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Aliases for STK11IP Gene

Aliases for STK11IP Gene

  • Serine/Threonine Kinase 11 Interacting Protein 2 3
  • LIP1 3 4 6
  • LKB1-Interacting Protein 1 3 4
  • STK11IP1 3 4
  • KIAA1898 4 6
  • LKB1IP 3 4
  • Serine/Threonine-Protein Kinase 11-Interacting Protein 3
  • STK11 Interacting Protein 3
  • LKB1 Interacting Protein 2

External Ids for STK11IP Gene

Previous GeneCards Identifiers for STK11IP Gene

  • GC02P218485
  • GC02P219183
  • GC02P220426
  • GC02P220665
  • GC02P220288
  • GC02P220170
  • GC02P220462
  • GC02P212315

Summaries for STK11IP Gene

GeneCards Summary for STK11IP Gene

STK11IP (Serine/Threonine Kinase 11 Interacting Protein) is a Protein Coding gene. Diseases associated with STK11IP include bannayan-riley-ruvalcaba syndrome and ruvalcaba syndrome. Among its related pathways are TGF-beta Receptor Signaling Pathway and LKB1 signaling events. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is NISCH.

UniProtKB/Swiss-Prot for STK11IP Gene

  • May regulate STK11/LKB1 function by controlling its subcellular localization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK11IP Gene

Genomics for STK11IP Gene

Regulatory Elements for STK11IP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STK11IP Gene

Start:
219,597,860 bp from pter
End:
219,616,451 bp from pter
Size:
18,592 bases
Orientation:
Plus strand

Genomic View for STK11IP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STK11IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK11IP Gene

Proteins for STK11IP Gene

  • Protein details for STK11IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1F8-S11IP_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 11-interacting protein
    Protein Accession:
    Q8N1F8
    Secondary Accessions:
    • Q8NAW9
    • Q8WXE4
    • Q96CN3
    • Q96PY9

    Protein attributes for STK11IP Gene

    Size:
    1099 amino acids
    Molecular mass:
    121401 Da
    Quaternary structure:
    • Found in a ternary complex composed of STK11/LKB1, STK11IP and SMAD4. Interacts with STK11/LKB1 and SMAD4.
    Miscellaneous:
    • This gene contains a polymorphic substitution resulting in a variant amino acid from Met-1 to Arg-1 compared to the official human genome. However, this variant sequence is in agreement with EST and mRNA sequences

    Alternative splice isoforms for STK11IP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK11IP Gene

Proteomics data for STK11IP Gene at MOPED

Post-translational modifications for STK11IP Gene

  • Ubiquitination at Lys114 and Lys294
  • Modification sites at PhosphoSitePlus

Other Protein References for STK11IP Gene

No data available for DME Specific Peptides for STK11IP Gene

Domains for STK11IP Gene

Protein Domains for STK11IP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STK11IP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N1F8

UniProtKB/Swiss-Prot:

S11IP_HUMAN :
  • Q8N1F8
Family:
  • Belongs to the STK11IP family.
Similarity:
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with STK11IP: view

No data available for Gene Families for STK11IP Gene

Function for STK11IP Gene

Molecular function for STK11IP Gene

UniProtKB/Swiss-Prot Function: May regulate STK11/LKB1 function by controlling its subcellular localization.

Gene Ontology (GO) - Molecular Function for STK11IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 11741830
genes like me logo Genes that share ontologies with STK11IP: view
genes like me logo Genes that share phenotypes with STK11IP: view

Animal Model Products

CRISPR Products

miRNA for STK11IP Gene

miRTarBase miRNAs that target STK11IP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STK11IP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for STK11IP Gene

Localization for STK11IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK11IP Gene

Cytoplasm. Note=Some cells show granular or punctuate expression. Colocalizes with STK11/LKB1 and SMAD4 in granular or punctuate structures.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK11IP Gene COMPARTMENTS Subcellular localization image for STK11IP gene
Compartment Confidence
mitochondrion 2
nucleus 2
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for STK11IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005765 lysosomal membrane IDA 17897319
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with STK11IP: view

Pathways for STK11IP Gene

genes like me logo Genes that share pathways with STK11IP: view

Pathways by source for STK11IP Gene

2 BioSystems pathways for STK11IP Gene

Gene Ontology (GO) - Biological Process for STK11IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008104 protein localization IDA 11741830
genes like me logo Genes that share ontologies with STK11IP: view

Transcripts for STK11IP Gene

Unigene Clusters for STK11IP Gene

Serine/threonine kinase 11 interacting protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STK11IP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK11IP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - - -
SP2: - - - -
SP3: -
SP4: - - -
SP5:
SP6:
SP7: - - -
SP8:
SP9:
SP10: - -

ExUns: 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for STK11IP Gene

GeneLoc Exon Structure for
STK11IP
ECgene alternative splicing isoforms for
STK11IP

Expression for STK11IP Gene

mRNA expression in normal human tissues for STK11IP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STK11IP Gene

SOURCE GeneReport for Unigene cluster for STK11IP Gene Hs.22410

genes like me logo Genes that share expressions with STK11IP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STK11IP Gene

Orthologs for STK11IP Gene

This gene was present in the common ancestor of animals.

Orthologs for STK11IP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK11IP 35
  • 99.02 (n)
  • 98.71 (a)
STK11IP 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STK11IP 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK11IP 35
  • 82.09 (n)
  • 78.6 (a)
STK11IP 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk11ip 35
  • 79.33 (n)
  • 75.63 (a)
Stk11ip 16
Stk11ip 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STK11IP 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk11ip 35
  • 79.73 (n)
  • 75.96 (a)
chicken
(Gallus gallus)
Aves STK11IP 35
  • 58.32 (n)
  • 52.54 (a)
STK11IP 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK11IP 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk11ip 35
  • 49.53 (n)
  • 41.77 (a)
zebrafish
(Danio rerio)
Actinopterygii stk11ip 35
  • 48.29 (n)
  • 42.23 (a)
stk11ip 36
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9044 36
  • 18 (a)
OneToOne
Species with no ortholog for STK11IP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STK11IP Gene

ENSEMBL:
Gene Tree for STK11IP (if available)
TreeFam:
Gene Tree for STK11IP (if available)

Paralogs for STK11IP Gene

Paralogs for STK11IP Gene

genes like me logo Genes that share paralogs with STK11IP: view

Variants for STK11IP Gene

Sequence variations from dbSNP and Humsavar for STK11IP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs581547 -- 219,611,923(+) TGCCA(C/T)GGGCA intron-variant
rs584006 -- 219,610,264(+) CTTAG(C/T)GACAC intron-variant
rs611780 -- 219,610,491(+) tctgc(C/T)ttccg intron-variant
rs611865 -- 219,610,552(+) cgccc(A/G)ccacc intron-variant
rs620698 -- 219,601,477(+) AAGGA(G/T)CCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STK11IP Gene

Variant ID Type Subtype PubMed ID
dgv4438n71 CNV Loss 21882294
nsv875876 CNV Loss 21882294
nsv508887 CNV Insertion 20534489

Relevant External Links for STK11IP Gene

HapMap Linkage Disequilibrium report
STK11IP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK11IP Gene

Disorders for STK11IP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for STK11IP Gene including...

Search for STK11IP Gene in MalaCards »

(2) University of Copenhagen DISEASES for STK11IP Gene

genes like me logo Genes that share disorders with STK11IP: view

No data available for UniProtKB/Swiss-Prot for STK11IP Gene

Publications for STK11IP Gene

  1. LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. (PMID: 11741830) Smith D.P. … Ashworth A. (Hum. Mol. Genet. 2001) 2 3 4 23
  2. Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2. (PMID: 12438709) Buchet-Poyau K. … Antonarakis S.E. (Cytogenet. Genome Res. 2002) 4 23
  3. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas. (PMID: 17521700) Conde E. … Sanchez-Cespedes M. (Hum. Pathol. 2007) 3

Products for STK11IP Gene

Sources for STK11IP Gene

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