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Aliases for STK16 Gene

Aliases for STK16 Gene

  • Serine/Threonine Kinase 16 2 3
  • Myristoylated And Palmitoylated Serine/Threonine-Protein Kinase 3 4
  • Tyrosine-Protein Kinase STK16 3 4
  • TGF-Beta-Stimulated Factor 1 3 4
  • Protein Kinase PKL12 3 4
  • EC 2.7.11.1 4 64
  • PKL12 3 4
  • TSF-1 3 4
  • MPSK 3 4
  • TSF1 3 4
  • HPSK 3 4
  • Protein Kinase Expressed In Day 12 Fetal Liver 3
  • Serine/Threonine-Protein Kinase 16 3
  • EC 2.7.10.2 4
  • MPSK1 4
  • KRCT 3

External Ids for STK16 Gene

Summaries for STK16 Gene

GeneCards Summary for STK16 Gene

STK16 (Serine/Threonine Kinase 16) is a Protein Coding gene. Diseases associated with STK16 include essential thrombocythemia and diffuse mesangial sclerosis. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include protein serine/threonine kinase activity and non-membrane spanning protein tyrosine kinase activity.

UniProtKB/Swiss-Prot for STK16 Gene

  • Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.

Gene Wiki entry for STK16 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK16 Gene

Genomics for STK16 Gene

Genomic Location for STK16 Gene

Start:
219,245,455 bp from pter
End:
219,250,337 bp from pter
Size:
4,883 bases
Orientation:
Plus strand

Genomic View for STK16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STK16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK16 Gene

Regulatory Elements for STK16 Gene

Proteins for STK16 Gene

  • Protein details for STK16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75716-STK16_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 16
    Protein Accession:
    O75716
    Secondary Accessions:
    • A8K9H9
    • Q5U0F8
    • Q96KI2
    • Q9BUH4
    • Q9UEN3
    • Q9UP78

    Protein attributes for STK16 Gene

    Size:
    305 amino acids
    Molecular mass:
    34656 Da
    Quaternary structure:
    • Monomer. Interacts with DRG1 (via its N-terminal); the interaction phosphorylates DRG1.
    SequenceCaution:
    • Sequence=AAV38392.1; Type=Frameshift; Positions=305; Evidence={ECO:0000305}; Sequence=CAA06700.1; Type=Frameshift; Positions=305; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STK16 Gene

neXtProt entry for STK16 Gene

Proteomics data for STK16 Gene at MOPED

Selected DME Specific Peptides for STK16 Gene

Post-translational modifications for STK16 Gene

  • It is uncertain whether palmitoylation is on Cys-6 and/or Cys-8.
  • Mainly autophosphorylated on serine/threonine residues. Also autophosphorylated on Tyr-198.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys102

Other Protein References for STK16 Gene

Domains for STK16 Gene

Gene Families for STK16 Gene

Protein Domains for STK16 Gene

UniProtKB/Swiss-Prot:

STK16_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • O75716
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.:
    • O75716
genes like me logo Genes that share domains with STK16: view

Function for STK16 Gene

Molecular function for STK16 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.

Enzyme Numbers (IUBMB) for STK16 Gene

Gene Ontology (GO) - Molecular Function for STK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with STK16: view
genes like me logo Genes that share phenotypes with STK16: view

miRNA for STK16 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for STK16 Gene

Localization for STK16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK16 Gene

Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Note=Associates with Golgi and Golgi-derived vesicles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK16 Gene COMPARTMENTS Subcellular localization image for STK16 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
chloroplast 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005798 Golgi-associated vesicle IEA --
GO:0016020 membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with STK16: view

Pathways for STK16 Gene

SuperPathways for STK16 Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK16: view

Pathways by source for STK16 Gene

1 Qiagen pathway for STK16 Gene

Gene Ontology (GO) - Biological Process for STK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0009966 regulation of signal transduction IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:0046777 protein autophosphorylation IDA 18184589
genes like me logo Genes that share ontologies with STK16: view

Compounds for STK16 Gene

(2) HMDB Compounds for STK16 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with STK16: view

Transcripts for STK16 Gene

Unigene Clusters for STK16 Gene

Serine/threonine kinase 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK16 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: -

Relevant External Links for STK16 Gene

GeneLoc Exon Structure for
STK16
ECgene alternative splicing isoforms for
STK16

Expression for STK16 Gene

mRNA expression in normal human tissues for STK16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for STK16 Gene

SOURCE GeneReport for Unigene cluster for STK16 Gene Hs.153003

mRNA Expression by UniProt/SwissProt for STK16 Gene

O75716-STK16_HUMAN
Tissue specificity: Ubiquitously expressed at very low levels.
genes like me logo Genes that share expressions with STK16: view

Orthologs for STK16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK16 36
  • 99.56 (n)
  • 99.67 (a)
STK16 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STK16 36
  • 90.82 (n)
  • 92.13 (a)
STK16 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK16 36
  • 92.79 (n)
  • 95.74 (a)
STK16 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk16 36
  • 89.18 (n)
  • 94.1 (a)
Stk16 16
Stk16 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK16 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk16 36
  • 89.95 (n)
  • 95.41 (a)
chicken
(Gallus gallus)
Aves STK16 36
  • 71.37 (n)
  • 68.2 (a)
STK16 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK16 37
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24224 36
tropical clawed frog
(Silurana tropicalis)
Amphibia stk16 36
  • 69.95 (n)
  • 67.87 (a)
Str.4158 36
zebrafish
(Danio rerio)
Actinopterygii stk16 36
  • 67.35 (n)
  • 66.33 (a)
stk16 37
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1227 36
  • 51.09 (n)
  • 42.39 (a)
CG1227 37
  • 38 (a)
OneToOne
CG1227 38
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea D2045.7 37
  • 24 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL143C 36
  • 45.57 (n)
  • 29.37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENV7 36
  • 43.14 (n)
  • 36.33 (a)
ENV7 37
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons PK3 36
  • 49.25 (n)
  • 39.02 (a)
rice
(Oryza sativa)
Liliopsida Os09g0372800 36
  • 48.46 (n)
  • 38.3 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07399 36
  • 49.61 (n)
  • 38.98 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppk13 36
  • 44.05 (n)
  • 35.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
OneToOne
Species with no ortholog for STK16:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK16 Gene

ENSEMBL:
Gene Tree for STK16 (if available)
TreeFam:
Gene Tree for STK16 (if available)

Paralogs for STK16 Gene

Selected SIMAP similar genes for STK16 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for STK16 Gene

genes like me logo Genes that share paralogs with STK16: view

No data available for Paralogs for STK16 Gene

Variants for STK16 Gene

Sequence variations from dbSNP and Humsavar for STK16 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs8447 -- 219,248,662(-) TACCC(C/T)CAAGT utr-variant-3-prime, nc-transcript-variant
rs885854 -- 219,249,006(-) CGACT(C/T)TGCAC utr-variant-3-prime, nc-transcript-variant
rs1056679 -- 219,248,705(+) CTTTT(C/T)TTCTG utr-variant-3-prime, nc-transcript-variant
rs1134896 -- 219,247,738(+) CATCG(A/G)TGAGC reference, missense, nc-transcript-variant
rs3180305 -- 219,248,906(+) GTGTA(A/G)ATCTT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for STK16 Gene

Variant ID Type Subtype PubMed ID
nsv834543 CNV Loss 17160897
nsv508885 CNV Insertion 20534489

Relevant External Links for STK16 Gene

HapMap Linkage Disequilibrium report
STK16

Disorders for STK16 Gene

(3) University of Copenhagen DISEASES for STK16 Gene

(2) Novoseek inferred disease relationships for STK16 Gene

Disease -log(P) Hits PubMed IDs
necrosis 25.1 2
tumors 10.5 2
genes like me logo Genes that share disorders with STK16: view

No data available for UniProtKB/Swiss-Prot for STK16 Gene

Publications for STK16 Gene

  1. A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway. (PMID: 10947953) Ohta S. … Nagata K. (Biochem. J. 2000) 3 4 23
  2. Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases. (PMID: 9712705) Ligos J.M. … Bernad A. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  3. Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase. (PMID: 10364453) Berson A.E. … Burkhardt A.L. (Biochem. Biophys. Res. Commun. 1999) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture. (PMID: 18184589) Eswaran J. … Knapp S. (Structure 2008) 3 4

Products for STK16 Gene

  • Addgene plasmids for STK16

Sources for STK16 Gene

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