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Aliases for STK16 Gene

Aliases for STK16 Gene

  • Serine/Threonine Kinase 16 2 3 5
  • Myristoylated And Palmitoylated Serine/Threonine-Protein Kinase 3 4
  • Tyrosine-Protein Kinase STK16 3 4
  • TGF-Beta-Stimulated Factor 1 3 4
  • Protein Kinase PKL12 3 4
  • EC 2.7.11.1 4 63
  • PKL12 3 4
  • TSF-1 3 4
  • MPSK 3 4
  • TSF1 3 4
  • HPSK 3 4
  • Protein Kinase Expressed In Day 12 Fetal Liver 3
  • EC 2.7.10.2 4
  • MPSK1 4
  • KRCT 3

External Ids for STK16 Gene

Previous GeneCards Identifiers for STK16 Gene

  • GC02P218126
  • GC02P218831
  • GC02P220074
  • GC02P220312
  • GC02P220313
  • GC02P219935
  • GC02P219818
  • GC02P220110
  • GC02P211963

Summaries for STK16 Gene

GeneCards Summary for STK16 Gene

STK16 (Serine/Threonine Kinase 16) is a Protein Coding gene. Diseases associated with STK16 include diffuse mesangial sclerosis. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

UniProtKB/Swiss-Prot for STK16 Gene

  • Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.

Gene Wiki entry for STK16 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK16 Gene

Genomics for STK16 Gene

Regulatory Elements for STK16 Gene

Promoters for STK16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STK16 on UCSC Golden Path with GeneCards custom track

Genomic Location for STK16 Gene

Chromosome:
2
Start:
219,245,455 bp from pter
End:
219,250,337 bp from pter
Size:
4,883 bases
Orientation:
Plus strand

Genomic View for STK16 Gene

Genes around STK16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK16 Gene

Proteins for STK16 Gene

  • Protein details for STK16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75716-STK16_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 16
    Protein Accession:
    O75716
    Secondary Accessions:
    • A8K9H9
    • Q5U0F8
    • Q96KI2
    • Q9BUH4
    • Q9UEN3
    • Q9UP78

    Protein attributes for STK16 Gene

    Size:
    305 amino acids
    Molecular mass:
    34656 Da
    Quaternary structure:
    • Monomer. Interacts with DRG1 (via its N-terminal); the interaction phosphorylates DRG1.
    SequenceCaution:
    • Sequence=AAV38392.1; Type=Frameshift; Positions=305; Evidence={ECO:0000305}; Sequence=CAA06700.1; Type=Frameshift; Positions=305; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STK16 Gene

neXtProt entry for STK16 Gene

Proteomics data for STK16 Gene at MOPED

Selected DME Specific Peptides for STK16 Gene

Post-translational modifications for STK16 Gene

  • It is uncertain whether palmitoylation is on Cys-6 and/or Cys-8.
  • Mainly autophosphorylated on serine/threonine residues. Also autophosphorylated on Tyr-198.
  • Ubiquitination at Lys 102
  • Modification sites at PhosphoSitePlus

Other Protein References for STK16 Gene

Antibody Products

Domains & Families for STK16 Gene

Gene Families for STK16 Gene

Protein Domains for STK16 Gene

Suggested Antigen Peptide Sequences for STK16 Gene

Graphical View of Domain Structure for InterPro Entry

O75716

UniProtKB/Swiss-Prot:

STK16_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with STK16: view

Function for STK16 Gene

Molecular function for STK16 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.

Enzyme Numbers (IUBMB) for STK16 Gene

Gene Ontology (GO) - Molecular Function for STK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IBA --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with STK16: view
genes like me logo Genes that share phenotypes with STK16: view

Animal Models for STK16 Gene

MGI Knock Outs for STK16:

Animal Model Products

  • Taconic Biosciences Mouse Models for STK16

miRNA for STK16 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STK16 Gene

Localization for STK16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK16 Gene

Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Note=Associates with Golgi and Golgi-derived vesicles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK16 Gene COMPARTMENTS Subcellular localization image for STK16 gene
Compartment Confidence
cytosol 3
golgi apparatus 3
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with STK16: view

Pathways & Interactions for STK16 Gene

SuperPathways for STK16 Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK16: view

Pathways by source for STK16 Gene

1 Qiagen pathway for STK16 Gene

Gene Ontology (GO) - Biological Process for STK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0046777 protein autophosphorylation IDA 18184589
GO:0071560 cellular response to transforming growth factor beta stimulus IEA,IBA --
genes like me logo Genes that share ontologies with STK16: view

No data available for SIGNOR curated interactions for STK16 Gene

Drugs & Compounds for STK16 Gene

(1) Drugs for STK16 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for STK16 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK16: view

Transcripts for STK16 Gene

Unigene Clusters for STK16 Gene

Serine/threonine kinase 16:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK16 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: -

Relevant External Links for STK16 Gene

GeneLoc Exon Structure for
STK16
ECgene alternative splicing isoforms for
STK16

Expression for STK16 Gene

mRNA expression in normal human tissues for STK16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STK16 Gene

This gene is overexpressed in Lung (53.6) and Salivary gland (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STK16 Gene



SOURCE GeneReport for Unigene cluster for STK16 Gene Hs.153003

mRNA Expression by UniProt/SwissProt for STK16 Gene

O75716-STK16_HUMAN
Tissue specificity: Ubiquitously expressed at very low levels.
genes like me logo Genes that share expression patterns with STK16: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for STK16 Gene

Orthologs for STK16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STK16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK16 36
  • 100 (a)
OneToOne
STK16 35
  • 99.56 (n)
  • 99.67 (a)
cow
(Bos Taurus)
Mammalia STK16 36
  • 92 (a)
OneToOne
STK16 35
  • 90.82 (n)
  • 92.13 (a)
dog
(Canis familiaris)
Mammalia STK16 35
  • 92.79 (n)
  • 95.74 (a)
STK16 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk16 16
Stk16 35
  • 89.18 (n)
  • 94.1 (a)
Stk16 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK16 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk16 35
  • 89.95 (n)
  • 95.41 (a)
chicken
(Gallus gallus)
Aves STK16 35
  • 71.37 (n)
  • 68.2 (a)
STK16 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK16 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24224 35
tropical clawed frog
(Silurana tropicalis)
Amphibia stk16 35
  • 69.95 (n)
  • 67.87 (a)
Str.4158 35
zebrafish
(Danio rerio)
Actinopterygii stk16 36
  • 64 (a)
OneToOne
stk16 35
  • 67.35 (n)
  • 66.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1227 36
  • 38 (a)
OneToOne
CG1227 37
  • 40 (a)
CG1227 35
  • 51.09 (n)
  • 42.39 (a)
worm
(Caenorhabditis elegans)
Secernentea D2045.7 36
  • 24 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL143C 35
  • 45.57 (n)
  • 29.37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENV7 35
  • 43.14 (n)
  • 36.33 (a)
ENV7 36
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons PK3 35
  • 49.25 (n)
  • 39.02 (a)
rice
(Oryza sativa)
Liliopsida Os09g0372800 35
  • 48.46 (n)
  • 38.3 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07399 35
  • 49.61 (n)
  • 38.98 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppk13 35
  • 44.05 (n)
  • 35.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for STK16:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK16 Gene

ENSEMBL:
Gene Tree for STK16 (if available)
TreeFam:
Gene Tree for STK16 (if available)

Paralogs for STK16 Gene

(2) SIMAP similar genes for STK16 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for STK16 Gene

genes like me logo Genes that share paralogs with STK16: view

No data available for Paralogs for STK16 Gene

Variants for STK16 Gene

Sequence variations from dbSNP and Humsavar for STK16 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_041140 -
VAR_041141 -
VAR_041142 -
rs17849638 - 219,248,437(+) CATTG(C/T)GGCAG nc-transcript-variant, reference, missense
rs35454203 - 219,248,471(+) GGACC(C/T)GCATC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for STK16 Gene

Variant ID Type Subtype PubMed ID
nsv834543 CNV Loss 17160897
nsv508885 CNV Insertion 20534489

Variation tolerance for STK16 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK16 Gene

HapMap Linkage Disequilibrium report
STK16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK16 Gene

Disorders for STK16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STK16 Gene - From: GeneCards

Disorder Aliases PubMed IDs
diffuse mesangial sclerosis
  • diffuse isolated mesangial sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search STK16 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STK16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK16
genes like me logo Genes that share disorders with STK16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STK16 Gene

Publications for STK16 Gene

  1. Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases. (PMID: 9712705) Ligos J.M. … Bernad A. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 67
  2. A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway. (PMID: 10947953) Ohta S. … Nagata K. (Biochem. J. 2000) 3 23
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The EHEC-host interactome reveals novel targets for the translocated intimin receptor. (PMID: 25519916) Blasche S. … Koegl M. (Sci Rep 2014) 3
  5. Serine/threonine kinase 16 and MAL2 regulate constitutive secretion of soluble cargo in hepatic cells. (PMID: 25084525) In J.G. … Tuma P.L. (Biochem. J. 2014) 3

Products for STK16 Gene

Sources for STK16 Gene

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