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Aliases for STK17A Gene

Aliases for STK17A Gene

  • Serine/Threonine Kinase 17a 2 3 5
  • DAP Kinase-Related Apoptosis-Inducing Protein Kinase 1 3 4
  • Serine/Threonine Kinase 17a (Apoptosis-Inducing) 2 3
  • Death-Associated Protein Kinase-Related 1 2 3
  • EC 2.7.11.1 4 63
  • DRAK1 3 4

External Ids for STK17A Gene

Previous GeneCards Identifiers for STK17A Gene

  • GC07P043269
  • GC07P043363
  • GC07P043395
  • GC07P043589
  • GC07P043507

Summaries for STK17A Gene

Entrez Gene Summary for STK17A Gene

  • This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK17A Gene

STK17A (Serine/Threonine Kinase 17a) is a Protein Coding gene. Diseases associated with STK17A include cisplatin toxicity. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MYLK4.

UniProtKB/Swiss-Prot for STK17A Gene

  • Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK17A Gene

Genomics for STK17A Gene

Regulatory Elements for STK17A Gene

Genomic Location for STK17A Gene

Chromosome:
7
Start:
43,582,758 bp from pter
End:
43,627,379 bp from pter
Size:
44,622 bases
Orientation:
Plus strand

Genomic View for STK17A Gene

Genes around STK17A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK17A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK17A Gene

Proteins for STK17A Gene

  • Protein details for STK17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UEE5-ST17A_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 17A
    Protein Accession:
    Q9UEE5
    Secondary Accessions:
    • A4D1V6
    • Q8IVC8

    Protein attributes for STK17A Gene

    Size:
    414 amino acids
    Molecular mass:
    46558 Da
    Quaternary structure:
    No Data Available

neXtProt entry for STK17A Gene

Proteomics data for STK17A Gene at MOPED

Selected DME Specific Peptides for STK17A Gene

Post-translational modifications for STK17A Gene

Other Protein References for STK17A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for STK17A Gene

Gene Families for STK17A Gene

Suggested Antigen Peptide Sequences for STK17A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UEE5

UniProtKB/Swiss-Prot:

ST17A_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
genes like me logo Genes that share domains with STK17A: view

Function for STK17A Gene

Molecular function for STK17A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by thiazolidinedione-type compounds: inhibited by furan- and pyridone- thiazolidinediones.
UniProtKB/Swiss-Prot Function:
Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.
UniProtKB/Swiss-Prot Induction:
Directly regulated by p53/TP53: induced following cisplatin treatment in a p53/TP53-dependent manner. p53/TP53 activates expression by directly binding to its regulatory regions.

Enzyme Numbers (IUBMB) for STK17A Gene

Gene Ontology (GO) - Molecular Function for STK17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA,IDA 9786912
genes like me logo Genes that share ontologies with STK17A: view
genes like me logo Genes that share phenotypes with STK17A: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK17A Gene

Localization for STK17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK17A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK17A Gene COMPARTMENTS Subcellular localization image for STK17A gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for STK17A Gene

Pathways & Interactions for STK17A Gene

SuperPathways for STK17A Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK17A: view

Pathways by source for STK17A Gene

1 Qiagen pathway for STK17A Gene

Interacting Proteins for STK17A Gene

SIGNOR curated interactions for STK17A Gene

Activates:

Gene Ontology (GO) - Biological Process for STK17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 9786912
GO:0006915 apoptotic process IEA --
GO:0043065 positive regulation of apoptotic process IMP 21489989
GO:2000271 positive regulation of fibroblast apoptotic process IMP 9786912
GO:2000377 regulation of reactive oxygen species metabolic process IMP 21489989
genes like me logo Genes that share ontologies with STK17A: view

Drugs & Compounds for STK17A Gene

(3) Drugs for STK17A Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for STK17A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK17A: view

Transcripts for STK17A Gene

mRNA/cDNA for STK17A Gene

Unigene Clusters for STK17A Gene

Serine/threonine kinase 17a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK17A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2:

Relevant External Links for STK17A Gene

GeneLoc Exon Structure for
STK17A
ECgene alternative splicing isoforms for
STK17A

Expression for STK17A Gene

mRNA expression in normal human tissues for STK17A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK17A Gene

This gene is overexpressed in Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for STK17A Gene

This gene is overexpressed in NK cells (29.5), Spleen (15.1), Placenta (11.6), and CD8 Tcells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STK17A Gene



SOURCE GeneReport for Unigene cluster for STK17A Gene Hs.709489

mRNA Expression by UniProt/SwissProt for STK17A Gene

Q9UEE5-ST17A_HUMAN
Tissue specificity: Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with STK17A: view

Protein tissue co-expression partners for STK17A Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for STK17A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK17A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK17A 35
  • 99.76 (n)
  • 99.52 (a)
STK17A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STK17A 36
  • 86 (a)
OneToOne
STK17A 35
  • 88.49 (n)
  • 89.13 (a)
dog
(Canis familiaris)
Mammalia STK17A 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK17A 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK17A 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK17A 36
  • 77 (a)
OneToOne
STK17A 35
  • 76.07 (n)
  • 79.35 (a)
lizard
(Anolis carolinensis)
Reptilia STK17A 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.27469 35
tropical clawed frog
(Silurana tropicalis)
Amphibia stk17a 35
  • 68.56 (n)
  • 66.91 (a)
Str.7458 35
zebrafish
(Danio rerio)
Actinopterygii stk17a 36
  • 70 (a)
OneToOne
-- 35
stk17a 35
  • 64.63 (n)
  • 73.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Drak 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-22 36
  • 2 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MEK1 36
  • 15 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.41 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for STK17A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK17A Gene

ENSEMBL:
Gene Tree for STK17A (if available)
TreeFam:
Gene Tree for STK17A (if available)

Paralogs for STK17A Gene

Paralogs for STK17A Gene

genes like me logo Genes that share paralogs with STK17A: view

Variants for STK17A Gene

Sequence variations from dbSNP and Humsavar for STK17A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_019991 -
VAR_032823 -
rs56286238 - 43,596,072(+) CATGA(A/C)GTTTA reference, missense
VAR_041146 -
rs2330875 -- 43,585,513(+) AAAGC(A/T)GCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK17A Gene

Variant ID Type Subtype PubMed ID
nsv518728 CNV Loss 19592680
esv2665229 CNV Deletion 23128226
esv22147 CNV Loss 19812545
nsv819718 CNV Loss 19587683

Variation tolerance for STK17A Gene

Residual Variation Intolerance Score: 51.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK17A Gene

HapMap Linkage Disequilibrium report
STK17A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK17A Gene

Disorders for STK17A Gene

MalaCards: The human disease database

(1) MalaCards diseases for STK17A Gene - From: GeneCards

Disorder Aliases PubMed IDs
cisplatin toxicity
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for STK17A

Genetic Association Database (GAD)
STK17A
Human Genome Epidemiology (HuGE) Navigator
STK17A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK17A
genes like me logo Genes that share disorders with STK17A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK17A Gene

Publications for STK17A Gene

  1. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. (PMID: 9786912) Sanjo H. … Akira S. (J. Biol. Chem. 1998) 2 3 4 67
  2. The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-I^1 production and FcRL4 expression. (PMID: 24162774) Jelicic K. … Fauci A.S. (Nat. Immunol. 2013) 3
  3. Serine/Threonine Kinase 17A Is a Novel Candidate for Therapeutic Targeting in Glioblastoma. (PMID: 24312360) Mao P. … Spinella M.J. (PLoS ONE 2013) 3
  4. Polymorphisms in STK17A gene are associated with systemic lupus erythematosus and its clinical manifestations. (PMID: 23860322) da Silva Fonseca A.M. … Sandrin-Garcia P. (Gene 2013) 3
  5. Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells. (PMID: 21489989) Mao P. … Spinella M.J. (J. Biol. Chem. 2011) 3

Products for STK17A Gene

Sources for STK17A Gene

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