DT.100814728  DT.120975763  DT.95349212 

    Selected AceView cDNA sequences (see all 173):

    CF138199 T25084 AL551557 CR593001 AA258138 AI864312 AA832365 AA370775 
    AA805077 CR607515 AW172382 CF140799 AA382203 AA740907 BP369286 CR594594 
    AA808365 AI089400 AA973829 AA283099 CN482509 AA279044 BG183084 CN481913 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for STK17B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -     -     -                                                         
    SP2:                                                                                    
    SP3:        -     -     -     -                                                         


    ECgene alternative splicing isoforms for STK17B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STK17B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATGAAAT
    STK17B Expression
    About this image


    STK17B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Hair (Integumentary System)
             Fetal Matrix Cells Hair Follicle
     
     Bone (Muscoskeletal System)
             Bone Marrow
    STK17B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STK17B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.88297

    UniProtKB/Swiss-Prot: ST17B_HUMAN, O94768
    Tissue specificity: Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal
    muscle and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including STK17B: 
              Apoptosis 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for STK17B
    OriGene qSTAR qPCR primer pairs in human, mouse for STK17B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STK17B
    QuantiTect SYBR Green Assays in human, mouse, rat STK17B
    QuantiFast Probe-based Assays in human, mouse, rat STK17B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK17B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for STK17B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk17b1 , 5 serine/threonine kinase 17b (apoptosis-inducing)1, 5 87.28(n)1
    91.4(a)1
      1 (26.99 cM)5
    982671  NM_133810.31  NP_598571.21 
     537555065 
    chicken
    (Gallus gallus)
    Aves STK17B1 serine/threonine kinase 17b 72.49(n)
    72.58(a)
      424049  NM_001031249.1  NP_001026420.1 
    lizard
    (Anolis carolinensis)
    Reptilia STK17B6
    serine/threonine kinase 17b
    72(a)
    1 ↔ 1
    GL343280.1(829587-862181)
    zebrafish
    (Danio rerio)
    Actinopterygii BC056298.12   -- 72(n)   393507  BC056298.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Drak1 Death-associated protein kinase related 46.59(n)
    43.37(a)
      32097  NM_167288.1  NP_727533.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-226
    Protein UNC-22, isoform f (unc-22) mRNA, complete ...
    1(a)
    1 → many
    IV(11972708-12011007) WBGene00006759
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MEK16
    Meiosis-specific serine/threonine protein kinase, ...
    15(a)
    1 → many
    XV(995018-996511) YOR351C


    ENSEMBL Gene Tree for STK17B (if available)
    TreeFam Gene Tree for STK17B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STK17B gene
    DAPK22  MYLK22  TTN2  STK17A2  MYLK32  OBSCN2  DAPK32  SPEG2  
    MYLK42  DAPK12  MYLK2  
    Selected SIMAP similar genes for STK17B using alignment to 6 protein entries:     ST17B_HUMAN (see all proteins) (see all similar genes):
    STK17A    DAPK3    DAPK2    RPS6KA4    DAPK1    TRIO
    TTN    KALRN    MYLK    CDK4    PRKAA1    MYLK4
    MYLK3    OBSCN    KIN27    SPEG    PRKACB    CAMK2G

    STK17B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STK17B (see all 767)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1168027381,2
    F--196997855(+) CAATCA/GTTTTT 1 -- int11Minor allele frequency- G:0.01WA 118
    rs1884553591,2
    --196998024(+) ATGCTA/GTGAAC 1 -- int10--------
    rs1927164651,2
    --196998113(+) ATAACA/TACCAT 1 -- int10--------
    rs1847152851,2
    --196998146(+) CTTAGC/TCTACA 1 -- int10--------
    rs1177680651,2
    C,F--196998161(+) GATTAT/AAAATA 1 -- int11Minor allele frequency- A:0.05EA 120
    rs722311331,2
    C--196998191(+) CATCT-/TGTG  
            
    TGTAA
    1 -- int10--------
    rs614364871,2
    C--196998194(+) CTTGT-/GTGT  
            
    AACAC
    1 -- int10--------
    rs67413071,2
    C,F,A,H--196998315(+) CTTTAT/CAGATA 1 -- ut3122Minor allele frequency- C:0.30NS EA NA WA CSA 2229
    rs1900471231,2
    --196998333(+) TAGACA/CCAAAG 1 -- ut310--------
    rs67568231,2
    C,H--196998557(+) TAAAAG/TATGGC 1 -- ut3115Minor allele frequency- T:0.00NS EA NA WA CSA 792

    HapMap Linkage Disequilibrium report for STK17B (196998290 - 197041227 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for STK17B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875692CNV Loss21882294
    nsv875693CNV Loss21882294
    nsv875691CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STK17B
    DNA2.0 Custom Variant and Variant Library Synthesis for STK17B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604727    OMIM disorders: --

    6 diseases for STK17B:    
    About MalaCards
    thyroid cancer    acute myeloid leukemia    myeloid leukemia    colorectal cancer
    thyroiditis    leukemia


    STK17B for disorders           About GeneDecksing

    Genetic Association Database (GAD): STK17B
    Human Genome Epidemiology (HuGE) Navigator: STK17B (2 documents)

    Export disorders for STK17B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STK17B gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with STK17B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. (PubMed id 9786912)1, 2, 3 Sanjo H.... Akira S. (J. Biol. Chem. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger. (PubMed id 11481038)1, 9 Matsumoto M....Kanazawa H. (J. Biochem. 2001)
    6. Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. (PubMed id 19638987)1, 9 Doherty G.A....Fitzgerald D.J. (Br. J. Cancer 2009)
    7. Modulation of DRAK2 autophosphorylation by antigen receptor signaling in primary lymphocytes. (PubMed id 17182616)1, 9 Friedrich M.L....Walsh C.M. (J. Biol. Chem. 2007)
    8. The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression. (PubMed id 23398943)1 Ye P....Gonda T.J. (Leuk. Res. 2013)
    9. DRAK2 participates in a negative feedback loop to control TGF-I^/Smads signaling by binding to type I TGF-I^ receptor. (PubMed id 23122956)1 Yang K.M....Kim S.J. (Cell Rep 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9262 HGNC: 11396 AceView: STK17B Ensembl:ENSG00000081320 euGenes: HUgn9262
    ECgene: STK17B H-InvDB: STK17B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STK17B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STK17B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STK17B gene:
    Search GeneIP for patents involving STK17B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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