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STK16 Gene

protein-coding   GIFtS: 62
GCID: GC02P220110

Serine/Threonine Kinase 16

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Threonine Kinase 161 2     hPSK2 3
Myristoylated And Palmitoylated Serine/Threonine-Protein Kinase2 3     TGF-Beta-Stimulated Factor 12 3
Protein Kinase PKL122 3     EC 2.7.11.13 8
Tyrosine-Protein Kinase STK162 3     KRCT2
MPSK2 3     Protein Kinase Expressed In Day 12 Fetal Liver2
PKL122 3     Serine/Threonine-Protein Kinase 162
TSF-12 3     EC 2.7.10.23
TSF12 3     MPSK13

External Ids:    HGNC: 113941   Entrez Gene: 85762   Ensembl: ENSG000001156617   OMIM: 6047195   UniProtKB: O757163   

Export aliases for STK16 gene to outside databases

Previous GC identifers: GC02P218126 GC02P218831 GC02P220074 GC02P220312 GC02P220313 GC02P219935 GC02P219818 GC02P211963


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STK16 Gene:
STK16 (serine/threonine kinase 16) is a protein-coding gene. Diseases associated with STK16 include diffuse mesangial sclerosis, and mast cell neoplasm. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity and protein serine/threonine kinase activity.

UniProtKB/Swiss-Prot: STK16_HUMAN, O75716
Function: Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro
substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle
trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur
during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to
autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other
proteins

Gene Wiki entry for STK16 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the STK16 gene promoter:
         AP-1   MyoD   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK16 promoter sequence
   Search Chromatin IP Primers for STK16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

STK16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK16 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P220110:  view genomic region     (about GC identifiers)

Start:
220,110,177 bp from pter      End:
220,115,059 bp from pter
Size:
4,883 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STK16_HUMAN, O75716 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 16  
Size: 305 amino acids; 34656 Da
Subunit: Monomer. Interacts with DRG1 (via its N-terminal); the interaction phosphorylates DRG1
Sequence caution: Sequence=AAV38392.1; Type=Frameshift; Positions=305; Sequence=CAA06700.1; Type=Frameshift;
Positions=305;
1 PDB 3D structure from and Proteopedia for STK16:
2BUJ (3D)    
Secondary accessions: A8K9H9 Q5U0F8 Q96KI2 Q9BUH4 Q9UEN3 Q9UP78

Explore the universe of human proteins at neXtProt for STK16: NX_O75716

Explore proteomics data for STK16 at MOPED

Post-translational modifications: 

  • Mainly autophosphorylated on serine/threonine residues. Also autophosphorylated on Tyr-1981
  • It is uncertain whether palmitoylation is on Cys-6 and/or Cys-81
  • Ubiquitination2 at Lys102
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for STK16 (O75716)
     YALKRIL  EGGFSYV 


    See STK16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001008910.1  
    ENSEMBL proteins: 
     ENSP00000386928   ENSP00000379964   ENSP00000386309   ENSP00000387156   ENSP00000386553  

    STK16 Human Recombinant Protein Products:

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    Novus Biologicals STK16 Proteins
    Novus Biologicals STK16 Lysates
    Sino Biological Recombinant Protein for STK16
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    ProSpec Recombinant Protein for STK16
    Cloud-Clone Corp. Proteins for STK16

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    STK16 Assay Products:

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    Cloud-Clone Corp. ELISAs for STK16
    Cloud-Clone Corp. CLIAs for STK16


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine kinase 16
    NAK family

    3 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O75716

    ProtoNet protein and cluster: O75716

    UniProtKB/Swiss-Prot: STK16_HUMAN, O75716
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    STK16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STK16_HUMAN, O75716
    Function: Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro
    substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle
    trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur
    during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to
    autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other
    proteins
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.10.21

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
         
    STK16 for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for STK16:
     Decreased Hepatitis C virus re  Decreased focal adhesion (FA)   Decreased telomerase activity  Increased S DNA content 
     Increased cell death in HCT116  Increased gamma-H2AX phosphory  Increased number of mitotic ce  Paclitaxel sensitizing effect 

         1 MGI phenotypic allele for Stk16 (no phenotypes)

    STK16 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STK16
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STK16

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STK16
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STK16

    miRNA
    Products:
        
    miRTarBase miRNAs that target STK16:
    hsa-mir-324-3p (MIRT042840), hsa-mir-26b-5p (MIRT029140), hsa-mir-365a-3p (MIRT044034), hsa-mir-744-5p (MIRT037413)

    Block miRNA regulation of human, mouse, rat STK16 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK16 (see all 30):
    hsa-miR-4291 hsa-miR-1287 hsa-miR-100* hsa-miR-185* hsa-miR-578 hsa-miR-1285 hsa-miR-4299 hsa-miR-500a
    SwitchGear 3'UTR luciferase reporter plasmidSTK16 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STK16

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for STK16
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STK16 (NM_001008910)
    Sino Biological Human cDNA Clone for STK16
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STK16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK16

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for STK16 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK16


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STK16_HUMAN, O75716: Cytoplasm, perinuclear region. Membrane; Lipid-anchor (By similarity). Note=Associates with
    Golgi and Golgi-derived vesicles (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    golgi apparatus2
    chloroplast1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005798Golgi-associated vesicle IEA--
    GO:0016020membrane IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    STK16 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STK16 About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sperm Motility0.37

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STK16
        Sperm Motility



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STK16
    Interactions:

        GeneGlobe Interaction Network for STK16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STK16 (O757161, 2, 3 ENSP000003799644) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253660 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253660 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253660 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253660 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253660 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0045944positive regulation of transcription from RNA polymerase II promoter ----
    GO:0046777protein autophosphorylation IDA18184589
    GO:0071560cellular response to transforming growth factor beta stimulus IEA--

    STK16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STK16

    2 HMDB Compounds for STK16    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STK16 gene (3 alternative transcripts): 
    NM_003691.2  NM_032768.1  NM_001008910.2  

    Unigene Cluster for STK16:

    Serine/threonine kinase 16
    Hs.153003  [show with all ESTs]
    Unigene Representative Sequence: NR_026909
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409638(uc002vko.2 uc002vks.2 uc002vkp.2) ENST00000491697
    ENST00000461417 ENST00000475696(uc010fwf.3) ENST00000396738 ENST00000409516
    ENST00000496443 ENST00000496800(uc010zky.2) ENST00000475342 ENST00000409260
    ENST00000478018 ENST00000486813 ENST00000409743
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STK16 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK16 (see all 30):
    hsa-miR-4291 hsa-miR-1287 hsa-miR-100* hsa-miR-185* hsa-miR-578 hsa-miR-1285 hsa-miR-4299 hsa-miR-500a
    SwitchGear 3'UTR luciferase reporter plasmidSTK16 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STK16
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STK16 (NM_001008910)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK16
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for STK16
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STK16
      QuantiTect SYBR Green Assays in human, mouse, rat STK16
      QuantiFast Probe-based Assays in human, mouse, rat STK16

    Additional mRNA sequence: 

    AB020739.1 AF060798.1 AF203910.1 AJ005791.1 AJ010872.1 AK225526.1 AK292694.1 AK298471.1 
    BC002618.2 BC007381.2 BC019915.1 BC053998.1 BT019585.1 CR407675.1 NR_026909.1 

    20 DOTS entries:

    DT.410473  DT.92446288  DT.100701499  DT.97798604  DT.95258481  DT.100891688  DT.100891693  DT.95145743 
    DT.121017638  DT.100891684  DT.121017577  DT.95119848  DT.95127431  DT.92446286  DT.95145748  DT.100810991 
    DT.100891691  DT.118885  DT.75145646  DT.121017540 

    Selected AceView cDNA sequences (see all 194):

    BI906217 BI755751 AL520128 BG674103 BP367428 BG742034 AB020739 CB111662 
    BE267910 BI915545 BF968888 CR622571 BX443461 AW292201 BE710111 BM904353 
    BM924507 CD671696 BM474191 CR618122 BC007381 BE513894 BX345069 BX403332 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STK16 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                                -     -           -                                       
    SP2:                    -           -     -           -                                       
    SP3:                                                  -     -                                 
    SP4:                                -     -           -                                       
    SP5:                                -                 -                                       


    ECgene alternative splicing isoforms for STK16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STK16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCTGAGCA
    STK16 Expression
    About this image


    STK16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Lymph (Hematopoietic System)
    STK16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STK16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.153003

    UniProtKB/Swiss-Prot: STK16_HUMAN, O75716
    Tissue specificity: Ubiquitously expressed at very low levels

        Custom PCR Arrays for STK16
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    QuantiFast Probe-based Assays in human, mouse, rat STK16
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STK16 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk161 , 5 serine/threonine kinase 161, 5 89.18(n)1
    94.1(a)1
      1 (38.63 cM)5
    208721  NM_001277992.11  NP_001264921.11 
     752108385 
    chicken
    (Gallus gallus)
    Aves STK161 serine/threonine kinase 16 71.37(n)
    68.2(a)
      429036  XM_426593.4  XP_426593.1 
    lizard
    (Anolis carolinensis)
    Reptilia STK166
    serine/threonine kinase 16
    72(a)
    1 ↔ 1
    1(95732960-95747445)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.242242 Xenopus laevis transcribed sequence with moderate similarity more 75.5(n)    BX849857.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stk161 serine/threonine kinase 16 67.35(n)
    66.33(a)
      550323  NM_001017630.1  NP_001017630.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG12271 , 3 protein amino acid phosphorylation
    protein kinase3
    CG12271
    40(a)3
    51.09(n)1
    42.39(a)1
      84D33
    408721  NM_141455.31  NP_649712.11 
    worm
    (Caenorhabditis elegans)
    Secernentea D2045.76
    Protein D2045.7 (D2045.7) mRNA, complete cds
    24(a)
    1 ↔ 1
    III(10479884-10482144) WBGene00008424
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ENV71 ENV7 43.14(n)
    36.33(a)
      855840   NP_015088.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PK31 PK3 49.25(n)
    39.02(a)
      830712  NM_120899.2  NP_196433.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g03728001 Os09g0372800 48.46(n)
    38.3(a)
      4346899  NM_001069562.1  NP_001063027.1 


    ENSEMBL Gene Tree for STK16 (if available)
    TreeFam Gene Tree for STK16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STK16 gene
    2 SIMAP similar genes for STK16 using alignment to 4 protein entries:     STK16_HUMAN (see all proteins):
    DKFZp564L2416    RPS6KA2

    STK16 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STK16
    PGOHUM00000248162


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STK16 (see all 160)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2021031611,2
    --219488665(+) AGCCAC/TGGCGT 2 -- us2k10--------
    rs115527961,2
    C,F,H--219488670(-) TGTAAA/GCGCCA 2 -- us2k119Minor allele frequency- G:0.16NS EA WA NA CSA EU 3255
    rs2011427071,2
    --219488684(+) CTCCTC/TTAGTC 2 -- us2k10--------
    rs353280011,2
    C,F,H--219488793(+) GACTTC/TCTCTC 2 -- us2k118Minor allele frequency- T:0.17NS EA NA CSA WA 2222
    rs101944921,2
    C,F,H--219488884(+) TCGACG/ATCACC 2 -- us2k1 tfbs315Minor allele frequency- A:0.09NS NA WA CSA EA 1163
    rs1846394731,2
    C--219489056(+) TAGCCG/TGGCCT 2 -- us2k10--------
    rs1887590291,2
    --219489264(+) AACCGA/GGATCC 2 -- us2k10--------
    rs1138251441,2
    C--219489301(+) AGAGCG/TAGACT 2 -- us2k10--------
    rs1923515711,2
    --219489478(+) GAGTGC/TCCTGT 2 -- us2k10--------
    rs1426851851,2
    --219489561(+) AACCAA/TAAGGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for STK16 (220110177 - 220115059 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STK16:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508885CNV Insertion20534489
    nsv834543CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STK16
    DNA2.0 Custom Variant and Variant Library Synthesis for STK16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604719    OMIM disorders: --

    Selected diseases for STK16 (see all 23):    
    About MalaCards
    diffuse mesangial sclerosis    mast cell neoplasm    cryptococcosis    interstitial nephritis
    essential thrombocythemia    interstitial lung disease    newcastle disease    congestive heart failure
    bronchopulmonary dysplasia    giant cell tumor    leprosy    thymoma
    nephritis    intrahepatic cholangiocarcinoma    cholangiocarcinoma    pulmonary fibrosis
    rheumatoid arthritis    arthritis    multiple sclerosis    esophagitis

    3 diseases from the University of Copenhagen DISEASES database for STK16:
    Cryptococcosis     Interstitial nephritis     Thymoma

    STK16 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for STK16 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 25.1 2 19039999 (1), 15501026 (1)
    tumors 10.5 4 19039999 (1), 15501026 (1)


    Export disorders for STK16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STK16 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with STK16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases. (PubMed id 9712705)1, 2, 3 Ligos J.M.... Bernad A. (Biochem. Biophys. Res. Commun. 1998)
    2. A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway. (PubMed id 10947953)1, 2, 9 Ohta S.... Nagata K. (Biochem. J. 2000)
    3. Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture. (PubMed id 18184589)1, 2 Eswaran J.... Knapp S. (Structure 2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase. (PubMed id 10364453)1, 2 Berson A.E.... Burkhardt A.L. (Biochem. Biophys. Res. Commun. 1999)
    7. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. An empirical framework for binary interactome mapping. (PubMed id 19060904)1 Venkatesan K....Vidal M. (Nat. Methods 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8576 HGNC: 11394 AceView: STK16 Ensembl:ENSG00000115661 euGenes: HUgn8576
    ECgene: STK16 H-InvDB: STK16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STK16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STK16 gene:
    Search GeneIP for patents involving STK16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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