Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STK17B Gene

Aliases for STK17B Gene

  • Serine/Threonine Kinase 17b 2 3 5
  • DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2 3 4
  • Death-Associated Protein Kinase-Related 2 2 3
  • EC 2.7.11.1 4 61
  • DRAK2 3 4
  • Serine/Threonine Kinase 17b (Apoptosis-Inducing) 2
  • Serine/Threonine-Protein Kinase 17B 3
  • EC 2.7.11 61

External Ids for STK17B Gene

Previous GeneCards Identifiers for STK17B Gene

  • GC02M195190
  • GC02M195714
  • GC02M196964
  • GC02M197204
  • GC02M196827
  • GC02M196709
  • GC02M188851

Summaries for STK17B Gene

GeneCards Summary for STK17B Gene

STK17B (Serine/Threonine Kinase 17b) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and NF-kappaB Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK17A.

UniProtKB/Swiss-Prot for STK17B Gene

  • Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK17B Gene

Genomics for STK17B Gene

Regulatory Elements for STK17B Gene

Enhancers for STK17B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F196210 0.9 FANTOM5 Ensembl ENCODE 37.9 -36.1 -36098 4.4 TBP PKNOX1 ATF1 BMI1 RAD21 CBX5 ETV6 CREM CBFB CEBPB STK17B LOC101927482 GC02M196143
GH02F196237 1.1 FANTOM5 Ensembl ENCODE 37.6 -68.1 -68098 14.0 HDGF PKNOX1 ATF1 YY1 CBX5 FOS JUNB TBX21 MAFF SMARCA4 STK17B CCDC150 ENSG00000223466 DNAH7 GC02M196143
GH02F196228 1.4 FANTOM5 Ensembl ENCODE 25.9 -55.8 -55798 7.4 PKNOX1 WRNIP1 SIN3A RAD21 RCOR1 FOS JUNB ZHX2 TBX21 ZNF217 STK17B ENSG00000223466 GC02M196143
GH02F196204 1 FANTOM5 Ensembl 25.4 -29.3 -29298 2.8 ZNF146 CEBPG RELA ZNF316 CTBP1 ZNF366 POLR2A EED ETV6 MAFK STK17B LOC101927482 GC02M196143
GH02F196224 0.9 Ensembl ENCODE 18.9 -49.0 -48999 2.6 RFX1 L3MBTL2 FEZF1 ZIC2 ZNF843 ZNF335 JUND FOXP2 ZNF600 ZSCAN29 STK17B GC02M196143
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around STK17B on UCSC Golden Path with GeneCards custom track

Promoters for STK17B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001831037 403 201 PKNOX1 TBL1XR1 BMI1 RELA EGR1 POLR2A EED ETV6 CREM MTA2

Genomic Location for STK17B Gene

Chromosome:
2
Start:
196,133,566 bp from pter
End:
196,176,503 bp from pter
Size:
42,938 bases
Orientation:
Minus strand

Genomic View for STK17B Gene

Genes around STK17B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK17B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK17B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK17B Gene

Proteins for STK17B Gene

  • Protein details for STK17B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94768-ST17B_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 17B
    Protein Accession:
    O94768

    Protein attributes for STK17B Gene

    Size:
    372 amino acids
    Molecular mass:
    42344 Da
    Quaternary structure:
    • Interacts with CHP1; the interaction induces CHP1 to translocate from the Golgi to the nucleus.

    Three dimensional structures from OCA and Proteopedia for STK17B Gene

neXtProt entry for STK17B Gene

Selected DME Specific Peptides for STK17B Gene

Post-translational modifications for STK17B Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STK17B (DRAK2)
  • Abcam antibodies for STK17B

Domains & Families for STK17B Gene

Gene Families for STK17B Gene

Protein Domains for STK17B Gene

Graphical View of Domain Structure for InterPro Entry

O94768

UniProtKB/Swiss-Prot:

ST17B_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
genes like me logo Genes that share domains with STK17B: view

Function for STK17B Gene

Molecular function for STK17B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.

Enzyme Numbers (IUBMB) for STK17B Gene

Gene Ontology (GO) - Molecular Function for STK17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,ISS --
GO:0004674 protein serine/threonine kinase activity IDA 9786912
GO:0005524 ATP binding IEA,IDA 9786912
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with STK17B: view
genes like me logo Genes that share phenotypes with STK17B: view

Animal Models for STK17B Gene

MGI Knock Outs for STK17B:

Animal Model Products

  • Taconic Biosciences Mouse Models for STK17B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK17B Gene

Localization for STK17B Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK17B Gene

Nucleus. Cell membrane. Endoplasmic reticulum-Golgi intermediate compartment. Note=Colocalizes with STK17B at the plasma membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK17B Gene COMPARTMENTS Subcellular localization image for STK17B gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 4
cytoskeleton 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for STK17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9786912
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0005886 plasma membrane IEA --
GO:0015629 actin cytoskeleton IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with STK17B: view

Pathways & Interactions for STK17B Gene

genes like me logo Genes that share pathways with STK17B: view

Pathways by source for STK17B Gene

2 Cell Signaling Technology pathways for STK17B Gene
1 Qiagen pathway for STK17B Gene

Gene Ontology (GO) - Biological Process for STK17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 9786912
GO:0006915 apoptotic process IEA --
GO:0012501 programmed cell death IEA --
GO:0016310 phosphorylation IEA --
GO:0035556 intracellular signal transduction IDA 9786912
genes like me logo Genes that share ontologies with STK17B: view

No data available for SIGNOR curated interactions for STK17B Gene

Drugs & Compounds for STK17B Gene

(2) Drugs for STK17B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Quercetin Experimental Nutra Target Antitumor agent 40

(1) Additional Compounds for STK17B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK17B: view

Transcripts for STK17B Gene

Unigene Clusters for STK17B Gene

Serine/threonine kinase 17b:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK17B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2:
SP3: - - - -

Relevant External Links for STK17B Gene

GeneLoc Exon Structure for
STK17B
ECgene alternative splicing isoforms for
STK17B

Expression for STK17B Gene

mRNA expression in normal human tissues for STK17B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK17B Gene

This gene is overexpressed in Whole Blood (x16.4).

Protein differential expression in normal tissues from HIPED for STK17B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.7), CD4 Tcells (14.7), and CD8 Tcells (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STK17B Gene



Protein tissue co-expression partners for STK17B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STK17B Gene:

STK17B

SOURCE GeneReport for Unigene cluster for STK17B Gene:

Hs.88297

mRNA Expression by UniProt/SwissProt for STK17B Gene:

O94768-ST17B_HUMAN
Tissue specificity: Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.
genes like me logo Genes that share expression patterns with STK17B: view

Primer Products

Orthologs for STK17B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STK17B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK17B 34 35
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia STK17B 34 35
  • 93.1 (n)
cow
(Bos Taurus)
Mammalia STK17B 34 35
  • 91.04 (n)
mouse
(Mus musculus)
Mammalia Stk17b 34 16 35
  • 87.28 (n)
oppossum
(Monodelphis domestica)
Mammalia STK17B 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk17b 34
  • 86.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
OneToMany
-- 35
OneToMany
-- 35
OneToMany
chicken
(Gallus gallus)
Aves STK17B 34 35
  • 72.49 (n)
lizard
(Anolis carolinensis)
Reptilia STK17B 35
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii stk17b 34 35
  • 58.72 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Drak 34 35
  • 46.59 (n)
worm
(Caenorhabditis elegans)
Secernentea unc-22 35
  • 1 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MEK1 35
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for STK17B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for STK17B Gene

ENSEMBL:
Gene Tree for STK17B (if available)
TreeFam:
Gene Tree for STK17B (if available)

Paralogs for STK17B Gene

Variants for STK17B Gene

Sequence variations from dbSNP and Humsavar for STK17B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10165580 -- 196,152,635(+) aataa(C/T)agtca intron-variant
rs10167112 -- 196,144,193(+) AAAAA(A/T)TTAAA intron-variant
rs10167113 -- 196,144,196(+) AAATT(A/T)AAAAA intron-variant
rs10167438 -- 196,144,498(+) aaaaa(A/C)aaaaa intron-variant
rs10177341 -- 196,160,911(+) ACTAA(C/T)ATCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK17B Gene

Variant ID Type Subtype PubMed ID
esv2763057 CNV loss 21179565
esv3355150 CNV insertion 20981092
esv3593879 CNV loss 21293372
nsv1005678 CNV gain 25217958
nsv584151 CNV loss 21841781

Variation tolerance for STK17B Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK17B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK17B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK17B Gene

Disorders for STK17B Gene

Relevant External Links for STK17B

Genetic Association Database (GAD)
STK17B
Human Genome Epidemiology (HuGE) Navigator
STK17B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK17B

No disorders were found for STK17B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK17B Gene

Publications for STK17B Gene

  1. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. (PMID: 9786912) Sanjo H. … Akira S. (J. Biol. Chem. 1998) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. (PMID: 19638987) Doherty G.A. … Fitzgerald D.J. (Br. J. Cancer 2009) 3 22 64
  4. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PMID: 19730683) Landa I. … Robledo M. (PLoS Genet. 2009) 3 46 64
  5. Modulation of DRAK2 autophosphorylation by antigen receptor signaling in primary lymphocytes. (PMID: 17182616) Friedrich M.L. … Walsh C.M. (J. Biol. Chem. 2007) 3 22 64

Products for STK17B Gene

Sources for STK17B Gene

Content
Loading form....