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Aliases for STK11IP Gene

Aliases for STK11IP Gene

  • Serine/Threonine Kinase 11 Interacting Protein 2 3 5
  • LKB1-Interacting Protein 1 3 4
  • STK11IP1 3 4
  • LKB1IP 3 4
  • LIP1 3 4
  • Serine/Threonine-Protein Kinase 11-Interacting Protein 3
  • STK11 Interacting Protein 3
  • LKB1 Interacting Protein 2
  • KIAA1898 4

External Ids for STK11IP Gene

Previous GeneCards Identifiers for STK11IP Gene

  • GC02P218485
  • GC02P219183
  • GC02P220426
  • GC02P220665
  • GC02P220288
  • GC02P220170
  • GC02P220462
  • GC02P212315

Summaries for STK11IP Gene

GeneCards Summary for STK11IP Gene

STK11IP (Serine/Threonine Kinase 11 Interacting Protein) is a Protein Coding gene. Among its related pathways are Innate Immune System and LKB1 signaling events. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is NISCH.

UniProtKB/Swiss-Prot for STK11IP Gene

  • May regulate STK11/LKB1 function by controlling its subcellular localization.

Additional gene information for STK11IP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK11IP Gene

Genomics for STK11IP Gene

Regulatory Elements for STK11IP Gene

Enhancers for STK11IP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H219569 1.1 ENCODE 21.1 -26.3 -26329 4 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF416 FOS ZNF142 RNF25 NHEJ1 INHA SLC23A3 STK36 STK11IP GLB1L DNPEP BCS1L
GH02H219368 1.2 Ensembl ENCODE 18.8 -228.6 -228555 2 FOXA2 FEZF1 ZNF2 GATA2 ZNF416 KLF7 YY2 REST TSHZ1 ZNF488 ZNF142 RNF25 STK36 CNOT9 ENSG00000269068 STK11IP ENSG00000268896 ANKZF1 OBSL1 GLB1L
GH02H218908 2 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -688.3 -688262 2 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B CNOT9 STK36 ZNF142 USP37 AAMP OBSL1 NHEJ1 CDK5R2 ENSG00000235024 ENSG00000269068
GH02H219294 1.4 ENCODE dbSUPER 13.3 -303.0 -303014 1 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B PTPRN CNOT9 STK11IP RNF25 ZNF142 BCS1L STK36 TTLL4 ENSG00000230432 MIR153-1
GH02H218710 1.4 ENCODE dbSUPER 13.3 -886.6 -886649 2 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B AAMP CNOT9 STK36 DES ANKZF1 LINC00608 ENSG00000234638 RNF25 STK11IP TNS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STK11IP on UCSC Golden Path with GeneCards custom track

Genomic Location for STK11IP Gene

Chromosome:
2
Start:
219,597,860 bp from pter
End:
219,616,451 bp from pter
Size:
18,592 bases
Orientation:
Plus strand

Genomic View for STK11IP Gene

Genes around STK11IP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK11IP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK11IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK11IP Gene

Proteins for STK11IP Gene

  • Protein details for STK11IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1F8-S11IP_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 11-interacting protein
    Protein Accession:
    Q8N1F8
    Secondary Accessions:
    • Q8NAW9
    • Q8WXE4
    • Q96CN3
    • Q96PY9

    Protein attributes for STK11IP Gene

    Size:
    1099 amino acids
    Molecular mass:
    121401 Da
    Quaternary structure:
    • Found in a ternary complex composed of STK11/LKB1, STK11IP and SMAD4. Interacts with STK11/LKB1 and SMAD4.
    Miscellaneous:
    • This gene contains a polymorphic substitution resulting in a variant amino acid from Met-1 to Arg-1 compared to the official human genome. However, this variant sequence is in agreement with EST and mRNA sequences.

    Alternative splice isoforms for STK11IP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK11IP Gene

Post-translational modifications for STK11IP Gene

  • Ubiquitination at posLast=114114 and Lys294
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STK11IP Gene

Domains & Families for STK11IP Gene

Gene Families for STK11IP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STK11IP Gene

Suggested Antigen Peptide Sequences for STK11IP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N1F8

UniProtKB/Swiss-Prot:

S11IP_HUMAN :
  • Belongs to the STK11IP family.
Family:
  • Belongs to the STK11IP family.
genes like me logo Genes that share domains with STK11IP: view

Function for STK11IP Gene

Molecular function for STK11IP Gene

UniProtKB/Swiss-Prot Function:
May regulate STK11/LKB1 function by controlling its subcellular localization.

Phenotypes From GWAS Catalog for STK11IP Gene

Gene Ontology (GO) - Molecular Function for STK11IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 11741830
genes like me logo Genes that share ontologies with STK11IP: view
genes like me logo Genes that share phenotypes with STK11IP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STK11IP

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for STK11IP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK11IP Gene

Localization for STK11IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK11IP Gene

Cytoplasm. Note=Some cells show granular or punctuate expression. Colocalizes with STK11/LKB1 and SMAD4 in granular or punctuate structures.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK11IP gene
Compartment Confidence
lysosome 5
extracellular 4
cytosol 3
plasma membrane 2
mitochondrion 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STK11IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IDA 11741830
GO:0005765 lysosomal membrane IDA 17897319
GO:0035578 azurophil granule lumen TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with STK11IP: view

Pathways & Interactions for STK11IP Gene

genes like me logo Genes that share pathways with STK11IP: view

Pathways by source for STK11IP Gene

1 BioSystems pathway for STK11IP Gene
3 Reactome pathways for STK11IP Gene

Interacting Proteins for STK11IP Gene

Selected Interacting proteins: Q8N1F8-S11IP_HUMAN for STK11IP Gene via IID

Gene Ontology (GO) - Biological Process for STK11IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008104 protein localization IDA 11741830
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with STK11IP: view

No data available for SIGNOR curated interactions for STK11IP Gene

Drugs & Compounds for STK11IP Gene

No Compound Related Data Available

Transcripts for STK11IP Gene

Unigene Clusters for STK11IP Gene

Serine/threonine kinase 11 interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for STK11IP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for STK11IP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - - -
SP2: - - - -
SP3: -
SP4: - - -
SP5:
SP6:
SP7: - - -
SP8:
SP9:
SP10: - -

ExUns: 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for STK11IP Gene

GeneLoc Exon Structure for
STK11IP
ECgene alternative splicing isoforms for
STK11IP

Expression for STK11IP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STK11IP Gene

Protein differential expression in normal tissues from HIPED for STK11IP Gene

This gene is overexpressed in Breast (31.8), Pancreas (8.5), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STK11IP Gene



Protein tissue co-expression partners for STK11IP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STK11IP Gene:

STK11IP

SOURCE GeneReport for Unigene cluster for STK11IP Gene:

Hs.22410

Evidence on tissue expression from TISSUES for STK11IP Gene

  • Nervous system(4.5)
  • Kidney(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with STK11IP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STK11IP Gene

Orthologs for STK11IP Gene

This gene was present in the common ancestor of animals.

Orthologs for STK11IP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK11IP 34 33
  • 99.02 (n)
OneToOne
dog
(Canis familiaris)
Mammalia STK11IP 34 33
  • 82.09 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk11ip 33
  • 79.73 (n)
mouse
(Mus musculus)
Mammalia Stk11ip 34 16 33
  • 79.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STK11IP 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK11IP 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK11IP 34 33
  • 58.32 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK11IP 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk11ip 33
  • 49.53 (n)
zebrafish
(Danio rerio)
Actinopterygii stk11ip 34 33
  • 48.29 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9044 34
  • 18 (a)
OneToOne
Species where no ortholog for STK11IP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STK11IP Gene

ENSEMBL:
Gene Tree for STK11IP (if available)
TreeFam:
Gene Tree for STK11IP (if available)

Paralogs for STK11IP Gene

Paralogs for STK11IP Gene

genes like me logo Genes that share paralogs with STK11IP: view

Variants for STK11IP Gene

Sequence variations from dbSNP and Humsavar for STK11IP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000273638 -- 219,610,051(+) ACAAG(A/G)ATTGT intron-variant, utr-variant-3-prime
rs1000275226 -- 219,600,254(+) AGAGA(C/T)GAGGT intron-variant
rs1000311597 -- 219,613,264(+) GGAGA(G/T)GGGGT intron-variant
rs1000410457 -- 219,608,525(+) GGGGG(A/G)GGGCA intron-variant
rs1000448610 -- 219,612,335(+) CATCA(A/G)TGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK11IP Gene

Variant ID Type Subtype PubMed ID
nsv508887 CNV insertion 20534489

Variation tolerance for STK11IP Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.49; 64.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK11IP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK11IP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK11IP Gene

Disorders for STK11IP Gene

Relevant External Links for STK11IP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK11IP

No disorders were found for STK11IP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK11IP Gene

Publications for STK11IP Gene

  1. LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. (PMID: 11741830) Smith DP … Ashworth A (Human molecular genetics 2001) 2 3 4 22 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2. (PMID: 12438709) Buchet-Poyau K … Antonarakis SE (Cytogenetic and genome research 2002) 4 22 60
  4. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for STK11IP Gene

Sources for STK11IP Gene

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