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STK17A Gene

protein-coding   GIFtS: 58
GCID: GC07P043589

Serine/Threonine Kinase 17a

(Previous name: serine/threonine kinase 17a (apoptosis-inducing))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Threonine Kinase 17a1 2     DAP Kinase-Related Apoptosis-Inducing Protein Kinase 12 3
DRAK12 3 5     EC 2.7.11.13 8
Serine/Threonine Kinase 17a (Apoptosis-Inducing)1 2     Serine/Threonine-Protein Kinase 17A2
Death-Associated Protein Kinase-Related 11 2     

External Ids:    HGNC: 113951   Entrez Gene: 92632   Ensembl: ENSG000001645437   OMIM: 6047265   UniProtKB: Q9UEE53   

Export aliases for STK17A gene to outside databases

Previous GC identifers: GC07P043269 GC07P043363 GC07P043395 GC07P043507


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STK17A Gene:
This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an
autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity.
(provided by RefSeq, Jul 2008)

GeneCards Summary for STK17A Gene:
STK17A (serine/threonine kinase 17a) is a protein-coding gene. Diseases associated with STK17A include testicular cancer, and testicular germ cell tumor. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is STK17B.

UniProtKB/Swiss-Prot: ST17A_HUMAN, Q9UEE5
Function: Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the STK17A gene promoter:
         AML1a   C/EBPalpha   FOXC1   FOXJ2 (long isoform)   FOXO4   FOXO1a   FOXJ2   Hlf   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): STK17A promoter sequence
   Search Chromatin IP Primers for STK17A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK17A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p13

STK17A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK17A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P043589:  view genomic region     (about GC identifiers)

Start:
43,622,357 bp from pter      End:
43,666,978 bp from pter
Size:
44,622 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 43,662,202-43,706,491     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ST17A_HUMAN, Q9UEE5 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 17A  
Size: 414 amino acids; 46558 Da
Secondary accessions: A4D1V6 Q8IVC8

Explore the universe of human proteins at neXtProt for STK17A: NX_Q9UEE5

Explore proteomics data for STK17A at MOPED

Post-translational modifications: 

  • Autophosphorylated1
  • Ubiquitination2 at Lys188, Lys317
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for STK17A (Q9UEE5)
     EYAAGGE  ELREIMGTPEY  ELGRGKFAVVR 


    See STK17A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004751.2  
    ENSEMBL proteins: 
     ENSP00000319192  

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    Cloud-Clone Corp. Proteins for STK17A

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    STK17A Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine kinase 17a
    Death-associated kinase (DAPK) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9UEE5

    ProtoNet protein and cluster: Q9UEE5

    UniProtKB/Swiss-Prot: ST17A_HUMAN, Q9UEE5
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    STK17A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST17A_HUMAN, Q9UEE5
    Function: Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by thiazolidinedione-type compounds: inhibited by furan- and pyridone-
    thiazolidinediones
    Induction: Directly regulated by p53/TP53: induced following cisplatin treatment in a p53/TP53-dependent manner.
    p53/TP53 activates expression by directly binding to its regulatory regions

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA9786912
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IDA9786912
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    STK17A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for STK17A:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STK17A
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    miRNA
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    Block miRNA regulation of human, mouse, rat STK17A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK17A (see all 18):
    hsa-miR-1271 hsa-miR-340 hsa-miR-890 hsa-miR-383 hsa-miR-520g hsa-miR-3143 hsa-miR-96 hsa-miR-384
    SwitchGear 3'UTR luciferase reporter plasmidSTK17A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STK17A
    Predesigned siRNA for gene silencing in human, mouse, rat STK17A

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for STK17A

    Clone
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    GenScript: all cDNA clones in your preferred vector: STK17A (NM_004760)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STK17A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK17A

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for STK17A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK17A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ST17A_HUMAN, Q9UEE5: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9786912

    STK17A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STK17A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sperm Motility0.37

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STK17A
        Sperm Motility


        Pathway & Disease-focused RT2 Profiler PCR Array including STK17A: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for STK17A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for STK17A (ENSP000003191924) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC3ENSP000003029674STRING: ENSP00000302967
    RHOVENSP000002205074STRING: ENSP00000220507
    RAD1ENSP000003408794STRING: ENSP00000340879
    UBCENSP000003448184STRING: ENSP00000344818
    MAP2K2ENSP000002629484STRING: ENSP00000262948
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA9786912
    GO:0006915apoptotic process IEA--
    GO:0035556intracellular signal transduction IDA9786912
    GO:0043065positive regulation of apoptotic process IMP--
    GO:2000271positive regulation of fibroblast apoptotic process IMP9786912

    STK17A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STK17A (ST17A)

    2 HMDB Compounds for STK17A    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 Novoseek inferred chemical compound relationships for STK17A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 44.4 2 11279167 (1), 10629061 (1)
    serine 30.9 2 11279167 (1), 10629061 (1)



    STK17A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STK17A gene: 
    NM_004760.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462448 ENST00000319357(uc003tih.3) ENST00000474211
    miRNA
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    Block miRNA regulation of human, mouse, rat STK17A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK17A (see all 18):
    hsa-miR-1271 hsa-miR-340 hsa-miR-890 hsa-miR-383 hsa-miR-520g hsa-miR-3143 hsa-miR-96 hsa-miR-384
    SwitchGear 3'UTR luciferase reporter plasmidSTK17A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STK17A
    Predesigned siRNA for gene silencing in human, mouse, rat STK17A
    Clone
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    OriGene clones in human, mouse for STK17A (see all 6)
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    GenScript: all cDNA clones in your preferred vector: STK17A (NM_004760)
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    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STK17A
    OriGene qSTAR qPCR primer pairs in human, mouse for STK17A
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat STK17A
      QuantiTect SYBR Green Assays in human, mouse, rat STK17A
      QuantiFast Probe-based Assays in human, mouse, rat STK17A

    Selected AceView cDNA sequences (see all 232):

    AA610593 AI140803 BF057275 AA453754 AA714500 CF242838 AA332079 AA228041 
    BG620920 CR597510 AW337444 AW593835 AI073365 AI335945 AW236955 AI142499 
    BF589242 CB528466 AA455909 CR599395 BM128613 AA234089 CR623604 AI479282 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for STK17A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:                          -                     
    SP2:                                                


    ECgene alternative splicing isoforms for STK17A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STK17A expression in normal human tissues (normalized intensities)      STK17A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTGGAAGT
    STK17A Expression
    About this image


    STK17A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Thymus
    STK17A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STK17A Protein Expression

    UniProtKB/Swiss-Prot: ST17A_HUMAN, Q9UEE5
    Tissue specificity: Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and
    pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including STK17A: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat STK17A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK17A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STK17A gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia STK17A6
    serine/threonine kinase 17a
    92(a)
    1 ↔ 1
    18(6590105-6626284)
    chicken
    (Gallus gallus)
    Aves STK17A1 serine/threonine kinase 17a 76.07(n)
    79.35(a)
      420775  NM_001030995.1  NP_001026166.1 
    lizard
    (Anolis carolinensis)
    Reptilia STK17A6
    serine/threonine kinase 17a
    74(a)
    1 ↔ 1
    6(50814562-50846178)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.274692 Xenopus laevis transcribed sequence with weak similarity more 77.18(n)    CA792591.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CA471289.12   -- 73.84(n)   334119  CA471289.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Drak6
    Death-associated protein kinase related
    20(a)
    1 → many
    X(11387203-11449079)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-226
    Protein UNC-22, isoform f (unc-22) mRNA, complete ...
    2(a)
    1 → many
    IV(11972708-12011007) WBGene00006759
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MEK16
    Meiosis-specific serine/threonine protein kinase, ...
    15(a)
    1 → many
    XV(995018-996511) YOR351C
    rice
    (Oryza sativa)
    Liliopsida NM_197303.12   -- 69.72(n)    NM_197303.1 


    ENSEMBL Gene Tree for STK17A (if available)
    TreeFam Gene Tree for STK17A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STK17A gene
    STK17B2  DAPK22  MYLK22  TTN2  MYLK32  OBSCN2  DAPK32  SPEG2  
    MYLK42  DAPK12  MYLK2  
    Selected SIMAP similar genes for STK17A using alignment to 3 protein entries:     ST17A_HUMAN (see all proteins) (see all similar genes):
    STK17B    DAPK1    DAPK2    DAPK3    NUAK1    BRSK2
    MYLK    KALRN    CDK4    MYLK3    TRIO    TTN
    MKNK1    PHKG2    MARK2    PRKAA1    PRKD1    Par1b

    STK17A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STK17A (see all 904)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs731027181,2
    C--43620786(+) CCCATA/GATTCT 1 -- us2k14Minor allele frequency- G:0.09NA WA EA 360
    rs1145147941,2
    C--43620959(+) TGGATA/CTTCTG 1 -- us2k10--------
    rs1179064141,2
    C,F--43621044(+) ACATGG/TTGTAT 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1462149701,2
    --43621059(+) TATTAA/TATGGG 1 -- us2k10--------
    rs1138510751,2
    F--43621188(+) CTCTTC/TGGAGT 1 -- us2k12Minor allele frequency- T:0.07CSA WA 120
    rs1407139611,2
    C--43621252(+) TCCAA-/TTTTTT 1 -- us2k10--------
    rs1389424091,2
    --43621324(+) CCATGA/GCTTTA 1 -- us2k10--------
    rs770060021,2
    C--43621348(+) CCTCAT/CGGGAA 1 -- us2k12Minor allele frequency- C:0.09CSA WA 120
    rs747686971,2
    C,F--43621500(+) TGCCAG/TAAGCA 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs781495881,2
    F--43621512(+) AACTCC/TACTGA 1 -- us2k11Minor allele frequency- T:0.03EA 120

    HapMap Linkage Disequilibrium report for STK17A (43622357 - 43666978 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for STK17A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665229CNV Deletion23128226
    esv22147CNV Loss19812545
    nsv819718CNV Loss19587683
    nsv518728CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604726    OMIM disorders: --

    10 diseases for STK17A:    About MalaCards
    testicular cancer    testicular germ cell tumor    narcolepsy    germ cell tumors
    retinoblastoma    thyroid cancer    hypertension    pancreatic cancer
    pancreatitis    thyroiditis


    STK17A for disorders           About GeneDecksing

    Genetic Association Database (GAD): STK17A
    Human Genome Epidemiology (HuGE) Navigator: STK17A (3 documents)

    Export disorders for STK17A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STK17A gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with STK17A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. (PubMed id 9786912)1, 2, 3 Sanjo H.... Akira S. (J. Biol. Chem. 1998)
    2. Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells. (PubMed id 21489989)1, 2 Mao P....Spinella M.J. (J. Biol. Chem. 2011)
    3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    4. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    8. Polymorphisms in STK17A gene are associated with systemic lupus erythematosus and its clinical manifestations. (PubMed id 23860322)1 da Silva Fonseca A.M....Sandrin-Garcia P. (Gene 2013)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9263 HGNC: 11395 AceView: STK17A Ensembl:ENSG00000164543 euGenes: HUgn9263
    ECgene: STK17A H-InvDB: STK17A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STK17A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STK17A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STK17A gene:
    Search GeneIP for patents involving STK17A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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