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Aliases for STK11IP Gene

Aliases for STK11IP Gene

  • Serine/Threonine Kinase 11 Interacting Protein 2 3 5
  • LKB1-Interacting Protein 1 3 4
  • STK11IP1 3 4
  • LKB1IP 3 4
  • LIP1 3 4
  • STK11 Interacting Protein 3
  • LKB1 Interacting Protein 2
  • KIAA1898 4

External Ids for STK11IP Gene

Previous GeneCards Identifiers for STK11IP Gene

  • GC02P218485
  • GC02P219183
  • GC02P220426
  • GC02P220665
  • GC02P220288
  • GC02P220170
  • GC02P220462
  • GC02P212315

Summaries for STK11IP Gene

GeneCards Summary for STK11IP Gene

STK11IP (Serine/Threonine Kinase 11 Interacting Protein) is a Protein Coding gene. Among its related pathways are TGF-beta Receptor Signaling Pathway and LKB1 signaling events. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is NISCH.

UniProtKB/Swiss-Prot for STK11IP Gene

  • May regulate STK11/LKB1 function by controlling its subcellular localization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK11IP Gene

Genomics for STK11IP Gene

Regulatory Elements for STK11IP Gene

Enhancers for STK11IP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STK11IP on UCSC Golden Path with GeneCards custom track

Promoters for STK11IP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STK11IP on UCSC Golden Path with GeneCards custom track

Genomic Location for STK11IP Gene

219,597,860 bp from pter
219,616,451 bp from pter
18,592 bases
Plus strand

Genomic View for STK11IP Gene

Genes around STK11IP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK11IP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK11IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK11IP Gene

Proteins for STK11IP Gene

  • Protein details for STK11IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase 11-interacting protein
    Protein Accession:
    Secondary Accessions:
    • Q8NAW9
    • Q8WXE4
    • Q96CN3
    • Q96PY9

    Protein attributes for STK11IP Gene

    1099 amino acids
    Molecular mass:
    121401 Da
    Quaternary structure:
    • Found in a ternary complex composed of STK11/LKB1, STK11IP and SMAD4. Interacts with STK11/LKB1 and SMAD4.
    • This gene contains a polymorphic substitution resulting in a variant amino acid from Met-1 to Arg-1 compared to the official human genome. However, this variant sequence is in agreement with EST and mRNA sequences.

    Alternative splice isoforms for STK11IP Gene


neXtProt entry for STK11IP Gene

Proteomics data for STK11IP Gene at MOPED

Post-translational modifications for STK11IP Gene

  • Ubiquitination at Lys 114 and Lys 294
  • Modification sites at PhosphoSitePlus

Other Protein References for STK11IP Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for STK11IP

No data available for DME Specific Peptides for STK11IP Gene

Domains & Families for STK11IP Gene

Protein Domains for STK11IP Gene

Suggested Antigen Peptide Sequences for STK11IP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the STK11IP family.
  • Contains 8 LRR (leucine-rich) repeats.
  • Belongs to the STK11IP family.
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with STK11IP: view

No data available for Gene Families for STK11IP Gene

Function for STK11IP Gene

Molecular function for STK11IP Gene

UniProtKB/Swiss-Prot Function:
May regulate STK11/LKB1 function by controlling its subcellular localization.
genes like me logo Genes that share phenotypes with STK11IP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STK11IP

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STK11IP Gene

Localization for STK11IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK11IP Gene

Cytoplasm. Note=Some cells show granular or punctuate expression. Colocalizes with STK11/LKB1 and SMAD4 in granular or punctuate structures.

Subcellular locations from

Jensen Localization Image for STK11IP Gene COMPARTMENTS Subcellular localization image for STK11IP gene
Compartment Confidence
lysosome 5
vacuole 5
cytosol 3
mitochondrion 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for STK11IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11741830
genes like me logo Genes that share ontologies with STK11IP: view

Pathways & Interactions for STK11IP Gene

genes like me logo Genes that share pathways with STK11IP: view

Pathways by source for STK11IP Gene

2 BioSystems pathways for STK11IP Gene

Gene Ontology (GO) - Biological Process for STK11IP Gene


No data available for SIGNOR curated interactions for STK11IP Gene

Drugs & Compounds for STK11IP Gene

No Compound Related Data Available

Transcripts for STK11IP Gene

Unigene Clusters for STK11IP Gene

Serine/threonine kinase 11 interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STK11IP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - - -
SP2: - - - -
SP3: -
SP4: - - -
SP7: - - -
SP10: - -

ExUns: 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28
SP1: - - -
SP6: -

Relevant External Links for STK11IP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STK11IP Gene

mRNA expression in normal human tissues for STK11IP Gene

Protein differential expression in normal tissues from HIPED for STK11IP Gene

This gene is overexpressed in Breast (31.8), Pancreas (8.5), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STK11IP Gene

SOURCE GeneReport for Unigene cluster for STK11IP Gene Hs.22410

genes like me logo Genes that share expression patterns with STK11IP: view

Protein tissue co-expression partners for STK11IP Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STK11IP Gene

Orthologs for STK11IP Gene

This gene was present in the common ancestor of animals.

Orthologs for STK11IP Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia STK11IP 35
  • 82.09 (n)
  • 78.6 (a)
STK11IP 36
  • 78 (a)
(Mus musculus)
Mammalia Stk11ip 35
  • 79.33 (n)
  • 75.63 (a)
Stk11ip 16
Stk11ip 36
  • 74 (a)
(Pan troglodytes)
Mammalia STK11IP 35
  • 99.02 (n)
  • 98.71 (a)
STK11IP 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Stk11ip 35
  • 79.73 (n)
  • 75.96 (a)
(Bos Taurus)
Mammalia STK11IP 36
  • 78 (a)
(Monodelphis domestica)
Mammalia STK11IP 36
  • 61 (a)
(Gallus gallus)
Aves STK11IP 35
  • 58.32 (n)
  • 52.54 (a)
STK11IP 36
  • 38 (a)
(Anolis carolinensis)
Reptilia STK11IP 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stk11ip 35
  • 49.53 (n)
  • 41.77 (a)
(Danio rerio)
Actinopterygii stk11ip 35
  • 48.29 (n)
  • 42.23 (a)
stk11ip 36
  • 34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9044 36
  • 18 (a)
Species with no ortholog for STK11IP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STK11IP Gene

Gene Tree for STK11IP (if available)
Gene Tree for STK11IP (if available)

Paralogs for STK11IP Gene

Paralogs for STK11IP Gene

genes like me logo Genes that share paralogs with STK11IP: view

Variants for STK11IP Gene

Sequence variations from dbSNP and Humsavar for STK11IP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs17855575 - 219,607,063(+) AGTCC(A/C/G)TGTGA nc-transcript-variant, reference, missense
rs17855576 - 219,607,113(+) AGCCC(C/G/T)GAACT nc-transcript-variant, reference, missense, stop-gained
rs673951 - 219,608,633(-) CCGTA(C/T)GCCCT nc-transcript-variant, reference, missense
rs627530 - 219,611,721(+) TCCGT(C/T)TGCCA nc-transcript-variant, downstream-variant-500B, reference, missense
rs17853279 - 219,616,146(+) TTTCC(A/G)TCGGA nc-transcript-variant, downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for STK11IP Gene

Variant ID Type Subtype PubMed ID
dgv4438n71 CNV Loss 21882294
nsv875876 CNV Loss 21882294
nsv508887 CNV Insertion 20534489

Variation tolerance for STK11IP Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.49; 64.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STK11IP Gene

Disorders for STK11IP Gene

Relevant External Links for STK11IP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STK11IP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STK11IP Gene

Publications for STK11IP Gene

  1. LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. (PMID: 11741830) Smith D.P. … Ashworth A. (Hum. Mol. Genet. 2001) 2 3 4 23 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A systems-wide screen identifies substrates of the SCFI^TrCP ubiquitin ligase. (PMID: 25515538) Low T.Y. … Heck A.J. (Sci Signal 2014) 3

Products for STK11IP Gene

Sources for STK11IP Gene