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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STK17B Gene

protein-coding   GIFtS: 62
GCID: GC02M196964

Serine/Threonine Kinase 17b

(Previous name: serine/threonine kinase 17b (apoptosis-inducing))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine/Threonine Kinase 17b1 2     EC 2.7.11.13 8
Death-Associated Protein Kinase-Related 21 2     Serine/Threonine Kinase 17b (Apoptosis-Inducing)1
DRAK22 3     Serine/Threonine-Protein Kinase 17B2
DAP Kinase-Related Apoptosis-Inducing Protein Kinase 22 3     EC 2.7.118

External Ids:    HGNC: 113961   Entrez Gene: 92622   Ensembl: ENSG000000813207   OMIM: 6047275   UniProtKB: O947683   

Export aliases for STK17B gene to outside databases

Previous GC identifers: GC02M195190 GC02M195714 GC02M197204 GC02M196827 GC02M196709 GC02M188851


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for STK17B Gene: 
STK17B (serine/threonine kinase 17b) is a protein-coding gene. Diseases associated with STK17B include colorectal cancer, and thyroiditis, and among its related super-pathways are Cellular Effects of Sildenafil. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is DAPK2.

UniProtKB/Swiss-Prot: ST17B_HUMAN, O94768
Function: Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STK17B gene promoter:
         RP58   C/EBPbeta   USF1   GATA-3   Nkx2-2   Evi-1   USF-1   FOXO4   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK17B promoter sequence
   Search SABiosciences Chromatin IP Primers for STK17B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK17B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.3   Ensembl cytogenetic band:  2q32.3   HGNC cytogenetic band: 2q33.1

STK17B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK17B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M196964:  view genomic region     (about GC identifiers)

Start:
196,998,290 bp from pter      End:
197,041,227 bp from pter
Size:
42,938 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ST17B_HUMAN, O94768 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 17B  
Size: 372 amino acids; 42344 Da
Subunit: Interacts with CHP1; the interaction induces CHP1 to translocate from the Golgi to the nucleus (By
similarity)
Subcellular location: Nucleus. Cell membrane (By similarity). Endoplasmic reticulum-Golgi intermediate compartment
(By similarity). Note=Colocalizes with STK17B at the plasma membrane (By similarity)
2 PDB 3D structures from and Proteopedia for STK17B:
3LM0 (3D)        3LM5 (3D)    

Explore the universe of human proteins at neXtProt for STK17B: NX_O94768

Explore proteomics data for STK17B at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94768

  • 4/6 DME Specific Peptides for STK17B (O94768) (see all 6)
     LSHSWLQ  EYAAGGE  IVHLDLKP  GTPEYLAPE 

    STK17B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STK17B Protein Expression
    REFSEQ proteins: NP_004217.1  
    ENSEMBL proteins: 
     ENSP00000263955   ENSP00000386853   ENSP00000475843   ENSP00000399755   ENSP00000413289  

    Human Recombinant Protein Products for STK17B: 
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    Cloud-Clone Corp. Proteins for STK17B 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9786912
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IEA--
    GO:0005886plasma membrane IEA--
    GO:0015629actin cytoskeleton IEA--

    STK17B for ontologies           About GeneDecksing



    STK17B Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine kinase 17b 
    Death-associated kinase (DAPK) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O94768

    ProtoNet protein and cluster: O94768

    UniProtKB/Swiss-Prot: ST17B_HUMAN, O94768
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    STK17B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST17B_HUMAN, O94768
    Function: Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ISS--
    GO:0004674protein serine/threonine kinase activity IDA9786912
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IDA9786912
         
    STK17B for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for STK17B:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased cell death HMECs cel 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Stk17b):
     cellular  hematopoietic system  immune system 

    STK17B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Stk17btm1Hed for STK17B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for STK17B 
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    miRNA
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    hsa-miR-219-1-3p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-607 hsa-miR-4328 hsa-miR-548k hsa-miR-106a
    SwitchGear 3'UTR luciferase reporter plasmidSTK17B 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STK17B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sperm Motility0.37
    2Apoptosis and Autophagy
    Apoptosis and Autophagy
    3Lymphocyte Signaling
    Lymphocyte Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for STK17B
        Sperm Motility

    2 Cell Signaling Technology (CST) Pathways for STK17B
        Apoptosis and Autophagy
    Lymphocyte Signaling




    STK17B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STK17B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for STK17B (O947683 ENSP000002639554) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHP1Q996533, ENSP000003356324I2D: score=2 STRING: ENSP00000335632
    RHOVQ96L333I2D: score=1 
    RPS24ENSP000004143214STRING: ENSP00000414321
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA9786912
    GO:0006915apoptotic process IEA--
    GO:0007243intracellular protein kinase cascade IDA9786912
    GO:0012501programmed cell death ----
    GO:0046777protein autophosphorylation ISS--

    STK17B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STK17B (ST17B)

    2 HMDB Compounds for STK17B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for STK17B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Quercetin-- 117-39-5target--10592235

    Search CenterWatch for drugs/clinical trials and news about STK17B / ST17B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STK17B gene: 
    NM_004226.3  

    Unigene Cluster for STK17B:

    Serine/threonine kinase 17b
    Hs.88297  [show with all ESTs]
    Unigene Representative Sequence: NM_004226
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263955(uc002utk.3 uc010fsh.3) ENST00000409228 ENST00000606789
    ENST00000420683 ENST00000449152
    miRNA
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    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate STK17B (see all 56):
    hsa-miR-219-1-3p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-607 hsa-miR-4328 hsa-miR-548k hsa-miR-106a
    SwitchGear 3'UTR luciferase reporter plasmidSTK17B 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STK17B
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    Additional mRNA sequence: 

    AB011421.1 AK312865.1 BC016040.1 BC052561.1 CR542210.1 CR542225.1 

    11 DOTS entries:

    DT.410049  DT.91842412  DT.445801  DT.304766  DT.100814714  DT.100777045  DT.86859168  DT.91685262 
    DT.100814728  DT.120975763  DT.95349212 

    24/173 AceView cDNA sequences (see all 173):

    AW172382 AA808365 AL551557 AI089400 CR593001 AA832365 AI864312 AA283099 
    CF140799 BP369286 CF138199 AA973829 CR607515 AA382203 CR594594 AA370775 
    T25084 AA258138 AA805077 AA740907 AA808007 CR542210 AA872988 BG340497 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for STK17B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -     -     -                                                         
    SP2:                                                                                    
    SP3:        -     -     -     -                                                         


    ECgene alternative splicing isoforms for STK17B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STK17B expression in normal human tissues (normalized intensities)      STK17B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATGAAAT
    STK17B Expression
    About this image


    STK17B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             LYMPH NODE   
     
     Brain (Nervous System)
             Cerebellum

    See STK17B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STK17B

    SOURCE GeneReport for Unigene cluster: Hs.88297

    UniProtKB/Swiss-Prot: ST17B_HUMAN, O94768
    Tissue specificity: Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal
    muscle and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including STK17B: 
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK17B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for STK17B gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk17b1 , 5 serine/threonine kinase 17b (apoptosis-inducing)1, 5 87.28(n)1
    91.4(a)1
      1 (26.99 cM)5
    982671  NM_133810.31  NP_598571.21 
     537555065 
    chicken
    (Gallus gallus)
    Aves STK17B1 serine/threonine kinase 17b 72.49(n)
    72.58(a)
      424049  NM_001031249.1  NP_001026420.1 
    lizard
    (Anolis carolinensis)
    Reptilia STK17B6
    Uncharacterized protein
    72(a)
    1 ↔ 1
    GL343280.1(829587-862181)
    zebrafish
    (Danio rerio)
    Actinopterygii BC056298.12   -- 72(n)   393507  BC056298.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Drak6
    Death-associated protein kinase related
    16(a)
    1 → many
    X(11387203-11449079)


    ENSEMBL Gene Tree for STK17B (if available)
    TreeFam Gene Tree for STK17B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STK17B gene
    DAPK22  MYLK22  TTN2  MYLK32  STK17A2  DAPK32  SPEG2  MYLK42  
    DAPK12  MYLK2  
    18/33 SIMAP similar genes for STK17B using alignment to 5 protein entries:     ST17B_HUMAN (see all proteins) (see all similar genes):
    STK17A    DAPK3    DAPK2    DAPK1    TRIO    TTN
    KALRN    MYLK    CDK4    PRKAA1    MYLK4    MYLK3
    OBSCN    KIN27    SPEG    PRKACB    CAMK2G    CAMK1D

    STK17B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/767 SNPs in STK17B are shown (see all 767)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1168027381,2
    F--196997855(+) CAATCA/GTTTTT 1 -- int11Minor allele frequency- G:0.01WA 118
    rs1884553591,2
    --196998024(+) ATGCTA/GTGAAC 1 -- int10--------
    rs1927164651,2
    --196998113(+) ATAACA/TACCAT 1 -- int10--------
    rs1847152851,2
    --196998146(+) CTTAGC/TCTACA 1 -- int10--------
    rs1177680651,2
    C,F--196998161(+) GATTAT/AAAATA 1 -- int11Minor allele frequency- A:0.05EA 120
    rs722311331,2
    C--196998191(+) CATCT-/TGTG  
            
    TGTAA
    1 -- int10--------
    rs614364871,2
    C--196998194(+) CTTGT-/GTGT  
            
    AACAC
    1 -- int10--------
    rs67413071,2
    C,F,A,H--196998315(+) CTTTAT/CAGATA 1 -- ut3122Minor allele frequency- C:0.30NS EA NA WA CSA 2229
    rs1900471231,2
    --196998333(+) TAGACA/CCAAAG 1 -- ut310--------
    rs67568231,2
    C,H--196998557(+) TAAAAG/TATGGC 1 -- ut3115Minor allele frequency- T:0.00NS EA NA WA CSA 792

    HapMap Linkage Disequilibrium report for STK17B (196998290 - 197041227 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for STK17B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv875692CNV Loss21882294
    nsv875693CNV Loss21882294
    nsv875691CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604727    OMIM disorders: --

    2 diseases for STK17B:    About MalaCards
    colorectal cancer    thyroiditis


    STK17B for disorders           About GeneDecksing

    Genetic Association Database (GAD): STK17B
    Human Genome Epidemiology (HuGE) Navigator: STK17B (2 documents)

    Export disorders for STK17B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STK17B gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with STK17B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. (PubMed id 9786912)1, 2, 3 Sanjo H.... Akira S. (1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The variant rs1867277 in FOXE1 gene confers thyroid c ancer susceptibility through the recruitment of USF1/USF2 transcription factors . (PubMed id 19730683)1, 4 Landa I....Robledo M. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger. (PubMed id 11481038)1, 9 Matsumoto M....Kanazawa H. (2001)
    6. Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. (PubMed id 19638987)1, 9 Doherty G.A....Fitzgerald D.J. (2009)
    7. Modulation of DRAK2 autophosphorylation by antigen receptor signaling in primary lymphocytes. (PubMed id 17182616)1, 9 Friedrich M.L....Walsh C.M. (2007)
    8. The MYB oncogene can suppress apoptosis in acute myelo id leukemia cells by transcriptional repression of DRAK2 expression. (PubMed id 23398943)1 Ye P....Gonda T.J. (2013)
    9. DRAK2 participates in a negative feedback loop to cont rol TGF-b/Smads signaling by binding to type I TGF-b receptor. (PubMed id 23122956)1 Yang K.M....Kim S.J. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9262 HGNC: 11396 AceView: STK17B Ensembl:ENSG00000081320 euGenes: HUgn9262
    ECgene: STK17B H-InvDB: STK17B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STK17B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STK17B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STK17B gene:
    Search GeneIP for patents involving STK17B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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