STK17A Gene
protein-coding GIFtS: 57
GCID: GC07P043589
|
|
serine/threonine kinase 17a(Previous name: serine/threonine kinase 17a (apoptosis-inducing) )
| |
Aliases
for STK17A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine/Threonine Kinase 17a1 2 | | EC 2.7.11.13 8 | | DRAK11 2 3 | | Death-Associated Protein Kinase-Related 12 | | Serine/Threonine Kinase 17a (Apoptosis-Inducing)1 2 | | Serine/Threonine-Protein Kinase 17A2 | | DAP Kinase-Related Apoptosis-Inducing Protein Kinase 12 3 | | |
Export aliases for STK17A gene to outside databasesPrevious GC identifers: GC07P043269 GC07P043363 GC07P043395 GC07P043507 |
Summaries
for STK17A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for STK17A:
This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes anautophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ST17A_HUMAN, Q9UEE5Function: Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species
|
Genomic Views
for STK17A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STK17A gene promoter:
AML1a C/EBPalpha FOXC1 FOXJ2 (long isoform) FOXO4 FOXO1a FOXJ2 Hlf FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for STK17A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK17A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p13 Ensembl cytogenetic band: 7p13 HGNC cytogenetic band: 7p13STK17A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P043589: view genomic region
(about GC identifiers)
Start:
|
43,622,357 bp from pter |
End:
|
43,666,978 bp from pter |
Size:
|
44,622 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 43,662,202-43,706,491 |
|
Proteins
for STK17A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ST17A_HUMAN, Q9UEE5 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase 17A Size: 414 amino acids; 46558 Da
Subcellular location: Nucleus
Secondary accessions: A4D1V6 Q8IVC8Explore the universe of human proteins at neXtProt for STK17A: NX_Q9UEE5
Post-translational modifications:
Autophosphorylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UEE5
3 DME Specific Peptides for STK17A (Q9UEE5)
STK17A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004751.2
ENSEMBL proteins: ENSP00000319192
Human Recombinant Protein Products for STK17A:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
STK17A for ontologies About GeneDecksing
STK17A Antibody Products:
Assay Products for STK17A: |
Protein
Domains /
Families
for STK17A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STK17A for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UEE5ProtoNet protein and cluster: Q9UEE5 UniProtKB/Swiss-Prot: ST17A_HUMAN, Q9UEE5Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamilySimilarity: Contains 1 protein kinase domain |
Function
for STK17A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ST17A_HUMAN, Q9UEE5Function: Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen speciesCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Inhibited by thiazolidinedione-type compounds: inhibited by furan- and pyridone- thiazolidinedionesInduction: Directly regulated by p53/TP53: induced following cisplatin treatment in a p53/TP53-dependent manner.p53/TP53 activates expression by directly binding to its regulatory regions Enzyme Number (IUBMB): EC 2.7.11.11 2
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
STK17A for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for STK17A:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK17A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for STK17A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK17A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK17A |
|
Pathways & Interactions
for STK17A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sweet Taste Signaling | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for STK17A
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STK17A
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for STK17A (ENSP000003191924) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
STK17A for ontologies About GeneDecksing
|
Drugs & Compounds
for STK17A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
STK17A for compounds About GeneDecksing
 Browse Tocris compounds for STK17A
2 HMDB Compounds for STK17A About this table
2 Novoseek chemical compound relationships for STK17A gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| threonine |
44.4 |
2 |
11279167 (1), 10629061 (1) |
| serine |
30.9 |
2 |
11279167 (1), 10629061 (1) |
Search CenterWatch for drugs/clinical trials and news about STK17A / ST17A
|
Transcripts
for STK17A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STK17A gene: NM_004760.2 Unigene Cluster for STK17A: Serine/threonine kinase 17a Hs.709489 [show with all ESTs]Unigene Representative Sequence: NM_0047603 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000462448 ENST00000319357(uc003tih.3) ENST00000474211
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK17A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STK17A (NM_004760) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STK17A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK17A |
Additional cDNA sequence: AB011420.1 BC023508.2 BC047696.1 7 DOTS entries: DT.101980789 DT.444678 DT.91922660 DT.70103355 DT.100793322 DT.95075353 DT.92004129 24/232 AceView cDNA sequences (see all 232): BM128613 AW236955 AI335945 AI142499 CB528466 BF589242 AA455909 BF057275 AI479282 AA251216 CR623604 AV650568 AI184851 BM856569 AA234664 H97625 AI339050 AI073365 AA228041 CF242838 BG620920 AW593835 CR597510 AA478023
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for STK17A About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for STK17A
|
Expression
for STK17A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STK17A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTGGAAGT
About this image
See STK17A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STK17A
SOURCE GeneReport for Unigene cluster: Hs.709489
UniProtKB/Swiss-Prot: ST17A_HUMAN, Q9UEE5Tissue specificity: Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and pancreas
SABiosciences Expression via Pathway-Focused PCR Array including STK17A: | Apoptosis 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STK17A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat STK17A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STK17A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STK17A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK17A |
Orthologs
for STK17A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for STK17A gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
STK17A1 |
serine/threonine kinase 17a |
76.24(n)
79.35(a) |
|
420775 NM_001030995.1 NP_001026166.1 |
lizard
(Anolis carolinensis) |
Reptilia |
STK17A6 |
-- |
76(a) |
1 ↔ 1 |
6(50814562-50844718) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.274692 |
Xenopus laevis transcribed sequence with weak similarity more |
77.18(n) |
|
CA792591.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CA471289.12 |
-- |
73.84(n) |
|
334119 CA471289.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Drak1 |
Death-associated protein kinase related |
48.19(n)
45.92(a) |
|
32097 NM_001169252.1 NP_001162723.1 |
rice
(Oryza sativa) |
Liliopsida |
NM_197303.12 |
-- |
69.72(n) |
|
NM_197303.1 |
ENSEMBL Gene Tree for STK17A (if available)
TreeFam Gene Tree for STK17A (if available) |
Paralogs
for STK17A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STK17A gene
- STK17B2 DAPK22 MYLK22 TTN2 MYLK32 OBSCN2 DAPK32 SPEG2
- MYLK42 DAPK12 OBSL12 MYLK2
18/133 SIMAP similar genes for STK17A using alignment to 3 protein entries: ST17A_HUMAN (see all proteins)
(see all similar genes):STK17B DAPK1 DAPK2 NUAK1 BRSK2 DAPK3
MYLK KALRN CDK4 MYLK3 TRIO TTN
MKNK1 PHKG2 MARK2 PRKAA1 PRKD1 Par1b
STK17A for paralogs About GeneDecksing
|
Genomic Variants
for STK17A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STK17A (43622357 - 43666978 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for STK17A
1 CNV: 64804
1 Indel: 59411 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STK17A |
|
Disorders
/ Diseases
for STK17A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STK17A for disorders About GeneDecksing
OMIM gene information: 604726
OMIM disorders: --
10  diseases for STK17A: About MalaCardstesticular germ cell tumor germ cell tumor embryonal carcinoma testicular cancer
retinoblastoma pancreatic cancer pancreatitis hypertension
thyroiditis carcinoma
Human Genome Epidemiology (HuGE) Navigator: STK17A (3 documents)
Export disorders for STK17A gene to outside databases
|
Publications
for STK17A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STK17A gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with STK17A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. (PubMed id 9786912)1, 2, 3 Sanjo H.... Akira S. (1998)
- Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells. (PubMed id 21489989)1, 2 Mao P....Spinella M.J. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. (PubMed id 21802008)2 Miduturu C.V.... Gray N.S. (2011)
- An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1 Shimada M....Tokunaga K. (2010)
- The variant rs1867277 in FOXE1 gene confers thyroid c ancer susceptibility through the recruitment of USF1/USF2 transcription factors . (PubMed id 19730683)1 Landa I....Robledo M. (2009)
|
External Searches for STK17A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STK17A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STK17A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STK17A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for STK17A gene:
Search GeneIP for patents involving STK17A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STK17A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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