Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



STK11IP Gene

protein-coding   GIFtS: 53
GCID: GC02P220462

Serine/Threonine Kinase 11 Interacting Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Serine/Threonine Kinase 11 Interacting Protein1 2     LKB1-Interacting Protein 12 3
LIP12 3 5     KIAA18983 5
LKB1 Interacting Protein1 2     Serine/Threonine Kinase 11-Interacting Protein2
LKB1IP2 3     Serine/Threonine-Protein Kinase 11-Interacting Protein2
STK11IP12 3     STK11 Interacting Protein2

External Ids:    HGNC: 191841   Entrez Gene: 1147902   Ensembl: ENSG000001445897   OMIM: 6071725   UniProtKB: Q8N1F83   

Export aliases for STK11IP gene to outside databases

Previous GC identifers: GC02P218485 GC02P219183 GC02P220426 GC02P220665 GC02P220288 GC02P220170 GC02P212315


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for STK11IP Gene:
STK11IP (serine/threonine kinase 11 interacting protein) is a protein-coding gene. Diseases associated with STK11IP include bannayan-riley-ruvalcaba syndrome, and ruvalcaba syndrome. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is NISCH.

UniProtKB/Swiss-Prot: S11IP_HUMAN, Q8N1F8
Function: May regulate STK11/LKB1 function by controlling its subcellular localization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STK11IP gene promoter:
         AhR   SRF   ATF-2   SRF (504 AA)   STAT5A   NF-E2 p45   Max   ARP-1   c-Jun   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK11IP promoter sequence
   Search Chromatin IP Primers for STK11IP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK11IP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

STK11IP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK11IP gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P220462:  view genomic region     (about GC identifiers)

Start:
220,462,582 bp from pter      End:
220,481,173 bp from pter
Size:
18,592 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: S11IP_HUMAN, Q8N1F8 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 11-interacting protein  
Size: 1099 amino acids; 121401 Da
Subunit: Found in a ternary complex composed of STK11/LKB1, STK11IP and SMAD4. Interacts with STK11/LKB1 and SMAD4
Miscellaneous: This gene contains a polymorphic substitution resulting in a variant amino acid from Met-1 to Arg-1
compared to the official human genome. However, this variant sequence is in agreement with EST and mRNA sequences
Caution: It is uncertain whether Met-1 or Met-12 is the initiator
Secondary accessions: Q8NAW9 Q8WXE4 Q96CN3 Q96PY9
Alternative splicing: 2 isoforms:  Q8N1F8-1   Q8N1F8-2   

Explore the universe of human proteins at neXtProt for STK11IP: NX_Q8N1F8

Explore proteomics data for STK11IP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys114, Lys294
  • Modification sites at PhosphoSitePlus

  • See STK11IP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443134.2  
    ENSEMBL proteins: 
     ENSP00000389383   ENSP00000394192   ENSP00000469777   ENSP00000403923   ENSP00000406371  
     ENSP00000295641  

    STK11IP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for STK11IP
    OriGene Custom MassSpec
    OriGene Custom Protein Services for STK11IP
    GenScript Custom Purified and Recombinant Proteins Services for STK11IP
    Novus Biologicals STK11IP Protein
    Novus Biologicals STK11IP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STK11IP

    STK11IP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for STK11IP
    OriGene Custom Antibody Services for STK11IP
    Novus Biologicals STK11IP Antibodies
    Search for Antibodies for STK11IP at Abcam
    Cloud-Clone Corp. Antibodies for STK11IP
    ThermoFisher Antibodies for STK11IP
    LSBio Antibodies in human, mouse, rat for STK11IP

    STK11IP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STK11IP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STK11IP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STK11IP
    Cloud-Clone Corp. CLIAs for STK11IP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR001611 Leu-rich_rpt

    Graphical View of Domain Structure for InterPro Entry Q8N1F8

    ProtoNet protein and cluster: Q8N1F8

    1 Blocks protein domain: IPB001611 Leucine-rich repeat signature

    UniProtKB/Swiss-Prot: S11IP_HUMAN, Q8N1F8
    Similarity: Belongs to the STK11IP family
    Similarity: Contains 8 LRR (leucine-rich) repeats


    STK11IP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S11IP_HUMAN, Q8N1F8
    Function: May regulate STK11/LKB1 function by controlling its subcellular localization

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019901protein kinase binding IPI11741830
         
    STK11IP for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for STK11IP:
     Decreased G3BP1 protein expres  Decreased viability 

         1 MGI phenotypic allele for Stk11ip (no phenotypes)

    STK11IP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Stk11iptm1Lex for STK11IP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STK11IP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STK11IP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STK11IP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STK11IP

    miRNA
    Products:
        
    miRTarBase miRNAs that target STK11IP:
    hsa-mir-23b-3p (MIRT046306)

    Block miRNA regulation of human, mouse, rat STK11IP using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate STK11IP:
    hsa-miR-4324 hsa-miR-4251 hsa-miR-539
    SwitchGear 3'UTR luciferase reporter plasmidSTK11IP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STK11IP
    Predesigned siRNA for gene silencing in human, mouse, rat STK11IP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STK11IP

    Clone
    Products:
         
    OriGene clones in human, mouse for STK11IP (see all 7)
    OriGene ORF clones in mouse, rat for STK11IP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STK11IP (NM_052902)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STK11IP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK11IP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STK11IP
    Browse ESI BIO Cell Lines and PureStem Progenitors for STK11IP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK11IP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    S11IP_HUMAN, Q8N1F8: Cytoplasm. Note=Some cells show granular or punctuate expression. Colocalizes with
    STK11/LKB1 and SMAD4 in granular or punctuate structures
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    nucleus2
    plasma membrane2
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005765lysosomal membrane IDA17897319
    GO:0043231intracellular membrane-bounded organelle IDA--

    STK11IP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for STK11IP About    
    See pathways by source

    SuperPathContained pathways About
    1TGF-beta Receptor Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    2LKB1 signaling events
    LKB1 signaling events


    2 BioSystems Pathways for STK11IP
        TGF-beta Receptor Signaling Pathway
    LKB1 signaling events


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STK11IP
    Interactions:

        GeneGlobe Interaction Network for STK11IP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for STK11IP (Q8N1F83 ENSP000002956414) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK11Q158313, ENSP000003248564I2D: score=3 STRING: ENSP00000324856
    TLR9Q9NR963, ENSP000003538744I2D: score=1 STRING: ENSP00000353874
    SMAD4Q134853, ENSP000003415514I2D: score=2 STRING: ENSP00000341551
    TLR4O002063, ENSP000003630894I2D: score=1 STRING: ENSP00000363089
    NCAM2O153943, ENSP000003833924I2D: score=1 STRING: ENSP00000383392
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008104protein localization IDA11741830

    STK11IP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STK11IP (S11IP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for STK11IP gene: 
    NM_052902.2  

    Unigene Cluster for STK11IP:

    Serine/threonine kinase 11 interacting protein
    Hs.22410  [show with all ESTs]
    Unigene Representative Sequence: BC034051
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456909 ENST00000475843(uc010zlj.2) ENST00000456857 ENST00000475396(uc002vmm.1)
    ENST00000468584 ENST00000459692 ENST00000465230 ENST00000466648 ENST00000473899
    ENST00000483319 ENST00000413891 ENST00000495941 ENST00000447191 ENST00000494777
    ENST00000295641(uc010zlk.2 uc010zll.2 uc002vml.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STK11IP using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate STK11IP:
    hsa-miR-4324 hsa-miR-4251 hsa-miR-539
    SwitchGear 3'UTR luciferase reporter plasmidSTK11IP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STK11IP
    Predesigned siRNA for gene silencing in human, mouse, rat STK11IP
    Clone
    Products:
         
    OriGene clones in human, mouse for STK11IP (see all 7)
    OriGene ORF clones in mouse, rat for STK11IP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STK11IP (NM_052902)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STK11IP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK11IP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STK11IP
    OriGene qSTAR qPCR primer pairs in human, mouse for STK11IP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STK11IP
      QuantiTect SYBR Green Assays in human, mouse, rat STK11IP
      QuantiFast Probe-based Assays in human, mouse, rat STK11IP

    Additional mRNA sequence: 

    AB067485.1 AF450267.1 AK091963.1 AK295609.1 AK296632.1 AK299894.1 AK300611.1 BC014114.2 
    BC034051.1 

    9 DOTS entries:

    DT.446259  DT.100029951  DT.40212376  DT.95168946  DT.100029950  DT.100679408  DT.121010155  DT.95199680 
    DT.97828270 

    Selected AceView cDNA sequences (see all 146):

    AX747280 CN480824 AL043115 AI307255 AA917033 BM980281 AI655121 AI375606 
    BF115961 AI084997 BM561493 AB067485 BQ651062 AI335770 CR597490 BP377304 
    BQ643756 BU186991 AI250263 BU624830 BQ646374 BX506144 AI798941 BM988830 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STK11IP (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
    SP1:              -     -           -           -                       -     -                             -                                                   
    SP2:                                -           -                       -     -                                                                                 
    SP3:                                                                                                        -                                                   
    SP4:                    -           -           -                                                                                                               
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28
    SP1:                    -                             -           -         
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for STK11IP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    STK11IP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGAGCTG
    STK11IP Expression
    About this image

    STK11IP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STK11IP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.22410
        Custom PCR Arrays for STK11IP
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for STK11IP
    OriGene qSTAR qPCR primer pairs in human, mouse for STK11IP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STK11IP
    QuantiTect SYBR Green Assays in human, mouse, rat STK11IP
    QuantiFast Probe-based Assays in human, mouse, rat STK11IP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK11IP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for STK11IP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk11ip1 , 5 serine/threonine kinase 11 interacting protein1, 5 79.33(n)1
    75.63(a)1
      1 (39.16 cM)5
    717281  NM_027886.31  NP_082162.31 
     755215295 
    chicken
    (Gallus gallus)
    Aves STK11IP1 serine/threonine kinase 11 interacting protein 58.32(n)
    52.54(a)
      424195  NM_001012918.1  NP_001012936.1 
    lizard
    (Anolis carolinensis)
    Reptilia STK11IP6
    serine/threonine kinase 11 interacting protein
    40(a)
    1 ↔ 1
    1(94417441-94455419)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia stk11ip1 serine/threonine kinase 11 interacting protein 49.53(n)
    41.77(a)
      394784  NM_203846.1  NP_989177.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stk11ip1 serine/threonine kinase 11 interacting protein 48.29(n)
    42.23(a)
      795019  NM_200288.2  NP_956582.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90446
    --
    18(a)
    1 ↔ 1
    2L(5949450-5955235)


    ENSEMBL Gene Tree for STK11IP (if available)
    TreeFam Gene Tree for STK11IP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for STK11IP gene
    NISCH2  

    STK11IP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for STK11IP (see all 569)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817148261,2
    --220460600(+) GTAGGC/GGCTGA 1 -- us2k10--------
    rs1401648311,2
    --220460664(+) ATAGGC/TTAAGA 1 -- us2k10--------
    rs1467824221,2
    --220461041(+) TGATCG/TCGGCT 1 -- us2k10--------
    rs1391980691,2
    --220461134(+) ATGCCC/TGGCTA 1 -- us2k10--------
    rs1433642161,2
    C--220461135(+) TGCCCA/GGCTAA 1 -- us2k10--------
    rs2010447571,2
    C--220461163(+) ACACA-/GGGTTT 1 -- us2k10--------
    rs1475339921,2
    --220461256(+) GCGTGA/TGCCAC 1 -- us2k10--------
    rs74242441,2
    C--220461372(+) gaagaG/Tgaatt 1 -- us2k1 trp30--------
    rs1381708831,2
    --220461420(+) TGGGAA/GACAGG 1 -- us2k10--------
    rs761872601,2
    C,F--220461479(+) TTTAGT/CTCAAA 1 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for STK11IP (220462582 - 220481173 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for STK11IP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508887CNV Insertion20534489
    dgv4438n71CNV Loss21882294
    nsv875876CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STK11IP
    DNA2.0 Custom Variant and Variant Library Synthesis for STK11IP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607172    OMIM disorders: --

    4 diseases for STK11IP:    
    About MalaCards
    bannayan-riley-ruvalcaba syndrome    ruvalcaba syndrome    peutz-jeghers syndrome    cowden disease

    2 diseases from the University of Copenhagen DISEASES database for STK11IP:
    Peutz-Jeghers syndrome     Bannayan-Riley-Ruvalcaba syndrome

    STK11IP for disorders           About GeneDecksing


    Export disorders for STK11IP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for STK11IP gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with STK11IP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. (PubMed id 11741830)1, 2, 3, 9 Smith D.P....Ashworth A. (Hum. Mol. Genet. 2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    4. Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2. (PubMed id 12438709)2, 9 Buchet-Poyau K.... Antonarakis S.E. (Cytogenet. Genome Res. 2002)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Negative regulation of TGFI^ signaling by the kinase LKB1 and the scaffolding protein LIP1. (PubMed id 20974850)1 MorAcn A....Moustakas A. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 114790 HGNC: 19184 AceView: STK11IP Ensembl:ENSG00000144589 euGenes: HUgn114790
    ECgene: STK11IP H-InvDB: STK11IP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1898

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for STK11IP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for STK11IP gene:
    Search GeneIP for patents involving STK11IP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for STK11IP   OriGene RNAi products in human, mouse, rat for STK11IP  
     OriGene qPCR primer pairs and template standards for STK11IP   OriGene Protein Over-expression Lysate for STK11IP  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for STK11IP  
     OriGene qSTAR qPCR primer pairs in human, mouse for STK11IP   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for STK11IP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for STK11IP   OriGene Custom Protein Services for STK11IP  

     
     
     Block miRNA regulation of human, mouse, rat STK11IP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing STK11IP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK11IP Predesigned siRNA for gene silencing in human, mouse, rat STK11IP
     QuantiFast Probe-based Assays in human, mouse, rat STK11IP QuantiTect SYBR Green Assays in human, mouse, rat STK11IP
     Custom PCR Arrays for STK11IP Search Chromatin IP Primers for STK11IP
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STK11IP  GeneGlobe Interaction Network for STK11IP
     Regulatory tfbs in STK11IP promoter
     GenScript Custom Purified and Recombinant Proteins Services for STK11IP GenScript cDNA clones with any tag delivered in your preferred vector for STK11IP
     GenScript Custom Assay Services for STK11IP GenScript Custom overexpressing Cell Line Services for STK11IP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for STK11IP (S11IP)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     STK11IP antibodies
     STK11IP proteins
     STK11IP lysates
     Search for Antibodies for STK11IP at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for STK11IP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for STK11IP
     Antibodies for STK11IP
     ELISAs for STK11IP
     CLIAs for STK11IP



     Browse ESI BIO Cell Lines and PureStem Progenitors for STK11IP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK11IP
     SwitchGear 3'UTR luciferase reporter plasmids for STK11IP
     SwitchGear Promoter luciferase reporter plasmids for STK11IP
     ThermoFisher Antibodies for STK11IP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK11IP
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STK11IP
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STK11IP
     LSBio Antibodies in human, mouse, rat for STK11IP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      STK11IP gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4